URMC / Cardiovascular Research Institute / Research / Lopes Lab / Publications Recent Publications Braun CParks XXQudsi HLopes CM PKCβII specifically regulates KCNQ1/KCNE1 channel membrane localization.; Journal of molecular and cellular cardiology; Vol 138. 2020 Jan. Ronzier EParks XXQudsi HLopes CM Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization.; Scientific reports; Vol 9(1). 2019 Nov 28. Parks XXRonzier EO-Uchi JLopes CM Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca2+-dependent PKC activation.; Journal of molecular and cellular cardiology; Vol 129. 2019 Apr. Bookstaver PBJenkins TCStenehjem EDoron SBrown JGoldwater SHLopes CHaynes AUdeze CMo YGillard PLiu YKeyloun K Impact of Outpatient vs Inpatient ABSSSI Treatment on Outcomes: A Retrospective Observational Analysis of Medical Charts Across US Emergency Departments.; Open forum infectious diseases; Vol 5(7). 2018 Jul. Kutyifa VDaimee UMcNitt SPolonsky BLowenstein CCutter KLopes CZareba WMoss AJ Clinical aspects of the three major genetic forms of long QT syndrome (LQT1, LQT2, LQT3).; Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2018 Mar 05. Roberts JDKrahn ADAckerman MJRohatgi RKMoss AJNazer BTadros RGerull BSanatani SWijeyeratne YDBaruteau AEMuir ARPang BCadrin-Tourigny JTalajic MRivard LTester DJLiu TWhitman IRWojciak JConacher SGula LJLeong-Sit PManlucu JGreen MSHamilton RHealey JSLopes CMBehr ERWilde AAGollob MHScheinman MM Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?; Circulation. Arrhythmia and electrophysiology; Vol 10(8). 2017 Aug. Wilde AAMoss AJKaufman ESShimizu WPeterson DRBenhorin JLopes CTowbin JASpazzolini CCrotti LZareba WGoldenberg IKanters JKRobinson JLQi MHofman NTester DJBezzina CRAlders MAiba TKamakura SMiyamoto YAndrews MLMcNitt SPolonsky BSchwartz PJAckerman MJ Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.; Circulation; Vol 134(12). 2016 Sep 20. Ruwald MHXu Parks XMoss AJZareba WBaman JMcNitt SKanters JKShimizu WWilde AAJons CLopes CM Stop-codon and C-terminal nonsense mutations are associated with a lower risk of cardiac events in patients with long QT syndrome type 1.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 13(1). 2016 Jan. O-Uchi JSorenson JJhun BSMishra JHurst SWilliams KSheu SSLopes CM Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.; Biochemical and biophysical research communications; Vol 465(3). 2015 Sep 25. O-Uchi JRice JJRuwald MHParks XXRonzier EMoss AJZareba WLopes CM Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.; Journal of molecular and cellular cardiology; Vol 79. 2015 Feb. Mathias AMoss AJLopes CMBarsheshet AMcNitt SZareba WRobinson JLLocati EHAckerman MJBenhorin JKaufman ESPlatonov PGQi MShimizu WTowbin JAMichael Vincent GWilde AAZhang LGoldenberg I Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 10(5). 2013 May. Mullally JGoldenberg IMoss AJLopes CMAckerman MJZareba WMcNitt SRobinson JLBenhorin JKaufman ESTowbin JABarsheshet A Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 10(3). 2013 Mar. Hoefen RReumann MGoldenberg IMoss AJO-Uchi JGu YMcNitt SZareba WJons CKanters JKPlatonov PGShimizu WWilde AARice JJLopes CM In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models.; Journal of the American College of Cardiology; Vol 60(21). 2012 Nov 20. Costa JLopes CMBarsheshet AMoss AJMigdalovich DOuellet GMcNitt SPolonsky SRobinson JLZareba WAckerman MJBenhorin JKaufman ESPlatonov PGShimizu WTowbin JAVincent GMWilde AAGoldenberg I Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 9(6). 2012 Jun. Barsheshet AGoldenberg IO-Uchi JMoss AJJons CShimizu WWilde AAMcNitt SPeterson DRZareba WRobinson JLAckerman MJCypress MGray DAHofman NKanters JKKaufman ESPlatonov PGQi MTowbin JAVincent GMLopes CM Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.; Circulation; Vol 125(16). 2012 Apr 24. Couderc JPXia XDenjoy IExtramiana FMaison-Blanche PMoss AJZareba WLopes CM Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT Syndrome.; Journal of the American Heart Association; Vol 1(2). 2012 Apr. Jhun BSO-Uchi JWang WHa CHZhao JKim JYWong CDirksen RTLopes CMJin ZG Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.; Circulation research; Vol 110(1). 2012 Jan 6. Goldenberg IThottathil PLopes CMMoss AJMcNitt SO-Uchi JRobinson JLZareba WAckerman MJKaufman ESTowbin JAVincent MBarsheshet A Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 9(1). 2012 Jan. Migdalovich DMoss AJLopes CMCosta JOuellet GBarsheshet AMcNitt SPolonsky SRobinson JLZareba WAckerman MJBenhorin JKaufman ESPlatonov PGShimizu WTowbin JAVincent GMWilde AAGoldenberg I Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 8(10). 2011 Oct. Barsheshet AMoss AJMcNitt SPolonsky SLopes CMZareba WRobinson JLAckerman MJBenhorin JKaufman ESTowbin JAVincent GMQi MGoldenberg I Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation.; Circulation. Cardiovascular genetics; Vol 4(5). 