Peer-Reviewed Journals


Gu, W., Wu. H., Miao, H., and Xue, H. (2014), Parameter Estimation for a Type of Nonlinear Stochastic Models Observed with Error, Computational Statistics and Data Analysis, 79, 113-119. PaperMatlab code & Data

Miao, H., Sangster, M.Y., Livingstone, A.M., Hilchey, S., Zhang, L., Topham, D.J., Mosmann, T.R., Holden-Wiltse, J., Perelson, A.S., Wu, H.*, Zand, M.S.* (2014), Modeling the Dynamics and Migratory Pathways of Virus-Specific Antibody-Secreting Cell Populations in Primary Influenza Infection, PLoS ONE, 9(8):e104781. PMID:25171166C code & Data

Miao, H., Wu, H., and Xue, H. (2014), Generalized Ordinary Differential Equation Models, Journal of the American Statistical Association, 2014 Oct;109(508):1672-1682. PMID:25544787 C code & Data

Wu, S., Liu, Z.P., Qiu, X., and Wu, H.* (2014), Modeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations, PLOS ONE, 2014 May 6;9(5):e95276. PMID:24802016R CodeData

Wu, H.*, Lu, T., Xue, H., and Liang, H. (2014), Sparse Additive ODEs for Dynamic Gene Regulatory Network Modeling, Journal of the American Statistical Association, 2014 Apr 2;109(506):700-716. PMID:2378633DataR Code GUI Tool

Wu, S., Xue, H., Wu, Y., Wu, H. (2014), Variable Selection for Sparse High-Dimensional Nonlinear Regression Models by Combining Nonnegative Garrote and Sure Independence Screening, Statistica Sinica, 2014 Jul;24(3):1365-1387. PMID:25170239DataMatlab Code

Ding, A.A. and Wu, H.* (2014), Estimation of ODE Parameters Using Constrained Local Polynomial Regression, Statistica Sinica, 24, 1613-1631.PaperR codeData

Linel, P., Wu, S., Deng, N., Wu, H.* (2014), Dynamic transcriptional signatures and network responses for clinical symptoms in influenza-infected human subjects using systems biology approaches, Journal of Pharmacokinetics and Pharmacodynamics, 41, 509-521, PMID:25015847.

Amneris E. Luque, Mark Orlando, U-Cheng Leong, Paul D. Allen, Joseph J. Guido, Hongmei Yang and Hulin Wu (2014), Hearing Function in Patients Living with HIV/AIDS, Ear and Hearing, 2014 Nov-Dec;35(6):e282-90. PMID:25127320

Liu, Z., Wu, H., Zhu, J., Miao, H. (2014), Systematic Identification of Transcriptional and Post-Transcriptional Regulatory Relationships during Influenza Virus Infection, BMC Bioinformatics, 15(1): 336. PMID:25281301R code & Data


Wang, J., Zhang, L., Jing, C., Ye, G., Wu, H., Miao, H., Wu, Y., Zhou X. (2013), Multi-scale agent-based modelling on melanoma and its related angiogenesis analysis, Theoretical Biology and Medical Modelling, 10:41

Yang, H., Topham, D., Holden-Wiltse, J., Wu, H. (2013), Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays , Journal of Biopharmaceutical Statistics,23, 921-926.PMID: 23786336R Code

Wu, S, and Wu, H.* (2013), More Powerful Significant Testing for Time Course Gene Expression Data Using Functional Principal Component Analysis Approaches, BMC Bioinformatics, 14:6.PMID: 23323795R CodeDataGUI Tool

Lu, N., Silva, J., Gu, Y., Gerber, S., Wu, H., Gelbard. H., Dewhurst, S., Miao, H. (2013), Directional histogram ratio at random probes: A local thresholding criterion for capillary images, Pattern Recognition, 46(7), 1933-1948. PMID: 23525856Matlab Code

