Wednesday, September 28, 2016
A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body’s immune system. This University of Rochester Medical Center discovery could provide a new strategy for live influenza vaccines in the future.
A new approach to the live flu vaccine would be particularly advantageous right now after the Centers for Disease Control and Prevention stopped recommending use of the live attenuate flu vaccine, FluMist® earlier this year. Several studies found that the pain-free nasal spray, which was used in about one-third of young children in the U.S., offered no protection to that especially vulnerable population. The flu shot, on the other hand, performed well and the CDC recommends using this vaccine in place of FluMist®.
“There is a need to understand what's happening with the existing live vaccine and potentially a need to develop a new one,” said David Topham, Ph.D., Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Microbiology and Immunology at URMC and author of the study. “We proposed that the mutation we found could be used to create a live vaccine.”Read More: URMC Researchers Discover Rare Flu-Thwarting Mutation
Monday, June 27, 2016
Immunotherapy for cancer is an exciting topic, as it involves stimulating a patient’s own immune system to fight the malignancy. Although the concept has been around for 100 years,Wilmot scientists such as Minsoo Kim are making it more relevant today.
Kim is using a process called optogenetics to try to improve the response rates for immunotherapy, which range from about 30 percent to 70 percent. He wants to know why immunotherapy doesn’t work 100 percent of the time.
“It’s like we’re sending T-cells on a spy mission and guiding them throughout the process.”Read More: Minsoo Kim's Research Highlighted in 'Wilmot Stories'
Katie Richards Reaches 15 Years of Service at the University of Rochester
Tuesday, April 19, 2016
We would like to honor Katie Richards, a Technical Associate in the Sant Lab, for reaching 15 years of service at the University of Rochester.
"Katie has been invaluable to my laboratory’s success. She has contributed her expertise, diligence, and thoughtful approach to research towards the success of multiple projects in the laboratory. She has also been tremendously valuable to the laboratory for securing grant funding and publishing the results of our studies" ~ Andrea Sant.
Congratulations again to Katie and thank you for your continued service.
Tara Capece and Brandon Walling Receive Trainee Abstract Award
Wednesday, April 6, 2016
We are proud to recognize Tara Capece and Brandon Walling, who recently won the AAI Trainee Abstract Award www.aai.org/awards/Docs/Travel/2016_AAI_Trainee_Abstract_Award.pdf. This award provides travel support to AAI Trainee members (graduate students and postdoctoral fellows) whose first-author abstracts submitted to the AAI annual meeting are selected for oral presentation in Block symposia.
Tara and Brandon are part of Minsoo Kim's lab. The Kim lab focuses on understanding how lymphocytes home to and migrate within tissues, specifically studying the role of integrin LFA-1. Tara studies the function of LFA-1 in T cell activation and differentiation while Brandon's project aims to elucidate the LFA-1 mediated mechanism of chemokine independent migration.
Congratulations again to Tara and Brandon for their exciting science and gift to travel and present in the Block Symposium.