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Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W. "Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration." PLoS Genetics. 2014 Oct; 10(10):e1004579. Epub 2014 Oct 09. PDF

Zhu XJ, Liu Y, Dai ZM, Zhang X, Yang X, Li Y, Qiu M, Fu J, Hsu W, Chen Y, Zhang Z. "BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin." PLoS Genetics. 2014 Oct; 10(10):e1004687. Epub 2014 Oct 16. PDF

Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. "CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors." Cancer Research. 2014 Oct 1; 74(19):5480-92. Epub 2014 Aug 11. PDF

McGee-Lawrence ME, Carpio LR, Bradley EW, Dudakovic A, Lian JB, van Wijnen AJ, Kakar S, Hsu W, Westendorf JJ. "Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice." Bone. 2014 Sep; 66:277-86. Epub 2014 Jun 25. PDF

Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ. "BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway." Osteoarthritis and Cartilage. 2014 Mar; 22(3):481-9. Epub 2014 Jan 11. PDF

Ming Jiang, Wei-Yao Ku, Jiang Fu, Guy, Wei Hsu and Jianwen Que (2013). Gpr177 regulates pulmonary vasculature development. Development, 140, 3589-3594. PMID: 23884445, PMCID: In Progress.  PDF

Xiaojing Zhu, Pan Zhao, Yudong Liu, Xiaoyun Zhang, Jiang Fu, H-M Ivy Yu, Mengsheng Qiu, Yiping Chen, Wei Hsu and Zunyi Zhang (2013). Intra-epithelial canonical Wnt ligands are required for normal tooth development. Journal of Biological Chemistry, Epub: March 24, 2013. PDF

Eri O Maruyama, H-M Ivy Yu, Ming Jiang, Jiang Fu and Wei Hsu (2013). Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis. PLoS One, 8(2): e56644. PDF

Meghan E McGee-Lawrence, Xiaodong Li, Aditi B Kantipuly, David F Razidlo, Bridget A Stensgard, Gary S Stein, Jane B Lian, Wei Hsu and Jennifer J Westendorf (2013). Runx2 regulates Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-defient mice. Journal of Biological Chemistry, 288, 5291-5302.PDF

Jiang Fu and Wei Hsu (2013). Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. Journal of Investigative Dermatology, 133, 890-898 (Epub November 29, 2012).PDF

Takamitsu Maruyama, Ming Jiang and Wei Hsu (2013). Gpr177, a novel locus for bone-mineral-density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.Journal of Bone and Mineral Research,28, 1150-9, Epub Nov 27, 2012. PDF

Chad A Galloway, Hakjoo Lee, Souad Nejjar, Bong Sook Jhun, Tianzheng Yu, Wei Hsu and Yisang Yoon (2012). Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress. Diabetes, 61, 2093-2104. PDF

Yong-guo Zhang, Shaoping Wu, Yinglin Xia, Di Chen, Elaine O Petrof, Erika C Claud, Wei Hsu and Jun Sun (2012). Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells. PLoS One, 7(4): e34942. PDF

Debbie Y Dao, Jennifer H Jonason, Yongchun Zhang, Wei Hsu, Di Chen, Mathew J Hilton and Regis J O'Keefe (2012). Cartilage-specific b-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. Journal of Bone and Mineral Research, 27, 1680-1694. PDF

Congxing Lin, Alexander V Fisher, Yan Yin, Takamitsu Maruyama, George M Veith, Maulik Dhandha, Genkai J Huang, Wei Hsu and Liang Ma. The inductive role of Wnt-b-catenin signaling in the formation of oral apparatus (2011). Developmental Biology, 356, 40-50. PDF

Ming Jiang, Shang-Yi Chiu and Wei Hsu. SUMO-specific protease 2 in Mdm2-mediated regulation of p53 (2011). Cell Death and Differentiation, 18, 1005-1015. PDF

Jiang Fu, H-M Ivy Yu, Takamitsu Maruyama, Anthony J Mirando and Wei Hsu (2011). Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Developmental Dynamics, 240, 365-371. PDF

Anthony J Mirando, Takamitsu Maruyama, Jiang Fu, H-M Ivy Yu and Wei Hsu (2010). Beta-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Developmental Biology, 10: 116. Webpage

Cover, Science Signaling

Takamitsu Maruyama, Anthony J Mirando, Chu-Xia Deng and Wei Hsu (2010). The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Science Signaling, 3, ra40. PDF

H-M Ivy Yu, Ying Jin, Jiang Fuand Wei Hsu. Expression of Gpr177, a Wnt trafficking regulator in mouse embryogenesis (2010). Developmental Dynamics, 239, 2101-2109. PDF