Qiu, X., Wu, H. and Hu, R.  (2013), The Impact of Quantile and Rank Normalization Procedures on the Testing Power of Gene Differential Expression Analysis, BMC Bioinformatics,14:124. PMID: 23578321

Luo, R., Piovoso, M.J., Wu, H., Buzon, M.J., Martinez-Picado, J., Zurakowski, R. (2013), Modeling HIV-1 2-LTR Dynamics Following Raltegravir Intensification,  Journal of the Royal Society Interface, 10:20130186. PMID: 23658114

Yanni Xiao, Hongyu Miao, Sanyi Tang, Hulin Wu* (2013), Modeling Antiretroviral Drug Responses for HIV-1 infected Patients Using Differential Equation Models, Advanced Drug Delivery Reviews, 65, 940-953. PMID: 23603208

Alicia D. Henn, Shuang Wu, Xing Qiu, Melissa Ruda, Michael Stover, Hongmei Yang, Zhiping Liu, Stephen Welle, Jeanne Holden-Wiltse, Hulin Wu*, Martin S. Zand* (2013),  High-Resolution Temporal Response Patterns to Influenza Vaccine Reveal a Distinct Human Plasma Cell Gene Signature, Nature Scientific Reports, 3:2327. PMID: 23900141Data

Jason M Weaver; Hongmei Yang; David Roumanes; Frances Eun-Hyung Lee; Hulin Wu; John J. Treanor; Tim R Mosmann (2013), Increase in IFNγ(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza, PLoS One, 8(3):e57275. PMID: 23526940


Wu, H.*, Xue, H., Kumar A. (2012), Numerical Discretization-Based Estimation Methods for Ordinary Differential Equation Models via Penalized Spline Smoothing with Applications in Biomedical Research., Biometrics, 68(2):344-52 .PMID:22376200 Technical Proof R Code Patient 1 Data Patient 2 Data

Cao, J., Huang, J.Z., Wu, H. (2012), Penalized Nonlinear Least Squares Estimation of Time-Varying Parameters in Ordinary Differential Equations, Journal of Computational and Graphical Statistics (JCGS), 21:1, 42-56.PMID: 23155351

Lee, Y. and Wu, H.* (2012), MARS Approach for Global Sensitivity Analysis of Differential Equation Models with Applications to Dynamics of Influenza Infection, Bulletin of Mathematical Biology, 74(1):73-90.PMID: 21656089

Miao, H., Jin, X., Perelson, A.S., Wu, H. (2012), Evaluation of Multitype Mathematical Models for CFSE-Labeling Experiment Data, Bulletin of Mathematical Biology, 74(2):300-26.PMID: 21681605Data C Code

Zhou, J., Liu, S.Y., Zhou, F., Wu, H. (2012), Statistical Diagnosis of HIV Model (in Chinese). Chin Sci Bull (Chin Ver). 2012, 57: 666–672, doi: 10.1360/972011-1978.Paper

Henn, A.D., Laski, M., Yang, H., Qiu, X., Miao, H., Barry, C.T., Welle, S., Wu, H., Zand, M.S. (2012), Functionally Distinct Subpopulations of CpG-Activated Memory B Cells, Nature Scientific Reports, 2012;2:345. PMID: 22468229Data

Li, X., Miao, H., Henn, A.D., Topham, D.J.,  Wu, H.,  Zand, M.S., and Mosmann, T.R. (2012), Ki-67 Expression Reveals Strong, Transient Influenza Specific CD4 T Cell Responses After Adult Vaccination, Vaccine, 30, 4581-4584. .PMID: 22554464

Tang, S., Xiao, Y., Wang, N., and Wu, H. (2012), Piecewise HIV virus dynamic model with CD4+ T cell count-guided therapy: I, Journal of Theoretical Biology, 308, 123-234. PMID: 22659043


