Visualizing Hand/Finger Joints Using Florescence ImagingResearch Question:
Can NIR-ICG (InfraRed Indocyanine Green) florescence imaging visualize lymphatics
vessels (not veins) and observe lymphatic transport in healthy hand/finger joints?
Basic Study Information
Purpose:Location: University of Rochester
Lymphatic transport will be examined using Near InfraRed Indocyanine Green fluorescence
imaging (NIR-ICG) and magnetic resonance lymphography (MRL) of the upper extremities,
including hands/fingers. The study will 1) compare imaging of lymphatic vessels with
NIR-ICG versus MRL using intradermal injections (just under the skin); 2) compare
clearance of lymphatic fluid from joints visualized with NIR-ICG versus MRL using
joint injections, and 3) gather adequate estimates of variability to permit power
calculations for future, larger scale studies. Participants must be 18 years old or
older. Participation includes up to four study visits.
Study Reference #: STUDY3891
Lead Researcher (Principal Investigator)
Lead Researcher: Homaira Rahimi
Study Contact InformationStudy Coordinator: Amy Wielgosz, RN
Phone: (585) 275-1035
Additional Study Details
Healthy subjects taking part in the study will have an initial study visit (visit
1) involving intradermal injection of ICG and will be imaged with the NIR camera.
The subject will return within one week + 7 days /- 2 days (visit 2) and receive IV
iron contrast, intradermal Gd injections, and imaged via MRI. The subject will return
at a minimum of 8 weeks later for intra-articular ICG injections and imaging via the
NIR camera (visit 3). There is no maximum visit window for patients to return for
visit 3. About one week later +7 days /- 2 days (visit 4), the subject will return
for IV iron contrast, intra-articular Gd injections, and imaging via MRI. At visit
2 and visit 4, the subject may be asked to have a brief NIR imaging session to determine
clearance of ICG from the previous visit. Patients who do not complete visit 3 will
not be asked to participate in visit 4. However, if a patient misses or does not
complete visit 1 or 2 for any reason, they may still participate in visit 3 & 4. If
optimal images are not achieved during visit 1 or 3, the patient may be asked to return
for a repeat visit.
Number of Visits:
2 to 5
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