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Visualizing Hand/Finger Joints Using Florescence Imaging

Research Question:
Can NIR-ICG (InfraRed Indocyanine Green) florescence imaging visualize lymphatics vessels (not veins) and observe lymphatic transport in healthy hand/finger joints?

Basic Study Information

Purpose:
Lymphatic transport will be examined using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) and magnetic resonance lymphography (MRL) of the upper extremities, including hands/fingers. The study will 1) compare imaging of lymphatic vessels with NIR-ICG versus MRL using intradermal injections (just under the skin); 2) compare clearance of lymphatic fluid from joints visualized with NIR-ICG versus MRL using joint injections, and 3) gather adequate estimates of variability to permit power calculations for future, larger scale studies. Participants must be 18 years old or older. Participation includes up to four study visits.

Location: University of Rochester
Study Reference #: STUDY3891

Lead Researcher (Principal Investigator)

Lead Researcher: Homaira Rahimi

Study Contact Information

Study Coordinator: Amy Wielgosz, RN
Phone: (585) 275-1035
Email: amy_wielgosz@urmc.rochester.edu

Additional Study Details

Study Details:
Healthy subjects taking part in the study will have an initial study visit (visit 1) involving intradermal injection of ICG and will be imaged with the NIR camera. The subject will return within one week + 7 days /- 2 days (visit 2) and receive IV iron contrast, intradermal Gd injections, and imaged via MRI. The subject will return at a minimum of 8 weeks later for intra-articular ICG injections and imaging via the NIR camera (visit 3). There is no maximum visit window for patients to return for visit 3. About one week later +7 days /- 2 days (visit 4), the subject will return for IV iron contrast, intra-articular Gd injections, and imaging via MRI. At visit 2 and visit 4, the subject may be asked to have a brief NIR imaging session to determine clearance of ICG from the previous visit. Patients who do not complete visit 3 will not be asked to participate in visit 4. However, if a patient misses or does not complete visit 1 or 2 for any reason, they may still participate in visit 3 & 4. If optimal images are not achieved during visit 1 or 3, the patient may be asked to return for a repeat visit.

Number of Visits:  2 to 5
Parking:  Free
Transportation Coverage:  No
Reimbursement:  Yes

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