Wang, J., Zhang, G.,  Bambara, R.,  Li, D., Liang, H.,  Wu, H.,  Smith, H.,  Lowe, N.,  Demeter, L., and Dykes, C. (2011), Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI)-resistant Virus is Stimulated by Efavirenz (EFV) During Early Stages of Infection, Journal of Virology, 85(20):10861-73.PMID:21835788

Wu, H., Kumar, A., Miao, H., Holden-Wiltse, J., Mosmann, T.R., Livingstone, A.M., Belz, G.T., Perelson, A.S., Zand, M., Topham, D.J. (2011), Modeling of Influenza-Specific CD8+ T Cells During the Primary Response Indicates that the Spleen Is a Major Source of Effectors, Journal of Immunology, 187, 4474-4482. PMID:21948988 Data1 Data2GUI Tool

Lu, T., Liang, H., Li, H., Wu, H. (2011), High Dimensional ODEs Coupled with Mixed-Effects Modeling Techniques for Dynamic Gene Regulatory Network Identification, Journal of the American Statistical Association, JASA, 106:496 1242-1258. PMID: 21681605Appendix R Code GUI Tool

Liu, D., Lu, T., Niu, X.F., and Wu, H.* (2011), Mixed-Effects State Space Models for Analysis of Longitudinal Dynamic Systems, Biometrics, 67, 476-485.PMID:20825393

Fang, Y., Wu, H., Zhu, L. (2011), A Two-Stage Estimation Method for Random Coefficient Differential Equation Models with Application to Longitudinal HIV Dynamic Data, Statistica Sinica, 21, 1145-1170.PMID:22171150

Miao, H., Xia, X., Perelson, A.S., Wu, H. (2011), On Identifiability of Nonlinear ODE Models and Applications in Viral Dynamics, SIAM Review, 53, 3-39.PMID:21785515

Huang, Y., Wu, H., Holden-Wiltse, J., Acosta, P. (2011), A Dynamic Bayesian Nonlinear Mixed-Effects Model of HIV Response Incorporating Medication Adherence, Drug Resistance and Covariates, The Annals of Applied Statistics, 5(1), 551-577,.PMID: 22171150

Lartey, M., Sagoe, K.W., Yang, H., Kenu, E., Xexemeku, F., Oliver-Commey, J., Bioma, V., Seshie, M., Sagoe, A., Mingle, J., Flanigan, T.P., Wu, H., Kwara, A. (2011), Viral Decay Rates Are Similar in HIV-Infected Patients with and without TB Coinfection Treated with Efavirenz-containing Antiretroviral Therapy, Clinical Infectious Diseases, 52(4), 547-550.PMID:21252140


Zhang, J.T., Wu, H. (2010), Modeling HIV Dynamics Using Unified Mixed-effects Models, American Journal of Mathematical and Management Sciences, 30 (1-2), 83-109.Paper

Liang, H., Wu, H.*, (2010), Correction on “Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models (JASA, 103, 1570-1583),” Journal of the American Statistical Association, 105, 1636.

Baer, J., Santiago, F., Yang, H., Wu, H., Holden-Wiltse, J., Treanor, J., Topham, D.J. (2010), B Cell Responses to H5 Influenza HA in Human Subjects Vaccinated with Drifted Variants,  Vaccine, 28, 907-915. PMID: 19932673

Liang, H., Miao, H., and Wu, H. (2010), Estimation of constant and time-varying dynamic parameters of HIV infection in a nonlinear differential equation model, Annals of Applied Statistics, 4, 460-483. PMID: 20556240 PMCID: PMC2885820 Patient 1 Data Patient 2 Data

Wood, R., Liang, H., Wu, H., Middelkoop, K., Oni, T., Rangaka, M.X., Wilkinson, R.J., Bekker, L.G., Lawn, S. D. (2010), Changing prevalence of Tuberculosis infection with increasing age in high-burden townships in South Africa, the International Journal of Tuberculosis and Lung Disease, 14, 406-412. PMID: 20202297

