Second Cycle of Funding Requests for PCORI Open Now

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PCORI today launched its second cycle of funding requests to support $96 million in comparative clinical effectiveness research that will give patients and those who care for them the ability to make better-informed health care decisions. As with the first funding cycle, which opened in May, these PCORI Funding Announcements (PFAs) correspond to four of the five areas of focus outlined in its National Priorities for Research and Research Agenda:

  • Assessment of Prevention, Diagnosis, and Treatment Options - for projects that address critical decisions that patients, their caregivers and clinicians face with too little information.
  • Improving Healthcare Systems - for projects that address critical decisions that face health care systems, the patients and caregivers who rely on them, and the clinicians who work within them.
  • Communication and Dissemination - for projects that address critical elements in the communication and dissemination process among patients, their caregivers and clinicians.
  • Addressing Disparities - for projects that will inform the choice of strategies to eliminate disparities.

Additional PFAs, addressing PCORI's fifth priority, "Accelerating Patient-Centered and Methodological Research" will be issued beginning this fall. We encourage you to review our Funding Announcements and hope you consider submitting a Letter of Intent for Cycle II. All application materials can be accessed from the Funding Opportunities section of PCORI's website. Letters of Intent are due on October 15th.


The Patient-Centered Outcomes Research Institute (PCORI) is an independent, non-profit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers and clinicians with the evidence-based information needed to make better-informed health care decisions. PCORI is committed to continuously seeking input from a broad range of stakeholders to guide its work. More information is available at


NIH Funding Acknowledgement ** Important ** All publications resulting from the utilization of CTSI resources are required to credit the CTSI grant by including the NIH FUNDING ACKNOWLEDGEMENT and must comply with the NIH Public Access Policy.