Latest Grants & Awards
Robert Quivey, Ph.D.
Welcher Professor in Dental Research in the Center for Oral Biology
Director, Center for Oral Biology
Training Program in Oral Science- T90/R90
The major goal of this training program is train oral scientists, citizens (T90) and non-citizens (R90), to develop an interdisciplinary approach to study oral health related issues.
Tool Compounds to Probe Multispecies Biofilms in the Human Oral Microbiome (Subaward @ Emory University; Bill Wuest- PI)
Aims: 1. Identification of the biological target(s) of carolacton & CD1 using genetic and proteomic techniques. 2. Construction of a diversified library of tool compounds via diverted total synthesis 3. Evaluation of the biological activity of tool compounds by biochemical analysis, phenotypic screening, and multispecies assays.
NIH/ NIAID - 6/1/18-5/31/20
Role of Metal Transport in Streptococcus sanguinis Virulence and Competitiveness (Subaward @ Virginia Commonweath University; Todd Kitten- PI)
The goals of this project are to determine the mechanism by which a metal transporter contributes to endocarditis virulence in S. sanguinis, and to determine whether it also contributes to oral competitiveness.
Wei Hsu, Ph.D.
Dean's Professor of Biomedical Genetics in the Center for Oral Biology
NIH/ NIDCR- 6/1/18-5/31/23
Stem Cells for Craniofacial Bone Repair and Regeneration.
The objective of this proposal is to further elucidate the mechanism underlying skeletal repair and regeneration mediated by newly identified suture stem cells. Our goal is to explore their potential use for stem cell-based therapy and to advance our knowledge base of regenerative medicine.
NIH/ NIDCR- 2/12/19-1/31/24
Genetic Regulatory Network in Craniofacial Development
The objective of this competing renewal is to continue his efforts to decipher the skeletogenic signaling network underlying craniofacial development and disease.
Catherine Ovitt, Ph.D.
Associate Professor of Biomedical Genetics in the Center for Oral Biology
NIH/ NIDCR- 8/7/18-7/31/20
Single Chemosensory Cells in the Salivary Gland.
Aim 1: To establish that SCCs are active in the salivary glands; Aim 2: Investigate a role for SSCs in the SG immune response to Sjogren’s syndrome.
Engineered Salivary Gland Tissue Chips
Specific Aims include: UG3 Aim 1. Examine the dependence of cell seeding ratio (acinar to duct) and cell number on salivary gland organoid formation and function in MB well arrays. UG3 Aim 2. Examine the effect of hydrogel biochemical cues on cell self-assembly and secretory function of encapsulated salivary gland cells. UH3 Aim 3. Demonstrate the utility of salivary gland tissue chips by performing high-throughput library screen to discover radioprotective drugs and validate discovered entities using irradiated mice.