Ma, J., Dykes, C., Wu, T., Huang, Y., Demeter, L., Wu, H. (2010), vFitness: a web-based computing tool for improving estimation of in vitro HIV-1 fitness experiments, BMC Bioinformatics, 11:261. PMID: 20482791 PMCID: PMC2882933

Xue, H., Miao, H., Wu, H. (2010), Sieve Estimation of Constant and Time-Varying Coefficients in Nonlinear Ordinary Differential Equation Models by Considering Both Numerical Error and Measurement Error, Annals of Statistics, 38, 2351-87.PMID:21132064

Miao, H., Hollenbaugh, J.A., Zand, M., Holden-Wiltse, J., Mosmann, T.R., Perelson, A.S., Wu, H., Topham, D.J. (2010), Quantifying the Early Immune Response and Adaptive Immune Response Kinetics in Mice Infected with Influenza A Virus, Journal of Virology, 84, 6687-6698. PMID: 20410284 DataGUI Tool

Wang, J., Liang, H., Bacheler, L., Wu, H., Deriziotis, K., Demeter, L.M., Dykes, C. (2010), The Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz Stimulates Replication of Human Immunodeficiency Virus Type 1 Harboring Certain Non-nucleoside Resistance Mutations, Virology, 402, 228-237. PMID: 20399480

Dykes, C., Wu, H., Sims, M., Holden-Wiltse, J., Demeter, L. (2010), Human immunodeficiency virus type 1 protease inhibitor drug-resistant mutants give discordant results when compared in single-cycle and multiple-cycle fitness assays,  Journal of Clinical Microbiology, 48, 4035-4043. PMID: 20826651

Huang, Y., Wu, H., Acosta, P. (2010), Hierarchical Bayesian Inference for HIV Dynamic Differential Equation Models Incorporating Multiple Treatment Factors, Biometrical Journal, 52(4), 470-486.PMID: 20661953


Miao, H., Dykes, C., Demeter, L., Wu, H. (2009), Differential Equation Modeling of HIV Viral Fitness Experiments: Model Identification, Model Selection, and Multi-Model Inference, Biometrics, 65, 292-300. PMID: 18510656 GUI Tool

Eron, J.J., Park, J.G., Haubrich, R.,  Aweeka, F., Bastow, B., Pakes, G.E., Yu, S., Wu, H., and Richman, D.D. for the ACTG5126 Study Team (2009), Predictive Value of Pharmacokinetic-Adjusted Phenotypic Susceptibility on Response to Ritonavir-Enhanced Protease Inhibitors (PI) in Human Immunodeficiency Virus-Infected Subjects Failing Prior PI Therapy, Antimicrobial Agents and Chemotherapy, 53, 2335-2341. PMID: 19307363

Lee, H.Y., Topham, D.J., Park, S.Y., Hollenbaugh, J., Treanor, J., Mosmann, T.R., Jin, X., Ward, B., Miao, H., Holden-Wiltse, J.,  Perelson, A.S.,  Zand, M.,  Wu, H. (2009), Simulation and Prediction of the Adaptive Immune Response to Influenza A Virus Infection, Journal of Virology, 83, 7151-7165. PMID: 19439465 PMCID: PMC2704765 DataGUI Tool

Lee, H.Y., Hawkins, E., Zand, M.S., Mosmann, T., Wu, H., Hodgkin, P.D., Perelson, A.S. (2009), Interpreting CFSE Obtained Division Histories of B Cells in Vitro with Smith-Martin and Cyton Type Models, Bulletin of Mathematical Biology, 71, 1649-1670. PMID: 19381725


Huang, Y. and Wu, H. (2008), Bayesian Experimental Design for Long-Term Longitudinal HIV Dynamic Studies, Journal of Statistical Planning and Inference, 138, 105-113. PMCID: PMC3225901 Data Fortran Code

Wu, L., Hu, J.X., and Wu, H. (2008), Joint Inference for Nonlinear Mixed-Effects Models and Time to Event at the Presence of Missing Data, Biostatistics, 9(2), 308-320. PMID: 17728318

