DRO 70001/ Cognitive changes in patients receiving partial brain radiation/ Michael
Basic Study Information
Purpose:Location: James P. Wilmot Cancer Center at University of Rochester Medical Center
Cranial radiation therapy (RT), commonly used to treat benign and malignant brain
tumors, can lead to cognitive impairments in domains not related to neuroanatomic
structures directly impacted by the tumor. The study will prospectively enroll 58
patients with benign and low-grade brain tumors who will undergo partial brain RT,
with either conventionally fractionated or hypofractionated schedules. Subjects will
receive MRI scans at baseline and 6 months. Given the role of the limbic system in
key cognitive functions affected by RT, researchers have a particular interest in
characterizing MRI changes in the limbic system and thalamus in relation to memory
and related processes.
To examine objective neurocognitive changes over time. The investigators hypothesize
that they will see RT-induced neurocognitive impairment in up to 50% of patients after
To examine changes in brain tissue (via MRI) induced by off-target RT in patients
with benign and low-grade brain tumors. The investigators specifically hypothesize
that comapping of RT dose and MRI changes in the thalamus and limbic system (i.e.,
thalamic nuclei, hippocampus, fornix, hypothalamus/mammillary bodies, limbic lobe,
cingulum) will be most distorted by off-target RT.
To examine the relationship between MRI changes for key neuroanatomic structures identified
in Aim 1 with objective neurocognitive testing. The investigators hypothesize that
cognitive decline will be correlated with damage revealed by MRI to limbic and thalamic
This research will help to define which neuroanatomic structures are most at risk
from RT-induced damage and will help ultimately establish new dose constraint guidelines
for important structures to improve cognitive outcomes.
Lead Researcher (Principal Investigator)
Study Contact InformationStudy Coordinator: Deborah Lamay
Additional Study Details
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