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31st Annual Genetics Day Symposium

Monday, April 22, 2019

The Departments of Biomedical Genetics and Biology, with the support of the University Committee for Interdisciplinary Studies, host the 31st annual Genetics Day Symposium on Thursday, April 25, from 9:30 a.m. to 4 p.m. in the Class of ’62 Auditorium and Flaum Atrium. This year’s Fred Sherman Lecturer will be Phillip Zamore, a Howard Hughes Medical Institute investigator and professor of biomedical sciences at the University of Massachusetts Medical School, giving a talk titled “piRNAs and the Struggle to Reproduce.”

Read More: 31st Annual Genetics Day Symposium

Latest Issue of Opportunities to explore - April 22-26, 2019

Monday, April 22, 2019

The new issue of opportunities to explore is out now!

Read The April 22-26, 2019 Issue

New Access Specialist

The Graduate Education & Postdoctoral Affairs Office is excited to introduce you to SMD’s new Access Specialist for graduate students and postdocs, Jen Prosceo. Jen joins us from MCC where she served as the Deaf/Hard of Hearing Specialist in MCC’s Disability Services Office. Prior to MCC, Jen worked as an ASL/English Interpreter in RIT’s Colleges of Liberal Arts and Imaging Arts and Sciences.

Students and postdocs may contact Jen directly to discuss/arrange for access services.

(585) 276-5075   |   jennifer.prosceo@rochester.edu

Handy Gelbard Honored for Pediatric HIV/AIDS Research

Wednesday, April 17, 2019

Harris Gelbard

Handy Gelbard, M.D., Ph.D., professor and director of the Center for Neurotherapeutics Discovery at URMC, is the 2019-2020 recipient of the Herman and Gertrude Silver Award, which honors individuals who have made significant contributions in the field of pediatric HIV and AIDS. The award is given by the Children’s Hospital of Philadelphia (CHOP) and the Department of Pediatrics of the Perelman School of Medicine at the University of Pennsylvania. Past award winners include a Nobel laureate and HIV investigators from leading academic institutions, the National Institutes of Health (including the current directors of the Office of AIDS Research and the National Institute of Allergy and Infectious Diseases), and the Centers for Disease Control and Prevention.

For the past 10 years Gelbard’s lab has been developing a compound called URMC-099, which dampens inflammation and has shown promise in reversing the neurological problems associated with HIV. Children with HIV who are taking combination antiretroviral therapies are extremely vulnerable to inflammation; the developing nervous system is of particular concern, as inflammation in the brain can lead to major cognitive problems.

The possibility of a new class of therapies that reduces the burden of neuroinflammation and supports normal synaptic architecture (the basis for learning and memory) offers considerable hope for children that are saddled with the unwanted burden of HIV, despite effective control of the virus.

Gelbard believes the path forward for URMC-099 as an adjunct agent for children living with HIV and neurologic disease will likely involve combination therapy with next generation antiretroviral agents. This is a priority in resource-limited settings such as Africa, and Gelbard is working with David Bearden, M.D., assistant professor in the division of Child Neurology at URMC to help advance uses for URMC-099 in pediatric patients there. Bearden’s work is supported by a National Institute of Neurological Disorders and Stroke grant to Gretchen Birbeck, M.D., M.P.H., professor of Neurology and Michael Potchen, M.D., professor of Imaging Sciences. The work is also supported by the University of Rochester Center for AIDS Research.

Gelbard will receive the Silver Award in November during a two-day symposium at CHOP. He will present pediatric grand rounds describing his progress in inventing the class of compounds spearheaded by URMC-099 and its role in treating pediatric and adult HIV infection and its complications. He’ll also give a seminar on current and future developments related to URMC-099 to attendees from multiple medical and scientific institutions in Philadelphia.

New Issue of Opportunities to Explore - April 15-19

Monday, April 15, 2019

The new issue of opportunities to explore is out now! Remember that next week is graduate student appreciation week

Read The April 15-19, 2019 Issue

Meet the Graduate Education & Postdoctoral Affairs Team

Benjamin Lovell

Benjamin Lovell, Admissions Coordinator and Assistant to the Dean

Ben serves as the Admissions Coordinator, managing the day-to-day admissions operations, and serving as assistant to the Senior Associate Dean for Graduate Education and Postdoctoral Affairs (SAD-GEPA). He also serves as Course Administrator for the “Ethics and Professional Integrity in Research” course, taught in the Fall semester.

Trainees typically contact Ben to discuss the graduate or preparatory program application process, to schedule a meeting with the SAD-GEPA, and for assistance with issues relating to the Ethics course. To request a meeting with Ben, please contact him directly at (585) 275-2933 or email Benjamin Lovell

TBS Student is Finalist in "Shark Tank"-Style Competition

Monday, April 15, 2019

Jesse WangCongratulations to Jesse Wang, a student in the UR CTSI Translational Biomedical Science Ph.D. program, who was one of four finalists in the ACP Innovation Challenge 2019. Wang presented his "digital scribe" technology at this “Shark Tank”-style competition hosted by the American College of Physicians, on Saturday, April 13. His digital scribe technology can capture statistical speech analysis and natural language conversation between a physician and patient and automatically update eRecord. The system would capture and document the appropriate information during a patient interview, alleviating physicians' workload.

URMC Trainee Travel Awards 2019

Monday, April 15, 2019

This award assists students and trainees at the University of Rochester School of Medicine and Dentistry to attend important national or international meetings at which they will present their research and make professional connections. Two awards of up to $1000 will be given this funding cycle: one for clinical research and one for basic sciences research.
 
This award is best suited to advanced students for whom conference attendance can be expected to have the largest career impact. The most competitive applications will be from presenting authors (either poster or platform presentations) who are in the mid to late stages of their educational experience. Apply by Friday, May 3, 6:00 pm.
 
Read the full RFA.

A prescription for physician frustration

Thursday, April 11, 2019

Jesse Wang remembers exactly when his crusade began.

The doctor he had seen since childhood turned a computer screen towards him during an office visit, in obvious frustration.

He couldn’t get the program started to make the required entries in Wang’s electronic medical record.

“This is absurd,” his doctor said. “I just want to be able to talk to you like I used to.”

Wang, who is pursing both a medical degree and a PhD in translational biomedical science at the University of Rochester, understands the frustration. Especially when he reads studies showing it’s not unusual for physicians to be online maintaining patient e-records from 5 in the morning until 9 at night.

“It’s not what I signed up for; it’s not what any doctor signed up for,” Wang says.

Thanks to Rochester’s Medical Scientist Training Program, which allows him to combine his interest in medicine with his passion for coding, Wang is well positioned to do something about the problem.

He’ll explain how, as one of four finalists in the ACP Innovation Challenge — a “Shark Tank”-style competition hosted by the American College of Physicians on April 13 in Philadelphia.

During an eight-minute pitch in front of a panel of judges — and an audience of 100 or more physicians — Wang will describe the virtual assistant he is creating. The device will use speech recognition and natural language processing to take over the job of maintaining patient e-records, freeing up physicians to concentrate on their patients.

“It would be like Amazon Alexa,” Wang says. “There would be a little speaker in the room that would be recording while your doctor talks to you and, based on that conversation, the device would know what to enter into the e-record.”

“I think the key that will make this work is that doctors are already encouraged to use what’s called a patient-centric communication style.”

For example, physicians are encouraged at the end of a visit to sum up a patient’s concerns and their plan to address them. Physicians would use a phrase like “to make sure I understand.” The virtual assistant would recognize the phrase as a cue to transcribe everything from that point to the next cue, such as when the physician says, “Do I have that right?”

The device would be less expensive than hiring a transcriptionist, Wang says, and less obtrusive for patients who find it hard enough to divulge personal health information when there’s just a physician in the room.

He already has a prototype for transcribing the summary portion of a patient’s visit.

‘Seamlessly see what the problem is — and fix it’

Wang, who is from Westford, Massachusetts, came to Rochester after majoring in physiology and neurobiology at the University of Connecticut.

He is now in his fourth year of Rochester’s Medical Scientist Training (MD/PhD) Program, which currently enrolls 66 students. The program incorporates the MD and PhD degrees into a cohesive curriculum that endows the select group of students with the clinical and basic science skills needed to understand disease and to translate that understanding into new therapies.

Students spend the first two years on their medical degrees, then complete their PhDs in four years before returning for the last two years of medical school.

Wang is pursuing his PhD in translational biomedical science under the direction of Henry Kautz, professor and former chair of computer science and founding director of the Goergen Institute of Data Science.

Wang is now thinking about forming his own company after he graduates. He would use his medical and computing background to pursue his virtual e-record assistant and other medical-related projects full time.

“Physicians go to programmers for help with a lot of things besides e-records. It might be for applications for telemedicine,” Wang says. “But it can be hard for them to convey what they need to a programmer who doesn’t have a medical background.

“I’ll have that background. I’ll be able to very seamlessly see what the problem is — and fix it.”

Danielle Benoit ‘Embodies the Spirit’ of Teaching and Mentorship

Thursday, April 11, 2019

Benoit in the lab

Danielle Benoit, an associate professor of biomedical engineering who has provided research experiences for more than 80 undergraduates in her lab, is the second recipient of the College Award for Undergraduate Teaching and Research Mentorship. (University of Rochester photo / J. Adam Fenster)

Danielle Benoit says it’s “an outstanding opportunity for everybody involved” when undergraduates do research in her lab.

Former students Tim Felong ’14, Amanda Chen ’14, and Janet Sorrells ’17 will all vouch for that.

“I wouldn’t be in medical school right now if it weren’t for Danielle’s mentorship,” says Felong, now at the University at Buffalo’s Jacobs School of Medicine and Biomedical Sciences.

Chen, a graduate research fellow in biological engineering at MIT, says, “Danielle’s lab was one of the biggest reasons why I chose to pursue a graduate degree. She gave me the opportunity to work on an independent project, publish a first-author paper, present at conferences, and more.”

And, “the more time I spend in academia the more amazed I am with how Dr. Benoit managed to keep up with so many things,” says Sorrells, now a graduate research fellow in bioengineering at the University of Illinois at Urbana-Champaign. “I’m very thankful for everything I learned from her.”

Benoit, an associate professor of biomedical engineering, is this year’s recipient of the College Award for Undergraduate Teaching and Research Mentorship at the University of Rochester.

The award, first presented last year, is funded by chemistry alumnus Frederick Lewis ’68 (PhD) and his wife, Susan Rice Lewis. It salutes tenured faculty members in Arts, Sciences & Engineering who teach large, introductory classes as well as advanced seminars and independent study projects, and who mentor research experiences, especially those that involve laboratory training in the sciences and engineering. (Read more about this new award recognizing faculty for their mentorship. )

The award will be presented to Benoit at the Undergraduate Research Exposition on April 19 at the Welles-Brown Room of Rush Rhees Library.

Benoit “embodies the spirit of this award through her dedication to undergraduate learning through classroom teaching, research experiences, and mentoring,” says Diane Dalecki, chair of the Department of Biomedical Engineering. “The research training and mentoring that undergraduates receive from Professor Benoit primes them for continued success as graduate students and throughout their professional careers.”

For example, several of the undergraduate students from her lab, including Chen and Sorrells, have received prestigious National Science Foundation graduate research fellowships to support their graduate studies.

Teaching at ‘multiple levels’

Benoit, who joined the University of Rochester in 2010, develops therapeutic biomaterials for tissue regeneration and targeted drug delivery. For example, she and her collaborators developed a device that selectively delivers drugs to sites of bone resorption to heal fractures and treat osteoporosis. She has also pioneered the development of hydrogel-based engineered extracellular matrices for bone and salivary gland tissue regeneration.

She has been lead, corresponding, or co-author of more than 70 papers in top journals; has received numerous grants, including an NSF CAREER award; has garnered nine approved or pending patents; and was recently elected a fellow of the American Institute of Medical and Biological Engineering.

She has provided research experiences for more than 80 undergraduates in her lab.

“For me, part and parcel of being a faculty member here is to teach on multiple levels, not just in the classroom but also in the lab, where I can teach undergraduate and graduate students alike the best, cutting-edge research practices,” Benoit says.

Students say the benefits of working in the Benoit Lab extend beyond the research skills they learn.

“Danielle has always been my go-to mentor for all sorts of advice – moral, social, intellectual – and was a powerful advocate for me if I ever found myself in a challenging situation,” Chen says.

Felong says he especially appreciated the “culture” of the lab, which was more like a “family environment. She takes the time to really get to know her students—their interests and hobbies. She hosts biannual parties, where you get to interact with her energy-packed, fun family. I think this openness and mutual appreciation for life inside and outside of work is really motivating for many people my age. I know it was for me.“

Seeing the potential in students

In addition to mentoring students in her lab, Benoit teaches courses including Advanced Biomaterials, Controlled Release Systems, Research Methods, and, starting this spring, Cell and Tissue Engineering, which is the capstone course for biomedical engineering majors with concentrations in that subfield.

She also developed and taught for eight years a biomaterials course, required of all biomedical engineering majors, that typically enrolls about 70 students. She designed the laboratory components of the course so they would dovetail with a biomedical computation and statistics course students take at the same time.

“Students complete laboratories in biomaterials one week, and then analyze data they collected by applying statistical approaches from the other course the following week,” Dalecki says. “This is an excellent pedagogical approach for students to understand how concepts they’re learning in different classes combine to enhance their skills as an engineer.”

Sorrells served as a teaching assistant for the biomaterials course under Benoit. She says Benoit brought the same level of “engagement” to the course that she brings to her lab. “She collected student feedback often and took it very seriously, trying different things to see how to best educate students and equip them with skills like scientific writing and knowledge of biomaterials.”

Benoit also supervises a senior design team each year, meeting with teams at least weekly, guiding them in their design and engineering, and mentoring them on teamwork and project management.

Perhaps the ultimate measure of a good teacher is the ability to inspire, motivate, and serve as a role model.

“Danielle suggested that I apply for the Research Initiative Award for Undergraduates, which is much like a grant application,” Felong says. “I never would have thought that I had a shot at winning that grant, but I applied and ended up getting it.” Benoit, as well as Andrew Shubin ’16 (PHD), ’18M (MD), the graduate student with whom Benoit paired Felong in her lab “saw potential in me that I didn’t see in myself.”

Chen says she “often reflects on mentorship behaviors that I hope to build into my own management style – now as I work with undergraduate trainees (at MIT), but also in my future career. And I find myself often thinking back to my experiences in Danielle’s lab.”

Latest Issue of Opportunities to explore - April 8-12, 2019

Monday, April 8, 2019

The new issue of opportunities to explore is out now! Remember that next week is graduate student appreciation week

Read The April 8-12, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Judy Conkling

Judy Conkling, Secretary

Judy serves as Secretary for the Office for Graduate Education and Postdoctoral Affairs (GEPA), acting as a secondary receptionist and helping to monitor department budgets. She also provides support to the UR Postdoctoral Association.

Trainees typically contact Judy with general inquiries, to discuss spending and reimbursement for events sponsored by GEPA and the Center for Professional Development, and to discuss Postdoctoral Association events.  To contact Judy, call her directly at 585-275-5022 or email Judy Conkling.

Research Roundup: Stephen Dewhurst Explores the Latest Bench-to-Bedside Projects

Monday, April 8, 2019

Transitions and Trials

Stephen Dewhurst, Ph.D., Vice Dean for Research

Almost 10 years ago, Brad Berk had the idea that the Medical Center should position itself to take a lead in the new field of cell-based therapies by constructing a manufacturing facility that could produce those cells under the highly regulated conditions that are required by the FDA. Brad’s vision was that, by doing this, we would enable UR to deliver first-in-human therapies to patients.

Fast forward, and the facility we built – the Upstate Stem Cell cGMP Facility (USCGF) – is working in coordination with Torque Therapeutics (Cambridge, MA) to produce modified T cells that are being infused into cancer patients as part of a clinical trial that started earlier this month.

As with most research partnerships, our relationship with Torque is fundamentally a relationship between people, and an expression of trust in the team led by USCGF Director Luisa Caetano-Davies. It’s worth noting that only two years ago, Luisa was a postdoctoral fellow in Chris Proschel’s lab. Her subsequent success and growth are the combined result of a lot of hard work, intelligence and – in no small measure – opportunities created by our URBEST program.

The Torque trial is a huge step for the USCGF because it represents the first time that a cell-based product produced by our facility has been administered to human subjects. But it’s also an important step for our Medical Center, when viewed in the broader context of our evolving approach to clinical trials.

Pat Ames is heading up a new Office of Clinical Research, working with Martin Zand, Steven Wormsley and many others to lead the implementation of a clinical trial management system to improve our clinical trials infrastructure. This system will streamline and automate many cumbersome clinical research processes and reduce administrative burden on our research teams, helping us conduct more clinical trials and offer more treatments to our patients and community members.

At the same time, Paul Barr in the Wilmot Cancer Institute (WCI) was just awarded a major new grant to support WCI involvement in National Cancer Institute (NCI) cooperative group clinical trials. This award establishes URMC as one of 30 lead academic sites within the NCI consortium, a designation rarely given to an institution that (currently) does not have an NCI-designated cancer center.

Perhaps most exciting of all, Mark Noble and Nimish Mohile recently received a highly encouraging score for a proposal that would (if funded, as we hope it will be!) launch a first-in-human trial of a new cancer treatment that is the result of fundamental research conducted in the Noble laboratory. Based on a new tumor-specific vulnerability, and discovery of existing drugs with the unexpected property of attacking this vulnerability, the new therapy eliminates cancer stem cells in glioblastoma (one of the most deadly human cancers).

This is exactly the kind of bench-to-bedside science that Brad envisaged ten years ago. We’ve made lots of progress, and there’s more to come. It’s an exciting time to be involved in research at the Medical Center.

Announcing Regulatory Science Student Competition Winners

Tuesday, April 2, 2019

Twelve teams competed this year in the sixth annual America’s Got Regulatory Science Talent student competition. Teams proposed a wide range of novel solutions to address the nine scientific priority areas outlined in the Food and Drug Administration’s (FDA) Strategic Plan for Advancing Regulatory Science. From a farm-to-table produce-tracking app to a public alert system for product recalls and disease outbreaks, this year’s competition was full of innovation. Learn more about the top three winners on the UR CTSI Stories blog.

Latest Issue of Opportunities to explore - April 1-5, 2019

Friday, March 29, 2019

The new issue of opportunities to explore is out now! Remember that next week is graduate student appreciation week

Read The April 1-5, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Colleen Bailey

Colleen Bailey, Secretary

Colleen serves as Secretary for the office of Graduate Education and Postdoctoral Affairs (GEPA), providing administrative support for the staff within GEPA, acting as the primary front desk liaison between students, faculty, staff and visitors and the GEPA Dean and staff. Colleen supports recruitment and admissions, the PREP and Summer Scholars programs, and Center for Professional Development (CPD) and Graduate Student Society (GSS) initiatives.

Trainees typically contact Colleen with general inquiries, to discuss CPD or GSS event management, and to schedule a meeting with Tracy Pezzimenti or Caroline Callahan. To contact Colleen please call 585-275-4522 or email Colleen Bailey.

John Lueck Publishes Study on New RNA Technology in Nature Communications

Thursday, March 28, 2019

Lueck

Michael Golinkoff (left), one of the founders of Emily’s Entourage; Phil Thomas (middle), cystic fibrosis researcher at UT Southwestern, John Lueck (right), assistant professor of Pharmacology and Physiology at URMC.

There are all sorts of “typos” in our DNA that can lead to disease. One kind of typo – a premature termination codon or PTC – is responsible for 10 to 15 percent all genetic diseases, including cystic fibrosis and Duchenne muscular dystrophy. PTCs lead to the production of short and often deleterious proteins.

A recent paper by John Lueck, Ph.D., assistant professor of Pharmacology and Physiology and Neurology, shows how high-throughput screening may be used to fix these typos and lessen disease severity. Published in Nature Communications, the study found that modifying tRNA (a type of RNA molecule that helps convert messenger RNA or mRNA into protein) can help the cell make a full length protein, even with a PTC in the middle of the gene. With this new technology to modify tRNA, the authors were able to use gene therapy to suppress faulty versions of a gene in skeletal muscle, and instead force the cells to produce a full-length protein.

At the moment, most investigational therapies for inherited diseases are focused on small molecules, which to this point have not been successful. “For many of these diseases, including cystic fibrosis and Duchenne muscular dystrophy, there are no therapies and patients rely on palliative care,” explains Lueck. “Our engineered tRNA platform puts another iron in the fire for development therapeutics and we’re hopeful that the technology can be translated into a viable treatment for patients in the near future.”

While these studies are still in the early stages, Lueck was recently awarded a unique pilot grant from Vertex Pharmaceuticals to continue this work. This work was funded by Emily’s Entourage and the Cystic Fibrosis Foundation and accomplished with the collaboration of researchers at the Cystic Fibrosis Foundations Therapeutics Lab, the Wistar Institute, University of Iowa, and Integrated DNA Technologies, Inc.

HSR PhD students will present research at 2019 ARM

Wednesday, March 27, 2019

Eight students from the Health Services Research and Policy PhD Program will be presenting their research at the 2019 Annual Research Meeting (ARM) in Washington, D.C.

“AcademyHealth’s Annual Research Meeting shares important findings and showcases the latest evidence to move research into action and improve health and health care”. Participants were selected on a competitive basis.

Xi Cen

  • Medicare’s Voluntary Lower Extremity Joint Replacement Bundled Payment is Associated with Exacerbated Racial Disparities in Hospital Readmissions

Michael Chen

  • Understanding the Role of Paternal Economic Support in Early Childhood Development Among Families with Unmarried Mothers
  • Shared Decision-Making and Cancer Patients’ Experience with Physician Communication

Alina Denham

  • Did Medicaid Expansion Matter in States with Generous Medicaid?
  • The Impact of the Affordable Care Act Medicaid Expansions on Mortality
  • Analyzing Opioid-Related Hospitalization Data: The Role of Increases in the Number of Recordable Diagnosis Fields

Lianlian Lei

  • Continuity of Care and Health Care Cost among Community-dwelling Older Veterans Living with Dementia

Wei Song

  • A Social Network Analysis of Nursing Home Medical Staff Organization

Sijiu Wang

  • Does the Dementia Care “National-Partnership” Improve Outcomes for Nursing Home Residents with Dementia?

Huiwen Xu

  • Rural Nursing Homes Were Associated with Lower Risk Adjusted Rates of Emergency Department Visit but Higher Mortality
  • Application of Machine Learning Ensemble Models to Predict Hospitalizations and Emergency Department Visits of Long-Stay Nursing Home Residents

Di Yan,  Sijiu Wang, Helena Temkin-Greener, Shubing Cai

  • Influence of Market Factors and State Policies on Access to High Quality Nursing Homes for Residents with Alzheimer's Disease and Related Dementias

Upcoming PhD dissertation defenses

Wednesday, March 27, 2019

Ninoshka Fernandes, biomedical engineering, “CD4+ Effector T cell interactions with the Extracellular Matrix at Sites of Inflammation.” 2:15 p.m. March 29, 2019, 3-6408 K-307 Auditorium (Medical Center). Advisors: Deborah Fowell and Edward Brown.

Abigail Freyer, chemistry, “Investigation of Doped Nanocrystals Utilizing Electrostatic Force Microscopy.” Noon, April 1, 2019. 209 Computer Studies Building. Advisor: Todd Krauss.

Tianran Hu, computer science, “Decoding Human Lives from Social Media Data.” Noon, April 3, 2019. Dewey 2110E. Advisor: Jiebo Luo.

Allison Li, pathology, “Assessing the Role of Myelodysplastic Syndrome (MDS)-Induced Bone Marrow Microenvironment Remodeling in MDS Progression.” 1 p.m., April 3, 2019. 1-7619 Lower Adolph (Medical Center). Advisor: Laura Calvi.

Mohammad Kazemi, electrical engineering, “Scalable Spin Torque Driven Devices and Circuits for High Performance Memory and Computing.” 2:30 p.m. April 8, 2019. Computer Studies Building 703. Advisor: Mark Bocko.

Thomas Nevins, physics, “Fronts and Filaments: Methods for Tracking and Predicting the Dynamical Effects of Advection on Excitable Reactions.” 11 a.m., April 12, 2019. Bausch and Lomb 106. Advisor: Douglas Kelley.

Study Aims to Predict, Prevent Acute Kidney Injury

Tuesday, March 26, 2019

Acute kidney injury — a sudden decline in kidney function — occurs frequently among hospitalized patients with serious, long-lasting effects and even increased risk of death. It’s often preventable, but we currently lack the ability to reliably predict when it will happen and to whom. That is why researchers at the Clinical and Translational Science Institute (UR CTSI) analyzed data from over 34,000 patients to develop a risk score for acute kidney injury that could help doctors intervene and prevent it.

Part of the reason we can’t predict when a patient will develop acute kidney injury is that while some risk factors are known, we often don’t use them in a coordinated way.  For example, machine learning papers often focus on factors that increase risk of acute kidney injury, such as diabetes and medications, but not those that lower that risk. On top of that, most previous studies have looked at single hospitalizations for all patients, many of whom have not been previously hospitalized. By not looking at patients’ past data, those studies missed the opportunity to discover health factors or patterns that reliably precede acute kidney injury.

Samuel Weisenthal, an MD-PhD student, and Martin Zand, co-director of UR CTSI, took a different tack, focusing on re-hospitalized patients. The pair and their colleagues analyzed electronic health record data from patients’ prior hospitalizations to identify factors that predict acute kidney injury. From those factors, they used machine learning to developed a risk score that could be calculated for patients at the time of re-hospitalization.

“Developing an accurate risk index for acute kidney injury in re-hospitalized patients could have a major impact on hospital care, particularly if it could allow preventive intervention or better tailored treatments from the time of hospital admission,” says Zand, who is also the senior associate dean for clinical research at URMC.

For example, acute kidney injury caused by radiocontrast dye or chemotherapy can be prevented by administering fluids or altering a patient’s treatment plan. When these factors are adjusted accordingly, patients fare better and the cost and length of stay can be decreased.

And while such predictive systems require extensive validation before clinical deployment, this work is a step toward creating acute kidney injury predictions, specifically for re-hospitalized patients.

“This study will hopefully help move us in the direction of an automated, locally trained tool that leverages sometimes hidden, longitudinal electronic health record data to estimate acute kidney injury risk without manually ordering tests or collecting and entering data,” says Zand.

Read the full study in PLOS One.

Cell Biology of Disease Alumnus appears on Fox Rochester

Monday, March 25, 2019

Cell Biology of Disease Alumnus and current Postdoctoral Fellow Zach Murphy appeared on Fox Rochester to discuss how red blood cells are produced in the body and how they affect infant development. See the video on the Fox Rochester Website

Genetics Day will feature lecture by UMass researcher

Monday, March 25, 2019

Phillip D. Zamore, Howard Hughes Medical Institute investigator and professor of biomedical sciences at the University of Massachusetts, will lecture on piRNAs and the Struggle to Reproduce at the 31st Annual Genetics Day, to be held 9 a.m. to 3:15 p.m. April 25 in the Class of ’62 Auditorium and Flaum Atrium.

