Paul Spencer Brookes, Ph.D.

See information for Patients. Viewing information for Researchers.

Current Appointments

• Associate Professor - Department of Anesthesiology (SMD)
• Associate Professor - Department of Pharmacology and Physiology (SMD)

Education
PhD Biochemistry	UK-Cambridge U Med Sch	1997
BS Biochemistry	UK - Non-Medical School	1993

Fellowship Awards
Post-Doctoral Fellowship Award ($60,000) AHA Southeast Affiliate 100% Effort "Mitochondria and NO• in cardiac hypertrophy"	1999 - 2001
DEPARTMENT OF PATHOLOGY, UNIVERSITY OF ALABAMA AT BIRMINGHAM, USA Post-doctoral Fellow (with Prof. VM Darley-Usmar & Dr. PG Anderson)	1998 - 2001
INSTITUTE OF NEUROLOGY, UNIVERSITY COLLEGE LONDON, UK Post-doctoral Fellow (with Prof. JB Clark & Dr. SJR Heales)	1997 - 1998
Postdoctoral Fellowship, American Heart Association, Southeast Affiliate	1999

Recent Journal Articles
Showing the 5 most recent journal articles. (38 available)
Tompkins AJ; Burwell LS; Digerness SB; Zaragoza C; Holman WL; Brookes PS. "Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition." Biochimica et biophysica acta. 2006; 1762(2):223-31. Epub 2005 Oct 21.
Burwell LS; Nadtochiy SM; Tompkins AJ; Young S; Brookes PS. "Direct evidence for S-nitrosation of mitochondrial complex I." The Biochemical journal. 2006; 394(Pt 3):627-34.
Nadtochiy SM; Tompkins AJ; Brookes PS. "Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection." The Biochemical journal. 2006; 395(3):611-8.
Brookes PS; Freeman RS; Barone MC. "A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"." Free radical biology & medicine. 2006; 41(1):41-5. Epub 2006 Apr 01.
Brookes PS. "Mitochondrial H(+) leak and ROS generation: an odd couple." Free radical biology & medicine. 2005; 38(1):12-23.