Recent Publications

• 1. Braun C
  2. Parks XX
  3. Qudsi H
  4. Lopes CM
  PKCβII specifically regulates KCNQ1/KCNE1 channel membrane localization.; Journal of molecular and cellular cardiology; Vol 138. 2020 Jan.
• 1. Ronzier E
  2. Parks XX
  3. Qudsi H
  4. Lopes CM
  Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization.; Scientific reports; Vol 9(1). 2019 Nov 28.
• 1. Parks XX
  2. Ronzier E
  3. O-Uchi J
  4. Lopes CM
  Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca2+-dependent PKC activation.; Journal of molecular and cellular cardiology; Vol 129. 2019 Apr.
• 1. Bookstaver PB
  2. Jenkins TC
  3. Stenehjem E
  4. Doron S
  5. Brown J
  6. Goldwater SH
  7. Lopes C
  8. Haynes A
  9. Udeze C
  10. Mo Y
  11. Gillard P
  12. Liu Y
  13. Keyloun K
  Impact of Outpatient vs Inpatient ABSSSI Treatment on Outcomes: A Retrospective Observational Analysis of Medical Charts Across US Emergency Departments.; Open forum infectious diseases; Vol 5(7). 2018 Jul.
• 1. Kutyifa V
  2. Daimee U
  3. McNitt S
  4. Polonsky B
  5. Lowenstein C
  6. Cutter K
  7. Lopes C
  8. Zareba W
  9. Moss AJ
  Clinical aspects of the three major genetic forms of long QT syndrome (LQT1, LQT2, LQT3).; Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2018 Mar 05.
• 1. Roberts JD
  2. Krahn AD
  3. Ackerman MJ
  4. Rohatgi RK
  5. Moss AJ
  6. Nazer B
  7. Tadros R
  8. Gerull B
  9. Sanatani S
  10. Wijeyeratne YD
  11. Baruteau AE
  12. Muir AR
  13. Pang B
  14. Cadrin-Tourigny J
  15. Talajic M
  16. Rivard L
  17. Tester DJ
  18. Liu T
  19. Whitman IR
  20. Wojciak J
  21. Conacher S
  22. Gula LJ
  23. Leong-Sit P
  24. Manlucu J
  25. Green MS
  26. Hamilton R
  27. Healey JS
  28. Lopes CM
  29. Behr ER
  30. Wilde AA
  31. Gollob MH
  32. Scheinman MM
  Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?; Circulation. Arrhythmia and electrophysiology; Vol 10(8). 2017 Aug.
• 1. Wilde AA
  2. Moss AJ
  3. Kaufman ES
  4. Shimizu W
  5. Peterson DR
  6. Benhorin J
  7. Lopes C
  8. Towbin JA
  9. Spazzolini C
  10. Crotti L
  11. Zareba W
  12. Goldenberg I
  13. Kanters JK
  14. Robinson JL
  15. Qi M
  16. Hofman N
  17. Tester DJ
  18. Bezzina CR
  19. Alders M
  20. Aiba T
  21. Kamakura S
  22. Miyamoto Y
  23. Andrews ML
  24. McNitt S
  25. Polonsky B
  26. Schwartz PJ
  27. Ackerman MJ
  Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.; Circulation; Vol 134(12). 2016 Sep 20.
• 1. Ruwald MH
  2. Xu Parks X
  3. Moss AJ
  4. Zareba W
  5. Baman J
  6. McNitt S
  7. Kanters JK
  8. Shimizu W
  9. Wilde AA
  10. Jons C
  11. Lopes CM
  Stop-codon and C-terminal nonsense mutations are associated with a lower risk of cardiac events in patients with long QT syndrome type 1.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 13(1). 2016 Jan.
• 1. O-Uchi J
  2. Sorenson J
  3. Jhun BS
  4. Mishra J
  5. Hurst S
  6. Williams K
  7. Sheu SS
  8. Lopes CM
  Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.; Biochemical and biophysical research communications; Vol 465(3). 2015 Sep 25.