Register for a poster presentation by 5 p.m. Monday, April 15. Cash prizes will be awarded for graduate student and postdoc posters.

New Issue of Opportunities to Explore - March 25-29, 2019

Monday, March 25, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The March 25-29, 2019 Issue

Meet the Graduate Education & Postdoctoral Affairs Team

Caroline Callahan

Caroline Callahan, Assistant Registrar

Caroline is the Assistant Registrar for Graduate Programs. She supports the student registration process and prepares student records. Trainees typically meet with Caroline to discuss registration issues, enrollment or degree verification, and commencement. To request a meeting with Caroline, please contact her directly (585) 273-1620 or Caroline Callahan.

New Issue of Opportunities to Explore - March 18-22

Monday, March 18, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The March 18-22, 2019 Issue

Meet the Graduate Education & Postdoctoral Affairs Team

Tracy Pezzimenti

Tracy Pezzimenti, Registrar

Tracy is the Registrar for Graduate Programs in the Office of Graduate Education and Postdoctoral Affairs.  She serves as the official steward of SMD graduate student records ensuring the integrity of all student records.  

While students are welcome to meet with Tracy to discuss any topic, students typically meet with Tracy to discuss matters dealing with academic policies, academic progress, registration issues, and academic support.  To request a meeting with Tracy, please contact her directly (585) 275-7288 or Tracy Pezzimenti.

Latest Issue of Opportunities to explore - March 11-15, 2019

Monday, March 11, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The March 11-15, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Stephen Naum, Assistant Director of Finance and Administration

Stephen Naum

Steve serves as the Assistant Director of Finance and Administration for the office for Graduate Education and Postdoctoral Affairs (GEPA), helping coordinate financial/HR-related issues and event logistics for the office and its programs. 

Trainees typically meet with Steve to discuss Center for Professional Development programming, policies related to the Graduate Student Society and Postdoctoral Association, and to schedule meetings with Sharon McCullough.  To request a meeting with Steve, please contact him directly at (585) 273-4650 or email Stephen Naum.

NYS Lawmakers vote to raise the smoking age from 18 to 21 - Rahman Lab interviewed

Wednesday, March 6, 2019

Lawmakers in the New York state Assembly have voted to raise the smoking age from 18 to 21.

The legislation, which passed the Democrat-led chamber on Wednesday, prohibits the sale of tobacco, as well as electronic cigarettes, to anyone under 21.

"I always thought that we were going to be the generation to stop smoking and then all of these new products came out and we are at step one," said Monica Jackson, a research assistant at the University of Rochester.

She said she doesn't smoke, but some of her friends do.

"I think just educating people and putting it in their heads this is not good for us," she added.

Jackson is part of a team of researchers at the university, including Dr. Irfan Rahman. Dr. Rahman has been helping conduct a study on the impacts of smoking and vaping for more than 10 years. Some of his work has also been published.

"This is really bad for high schoolers and middle schoolers when their lungs are developing, and if they vape it's interfering with lung development," he explained.

When asked about raising the age to buy tobacco and e-cigarettes, Dr. Rahman said it won't do much.

"The problem will never be solved by increasing the age. Overall it will not address the issue of toxicity and diseases," he said.

Throughout the years, Dr. Rahman says he's studied the evolution of different products to consume tobacco and nicotine.

When it comes to research on Juul products, he said, "we found metals such as copper, we published a paper, we found lung injuries, inflammation and stress in the lungs."

The elevated smoking age is already the law in seven states, and several cities around the country, including New York City.

Some people think passing such a law is going too far.

"The idea for them to choose when they finish high school when they become adults it's more applicable, so i think 19 would be more of an applicable age," said James McGuinness a Rochester resident.

Brandon Barr is the manager of Exscape Smoke Shop and Vapor Lounge. He said the age of 21 at least is giving you more life experience, and more of a chance to educate yourself about the thing you want to do.

He said if the law is passed, it likely won't impact his business directly.

"I think convenience stores and things like that probably will because they have more of a high customer volume," he added.

Barr said the topic of education should be at the center of this debate. He said he works to educate all of his customers about what they are buying.

"Some of these very high level nicotine juices if you were to put them in certain kinds of vapes it can put so much nicotine into you - you could get sick," he said.

The measure is backed by Governor Andrew Cuomo, and has broad support in the Democrat-controlled state Senate, where it has yet to be scheduled for a vote.

Cuomo released a statement after the Assembly passed the bill.

"The lifelong health effects and human misery caused by tobacco use cannot be understated and New York needs to do everything in its power to keep tobacco products out of the hands of our young people. That's why I made raising the age of tobacco sales to 21 one of the first proposals of my Justice Agenda and I applaud the Assembly and particularly Assembly Member Rosenthal for taking action on this very important issue today. I urge the Senate to follow suit and help make this a stronger and healthier New York for all."

Julie Hart of the American Cancer Society Cancer Action Network called the measure "common sense" and said it will reduce the number of young people who become addicted.

Read More: NYS Lawmakers vote to raise the smoking age from 18 to 21 - Rahman Lab interviewed

Reshaping our understanding of how the brain recovers from injury

Tuesday, March 5, 2019

New Medical Center research in the journal Proceedings of the Royal Society B sheds light on how the damage in the brain caused by a stroke can lead to permanent vision impairment. The findings could provide researchers with a blueprint to better identify which areas of vision are recoverable, facilitating more effective interventions to encourage vision recovery.

“The integration of a number of cortical regions of the brain is necessary in order for visual information to be translated into a coherent visual representation of the world,” says Bogachan Sahin, an assistant professor of neurology and co-author of the study. “And while the stroke may have disrupted the transmission of information from the visual center of the brain to higher order areas, these findings suggest that when the primary visual processing center of the brain remains intact and active, clinical approaches that harness the brain’s plasticity could lead to vision recovery.

The research has formed the basis of a new clinical trial for stroke patients with vision loss that is now under way at URMC and lead by Sahin. The study involves a class of drugs called selective serotonin reuptake inhibitors, the most common of which is the antidepressant Prozac. The inhibitors are known to enhance neuroplasticity – the brain’s ability to rewire itself and form new connections to restore function after damage. The hypothesis is that the drug will help restore vision by fostering the development of new connections between areas of the brain necessary for interpreting signals from the healthy eye cells.

A stroke in the primary visual cortex can result in blind areas in the field of vision. While some patients spontaneously recover vision over time, for most the loss is permanent. A long-known consequence of damage to neurons in this area of the brain is the progressive atrophy of cells in the eyes, called retinal ganglion cells. When this occurs, it becomes more likely that the person will not recover vision at that location.

The new research involved 15 patients treated at Strong Memorial and Rochester General Hospitals for a stroke that affected the primary visual processing area of the brain. The participants took vision tests, underwent scans in an MRI to identify areas of brain activity, and were administered a test that evaluated the integrity of cells in their retina.

The team found that the survival of the retinal ganglion cells depended upon whether or not the primary visual area of the brain to which they are connected remained active. Eye cells that were connected to areas of visual cortex that were no longer active would atrophy and degenerate, leading to permanent visual impairment.

However, the researchers observed that some cells in the eye remained healthy, even though the patient could not see in the corresponding field of vision. This finding suggests that these eye cells remain connected to unscathed neurons in the visual cortex and that visual information was making its way from the eyes to the visual cortex, even though this information was not being interpreted by the brain in a manner that allowed sight.

Read More: Reshaping our understanding of how the brain recovers from injury

Latest Issue of Opportunities To Explore - March 4-8, 2019

Monday, March 4, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The March 4-8, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Eric Vaughn

Eric Vaughn, M.Ed., Director of Career Services, Center for Professional Development

Eric serves as the Director of Career Services and assists graduate students, postdoctoral trainees and alumni with career service and employment search needs in the office for Graduate Education and Postdoctoral Affairs (GEPA).

While trainees are welcome to meet with Eric to discuss any topic, trainees typically contact Eric to discuss career related topics including career exploration, CV/resume and cover letter writing, job search strategies, employment application assistance. interviewing techniques, mock interviews, LinkedIn profile development, networking strategy and Individual Development Plans (IDP). To request a meeting with Eric, please complete an online REDCap Center for Professional Development Service Request.

Grant Marks Two Decades of NIH Support for Muscular Dystrophy Research

Tuesday, February 26, 2019

Deposits of toxic RNA (red) are seen here inside muscle cell nuclei (blue) from an individual with myotonic dystrophy

The University of Rochester Medical Center (URMC) has received $8 million from the National Institutes of Health (NIH) to support pioneering research on muscular dystrophy. The grant, which is a renewal of URMC’s Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, will fund ongoing work to investigate the genetic mechanisms and progression of this complex multi-system disease, research that has led scientists to the threshold of potential new therapies for myotonic dystrophy.

“The mission of the URMC Wellstone Center is to promote research that leads to effective treatments for muscular dystrophy,” said Charles Thornton, M.D., a professor in the URMC Department of Neurology and director of the URMC Wellstone Center. “This new funding will enable us to continue a research program that has been forged from a true partnership between bench scientists, clinical researchers, and patients and their families.”

URMC is home to one of six NIH-designated Wellstone Centers in the nation. URMC was selected in the first cycle of funding when the program was launched 16 years ago and is the only Wellstone Center that has been continuously funded since the program’s inception. With the current award, URMC has received a total of $29.8 million in NIH funding to study the disease since 2003.

The URMC Wellstone Center focuses on myotonic dystrophy, a disease that can be lethal in infants and adults and is characterized by progressive disability. Researchers at URMC have been studying myotonic dystrophy for more than 30 years and their work has transformed our understanding of the biological mechanisms of the disease. The new funding will support a long-standing collaboration between researchers at the University of Rochester and RNA scientists at the University of Florida.

Approximately 40,000 Americans have myotonic dystrophy, which is one of the most common forms of muscular dystrophy. People with the disease have muscle weakness and prolonged muscle tensing (myotonia), which makes it difficult to relax muscles after use. Eventually many patients have difficulty walking, swallowing, and breathing.

Read More: Grant Marks Two Decades of NIH Support for Muscular Dystrophy Research

New Issue of Opportunities to Explore - February 25-March 1, 2019

Monday, February 25, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The February 25-March 1, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Elaine Smolock, Ph.D. - Director of Writing Services, Center for Professional Development

Elaine Smolock

Elaine serves as the Director of Scientific and Scholarly Advancement/Director of Writing Services and assists graduate students, postdoctoral trainees and alumni with writing assistance in the office for Graduate Education and Postdoctoral Affairs (GEPA). In addition, Elaine also serves as PREP Education Director for GEPA.

While trainees are welcome to meet with Elaine to discuss any topic, trainees typically contact Elaine to discuss any writing project, including, but certainly not limited to, manuscripts, qualifying exams, grants, and dissertations. Each trainee who meets with Elaine will receive individualized assistance based on the trainee’s needs and writing project. To request a meeting with Elaine, please complete an online REDCap Center for Professional Development Service Request.

Xi Lin Wins Award

Tuesday, February 19, 2019

Xi Lin

Xi Lin, MS, 2019 ORS/RJOS Young Female Investigator Travel Grant awarded by the Orthopaedic Research Society, Women's Leadership Forum, and the Ruth Jackson Orthopaedic Society.

Xi is a Student of Lianping Xing, PhD, Pathology. Her research interest is OA pathogenesis: how macrophages contribute to localized inflammation through their effect on the lymphatic system.

New Issue of Opportunities to Explore - February 18-22, 2019

Monday, February 18, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The February 18-22, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Aleta Anthony

Aleta Anthony

Director of Graduate Enrollment

Aleta Anthony serves as the Director of Graduate Enrollment for PhD, Master’s, and Certificate programs for the School of Medicine and Dentistry (SMD) in the office for Graduate Education and Postdoctoral Affairs.

While students are welcome to meet with Aleta to discuss any topic, students typically meet with Aleta to discuss the admissions process for SMD programs including how to apply, application requirements, recruitment events, and general application questions.  To contact Aleta, please contact her directly at (585)275-0102 or email Aleta Anthony.

Mason Doolittle Awarded ASBMR Travel Grant

Friday, February 15, 2019

Madison Doolittle

Madison Doolittle, M.S., Current Ph.D. Trainee in the Cell Biology of Disease program at the School of Medicine and Dentistry was awarded an ASBMR Travel Grant to attend the Herbert Fleisch Workshop in Brussels Belgium March 2019. Madison is a student of Cheryl Ackert-Bicknell, PhD, CMSR., his research focus is on Identification and Characterization of Novel Genetic Determinants of Osteoporosis and Bone Mineral Density (BMD)

Matt Ingalls wins Prestigious Poster Prize at Gordon Conference

Friday, February 15, 2019

Matt Ingalls With Poster
Matt Ingalls With Poster

Matt in group with awards

Matt Ingalls with other award winners

GDSC student Matt Ingalls won an award for his poster presentation at the 2019 Gordon Research Conference for Salivary Glands and Exocrine Biology in Galveston, Texas (February 2nd – 8th). The GRC brought together leading researchers in the field of salivary gland biology from around the world. Matt’s poster, titled “Lineage Tracing Following Radiation Treatment Unveils Intrinsic Regeneration Potential in Adult Salivary Glands”, highlights differences in radiation response between the submandibular and parotid  salivary glands. Utilizing lineage tracing models his work demonstrates the intrinsic regeneration potential of the adult salivary gland. The NIH-supported research was conducted in the laboratory of Dr. Catherine Ovitt and was co-authored by E. Maruyama and P. Weng. -- Congratulations Matt!

Kristen Bush Marshall Successfully Defends Her Thesis

Monday, February 11, 2019

Kristen Bush

Kristen Bush Marshall successfully defended and submitted her thesis for the PhD in Translational Biomedical Science, with a focus in Infection and Immunity: From Molecules to Populations

Dr. Bush Marshall's research focus was The use of electronic health records (EHR), predictive analytics, and network science to understand infection mobility and improve patient outcomes. Her research was conducted in the labs of Dr. Martin Zand Dr. Gourab Ghoshal

She will be starting a postdoctoral position with her mentor, Dr. Martin Zand on 2/16, and will be heading down to the CDC for the EIS Fellowship starting in the summer

New Issue of Opportunities to Explore - February 11-15, 2019

Monday, February 11, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The February 11-15, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Sharon McCullough, Director, Graduate Education and Postdoctoral Affairs

Sharon McCulloughSharon serves as deputy to Dean Libby and directs the day-to-day operations and staff in the office for Graduate Education and Postdoctoral Affairs (GEPA).

While students and postdocs are welcome to meet with Sharon to discuss any topic, trainees typically meet with Sharon to discuss Center for Professional Development initiatives, trainee organization matters (including the Graduate Student Society and Postdoctoral Association), postdoctoral policies/appointments and related concerns, and student HR/payroll matters. To request a meeting with Sharon, please contact Steve Naum at (585) 273-4650 or email Stephen Naum to request an appointment with Sharon.

PREP Scholar Seble Negatu Receives Award

Monday, February 11, 2019

Seble Negatu – PREP Scholar in the laboratory of Dr. Deborah Fowell

Seble Negatu was one of 9 recipients of the American Association of Immunologists (AAI)-sponsored immunology presentation awards at the ABRCMS meeting in November 2018 in Indianapolis, IN. https://www.abstractsonline.com/pp8/#!/5759/presentation/882

At the meeting, AAI members and meeting chairs, Robert Binder and Cherie Butts, also presented Seble with a 2019 AAI Young Scholars Travel Award, to attend the 2019 AAI Annual Meeting this May in San Diego.

New Issue of Opportunities to Explore - February 4-8, 2019

Monday, February 4, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The February 4-8, 2019 Issue

Meet The Graduate Education & Postdoctoral Affairs Team

Rick LibbyDr. Rick Libby, Senior Associate Dean for Graduate Education and Postdoctoral Affairs

In addition to being Dean, Rick is a Professor of Ophthalmology and Biomedical Genetics, and a member of the Center for Visual Science.

While students and postdocs are welcome to meet with Rick to discuss any topic, trainees typically meet with Rick to discuss concerns related to coursework, research or related academic progress, and program/committee/advisor dynamics. To request a meeting with Rick, please contact Benjamin Lovell at (585) 275-2933 or email Benjamin Lovell.

GDSC student Adrian Molina-Vargas co-founds ADSE chapter to tackle underrepresentation in STEM

Friday, February 1, 2019

February 1, 2019

students posing for a group portrait

In the front row from the left, Keon Garrett, Ellen Matson, Raven Osborn, and Antonio Tinoco Valencia; and in the back row from the left, Marian Ackun-Farmmer, Heta Gandhi, Adrian Molina Vargas, Shukree Abdul-Rashed, and Liz Daniele are among the founding members of the new Rochester chapter of the Alliance for Diversity in Science and Engineering. (University of Rochester photo / J. Adam Fenster)

Raven Osborn thought long and hard about continuing a PhD at the University of Rochester. Other minority students she knew at the Medical Center had also felt the isolation, the constant “being on edge” and “code-switching”—shifting the way they express themselves—that comes with being an underrepresented minority in a STEM field.

“Can I do this for another five and half years?” she wondered.

Antonio Tinoco, a DREAMer who was born in Mexico and raised in Los Angeles, is a fourth year PhD student in the department of chemistry on the River Campus. He can remember only one or two occasions when a visiting faculty member of underrepresented minority background was invited to give a seminar in his department.

“My goal is to go into academia to be a professor, do research, and teach. But there are so few examples to follow,” he says. “I don’t even know of anyone who, as a DACA recipient or DREAMer, is a professor in chemistry. So, I could easily tell myself nobody has done it; it’s impossible; maybe I should look for something else.”

Instead, Tinoco, Osborn, and five other graduate students have banded together to form the University of Rochester chapter of the Alliance for Diversity in Science and Engineering (ADSE). The mission of the national ADSE, which was founded in 2014, is to increase the participation of underrepresented groups in academia, industry, and government through graduate student organizations that reach out to students and scientists of all ages and backgrounds.

Other ADSE chapters are at the University of California campuses at Berkeley and Davis, the University of Central Florida, the University of Colorado, Columbia University, Drexel University, Georgia Institute of Technology, University Maryland, New York University, Northeastern University, and Texas A&M.

Tinoco, the president and founding member of the new chapter, says its immediate goals are twofold:

  • Establish a diversity lecture series to bring underrepresented faculty from other universities to Rochester. “It would be an opportunity for underrepresented minority students here to say ‘Wow, there’s someone out there like me who is making it, so maybe there’s hope for me.’” Underrepresented minority postdoctoral fellows would also be invited, especially ones who might be interested in eventually teaching here, Tinoco says.
  • Provide a space where underrepresented graduate students in STEM fields from across the University can meet, network, and hold workshops and panels to openly discuss the issues they face. “If we can openly discuss these things, we won’t feel as isolated,” Tinoco says.

The chapter has been certified by the University and will receive funding through the University’s David T. Kearns Center for Leadership and Diversity. ADSE’s goals fall well within the Kearns Center’s mission to expand the educational pipeline through the doctoral degree for low-income, first-generation college, and underrepresented minority students, says Liz Daniele, the center’s assistant director for graduate diversity.

Inviting underrepresented faculty from other campuses to give a science-based talk, but also give a diversity-themed talk about their academic journey “is a great model,” she says.  “And that’s why Kearns is happy to support several semesters of lectures.”

“I think this is exactly the type of thing that the University needs right now,” says Ellen Matson, assistant professor of chemistry, who will be the chapter’s faculty advisor. She, too, is excited about the proposed diversity lecture series—as a way to inspire and motivate students to finish their programs and pursue STEM careers, and also “showcase our research programs and facilities to diverse early-career scientists and post-doctoral research fellows interested in pursuing independent academic research careers.”

“Overall, I think that the University of Rochester community, particularly at the graduate level, will really benefit from having a chapter of the Alliance for Diversity in Engineering and Science on campus,” Matson says.

Osborn, who is serving as the chapter’s treasurer, does not regret her decision to stay at Rochester to pursue a PhD in translational biomedical science. “I’ve been very lucky to work with faculty members like Tim Dye, Steve Dewhurst, and Juilee Thakar,” she says.

Osborn received a medical center community outreach award as a leader in the Rochester Young Scientists Club’s program, which encourages pupils at inner-city elementary schools to start thinking like scientists. She is excited to be serving on the search committee for a new vice president for equity and inclusion at the University.

She is hopeful that ADSE will bring together underrepresented graduate students, now separated by Elmwood Avenue “divide” between the River Campus and the Medical Center  and the separate “silos” of their STEM disciplines.

And she agrees with Matson that the University will benefit from having a chapter of ADSE.

“This is an amazing institution, and we have so many resources here. If we can make this a place where people who have different backgrounds feel comfortable, where their different perspectives are welcomed, it can only better the institution as a whole.”

Read More: GDSC student Adrian Molina-Vargas co-founds ADSE chapter to tackle underrepresentation in STEM

Former Biochemistry Student Jerry Madukwe, Ph.D. travels to West Africa to Speak With Students

Wednesday, January 30, 2019

Jerry with students

Jerry Madukwe, Ph.D., who received his Ph.D. in Biochemistry (2018), and is currently a postdoctoral fellow at Yale University, recently completed a 2-week science-outreach trip to West Africa. Jerry was invited by the West Africa Center for Cell Biology of Infectious Pathogens at the University of Ghana, and the Department of Life sciences at the University of Ilorin in central Nigeria to talk about the work he did as a PhD student and about graduate school in the United States. Jerry, who hails from Nigeria, and got his BS from Lee University in Tennessee, also used the opportunity to visit his former elementary school where he talked to fifth grade pupils about science (see photos), and to demonstrate DNA extraction from bananas. The kids were very excited by his visit, and Jerry found the experience very fulfilling.

Jerry in front of school

Jerry with students 2

Study suggests how high blood pressure might contribute to Alzheimer’s

Monday, January 28, 2019

The brain’s system for removing waste is driven primarily by the pulsations of adjoining arteries, University of Rochester neuroscientists and mechanical engineers report in a new study. They also show that changes in the pulsations caused by high blood pressure slow the removal of waste, reducing its efficiency.

This might explain the association between high blood pressure and Alzheimer’ disease, the researchers say. Alzheimer’s, the most common cause of dementia among older adults, is characterized by abnormal clumps and tangled bundles of fibers in the brain.

The study, reported in Nature Communications, builds upon groundbreaking discoveries about the brain’s waste removal system by Maiken Nedergaard, co-director of the University’s Center for Translational Neuromedicine. Nedergaard and her colleagues were the first to describe how cerebrospinal fluid is pumped into brain tissue and flushes away waste. Subsequent research by her team has shown that this glymphatic waste removal system is more active while we sleep and can be damaged by stroke and trauma.

This latest research shows “in much greater depth and much greater precision than before” how the glymphatic system functions in the perivascular spaces that surround arteries in the outer brain membrane, says Douglas Kelley, an assistant professor of mechanical engineering and an expert in fluid dynamics. His lab is collaborating with Nedergaard’s team as part of a $3.2 million National Institute on Aging grant.

For this study, Humberto Mestre, a PhD student in Nedergaard’s lab, injected minute particles in the cerebrospinal fluid of mice, and then used two-photon microscopy to create videos showing the particles as they moved through the perivascular spaces.

Read More: Study suggests how high blood pressure might contribute to Alzheimer’s

New Issue of Opportunities to Explore - January 28-February 1, 2019

Friday, January 25, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Read The January 28-February 1, 2019 Issue

Resource of the week

Edward G. Miner Library

Miner Library

Personal Librarian Program

All URMC students are paired with a personal librarian who is their "go-to" person for help doing research, using library resources and finding answers to questions. Personal librarians don't simply supply the needed information; they work with students to find it.

Graduate students work with the liaison librarian for their department. Check Miner's Staff Directory to find the liaison librarian for your department.

Writing Research Papers and Dissertations

Miner librarians can assist students who are writing research papers or dissertations by:

  • assisting students in their initial research by recommending appropriate databases and helping devise effective literature search strategies.
  • providing instruction on using RefWorks, EndNote or Mendeley to manage citations and format manuscripts.
  • helping students format their citations in APA, AMA and other citation styles

For assistance contact your personal librarian or the on-call librarian at Miner_Information@urmc.rochester.edu or 275-2487. Also see Miner's Writing, Citing & Publishing Guide.

iPad Information and Support

Miner's Computing Center supports iPad deployment and use for medical students and School of Medicine & Dentistry faculty. See iPad Information & Support for detailed information about installing the URMC Profile, the Notability app and Box.com.

Student E-Mail

Miner's Computing Center also supports email accounts for School of Medicine & Dentistry medical and graduate students, and School of Nursing students. We also provide documentation for smartphone and desktop email clients. Accounts are automatically created and issued to all medical and graduate students. Nursing student accounts are created on request. For help call the Computing Center Help Desk at 275-6865 or see Student Email Help.

Blackboard Support 

Miner's Computing Center can help with Blackboard login errors and other Blackboard-related problems. See Blackboard FAQ or contact the Computing Center at 275-6865 or Blackboard Support.

On-Call Librarian

An on-call professional librarian is available 9 AM - 5 PM (Monday-Friday) to consult with you on any information need including using library resources such as PubMed, CINAHL, EndNote, RefWorks and Mendeley, formatting citations and bibliographies, and designing literature searches. You can reach the on-call librarian at 275-2487, Miner_Information@urmc.rochester.edu, or by visiting Miner Library.

Other Services

  • Classes/One-on-One Sessions
  • Order Articles and Books Not Owned by Miner

For more information, please visit https://www.urmc.rochester.edu/libraries/miner/research/studentservices.cfm.

Dr. Kuan Hong Wang comes to the University of Rochester

Monday, January 21, 2019

We are pleased to welcome Dr. Wang to the University of Rochester Medical Center, the Department of Neuroscience and the Del Monte Institute for Neuroscience from the NIH.

Dr. Wang comes to us as the former chief of the Unit on Neural Circuits and Adaptive Behaviors at the National Institute of Mental Health. Dr. Wang received his B.A. in Biochemical Sciences from Harvard College and his Ph.D. from the University of California at San Francisco, where he studied the molecular regulators of sensory axon growth and branching during development with Marc Tessier-Lavigne. Dr. Wang obtained postdoctoral training with Susumu Tonegawa at the Massachusetts Institute of Technology, where he examined the ways in which cortical neurons respond to an animal’s experience by directly visualizing the molecular activity of a given set of neurons over several days in the live animal. With this approach, he revealed a physiological function of neural activity regulated gene Arc in sharpening stimulus-specific responses in visual cortex.

