Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients
With Newly Diagnosed WNT-Driven Medulloblastoma
Does reducing the amount of radiation therapy a person gets help reduce side effects
in patients with medulloblastoma?
Basic Study Information
Purpose:Location: University of Rochester
This phase II trial studies how well reduced doses of radiation therapy to the brain
spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed
brain tumor called WNT/Wingless (WNT)-driven medulloblastoma. Recent studies using
chemotherapy and radiation therapy have been shown to be effective in treating patients
WNT-driven medulloblastoma. However, there is a concern about the late side effects
treatment, such as learning difficulties, lower amounts of hormones, or other problems
performing daily activities. Radiotherapy uses high-energy radiation from x-rays to
cancer cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, vincristine
sulfate, cyclophosphamide and lomustine, work in different ways to stop the growth
cells, either by killing the cells, by stopping them from dividing, or by stopping
spreading. Giving reduced craniospinal radiation therapy and chemotherapy may kill
cells and may also reduce the late side effects of treatment.
Lead Researcher (Principal Investigator)
Study Contact InformationPhone: (585) 275-5830
Additional Study Details
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