A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic
Leukemia
Research Question:
What is the efficacy of combination chemotherapy and ruxolitinib for the treatment
of B-cell acute lymphoblastic leukemia in children?
Basic Study Information
Purpose:
This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent
chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part
1 of the
study will optimize the dose of study drug (ruxolitinib) in combination with the chemotherapy
regimen. Part 2 will evaluate the efficacy of combination chemotherapy and ruxolitinib
at the
recommended dose determined in Part 1.
Location: University of Rochester Medical Center
Lead Researcher (Principal Investigator)
Lead Researcher:
Angela Girvin
Study Contact Information
Additional Study Details
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