New Issue of Opportunities to Explore - January 14-18, 2018

Monday, January 14, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Resource of the week

Handshake logo

Handshake is your career connection resource, allowing you to:

  • Find internship and employment opportunities based on your interests
  • Discover when employers are heading to campus
  • Connect with alumni and employers
  • Attend events and programs in your field of interest

Access Handshake at the Professional Development Site.

Read The January 14-18, 2018 Issue

Research Roundup: Dealing with Failure and an Unfunded Grant Application

Wednesday, January 9, 2019

Stephen Dewhurst, Ph.D., Vice Dean for Research

It’s something we rarely talk about: how it feels when a grant application isn’t funded. And yet, it’s by far the most common outcome for any such submission – an unavoidable consequence of paylines that are in the low teens or single digits.

The months between the submission of a grant and its review pass surprisingly quickly. And then time slows to a crawl.  The self-doubt and self-criticism become more insistent.  And hope flickers – such a fragile thing, in the end.

Recently, after submitting a grant application, I found myself logging onto the NIH website every day after the review panel had met, to see if the scores had been posted.  Eventually, they appeared.

This particular grant isn’t going to be funded.

It’s a horrible feeling.  A private hurt that’s immeasurably hard to share with colleagues, family and friends. That’s because the narrative is one of failure.

But, I’ve chosen to write about it anyway – because we’ve all been here.  Because shame thrives in secrecy and loses its power when we talk about it (something I learned from Brené Brown).

What has helped is input from friends. One wrote:  “Thank you for sharing this. I’m glad you did. As Directors etc., we don’t share enough of the worries, the worthiness/unworthiness and the vulnerabilities that things like grants.... bring to the work and to our sense of ourselves as ‘good’ researchers, colleagues, leaders and people.”

She went on to say: “I wish I had great advice. I have nothing. Except that you are a good person, a good mentor.... and whatever happens, you will still be those things. If you receive the grant, you know what your work will be; if you don’t, you will have new and different work to do.”

She’s right.

It’s also true that a life in science requires resilience -- the ability to pick oneself up after a fall and to learn and improve from failure.  No one ever said that it would be easy.

In a few weeks, the summary statement will be released and I’ll start thinking (with my colleagues) about ways to address the reviewers’ concerns.  Until then, I’ll keep a space in my heart for these words of Samuel Beckett: “I can’t go on. I’ll go on.”

TBS Student Explores Drug Repurposing to Treat Infectious Disease

Tuesday, January 8, 2019

Infectious diseases still pose a big health risk in resource-limited areas of the world. A fourth-year student in the UR CTSI's Translational Biomedical Sciences Graduate Program, Marhiah Montoya, is exploring the possibility of repurposing pre-existing estrogen receptor drugs, like tamoxifen, to fight these infections. Read Montoya's mini-review in mBio.

TBS Student Dissertation Defense

Monday, January 7, 2019

UR CTSI Translational Biomedical Science graduate student, Kristen Bush Marshall, will defend her dissertation, titled, “Inpatient mobility to predict hospital-onset Clostridium difficile: a network approach,” on Friday, January 18.  She will discuss her use of electronic health records and network analysis of hospital-onset clostridium difficile, a life-threatening infection triggered by taking antibiotics. Martin Zand, M.D., Ph.D., has been her advisor and mentor for the past three years.
 
Bush Marshall is committed to becoming an epidemiologist, with a clear focus on infection prevention and understanding the fundamental mechanisms of disease transmission in communities and healthcare facilities.
 
Date: Friday, January 18
Time: 12:00 pm
Location: Helen Wood Hall Auditorium 1W-304

UR-RCMI Scholarly Exchange Request for Applications

Monday, January 7, 2019

Faculty, staff, and students at the University of Rochester can apply now for funding to support research collaboration activities with their counterparts from any institution in the Research Centers in Minority Institutions (RCMI) program.
 
The UR-RCMI Scholarly Exchange Program awards up to five projects a maximum of $3,000 each to help colleagues from different cultures, disciplines, and academic appointments build partnerships and produce abstracts, publications, or grant applications together and to foster the next generation of researchers from underrepresented populations.

Learn more and access the application from the UR CTSI Stories blog.
If you have questions, please contact Ivelisse Rivera, M.D., UR-RCMI Exchange Coordinator.
Applications are due Friday, January 25.
 

New Issue of Opportunities to Explore - January 7-11, 2018

Friday, January 4, 2019

The new issue of opportunities to explore is out now! This issue is packed with events, resources, funding opportunities and courses!

Resource Of The Week

ibiology logoJob Hunting in Industry: Searching, Applying, Interviewing, and Negotiating for a Scientist Position in Biotech and Pharma

Presented by Bill Lindstaedt (UCSF)

Job hunting in industry might seem like a mysterious or overwhelming task, but there are specific skills you can learn to make the process approachable and successful. In a series of four talks, Bill Lindstaedt, the Assistant Vice Chancellor of Career Advancement, International and Postdoctoral Services (CAIPS) at the University of California, San Francisco (UCSF), will show you how to effectively search, apply, interview and negotiate for industry scientist positions.

Watch our new video: Job Hunting in Industry: Searching, Applying, Interviewing, and Negotiating for a Scientist Position in Biotech and Pharma

Read The Latest Issue

In The News: URMC utilizes motion capture technology to study brain, how it ages

Wednesday, December 26, 2018

The following is an excerpt from an article by Norma Holland that originally appeared on WHAM 13:

Rochester, N.Y. – From Hollywood to Healthcare: Technology used to make movies is being used at the University of Rochester Medical Center to help scientists understand the brain and how it ages.

What researchers learn could help predict a person’s risk of developing Alzheimer’s disease.

13WHAM watched researchers in the Mobile Brain Body Imaging – or MoBi – Lab attach wires to a cap covered in electrodes. The cap picks up the brain wave activity of a volunteer, while infrared cameras surrounding him pick up how his body moves on a treadmill.

This lab is one of 12 around the world combining motion capture technology with brain scans used in real time.

“What we’re saying is: Let’s get people up, let’s get them in a walking situation where they’re solving a task, where we can kind of stress them a bit, and then we can ask, ‘How’s the brain working under duress?’ explained Dr. John Foxe, director of the Del Monte Institute for Neuroscience. “And that gives us a window into function, maybe like a neural stress test, akin to the cardiac stress test.”

Armed with that information, doctors hope to one day be able to predict a person’s dementia risk a decade before symptoms show up. It can also help give us clues about a person’s risk of falling as they get older.

Read More: In The News: URMC utilizes motion capture technology to study brain, how it ages

New Issue of Opportunities to Explore - December 24-28, 2018

Monday, December 24, 2018

Resource Of The Week

Science Careers from the Journal of Science offers a number of FREE online resources for graduate students and postdocs. Some of the resources include…

  • Career Tools including myIDP
  • Online job board with listings around the globe
  • Information on various career trajectories
  • Career featured articles
  • Online Science Webinars on new technologies, latest breakthroughs, and cutting-edge research
  • Employer profiles that allow you to learn about jobs at top organizations

Check it out at sciencemag.org/careers.

Read The Full Issue

Chavali, Couch, DeZoysa and Hao Win Sayeeda Zain Travel Award

Tuesday, December 18, 2018

The department is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Shashank Chavali, Tyler Couch, Meemanage Dudarshika DeZoysa and Fanfan Hao.

The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience. The next round of Sayeeda Zain Travel Awards will be offered in Spring 2019.

 

Thank you to all those who applied and congratulations to Shashank, Tyler, Dudarshika and Fanfan!

 

New Issue of Opportunities to Explore - December 17-21, 2018

Monday, December 17, 2018

Highlighted Event

(*) Faculty and Student Experiences with Online Learning at the University of Rochester

Thursday, December 13 | 12:00 pm-1:00pm | Genrich Rusling, LeChase Hall, River Campus
Part of the Fall 2018 University Online Learning Symposium Series. Lunch will be provided and advanced registration is required. Register for this event at this Survey Registration Page. Questions or accommodation request to adele.coelho@rochester.edu

Read The Full Issue

Study: Neurons in the Brain Work as a Team to Guide Movement of Arms, Hands

Tuesday, December 11, 2018

Hands waving in the skyThe apparent simplicity of picking up a cup of coffee or turning a doorknob belies the complex sequence of calculations and processes that the brain must undergo to identify the location of an item in space, move the arm and hand toward it, and shape the fingers to hold or manipulate the object. New research, published today in the journal Cell Reports, reveals how the nerve cells responsible for motor control modify their activity as we reach and grasp for objects. These findings upend the established understanding of how the brain undertakes this complex task and could have implications for the development of neuro-prosthetics.

“This study shows that activity patterns in populations of neurons shift progressively during the course of a single movement,” said Marc Schieber, M.D., Ph.D., a professor in the University of Rochester Medical Center (URMC) Department of Neurology and the Del Monte Institute for Neuroscience and a co-author of the study. “Interpreting these shifts in activity that allow groups of neurons to work together to perform distinctive and precise movements is the first step in understanding how to harness this information for potential new therapies.”

Read More: Study: Neurons in the Brain Work as a Team to Guide Movement of Arms, Hands

New Issue of Opportunities to Explore - December 10-14, 2018

Friday, December 7, 2018

A new issue of Opportunities to Explore is out with events, funding opportunities and resources 

This weeks Highlight:

Resource of the week

Have you joined the University of Rochester’s online community to connect with alumni, students, faculty, and staff? The Meliora Collective goes beyond what social media networks offer - an exclusive University of Rochester community of alumni, students, parents and friends who want to make meaningful connections for personal and professional exploration and growth. Check out a short video on the Collective at vimeo.com/289733971 . Sign up and join the Collective at thecollective.rochester.edu/

Read The Full Issue

Rochester graduate student named Schwarzman Scholar

Friday, December 7, 2018

University of Rochester graduate student Beixi Li is one of 140 students selected worldwide as a Schwarzman Scholar.

University of Rochester graduate student Beixi Li is one of 140 students selected worldwide as a Schwarzman Scholar. (University of Rochester photo / J. Adam Fenster)

University of Rochester graduate student Beixi Li has been named a 2019-20 Schwarzman Scholar, one of about 140 selected worldwide for this prestigious graduate fellowship. She’ll develop leadership skills and professional networks in a one-year master’s program at China’s elite Tsinghua University in Beijing, beginning next August.

“I’m really excited,” the Shanghai, China, native says. “After going through the application process and long interview sessions, it was great to know that everything I did was worth the effort. I’m thrilled to be part of this program.”

The international fellowship was established in 2016 with a $100 million donation by philanthropist Stephen Schwarzman, whose goal was to prepare the next generation of global leaders by providing an unparalleled opportunity to gain some understanding of China through an immersive experience. Students pursue a master’s degree in global affairs, with concentrations in public policy, economics and business, or international studies. They spend a year in an international community of thinkers, innovators, and leaders in business, politics, and society.

Nearly 2,900 candidates from around the world applied.

Li is currently pursuing a master of public health degree at Rochester’s School of Medicine and Dentistry and expects to graduate in May. Her thesis examines the potential impact of maternal dental amalgams (fillings) on offspring neurodevelopment.

As a Schwarzman Scholar, Li intends to concentrate in public policy. She plans a career in preventive medicine, with a focus on children, in the fields of environmental hazards, tobacco control, or infectious diseases.

“The world today is facing various public health issues, like environmental pollution, the Ebola viruses in Africa, the opioid epidemic in the United States, and smoking abuse among teens and adults,” Li says. “I’ve always believed that preventive medicine and public health are the most effective ways to save the lives of millions in the world.”

Li is the first Rochester recipient since Jintian (Jay) Li ’12 (no relation) was selected to the inaugural class. Suman Kumar ’19, a mechanical engineering major from Lalitpur, Nepal, was a Schwarzman Scholar semifinalist and one of around 400 who reached the interview stage of the competition.

“We are delighted and proud to have another Rochester student join the ranks of Schwarzman Scholars and hope that Beixi’s selection will inspire more students, including those in graduate and professional degree programs, to consider applying in the future,” says Belinda Redden, director of the Fellowships Office.

Li earned her undergraduate degree in preventive medicine from Xiangya School of Medicine at Central South University in Changsha, China, and is a licensed medical doctor in her native country. She began her Rochester graduate study program in fall 2017.

 

US News and World Report Article: What You Can Do With a Biology Degree?

Tuesday, December 4, 2018

Recently the US News and World report website published an article discussing what you can do with a biology degree. The article features input from URBEST Executive Director, Tracey Baas.

The article goes into detail on the types of jobs a graduate can expect, the variety of roles pursuing such a degree opens up for you including industry options while detailing further academic choices. To read the entire article, visit the US News and World Report Website

Read More: US News and World Report Article: What You Can Do With a Biology Degree?

New Issue of Opportunities to Explore - December 3-7, 2018

Monday, December 3, 2018

A new issue of Opportunities to Explore is out with events, funding opportunities and resources 

This weeks Highlight:

Bio Careers Webinar Series: “The Job Search Process: What Companies Look for When Evaluating Talent”

CPD Sponsored Workshop

Wednesday, December 5 | 1:00 pm-2:00 pm | 2-7539, URMC
In this seminar, Propel Careers will provide insight on the job search process and what companies look for when evaluating talent. Propel will discuss the importance of tailoring a resume and cover letter for a specific position. Propel Careers will also discuss how companies utilize resume databases and LinkedIn to identify talent. Propel will provide tips on how candidates can standout from the crowd. For more information about this event, please contact CPD-SMD-Grad@URMC.Rochester.edu. Trainees can also register and via the webinar by visiting the Gotowebinar site.

Read The Full Issue

Professor Harold Smith, Ph.D. appears on Evan Dawson Radio Program

Thursday, November 29, 2018

Harold C. Smith was a guest along with Bob Duffy (CEO of the Greater Rochester Chamber of Commerce), Jason Klimek (attorney with Boylan Code), Zachary Sarkis (co-founder of Flower City Solutions) and Jacob Fox (founder of Closed Loop Systems) on WXXI Connections with Evan Dawson on 11/21/2018 to address the opportunities and questions surround the emerging hemp industry in Up State NY.  (listen to Hemp101http://www.wxxinews.org/programs/connections?page=1&ajax=1)

Dr. Smith spoke regarding the future of labeling and dosing of THC-free and THC-containing products relative to what we understanding from scientific and clinical research. Having founded CannaMetrix, LLC, a New York based company, Dr. Smith seeks to establish through patent pending, cell-based assays, to raise the standards for product development and quality control so as to better information patient choices of products containing full spectrum plant cannabinoids or synthetic cannabinoids and advance medicinal use of cannabis.

Jean Bidlack Featured on WXXI's Second Opinion

Wednesday, November 28, 2018

Professor of Pharmacology and Physiology, Jean Bidlack, Ph.D. and her research were recently featured on WXXI's Second Opinion.

The Medical Innovations segment will air with the "Alcoholism" episode on WXXI where Dr. Bidlack discusses how when dopamine levels spike in the brain, it leads to the very strong reinforcing properties of addiction.

The program will air Thursday January, 3rd at 8:30pm but can be viewed below as well.

New Issue of Opportunities to Explore

Monday, November 26, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - November 26-30, 2018

23rd WCI Scientific Symposium

Thursday, November 15, 2018

Keynote Lecture

Keynote Lecture in Progress

Supriya Mohile

Supriya Mohile, M.D., M.S.

Judith Campisi

Judith Campisi, Ph.D. 

“This week GDSC assisted the Wilmot Cancer Institute (WCI) in hosting their Twenty Third Scientific Symposium for Cancer Research and Treatment.  Graduate Students working in basic, translational and clinical cancer research displayed posters of their respective cancer studies in the Flaum Atrium. GDSC and other faculty gave lectures; including Brian Altman, Stephano Mello, Dirk Bohmann, Vera Gorbunova, Joe Chakkalakal, Laurie Steiner, and Ben Frisch. Additionally, WCI professor Supriya Mohile, gave the Davey Award Lecture titled Improving Care Delivery for Older Patients with Cancer. Finally, Judith Campisi, Ph.D. of the Buck Institute for Research on Aging and USC Leonard Davis School of Gerontology presented the symposium's keynote lecture titled “Cancer and aging: Rival Demons?”

Congratulations to Phong Nguyen and Jose Suarez Loor for receiving ORS Travel Awards!

Thursday, November 15, 2018

Congratulations to PhD students Phong Nguyen and Jose Suarez Loor for receiving Orthopaedic Research Society (ORS) Travel Awards to attend the 2018 ORS Tendon Section Conference in Portland, OR! For more information, please see here: https://www.ors.org/tendon-2018-conference/

URMC Student/Trainee Travel Awards 2018 Request for Applications

Tuesday, November 13, 2018

Two travel reimbursement awards of up to $1,000 will be given this funding cycle (one for clinical research and one for basic sciences research) to support a University of Rochester School of Medicine & Dentistry medical student, graduate student, postdoctoral trainee, clinical resident, and/or clinical fellow to attend important national or international meetings at which they will present their research and make professional connections.
 
Eligible applications for the current cycle are for travel between September 1, 2018 and February 28, 2019. Submission Deadline: Friday, December 14, 2018, 6:00 pm. For questions, email Amy Blatt, M.D. or call 585-275-4912.

View the full RFA.
 
 

Congratulations Eugene!

Monday, November 12, 2018

Eugene Kim With Advisor Jianwen Que

Eugene Kim

We celebrated the successful PhD defense by Eugene Kim last Friday. Working with Jianwen Que, Eugene has identified a significant progenitor cell population in the early foregut. She used a combination of xenopus and mouse models to demonstrate that the transcription factor Isl1 enriched in the unique progenitor population regulates the separation of the esophagus from the trachea. These findings provide important insights into the pathobiology of a relatively common birth defect esophageal atresia with/without trachea-esophageal fistula (EA/TEF). Eugene has a passion for studying developmental biology and stem cells in regeneration, and she plans for a future career in these areas!

Congratulations to the 4th Annual Immune Imaging Symposium Poster and Image Winners

Monday, November 12, 2018

Wish the four winners a hardy congratulations when you see them.

Image Winner McRaePoster Winner Amitrano

Poster Winner PrizantPoster Winner Schrock

New Issue of Opportunities to Explore

Monday, November 12, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - November 12-16, 2018

Congratulations Fanju!

Thursday, November 8, 2018

Fanju Meng

On Thursday, Fanju Meng successfully defended his PhD thesis. Under mentorship of Dr. Benoit Biteau, Fanju’s studies focus on the regulatory network that coordinates stem cell proliferation and differentiation in the Drosophila intestinal epithelium. Using advanced fly genetics and cell biology methods, Fanju characterized the expression and role of several transcription factors in adult intestinal progenitors. His work significantly improves our understanding of the programs controlling stem cell function and establishes the fruit fly as a model to study these conserved, critical stem cell factors. His findings have been published in Cell Reports and Stem Cell Investigation. And there are additional papers in the pipeline! Fanju was a recipient of a NYSTEM training grant hosted by the Department of Biomedical Genetics, and the Goodman Doctoral Dissertation Fellowship from the University of Rochester. Fanju is now planning on continuing in his work in the field of stem cell and cancer biology using genetic model organisms – and we wish him the best of luck! You will be missed.

For further reading, please see:

Fanju Meng Successfully Defending His Ph.D. Thesis
Fanju Meng Successfully Defending His Ph.D. Thesis

GDSC Halloween Costume Contest!

Thursday, November 8, 2018

Last week GDSC held our Halloween Costume Contest. Our three GDSC student contestants can be seen below.

Derek Crowe as Bart Simpson

Derek Crowe as Bart Simpson

Anne Roskowski as Sailor Moon.

Anne Roskowski as Sailor Moon

Neal Shah as a Medical Garbed Squidward.

Neal Shah as a Medical Garbed Squidward

Derek Crowe earned a very close second place with 14 votes. While first place went to Anne Roskowski with 15 votes. Congrats Anne!”

Dumont Receives 2018 Outstanding Graduate Student Teacher Award

Tuesday, November 6, 2018

kielkopf lab door

 

Biochemistry professor Mark Dumont, Ph.D. is the recipient of the 2018 Outstanding Graduate Student Teacher Award. Established in 2013, this award is given to an outstanding graduate student teacher for record of excellence in classroom instruction. Mark was nominated by graduate students Brandon Davis, Ashwin Kumar and Matthew Raymonda.

This award was presented at the School of Medicine and Dentistry Convocation Ceremony, September 6, 2018.

The department would like to extend congratulations to Mark on this well- deserved honor.

New Issue of Opportunities to Explore

Friday, November 2, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - November 5-9, 2018

GDSC Fall Retreat

Thursday, November 1, 2018

Our graduate program in Genetics, Development and Stem Cells (GDSC) celebrated another successful season of research and academic growth. On the afternoon of Friday October 26th 2018, the faculty, students and families of GDSC held our Fall Retreat at the Ellison Park Pavilion Lodge. Among our many reasons to celebrate was our Department’s recent faculty expansion including, Brian J. Altman, Stephano Spano Mello, and Patrick J. Murphy. Welcome! We also celebrated the faculty promotion of Benoit Biteau to Associate Professor. Finally, we celebrated the future research of faculty members Margot Mayer-Pröschel, Douglas Portman, Chris Pröschel, and Andy Samuelson each of whom obtained prominent research grants earlier this year. Our festivities included pumpkin carvings, board games and a cocktail hour. There were also three hotly contested rounds of Science Trivia. (The final scores for the first and second place teams were separated by a margin of half a point!) The winning team “Smooth ER” included members Derek Crow, Li Xie, Shen Zhou, Yungeng Pang, Mark Noble, Daxiang Na, and Andy Samuelson. Additionally, Jessie Hogestyn won our “Hidden Facts” contest testing one’s knowledge of eccentric or esoteric trivia regarding GDSC faculty and students. Photos of GDSC’s genetic festivities can be seen below.

GDSC Fall Retreat 2018

New Issue of Opportunities to Explore

Friday, October 26, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 29-November 2, 2018

CMPP Graduate Student Published in Nature Communications

Wednesday, October 24, 2018

Edward Ayoub With PosterEdward Ayoub, a Graduate student in the Cellular and Molecular Pharmacology and Physiology PhD Program and member of Archibald Perkins Lab published in Nature Communications on 10/12/2018. More information can be found on the Nature Website.

Paper Title & Abstract

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang & Archibald S. Perkins

Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1 contributes to myeloid malignancy remains unclear. Here we describe a new mouse model that mimics the transcriptional effects of 3q26 rearrangement. We show that EVI1 overexpression causes global distortion of hematopoiesis, with suppression of erythropoiesis and lymphopoiesis, and marked premalignant expansion of myelopoiesis that eventually results in leukemic transformation. We show that myeloid skewing is dependent on DNA binding by EVI1, which upregulates Spi1, encoding master myeloid regulator PU.1. We show that EVI1 binds to the −14 kb upstream regulatory element (−14kbURE) at Spi1; knockdown of Spi1dampens the myeloid skewing. Furthermore, deletion of the −14kbURE at Spi1 abrogates the effects of EVI1 on hematopoietic stem cells. These findings support a novel mechanism of leukemogenesis through EVI1 overexpression.

New Issue of Opportunities to Explore

Monday, October 22, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 22-26, 2018

Research Roundup: Values

Monday, October 22, 2018

Stephen Dewhurst, Ph.D., Vice Dean for Research

A couple of weeks ago, I gave a presentation at the URBEST retreat, entitled “Mentoring Lessons: What my students have taught me”. It was a Pecha Kucha style talk - 20 slides, 20 seconds each; a little over 6 minutes total.

My ratio of prep time to presentation time was frightening.  But the process of constructing the talk was incredibly rewarding, because it forced me to reflect on the moments when my students have shown me - through their words and actions - what matters most.  

I’m referring to those moments when others teach us something important about ourselves, about our interconnectedness, and even about the workplace culture we aspire to create around us.  We’ve all experienced moments like these.  Moments that, even years later, can still inspire tears and feelings of deep gratitude.  

As I was putting my slides together, I got to thinking about Tony Broyld - who I first met as a middle schooler at Clara Barton School #2 in the City of Rochester.  He's now a Systems Engineer in his early 30s with two M.S. degrees from the University of Rochester and living in the greater New York City area. He is also the first member of his family to go to college.  Someone in whose life I was fortunate enough to make a real and profound difference and also someone who taught me a great deal about resilience.

If he were the only student who taught me something important about values, about what matters, this would be a short column. But of course, he wasn’t.

Almost every day, I find myself in awe of the people I’m privileged to work with.

Recently, I attended the annual picnic in my home department of Microbiology and Immunology. One of our students spoke to me about her journey to graduate school. How the kindness of a single mentor changed the course of her life, made her believe in herself, helped her see a different future, and brought her here to Rochester. 

She spoke also about her father and how he will spend the rest of his life in jail, a measure of how far her life has traveled from the path that it might otherwise have gone down.

She spoke from a place of love and appreciation - and left me feeling intensely honored to be a part of her education.

There are hundreds of stories like hers at our Medical center from people whose lives have been transformed by the power of their own courage and by the drive of their imagination and curiosity.  By their desire to learn, by this life in science that we share, and by the values that we talk about -- but don’t always appreciate or fully understand – until we see them up close and personal.

Former Tox Student Claire McCarthy, PhD Featured on NPR

Thursday, October 18, 2018

McCarthy

Early one morning in the spring of 2017, former Toxicology graduate student Claire McCarthy (Sime Lab) started her day as many don't: rolling dried rhinoceros dung into cigarettes and packing them into a machine that smoked them.

Although it might seem bizarre, McCarthy's purpose was serious: She wanted to know what happens when people breathe in dung smoke.

Dung smoke is no joke. Animal dung is used by millions globally for heating and cooking.

It's a dangerous practice. Burning biomass fuels (including animal dung as well as wood, charcoal, and plant matter) generates indoor air pollution, which caused 4 million deaths worldwide in 2012 according to the World Health Organization. Like cigarette smoke, biomass smoke has been linked to increased risk of lung diseases, such as chronic obstructive pulmonary disorder (COPD), lung cancer and respiratory infection.

Read More: Former Tox Student Claire McCarthy, PhD Featured on NPR

New Issue of Opportunities to Explore

Thursday, October 11, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 15-19, 2018

New Issue of Opportunities to Explore

Friday, September 28, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 1-5, 2018

CMPP Graduate Student Brandon Berry Wins Poster Award

Monday, September 24, 2018

The Wojtovich lab attended the Translational Research in Mitochondria, Aging, and Disease (TRiMaD) Symposium.  A yearly event that brings together approximately 150-200 scientists from the Northeast to discuss the role of mitochondria in aging and disease. 

