Kate Guernsey Ackerman, M.D.

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Contact

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester, New York 14642

Office: 585 276-4001 (primary)

Lab: 585 276-4238 (primary)

Fax: 585 276-0232 (primary)

Portrait

Congenital Diaphragmatic Hernia (CDH) is a relatively common birth defect that results in a high rate of neonatal illness or death. The focus of Dr. Ackerman's laboratory is to identify genes that are necessary for development of the diaphragm and the lung.

Current research projects include:

- To identify mechnisms and pathway genes in Fog2 mediated diaphragm development and Fog2 mediated pulmonary lobar braching

-To investigate mechanisms of development in Barx1 homeobox gene associated posterior medical diaphragmatic hernia.

_To develop models for conditional deletion of genes on mesenchymal tissue of the diaphragm

-To develop new models of abnormal diaphragm and lung development from forward genetic screening

-To characterize human diaphragmatic defects and translate findings in animal models to the human disease with the hopes of modulating outcome in fetuses and neonates with congenital diaphragmatic defects

Specialty

Pediatric Critical Care

Current Appointments

Education
MD Medicine State University of New York at Buffalo, School of Medicine & Biomedical Sciences 1995
BS Biology Cornell University 1991
Post-Doctoral Training & Residency
Research Fellow, Brigham and Women's Hospital, Division of Genetics 2001 - 2002
Clinical Fellow in Pediatric Critical Care (Anesthesia), Children's Hospital 1998 - 2001
Resident in Pediatrics, Pediatrics, The Children's Hospital, Denver, CO 1996 - 1998
Intern in Pediatrics, Pediatrics, The Children's Hospital, Denver, CO 1995 - 1996
Fellowship Awards
Children's Hospital, Boston – Division of Emergency Medicine (Training Grant in Emergency Medicine) 2002 - 2004
Brigham and Women's Hospital – Division of Pulmonary and Critical Care and Children's Hospital, Boston - Pulmonary Division (Training Grant in Pulmonary Medicine) 2001 - 2002
Board Certifications
American Board of Pediatrics: Critical Care Medicine 2004 - Present
American Board of Pediatrics 1998 - Present

Lab Website

http://www.urmc.rochester.edu/pediatrics/research/biomedical-research/Ackerman-Lab/index.cfm

Recent Journal Articles
Showing the 5 most recent journal articles. (13 available)
Stevens, T.; van Wijngaarden, E.; Ackerman, K.G.; Lally, P.; Lally, K. "Timing of delivery and survival in infants with a prenatal diagnosis of congenital diaphragmatic hernia." Pediatrics 123 (2009).
Liu, X.; Ramjiganesh, T.; Chen, Y.H.; Chung, S.W.; Hall, S.R.; Schissel, S.L.; Padera, R.F. Jr.; Liao, R.; Ackerman, K.G.; Kajstura, J.; Leri, A.; Anversa, P.; Yet, S.F.; Layne, M.D.; Perrella M.A. "Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice." Circulation (2008).
Ackerman KG; Wang J; Luo L; Fujiwara Y; Orkin SH; Beier DR. "Gata4 is necessary for normal pulmonary lobar development." American journal of respiratory cell and molecular biology. 2007; 36(4):391-7. Epub 2006 Dec 01.
Pober, B.R.; Lin, A.; Russell, M.; Ackerman, K.G.; Chakravorty, S.; Strauss, B.; Westgate, M. N.; Wilson, J.; Donahoe, P.K.; Holmes, L.B. "Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program." Am.J.Med.Genet.A. 138 (2005): 81-88.
Ackerman KG; Huang H; Grasemann H; Puma C; Singer JB; Hill AE; Lander E; Nadeau JH; Churchill GA; Drazen JM; Beier DR. "Interacting genetic loci cause airway hyperresponsiveness." Physiological genomics. 2005; 21(1):105-11. Epub 2005 Jan 18.