• 1. O-Uchi J
  2. Rice JJ
  3. Ruwald MH
  4. Parks XX
  5. Ronzier E
  6. Moss AJ
  7. Zareba W
  8. Lopes CM
  Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.; Journal of molecular and cellular cardiology; Vol 79. 2015 Feb.
• 1. Mathias A
  2. Moss AJ
  3. Lopes CM
  4. Barsheshet A
  5. McNitt S
  6. Zareba W
  7. Robinson JL
  8. Locati EH
  9. Ackerman MJ
  10. Benhorin J
  11. Kaufman ES
  12. Platonov PG
  13. Qi M
  14. Shimizu W
  15. Towbin JA
  16. Michael Vincent G
  17. Wilde AA
  18. Zhang L
  19. Goldenberg I
  Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 10(5). 2013 May.
• 1. Mullally J
  2. Goldenberg I
  3. Moss AJ
  4. Lopes CM
  5. Ackerman MJ
  6. Zareba W
  7. McNitt S
  8. Robinson JL
  9. Benhorin J
  10. Kaufman ES
  11. Towbin JA
  12. Barsheshet A
  Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 10(3). 2013 Mar.
• 1. Hoefen R
  2. Reumann M
  3. Goldenberg I
  4. Moss AJ
  5. O-Uchi J
  6. Gu Y
  7. McNitt S
  8. Zareba W
  9. Jons C
  10. Kanters JK
  11. Platonov PG
  12. Shimizu W
  13. Wilde AA
  14. Rice JJ
  15. Lopes CM
  In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models.; Journal of the American College of Cardiology; Vol 60(21). 2012 Nov 20.
• 1. Costa J
  2. Lopes CM
  3. Barsheshet A
  4. Moss AJ
  5. Migdalovich D
  6. Ouellet G
  7. McNitt S
  8. Polonsky S
  9. Robinson JL
  10. Zareba W
  11. Ackerman MJ
  12. Benhorin J
  13. Kaufman ES
  14. Platonov PG
  15. Shimizu W
  16. Towbin JA
  17. Vincent GM
  18. Wilde AA
  19. Goldenberg I
  Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 9(6). 2012 Jun.
• 1. Barsheshet A
  2. Goldenberg I
  3. O-Uchi J
  4. Moss AJ
  5. Jons C
  6. Shimizu W
  7. Wilde AA
  8. McNitt S
  9. Peterson DR
  10. Zareba W
  11. Robinson JL
  12. Ackerman MJ
  13. Cypress M
  14. Gray DA
  15. Hofman N
  16. Kanters JK
  17. Kaufman ES
  18. Platonov PG
  19. Qi M
  20. Towbin JA
  21. Vincent GM
  22. Lopes CM
  Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.; Circulation; Vol 125(16). 2012 Apr 24.
• 1. Couderc JP
  2. Xia X
  3. Denjoy I
  4. Extramiana F
  5. Maison-Blanche P
  6. Moss AJ
  7. Zareba W
  8. Lopes CM
  Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT Syndrome.; Journal of the American Heart Association; Vol 1(2). 2012 Apr.
• 1. Jhun BS
  2. O-Uchi J
  3. Wang W
  4. Ha CH
  5. Zhao J
  6. Kim JY
  7. Wong C
  8. Dirksen RT
  9. Lopes CM
  10. Jin ZG
  Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.; Circulation research; Vol 110(1). 2012 Jan 6.
• 1. Goldenberg I
  2. Thottathil P
  3. Lopes CM
  4. Moss AJ
  5. McNitt S
  6. O-Uchi J
  7. Robinson JL
  8. Zareba W
  9. Ackerman MJ
  10. Kaufman ES
  11. Towbin JA
  12. Vincent M
  13. Barsheshet A
  Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 9(1). 2012 Jan.
• 1. Migdalovich D
  2. Moss AJ
  3. Lopes CM
  4. Costa J
  5. Ouellet G
  6. Barsheshet A
  7. McNitt S
  8. Polonsky S
  9. Robinson JL
  10. Zareba W
  11. Ackerman MJ
  12. Benhorin J
  13. Kaufman ES
  14. Platonov PG
  15. Shimizu W
  16. Towbin JA
  17. Vincent GM
  18. Wilde AA
  19. Goldenberg I
  Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 8(10). 2011 Oct.