8th Annual TRiMaD Website

Brandon Berry, Graduate Student in Wojtovich lab, was one of four recipients to win a poster award for his work entitled “Novel Optogenetic control of mitochondrial energetics rescues electron transport chain inhibition”

Adrian Moises Molina Vargas is awarded Graduate Alumni Convocation Award

Friday, September 14, 2018

Adrian (’18 University of Alcalá, Spain), one of three new 2018 recruits to the GDSC program was awarded the Graduate Alumni Convocation Award to recognize his promise for exceptional accomplishment in graduate studies. During his year of studying abroad at Tufts during 2017-2018, Adrian worked in the Mirkin lab to study the role of cdc13 mutations in genome instability.

In addition, Sarah Spahr (’18 Ohio State University) was nominated for the Irving Spar Fellowship and Tom O’Connor (’17 University of Buffalo) was nominated for the Newell Stannard Graduate Student Scholarship Award. Congratulations to all three!

Adrian Moises Molina Vargas Sarah Spahr Tom O'Connor

Adrian, Sarah & Tom

GDSC Team Participates in 6th annual Wilmot “Warrior Walk”

Friday, September 14, 2018

GDSC Team supports the 2017 Wilmot Cancer Warrior Walk
GDSC Team supports the 2017 Wilmot Cancer Warrior Walk

Students and faculty from Biomedical Genetics and the GDSC program attended the 6th Wilmot Cancer Institute Warrior Walk on Sunday. Aptly named the “NextGen Cancer Busters” to symbolize the graduate students and post-docs training to become cancer researchers, the GDSC team mingled with cancer survivors and family members, to support the fight against cancer. As one team member pointed out: “Meeting cancer survivors really helps put the work in the lab into perspective”.

In addition to the Cancer Survivor Walk, “NextGen Cancer Busters” also participated in the 10k and 5k events. Notably, Dalia Ghoneim (5k) and Adam Cornwall (10k) and placed 1st and 2nd in their group, and 2nd and 7th overall.  In addition, Scott Friedland and our new faculty addition, Brian Altman, both placed 4th in their age group for the 5k. Congratulations!!

Neuroscience Graduate Program Student Receives Award for SfN Trainee Professional Development

Tuesday, September 11, 2018

Photo of Emily WarnerEmily Warner was recently selected to receive a 2018 Trainee Professional Development Award (TPDA) from the Society for Neuroscience.  These are highly competitive awards and it is a great achievement for Emily.

The award comes with a complementary registration to the conference in San Diego and a monetary award of $1000.  Emily will present a poster at a poster session for other recipients and will be able to attend several Professional Development Workshops while at the conference.

Congratulations Emily!

New Issue of Opportunities to Explore

Monday, September 10, 2018

The latest issue of opportunities to explore is out(September 10-14), packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - September 10-14, 2018

New Issue of Opportunities to Explore

Monday, September 3, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - September 3-7, 2018

New Issue of Opportunities to Explore

Sunday, August 26, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 27-31, 2018

Neuroscience Graduate Program Student Receive 3 Convocation Awards

Wednesday, August 22, 2018

Congratulations to our NGP students for again earning these honors at this year's School of Medicine and Dentistry Convocation Ceremony.

  • Kathryn Toffolo (1st year):  Merritt and Marjorie Cleveland Fellowship Award
    • This fellowship was established in 1991 from Mr. and Mrs. Merritt Cleveland and is awarded to a Ph.D. student entering graduate study through the Biomedical Sciences Program with interest in developing a neuroscience-related research career.
  • Monique Mendes (4th year): Outstanding Student Mentor Award
    • This award, established in 2015, recognizes a student mentor who guides, supports and promotes the training and career development of others.
  • Gregory Reilly (1st year): J. Newell Stannard Graduate Student Scholarship Award
    • This scholarship was established by Dr. Stannard, Professor Emeritus, to recognize one deserving incoming graduate student for their commendable academic achievements. Dr. Stannard developed the world’s first doctoral program in radiation biology at the School of Medicine and was a faculty member for almost 40 years before retiring in 1975. He taught and mentored hundreds of students who went on to become leaders and experts in the field of radiation health.

Research Roundup: The Loneliness of Grant Writing

Wednesday, August 22, 2018

Stephen Dewhurst, Ph.D., Vice Dean for Research

Almost all of us, as researchers, spend a good deal of our time thinking about grant proposals.  That’s because grant funding gives us the means to explore our ideas, and to do the things we think are important.

We also all recognize that most grant applications will be rejected by the funding agencies to which we submit them.  So we become creatures of persistence.

What’s discussed less often, is the actual experience of grant writing. 

Its something we all do: at our desks, in coffee shops, at the kitchen table; wherever we can find a space for our laptop.  But we don’t often talk about how it feels.

There’s a strong sense of stepping out of your normal life.  For me - and I don’t think I’m unusual in this - it involves withdrawing from many of the other things I would normally do.  Not only professionally, but also family obligations and social interactions.  

This column, for example, was due a week ago.  But I deferred it, because I had a grant deadline yesterday.

Grant writing requires us to focus our thoughts to such an extent that we can sink into them; to become fully immersed.   The experience is intense, and it is also both lonely and isolating. 

That’s because the process of writing a grant is an exercise in disconnection.  An intentional unplugging.   

When I’m writing a grant, I often feel very distant from the people around me.  It’s as if they’re behind glass - because my mind is somewhere else entirely.  And then I’ll find myself alone in a quiet house, in the middle of the night, with nothing but my own thoughts for company.  Struggling to find the right words.  

What makes this more bearable is remembering why we’re asking for the money - what we plan to do with it - and knowing also that this is a shared experience, common to all academic scientists.  It’s a part of the life we choose.  

Those late nights, those doubts, those uncertainties - we’ve all been there.  It’s one of the things that bond us together. 

So I wanted to take a moment to acknowledge the hundreds of researchers at the medical center who are engaged in grant writing on any given day.  It’s their efforts that make the URMC’s research enterprise possible, and that make this a special place where discoveries happen every day.

School of Medicine Names New Dean for Graduate Education

Tuesday, August 21, 2018

Photo of Richard Libby

Richard T. Libby, Ph.D.

Richard T. Libby Ph.D., professor of Ophthalmology and of Biomedical Genetics at the University of Rochester School of Medicine and Dentistry, and a member of the University’s Center for Visual Science, has been named Senior Associate Dean for Graduate Education and Postdoctoral Affairs (GEPA), pending approval of the University Board of Trustees. Beginning Sept. 1, Libby will direct the School of Medicine and Dentistry’s Ph.D., postdoctoral and master’s degree programs. He succeeds Edith M. Lord, Ph.D., who served a decade in the role and is shifting her focus to microbiology and immunology research.

An innovative researcher in the neurobiology of glaucoma, Libby arrived in Rochester in 2006 after postdoctoral and fellowship experiences that enlightened him on the power of model genetics systems in the study of eye disease. Years spent training at the Medical Research Council’s Institute for Hearing Research in Nottingham, England, and the Jackson Laboratory in Bar Harbor, Maine, formed the foundation for his current laboratory, which is focused on understanding the cell signaling pathways that lead to vision loss in glaucoma.

Libby is director of the Cell Biology of Disease Graduate Program, has served on numerous academic committees integral to research activities and graduate education, and is a respected mentor and teacher. He has published, as author or co-author, more than 60 peer-reviewed scientific articles and numerous reviews, book chapters and commentaries, and has presented internationally on a range of topics in eye and vision research.

“Rick understands that excellence in a research enterprise is essential to attracting the best and brightest talent and has articulated a vision for further improving the experience here, making it clear to the outside world that Rochester is the best place to learn and study,” said Mark Taubman, M.D., CEO of the Medical Center and Dean of the School of Medicine and Dentistry at the University of Rochester. “He is a passionate scientist whose experience in a clinical department will bring valuable insight to graduate programs in basic and clinical research—a true asset to his role in helping prepare future generations of scientists.”

“Complementing his expertise in leading graduate programs, and thorough understanding of their needs, Rick has developed a thoughtful approach to what it will take to continue moving them forward. It’s clear that he’s driven by a desire to develop our trainees and motivated to give them the best graduate/postdoctoral experience possible,” said Stephen Dewhurst, Ph.D., Vice Dean for Research at the School of Medicine and Dentistry and Associate Vice President for Health Sciences Research at the University of Rochester. “In addition, having developed his own career in a somewhat untraditional way, Rick brings an added dimension to understanding and supporting others who are exploring diverse career options.”

Libby received a doctorate degree in biology from Boston College in the field of neurodevelopment.  He was a postdoctoral fellow at the Medical Research Council’s Institute for Hearing Research in Nottingham England, and a postdoctoral fellow at the Jackson Laboratory in Bar Harbor, Maine. He joined the School of Medicine and Dentistry faculty as an assistant professor in 2006, was named associate professor in 2012, and professor in 2018.

“Rick is a great choice to succeed Edith Lord as the Senior Associate Dean for Graduate Education,” said Dirk Bohmann, Ph.D., Donald M. Foster, M.D. Professor of Biomedical Genetics and Senior Associate Dean for Basic Research, who led the search committee. “He realizes that research excellence and successful graduate and postdoctoral programs are mutually dependent. You cannot have one without the other. He will be a passionate advocate for the graduate students and postdocs.”

“Under Dr. Lord’s leadership, GEPA has greatly enhanced the support and training of URMC’s graduate students and postdoctoral fellows,” Libby said. “In fact, GEPA has helped lead the nation in providing enhanced educational opportunities to ready trainees for the numerous careers available to the modern-day scientist. I am excited to be a part of this team. I look forward to further developing GEPA’s missions of providing world-class training for our graduate students and postdoctoral fellows, and to helping our trainees continue their important work focused on understanding human health and disease.”

Lord’s four-decade career in Rochester is dotted with milestones and accomplishments. She joined the School of Medicine and Dentistry faculty as a senior instructor in 1976 and rose through the ranks to professor in 1994. In 10 years as Senior Associate Dean, she worked to improve the experience of graduate students and postdocs in and outside the lab, adding Postdoctoral Affairs to the Office for Graduate Education’s name, standardizing salaries and benefits, and advocating on behalf of trainees. She spearheaded a revamping of the fundamental basic science courses, incorporating more workshops and active learning components and emphasizing team-based science. She also fostered professional development initiatives and guided efforts to support students’ health and wellbeing. Her return to the research lab will include focusing on an NIH grant to study the immune response in tumors.

New Issue of Opportunities to Explore

Friday, August 17, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 20-24, 2018

Ralph Jozefowicz Honored for Mentoring Next Generation of Leaders in Neurology

Tuesday, August 14, 2018

URMC neurologist Ralph Jozefowicz, M.D., has been awarded the American Academy of Neurology’s (AAN) Leading in Excellence through Mentorship award.  He received the recognition at the AAN’s 2018 annual meeting. 

Jozefowicz, a professor of Neurology and Medicine, is a nationally recognized leader and innovator in neurologic education and has received numerous awards and accolades from AAN, the American Neurological Association, the Fulbright Program, the Association of American Medical Colleges, and Jagiellonian University in Poland for his work in the field.

He currently serves as director for the second year medical student "Mind, Brain and Behavior" course and co-director of the third year Neurology Clerkship. He is also the Neurology Residency Program Director at the URMC.

You can read more about the award and perspectives from colleagues he has mentored over the years in Neurology Today.

MSTP Alum, Alan Kenny Headlines MSTP 18th Annual Retreat

Friday, August 10, 2018

2018 retreat photo

August 10, 2018 marked the Medical Scientist Training Program’s 18th Annual Retreat. The retreat was held at the Rochester Yacht Club, overlooking Lake Ontario and the Genesee River.

The Annual Retreat is an opportunity for the entire program to touch base and welcome incoming students. This year, the MSTP welcomed 8 new students: Catherine Beamish, Wash U., Zachary Christensen, UR 2nd year med. (Brigham Young U.), Ankit Dahal (U. Penn), Adam Geber (Columbia U.), Emily Isenstein (Cornell U.), Bryan Redmond (Xavier U.), Alison Roby (Penn St.), Matt Sipple (Cornell U.).

2018 MSTP Incoming Students
2018 MSTP Incoming Students

The Keynote this year (“Iterations of cross-talk direct differentiation in development”) was given by former URMC MSTP Student, Alan P. Kenny, MD, PhD, Assistant Professor, Pediatrics (Neonatology) at the University of Cincinnati Children’s Hospital, Cincinnati, OH. Dr. Kenny focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates.

Following the keynote, the morning science session concluded with several short-format research talks by Mark Kenney(M2, lab rotation, Summer 2018 - Edward Schwarz, PhD), Jonathan Gigas (G1, Vera Gorbunova, PhD), Karl Foley ( G2, Houhui Xia, PhD), Matthew Tanner (G3, Charles Thornton, MD), Colleen Schneider (G4, Bradford Mahon, PhD), and Evan McConnell, PhD (M3, Maiken Nedergaard, DMD, PhD).

After lunch, the program convened for a business meeting. Attendees of the Keystone MD/PhD Student Conference and the Class Council representative for American Physician Scientist Association (ASPA) reported on their trips to annual meetings and upcoming events. New Student Council members were elected at the end of the afternoon.

After closing the meeting, MD/PhD students met for conversation and drinks overlooking the water. Another successful year for the program!

New Issue of Opportunities to Explore

Friday, August 10, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 13-17, 2018

NGP Student Monique Mendes Selected as a Neuroscience Scholars Program Fellow

Tuesday, August 7, 2018

Photo of Monique MendesMonique was selected by the Society for Neuroscience's Professional Development Committee and its Diversity in Neuroscience Subcommittee as a Neuroscience Scholars Program Fellow.  This program is designed to provide underrepresented graduate students in neuroscience with career development and networking opportunities to help them with success going into the future.

The program provides the following benefits:

  • A mentoring team consisting of a senior mentor and a member of the Diversity in Neuroscience Subcommittee.  The team will discuss a fellow's research, career plans, and overall experience.
  • Two years of complimentary SfN membership.
  • A travel award to attend the SfN annual meeting each fall during the two-year program.
  • Up to $1500 in enrichment funds to support allowed professional development activities.

Congratulations Monique!

New Issue of Opportunities To Explore - August 6-10, 2018

Friday, August 3, 2018

This weeks events in Opportunities To Explore:

  • Page-Turners for Teaching - discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Center for the Integration of Research, Teaching and Learning (CIRTL) Webinar - Faculty Advising: What You Need to Know and How to Do It Well
  • Postdoctoral Association (PDA) Monthly Meeting

That's Just this week, there are opportunities, information and events going into September in the latest issue of Opportunities To Explore!

Opportunities To Explore - August 6-10, 2018

New Issue of Opportunities to Explore

Friday, July 27, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into Summer, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore - July 30-August 3, 2018

Edward Ayoub, CMPP graduate student in the laboratory of Dr. Archibald S. Perkins, was awarded an NRSA F31 beginning 8/1/18

Monday, July 23, 2018

Edward Ayoub - Recipient of a Two-Year Ruth L. Kirschstein National Research Service Award (NRSA)
Individual Predoctoral Fellowship (F31) August 1, 2018 – July 31, 2020

Thursday, July 19, 2018

Edward Ayoub, graduate student in the laboratory of Dr. Archibald S. Perkins was awarded a two-year Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship entitled, “Therapeutic Strategies for Anemia in 3q26 Rearranged Leukemia”.

Project Summary

According to the most recent NIH Cancer Statistics Review, leukemia, a cancer of blood cells, is the ninth most common type of cancer. Acute myeloid leukemia (AML) is an aggressive form of leukemia with high lethality (~75% of patients die 5 years after being diagnosed) characterized by anemia, and excessive proliferation of abnormal myeloid progenitor cells in the bone marrow (BM). Rearrangements of the chromosomal band 3q26 portend further reduction in survival, and lead to the overexpression of the oncogene Ecotropic Viral Integration Site 1 (EVI1). The severity of 3q26 rearranged AML, the lack of in-depth understanding of the role of EVI1 in leukemia, and the inadequate therapeutic strategies interested our lab and others to investigate EVI1 associated leukemogenesis. While previous groups used transplantation of BM virally transduced to overexpress EVI1, we are the first lab to recapitulate the effects of the 3q26 rearrangements in the mouse by establishing an inducible EVI1-overexpression model, which has provided us with new insights into the mechanisms by which EVI1 induces leukemia. We concluded using our in vivo and in vitro models that EVI1 causes myeloid expansion and blocks both erythropoiesis and lymphopoiesis. As an insight to the molecular mechanism, we previously documented that EVI1 binds to GACAAGATA, which overlaps with the binding site of the master regulator of erythropoiesis GATA-1. Additionally, our data indicate that EVI1 upregulates a previously published GATA-1 blocker, PU.1, and we showed that EVI1 binds to an enhancer upstream of PU.1 encoding gene (Spi-1). Thus, we hypothesize that EVI1 blocks erythroid differentiation by two mechanisms: 1) directly competing with GATA-1 for key genomic binding sites harboring EVI1/GATA-1 overlap motifs and 2) binding to Spi-1 enhancer and upregulating PU.1, which suppresses GATA1 function. We will investigate both hypothesized mechanisms using cutting edge techniques including ChIP-seq, ATAC-seq, and CRISPR under the training of my sponsor and collaborator. In order to translate the proposed mechanistic insights into clinical settings and therapeutic strategies, we will perform CRISPR library screening using an in vivo model to identify genes that reverse erythropoiesis blockage associated with EVI1-overexpression.  

In summary, this fellowship will focus on investigating erythropoiesis blockage and resulting anemia that might explain the increased lethality associated with 3q26 rearranged leukemia, and It will unveil new therapeutic strategies that reverse the leukemia-associated anemia.

New Issue of Opportunities to Explore

Monday, July 23, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into August, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore 7/23-7/27

New Issue of Opportunities to Explore

Friday, July 13, 2018

This Week

Town hall meetings are being held to allow students to meet the candidates for Associate Dean for Graduate Education. 

  • Denise Hocking | Monday, July 16 | 2:00 – 3:00 PM | 1-7619 Adolf Auditorium
  • Richard Libby | Tuesday, July 17 | 11:30 – 12:30 PM | 1-9576 Ryan Case Method Room
  • Edwin van Wijngaarden | Wednesday, July 18 | 12:00 – 1:00 PM | 1-7619 Adolf Auditorium

Also this week:

  • A webinar on leveraging your PhD for career success
  • Page-Turners for Teaching a new bi-weekly  discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Pride Parade - Walk with the University of Rochester in the 2018 pride parade will send a positive message of support to the LGBTQ community.

For more information on this weeks events as well as many, many other opportunities, check out this weeks issue!

Opportunities To Explore - July 16-20, 2018

New Frontiers in Research

Tuesday, July 10, 2018

Stephen Dewhurst, Ph.D., Vice Dean for Research

One of the great pleasures of serving as Vice Dean for Research is the opportunity to learn about - and share - the cutting edge research that's being done here at the Medical Center.  I've recently spoken with alumni, trustees and friends of the University across the country, as well as to key partners (and potential partners) for our new Empire Discovery Institute.  Each time, it's been tremendous fun to have colleagues explain to me the science that most excites them - and to then watch how it resonates with diverse audiences.

Today, I'm starting a new column that's intended to share some of the stories, breakthroughs and discoveries that are being made by the 3,000 researchers who work here.

In diverse fields, ranging from neuroscience, to cancer immunotherapy, to musculoskeletal research, to RNA biology, and immunology and infectious disease, Medical Center researchers are at the forefront of their fields.  For example: our basic scientists are unraveling the fundamental processes that regulate RNA metabolism and the trafficking of immune cells through tissue, while our Center for Health and Technology (CHeT) is working to enable anyone anywhere to receive care, participate in research, and benefit from resulting advances. 

Another area of remarkable strength is in augmented and virtual reality (AR/VR).  Multi-disciplinary teams spanning computer science, engineering, neuroscience, ophthalmology and visual sciences are creating complex virtual environments that will enable us to better understand how the brain integrates sensory data, and how that can be used to treat a wide range of neurological and neuropsychiatric conditions. 

In the coming months, I hope to go into greater depth about these and other advances - and to share details of how Medical Center researchers are advancing our understanding of fundamental biological processes, translating discoveries into new treatments, and leading the way in improving clinical and population-level care.

Isaac Fisher, 5th year graduate student in the lab of Alan V. Smrcka, won first place for his poster at the EB/ASPET meeting in San Diego

Monday, July 9, 2018

Group Photo-Isaac Fisher-Prize winning Poster from EB ASPET 2018

Congratulations to Isaac Fisher, a 5th year student in the laboratory of Dr. Alan V. Smrcka for receiving First Place in the Postbaccalaureate/Graduate Student category within the Division for Molecular Pharmacology!  We applaud your contributions to ASPET’s 2018 Student Competition.

The winners of the awards for the ASPET Student Poster Competition were announced at the Division Mixer on Tuesday, April 24 at EB 2018 in San Diego.

Poster Details

Title: Hydrogen Deuterium Exchange Mass Spectrometry Reveals Distinct Activation States of PCLb by G-Protein

Authors: Isaac Fisher, Meredith Jenkins, Greg Tall, John Burke, and Alan V. Smrcka

Isaac Fisher-Prize winning Poster from EB ASPET 2018

See Awards on ASPET website

New Issue of Opportunities to Explore

Thursday, July 5, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into July, we also have an employment and internship opportunity advertised in this issue. Check it out

 

 

Read More: New Issue of Opportunities to Explore

MSTP Student Wins Research Award from American Heart Association

Thursday, June 21, 2018

Jonathan Bartko, MS has received a two-year Predoctoral Fellowship Award from the American Heart Association (AHA).

Bartko is an MD/PhD candidate currently in his second year of the Cell Biology of Disease (Pathology) Graduate Program as part of the Medical Scientist Training Program (MSTP) at the University of Rochester.

He currently works in the lab of Marc Halterman, M.D., Ph.D. which specializes in stroke and cardiac arrest research. Bartko’s current project is entitled, “BDNF-TrkB Regulation of ER-Dependent Death in the Peri-Ischemic Cortex.”

NGP Student Receives Ruth L. Kirschstein Predoctoral Individual National Research Service Award

Thursday, June 21, 2018

Photo of Rianne StowellRianne Stowell, a fourth year NGP graduate student, has been awarded a two year NIH Fellowship award (F31) for her project titled, “Noradrenergic modulation of microglial dynamics and synaptic plasticity”. Rianne works in the laboratory of Ania Majewska, Ph.D.

The purpose of the Kirschstein National Research Service Award program is to enable promising predoctoral students with potential to develop into a productive, independent research scientists, to obtain mentored research training while conducting dissertation research.

Well done Rianne!

Event Recap: Pathology Research Day 2018

Monday, June 18, 2018

The annual Pathology Research Day event at the University of Rochester Medical Center was held on Monday, June 11, 2018.

The day included more than 50 poster presentations in addition to 12 oral presentationsgiven by Pathology residents and fellows, and graduate students in the Cell Biology of Disease Ph.D. Program.

This year’s keynote speaker was Andrew Folpe, M.D. who is professor and consultant for Anatomic Pathology at Mayo Clinic. His engaging and informative talk was titled, “Phosphaturic Mesenchymal Tumors: What I Have Learned.” A video recording of the keynote is available online (note: UR login is required to view).

The graduate program gave out several awards at a special reception at the end of the day, per below.

View Event Photos

Graduate Program Awards

  •         Outstanding Academic Excellence by a First Year Student – David Villani, MS
  •         Outstanding Program Contribution – Sarah Catheline, MS
  •         Robert Mooney Thesis Award – Irena Lerman, Ph.D.

Travel Award for Oral Presentation

  •      Madison Doolittle, MS

Poster Presentation Travel Awards

  •         Robert Hoff, MS
  •         Allison Li, MS
  •         Xi Lin, MS
  •         Robert Maynard, MS

New Issue of Opportunities to Explore

Friday, June 15, 2018

This Week in Opportunities To Explore:

Monday

  • LinkedIn Workshop: Utilizing LinkedIn to Market Yourself in Today’s Job Search Environment
  • NextCorp SBIR Road Show (Postdoc Professional Development Opportunity)

Tuesday

  • Post-doc Only Grant Writing Workshops

Wednesday

  • Graduate Student Society Coffee Hour
  • GoToWebinar - Career Path: "Negotiating Your Way to a Job in Academia"
  • Webinar on Preparing Your Application to the NIGMS PRAT Program
  • Page-Turners For Teaching

Thursday

  • Ubiquitous Stress: Responsive Mentorship in the Higher Education Mental Health Crisis

Saturday

  • GSS Bristol Mountain Aerial Adventure Park

That's just this week, there are several other Opportunities in the current issue, check it out!

Opportunities To Explore - June 18-22, 2018

Biochemistry & Biophysics Students Going Places

Tuesday, June 12, 2018

By Dr. Joseph Wedekind

The Department of Biochemistry & Biophysics is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Debapratim Dutta, Sierra Fox and Hong Zhu.

The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience.

Debapratim (Dave) Dutta is presenting a poster and was invited to give a talk at the Annual RNA Society Meeting (Berkeley, CA). Sierra Fox presented a poster and was a Keystone Symposia Future of Science Fund Scholarship recipient at the Keystone Symposia in Chromatin Architecture and Chromatin Organization, and Gene Control in Development and Disease Symposia (Whistler, BC, Canada). Hong Zhu presented a poster at the III International Conference on Vaccines Research and Development (Washington, DC).

Debapratim (Dave) Dutta

Debapratim (Dave) Dutta

Sierra Fox

Sierra Fox

Hong Zhu

Hong Zhu

Neuroscience Grad Student Awarded NIH Diversity Fellowship

Tuesday, June 12, 2018

Photo of Monique MendesMonique S. Mendes, a neuroscience Ph.D. student, is the first University of Rochester Medical Center (URMC) graduate student to receive a prestigious diversity award from the National Institute of Neurological Disorders in Stroke (NINDS).  Mendes works in the laboratory of Ania Majewska, Ph.D. and studies the role that the brain’s immune cells play in development, learning, and diseases like Autism.

Mendes, originally from Kingston, Jamaica, received her undergraduate degree in Biology from the University of Florida. She came to URMC in search of a robust program that focused on glial biology and a collaborative environment.  She chose the Del Monte Institute for Neuroscience to complete her thesis work due in part to Majewska’s record of mentoring students and her lab’s reputation for conducting leading research in brain development. 

Mendes has been awarded a F99/K00 NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) fellowship from NINDS.  The award was created to provide outstanding young neuroscientists from diverse backgrounds a pathway to develop independent research careers.  Unlike traditional graduate student fellowships, this award provides research funding for 6 years, including dissertation research and mentored postdoctoral research career development.

Read the local Jamacian Observer newspaper article.

Read More: Neuroscience Grad Student Awarded NIH Diversity Fellowship

New Issue of Opportunities to Explore - June 11-15, 2018

Friday, June 8, 2018

This week is the PREP Symposium, the PDA monthly meeting, mid-week brings the Online Career Conference for PhDs and on Thursday students and alumni can learn about The Meliora Collective the University's online network for Alumni and Students in the morning and attend the National Research Mentoring Network (NRMN) Career Development Webinar- Submitting to Journals for Publication in the afternoon.

