March 30, 2015 ( Monday )


Grand Rounds
12:00pm
CANCELLED-Department of Biology Donut Talk

Dr. Celina Juliano, Yale University Stem Cell Center

"PIWI-piRNA pathway function in the stem cells of the "immortal" Hydra"

Location:  Lander Auditorium - Hutchison 140

Posted by:  Brenna Rybak, Biology, 16-Mar-15 9:32am ET


Research Meetings
12:00pm - 1:00pm
Department of Microbiology & Immunology Seminar Series

Jose R Conejo-Garcia, MD, PhD


Professor and Program Leader, Tumor Microenvironment and Metastasis Program, The Wistar Institute

" Microbial driven TLR5-dependent signaling governs distal malignant progression through systemic tumor-promoting inflammation "

Host: Edith Lord

Seminar Abstract: The dominant R392X TLR5 polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at (distal) extra-mucosal locations by promoting systemic IL-6 up-regulation, which drives MDSC mobilization. Mechanistically, expanded granulocytic MDSCs cause γδ lymphocytes in TLR5+/+ tumors to secrete galectin-1, dampening anti-tumor immunity and accelerating malignant progression. In contrast, IL-17 is consistently up-regulated in TLR5-unresponsive tumor-bearing individuals, but only accelerates malignant progression in IL-6-unresponsive tumors. Importantly, depletion of commensal bacteria abrogates any TLR5-dependent differences in tumor growth. Contrasting differences in inflammatory cytokines and malignant evolution are recapitulated in TLR5-responsive/unresponsive ovarian and breast cancer patients. Therefore, inflammation, anti-tumor immunity and the clinical outcome of cancer patients are influenced by a common TLR5 polymorphism.

http://www.wistar.org/our-science/scientists/jose-r-conejo-garcia-md-phd

Location:  Upper Auditorium, Rm 3-7619

Posted by:  Nicole Beaumont, Micro & Immunolgy, 2-Mar-15 10:53am ET


Other Events & Dates
4:00pm - 5:00pm
Physical Seminar - Chemistry

Speaker: Professor Chong Fang

Title: Elucidating Photochemical Reaction Pathways in Fluorescent Protein based Biosensors using Ultrafast Spectroscopy

Oregon State University, Department of Chemistry

Host: Professor David McCamant

Location:  Hutchison Hall 473

Posted by:  Marguerite Weston, Chemistry, 3-Feb-15 11:56am ET

 
 
http://www.urmc.rochester.edu/calendar/index.html