Radiation Therapy and Cisplatin With or Without Triapine in Treating Patients With
Newly Diagnosed Stage IB2, II, or IIIB-IVA Cervical Cancer or Stage II-IVA Vaginal
How well does radiation therapy and cisplatin with triapine work compared to the standard
radiation therapy and cisplatin alone in treating patients with newly diagnosed stage
IB2, II, or IIIB-IVA cervical cancer or stage II-IVA vaginal cancer?
Basic Study Information
Purpose:Location: University of Rochester Medical Center
This randomized phase III trial studies radiation therapy and cisplatin with triapine
to see how well they work compared to the standard radiation therapy and cisplatin
alone in treating patients with newly diagnosed stage IB2, II, or IIIB-IVA cervical
cancer or stage II-IVA vaginal cancer. Radiation therapy uses high energy protons
to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin,
work in different ways to stop the growth of tumor cells, either by killing the cells,
by stopping them from dividing, or by stopping them from spreading. Triapine may stop
the growth of tumor cells by blocking some of the enzymes needed for cell growth.
It is not yet known whether radiation therapy and cisplatin are more effective with
triapine in treating cervical or vaginal cancer.
Study Reference #: CGYC16057
Lead Researcher (Principal Investigator)
Lead Researcher: Richard Moore
Study Contact InformationStudy Coordinator: Laura Mitchell
Additional Study Details
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