Steve N. Georas, M.D.

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Dr. Georas is Professor of Medicine and Environmental Medicine at the University of Rochester Medical Center, and Director of the Division of Pulmonary and Critical Care Medicine. From 1994-2006, Dr. Georas was a faculty member at Johns Hopkins University in the Pulmonary Division with a joint appointment in the Division of Allergy & Clinical Immunology, and Department of Environmental Health Sciences. He moved to the University of Rochester in 2006. Dr. Georas directs a research group investigating mechanisms of dendritic cell and T cell activation in allergic diseases. Current studies are aimed at defining molecular pathways by which allergens and particulate matter activate dendritic cells and influences allergen-specific immunity, with an emphasis on the role of oxidative stress and Nrf2-mediated signaling pathways in allergic innate immunity. A separate line of research is investigating how lysophosphatidic acid is generated in the allergic lung, and exploring the role of different LPA receptors in lung inflammation and immune responses. These studies should further our understanding of how inhaled pollutants and allergens affect respiratory immune responses with a long-term goal of alleviating the burden of asthma in vulnerable and susceptible human subjects.

Current Appointments

• Professor - Department of Medicine (SMD)
• Professor - Department of Environmental Medicine (SMD)

Education
M.D. Medicine	Brown Univ Bio/Med Sciences	1987
B.S. Applied Math / Biology	Brown University	1983

Lab Description

Our lab consists of a collaborative group of technicians, students and post-doctoral fellows studying cell activation in asthma and lung inflammation. Interested candidates are encouraged to apply.

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Lab Website

http://www2.envmed.rochester.edu/envmed/tox/faculty/georas.html

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Recent Journal Articles
Showing the 5 most recent journal articles. (54 available)
Guo J; Lu W; Shimoda LA; Semenza GL; Georas SN. "Enhanced Interferon-gamma Gene Expression in T Cells and Reduced Ovalbumin-Dependent Lung Eosinophilia in Hypoxia-Inducible Factor-1-alpha-Deficient Mice." International archives of allergy and immunology. 2009; 149(2):98-102. Epub 2009 Jan 06.
Georas SN. "Lysophosphatidic acid and autotaxin: emerging roles in innate and adaptive immunity." Immunologic research. 2009; Epub 2009 Jan 30.
Roman J; Rangasamy T; Guo J; Sugunan S; Meednu N; Packirisamy G; Shimoda L; Golding A; Semenza G; Georas SN. "T Cell Activation Under Hypoxic Conditions Enhances Interferon-gamma Secretion." American journal of respiratory cell and molecular biology. 2009; Epub 2009 Apr 16.
Georas, SN; Beck, L. "Dangerous allergens: innate immunity, dendritic cells and allergic asthma". Expert Review of Clinical Immunology 4 (2008): 777-785.
Hansel NN; Cheadle C; Diette GB; Wright J; Thompson KM; Barnes KC; Georas SN. "Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms." Allergy. 2008; 63(3):366-9.