That's just this week, this issue contains events and opportunities covering June and July, click the link below to read more.

New Issue of Opportunities to Explore - June 11-15, 2018

GSS Annual Poster Session - Travel Award Winners Announced

Thursday, June 7, 2018

Congratulations to our most recent GSS poster session Travel Award Winners!

Lara Terry, 3rd year student in David Yule Lab: 2nd place – Title: Effects of Missense Mutations on Inositol 1,4,5-trisphosphate Receptor Mediated Calcium Release.

Si Chen, 4th year student in Chen Yan lab: 3rd place – Title: PDE10A Inhibition and Deficiency Attenuate Pathological Cardiac Remodeling

Latest Issue of Opportunities To Explore - June 4-8, 2018

Friday, June 1, 2018

The latest issue of Opportunities to Explore is out. Get all the latest updates on events, grants, reading resources and more.

Latest Issue of Opportunities To Explore - June 4-8, 2018

Fourth year NGP Graduate Student Publishes in Journal of Neuroscience

Tuesday, May 29, 2018

Fourth year NGP graduate student Patrick Miller-Rhodes (Gelbard lab) has recently published a single author review in Journal of Neuroscience (Journal Club, J Neurosci. 2018 38(19):4457– 4459) tackling the fascinating and timely topic of the heterogeneity of microglial mechanisms that contribute to normal brain functions such as synaptic plasticity. In this publication, Patrick highlights a recent study by NGP alumna Rebecca Lowery (Majewska lab; Glia 65(11):1744-1761), showing that microglial CX3CR1 loss does not affect multiple forms of plasticity, to make his point that the mechanisms microglia use to support neuronal function are likely diverse and differ based on brain region and developmental stage.

Congratulations Patrick and go NGP!

Latest Issue of Opportunities To Explore - May 28-June 1, 2018

Friday, May 25, 2018

The latest issue of Opportunities to Explore is out. Get all the latest updates on events, grants, reading resources and more.

Latest Issue of Opportunities To Explore - May 28-June 1, 2018

Outstanding Dissertations Honored

Wednesday, May 23, 2018

Each year, Arts, Sciences & Engineering and the School of Medicine and Dentistry recognize outstanding research and dissertations by PhD students.

Wishing our graduates well at the 2018 Commencement Dinner

Wednesday, May 23, 2018

The 2018 Ph.D.Commencement Dinner was held at the Daisy Flour Mill. Following introductions from Edith Lord, Senior Associate Dean for Graduate Education and Jennifer Stripay, representing the University of Rochester Alumni Council, Awards were presented to three graduating PhD students:

Vincent du Vigneaud Award: Anthony DiPiazza, Microbiology and Immunology, “Insights into CD4 T Cell-Mediated Immunity to Influenza Viruses.” The award is conferred by the Office of Graduate Education to a graduating student whose thesis is judged superior and unique in potential for stimulating and extending research in the field.

Wallace O. Fenn Award: Benjamin Plog, Pathology, “Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury.” The award is given annually to a graduating student judged to have performed especially meritorious research and who presented a Ph.D. thesis suitable to honor the name of Wallace Fenn, former professor and chair of physiology.

Marvel-Dare F. Nutting Award (recognizing an outstanding Biochemistry PhD): Amber Cutter, whose PhD dissertation was on “Molecular Characterization of Nucleosome Recognition by Linker Histone H1.0.” 

Commencement Dinner Photos

2018 Commencement Dinner

Latest Issue of Opportunities to Explore - May 21-25, 2018

Friday, May 18, 2018

This week holds professional development day, a URBEST Career Story from Sarah Goodwin, PhD and the CIRTL@UR Research Day along with workshops on Strategies for Effective Clinical Teaching and Learning and The Bottom Line: What You Need To Know About Interviewing.

There are many events, opportunities and resources in the latest issue, check it out!

Latest Issue of Opportunities to Explore - May 21-25, 2018

Catching Research Fever: UR CTSI’s Academic Research Track Turns Medical Students into Medical Researchers

Wednesday, May 16, 2018

By Susanne Pritchard Pallo

MSTP Students

The MSTP 2017 incoming class, with former UR CTSI Academic Research Track participants Samuel Weisenthal and Ian De Andrea-Lazarus (far right).

Over the past several decades, concerns have risen about the declining population of physician-scientists, with reports pointing to early career training and support as a possible solution. The UR CTSI Academic Research Track, which allows medical students to try their hands at research, has helped two University of Rochester School of Medicine and Dentistry students take the next step toward a research career: joining an MD-PhD program.  

The pair, Ian De Andrea-Lazarus and Samuel Weisenthal, joined the University of Rochester Medical Scientist Training Program after finishing their Academic Research Track projects. This is a move that a new study from the Association of American Medical Colleges suggests will help them stay in science. The study tracked MD-PhD program graduates over 50 years and showed that most stuck with their research careers. 

Ian and Sam explain what drove them to pursue a career as physician-scientists.

Why did you join the UR CTSI’s Academic Research Track?

Ian: I’ve always craved knowledge and enjoy the challenge of pushing the boundaries of existing human knowledge. I had several years of research experience before applying for medical school - as an undergraduate research assistant in the Linguistics Department at Gallaudet University and as a post-baccalaureate fellow at the National Cancer Institute. For two years, I worked in the Laboratory of Cancer Biology and Genetics at NCI, studying a non-selective cation channel found mainly in the peripheral nervous system that is involved in the transmission and modulation of pain.

Sam: Like Ian, I was inspired by my time as a post-baccalaureate trainee at the NIH, where I worked for a year in a computational radiology lab. I also had a great time doing a summer research project in health informatics at Rochester. I joined the Academic Research Track because I wanted to study the vast amount of data being collected through the electronic health record. In a single year, the University of Rochester Medical Center alone accrues more than two terabytes of non-image data (a lot). I was particularly interested in how this data could be used to predict – and hopefully help prevent – adverse health events in patients. 

How did your experience in the Academic Research Track drive you to join the University of Rochester Medical Scientist Training Program?

Ian: I had originally wanted to apply for the University of Rochester Medical Scientist Training Program but I was afraid that my application would not be competitive enough. The Academic Research Track was the bridge that allowed me to pursue my goal of becoming a physician-scientist and reinvigorated my interest in research. The program allowed me to obtain a master’s degree in Public Health along with the tools and drive I needed to apply for the MD-PhD program.

Sam: I had also previously considered an MD-PhD program, but did not have a cohesive story to tell in an application. The Academic Research Track year allowed me to obtain a master’s degree in Data Science from the Goergen Institute for Data Science at the University of Rochester, which provided a foundation for more advanced study. It also helped me discover the UR CTSI’s Translational Biomedical Science PhD Program, which was a good fit, and to fully engage in a research project in a great lab. 

What did you study during the Academic Research Track program?

Sam: We were initially interested in predicting readmission to the intensive care unit, which is a quality metric used by some hospitals. Ultimately, however, we decided to focus on predicting acute kidney injury, which is common, deadly, and sometimes completely preventable with simple interventions like fluid administration or medication review.  Insights from our studies could be used to hopefully develop a better predictive tool that could help prevent acute kidney injury in the future.

Ian: We explored the association between low levels of lead in the serum of 3- to 5-year-old children and their mental capacity to focus attention, remember instructions, and juggle multiple tasks. We used a well-characterized tool for assessing these mental executive functions in children, called the Stroop day-night task, but found that the tool may not be sensitive enough to detect lead’s effects on neurodevelopment.

What are you studying now?

Sam: I am pursuing a joint degree between the Translational Biomedical Science PhD Program and Computer Science Department, with Computer Science as a minor. This includes select coursework in computer science, biostatistics, and medicine. My research focus is a continuation of my Academic Research Track project with Martin Zand, Ph.D., co-director of the UR CTSI and professor of Nephrology and Public Health Sciences at the University of Rochester Medical Center. Our goal is to improve acute kidney injury prediction by reformulating the standard approach and performing more rigorous error analysis. Ultimately, we hope to squeeze maximal predictive value out of electronic health record data to assist physicians in making the best decisions for at-risk patients.

Ian: I am pursuing a doctoral degree in the UR CTSI’s Translational Biomedical Science PhD Program and working with John Foxe, Ph.D., Killian J. and Caroline F. Schmitt chair of Neuroscience, and Edward Freedman, Ph.D., associate professor of Neuroscience, on a mobile brain/body imaging (MoBI) study. We are interested in understanding how the brains of people with decreased cognitive function, like those with Alzheimer’s disease, handle the cognitive demands of multitasking while walking, which requires continuous processing of information about the environment and body position.

Read More: Catching Research Fever: UR CTSI’s Academic Research Track Turns Medical Students into Medical Researchers

Pharmacology Alumni Named Associate Dean

Friday, May 11, 2018

Jennifer Mathews in front of ACPHS LogoJennifer Mathews, PhD has been named the Associate Dean for the Albany College of Pharmacy and Health Sciences - Vermont Campus.

Dr. Mathews earned her doctorate in Pharmacology from the University of Rochester in 2007, her field(s) of interest as a student were Neuropharmacology, Opioid receptors, Pain, Tolerance, Antinociception

Her responsibilities will include execution of the pharmacy program; supervision of faculty; campus operations; and coordination of the development, implementation, and assessment of initiatives that support the programs on the Vermont Campus, which also include a Master’s program in Pharmaceutical Sciences.

Congratulations to Dr. Mathews!

Read More: Pharmacology Alumni Named Associate Dean

New Issue of Opportunities to Explore - May 14-18, 2018

Thursday, May 10, 2018

This week features a webinar on renting in New York City, the Graduate Student Society (GSS) Coffee Hour, a CV/Resume workshop and the 5th Annual Alumni Networking Event, the work week ends with the Pre-doctoral Organization for the Neurosciences (PONS) Luncheon Roundtable Series and the weekend brings commencement for Doctoral and Master Degree Students. Congratulations to all of our graduates!

Opportunities to Explore has Events and Grant, Travel Award, and Conference Information into June and beyond!

New Issue of Opportunities to Explore - May 14-18, 2018

Deborah Cory-Slechta Receives Lifetime Achievement Award in Graduate Education

Monday, May 7, 2018

As a faculty member at the School of Medicine and Dentistry, Deborah Cory-Slechta holds professorship positions in the departments of Environmental Medicine, Pediatrics, and Public Health Sciences. A former chair of the Department of Environmental Medicine and principal investigator of the department’s National Institute of Environmental Health Sciences Center, Cory-Slechta has been nationally and internationally recognized for her scientific contributions.

Considered one of the medical school’s most distinguished faculty members, Cory-Slechta served in leadership roles for several Ph.D. programs, where she also teaches key graduate courses. As the recipient of a Women’s Health and the Environment over the Entire Lifespan grant, she oversees a career development and mentoring initiative for junior faculty members.

Widely regarded for her research on the consequences of developmental exposures to environmental chemicals on brain development and behavior, she has examined the effects of exposures to metals, pesticides and air pollutants. That work—particularly her groundbreaking research on the biological effects of exposure to lead—has had important regulatory and policy implications.

After earning her undergraduate and master’s degree at Western Michigan University, she received her PhD at the University of Minnesota. Following a postdoctoral fellowship at Rochester, she joined the University in 1982.

Read More: Deborah Cory-Slechta Receives Lifetime Achievement Award in Graduate Education

Students Present 'Groundbreaking and Transformative' Research at Expo

Friday, May 4, 2018

At the annual Undergraduate Research Exposition, students presented projects on topics ranging from fluid dynamics, deforestation in Bolivia, and nomad cultures in Morocco, to prenatal depression, meteorites, and software that affects education. President’s Award winners Lauren Oey ’18 (left), Harrah Newman ’18, Yiyun Huang ’18, and Perry DeMarche ’18 were among the students honored at the event.

Pathology Graduate, Ben Plog, Ph.D., Receives 2018 Fenn Award

Wednesday, May 2, 2018

Ben PlogBen Plog, Ph.D. has been named the recipient of the distinguished Wallace O. Fenn Award. Named after the late University Physiology professor and chair, the award is given to a graduating student whose Ph.D. research and thesis honor the name and work of Dr. Fenn.

Plog was a medical science training program (MSTP) student who entered the Pathology graduate program in 2012 to work in the lab of Maiken Nedergaard, M.D., D.M.Sc. in the Center for Translational Neuromedicine and Neurosurgery. Having defended his thesis (titled Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury), Plog has returned to Medical School to continue his Medical School training and will be part of 2018 Ph.D. degree conferral.

Latest Rochester Medicine Explores the 'Spirit and Science' of Lynne Maquat

Tuesday, May 1, 2018

maquat

The magazine's new issue, now in an interactive, flip-book format, highlights the investigative work of the J. Lowell Orbison Endowed Chair, as well as the impressive efforts of our medical students, alumni and faculty—past and present.

Read More: Latest Rochester Medicine Explores the 'Spirit and Science' of Lynne Maquat

Neuroscience Graduate Student publishes paper with the Briggs lab

Friday, April 27, 2018

Neuroscience Graduate student Allison Murphy co-authored a paper with the Briggs lab while in a rotation with the lab.  Allison contributed an extensive amount of work toward the paper during her fall rotation, and the paper was accepted shortly after her joining the lab.

Postdoctoral fellow, Mike Hasse was the first author on the paper, "Morphological heterogeneity among corticogeniculate neurons in ferrets: quantification and comparison with a previous report in macaque monkeys."

Nice work Allison and Mike!!

Read More: Neuroscience Graduate Student publishes paper with the Briggs lab

The Center for the Integration of Research, Teaching and Learning (CIRTL) Events

Wednesday, April 25, 2018

One of the many sponsored programs within the Center for Professional Development in the School of Medicine & Dentistry is The Center for the Integration of Research, Teaching and Learning (CIRTL). CIRTL is an NSF-funded consortium of 42 PhD granting institutions around the country, whose aim it is to advance the teaching of STEM disciplines in higher education by preparing future faculty. CIRTL uses graduate and postdoc level research trainees as the leverage point to develop national Science, Technology, Engineering, and Mathematics (STEM) faculty committed to implementing and advancing effective teaching practices for diverse student audiences as part of successful professional careers. The goal of CIRTL is to improve the STEM learning of all students at every college and university, and thereby to increase the diversity in STEM fields and the STEM literacy of the nation.

CIRTL provides a number of online workshops, courses, and educational experiences throughout the year. Graduate students and postdocs interested in teaching are encouraged to participate in CIRTL events. For more information about CIRTL, please visit rochester.edu/college/cetl/cirtl/.

Upcoming CIRTL Events Include…

Center for the Integration of Research, Teaching and Learning (CIRTL) @ UR Research Day

Wednesday, May 23 | 9:00 am-5:00 pm | River Campus

Center for the Integration of Research, Teaching and Learning (CIRTL) @ UR will be hosting its annual Research Day and all trainees interested in participating are invited to attend. Kevin Kelly’s LinkedIn profile provides an overview of his work in eLearning. The day’s agenda will include examining teaching through a research lens, optimizing course design, using technology to assess learning in the classroom, using technology to engage diverse learners, and using technology to share course content.  Register for this event. Trainees with an interest in teaching are highly encouraged to attend. For a full overview of the days agenda and workshop descriptions, please contact Dr. Jenny Hadingham at jennifer.hadingham@rochester.edu or (585) 276-5998.

The Bugs in Your Gut Could Make You Weak in the Knees

Tuesday, April 24, 2018

A Prebiotic May Alter the Obese Microbiome and Protect Against Osteoarthritis

Diagram showing the gut microbiome of a person who is obese and has osteoarthritis of several major

The obese microbiome may be a

key driver of osteoarthritis and a

prebiotic supplement may turn

things around.

Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

Osteoarthritis, a common side effect of obesity, is the greatest cause of disability in the US, affecting 31 million people. Sometimes called “wear and tear” arthritis, osteoarthritis in people who are obese was long assumed to simply be a consequence of undue stress on joints. But researchers at the University of Rochester Medical Center provide the first evidence that bacteria in the gut – governed by diet – could be the key driving force behind osteoarthritis.   

The scientists found that obese mice had more harmful bacteria in their guts compared to lean mice, which caused inflammation throughout their bodies, leading to very rapid joint deterioration. While a common prebiotic supplement did not help the mice shed weight, it completely reversed the other symptoms, making the guts and joints of obese mice indistinguishable from lean mice.

Read Full Article

Brandon Berry Recipient of a two-year American Heart Association Predoctoral Fellowship & Professional Member of the AHA July 1, 2018 – June 30, 2020

Monday, April 23, 2018

Brandon Berry, graduate student in the laboratory of Dr. Andrew P. Wojtovich was awarded a two-year American Heart Association Predoctoral Fellowship entitled, “Optogenetic Control of Mitochondrial Function to Protect Against Ischemia Reperfusion Injury”.

Project Summary

Mitochondria are central mediators of cell death following the pathologic stress of ischemia reperfusion (IR) injury during heart attack or stroke. However, mitochondria can be targeted with specific interventions that inhibit cell death following IR. The mitochondrial protonmotive force (PMF) is coupled to ATP synthesis, and controls ion gradients and oxidative stress. Dissipation of the PMF in IR injury results in cellular damage and death. Interestingly, mild uncoupling of the PMF from ATP synthesis using low-dose protonophores protects against IR injury. It is unclear whether uncoupling triggers protective signaling, or if uncoupling itself is the effector of protection. Further, pharmacologic tools lack temporal and spatial control, obscuring when and where uncoupling is sufficient to protect against IR injury. Uncoupling mitochondria using optogenetics addresses the spatiotemporal challenge of using protonophores. Spatiotemporal control can determine if the mechanism of uncoupling confers protection before ischemia (preconditioning), during ischemia, during reperfusion, or after reperfusion (postconditioning). Overall, using our novel optogenetic tools, this project aims to test how precise, selective, reversible uncoupling is sufficient to elicit cellular responses that protect against IR injury.

Neuroscience Graduate Student Receives American Heart Association Pre-Doctoral Fellowship

Monday, April 23, 2018

Kathleen Gates

Kathleen Gates has been awarded an American Heart Association Predoctoral Fellowship.  This fellowship is meant to enhance the integrated research and clinical training of promising students who are matriculated in pre-doctoral or clinical health professional degree training programs and who intend careers as scientists, physician-scientists or other clinician-scientists, or related careers aimed at improving global cardiovascular health.

Congratulations Kathleen!!

April 23rd - Genetics Day 30th Annual Scientific Symposium

Friday, April 20, 2018

Dr. EisenMark your calendars for the 30th annual Genetics Day!  The 16th annual Fred Sherman Lecture will be delivered by Michael Eisen, PhD, from Berkeley University.  You and your colleagues are invited to submit your posters for the Genetics Day poster session to be held 12:00 – 2:00pm on Monday, April 23, 2018.  Cash prizes will be awarded to select graduate student and postdoc posters.

New Fellowship Opportunity: TRIUMPH Post-doctoral Fellowship - MD Anderson Center

Wednesday, April 18, 2018

TRIUMPH (Translational Research In Multidisciplinary Program) Post-doctoral Fellowship

The Cancer Prevention & Research Institute of Texas (CPRIT) TRIUMPH Postdoctoral Fellowship Program is a post-doctoral program providing unique training in clinical and translational research. The immediate goal of our program is to recruit talented, productive, well-trained PhDs and train them through didactic course work as well as clinical rotations and a unique mentorship to pursue clinical and/or translational research. A long-term goal of this program is to produce scientists who can be paired with suitable physician scientists to co-PI a research laboratory.

This is a three-year training program. First year postdoctoral fellows participate in a series of didactic clinical course work offered at the MD Anderson UTHealth Graduate School (GSBS), MD Anderson Cancer Center, or the UTHealth McGovern School of Medicine and strategically matched clinical rotations, while pursuing research in a basic or translational research laboratory. Second and third year fellows are co-mentored by a basic science/translational scientist mentor and a physician/clinical scientist mentor on clinical/translational research projects. The TRIUMPH postdoc will obtain a certificate upon successful completion of the program. The expectation for our post-docs is that by the end of their 3-year training, they will have first authored at least 2 papers in high impact journals. Our multidisciplinary training program will award a certificate upon completion.

Please visit the TRIUMPH website for additional information

Thesis competition winner describes protein translation in 3 minutes or less

Wednesday, April 18, 2018

Jillian Ramos showed exactly how to capture an audience’s attention – and hold it – at the University of Rochester’s third annual Three Minute Thesis Competition finals.

As a result, the PhD student in assistant professor Dragony Fu’s biology lab walked away with not only the $750 first place prize awarded by a panel of faculty judges, but the $250 people’s choice prize awarded by an audience that filled all but a few seats in the Class of ’62 Auditorium.

Read The Full Article

Opportunities to Explore - April 16-20, 2018

Monday, April 16, 2018

New Issue of OTE is out!

This Wednesday sees a webinar for Genomic Research and the Million Veteran Program on Wednesday, along with the Graduate Student Society Coffee Hour and a All-Network Teaching-as-Research Presentations workshop.

Thursday sees the Graduate Women In Science (GWIS) Monthly Meeting: Science Co-Parenting: Raising a Family and a Lab at the Same Time.

A campus wide Undergraduate Research Exposition arrives on Friday along with the UP-STAT 2018 Conference which is a two day event going into the weekend.

The New Issue has opportunities and events going till the end of May!

New Issue Of Opportunities to Explore - April 16-20, 2018

Eight Finalists Confirmed for Three Minute Thesis Competition

Friday, April 6, 2018

Communicating research with three minutes and a slide

At a time when it is more important than ever for scientists to communicate clearly with the public, eight University PhD students and postdocs will do their best to summarize their research with just three minutes and a slide.

They are finalists in the University’s annual Three Minute Thesis competition, which will be held at 4 p.m., next Thursday, April 12, in the Class of ’62 Auditorium at the Medical Center.

A total of 44 students initially entered the competition, which was founded at University of Queensland, and is now in its third year at Rochester. The eight finalists are:

The winner will receive a $750 research travel award. There are also $500 and $200 research travel awards, respectively, for the runner-up and the people’s choice winner.

Read More: Eight Finalists Confirmed for Three Minute Thesis Competition

Latest Issue of Opportunities To Explore - April 9-13, 2018

Friday, April 6, 2018

It's an event-filled week at the University of Rochester!

The Transgender Health and Wellness 2018 Conference is on Monday along with the online workshop: I Completed My IDP…Now What?

Wednesday brings a workshop on Online Learning at The School of Medicine and Dentistry and the Monthly Postdoctoral Association meeting.

Thursday sees the Online Teaching workshop move to LeChase Hall on River Campus, there is also an online program covering Inclusive Teaching in Science. The Three Minute Thesis final rounds out Thursday in the Class of '62 Auditorium.

Friday brings the 2018 Diversity Conference and workshops on Open Education and making the most of your post-graduate experience.

So much to do just next week, for even more events see the current issue of Opportunities to Explore

Latest Issue of Opportunities to Explore

New Issue of Opportunities to Explore - April 2-6, 2018

Friday, March 30, 2018

This week URBEST Official opens enrollment, running from April 1 to April 15, in addition URBEST hosts Kavita Berger in telling her career story and finishes the week with the Grand Gesture 

Other events this week include a free online estimated tax workshop, the Gwen M. Green Center offers workshops on obtaining security clearance and renting in NYC. Finally there is a PFCC workshop "The C.A.R.E Effect Movement: The Naked Truth about Compassion is Revealed".

That is just this week. The OTE provides information, resources and events throughout the month of April.

Read The Latest Issue Of Opportunities to Explore

McMurray Named Associate Director of Pathology Graduate Program

Wednesday, March 28, 2018

Helene McMurrayHelene McMurray, Ph.D., has been named the new associate director of the Cell Biology of Disease (Pathology) Graduate Program at the University of Rochester, which became effective in March.

Dr. McMurray is a clinical assistant professor with a primary appointment in Pathology and Laboratory Medicine. She currently serves as the Director-in-Training in the Tissue Typing/Histocompatibility Laboratory at Strong Memorial Hospital.

Her research collaborations with scientists in the Department of Biomedical Genetics focus on identification of vulnerabilities in cancer cells, and utilize approaches in genomics, bioinformatics, biostatistics, and genetics. As an educator, Dr. McMurray works to introduce students to these modern techniques in biomedicine.

Dr. McMurray will join Dr. Richard Libby (Opthalmology) who directs the program.

“Mentors and advisors have helped me imagine new possibilities in my science and in my career," said McMurray. "I wouldn’t be who or where I am today without guidance from others. I am excited to take on this new role in the Cell Biology of Disease Graduate Program to try to share what I have learned with the next generation of scientists.”

Alumni Spotlight on Dana Olzenak, PhD ‘15

Monday, March 26, 2018

Dana Olzenak McGuire, who graduated with a PhD in Epidemiology from the 2015 class was recently appointed to the role of public health director in St. Lawrence County. As public health director, Dr. Olzenak McGuire supervises about 30 employees including nurses, the county coroners and administrative staff.

Dr. Olzenak McGuire brings a wide range of disciplines into the new role with degrees in Physical therapy, an MBA and the PhD in Epidemiology.

Visit our Epidemiology PhD Program to learn more. Congratulations Dana!

"Epidemiology just sounded really interesting to me, It covers all diseases from environmental to infectious to chronic." - Dana Olzenak McGuire

Read More: Alumni Spotlight on Dana Olzenak, PhD ‘15

New Issue of Opportunities to Explore - March 26-30, 2018

Saturday, March 24, 2018

This week Opportunities to Explore shares news about the Meliora Collective, which will serve as a student and alumni network for collaboration. There is a virtual career fair, The Graduate Student Society coffee hour, a workshop on Connecting with Learners in Digital Classrooms and Meeting Spaces, a free webinar on Making the Most of Your Ph.D. or Postdoc and a workshop on startups.

The week is rounded out by the three minute thesis sub heats and a PONS luncheon roundtable.

That's just this week, OTE has events and opportunities heading into April/May. Check out the latest issue!

Opportunities to Explore - March 12-16, 2018

Monday, March 12, 2018

The latest issue of Opportunities is out now.

This week, Three Minute Thesis (3MT) Competition Registration opens, Graduate Women in Science and the Postdoctoral Association hold their monthly meetings and the week is rounded out with an F-Series and Grant Writing Workshop.

For all this weeks events and events heading into April/May 2018, read the latest issue!

Opportunities to Explore - March 12-16, 2018

Leader in the field of epigenetic regulation and cancer biology joins the Department of Biomedical Genetics and GDSC Program

Wednesday, March 7, 2018

Dr. Paula VertinoDr. Paula Vertino, currently the leader of the Cancer Genetics and Epigenetics Program at Emory University will be joining the University of Rochester Department in Biomedical Genetics and the Wilmot Cancer Institute this summer. Dr. Vertino's research on cancer epigenetics will greatly expand our areas of research strengths. She is an exceptionally important player in her field, and we look forward to welcoming her to the GDSC program!