Chen, J. and Wu, H. (2008), Efficient Local Estimation for Time-varying Coefficients in Deterministic Dynamic Models with Applications to HIV-1 Dynamics, Journal of the American Statistical Association, 103, 369-384. Paper Data VDM_main.c

Wu, H., Zhu, H., Miao, H., and Perelson, A.S. (2008), Parameter Identifiability and Estimation of HIV/AIDS Dynamic Models, Bulletin of Mathematical Biology, 70(3), 785-799. PMID: 18247096

Miao, H., Dykes, C., Demeter, L.M., Cavenaugh, J., Park, S.Y., Perelson, A.S., and Wu, H. (2008), Modeling and Estimation of Kinetic Parameters and Replicative Fitness of HIV-1 from Flow-Cytometry-Based Growth Competition Experiments, Bulletin of Mathematical Biology, 70, 1749-1771. PMID: 18648886 GUI Tool

Chen, J. and Wu, H. (2008), Estimation of time-varying parameters in deterministic dynamic models, Statistica Sinica, 18, 987-1006. Paper Data

Liang, H., Wu, H., Zou, G. (2008), A Note on Conditional AIC for Linear Mixed-Effects Models, Biometrika, 95, 773-778. PMID: 19122890 PMCID: PMC2572765

Huang, Y., Liang, H., and Wu, H. (2008), Identifying significant covariates for anti-HIV treatment response: mechanism-based differential equation models and empirical semiparametric regression models, Statistics in Medicine, 27, 4722-4739. PMID: 18407583 PMCID: PMC2574674

Liang, H., Wu, H., (2008), Parameter Estimation for Differential Equation Models Using a Framework of Measurement Error in Regression Models, Journal of the American Statistical Association, 103, 1570-1583. PMID: 19956350 PMCID: PMC2631937


Jin, X., Wu, H. and Smith, H. (2007), APOBEC3G Levels Predict Rates of Progression to AIDS, Retrovirology, 4:20. Paper PMID: 17374143 PMCID: PMC1832211

Flanigan, R.M., Nawoczenski, D.A., Chen, L., Wu, H., and DiGiovanni, B.F. (2007), The Influence of Foot Position on Stretching of the Plantar Fascia, Foot & Ankle, 28, 815-822. PMID: 17666175

Palumbo, P., Wu, H., Chadwick E. et al. (2007), Virologic Response to Potent Antiretroviral Therapy and Modeling of HIV Dynamics in Early Pediatric Infection, The Journal of Infectious Diseases, 196, 23-29. PMID: 17538879

Wu, H. (2007). Discussion of “Parameter Estimation for Differential Equations: A Generalized Smoothing Approach,” by J. O. Ramsay, G. Hooker, D. Campbell and J. Cao. Journal of the Royal Statistical Society, Ser. B. 69, 789.Paper

Zhu, H. and Wu, H. (2007), Estimation of Smoothing Time-Varying Parameters in State Space Models, Journal of Computational and Graphical Statistics (JCGS), 16(4), 813-832. Paper


Huang, Y. and Wu, H. (2006), “A Bayesian Approach for Estimating Antiviral Efficacy in HIV Dynamic Models," Journal of Applied Statistics, 33, 155-174. Paper Data Fortran Code

Wu, H., Huang, Y., Dykes, C., Liu, D., Ma, J., Perelson, A.S., Demeter, L. (2006), Modeling and Estimation of Replication Fitness of Human Immunodeficiency Virus type 1 in Vitro Experiments Using a Growth Competition Assay, Journal of Virology, 80, 2380-2389. PMID: 16474144 PMCID: PMC1395363

Park, J.G. and Wu, H. (2006), “Backfitting and Local Likelihood Methods for Nonparametric Mixed-Effects Models with Longitudinal Data," Journal of Statistical Planning and Inference, 136, 3760-3782. Paper Data

