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James Palis, M.D.
James Palis, M.D.

James Palis, M.D.

Pediatrics

Not Accepting New Patients

James Palis, M.D.

Pediatrics

Not Accepting New Patients


Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester, NY 14642
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phone

Appointments

(585) 275-2981

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Fax

(585) 276-0233

About Me

Pediatric Hematology and Oncology

Credentials

Education:

MD | Univ. of Rochester School of Medicine and Dentistry — 1981

Post-doctoral Training & Residency:

Fellowship in Pediatric Hematology/Oncology at Golisano Children's Hospital at Strong Memorial — 1984 - 1988
Internship in Pediatrics at Golisano Children's Hospital at Strong Memorial — 1981 - 1982
Residency in Pediatrics at Golisano Children's Hospital at Strong Memorial — 1982 - 1984

Research

Dr. Palis' research interests are:
1) Ontogeny of the mammalian hematopoietic system,
2) Differentiation of the erythroid lineage,
3) Erythroid precursor self-renewal, and
4) Response of the hematopoietic system to ionizing radiation

Hematopoietic stem cells responsible for the production of blood cells throughout life arise during embryogenesis. However, the mechanisms that initiate blood cell development are largely unknown. The long-term aim of Dr. Palis' laboratory is to elucidate the cellular and molecular events underlying the initiation of hematopoiesis in the mammalian embryo. The first hematopoietic cells to emerge during mammalian embryogenesis are "primitive" red cells that are necessary for survival of the fetus. Their recent studies indicate that the primitive erythroid lineage in mice as "mammalian", rather than "non-mammalian" in character. Primitive erythropoiesis will thus serve as an important model of mammalian erythroid differentiation. Hematopoiesis originates in the yolk sac of embryos and transitions to the liver of the fetus. Two waves of hematopoietic progenitors have been identified in the yolk sac prior to colonization of the liver and the lineage composition and relationships of these primitive and definitive progenitor waves are under active investigation. Their studies indicate that the onset of hematopoiesis within the yolk sac of mammals is much more complex than previously thought.

The hematopoietic system of the adult is exquisitely sensitive to xenotoxic insults. The Palis laboratory is investigating the response of the erythroid and megakaryocyte lineages to ionizing radiation. These studies will provide for the rational use of cytokines and other agents to mitigate the deleterious effects of external radiation.

An understanding of the ontogeny of mammalian hematopoiesis and its response to damage will ultimately produce insights into the regulation and expansion of hematopoietic stem cells. These insights will also lead to a better understanding of genetic disorders, bone marrow failure syndromes and leukemias, ultimately leading to improvements in bone marrow transplantation for the curative treatment of numerous congenital anemias, genetic diseases, and several forms of childhood and adult cancers.

Publications:

Peraki I, Palis J, Mavrothalassitis G. "The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis." Molecular and cellular biology.. 2017 Oct 1; 37(19)Epub 2017 Sep 12.

Huang YS, Delgadillo LF, Cyr KH, Kingsley PD, An X, McGrath KE, Mohandas N, Conboy JG, Waugh RE, Wan J, Palis J. "Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating." Scientific reports.. 2017 Jul 12; 7(1):5164. Epub 2017 Jul 12.

McGrath KE, Catherman SC, Palis J. "Delineating stages of erythropoiesis using imaging flow cytometry." Methods : a companion to Methods in enzymology.. 2017 Jan 1; 112:68-74. Epub 2016 Aug 28.

View All Publications

Links:

Palis Lab