Read More: Leader in the field of epigenetic regulation and cancer biology joins the Department of Biomedical Genetics and GDSC Program

Cindy Wang Wins America’s Got Regulatory Science Talent Competition

Monday, March 5, 2018

Cindy WangXiaowen (Cindy) Wang, M.S., a graduate student in the Cellular and Molecular Pharmacology and Physiology PhD Program placed first in the 5th annual "America’s Got Regulatory Science Talent" competition for  her proposal “Dr. Data: An Integrated Drug Repurposing Database for Identifying New Indications of FDA Approved Drugs”

To read more about Cindy’s proposal and the competition, please visit the CTSI Stories website.

Congratulations Cindy!

New Issue of Opportunities to Explore - March 5-9, 2018

Friday, March 2, 2018

A new issue of Opportunities to Explore is out!

This week a workshop on encouraging learner interaction starts the week along with a Pre-Application webinar for T32 grants. Tuesday sees a career story with Michael Brady, PhD and a China Career Expo.There are tax related events rounding out the week for students and postdocs. 

And that's just this week, we have events heading into the end of April.

Opportunities to Explore - March 5-9, 2018

New Issue of Opportunities to Explore - February 26-March 2, 2018

Friday, February 23, 2018

This week CIRTL hosts an online learning in blackboard: Understanding Diversity and Inclusive Teaching in the Community College Environment, The Graduate Student Society holds its coffee hour. There is a webinar on how to ace interviews. The first Graduate Student, Trainee, & Alumni Networking Night is on Wednesday. The work week ends with the URBEST Grand Gesture event, a conflict management workshop and Acro-yoga & Stress Relief w/ Joanne Wu, MD

That's just this week! This issue provides you with things to attend well into April.

Latest Issue of Opportunities to Explore - February 26-March 2, 2018

Janelle Veazey Receives F31 National Research Service Award From NIH

Sunday, February 18, 2018

Immunology graduate student Janelle Veazey, has received an F31 National Research Service Award from the NIH. This pre-doctoral fellowship will support her research investigating a new role for airway epithelial protein kinase D in anti-viral immunity.

Congratulations Janelle!

New Issue of Opportunities to Explore - February 12-16, 2018

Friday, February 9, 2018

This week there is a workshop on Navigating a career fair/expo, the PDA monthly meeting, a career expo on river campus and workshops from Future Faculty, CIRTL and GWIS. The week ends with a PONS luncheon and a Thinkers and Drinkers meeting

Looking further ahead, Stephen Tajc provides a look at his career in URBEST's series. Workshops on job descriptions and handling difficult conversations are available and CIRTL provides several events throughout the month. All this and more in the latest issue of OTE!

Latest Issue of Opportunities to Explore - February 12-16, 2018

New Edition of Opportunities to Explore - February 5-9, 2018

Monday, February 5, 2018

This weeks events in opportunities to explore there is a career event for postdocs, a faculty development workshop about teaching and learning in a digital age, a career story by Teresa Long and information on leveraging linked in. The week is rounded out by the second interview weekend at SMD and the PDA winter social.

Take a look at the weeks events and even more events further out in the latest issue

Opportunities to Explore, February 5-9, 2018

E-Cigarette Flavors Are Toxic to White Blood Cells, Warn Scientists

Thursday, February 1, 2018

A new study led by the Rahman lab and first author, Toxicology post-doctoral researcher, Dr. Thivanka Muthumalage, adds to growing evidence on the harmful health effects of e-cigarettes. Currently, the article has been viewed over 16,500 times (in just one day) and several news sources have written articles and reported about it across the globe.

The paper has been so well received that it is currently ranked in the top 5% of all research outputs ever tracked by Altmetric.

The study has revealed another potential health risk of e-cigarettes, finding that the chemicals used to flavour e-cigarette liquids are toxic to white blood cells. The study wanted to test the assumption that nicotine-free flavoured e-liquids are safer than smoking tobacco cigarettes, looking at what effect e-cigs might have on the immune system.

To do this the researchers directly exposed a type of white blood cell called monocytes, which help the body fight infection, to e-liquids. They found that e-cigarette flavoring chemicals and liquids can cause significant inflammation to monocytes, with many of the flavouring chemicals also causing significant cell death. Some flavours were found to be more harmful than others, with cinnamon, vanilla, and buttery flavours among the worst.

The researchers also found that mixing e-cigarette flavours has a much worse effect than exposure to just one flavour and caused the most toxicity to white blood cells.

The study's first author, Dr. Thivanka Muthumalage, commented on the findings, saying that although these flavouring compounds may be safe for ingestion, the results show they are not safe for inhalation and add to a growing body of evidence suggesting that e-cigarettes are harmful to health. Previous research has also found that the flavors used in e-cigarettes cause inflammatory and oxidative stress responses in lung cells.

Senior author Dr. Irfan Rahman expressed concern: “Our scientific findings show that e-liquid flavors can, and should, be regulated and that e-juice bottles must have a descriptive listing of all ingredients. We urge regulatory agencies to act to protect public health,” he said, also warning that, “alluring flavour names, such as candy, cake, cinnamon roll and mystery mix, attract young vapers.”

The team are now planning further research and are calling for further long-term human studies to understand better the harmful effects of e-cigarettes. The findings can be found published online in the journal Frontiers in Physiology.

To learn more please read the following articles:

Lungs Mays Hold Key to Thwarting Brain Damage after a Stroke

Wednesday, January 31, 2018

By Mark Michaud

The harm caused by a stroke can be exacerbated when immune cells rush to the brain an inadvertently make the situation worse. Researchers at the University of Rochester Medical Center (URMC) are studying new ways to head off this second wave of brain damage by using the lungs to moderate the immune system’s response.

“It has become increasingly clear that lungs serve as an important regulator of the body’s immune system and could serve as a target for therapies that can mitigate the secondary damage that occurs in stroke,” said URMC neurologist Marc Halterman, M.D., Ph.D. “We are exploring a number of drugs that could help suppress the immune response during these non-infection events and provide protection to the brain and other organs.”

Halterman’s lab, which is part of the Center for NeuroTherapeutics Discovery, has been investigating domino effect that occurs after cardiac arrest. When blood circulation is interrupted, the integrity of our intestines becomes compromised, releasing bacteria that reside in the gut into the blood stream. This prompts a massive immune response which can cause systemic inflammation, making a bad situation worse.

While looking at mouse models of stroke, his lab observed that a similar phenomenon occurs. During a stroke blood vessels in the brain leak and the proteins that comprise the wreckage of damaged neurons and glia cells in the brain make their way into blood stream. The immune system, which is not used to seeing these proteins in circulation, responds to these damage-associated molecular patterns and ramps up to respond. Mobilized immune cells make their way into the brain and, finding no infection, nevertheless trigger inflammation and attack healthy tissue, compounding the damage.

The culprit in this system-wide immune response is neutrophils, a white cell in the blood system that serves as the shock troops of the body’s immune system. Because our entire blood supply constantly circulates through the lungs, the organ serves as an important way station for neutrophils. It is here that the cells are often primed and instructed to go search for new infections. The activated neutrophils can also cause inflammation in the lungs, which Halterman suspects may be mistakenly identified as post-stroke pneumonia. The damage caused by activated neutrophils can also spread to other organs including the kidneys, and liver.

Read More: Lungs Mays Hold Key to Thwarting Brain Damage after a Stroke

Andrew Cox Receives US Patent

Tuesday, January 30, 2018

Cox

Andrew Cox

MD/PhD student, Andrew Cox has been awarded a patent, "Attenuated Influenza Vaccines and Uses Thereof" (9,787,032), for a new live flu vaccine that is safer than the current one so should permit higher dose administration to overcome the current problems with the live vaccine.

When not in medical school, Andrew is currently pursuing his degree in the Dewhurst lab, working on temperature sensitivity of Influenza polymerase as a determinant of pathogenicity.

Congratulations Andrew!

Inaugural Winners of the CPD Travel Award

Thursday, January 25, 2018

The Center for Professional Development (CPD) is excited to announce this year’s winners of the CPD Travel Award.  Congratulations to Valeriia Sherina, PhD student in Statistics and Cui Li, postdoctoral appointee in the Center for Translational Neuromedicine, for winning the inaugural CPD Travel Award!  CPD would like to thank all the PhD students and postdoctoral appointees who submitted applications. Applications for the 2018-2019 academic year will be available in early spring.  

Award Information

The Center of Professional Development (CPD) is sponsoring a CPD Travel Award for PhD students and postdoctoral appointees in the School of Medicine and Dentistry. Each travel award is worth up to $1500 and can be utilized for travel to a conference or for a professional development opportunity relevant to preparation for current or future career endeavors. 

New Issue of Opportunities to Explore

Thursday, January 25, 2018

This week in Opportunities to Explore there is the future faculty workshop, a benefit play for humans for education, the grand gesture with URBEST and finally the Graduate Student Society Gala, being held at the Hilton Garden Inn.

Looking further out, there are workshops on online teaching, linked in, help with career fairs and more. Teresa Long, MS will be sharing her career story. There are employment opportunities, conferences and programs to apply/register for.

New Issue of Opportunities to Explore – January 29-February 2, 2018

New Issue of Opportunities to Explore – January 22-January 26, 2018

Friday, January 19, 2018

The latest issue of Opportunities to Explore is out!

This issue of OTE is packed with events. There are workshops for investing and Job searches, with a anti human trafficking conference rounding out the week. further into the issue you will find information on career focused events, teaching, research, mentoring and more!

Check out new employment opportunities available at AMRI and Cardiocore.

New Issue of Opportunities to Explore – January 22-January 26, 2018

New Issue of Opportunities to Explore – January 15-January 19, 2018

Friday, January 12, 2018

The latest issue of Opportunities to Explore is out!

The first of two SMD Interview Weekends starts on Thursday, January 18th.

SMD graduate students and postdoctoral associates are invited to attend a special guest day for the University of Rochester’s Toastmasters Club, Daybreakers, on Thursday, January 18th.

Check out new employment opportunities available in Western New York at AMRI.

New Issue of Opportunities to Explore – January 15-January 19, 2018

The Art of Science: Grad Student Finds Inspiration in Images of the Brain

Friday, January 12, 2018

Stowell Brain Painting

The complex biology, networks, and symphony of signals that underlie human cognition are a font of endless mystery and wonder to those who study it.  For Rianne Stowell, a graduate student in the lab of URMC neuroscientist Ania Majewska, Ph.D., these questions are also a source of artistic inspiration which has led to the creation of striking paintings of the brain’s inner workings.

Stowell’s most recent creation (above) is based on research which has recently been published in the journal Developmental Neurobiology and sheds new light on the role that immune cells called microglia play in wiring and rewiring the connections between nerve cells.

Stowell recalls wanting to pursue a career in art as far back as elementary school in Pennsylvania and while she carried that desire with her to Moravian College, she also began to explore other academic fields. Her interest in biology and psychology attracted her to a degree in neuroscience and that decision ultimately led her to the University of Rochester School of Medicine and Dentistry, where she is in now in her fourth year of graduate studies in pursuit of her Ph.D. in neuroscience.

Read More: The Art of Science: Grad Student Finds Inspiration in Images of the Brain

New Issue of Opportunities to Explore – January 8-January 12, 2018

Friday, January 5, 2018

The latest issue of Opportunities to Explore is out!

The Undergraduate Placement Program is seeing graduate and postdoctoral associates to serve as mentors to undergraduate students focusing on health and life sciences.

Graduate Women in Science GWIS will be hosting a presentation entitled “Tales from the Other Side: My Experience working in Industry” by Melanie Preston, Ph.D., SMD graduate of 2009 and postdoctoral associate from 2009-2010.

New Issue of Opportunities to Explore – January 8-January 12, 2018

New Issue of Opportunities to Explore – January 1-January 5, 2018

Friday, December 29, 2017

The latest issue of Opportunities to Explore is out!

Registration for Leadership and Management for Scientists, IND 439 is still available. This course is designed for graduate students and postdoctoral appointees who wish to enhance their leadership and management skills. It will cover a range of topics, including project management, communication, personality styles and budgeting skills, to help this unique group of leaders and managers.

The Center for Professional Development hosts workshop on LinkedIn entitled “Utilizing LinkedIn to Market Yourself in Today’s Job Search Environment” on Friday, January 12th from 2:00pm - 4:00 pm.

New Issue of Opportunities to Explore – January 1-January 5, 2018

New Issue of Opportunities to Explore – December 4-December 8, 2017

Friday, December 1, 2017

The latest issue of Opportunities to Explore is out!

We want your employer referrals! Let us know what employers you would like us to reach out to gain additional information about the company/organization, post internship and employment opportunities, and invite to campus for recruitment and interview events.

Free online webinar entitled How to Have a Great Interview! The webinar will help participants to develop the critical skills necessary to excel at an interview and provide a complete overview of the interview process, from preparation to execution, including often-used questions and answers.

New Issue of Opportunities to Explore – December 4-8, 2017

New Issue of Opportunities to Explore – November 27-December 1, 2017

Tuesday, November 28, 2017

The latest issue of Opportunities to Explore is out!

Deadline for the Teaching-as-Research (TAR) Fellowship and is Friday, December 1, 2017.

Check out the CPD’s Lending Library catalog to see free professional development books and resources you can sign out and utilize. To borrow a book, stop by our office in G-9627 or email us with your request.

New Issue of Opportunities to Explore – November 27-December 1, 2017

New Issue of Opportunities to Explore - October 30-November 3, 2017

Tuesday, October 31, 2017

The latest issue of Opportunities to Explore is out!

Interested in learning more about employment within industry? Kurt Schilling, PhD will be here to share his career story and discuss what he does as senior vice-president of Basic Research and Advanced Technologies at The Estée Launders Companies, Inc.

Applications are now open for the Teaching-as-Research (TAR) Fellowship and will be accepted until Friday, December 1, 2017.

Opportunities to Explore - October 30th - November 3rd

Navigating Career Choices advises current trainees on postgraduate options

Monday, October 23, 2017

Jennifer Stripay, PhD and Ryan Dawes, PhD

Jennifer Stripay, PhD and Ryan Dawes, PhD

The Center for Professional Development recently invited Neuroscience graduates Jennifer Stripay, PhD ’16 and Ryan Dawes, PhD ’16 to discuss their personal experience with navigating career choices and locating employment post-graduation. Their presentation was entitled “Navigating Career Choices” and had over 30 participants from various programs throughout the School of Medicine and Dentistry in attendance. The workshop provided participants with advice on networking, the application process, interviewing and negotiating tips. Following the workshop, participants were invited to utilize skills learned from the workshop to network one-on-one with Jennifer and Ryan in the Forbes Mezzanine. The Graduate Education & Postdoctoral Affairs Office and CPD would like to thank the SMD Advancement Team for helping to co-sponsor this event!

New Issue of Opportunities to Explore

Monday, October 23, 2017

The latest issue of Opportunities to Explore is out!

This week there are many career related resources including a CV writing workshop and a job search support group

Later on this month there are events about negotiation, health insurance for postdocs, and online and virtual career fairs. All this and more can be found inside!

Opportunities to Explore - October 23rd - October 27th

Emma Grygotis wins Outstanding Student Mentor Award

Friday, October 20, 2017

Emma Grygotis

Emma Grygotis, a student in the Cellular and Molecular Pharmacology and Physiology PhD Program was selected by SMD faculty to be this year’s recipient of the Outstanding Student Mentor Award. Her selection was based on her contributions to mentoring, leadership, science advocacy, and community outreach.

Emma is currently working in the laboratory of Dr. Denise Hocking, whose laboratory research focuses on understanding the mechanisms by which the extracellular matrix protein, fibronectin, affects cell and tissue functions that are critical for wound repair. Emma's thesis project specifically investigates the mechanisms by which the structure and function of extracellular matrix proteins collagen and fibronectin can be altered by ultrasound for tissue engineering applications.

The award was presented to Emma at the School of Medicine and Dentistry Convocation Ceremony, along with a monetary prize of $500.

Neurology & Neuroscience Panel Advises Prospective Trainees

Wednesday, October 18, 2017

On Tuesday, October 17, 2017, PONS teamed up with the BCS & Neuroscience Undergraduate Council (BNUC), SIGN, and NSFG to host a Graduate/Medical Student Panel for those interested in pursuing an advanced degree in Neuroscience or Neurology.

About 20 undergraduate attendees asked questions of our panel of Neuroscience PhD, MD/PhD, and Neurology MD students currently enrolled at the University of Rochester’s School of Medicine and Dentistry.  Our panelists included 2nd Year NGP PhD students Emily Warner and Neal Shah, 1st Year NGP MD/PhD student Karl Foley, and 1st Year MD student Josh Geiger.  BNUC Co-President Herman Li and PONS President Holly Beaulac moderated the event.

Each panelist shared their individual journeys including performing undergraduate research, job shadowing/internships, and teaching/outreach opportunities.  Topics discussed included strategies for determining the right program for one's interests, standing out as an applicant during admissions/interviews, and being productive while limiting stress when acquiring an advanced degree.  We want to thank all of our panelists and attendees for a great turnout and lively discourse!

For more information on upcoming Neuro-events, please visit our homepage

SMD Postdocs Recognized by Steadman Family Postdoctoral Associate Prize in Interdisciplinary Research.

Wednesday, October 18, 2017

Kevin Mazurek, a postdoctoral fellow in the lab of Marc Schieber, professor of neurology, described how the lab is making progress in doing just that when he finished in first place and took the audience prize as well in the Meliora Weekend competition for the Steadman Family Postdoctoral Associate Prize in Interdisciplinary Research.

Mazurek’s prizes were worth $1,250.

Second place went to Jeff Tithof of mechanical engineering, and third place to Po-Ju Lin of the PEAK Human Performance Laboratory at the Wilmot Cancer Institute.

Read More: SMD Postdocs Recognized by Steadman Family Postdoctoral Associate Prize in Interdisciplinary Research.

New Issue of Opportunities to Explore - October 16-20, 2017

Monday, October 16, 2017

The Week of Undergraduate research day is here! But before you get to that always awesome event on Friday, make sure you check out the other events happening this week and fill up your calendar with all the other things we have planned, by taking a look at the latest issue of Opportunities to Explore!

Opportunities to Explore - October 16th - October 20th

Center for Oral Biology Lands Third Training Grant from NIDCR

Wednesday, October 11, 2017

The Center for Oral Biology within UR Medicine’s Eastman Institute for Oral Health has been awarded $2.9 million to expand its renowned training program for oral biologists and dentist-scientists. This award includes Research Training and Research Education grants from the National Institute for Dental and Craniofacial Research, part of the National Institutes of Health.

Read More: Center for Oral Biology Lands Third Training Grant from NIDCR

First Translational Biomedical Science (TBS) Retreat

Tuesday, October 10, 2017

Graduate Education and Postdoctoral Affairs Facebook

New Issue of Opportunities to Explore - October 9-13, 2017

Friday, October 6, 2017

The latest Opportunities to Explore are available! Feel free to browse the numerous events we have coming up for Graduate Students and Postdocs...

October 9-13 Issue of Opportunities To Explore

New Issue of Opportunities to Explore - October 2-6, 2017

Friday, September 29, 2017

The latest Opportunities to Explore are available! Feel free to browse the numerous events we have coming up for Graduate Students and Postdocs...

October 2-6 Issue of Opportunities To Explore

Biochemistry & Biophysics students Mukta Palshikar, Erica VanderWal, and Brandon Davis receive awards at UR School of Medicine Opening Convocation

Friday, September 22, 2017

Congratulations to first year students who received awards at the SMD Opening Convocation on September 12, 2017.

Mutka Palshikar, a first year student in the Biophysics, Structural and Computational Biology program won the Graduate Alumni Fellowship, which recognizes an incoming student with promise for exceptional accomplishment in graduate study.

Arica VanderWal, a first year student in the Biochemistry and Molecular Biology program was awarded the Elmer Stotz Fellowship in Biochemistry, which recognizes the meritorious academic and research accomplishments of an incoming graduate student in the BMB program.

Brandon Davis, an incoming student in the Biochemistry and Molecular Biology program, was a recipient of a Robert L. and Mary L. Sproull University Fellowship, which recognizes the exceptional academic record and research talent of selected students in the first year class University-wide.

Congratulations again to Mutka, Arica, and Brandon!

Palshikar

Mutka Palshikar

VanderWal

Arica VanderWal

Davis

Brandon Davis

New Issue of Opportunities to Explore - September 25-29, 2017

Friday, September 22, 2017

The newest issue of Opportunities to explore is out!

As we head into Fall, we have the following items in this issue(and these events are just THIS Week!)

  • New UR BEST Career Story and Workshop
  • New Career events on entrepreneurship and recruitment
  • 7th Annual Bioethics lecture

...and so much more!

Read About The Latest Opportunities To Explore

NGP Students Earn 2017 Convocation Awards

Thursday, September 21, 2017

Four Neuroscience Graduate Program first year students were presented with Convocation 2017 Awards.

  • Katherine Andersh was the recipient of the Irving L. Spar Award
  • Karl Foley received the Walle J.H. Nauta Award for Excellence in the Neurosciences
  • Berke Karaahmet was the recipient of the Merritt and Marjorie Cleveland Fellowship Award
  • Allison Murphy was the recipient of the J. Newell Stannard Graduate Student Scholarship Award

Katherine Andersh

Katherine Andersh

Karl Foley

Karl Foley

Berke Karaahmet

Berke Karaahmet

Allison Murphy

Allison Murphy

New Issue of Opportunities to Explore - NPAW is here!

Monday, September 18, 2017

Hot off the press, the new issue of Opportunities to Explore!

National Postdoctoral Appreciation week is here, check out all of the events inside

Latest Issue of Opportunities to Explore

New Issue of Opportunities to Explore

Monday, September 11, 2017

A new issue of opportunities to explore is now available with more events than ever before!

Celebrating a Community of Diverse Students and Trainees at URMC

Sunday, September 17 | 1:00 pm-4:00 pm | Canal side Shelter Genesee Valley Park

Sponsored by URMC: Clinical and Transitional Science Institute, Executive Committee for Diversity and Inclusion, Office for Inclusion and Cultural Development, School of Medicine and Dentistry, and School of Nursing invite you and your families to join them for food, fun, and games, to celebrate our community of diverse students and trainees at the University of Rochester Medical Center. To RSVP, please visit the link here

Read More: New Issue of Opportunities to Explore

The CARE Network

Friday, September 8, 2017

The CARE Network, a program that helps support students in distress, is now available for SMD graduate students. Students, faculty and staff are encouraged to submit a referral to the CARE Network if they believe that a student is in or headed towards distress, are aware of an act of discrimination on campus, or have a general concern for a student. The CARE Network provides recommendations to campus and community resources, outlets for safe spaces, and coaches on communication skills to work through difficult discussions and situations. You can submit a referral and/or learn more about the CARE Network at www.rochester.edu/CARE.Read More: The CARE Network

Alexandra McHale Awarded 2017 Trainee Professional Development Award

Thursday, September 7, 2017

Photo of Alexandra McHale

Join us in congratulating Ally for receiving this award from the Society for Neuroscience. The award will support travel to this year’s meeting in Washington, DC, and a special poster session for all trainees at the meeting. Ally will also benefit from admission to Professional Development Workshops, and presentation of her poster in the meeting at-large, Wednesday November 15.

Edward Ayoub Awarded Scholarship to ESH International Conference

Thursday, September 7, 2017

Edward AyoubEdward Ayoub, a 4th year student in the Cellular and Molecular Pharmacology and Physiology Program in the lab of Archibald Perkins has been awarded a scholarship to attend the ESH International Conference on AML "Molecular and Translational": Advances in Biology and Treatment.

For more information on the conference, please visit the European School of Hematology Website

Perkins / Zhang Lab

Clinical Labs Welcome First Class of Rising Med Techs

Tuesday, September 5, 2017

On Monday, Aug. 28 UR Medicine Labs and the Department of Pathology and Laboratory Medicine were pleased to welcome 12 new graduate students who are taking the first step toward a professional laboratory career.

The program is sponsored in the Department of Pathology and Laboratory Medicine. The class of 2018 is the first group to complete all of their training at the University of Rochester.

Read More: Clinical Labs Welcome First Class of Rising Med Techs

Latest Issue of Opportunities To Explore - September 4-8

Friday, September 1, 2017

The newest issue of opportunities to explore is now available, The newsletter contains information on events, resources, and more!

Highlight - Registration Closes Next Week

URBEST Retreat and Career Workshops  (Lunch Registration Deadline: Friday, September 8th)

Thursday, September 14 | 8:30 am - 4:00 pm | Class of 62 and CEL Classrooms, URMC

This year’s retreat includes guest presenter Randy Ribaudo from SciPhD joining us to present The Art of Negotiation and Networking for Success. Speakers and round-table leaders will be LeRon Nelson, Assistant Professor of Nursing; Ed Brydon, Social Media Strategist at Weill Cornell Medicine; Kirk Macolini, President & Principal Consultant at InteliSpark, LLC; Kurt Schilling, SVP Research and Technologies at The Estée Lauder Companies Inc.; and Judith Dunn, VP Global Head Clinical Development at Roche. There will be ice cream and therapy dogs at this year’s event also! Register for the event online at surveymonkey.com/r/17URBESTRetreat.

Register for URBEST Retreat and Career Workshop

Celebrating a Community of Diverse Students and Trainees at URMC (RSVP by Friday, September 8th)

Sunday, September 17 | 1:00 pm - 4:00 pm | Canal side Shelter Genesee Valley Park

Sponsored by URMC: Clinical and Transitional Science Institute, Executive Committee for Diversity and Inclusion, Office for Inclusion and Cultural Development, School of Medicine and Dentistry, and School of Nursing invite you and your families to join them for food, fun, and games, to celebrate our community of diverse students and trainees at the University of Rochester Medical Center.

RSVP for Celebrating a Community of Diverse Students and Trainees at URMC

Facebook Link to SMD GEPA Page

Read More: Latest Issue of Opportunities To Explore - September 4-8

Dumont Selected as the 2017 Recipient of the Graduate Student Society Advocacy Award

Monday, August 28, 2017

Biochemistry professor Mark Dumont, Ph.D. has been selected as the 2017 recipient of the Graduate Student Society Advocacy Award. This award, established in 1994 by the Graduate Student Society (GSS), is bestowed annually to recognize a faculty member in the School of Medicine and Dentistry who has made significant contributions in promoting excellence in graduate education through participation, facilitation, and promotion of GSS goals and events. The faculty member may be nominated by any SMD student, and is chosen by a GSS Executive Board vote.

