Zheng-Gen Jin, Ph.D.
Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute
|1991 | PhD | Physiology | China - Non-Medical School|
|1987 | BS | Physics | China - Non-Medical School|
Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.
The specific ongoing projects in the lab are:
- To characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect
- To identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction
- To define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines
- Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1., Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG., Circ Res. 2012 Jan 6;110(1):59-70. Epub 2011 Nov 10.
- Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.,
Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG.
Arterioscler Thromb Vasc Biol. 2011 May;31(5):1016-23. Epub 2011 Mar 3.
- PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy., Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG., Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15467-72. Epub 2010 Aug 17.
- Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS., Wang W, Ha CH, Jhun BS, Wong C, Jain MK, Jin ZG., Blood. 2010 Apr 8;115(14):2971-9. Epub 2009 Dec 30.
- Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells.
Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I.
Antioxid Redox Signal. 2010 Jun 15;12(12):1355-69.
Zheng-Gen Jin, Ph.D.
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box CVRI
Rochester, New York 14642
Jin Lab: (585) 276-7717