Dr. Edward Schwarz is the Burton Professor of Orthopaedics and Director of the Center for Musculoskeletal Research at the University of Rochester Medical Center, in Rochester, NY. His laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis and wear debris-induced osteolysis around loose prosthetic implants.
Dr. Schwarz is also a leader in orthopaedic biologic therapy and stem cell research, for which his lab has developed a novel passive immunization for MRSA and revitalizing allograft approaches for bone and tendon regeneration.
Dr. Schwarz's lab is also interested in developing translational in vivo imaging outcome measures include near infrared imaging of lymphatic flow to detect arthritic flare, and cone beam CT to assess bone healing in patients with orthopaedic implants. More recently, Dr. Schwarz's lab has combined these biologic therapy technologies and outcome measures with biocompatible carriers and stem cells to generate novel tissue engineering constructs for bone, cartilage, ligament and tendon.
Ishikawa M, de Mesy Bentley KL, McEntire BJ, Bal BS, Schwarz EM, Xie C. "Surface topography of silicon nitride affects antimicrobial and osseointegrative properties of tibial implants in a murine model." Journal of biomedical materials research. Part A.. 2017 Sep 2; Epub 2017 Sep 02.
Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM. "Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Sep 0; 32(9):1870-1883. Epub 2017 Jul 19.
Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM. "Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress." Arthritis & rheumatology.. 2017 Jun 0; 69(6):1187-1193. Epub 2017 Apr 04.
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