Huang, Y., Liu, D. and Wu, H. (2006), Hierarchical Bayesian Methods for Estimation of Parameters in a Longitudinal HIV Dynamic System, Biometrics, 62, 413-423. PMID: 16918905 PMCID: PMC2435289 Data Fortran Code Technical Report

Wu, H., Huang, Y. and Acosta, E.P. et al. (2006), Pharmacodynamics of Antiretroviral Agents in HIV-1 Infected Patients Using Viral Dynamic Models That Incorporate Drug Susceptibility and Adherence, Journal of Pharmacokinetics and Pharmacodynamics, 33, 399-419. PMID: 16583266 Data

Liu, D., Yu, J., Reichman, R., Chang, X., Wu, H., Jin, X. (2006), Statistical Determination of Threshold for Cellular Division in the CFSE-Labeling Assay, Journal of Immunological Methods, 312, 126-136. PMID: 16712866

Dykes, C., Wang, J., Jin, X., Planelles, V., An, D.S., Tallo, A., Huang, Y., Wu, H., Demeter, L.M. (2006), Evaluation of a Multiple-Cycle, Recombinant Virus, Growth Competition Assay that Uses Flow Cytometry to Measure Replication Efficiency of Human Immunodeficiency Virus Type 1 in Cell Culture, Journal of Clinical Microbiology, 44, 1930-1943. PMID: 16757582 PMCID: PMC1489405

Treanor, J., Wu, H., Liang, H., and Topham, D.J. (2006), Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults, Vaccine, 24, 6913-6923.PMCID:17014939


Wu, H. (2005), “Statistical Methods for HIV Dynamic Studies in AIDS Clinical Trials," Statistical Methods in Medical Research, 14, 171-192. Paper

Sun, Y. and Wu, H. (2005), “Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data," Scan. J. Statist., 32, 21-47. Paper Data

Wu, H., Huang, Y. and Acosta, E.P. et al. (2005), Modeling Long-Term HIV Dynamics and Antiretroviral Response: Effects of Drug Potency, Pharmacokinetics, Adherence, and Drug Resistance, JAIDS, 39, 272-283. PMID: 15980686 Data GUI Tool


Wu, H. and Liang, H. (2004), “Backfitting Random Varying-Coefficient Models with Time-Dependent Smoothing Covariates," Scan. J. Statist., 31, 3-19. Paper Data S+ code

Wu, H., Lathey, J., Ruan, P., et al. (2004), “Relationship of Plasma HIV-1 RNA Dynamics to Baseline Factors and Virological Responses to Highly Active Antiretroviral Therapy in Adolescents (Aged 12-22 Years) Infected through High-Risk Behavior," Journal of Infectious Diseases, 189, 593-601. PMID: 14767811

Wu, H., Zhao, C. and Liang, H. (2004), “ Comparison of Linear, Nonlinear and Semiparametric Models for Estimating HIV Dynamic Parameters," Biometrical Journal, 46, 233-245.Paper

Acosta, E.P., Wu, H., Hammer, S.M. et al. (2004), “Comparison of Two Indinavir/Ritonavir Regimens in the Treatment of HIV-Infected Individuals," JAIDS, 37, 1358-1366. PMID: 15483465


Liang, H., Wu, H., and Carroll, R.J. (2003), “The Relationship Between Virologic and Immunologic Responses in AIDS Clinical Research Using Mixed-Effects Varying-Coefficient Semiparametric Models with Measurement Error," Biostatistics, 4, 297-312. Paper Data

Hamzeh, F.M., Benson, C., Gerber, J., Currier, J., McCrea, J., Deutsch, P., Ruan, P., Wu, H., Lee, J., Flexner, C. (2003), "Steady-State Pharmacokinetic Interaction of Modified-Dose Indinavir and Rifabutin," Clinical Pharmacology and Therapeutics, 73, 159-169. PMID: 12621381

