Cancer Target Discovery and Development (CTDD) Network (U01)

The National Cancer Institute/NIH/DHHS has issued a Funding Opportunity Announcement (FOA) for the Cancer Target Discovery and Development (CTDD) initiative to promote innovative research on high throughput approaches to the discovery and characterization of new cancer targets and their modulators. Projects resulting from this FOA are expected to bridge the gap between the enormous volumes of data generated by the comprehensive molecular characterizations of many cancer subtypes and the ability to use these data for the development of human cancer therapeutics and associated response markers.

Applicants must propose research projects focused on high throughput identification and/or characterization of potential targets for cancer therapy, and/or the identification of small molecules that modulate validated cancer targets. Proposed projects are expected to combine in-depth mining of large-scale genomic data, systems biology analyses, and/or experimental approaches to provide initial characterization of functional significance. This characterization may involve the studies of modulation/perturbation of the potential targets (or target combinations) using, e.g., small molecules and/or oligonucleotides. Development and/or improvement of technologies serving the main goals of the project may also be proposed.

In addition to conducting individual research projects, the CTDD awardees will also be expected to contribute to trans-Network activities, including participation in joint pilot research projects.  Successful applicants will join the existing Network.

This is a limited submission program. The University may submit only two (2) proposals. Interested faculty members must submit an abstract, CV, and budget to Dean Puzas ( by April 20, using the words “Cancer Target Discovery” in the subject line. The Deans will select candidates by May 1.

The complete program solicitation can be found here. The deadline for the optional Letter of Intent is May 21. The full proposals are due June 21. 


NIH Funding Acknowledgement ** Important ** All publications resulting from the utilization of CTSI resources are required to credit the CTSI grant by including the NIH FUNDING ACKNOWLEDGEMENT and must comply with the NIH Public Access Policy.