Shang-Yi Chiu, Eri O Maruyama and Wei Hsu (2010). Derivation of mouse trophoblast stem cells from blastocysts. Journal of Visualized Experiments. 40., DOI: 10.3791/1964. PDF, See Video Article

Jiang Fu, Ming Jiang, Anthony J Mirando, H-M Ivy Yu and Wei Hsu (2009). Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci USA, 106, 18598-18603. PDF

Wei Hsu, Anthony J Mirando and H-M Ivy Yu. Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural creast cells (2010). Developmental Dynamics: a special issue for Wnt signaling in development and disease, 239, 338-345. Published Online: Aug 3, 2009. PDF

Ying Yan, Dezhi Tang, Mo Chen, Jian Huang, Jennifer H Jonason, Xiaohong Tan, David Reynolds, Wei Hsu, Stephen E Harris, J Edward Puzas, Hani Award, Regis J O'Keefe, Brendan F Boyce and Di Chen (2009). Axin2 controls bone remodeling through b-catenin-BMP signaling pathway in adult mice. Journal of Cell Science, 122, 3566-3578. PDF

Sui Wang, Jan N Jensen, Philip A Seymour, Wei Hsu, Yuval Dor, Maike Sander, Mark A Magnuson, Palle Serup and Guoqiang Gu (2009). Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci USA, 106, 9715-9720. PDF

Shang-Yi Chiu, Naoya Asai, Frank Costantini and Wei Hsu (2008). SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biology, 6(12): e310. PDF (Editor's Pick of the Week). Commentary in PLoS Biology: Sedwick C. Lessons on Life from SENP2 (2008). PLoS Biology, 6(12): e312. PDF

Bo Liu, H-M Ivy Yu, Jiaoti Huang and Wei Hsu (2008). Co-opted JNK/SAPK signaling in Wnt/b-catenin-induced tumorigenesis. Neoplasia, 10, 1004-1013. PDF

Bo Liu, H-M Ivy Yu and Wei Hsu (2007). Craniosynostosis caused by Axin2 deficiency is mediated through distinct functions of b-catenin in proliferation and differentiation. Developmental Biology, 301, 298-308. PDF

H-M Ivy Yu, Bo Liu, Frank Costantini and Wei Hsu (2007). Impaired neural development caused by inducible expression of Axin in transgenic mice. Mechanisms of Development, 124, 146-156. PDF

H-M Ivy Yu, Bo Liu, Shang-Yi Chiu, Frank Costantini and Wei Hsu (2005). Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci USA, 102, 8615-8620. PDF

H-M Ivy Yu, Boris Jerchow, Tzong-Jen Sheu, Bo Liu, Frank Costantini, J Edward Puzas, Walter Birchmeier and Wei Hsu (2005). The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development, 132, 1995-2005. PDF

Wei Hsu, Reena Shakya and Frank Costantini (2001). Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice. Journal of Cell Biology, 155, 1055-1064. PDF

MA Julius, B Schelbert, Wei Hsu, E Fitzpatrick, E Jho, F Fagotto, F Costantini and J Kitajewski (2000). Domains of axin and disheveled required for interaction and function in wnt signaling. Biochem Biophys Res Commun, 276, 1162-1169.

Wei Hsu, Li Zeng and Frank Costantini. Identification of a domain of Axin that binds to the Serine/Threonine Protein Phosphatase 2A and a self-binding domain (1999). Journal of Biological Chemistry, 274, 3439-3445. PDF

Li Zeng, Francois Fagotto, Tong Zhang, Wei Hsu, Thomas J. Vasicek, William L. Perry III, James J. Lee, Shirley M. Tilghman, Barry M. Gumbiner and Frank Costantini (1997). The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.Cell, 90, 181-192.

Lydija Klampfer, Tae Ho Lee, Wei Hsu, Jan Vilcék and Selina Chen-Kiang (1994). NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Molecular and Cellular Biology, 14, 6561-6569.

Wei Hsu, Tom K. Kerppola, Phang-Lang Chen, Tom Curran, and Selina Chen-Kiang (1994). Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Molecular and Cellular Biology, 14, 268-276.

Wei Hsu and Selina Chen-Kiang (1993). Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid in embryonal carcinoma cells. Molecular and Cellular Biology, 13, 2515-2523.

Selina Chen-Kiang, Wei Hsu, Yasodha Natkunam, and Xiaokui Zhang (1993). Nuclear signaling by IL-6. Current Opinion in Immunology, 5, 124-128.

Jonathan M. Spergel, Wei Hsu, Shizuo Akira, Bayar Thimmapaya, Tadamitsu Kishimoto, and Selina Chen-Kiang (1992). NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J. Virol., 66, 1021-1030.