Acute Myeloid Leukemia (AML): Study of Crenolanib vs Midostaurin Following Induction
Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Does the drug Crenolanib help the survival of AML patients better than the drug Midostaurin?
Basic Study Information
Purpose:Location: University of Rochester Medical Center
A phase III randomized multi-center study designed to compare the efficacy of crenolanib
with that of midostaurin when administered following induction chemotherapy, consolidation
chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with
FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either
crenolanib in addition to standard first line treatment of AML (chemotherapy and if
eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B).
Potentially eligible subjects will be registered and tested for the presence of FLT3
mutation. Once the FLT3 mutation status is confirmed and additional eligibility is
established, subject will be randomized and enter into the treatment phase.
Study Reference #: ILEU 17106
Lead Researcher (Principal Investigator)
Jane Liesveld, MD
Study Contact Information
Additional Study Details
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