The award will be presented at the School of Medicine and Dentistry Convocation Ceremony on Tuesday, September 12th at 4:00pm in the Class of 1962 Auditorium.

The department would like to extend congratulations to Mark on this recognition, as it is a well-deserved honor.

New Issue of Opportunities to Explore - August 28-September 1, 2017

Friday, August 25, 2017

A new issue of Opportunities to Explore is here! All the latest news and events for Graduate Students and Postdoctoral Trainees

Event Highlight

First URBEST The Grand Gesture

Friday, September 1 | 10:00 am-12:00 pm | Wegmans Hall, Georgen Institute for Data Science (Room 1201), River Campus

The first ten people that arrive at each URBEST Grand Gesture, Georgen Institute for Data Science Room 1201 (near Peet's Coffee) get a crisp $5 to buy coffee/snacks. All others are welcome to attend but must by their own snacks. What deep work you select to focus on is completely up to you. A copy of Deep Work by Cal Newport will be given to people that attend all four (Sept, Oct, Nov, Dec) sessions.  Learn more about Deep Work and The Grand Gesture online at http://calnewport.com/books/deep-work/.

Read More: New Issue of Opportunities to Explore - August 28-September 1, 2017

Biochemistry Graduate Students Sierra Fox and Chris Goodwin Explain CRISPR Gene Editing on YouTube

Wednesday, August 16, 2017

Fox, Goodwin Photo

From left: Sierra Fox and Christopher Goodwin

UR Science ROCs: What's CRISPR?

It’s no secret: URMC is home to extraordinary scientific innovations and research.

Our UR Broadening Experiences in Scientific Training (URBEST) program and our Public Relations and Communications office teamed up to offer our students and trainees the chance to highlight our research through original visuals and videos. Four videos earned prizes for their unique science storytelling and will be featured on our intranet site and the UR Medicine Facebook page throughout the month in an ongoing series called "UR Science ROCs."

What is CRISPR?

Fourth-year graduate students Chris Goodwin and Sierra Fox, and third-year graduate student Nick Nobiletti, talk about CRISPR and how it’s helping scientists edit DNA.

Goodwin is a student in the lab of Joshua Munger, Ph.D.(Department of Biochemistry and Biophysics); Fox is a student in the lab of Michael Bulger, Ph.D.(Departments of Biochemistry and Biophysics and Pediatrics); and Nobiletti is a student in the lab of Angela Glading, Ph.D. (Department of Pharmacology and Physiology).

Pharmacology Graduate Student Nick Nobiletti Explains CRISPR Gene Editing on YouTube

Wednesday, August 16, 2017

It’s no secret: URMC is home to extraordinary scientific innovations and research.

Our UR Broadening Experiences in Scientific Training (URBEST) program and our Public Relations and Communications office teamed up to offer our students and trainees the chance to highlight our research through original visuals and videos. Four videos earned prizes for their unique science storytelling and will be featured on our intranet site and the UR Medicine Facebook page throughout the month in an ongoing series called "UR Science ROCs."

What is CRISPR?

Fourth-year graduate students Chris Goodwin and Sierra Fox, and third-year graduate student Nick Nobiletti, talk about CRISPR and how it’s helping scientists edit DNA.

Goodwin is a student in the lab of Joshua Munger, Ph.D.(Department of Biochemistry and Biophysics); Fox is a student in the lab of Michael Bulger, Ph.D.(Departments of Biochemistry and Biophysics and Pediatrics); and Nobiletti is a student in the lab of Angela Glading, Ph.D. (Department of Pharmacology and Physiology).

Franchini and Meyers Win Awards

Friday, August 11, 2017

Franchini Photo

Anthony Franchini, Ph.D.

Congratulations to Anthony Franchini, Ph.D. and graduate student Jessica Meyers for both winning awards this year. Dr. Fanchini won two awards, Health and Environmental Sciences Institute (HESI) Immunotoxicology Young Investigator Travel Award and Best Presentation by a Postdoctoral Trainee Award, for his presentation, "Identification of novel gene targets of the aryl hydrocarbon receptor in dendritic cells in the context of viral infection."

Meyers Photo

Jessica Meyers

Jessica won 1st place for Best Presentation by a Student, for her presentation "Aryl hydrocarbon receptor activation during development reduces dendritic cell function later in life." Both are currently doing research in Dr. Paige Lawrence's lab. Congrats to both!

New Issue of Opportunities to Explore - August 14-18, 2017

Friday, August 11, 2017

So Much going on in this weeks issue of Opportunities to Explore, New Sections! More Seminars! More Workshops!

Center for the Integration of Research, Teaching, and Learning (CIRTL) Teaching-As-Research (TAR) Research Day

Thursday, August 17 | 9:00 a.m.-3:30 p.m. | Location TBD

CIRTL@UR would like to extend an invitation to interested students and trainees, to the University of Rochester's annual CIRTL TAR Research Day. CIRTL (the Center for the Integration of Research, Teaching and Learning) is a national consortium of 43 HEIs, whose focus is on improving the STEM learning of all students at every college and university, and thereby increasing the diversity in STEM fields and the STEM literacy of the nation. The TAR (Teaching-As-Research) program is one 'pillar' of achieving this end. Essentially, it is an opportunity for graduate students and post docs in STEM disciplines to engage in a scholarship of teaching & learning (SoTL) project, at the end of which, they present their research to the local community. More information on TAR may be found here.

On August 17, the conference will show-case the latest cohort of TAR Fellows' work, followed by a career panel, and then a workshop. Dr Sarah Rose Cavanagh, author of The Spark of Learning: Energizing the College Classroom with the Science of Emotion, will be the guest speaker; she will be facilitating a 3-hour workshop on this topic. Attendees will also receive a copy of the book for attending the research day. Registration and attendance is free. Please go here to register. For more information, please email Jennifer.Hadingham@rochester.edu .

Read More: New Issue of Opportunities to Explore - August 14-18, 2017

New Issue of Opportunities to Explore - July 31-August 4

Thursday, July 27, 2017

The latest issue of Opportunities To Explore is available now!

Coming Up This Week

Summer Scholars 2017 Poster Session

Thursday, August 3 | 9:30 am – 11:30 am | Flaum Atrium, URMC

Everyone is welcome to attend the Summer Scholars 2017 Poster Session. Refreshments will be provided. Please contact Stephanie_Corbitt@urmc.rochester.edu with any questions.

Read More: New Issue of Opportunities to Explore - July 31-August 4

Congratulations Margaret!

Wednesday, July 26, 2017

Margaret Hill

Margaret Hill

On Monday PhD candidate Margaret Hill presented her work investigating intrahepatic cholangiocarcinoma (iCCA), a form of liver cancer which morphologically resembles the biliary tract.  Margaret completed her work under guidance of Dr. Aram Hezel. Her work helps us to understand the interplay between chronic liver injury, a common risk factor for this cancer and the cell of origin as she proved that hepatocytes, as opposed to biliary cells, may serve as a cell of origin for this cancer. Further investigation into important pathways known to be activated in biliary-derived iCCA showed hepatocyte-derived iCCA similarly up-regulates the Wnt and Notch pathways and thus could be targeted for treatment.  Margaret went on to probe the importance of MCL-1, the most commonly amplified gene in iCCA, and identified a genetic subset of iCCA cancers which appear to depend on MCL-1 expression. Together, Margaret's work may have important therapeutic implications for iCCA. Well done Margaret and congratulations to Aram!

New Issue of Opportunities to Explore - July 24-28, 2017

Friday, July 21, 2017

Highlighted Events - Two social events this week

Graduate Student Society (GSS) Coffee Hour

Wednesday, July 26 | 3:00 pm – 4:00 pm | Combined Northeastern Room (1-9525 & 1-9535), URMC

Graduate Student Society (GSS)/Graduate Student Association (GSA) 2017 Wine Tour

Sunday, July 30 | 9:00 am – 4:00 pm | Seneca Lake Wineries (Belhurst, White Springs, Fox Run, Torrey Ridge)

This event is open to all graduate students and your (21 and over) guests. Tickets are $30 per person (cash only) and include transportation to and from URMC to all wineries, lunch, and tasting fees. Seats are limited so get your tickets today in the Graduate Education and Postdoctoral Affairs (GEPA) office (G-9556).

Read More: New Issue of Opportunities to Explore - July 24-28, 2017

New Issue of Opportunities to Explore - July 17-21, 2017

Friday, July 14, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

CPD Sponsored Event: Planning Your Future

Thursday, July 20 | 2:00 pm – 3:00 pm | Learning Lab 2-7520, URMC

Thinking about your future or next steps after graduation or postdoc. Not sure where to begin or feeling overwhelmed! If you said yes to one or both statements then this workshop is for you.  Planning You Future will assist you in planning your next steps in your career future. This workshop will provide information on application materials and processes for academic, industry, non-profit and government positions. Participants will also learn about all the free resources available to assist with your job search. In addition, participants will learn strategies and tips to manage job searches while completing advanced degree or postdoc opportunity. For more information about this workshop, please contact Eric Vaughn at Eric_Vaughn@urmc.rochester.edu. To register for this workshop, please visit surveymonkey.com/r/CPD-Plan .

Read More: New Issue of Opportunities to Explore - July 17-21, 2017

Payea and Mishra are Inaugural Recipients of the Sayeeda Zain Travel Award

Friday, July 14, 2017

The department of Biochemistry and Biophysics recently presented to the inaugural Sayeeda Zain Travel Award to Mathew Payea and Laxmi Narayan Mishra.

Matthew Payea is a 6th year graduate student in the Biochemistry Ph.D. program studying tRNA biology in laboratory of Eric Phizicky. Matthew received his Bachelors in Science from Eastern Illinois University, majoring in Biochemistry. Matthew used the funding provided by the Sayeeda Zain Travel Award to attend the 22nd annual meeting of the RNA Society in Prague, Czech Republic this past June. There, he gave a talk on his research defining an RNA decay pathway in yeast that destroys mutant tRNAs.

Laxmi Narayan Mishra is a postdoctoral associate working in Dr. Jeffrey J Hayes’ Lab in the Department of Biochemistry and Biophysics, University of Rochester Medical Center. He has a Masters degree from University of North Bengal, Darjeeling, India and a Ph.D. in Biochemistry from Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India. His research is focused on how epigenetic modifications alter chromosome structure to facilitate gene expression. His Dr. Mishra will use the Sayeeda Zain Travel Award to attend and present his research findings at the international EMBO conference on “The Nucleosomes: From Atoms to Genomes” at Heidelberg, Germany, in August 2017.

The Sayeeda Zain Travel Award is given semi-annually to one or more graduate students and postdoctoral fellows in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry. The award honors the life and achievements of Professor Sayeed Zain, Ph.D., a longtime faculty member in the Department of Biochemistry and Biophysics. Learn more about the award and Dr. Zain.

Matt

Matthew Payea (left) with Dr. Jeffrey Hayes

Laxmi

Laxmi Narayan Mishra (left) with Dr. Jeffrey Hayes

Budding UR Scientists and Science Communicators

Thursday, July 13, 2017

Contest Video InfographicEmily Boynton and Molly Miles from URMC’s Department of Public Relations and Communications met with a small group of URBEST trainees to discuss how the Medical Center and other academic institutions are sharing science in the social world we live in. They provided some examples of different types of visuals and videos that get great engagement on Facebook, Twitter and other social media sites. The goal?  URBEST and The Public Relations and Communications team wanted to find and offer prizes for three original visuals or videos from students and trainees that highlight UR innovation and research. Money, video packs and fame!

First prize was awarded to a team of scientists: Chris Goodwin and Sierra Fox from Biochemistry and Molecular Biology and their camera man Nicholas Nobiletti from Pharmacology and Physiology for What Is CRISPR? They split $750 of prize money.

Read More: Budding UR Scientists and Science Communicators

New Issue of Opportunities to Explore - July 10-14, 2017

Friday, July 7, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

“What We Are Really Thinking: HR Perspective to The Hiring Process”: Bio Career’s Webinar by Alicia Jones

Wednesday, July 12 | 1:00 pm – 2:00 pm | Webinar

Peek inside the mind of HR during the hiring process and learn what HR is really thinking. In this webinar, you will learn what HR is paying attention to during the different phases of recruiting and how you can improve your chances of being noticed. Each step of the recruiting process will be reviewed detailing tips and tricks you can use to prepare for your next job search. Join in and learn what HR is really thinking. For more information and to register for this webinar, please visit the registration page.

Read More: New Issue of Opportunities to Explore - July 10-14, 2017

New Issue of Opportunities to Explore

Monday, July 3, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

URBEST Career Story Q & A: Yuriy Shapovalov, PhD

Friday, July 7 | 9:00 am – 10:00 am | Anderson Room (G-5834), URMC

Dr. Shapovalov, alumnus, will highlight some of his activities as medical science liaison at Biogen, Inc.

Read More: New Issue of Opportunities to Explore

New Issue of Opportunities to Explore

Friday, June 23, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

URBEST Career Story Q & A: David McMillan, PhD

Monday, June 26 | 12:00 pm – 1:00 pm | Northeastern Conference Room (1-9525), URMC

Dr. McMillan, UR alumnus, will highlight some of his activities as a toxicologist at FDA and share personal reflections on his career trajectory: For pre-seminar reading visit our URBEST blog .

Read More: New Issue of Opportunities to Explore

Smyth wins Best Poster award

Thursday, June 22, 2017

Smyth Photo

Tim Smyth

Congratulations to second year Toxicology graduate student Tim Smyth for winning an award for his poster and presentation at the annual Toxicology Retreat. Tim’s poster was entitled “Diesel exhaust particles disrupt epithelial barrier function by altering tricellin expression”.

New Issue of Opportunities to Explore

Friday, June 16, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

Transitioning into a Non-academic Career- Hosted by American Association for the Advancement of Science (Webinar)

Tuesday, June 20 | 12:00 pm – 1:00 pm | Online Webinar

Josh Henkin, PhD, Founder, Stem Career Services, LLC, will present on the skills and best practices for transitioning from an academic environment to one of many non-academic career paths. The workshop will introduce strategies for career planning, emphasizing an ongoing process for professional development throughout your career.  For more information and to register, please click visit the presentation event site.

Read More: New Issue of Opportunities to Explore

Steve N. Georas Named to New Parkes Professorship

Tuesday, June 13, 2017

Physician-scientist Steve N. Georas, M.D., professor of Medicine, Environmental Medicine, Microbiology and Immunology, was installed as the inaugural Parkes Family Professor June 5.

Walter and the late Carmina Parkes, and their children Susan, Tom and Linda, were driven to open the first asthma center in the region. They have been a steady force in the growth of the UR Medicine’s Mary M. Parkes Center for Asthma, Allergy and Pulmonary Care, working closely with center leaders, educators and scientists. The center is located on Red Creek Drive in Henrietta and serves as the leader for the diagnosis, treatment and research of acute asthma, allergies and other pulmonary diseases.

“It was our family’s dream to honor the memory of our daughter with the center. Now, establishing a professorship allows us to make it everlasting,” said Walter Parkes, chairman of O’Connell Electric Co. The family has committed $1.5 million to the University.

Mary Parkes was diagnosed with acute asthma as a young girl and went on to study nursing. She was an intensive care unit nurse before the lung disease progressed. She was hospitalized more than 50 times in the decades before her death in 1991. The center was established in 1995.

“We are so happy to be working with UR Medicine because it is always moving forward and we are proud to be a part of that energy,” said Susan Parkes McNally, executive vice president and treasurer of O’Connell Electric and member of the University of Rochester Medical Center Board as well as its Advancement, Facilities and Quality of Care subcommittees. “We look forward to what we can continue to do and achieve in providing care for people with chronic pulmonary issues.”

McNally is a steadfast supporter and has collaborated with the Junior Builders Exchange to organize an annual golf tournament for the past 21 years to support the Parkes Center. This year’s tournament will be held Sept. 7.

“URMC’s partnership with the Parkes family is essential to the success of clinical, research and education programs designed to improve asthma care,” said Mark Taubman, M.D., CEO of URMC and UR Medicine and dean of the School of Medicine and Dentistry. “Their support will serve as a lasting tribute and will further enable the innovative work being done in pulmonary diseases.”

“The establishment of this professorship by the Parkes family will be critical to advancing the Pulmonary Division’s clinical, educational and scientific efforts,” said Paul Levy, M.D., Chairman of the Department of Medicine and the Charles Ayrault Dewey Professor of Medicine. “The mantra that long-term relationships define so many aspects of our lives could not be more true than when I think of working closely with the Parkes family for nearly three decades. The early years of planning the Parkes Center, followed by renovations and the expansion of patient services were critical to the success of the center. Now the family has ‘raised the bar’ even higher with the establishment of an endowed professorship.”

Georas is a busy clinician-scientist who balances the patient care with leadership of a National Institutes of Health-funded laboratory at URMC.

He is part of the collaborative teams caring for patients in the Medical Intensive Care Units at UR Medicine’s Strong Memorial and Highland hospitals, as well at Mary M. Parkes Center for Asthma, Allergy and Pulmonary Care.

“Steve Georas’ clinical and scientific contributions are integral to the advancement of our programs and benefit our patients on a daily basis,” said Patricia Sime, M.D., Chief of Pulmonary Diseases and Critical Care and the C. Jane Davis and C. Robert Davis Distinguished Professor in Pulmonary Medicine. “Dr. Georas is an internationally recognized physician-scientist who has focused his career on advancing our understanding of the fundamental causes of asthma and translating his research to improve the care of patients with asthma.”

Georas is studying how the lung’s immune system responds to inhaled particles, allergens and viruses, and how this process breaks down in asthma leading to potentially dangerous immune responses that can cause allergic airway inflammation and difficulty breathing. He is also working to develop techniques to identify people who are at greater risk of developing life-threatening asthma and need intensive therapies.

“The support we’ve received from the Parkes family for our asthma research is invaluable and has allowed us to make steady progress toward new pathways for asthma treatment,” Georas said. He is an internationally recognized thought leader in asthma research, and has served on advisory committees to the U.S. Food and Drug Administration, National Institutes of Health and numerous professional societies. Later this year he will chair the NIH panel review for the PrecISE Asthma Network, which will establish the next generation of asthma centers developing personalized treatments for severe asthmatics.

A graduate of Brown University and its medical school, he completed an Internal Medicine internship and residency at Duke University Medical Center. After a fellowship in Pulmonary and Critical Care Medicine at Johns Hopkins University, he joined its faculty and conducted research into asthma and allergies. In 2006, Georas joined URMC and served as chief of the Division of Pulmonary & Critical Care Medicine until 2010. Georas has been honored for his teaching and mentorship of students, post-doctoral fellows and junior faculty.

He has published more than 85 research articles and chapters on asthma immunology and the care of patients with pulmonary diseases.

Talk on Environmental Hazards at Home

Tuesday, June 13, 2017

Cait Fallone of the University’s Environmental Health Sciences Center and Jennifer Becker of the Finger Lakes Children’s Environmental Health Center will present “Could Your Home Be Making You Sick? Learn How to Stay Safe” from 12:10 to 12:50 p.m. Thursday, June 15, at the Rochester Central Library’s Bausch and Lomb Building, 115 South Ave. The lecture is part of a community health education series “Got Health?” co-sponsored by the Center for Community Health and the Central Library. Parking is available in the Court Street garage.

Grant Helps Build Understanding of Environmental Health with Hands-on Science Kits

Monday, June 12, 2017

A University of Rochester start-up company, Science Take-Out, LLC, has been awarded a nearly $1 million, two-year grant from the National Institutes of Health to further develop a line of hands-on environmental health science kits for use in community settings. The kits will help teachers and community educators increase the public’s understanding of how the environment can affect their health.

The Small Business Technology Transfer (STTR) Grant from the National Institute of Environmental Health Sciences (NIEHS) at the NIH will support modification of Science Take-Out’s current line of environmental health education kits for broader use.

Since 2008, Science Take-Out kits have provided a convenient and cost-effective way for teachers to incorporate engaging environmental health science activities into their classrooms. Now the kits, which align with national and state science education standards, will undergo a second round of extensive field testing to ensure they are relevant and accessible to diverse community audiences.

“Educating students and the general public about the link between the environment and their health allows them to make informed decisions and change their behavior to protect themselves from environmental exposures,” said Dina Markowitz, Ph.D., professor of Environmental Medicine, director of UR’s Life Sciences Learning Center.  

Markowitz and Katrina Korfmacher, Ph.D., associate professor of Environmental Medicine and director of the Community Outreach and Engagement Core (COEC) at URMC’s Environmental Health Science Center, partnered to develop and test eight current environmental health kits, which range from lessons on breast cancer to lead poisoning prevention.

With the new award Markowitz and Korfmacher will collaborate with environmental health community outreach professionals from the University of North Carolina at Chapel Hill COEC, the University of Texas Medical Branch COEC, and West Harlem Environmental Action to adapt the kits for use outside of the classroom.

Read More: Grant Helps Build Understanding of Environmental Health with Hands-on Science Kits

New Issue of Opportunities to Explore

Thursday, June 8, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

Pathology Research Day

Monday, June 12 | 8:00 am – 5:00 pm | Poster Session- Flaum Atrium & Presentations- Class if ’62 Auditorium

This year's event will take place on Monday, June 12, 2017 with a keynote speech by Perry J. Blackshear, MD, D. Phil, Deputy Chief of Signal Transduction Laboratory and Head of the Post-Transcriptional Gene Expression Group for the National Institute of Environmental Health Sciences. For a full schedule see Pathology Research Day Schedule. All presentations are free and open to the public.

Read More: New Issue of Opportunities to Explore

Si Chen, Awarded Two-year American Heart Association Predoctoral Fellowship

Thursday, June 8, 2017

Si Chen, graduate student in the laboratory of Dr. Chen Yan was awarded a two-year American Heart Association predoctoral fellowship entitled, “The Role of PDE10A in Pathological Cardiac Remodeling and Dysfunction” beginning July 1, 2017.

Project Summary

Heart failure is a leading cause of death in the United States, and is associated with significant myocardial deterioration, including hypertrophy, fibrosis and cell death, as well as contractile dysfunction and ventricular arrhythmia. There is a high demand to identify novel therapeutic targets involved in pathological cardiac remodeling and dysfunction. The objective of this project is to investigate the regulation and function of the cyclic nucleotide phosphodiesterase 10A (PDE10A) isoform in the progression of cardiac remodeling and heart failure. PDE10A primarily hydrolyzes cAMP, and under normal conditions, displays enriched expression in the striatum of the brain. Our preliminary data demonstrate that PDE10A expression is upregulated in failing mouse and human hearts. Global deficiency of PDE10A attenuates global cardiac hypertrophy and fibrosis induced by chronic Ang II infusion. In vitro studies also indicate that PDE10A inhibitor treatment reduces cardiac myocyte hypertrophy and fibroblast activation. In the brain, PDE10A primarily regulates dopamine receptor (DR)-derived cAMP. Based on these facts, we hypothesize that PDE10A plays an essential role in cardiac hypertrophy, fibrosis, and dysfunction by antagonizing cAMP/cAMP-dependent protein kinase (PKA) signaling in myocytes and cAMP/exchange factor directly activated by cAMP (Epac) signaling in fibroblasts. To test our hypothesis we propose the following two aims:

  • Aim1: Evaluate the role of PDE10A on pathological cardiac remodeling and dysfunction in vivo using genetic and pharmacological approaches.
  • Aim2: Determine the roles and underlying mechanisms of PDE10A in the regulation of cardiac myocyte and fibroblast function in vitro.

Video of 3 Minute Thesis Event

Thursday, June 8, 2017

We have the video of the full event with all presentations fully captions and with the slides running in time with the videos.

3MT Presenters, Programs & Topics

Thesis presentations in order

  • Stephanie Carpenter (Chemistry) - Solving the Mystery of Iron Chemistry
  • Sarah Catheline (Pathways of Human Disease) - Inhibiting Inflammaging to Treat Osteoarthritis(OA)
  • Scott Friedland (Genetics, Development & Stem Cells) - Pancreatic Cancer and the Tale of the Broken Librarian
  • Claire McCarthy (Toxicology) - Investigating the Toxicological Effects of Dung Biomass Smoke Exposure
  • Taylor Moon (Immunology, Microbiology and Virology) - The New Epidemic
  • Thuy-Vy Nguyen (Social-Personality Psychology) - Solitude *Winner*
  • Manisha Taya (Cellular & Molecular Pharmacology and Physiology) - Understanding Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Dependent Cancer From Bed-Side to Bench and Back Again
  • Janelle Veazey (Immunology, Microbiology and Virology) - Role of Protein Kinase D in Epithelial Cells During Respiratory Infection

Full 3MT 2017 Event Video (CC)

New Issue of Opportunities to Explore

Friday, June 2, 2017

The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars

Highlighted Event

“Ask a Scientist” table this summer at The Brighton Farmers Market. The Brighton Farmers Market has offered to provide a table during the summer market which they are calling "Ask a Scientist." The goal is to capitalize on the energy from local teach-ins and the March for Science to provide educational outreach on an ongoing basis. The market takes place on Sundays from 9am - 1pm, May 14 - November 19. The GoogleDoc includes a sign-up for two-hour time slots throughout the summer. If you are interested in participating, please sign yourself up, and pass the link on to others who may be interested. Scientists from all backgrounds and levels are welcome and encouraged to participate. More details and information on this and other events can be found in the latest issue of OTE, See below to read more.

Read More: New Issue of Opportunities to Explore

Pathology Graduate Student Wins Travel Award for Research Project

Wednesday, May 31, 2017

Second-year Pathology graduate student Madison Doolittle won second place in the School of Medicine and Dentistry’s graduate student poster competition on May 17.

Madison DoolittleSecond-year Pathology graduate student Madison Doolittle won second place in the School of Medicine and Dentistry’s graduate student poster competition on May 17.

The annual event, hosted by the Graduate Student Society, includes entries from graduate students across disciplines as an opportunity to showcase their research in their respective fields.

Madison was the lead author the abstract titled, “Investigating the Role of Zbtb40 in the Genetic Regulation of Osteoporosis” in which he and fellow researchers examined the genetic determinants of bone mineral density used to diagnose osteoporosis.

He was awarded a $300 travel scholarship.

University Research Awards span a wide range of topics

Wednesday, May 31, 2017

The awards, originally called Provost’s Multidisciplinary Awards, are funded $250,000 every year by the president and matched by the schools for a total of $500,000 annually. They are designed to help researchers advance promising lines of research so that they can obtain external funding.Read More: University Research Awards span a wide range of topics

Study: A New Way to Slow Cancer Cell Growth

Friday, May 26, 2017

cells divide

Cells grow and divide during the cell cycle

Cancer is an extremely complex disease, but its definition is quite simple: the abnormal and uncontrollable growth of cells. Researchers from the University of Rochester’s Center for RNA Biology have identified a new way to potentially slow the fast-growing cells that characterize all types of cancer. The findings, reported today in the journal Science and funded by the National Institutes of Health, were made in kidney and cervical cancer cells in the laboratory and are a long way from being applied in people. But, they could be the basis of a treatment option in the future, the authors said.