• 1. Barsheshet A
  2. Moss AJ
  3. McNitt S
  4. Polonsky S
  5. Lopes CM
  6. Zareba W
  7. Robinson JL
  8. Ackerman MJ
  9. Benhorin J
  10. Kaufman ES
  11. Towbin JA
  12. Vincent GM
  13. Qi M
  14. Goldenberg I
  Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation.; Circulation. Cardiovascular genetics; Vol 4(5). 2011 Oct.
• 1. Jons C
  2. O-Uchi J
  3. Moss AJ
  4. Reumann M
  5. Rice JJ
  6. Goldenberg I
  7. Zareba W
  8. Wilde AA
  9. Shimizu W
  10. Kanters JK
  11. McNitt S
  12. Hofman N
  13. Robinson JL
  14. Lopes CM
  Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.; Science translational medicine; Vol 3(76). 2011 Mar 30.
• 1. Horr S
  2. Goldenberg I
  3. Moss AJ
  4. O-Uchi J
  5. Barsheshet A
  6. Connelly H
  7. Gray DA
  8. Zareba W
  9. Lopes CM
  Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation.; Journal of cardiovascular electrophysiology; Vol 22(2). 2011 Feb.
• 1. Goldenberg I
  2. Horr S
  3. Moss AJ
  4. Lopes CM
  5. Barsheshet A
  6. McNitt S
  7. Zareba W
  8. Andrews ML
  9. Robinson JL
  10. Locati EH
  11. Ackerman MJ
  12. Benhorin J
  13. Kaufman ES
  14. Napolitano C
  15. Platonov PG
  16. Priori SG
  17. Qi M
  18. Schwartz PJ
  19. Shimizu W
  20. Towbin JA
  21. Vincent GM
  22. Wilde AA
  23. Zhang L
  Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.; Journal of the American College of Cardiology; Vol 57(1). 2011 Jan 4.
• 1. Williams DM
  2. Lopes CM
  3. Rosenhouse-Dantsker A
  4. Connelly HL
  5. Matavel A
  6. O-Uchi J
  7. McBeath E
  8. Gray DA
  Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.; Journal of the American Society of Nephrology : JASN; Vol 21(12). 2010 Dec.
• 1. Kim JA
  2. Lopes CM
  3. Moss AJ
  4. McNitt S
  5. Barsheshet A
  6. Robinson JL
  7. Zareba W
  8. Ackerman MJ
  9. Kaufman ES
  10. Towbin JA
  11. Vincent M
  12. Goldenberg I
  Trigger-specific risk factors and response to therapy in long QT syndrome type 2.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 7(12). 2010 Dec.
• 1. O-Uchi J
  2. Lopes CM
  Combined blockade of β- and α₁-adrenoceptors in left ventricular remodeling induced by hypertension: beneficial or not?; Hypertension research : official journal of the Japanese Society of Hypertension; Vol 33(10). 2010 Oct.
• 1. Couderc JP
  2. Lopes CM
  Short and long QT syndromes: does QT length really matter?; Journal of electrocardiology; Vol 43(5). 2010 Sep.
• 1. Casey LM
  2. Pistner AR
  3. Belmonte SL
  4. Migdalovich D
  5. Stolpnik O
  6. Nwakanma FE
  7. Vorobiof G
  8. Dunaevsky O
  9. Matavel A
  10. Lopes CM
  11. Smrcka AV
  12. Blaxall BC
  Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.; Circulation research; Vol 107(4). 2010 Aug 20.
• 1. Wojtovich AP
  2. Williams DM
  3. Karcz MK
  4. Lopes CM
  5. Gray DA
  6. Nehrke KW
  7. Brookes PS
  A novel mitochondrial K(ATP) channel assay.; Circulation research; Vol 106(7). 2010 Apr 16.
• 1. Matavel A
  2. Medei E
  3. Lopes CM
  PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions.; Channels (Austin, Tex.); Vol 4(1). 2010 Jan.
