PLEU19018 / PBMTC ONC1701/ Jeffrey AndolinaResearch Question:
Is not providing total body irradiation in B cell ALL patients effective before the
patient receives a stem cell transplant?
Basic Study Information
Purpose:Location: University of Rochester Medical Center
This study will evaluate the use of non- TBI (total body irradiation) conditioning
for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next
generation sequencing minimal residual disease) before receiving a hematopoietic cell
transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will be
screened by NGS-MRD on a test of bone marrow done before the HCT. Subjects who are
pre-HCT NGS-MRD negative will be eligible to receive a non-TBI conditioning regimen
as part of the treatment cohort of the study. Subjects who are pre-HCT NGS-MRD positive
will be treated as per treating center standard and will be followed in an observational
cohort (HCT center standard of care).
Study Reference #: PLEU19018
Lead Researcher (Principal Investigator)
Study Contact InformationStudy Coordinator: Amber Johnson
Additional Study Details
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