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URMC / Research / Clinical Trials / Study Details

PLEU19018 / PBMTC ONC1701/ Jeffrey Andolina

Research Question:
Is not providing total body irradiation in B cell ALL patients effective before the patient receives a stem cell transplant?

Basic Study Information

Purpose:
This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive will be treated as per treating center standard and will be followed in an observational cohort (HCT center standard of care).

Location: University of Rochester Medical Center
Study Reference #: PLEU19018

Lead Researcher (Principal Investigator)

Lead Researcher:  Jeffrey Andolina

Study Contact Information

Study Coordinator: Amber Johnson
Email: amber_johnson@urmc.rochester.edu

Additional Study Details

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