Women diagnosed with breast cancer experience considerable psychological stress, but the impact of such stress on tumor progression is not well understood. The overall objective of my research is to identify mechanisms whereby neurohormones released with stress exposure interact with tumor cells and non-tumor stromal cell populations to regulate cancer progression. Our laboratory has discovered that elevated norepinephrine or activation of selective adrenergic receptors can promote tumor progression and metastasis in association with altered fibrillar collagen microstructure, as detected optically in the tumor by multiphoton second harmonic generation (SHG) imaging. One goal of this line of investigation is to determine if stress-induced elevation in metastatic potential can be detect by SHG imaging of the tumor extracellular environment. We have also begun to investigate the novel idea that psychological stress exposure promotes metastasis by modulating tumor release of exosomes, a newly discovered mechanism to promote tumor cell metastasis. Ultimately, this research will lead to new therapeutic options in treating breast cancer patients.
Madden KS. "Sympathetic neural-immune interactions regulate hematopoiesis, thermoregulation and inflammation in mammals." Developmental and comparative immunology.. 2017 Jan 0; 66:92-97. Epub 2016 Apr 24.
Ramirez G, Proctor AR, Jung KW, Wu TT, Han S, Adams RR, Ren J, Byun DK, Madden KS, Brown EB, Foster TH, Farzam P, Durduran T, Choe R. "Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy." Biomedical optics express. 2016 Sep 1; 7(9):3610-3630. Epub 2016 Aug 24.
Szpunar MJ, Belcher EK, Dawes RP, Madden KS. "Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer." Brain, behavior, and immunity.. 2016 Mar 0; 53:223-233. Epub 2015 Dec 21.
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