• 1. Jons C
  2. Moss AJ
  3. Lopes CM
  4. McNitt S
  5. Zareba W
  6. Goldenberg I
  7. Qi M
  8. Wilde AA
  9. Shimizu W
  10. Kanters JK
  11. Towbin JA
  12. Ackerman MJ
  13. Robinson JL
  Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome.; Journal of cardiovascular electrophysiology; Vol 20(8). 2009 Aug.
• 1. Matavel A
  2. Lopes CM
  PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.; Journal of molecular and cellular cardiology; Vol 46(5). 2009 May.
• 1. Lopes CM
  2. Remon JI
  3. Matavel A
  4. Sui JL
  5. Keselman I
  6. Medei E
  7. Shen Y
  8. Rosenhouse-Dantsker A
  9. Rohacs T
  10. Logothetis DE
  Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.; Channels (Austin, Tex.); Vol 1(2). 2007 Mar.
• 1. Rohács T
  2. Lopes CM
  3. Michailidis I
  4. Logothetis DE
  PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.; Nature neuroscience; Vol 8(5). 2005 May.
• 1. Lopes CM
  2. Rohács T
  3. Czirják G
  4. Balla T
  5. Enyedi P
  6. Logothetis DE
  PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.; The Journal of physiology; Vol 564(Pt 1). 2005 Apr 1.
• 1. Du X
  2. Zhang H
  3. Lopes C
  4. Mirshahi T
  5. Rohacs T
  6. Logothetis DE
  Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.; The Journal of biological chemistry; Vol 279(36). 2004 Sep 3.
• 1. Meyers MB
  2. Fischer A
  3. Sun YJ
  4. Lopes CM
  5. Rohacs T
  6. Nakamura TY
  7. Zhou YY
  8. Lee PC
  9. Altschuld RA
  10. McCune SA
  11. Coetzee WA
  12. Fishman GI
  Sorcin regulates excitation-contraction coupling in the heart.; The Journal of biological chemistry; Vol 278(31). 2003 Aug 1.
• 1. Zhang H
  2. Craciun LC
  3. Mirshahi T
  4. Rohács T
  5. Lopes CM
  6. Jin T
  7. Logothetis DE
  PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.; Neuron; Vol 37(6). 2003 Mar 27.
• 1. Rohács T
  2. Lopes CM
  3. Jin T
  4. Ramdya PP
  5. Molnár Z
  6. Logothetis DE
  Specificity of activation by phosphoinositides determines lipid regulation of Kir channels.; Proceedings of the National Academy of Sciences of the United States of America; Vol 100(2). 2003 Jan 21.
• 1. Lopes CM
  2. Zhang H
  3. Rohacs T
  4. Jin T
  5. Yang J
  6. Logothetis DE
  Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.; Neuron; Vol 34(6). 2002 Jun 13.
• 1. Rohács T
  2. Lopes C
  3. Mirshahi T
  4. Jin T
  5. Zhang H
  6. Logothetis DE
  Assaying phosphatidylinositol bisphosphate regulation of potassium channels.; Methods in enzymology; Vol 345. 2002.
• 1. Lopes CM
  2. Zilberberg N
  3. Goldstein SA
  Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.; The Journal of biological chemistry; Vol 276(27). 2001 Jul 6.
• 1. Lopes CM
  2. Gallagher PG
  3. Buck ME
  4. Butler MH
  5. Goldstein SA
  Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.; The Journal of biological chemistry; Vol 275(22). 2000 Jun 2.
• 1. Lopes CM
  2. Franks NP
  3. Lieb WR
  Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones.; British journal of pharmacology; Vol 125(2). 1998 Sep.
• 1. Lopes CM
  2. Louro SR
  The effects of n-alkanols on the lipid/protein interface of Ca(2+)-ATPase of sarcoplasmic reticulum vesicles.; Biochimica et biophysica acta; Vol 1070(2). 1991 Dec 9.
• 1. Wajnberg E
  2. Tabak M
  3. Nussenzveig PA
  4. Lopes CM
  5. Louro SR
  pH-dependent phase transition of chlorpromazine micellar solutions in the physiological range.; Biochimica et biophysica acta; Vol 944(2). 1988 Oct 6.