Vyacheslav (Slava) A. Korshunov, Ph.D.
Associate Professor, Department of Medicine, Aab Cardiovascular Research Institute
Associate Professor, Department of Biomedical Genetics (SMD)
2000 | Ph.D. in Pharmaceutical Sciences (Pharmacology) | Pyatigorsk State Academy of Pharmacy
1999 | Masters in Biology | Puschino State University, Pharmacology Group
1997 | Diploma in Pharmacy with Honor | Pyatigorsk State Academy of Pharmacy
Understanding the mechanisms that regulate the structure of blood vessels will decrease cardiovascular morbidity and mortality in humans. My current research focuses on immune mechanisms of cardiovascular disorders that affect vascular remodeling and high blood pressure.
My laboratory research has three directions:
We are working on a project that explores the role of Axl, a receptor tyrosine kinase, in regulation of the immune responses in hypertension. Using state-of-the-art flow cytometry techniques we found that expression of Axl affected accumulation of leukocytes in the kidneys and determined pathogenesis of early phase of deoxycorticosterone-acetate and salt hypertension in mice. We also found that Axl regulates vascular remodeling by promoting immune activation of smooth muscle cells in a mouse model of vein graft (Figure).
Our most recent paper shows that Axl requires for survival of adaptive immune cells and vascular remodeling in hypertension.
We study genetic mechanisms that lead to differences between physiological and pathological carotid artery remodeling. We discovered a new candidate gene that regulates arterial rigidity and arterial stenosis; we are currently defining the biomechanical pathways through which this gene regulates pathological remodeling
We used a combined genetic approach of genome-wide linkage and association analyses to identify a novel locus on mouse chromosome 7 that controls elevated heart rate and vascular remodeling. Our most recent findings suggest that autonomic dysfunction is crucial for stress-induced vascular inflammation in mice. We are studying candidate genes within chromosome 7 locus that control hemodynamic parameters and vascular inflammation.
Batchu SN, Hughson A, Wadosky KM, Morrell CN, Fowell DJ, Korshunov VA. Role of Axl in T-lymphocyte survival in salt-dependent hypertension. Arterioscler Thromb Vasc Biol 2016;36(8):1638-46.
Batchu SN, Xia J, Ko KA, Doyley MM, Abe J, Morrell CN, Korshunov VA. Axl modulates immune activation of smooth muscle cells in vein graft remodeling. Am J Physiol Heart Circ Physiol 2015;309(6):H1048-58.
Batchu SN, Smolock EM, Dyachenko IA, Murashev AN, Korshunov VA. Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. J Am Heart Assoc 2015;4:e001952.
Smolock EM, Burke R, Wang C, Batchu SN, Qiu X, Thomas T, Zettel M, Fujiwara K, Berk BC, Korshunov VA. Intima modifier locus 2 controls endothelial cell activation and vascular permeability. Physiol Genomics 2014;46(17):624-633.
Batchu SN, Hughson A, Gerloff J, Fowell DJ, Korshunov VA. Role of Axl in early kidney inflammation and development of salt-dependent hypertension. Hypertension 2013;62(2):302-309.
Smolock EM, Ilyushkina IA, Ghazalpour A, Gerloff J, Murashev AN, Lusis AJ, Korshunov VA. Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiol Genomics 2012;44(13):689-98.
Gerloff J and Korshunov VA. Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening. Am J Pathol 2012;180(5):2134-43.
Graduate Program Affiliation
Genetics, Development, and Stem Cells (GDSC)
The Korshunov Lab is currently recruiting Graduate Students