Latest Grants & Awards Wei Hsu, Ph.D. Professsor of Biomedical Genetics in the Center for Oral Biology Professor of Oncology in the Center for Oral Biology Stem Cell-mediated Craniofacial Skeletogenesis in Health and Disease 6/1/14-5/31/17 NYSTEM The objective of this proposal is to identify and characterize the stem cells responsible for calvarial morphogenesis in health and disease. Jose Lemos, Ph.D. (Co-PI) Associate Professor of Microbiology in the Center for Oral Biology Jacqueline Abranches, Ph.D. (Co-PI) Research Associate Professor of Microbiology in the Center for Oral Biology Intracellular Invasion by Streptococcus mutans: Significance in Disease 5/17/13-3/31/18 RO1 DE02255 The goals of this application are to conduct the functional analysis of the collagen-binding protein Cnm and to characterize the role of Cnm in host-bacteria interactions. To achieve these goals, we propose to use in vitro approaches to further characterize, genetically and biochemically, Cnm and its associated proteins, an ex vivo adhesion model to examine the role of Cnm in the colonization of heart tissues, and an in vivo rabbit endocarditis model to conclusively demonstrate the contribution of Cnm to the pathogenesis of infective endocarditis. Catherine Ovitt, Ph.D. Associate Professor of Biomedical Genetics in the Center for Oral Biology A Genetic Model for Salivary Gland Adenoid Cystic Carcinoma 7/1/14-6/30/15 Wilmot Cancer Center The major goal of this proposal is to develop a model that can be used for the molecular investigation of adenoid cystic carcinoma (ACC) of the salivary gland. The second-most common of all salivary gland malignancies, ACC is an aggressive cancer, with very poor prognosis.