Charles J. Lowenstein, M.D.
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Contact
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box ACVRI - 211 Bailey Road
Rochester, New York 14642
Office: 585 276-5077 (primary)
Lab: 585 276-9870
Fax: 585 276-9830
Dr. Lowenstein's research is focused on vascular biology. One team or researchers explores mechanisms of exocytosis, through which endothelial cells release pro-inflammatory and pro-thrombotic mediators. A second group of scientists study how platelets communicate with endothelial cells. A third area of research involves an exploration of the role of microRNA in endothelial cells. A fourth team investigates how nitric oxide affects vascular inflammation.
Current Appointments
- Chief - Department of Medicine (SMD)
- Director - Aab Cardiovascular Research Institute (SMD)
- Paul N. Yu Professorship in Cardiology - Department of Medicine (SMD)
- Professor - Department of Medicine (SMD)
| Education | ||
|---|---|---|
| BA Biochemistry | Harvard University | 1982 |
| MD Medicine | Harvard Medical School | 1986 |
| Medical Resident | Massachusetts General Hospital | Attended: 1986 - 1989 |
| Research and Clinical Fellow | Massachusetts General Hospital | Attended: 1989 - 1990 |
| Research Fellow | Massachusetts Institute of Technology | Attended: 1989 - 1990 |
| Cardiology Fellow | The Johns Hopkins University School of Medicine | Attended: 1991 - 1994 |
Lab Website
| Recent Journal Articles |
|---|
| Showing the 5 most recent journal articles. (110 available) |
| Yamakuchi M; Lowenstein CJ. "MiR-34, SIRT1 and p53: The feedback loop." Cell cycle (Georgetown, Tex.). 2009; 8(5):. Epub 2009 Mar 02. |
| Jeong Y; Chaupin DF; Matsushita K; Yamakuchi M; Cameron SJ; Morrell CN; Lowenstein CJ. "Aldosterone activates endothelial exocytosis." Proceedings of the National Academy of Sciences of the United States of America. 2009; Epub 2009 Feb 17. |
| Kanno Y; Into T; Lowenstein CJ; Matsushita K. "Nitric oxide regulates vascular calcification by interfering with TGF- signalling." Cardiovascular research. 2008; 77(1):221-30. Epub 2007 Oct 25. |
| Harris TA; Yamakuchi M; Ferlito M; Mendell JT; Lowenstein CJ. "MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1." Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(5):1516-21. Epub 2008 Jan 28. |
| Morrell CN; Sun H; Ikeda M; Beique JC; Swaim AM; Mason E; Martin TV; Thompson LE; Gozen O; Ampagoomian D; Sprengel R; Rothstein J; Faraday N; Huganir R; Lowenstein CJ. "Glutamate mediates platelet activation through the AMPA receptor." The Journal of experimental medicine. 2008; 205(3):575-84. Epub 2008 Feb 18. |
