Hongmei Yang, PhDHongmei.Yang

Research Assistant Professor
Ph.D. (2007) North Carolina State University


Contact Information:

University of Rochester
Dept of Biostatistics and Computational Biology
265 Crittenden Boulevard, CU 420630 
Rochester, New York 14642-0630
Office: Saunders Research Building 4148
Phone: (585) 275-0411
Fax: (585) 273-1031
E-mail: Hongmei_Yang@urmc.rochester.edu

Research Interests

My research is practically driven, a combination of active collaborations in HIV, Influenza, and other diseases and independent research. In summary it falls in three areas: statistical processing of assay data (e.g., Elispot, Elisa, and Hemagglutination assays), mixed-effect models for correlated data, and variable selection for high dimensional data.

Selected Publications

  • Fernandez ID; Chin NP; Devine CM; Dozier AM; Martina CA; McIntosh S; Thevenet-Morrison K; Yang H "Images of a Healthy Worksite: A Group-Randomized Trial for Worksite Weight Gain Prevention With Employee Participation in Intervention Design." American journal of public health. 2015; Epub 2015 Mar 19.
  • Yang, H.; Baker, S.F.; González, M.E.; Topham, D.J.; Martínez-Sobrido, L.; Zand, M.; Holden-Wiltse, J; Wu, H. "An Improved Method for Estimating Antibody Titers in Microneutralization Assay Using Green Fluorescent Protein". Journal of Biopharmaceutical Statistics. 2015. In press
  • Halliley, J.L.; Khurana, S.; Krammer, F.; Fitzgerald, T.; Coyle, E.M.; Chung, K.Y.; Baker, S.F.; Yang, H.; Martínez-Sobrido, L.; Treanor, J.J.; Subbarao, K.; Golding, H.; Topham, D.J.; Sangster, M. "High Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine after Priming with Live Attenuated Influenza Vaccine". Journal of Infectious Diseases. 2015. In press
  • Nayak JL; Richards KA; Yang H; Treanor JJ; Sant AJ "Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses." The Journal of infectious diseases. 2014; Epub 2014 Nov 06.
  • Dozier AM; Brownell E; Guido J; Yang H; Howard CA; Doniger A; Ossip D; Lawrence R "Adapting the pregnancy risk assessment monitoring survey to enhance locally available data: methods." Maternal and child health journal. 2014; 18(5):1196-204.
  • Kwara A; Cao L; Yang H; Poethke P; Kurpewski J; Tashima KT; Mahjoub BD; Court MH; Peloquin CA "Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance." Pharmacotherapy. 2014; 34(3):265-71.
  • Lerman YV; Lim K; Hyun YM; Falkner KL; Yang H; Pietropaoli AP; Sonnenberg A; Sarangi PP; Kim M "Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent." Blood. 2014; 124(24):3515-23.
  • Luque AE; Orlando MS; Leong UC; Allen PD; Guido JJ; Yang H; Wu H "Hearing function in patients living with HIV/AIDS." Ear and hearing. 2014; 35(6):e282-90.
  • Wang J; Li D; Bambara RA; Yang H; Dykes C "L74V increases the reverse transcriptase content of HIV-1 virions with non-nucleoside reverse transcriptase drug-resistant mutations L100I+K103N and K101E+G190S, which results in increased fitness." The Journal of general virology. 2013; 94(Pt 7):1597-607.
  • Sangster MY; Baer J; Santiago FW; Fitzgerald T; Ilyushina NA; Sundararajan A; Henn AD; Krammer F; Yang H; Luke CJ; Zand MS; Wright PF; Treanor JJ; Topham DJ; Subbarao K "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI. 2013; 20(6):867-76.
  • Nayak JL; Fitzgerald TF; Richards KA; Yang H; Treanor JJ; Sant AJ "CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine." The Journal of infectious diseases. 2013; 207(2):297-305.
  • Weaver JM; Yang H; Roumanes D; Lee FE; Wu H; Treanor JJ; Mosmann TR "Increase in IFN?(-)IL-2(+) cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza." PloS one. 2013; 8(3):e57275.
  • Yang H; Topham DJ; Holden-Wiltse J; Wu H "Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays." Journal of biopharmaceutical statistics. 2013; 23(4):921-36.
  • Henn AD; Wu S; Qiu X; Ruda M; Stover M; Yang H; Liu Z; Welle SL; Holden-Wiltse J; Wu H; Zand MS "High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature." Scientific reports. 2013; 3():2327.
  • Mapstone M; Hilton TN; Yang H; Guido JJ; Luque AE; Hall WJ; Dewhurst S; Shah K "Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults." Aging and disease. 2013; 4(6):311-9.
  • Henn, A.D., Laski, M., Yang, H., Qiu, X., Miao, H., Barry, C.T.,Welle, S.,Wu, H. and Zand, M.S. (2012) Functionally Distinct Subpopulations of CpG-Activated Memory B Cells. Nature Scientific Reports. doi:10.1038/srep00345.
  • Sundararajan, A., Huan, L., Richards, K.A., Marcelin, G., Alam, S., Joo, H., Yang, H., Webby, R.J., Topham, D.J., Sant, A.J. and Sangster, M.Y. (2012) Host Differences in Influenza-Specific CD4 T Cell and B Cell Responses are Modulated by Viral Strain and
    Route of Immunization. PLoS One. 2012;7(3):e34377.
  • Lartey M, Sagoe KW, Yang H, Kenu E, Xexemeku F, Oliver-Commey J, Boima V, Seshie M, Sagoe A, Mingle JAA, Flanigan TP, Wu H, Kwara A (2011). Viral Decay Rates are Similar in HIV-infected Patients with and without TB Coinfection during Treatment with an Efavirenz-based Regimen. Clinical Infectious Diseases 52(4): 547-550.

  • Quách TD, Manjarrez-Orduño N, Adlowitz DG, Silver L, Yang H, Wei C, Milner EC, Sanz I (2011). Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM. Journal of Immunology 186(8):4640-8. Epub 2011 Mar 11.
  • Barnett S, Klein JD, Pollard Jr RQ, Samar V, Schlehofer D, Starr M, Sutter E, Yang H, Pearson TA (2011). Community participatory research with deaf sign language users to identify health inequities. American Journal of Public Health 101(12):2235-8. Epub 2011 Oct 20.
  • Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ (2010). B Cell Responses to H5 Influenza HA in Human Subjects Vaccinated with Drifted Variants. Vaccine 28(4): 907-915.
  • Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE (2009). Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells. Journal of Immunological Methods 340(1):42-7.