2011 Oct. Jons CO-Uchi JMoss AJReumann MRice JJGoldenberg IZareba WWilde AAShimizu WKanters JKMcNitt SHofman NRobinson JLLopes CM Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.; Science translational medicine; Vol 3(76). 2011 Mar 30. Horr SGoldenberg IMoss AJO-Uchi JBarsheshet AConnelly HGray DAZareba WLopes CM Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation.; Journal of cardiovascular electrophysiology; Vol 22(2). 2011 Feb. Goldenberg IHorr SMoss AJLopes CMBarsheshet AMcNitt SZareba WAndrews MLRobinson JLLocati EHAckerman MJBenhorin JKaufman ESNapolitano CPlatonov PGPriori SGQi MSchwartz PJShimizu WTowbin JAVincent GMWilde AAZhang L Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.; Journal of the American College of Cardiology; Vol 57(1). 2011 Jan 4. Williams DMLopes CMRosenhouse-Dantsker AConnelly HLMatavel AO-Uchi JMcBeath EGray DA Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.; Journal of the American Society of Nephrology : JASN; Vol 21(12). 2010 Dec. Kim JALopes CMMoss AJMcNitt SBarsheshet ARobinson JLZareba WAckerman MJKaufman ESTowbin JAVincent MGoldenberg I Trigger-specific risk factors and response to therapy in long QT syndrome type 2.; Heart rhythm : the official journal of the Heart Rhythm Society; Vol 7(12). 2010 Dec. O-Uchi JLopes CM Combined blockade of β- and α₁-adrenoceptors in left ventricular remodeling induced by hypertension: beneficial or not?; Hypertension research : official journal of the Japanese Society of Hypertension; Vol 33(10). 2010 Oct. Couderc JPLopes CM Short and long QT syndromes: does QT length really matter?; Journal of electrocardiology; Vol 43(5). 2010 Sep. Casey LMPistner ARBelmonte SLMigdalovich DStolpnik ONwakanma FEVorobiof GDunaevsky OMatavel ALopes CMSmrcka AVBlaxall BC Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.; Circulation research; Vol 107(4). 2010 Aug 20. Wojtovich APWilliams DMKarcz MKLopes CMGray DANehrke KWBrookes PS A novel mitochondrial K(ATP) channel assay.; Circulation research; Vol 106(7). 2010 Apr 16. Matavel AMedei ELopes CM PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions.; Channels (Austin, Tex.); Vol 4(1). 2010 Jan. Jons CMoss AJLopes CMMcNitt SZareba WGoldenberg IQi MWilde AAShimizu WKanters JKTowbin JAAckerman MJRobinson JL Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome.; Journal of cardiovascular electrophysiology; Vol 20(8). 2009 Aug. Matavel ALopes CM PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.; Journal of molecular and cellular cardiology; Vol 46(5). 2009 May. Lopes CMRemon JIMatavel ASui JLKeselman IMedei EShen YRosenhouse-Dantsker ARohacs TLogothetis DE Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.; Channels (Austin, Tex.); Vol 1(2). 2007 Mar. Rohács TLopes CMMichailidis ILogothetis DE PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.; Nature neuroscience; Vol 8(5). 2005 May. Lopes CMRohács TCzirják GBalla TEnyedi PLogothetis DE PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.; The Journal of physiology; Vol 564(Pt 1). 2005 Apr 1. Du XZhang HLopes CMirshahi TRohacs TLogothetis DE Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.; The Journal of biological chemistry; Vol 279(36). 2004 Sep 3. Meyers MBFischer ASun YJLopes CMRohacs TNakamura TYZhou YYLee PCAltschuld RAMcCune SACoetzee WAFishman GI Sorcin regulates excitation-contraction coupling in the heart.; The Journal of biological chemistry; Vol 278(31). 2003 Aug 1. Zhang HCraciun LCMirshahi TRohács TLopes CMJin TLogothetis DE PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.; Neuron; Vol 37(6). 2003 Mar 27. Rohács TLopes CMJin TRamdya PPMolnár ZLogothetis DE Specificity of activation by phosphoinositides determines lipid regulation of Kir channels.; Proceedings of the National Academy of Sciences of the United States of America; Vol 100(2). 2003 Jan 21. Lopes CMZhang HRohacs TJin TYang JLogothetis DE Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.; Neuron; Vol 34(6). 2002 Jun 13. Rohács TLopes CMirshahi TJin TZhang HLogothetis DE Assaying phosphatidylinositol bisphosphate regulation of potassium channels.; Methods in enzymology; Vol 345. 2002. Lopes CMZilberberg NGoldstein SA Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.; The Journal of biological chemistry; Vol 276(27). 2001 Jul 6. Lopes CMGallagher PGBuck MEButler MHGoldstein SA Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.; The Journal of biological chemistry; Vol 275(22). 2000 Jun 2. Lopes CMFranks NPLieb WR Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones.; British journal of pharmacology; Vol 125(2). 1998 Sep. Lopes CMLouro SR The effects of n-alkanols on the lipid/protein interface of Ca(2+)-ATPase of sarcoplasmic reticulum vesicles.; Biochimica et biophysica acta; Vol 1070(2). 1991 Dec 9. Wajnberg ETabak MNussenzveig PALopes CMLouro SR pH-dependent phase transition of chlorpromazine micellar solutions in the physiological range.; Biochimica et biophysica acta; Vol 944(2). 1988 Oct 6.