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Chawnshang Chang, Ph.D.
Chawnshang Chang, Ph.D.

Chawnshang Chang, Ph.D.

Accepting New Patients

Chawnshang Chang, Ph.D.

Accepting New Patients


Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642
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phone

Appointments

(585) 275-8762

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Fax

(585) 756-4133

About Me

Dr. Chang is Director of the George H. Whipple Laboratory for Cancer Research. He is an internationally-recognized expert in the role of androgen receptor in prostate cancer and other organs and diseases. Androgens (steroid hormones) control the development and function of male reproductive tissues, and also influence other organs and tissues, such as skin, skeletal muscle, bone marrow, hair follicles, and brain. Androgen regulates gene expression through the androgen receptor.

In 1988, Dr. Chang became the first scientist to clone the complete human and rat androgen receptors. (Science, 1988; PNAS, 1988). He then applied recombinant techniques to overexpress a large quantity of androgen receptor (AR) and used it to produce the first monoclonal antibody to the androgen receptor (Endo., 1989). The successful cloning of the androgen receptor and the generation of the first androgen receptor monoclonal antibody were groundbreaking. Dr. Chang has continued his research in this field; has had more than 200 papers published on the roles of AR, TR2 and TR4; and has served as a mentor to numerous graduate students, postdoctoral fellows, and junior faculty.

Research

The George H. Whipple Lab for Cancer Research's interest is mainly in the sex hormones/nuclear receptors and Vitamin D/E effects on the prostate/bladder cancer and other hormone-related diseases.

Additional information on publications and details of Dr. Chawnshang Chang's research can be obtained from his lab website listed below.

Publications:

Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C. "Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status." Oncotarget. 2015 Oct 13; 6(31):31203-15.

Ou Z, Wang Y, Liu L, Li L, Yeh S, Qi L, Chang C. "Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals." Oncotarget. 2015 Sep 22; 6(28):26065-78.

Xie H, Li L, Zhu G, Dang Q, Ma Z, He D, Chang L, Song W, Chang HC, Krolewski JJ, Nastiuk KL, Yeh S, Chang C. "Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-?1/Smad/MMP9 signals." Oncotarget. 2015 May 20; 6(14):12326-39.

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Links:

The George H. Whipple Lab for Cancer Research was established in 1997 with the recruitment of Dr. Chawnshang Chang as the Founder and current Director.