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IGUB20054, Fung, SGN22E-002, Urothelial Cancer, enfortumab vedotin (EV), pembrolizumab

Research Question:
How well does an experimental drug (enfortumab vedotin) work alone and with different combinations of anticancer therapies?

Basic Study Information

Purpose:
This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra. Some parts of the study will look at locally-advanced and metastatic urothelial cancer, which means the cancer has spread to nearby tissues or to other areas of the body. Other parts of the study will look at muscle-invasive bladder cancer (MIBC), which is cancer at an earlier stage that has spread into the muscle wall of the bladder. This study will look at the side effects of enfortumab vedotin alone and with other anticancer therapies. A side effect is a response to a drug that is not part of the treatment effect. This study will also test if the cancer shrinks with the different treatment combinations.

Location: University of Rochester Medical Center
Study Reference #: IGUB20054

Lead Researcher (Principal Investigator)

Lead Researcher:  Chunkit Fung

Study Contact Information

Study Coordinator: Tina Bowdish
Phone: +1 585-275-9475
Email: tina_bowdish@urmc.rochester.edu

Additional Study Details

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