microRNA and Hypoxia
MicroRNA are short non-coding RNA species that regulate mRNA translation. Hypoxia induces a set of microRNA that regulate the expression of proteins involved in angiogenesis and metabolism. We have identified targets of microRNA that regulate hypoxia pathways. For example, miR-107 controls expression of hypoxia-inducible factor -1ß (HIF-1ß) and modulates tumor angiogenesis. Current projects are studying microRNA expressed in endothelial cells that regulate metabolism, and microRNA in cancer cells that regulate proliferation.