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Joe V. Chakkalakal, Ph.D.

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Appointment: (585) 276-3000

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Faculty Appointments



Dr. Joe Chakkalakal is a Dean's Associate Professor in the Department of Pharmacology and Physiology affiliated with the Wilmot Cancer Center at the University Rochester Medical Center. His laboratory is interested in the contribution of stem cells to the maturation, regeneration, and lifelong maintenance of skeletal muscle in various contexts including juvenile growth, aging, and cancer survivorship.

Through the use of conditional genetic strategies Dr. Chakkalakal's lab has uncovered niche derived signals responsible for the age-related decline of skeletal muscle resident stem cells. More recently, the Chakkalakal lab has found resident stem cell loss or gain is associated with earlier onset or attenuation of age-related skeletal muscle decline respectively. Dr. Chakkalakal's lab is interested in building on these observations to:

1. Uncover how resident stem cell manipulation affects specific aspects of skeletal muscle biology in models of post-natal maturation, aging, accelerated aging and cancer survivorship

2. Identify therapies that promote resident stem cell maintenance and function


Journal Articles

Liu W, Chakkalakal JV. "The Composition, Development, and Regeneration of Neuromuscular Junctions." Current topics in developmental biology.. 2018 126:99-124. Epub 2017 Nov 10.

Klose A, Liu W, Paris ND, Forman S, Krolewski JJ, Nastiuk KL, Chakkalakal JV. "Castration induces satellite cell activation that contributes to skeletal muscle maintenance." JCSM rapid communications.. 2018 1(1)

Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG. "Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia." Current opinion in supportive and palliative care.. 2017 Dec 0; 11(4):278-286.