Charles J. Lowenstein, M.D.
Chief, Department of Medicine, Cardiology
Director - Aab Cardiovascular Research Institute
Paul N. Yu Professorship in Cardiology - Department of Medicine, Cardiology
Professor - Department of Medicine, Cardiology
1986 | M.D. | Medicine | Harvard Medical School
1982 | B.S. | Biochemistry | Harvard University
The Lowenstein Lab studies vascular inflammation. Specific current projects include: regulation of nitric oxide signaling, endothelial exocytosis of inflammatory granules, microRNA regulation of hypoxic signaling. Our scientific approach is through molecular biology, in vitro cell culture, and relevant mouse genetic models. We employ in vivo models to study tumor angiogenesis, leukocyte trafficking, and thrombosis.
Nitric Oxide Signaling
MicroRNA Regulation of Hypoxic Signaling
Matsushita K….and Lowenstein CJ. Nitric Oxide Regulation of Exocytosis by S-Nitrosylation of N-ethylmaleimide Sensitive Factor. Cell 2003 Oct 17; 115(2): 139-150.
Harris T…. and Lowenstein CJ. MicroRNA-126 Regulates Endothelial Expression of Vascular Cell Adhesion Molecule-1. Proc. Natl. Acad. Sci U.S.A. 2008 Feb 5;105(5):1516-21.
Morrell CN… and Lowenstein CJ. Glutamate Mediates Platelet Activation Through the AMPA Receptor. J. Exp. Med. 2008 Mar 17;205(3):575-84.
Cao W…. and Lowenstein CJ. Acetylation of MAP Kinase Phosphatase-1 Inhibits Toll-Like Receptor Signaling. J. Exp. Med. 2008 Jun 9;205(6):1491-50
Jeong Y… and Lowenstein CJ. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3782-7.
Yamakuchi M … and Lowenstein CJ. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6334-9.
Ito T, Yamakuchi M, Lowenstein CJ. Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide sensitive factor. J Biol Chem. 2011 Apr 1;286(13):11179-84
Graduate Program Affiliations
HHMI Med-into-Grad Program