DiCenzo, R., Forrest, A., Squires, K.E., Hammer, S.M., Fischl, M.A., Wu, H., Cha, R., Morese, G.D. and the Adult AIDS Clinical Trials Group Protocol 368/886 Study Team (2003), “Indinavir, Efavirenz and Abacavir Pharmacokinetics in Human Immunodeficiency Virus-Infected Subjects," Antimicrobial Agents and Chemotherapy, 47, 1929-1935. PMID: 12760869 PMCID: PMC155818

Sun, Y. and Wu, H. (2003), “AUC-Based Tests for Nonparametric Functions with Longitudinal Data," Statistica Sinica, 13, 593-612. Paper

Huang, Y., Rosenkranz, S., Wu, H. (2003), “Modeling HIV Dynamics and Antiviral Responses with Consideration of Time-Varying Drug Exposures, Adherence and Phenotypic Sensitivity," Mathematical Biosciences, 184, 165-186. PMID: 12832146GUI Tool

Wu, H., Mellors, J., Ruan, P. et al. (2003), “Viral Dynamics and Their Relations to Baseline Factors and Longer Term Virologic Responses in Treatment-Naive HIV-1-Infected Patients Receiving Abacavir in Combination with HIV-1 Protease Inhibitors," JAIDS, 32, 557-564. PMID: 12902798

Hass, D.W., Wu, H., Li, H. et al. (2003), “MDR1 Gene Polymorphisms and Phase 1 Viral Decay during HIV-1 Infection: An Adult AIDS Clinical Trials Group Study," JAIDS, 34, 295-298. Paper

Zhang, Y., Liu, W., and Wu, H. (2003), “ A simple nonparametric two-sample test for the distribution function of event time with interval censored data," Journal of Nonparametric Statistics, 15, 643-652.PaperData


Wu, H. and Wu, L. (2002), “Identification of Significant Host Factors for HIV Dynamics Modeled by Nonlinear Mixed-Effect Models," Statistics in Medicine, 21, 753-771. PMID: 11870815 Data

Wu, H. and Ding, A.A. (2002), “Design of Viral Dynamic Studies for Efficiently Assessing Potency of Anti-HIV Therapies in AIDS Clinical Trials," Biometrical Journal, 2, 175-196. Paper

Wu, H. and Zhang, J.T. (2002), “Local Polynomial Mixed-Effects Models for Longitudinal Data," Journal of the American Statistical Association, 97, 883-897.Paper Data

Wu, L. and Wu, H. (2002), “ Missing time-dependent covariates in human immunodeficiency virus dynamic models," Journal of the Royal Statistical Society, Series C (Applied Statistics), 51, 297-318.Paper Data

Wu, H. and Zhang, J.T. (2002), “The Study of Long-Term HIV Dynamics Using Semiparametric Nonlinear Mixed-Effects Models," Statistics in Medicine, 21, 3655-3675. PMID: 12436462 Data


Ding, A.A. and Wu, H. (2001), “Assessing Antiviral Potency of Anti-HIV Therapies in Vivo by Comparing Viral Decay Rates in Viral Dynamic Models," Biostatistics, 2, 13-29 Paper

Wu, H. and Wu, L. (2001), “A Multiple Imputation Method for Missing Covariates in Non-linear Mixed-effects Models with Application to HIV Dynamics," Statistics in Medicine, 20 (12), 1755-1769. PMID: 11406839 Data

Wu, H., Connick E., Kuritzkes, D.R. et al. (2001), “Multiple CD4+ Cell Kinetic Patterns and Their Relationships with Baseline Factors and Virologic Responses in HIV-1 Type 1 Patients Receiving Highly Active Antiretroviral Therapy," AIDS Research and Human Retroviruses, 17(13), 1237-1246. PMID: 11559422


Ding, A.A. and Wu, H. (2000), “A Comparison Study of Models and Fitting Procedures for Biphasic Viral Dynamics in HIV-1 Infected Patients Treated with Antiviral Therapies," Biometrics, 56, 293-300. PMID: 10783809 Data

