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Lowenstein Lab

Charles J. Lowenstein, M.D.

Chief, Department of Medicine, Cardiology
Director - Aab Cardiovascular Research Institute
Paul N. Yu Professorship in Cardiology - Department of Medicine, Cardiology
Professor - Department of Medicine, Cardiology
1986 | M.D. | Medicine | Harvard Medical School
1982 | B.S. | Biochemistry | Harvard University

Research Overview

The Lowenstein Lab studies vascular inflammation. Specific current projects include: regulation of nitric oxide signaling, endothelial exocytosis of inflammatory granules, microRNA regulation of hypoxic signaling. Our scientific approach is through molecular biology, in vitro cell culture, and relevant mouse genetic models. We employ in vivo models to study tumor angiogenesis, leukocyte trafficking, and thrombosis.



Endothelial Exocytosis

TRX Restores

Nitric Oxide Signaling


MicroRNA Regulation of Hypoxic Signaling

Recent Publications

  1. Zhu Q… and Lowenstein CJ, Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):264-270.
  2. Miano J… and Lowenstein CJ, A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research., Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1058-75.
  3. Cameron S… and Lowenstein CJ, A Novel Anti-Inflammatory Effect for High Density Lipoprotein., PLoS One. 2015 Dec 17;10(12):e0144372.
  4. Zhu Q… and Lowenstein CJ, SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor., PLoS One. 2015 Aug 12;10(8):e0118737.
  5. Ito T… and Lowenstein CJThioredoxin increases exocytosis by denitrosylating N-ethylmaleimide sensitive factor. J Biol Chem. 2011 Apr 1;286(13):11179-84
  6. Yamakuchi M… and Lowenstein CJ. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-9.
  7. Jeong Y… and Lowenstein CJ.  Aldosterone activates endothelial exocytosis.  Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3782-7.
  8. Cao W…. and Lowenstein CJAcetylation of MAP Kinase Phosphatase-1 Inhibits Toll-Like Receptor SignalingJ. Exp. Med. 2008 Jun 9;205(6):1491-50
  9. Morrell CN… and Lowenstein CJGlutamate Mediates Platelet Activation Through the AMPA Receptor. J. Exp. Med. 2008 Mar 17;205(3):575-84.
  10. Harris T…. and Lowenstein CJMicroRNA-126 Regulates Endothelial Expression of Vascular Cell Adhesion Molecule-1Proc. Natl. Acad. Sci U.S.A. 2008 Feb 5;105(5):1516-21.
  11. Matsushita K…. and Lowenstein CJ. Nitric Oxide Regulation of Exocytosis by S-Nitrosylation of N-ethylmaleimide Sensitive Factor.  Cell  2003 Oct 17; 115(2): 139-150.

More papers:PubMed

Graduate Program Affiliations

HHMI Med-into-Grad Program