Kuritzkes, D., Sevin A., Young, B., Bakhtiari, M., Wu, H., Clair, M.S., Connick, E., Landay, A.L., Spritzler, J., Kessler, H., and Lederman, M.M. (2000), “Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315. ACTG Protocol 315 Team.," Journal of Infectious Diseases, 181, 491-497. PMID: 10669331

Wu, H. and Tan, W.Y. (2000), “Modelling the HIV Epidemic: A State-Space Approach," Mathematical and Computer Modelling, 32, 197-215. (Epidemiology Young Investigator Award). Paper


Wu, H. and Ding, A. (1999), “Population HIV-1 Dynamics in Vivo: Applicable Models and Inferential Tools for Virological Data from AIDS Clinical Trials," Biometrics, 55, 410-418. PMID: 11318194 Data

Wu, H., Kuritzkes, D.R., and McClernon, D.R. et al. (1999), “Characterization of Viral Dynamics in Human Immunodeficiency Virus Type 1-Infected Patients Treated with Combination Antiretroviral Therapy: Relationships to Host Factors, Cellular Restoration and Virological Endpoints," Journal of Infectious Diseases, 179(4):799-807. PMID: 10068574 Data

Luzuriaga, K., Wu, H., and McManus, M. et al. (1999), “Dynamics of Human Immunodeficiency Virus Type-1 Replication in Vertically-Infected Infants," Journal of Virology, 73, 362-367. PMID: 9847340 PMCID: PMC103841

Wu, H., Ding, A. and DeGruttola, V. (1999), “Why are the decay rates in plasma HIV-1 different for different treatments and in different patient populations?" AIDS, 13 (3): 429-430. PMID: 10199240

Wu, H. (1999), “How Frequently Should Viral Load be Monitored to Evaluate Antiretroviral Therapies in AIDS Clinical Trials?" Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 20, 97-99. PMID: 9928739

Ding, A.A. and Wu, H. (1999), “Relationships between Antiviral Treatment Effects and Biphasic Viral Decay Rates in Modeling HIV Dynamics," Mathematical Biosciences, 160, 63-82. PMID: 10465932 Data

Wu, H., Ruan, P., Ding, A.A., Sullivan, J.L. and Luzuriaga, K. (1999), “Inappropriate Model-Fitting Methods May Lead To Significant Underestimates of Viral Decay Rates in HIV Dynamic Studies," Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 21, 426-428. PMID: 10458627

Spear, GT, Olinger G, Sullivan B, Landay AL, Kessler, H, Connick E, Kuritzkes D, St. Clair M, Spritzler J, Wu H, Lederman MM (1999) “Alteration of complement protein levels after antiretroviral therapy in HIV-infected persons," AIDS Research and Human Retroviruses, 15, 1713-15. PMID: 10606095


Huffer, F.W. and Wu, H. (1998), “Markov Chain Monte Carlo for Autologistic Regression Models with Application to the Distribution of Plant Species," Biometrics, 54, 509-524. Paper

Tan, W.Y. and Wu, H. (1998),“Stochastic Modeling of the Dynamics of CD4+ T Cell Infection by HIV and some Monte Carlo Studies," Mathematical Biosciences, 147, 173-205. PMID: 9433062

Wu, H., Ding, A. and DeGruttola. V. (1998), “Estimation of HIV Dynamic Parameters," Statistics in Medicine, 17, 2463-2485. PMID: 9819839


Wu, H. and Huffer, F.W. (1997), “Modelling the Distribution of Plant Species Using the Autologistic Regression Model," Environmental and Ecological Statistics, Vol. 4, No.1, 49-64. (First Prize, Student Paper Awards by Section on Statistics and the Environment of ASA) Paper

George, E.O. and Wu, H. (1997), “Testing for Treatment Related Trend with Partially Exchangeable Clustered Data," Biometrics, 53, 479-487. PMID: 9192447