Cancer: The Cell Cycle Gone Wrong

All cells go through the “cell cycle,” a series of events that culminate in orderly cell growth and division. In cancer, the cell cycle is out of whack; cells divide without stopping and invade surrounding tissues.

Lynne Maquat

Lynne Maquat, Ph.D.

Researchers identified a protein called Tudor-SN that is important in the “preparatory” phase of the cell cycle – the period when the cell gets ready to divide. When scientists eliminated this protein from cells, using the gene editing technology CRISPR-Cas9, cells took longer to gear up for division. The loss of Tudor-SN slowed the cell cycle.

“We know that Tudor-SN is more abundant in cancer cells than healthy cells, and our study suggests that targeting this protein could inhibit fast-growing cancer cells,” said Reyad A. Elbarbary, Ph.D., lead study author and research assistant professor in the Center for RNA Biology and the department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry.

Elbarbary, who works in the laboratory of senior study author Lynne E. Maquat, Ph.D., a world-renowned expert in RNA biology, adds that there are existing compounds that block Tudor-SN that could be good candidates for a possible therapy.

Putting the Brakes on Cell Growth

Maquat’s team discovered that Tudor-SN influences the cell cycle by controlling microRNAs, molecules that fine tune the expression of thousands of human genes.

When Tudor-SN is removed from human cells, the levels of dozens of microRNAs go up. Boosting the presence of microRNAs puts the brakes on genes that encourage cell growth. With these genes in the “off” position, the cell moves more slowly from the preparatory phase to the cell division phase.

“Because cancer cells have a faulty cell cycle, pursuing factors involved in the cell cycle is a promising avenue for cancer treatment,” noted Maquat, director of the Center for RNA Biology and the J. Lowell Orbison Endowed Chair and professor of Biochemistry and Biophysics.

Maquat, who also holds an appointment in the Wilmot Cancer Institute, and Elbarbary have filed a patent application for methods targeting Tudor-SN for the treatment and prevention of cancer. Research next steps include understanding how Tudor-SN works in concert with other molecules and proteins so that scientists can identify the most appropriate drugs to target it.

Keita Miyoshi, Ph.D., staff scientist in Maquat’s lab, served as lead study author with Elbarbary. Jason R. Myers and John M. Ashton, Ph.D. from the UR Genomics Research Center played an instrumental role in the study analysis.

Read More: Study: A New Way to Slow Cancer Cell Growth

Slaughter Announces $524,000 Grant for Science Take-Out to Continue Environmental Health Education Initiative

Thursday, May 25, 2017

Congresswoman Louise Slaughter (NY-25) today announced a $524,883 federal award for Science Take-Out, a locally-based company that manufactures easy-to-use, hands-on science kits for students. This funding, administered by the Department of Human Health and Services’ (HHS) Small Business Technology Transfer (STTR) program, will expand on Science Take-Out’s successful STTR Phase I project that developed environmental health education kits for students in partnership with the University of Rochester’s Environmental Health Sciences Center.

“I’m so pleased to announce this federal funding for Science Take-Out to continue their important work educating kids and community members about science. At a time when science and fact are under siege, it is critical that organizations like this promote the building blocks of environmental education for our students. I’ve often said that Rochester is home to some of the brightest minds in the country and this is largely because of businesses like Science Take-Out, who help to inspire the next generation of researchers and environmental advocates with engaging, hands-on activities,” said Rep. Slaughter.

Currently, environmental health is typically covered minimally, if at all, in secondary school classrooms and there are also very few available hands-on activities that engage the general public in learning about concepts related to environmental health. Science Take-Out develops and manufactures innovative and easy-to-use hands-on science activity kits that are used in schools throughout the country. This new award will support Science Take-Out’s efforts to gather evidence on the impact of environmental health science kits on students’ learning and to modify the kits for use in diverse, community-based settings.

“Science Take-Out believes in the power of hands-on, experiential learning. That’s what our science kits do: provide students with the fun, easy-to-use tools they need to broaden their knowledge about science and health. We are a team of experienced science educators always looking for more ways to engage young students and this grant will go a long way in supporting that mission. Thank you, Congresswoman Slaughter, for your support of federal investments in research and science education,” said Dina Markowitz, president of Science Take-Out and professor of Environmental Medicine at the University of Rochester.

This funding expands Science Take-Out’s successful STTR Phase I project that developed and pilot-tested eight hands-on Science Take-Out kits on topics in environmental health science in partnership with the University of Rochester’s Environmental Health Sciences Center. These kits aid students in learning important health concepts such as: the biological effects of lead, sun and pesticide poisoning and health issues associated with antimicrobial agents found in consumer products.

Lowery Receives Vincent du Vigneaud Award at Commencement 2017

Wednesday, May 24, 2017

ania-Majewska Speaking About Rebecca Lowery

Rebecca Lowery and Edith Lord

ania-Majewska Speaking About Rebecca Lowery

Ania Majewska Speaking about Rebecca Lowery

Rebecca Lowery, Ph.D., a graduate of the laboratory of Dr. Ania Majewska, received the Vincent du Vigneaud Award at Commencement 2017 for her thesis titled “The Role of Microglia and Fractalkine Signaling in Experience-dependent Synaptic Plasticity”.

This award is conferred by the Office of Graduate Education at the School of Medicine and Dentistry to a graduating student from any program whose thesis is judged superior and unique in potential for stimulating and extending research in the field. The award is given in honor of Vincent du Vigneaud, (1901-1978) who received his Ph.D. in Biochemistry (formerly known as Vital Economics) in 1927 at the University of Rochester School of Medicine and Dentistry, studying on the sulfur component of insulin.

Papasergi-Scott, Taya, and Wang Win Awards at the GSS Annual Poster Session Competition

Tuesday, May 23, 2017

Congratulations to the following students who won awards at the Graduate Student Society Annual Poster Session Competition held on May 6, 2016.

Makaía M. Papasergi-Scott, working in the laboratories of Dr. Gregory G. Tall and Dr. Robert Freeman, was awarded 1st Place and received a $500 travel reward for her poster titled “Phosphorylation of Ga Chaperone Ric-8A Regulates its Function”.

Manisha Taya working in the laboratory of Dr. Stephen R. Hammes, and Xiaowen Wang working in the laboratory of Dr. Mark D. Noble, tied for 3rd place and received $100 travel grants for their posters titled “The Role of Estrogen and Glycoprotein-NMB in Lymphangioleiomyomatosis (LAM) Progression” and “Identifying c-Cbl as a Critical Point of Intervention in Acquired Tamoxifen Resistant Breast Cancer”, respectively. 

Stoveken Receives Wallace O. Fenn Award at Commencement 2017

Tuesday, May 23, 2017

Hannah Stoveken With Gregory TallHannah Stoveken, a graduate from the Laboratory of Dr. Gregory G. Tall, received the Wallace O. Fenn Award at Commencement 2017 for her thesis titled “Activation of Adhesion G Protein-coupled Receptors by a Tethered Agonist: Mechanism of Action and Pharmacological Modulation”.

The Wallace O. Fenn Award is given annually to a graduating student judged to have performed especially meritorious research and who presented a Ph.D. thesis suitable to honor the name of Dr. Fenn, a Professor of Physiology at the University of Rochester School of Medicine and Dentistry from 1924 to 1961.

Taya wins Knockout Rounds at ENDO 2017 and Finalist in UofR Three Minute Thesis (3MT®) Competition

Tuesday, May 23, 2017

Manisha Taya, graduate student in the Hammes Lab, won the People's Choice First Place Award in the Knockout Rounds competition at the annual ENDO 2017 conference, held April 1-4, for her presentation of her research on lymphangioleiomyomatosis. View a video featuring interviews with the winners.

Taya was also a finalist in The University of Rochester Three Minute Thesis (3MT®) Competition held on Thursday May 11, 2017. 3MT is an academic competition that challenges PhD students and postdoctoral appointees to describe their research within three minutes to a general audience.

Catheline Awarded in Three-Minute Thesis Competition

Monday, May 15, 2017

Sarah CathelineCongratulations to Sarah Catheline for winning the People’s Choice Award at the University of Rochester’s Three Minute Thesis public competition held on May 11 at URMC.

Sarah is a fourth-year graduate student in the Pathways of Human Disease Ph.D. program and works in the lab of Dr. Jennifer Jonason. Her presentation, “Inhibiting Inflammaging to Treat Osteoarthritis (OA),” was one of eight to be accepted into the final round.

This year marks the second annual Three Minute Thesis public competition at the University of Rochester, which encourages participants to share their research in simple language that's both persuasive and easy for the average person to understand. 

The event is open to current Ph.D. and professional doctorate (research) candidates in or beyond their third year of study. It’s also open to postdoctoral researchers. Winners receive travel awards ranging from $250-750.

The event is sponsored by the School of Medicine and Dentistry Center for Professional Development, the School of Arts, Science and Engineering Graduate Studies Office, the Graduate Student Society, and Graduate Student Association.

Three Minute Thesis Awards: 

  • Judge’s Winner: Thuy-vy Nguyen (Runner Up: Scott Friedland)
  • People's Choice Award: Sarah Catheline 

Presentations: 

  • Stephanie Carpenter: Solving the Mystery of Iron Chemistry
  • Scott Friedland: Pancreatic Cancer and the Tale of the Broken Librarian
  • Sarah Catheline: Inhibiting Inflammaging to Treat Osteoarthritis (OA)?
  • Claire McCarthy: Investigating the Toxicological Effects of Dung Biomass Smoke Exposure
  • Taylor Moon: The New Epidemic
  • Thuy-vy Nguyen: Solitude
  • Manisha Taya: Understanding Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Dependent Cancer From Bed-Side to Bench and Back Again
  • Janelle Veazey: Role of Protein Kinase D in Epithelial Cells During Respiratory Infection
     

Scott Friedland takes 2nd place in the Three Minute Thesis (3MT) competition

Monday, May 15, 2017

Scott Friedland with Award

On May 11th, 2017, Scott Friedland took 2nd place in the Three Minute Thesis (3MT) competition with his talk entitled, “Pancreatic Cancer and the Tale of the Broken Librarian. 3MT, created at The University of Queensland in Australia, is an effort to bring awareness to research and scientific communication, in which competitors have 3 minutes to get across the thrust of their thesis to a general audience. Scott is an MD/PhD student currently working in the lab of Dr. Aram Hezel in the Genetics, Development, and Stem Cells program. His research focuses on defining the role of ARID1A and the SWI/SNF complex in pancreatic cancer and development.

Read More: Scott Friedland takes 2nd place in the Three Minute Thesis (3MT) competition

New Opportunities to Explore Newsletter Issue - May 15-19, 2017

Friday, May 12, 2017

The latest issue of OTE is available, with all the latest events coming your way as well as the first in a series of introductions to the GEPA Staff

Read More: New Opportunities to Explore Newsletter Issue - May 15-19, 2017

Interviewing Workshop a Success

Wednesday, May 10, 2017

The Interviewing Workshop: “Preparing for the Job Interview”, was another successful workshop. We had 11 participants from various programs throughout the School of Medicine and Dentistry participate in the interactive workshop. The workshop provided students and trainees information on how to prepare for various types of interview styles including phone, Skype, in-person and group. Participants gained knowledge on general, behavioral, and situational interview questions and then put what they learned into practice by answering various interview questions with a partner and among the larger group. In addition, we discussed how to prepare for a presentation that you may be asked to deliver during the interview and what things to do post interview to help show an employer your continued interest in the position.

Objectives Covered

  • Understand how to prepare for a job interview
  • Learn about the different types of interviews
  • Gain an understanding of the various types of interview questions (general interview questions, behavioral, and situational)
  • Practice how to successfully answer various types of questions in an interview situation
  • For upcoming event information, please visit the CPD websiteRead More: Interviewing Workshop a Success

New Opportunities to Explore Edition - May 8-12, 2017

Friday, May 5, 2017

A new issue of Opportunities to Explore

This issue of OTE contains this weeks news on scholarships, a job interview workshop and the final of the 3 minute thesis competition

This issue also contains upcoming event information:

  • Commencement
  • Graduate women in science seminar featuring guest speaker Dr. Jane Skok, speaking on career re-entry
  • The 4th annual alumni event
  • Graduate Student Society (GSS) Poster Session
  • URBEST Career Story Q & A: Elizabeth Schiavoni, MS
  • University of Rochester Toastmasters Club guest day event
  • CPD Sponsored Event: Qualifying Exam Preparation and Writing Workshop
  • CPD and URBEST Sponsored Event: Lead with Your Top 5: A StengthsQuest Event

Plus...

Volunteer Opportunities in Science

Relevant Reads

Read More: New Opportunities to Explore Edition - May 8-12, 2017

Congrats to Gianluca Di Maria on the Winning an Award at the 2017 Neuro Film Festival

Wednesday, April 26, 2017

Congrats to Halterman Lab Medical Student Intern, Giancarlo DiMaria for his Neuroscience Is…™ Rewarding winning video, “The Brain Scientist: Neuroscience is Rewarding.” Following a neurologist in the clinic and a neuroscientist in the lab, this video highlights the challenging but rewarding nature of a career in neuroscience.

GDSC Students attend the March for Science

Tuesday, April 25, 2017

Students from the Genetics Program attended The Rochester March for Science on Saturday April 22

Schematic overview of proposed work
Fanju Meng (Biteau Lab), Sreejith (Biteau Lab), Emily Wexler (Portman Lab),
Sebastian Rojas Villa (Biteau Lab), Robert Hoff (Bohmann Lab), Andrew Allbee (Biteau Lab)

2017 Curtis Award

Monday, April 24, 2017

photo of Jessica Hogestyn

Neuroscience Graduate Program student Jessica Hogestyn, a student in the Mayer-Pröschel Lab, has been selected as one of the winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. Her nomination material exemplified her ability as an outstanding educator with bright future.

Congratulations Jessica!!

New Opportunities to Explore Newsletter Issue - April 24-28, 2017

Friday, April 21, 2017

The latest edition contains information regarding awards, career development events, Q&A sessions with scientists and much moreRead More: New Opportunities to Explore Newsletter Issue - April 24-28, 2017

Fishing for Answers: Does an Omega-3 Fatty Acid Improve Heart Health?

Friday, April 7, 2017

Study results are mixed on whether omega-3 fatty acids, nutrients found most readily in fish like salmon and tuna, are beneficial when it comes to preventing heart disease.

Read More: Fishing for Answers: Does an Omega-3 Fatty Acid Improve Heart Health?

BMB, BSCB Students Win 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student

Saturday, April 1, 2017

BMB and BSCB graduate students, Lauren Benoodt, Tyler Couch, and Lisa Houston have been selected as joint winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. The students will be presented with a certificate, as well as checks of $700 for each. The three of them were TA’s for IND 408 (Advanced Biochemistry) in the Fall of 2016.

The Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student was established to recognize graduate students who advance the teaching mission of the University by providing highly skilled and innovative undergraduate instruction. The strongest nominations show innovation in teaching and a positive impact on the learning of undergraduates.

Congratulations Lauren, Tyler, and Lisa!

Paula Alio Awarded J. William Fulbright Scholarship

Monday, March 27, 2017

Paula Alio, PhD, Assistant Professor of Public Health Sciences, has been awarded the J. William Fulbright Scholarship grant to study HIV among women (sex workers) in Niger.

Pathology Grad Students Present Results of CTSI Incubator

Wednesday, March 22, 2017

Christopher Farnsworth,  Ashlee MacDonald, and Eric Schott pose in  front of the podium at the Orthopaedic Research Society Meeting.Results from the 2015 CTSI Incubator project suggest there is a connection between gut microbes in obesity and impaired musculoskeletal health. Members of the Incubator project team presented results at the Orthopaedic Research Society (ORS) Annual Meeting this week that suggest manipulating the gut microbiome in obese animals can slow osteoarthritis and speed healing after fracture.

Read More: Pathology Grad Students Present Results of CTSI Incubator

Dr. Ossip Appointed to FDA Tobacco Products Scientific Advisory Committee

Tuesday, March 21, 2017

Deborah J. Ossip, PhD, Professor, Director Smoking Research Program, has been appointed to the FDA Tobacco Products Scientific Advisory Committee (TPSAC)

Read More: Dr. Ossip Appointed to FDA Tobacco Products Scientific Advisory Committee

Monique Mendes Serves as Judge at STEP UP to Medicine Poster Session

Friday, March 17, 2017

The Regional Science and Technology Entry Program (STEP UP) to Medicine conference was hosted by the University of Rochester on March 4th, 2017. NGP student, Monique Mendes was invited to serve as a judge at the poster session during the event based on her earlier involvement with that Program. Back in fall 2016, Monique and the Pre-doctoral Organization for Neurosciences (PONs), was invited to meet with the STEP UP to MEDICINE participants to discuss the brain and to share their neuroscientific research experiences. STEP UP to MEDICINE is a state funded program intended to help gifted and motivated high school students from economically disadvantaged backgrounds into undergraduate and graduate Science and Technology programs across the state of New York. On March 4th, the University of Rochester hosted STEP UP to Medicine conference attended by 15 statewide STEP programs representing 10 students each. The high school students had a chance to meet with their peers from other institutions, the UR physicians, technical staff, medical, and graduate students.

Read More: Monique Mendes Serves as Judge at STEP UP to Medicine Poster Session

Rahman Receives Senior Toxicologist Award From The Society of Toxicology

Tuesday, March 14, 2017

Rahman plaque

Irfan Rahman, Ph.D., Professor of Environmental Medicine, has been awarded a Senior Toxicologist Award by the Society of Toxicology - Associations of Scientists of Indian Origin. The award was presented to Dr. Rahman in the presence of many Society of Toxicology (SOT) meeting attendees as well as several NIEHS officials.

He received the award at the SOT 56th Annual Meeting and ToxExpo in Baltimore, MD on March 13th. This year’s meeting, like its predecessors, was designed to provide members with access to cutting-edge science, networking opportunities, and career development resources through its various events and activities:

  • 160+ Scientific Sessions, covering diverse topics such as age- dependent neuroimmunotoxicological effects, cardiopulmonary consequences of gestational toxicant exposure, and novel in vitro and in silico platforms, among dozens of others
  • 50+ receptions and social events hosted by SOT Regional Chapters, Special Interest Groups, Specialty Sections, Committees, and other toxicology-related organizations
  • 13 Continuing Education courses and other education opportunities
  • ToxExpo, featuring more than 330 exhibitors providing products, services, and technology created to benefit the toxicology community

Congratulations Dr. Rahman!

Rahman award

Rahman

Hocking and Roy Receive Patent

Wednesday, February 22, 2017

The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (U.S. Patent No. 9,572,869; awarded February 21, 2017) has recently been assigned to the UR with inventors Denise Hocking, Ph.D. and Daniel Roy, Ph.D. (BME B.S.‘06, Ph.D.‘12). The patent relates to the use of recombinant fibronectin-based peptides for wound healing and tissue regeneration applications. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Topical application of fibronectin matrix mimetic peptides to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization.

Denise Hocking, PhD is a Professor of Pharmacology and Physiology and of Biomedical Engineering. Daniel Roy is a Scientist at KeraNetics, LLC, a biotechnology company located in Winston-Salem, North Carolina that develops keratin-based biomaterials for wound healing applications.

Scott Steele selected to serve on the Food and Drug Administration's (FDA) Science Board

Monday, February 13, 2017

Scott Steele, PhD, Director of the CTSI Regulatory Science Core has been selected to serve on the Food and Drug Administration's (FDA) Science Board. The Board provides advice to the Commissioner and other FDA offcials, exploring issues from gene editing or regulation of opioids to food safety, and aims to help the FDA keep pace with technical and scientific developments.

Read More: Scott Steele selected to serve on the Food and Drug Administration's (FDA) Science Board

Maquat Receives Lifetime Achievement Award in Science from International RNA Society

Tuesday, February 7, 2017

Photo of Lynne Maquat

Lynne E. Maquat, Ph.D. has spent her career unraveling what happens in our cells during disease, making seminal contributions to our understanding of RNA’s role in sickness and in health. She’s also committed countless hours to mentoring the next generation of researchers and advocating for young women in the sciences. For these exceptional efforts, she’s receiving the 2017 Lifetime Achievement Award in Science from the international RNA Society.

The J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry, Maquat began her professional career studying inherited anemias. She discovered a quality control process that blocks the creation of toxic proteins that cause disease. Known as nonsense-mediated mRNA decay or NMD, this process plays a part in one third of all inherited diseases, such as cystic fibrosis and muscular dystrophy, and one third of all acquired diseases, including a number of cancers.

“This award recognizes Lynne’s pioneering contributions to understanding the mechanisms of RNA, as well as her outstanding leadership, support and commitment to our field, including her role as a model for new generations of scientists,” said Juan Valcarcel Juarez, current president of the RNA Society, who works at the Centre for Genomic Regulation in Barcelona, Spain.

James McSwiggen, CEO of the RNA Society, added, “I can’t imagine a more appropriate choice of awardee.”

Read More: Maquat Receives Lifetime Achievement Award in Science from International RNA Society

Scientists develop new flu vaccines for dogs

Monday, January 30, 2017

Scientists at the University of Rochester School of Medicine and Dentistry have developed, for the first time, two new vaccines for canine influenza. This research is not only important for improving the health of our furry friends, but for keeping us safe, too. Dogs that have been infected with multiple influenza viruses have the potential to act as "mixing vessels" and generate new flu strains that could infect people. This hasn't happened yet, but experts say it's possible.

Today, veterinarians use vaccines that include inactivated or killed flu virus, but experts say they provide short-term, limited protection. Scientists led by Luis Martinez-Sobrido, Ph.D., associate professor in the department of Microbiology and Immunology created two "live-attenuated" vaccines against H3N8 canine influenza virus, which is currently circulating in dogs in the U.S. Past research shows that live-attenuated vaccines, made from live flu virus that is dampened down so that it doesn't cause the flu, provide better immune responses and longer periods of protection.

Read More: Scientists develop new flu vaccines for dogs

URMC Drug Extends Effectiveness of HIV Therapy

Monday, January 30, 2017

Major Step toward Longer-Lasting HIV Treatment

Image of hand stating Stop HIV

A drug developed at the University of Rochester Medical Center extends the effectiveness of multiple HIV therapies by unleashing a cell’s own protective machinery on the virus. The finding, published today in the Journal of Clinical Investigation, is an important step toward the creation of long-acting HIV drugs that could be administered once or twice per year, in contrast to current HIV treatments that must be taken daily.

The drug, called URMC-099, was developed in the laboratory of UR scientist Harris A. (“Handy”) Gelbard, M.D., Ph.D. When combined with “nanoformulated” versions of two commonly used anti-HIV drugs (also called antiretroviral drugs), URMC-099 lifts the brakes on a process called autophagy.

Normally, autophagy allows cells to get rid of intracellular “trash,” including invading viruses. In HIV infection, the virus prevents cells from turning on autophagy; one of the many tricks it uses to survive. When the brake on autophagy is lifted, cells are able to digest any virus that remains after treatment with antiretroviral therapy, leaving cells free of virus for extended periods of time.

Photo of Dr. Gelbard

Harris A. (“Handy”) Gelbard, M.D., Ph.D.

“This study shows that URMC-099 has the potential to reduce the frequency of HIV therapy, which would eliminate the burden of daily treatment, greatly increase compliance and help people better manage the disease,” said Gelbard, professor and director of UR’s Center for Neural Development and Disease, who has studied HIV/AIDS for the past 25 years. The finding builds on previous research that Gelbard conducted with Howard E. Gendelman, M.D., professor and chair of the Department of Pharmacology/Experimental Neuroscience at the University of Nebraska Medical Center.

Read More: URMC Drug Extends Effectiveness of HIV Therapy

AAMC Taps URMC for National Community Health and Equity Initiative

Thursday, January 12, 2017

The University of Rochester Medical Center is one of only eight institutions chosen by the Association of American Medical Colleges (AAMC) to join an effort to improve health equity and the health of communities nationwide.Read More: AAMC Taps URMC for National Community Health and Equity Initiative

Deborah Ossip, PhD, Elected President of the Society for Research on Nicotine and Tobacco.

Thursday, January 12, 2017

Deborah J. Ossip, Ph.D., professor of Public Health Sciences and Oncology, has been elected 2016 president of the Society for Research on Nicotine and Tobacco (SRNT). The international society coordinates and advances research related to nicotine and tobacco from molecular to societal levels, and it publishes the journal Nicotine & Tobacco Research.

Read More: Deborah Ossip, PhD, Elected President of the Society for Research on Nicotine and Tobacco.

Todd Jusko, PhD awarded a one year research contract from the Centers for Disease Control and Prevention

Sunday, January 1, 2017

Todd Jusko, PhD, Assistant Professor of Epidemiology, was awarded a one year research contract from the Centers for Disease Control and Prevention. The overall objective of the project is to examine the relationship between in utero and postnatal blood lead concentrations and children's immune system function.

Rahman Article Chosen as One of URMC's Top 10 News Stories of 2016

Saturday, December 31, 2016

Irfan Rahman's study, published in Oncotarget in November, has been chosen by the URMC as one of the top news stories of 2016.

The study is the first-ever showing that E-cigarettes cause damage to gum tissue. Rahman's research suggests that electronic cigarettes are as equally damaging to gums and teeth as conventional cigarettes.

Read More: Rahman Article Chosen as One of URMC's Top 10 News Stories of 2016

GDSC Student to join the Steven’s Laboratory at Harvard Medical

Tuesday, December 27, 2016

Nicole Scott-Hewett

Nicole Scott-Hewett

Nicole Scott-Hewett, a recent graduate of the GDSC program will be joining Beth Steven’s laboratory at the Boston Children's Hospital F.M. Kirby Neurobiology Center. There Nicole will be involved in projects related to understanding mechanisms of complement and microglia-mediated pruning in development and in disease models. With her paper in this month’s issue of PLoS Biology on lysosomal dysfunction, Nicole leaves us with a fanfare. We wish her all the best for her new beginnings in Boston!

Repurposed drugs may offer improved treatments for fatal genetic disorders

Wednesday, December 21, 2016

Department of Biomedical Genetics researchers believe they have identified a new means of treating some of the most severe genetic diseases of childhood, according to a new study in PLOS Biology. The diseases, called lysosomal storage disorders (LSDs), are caused by disruptions in the functioning of the stomach of the cell, known as the lysosome. LSDs include Krabbe disease, Gaucher disease , metachromatic leukodystrophy and about 40 related conditions. In their most aggressive forms, they cause death of affected children within a few years after birth.

Nicole Scott-Hewett

Nicole Scott-Hewett

Christopher Folts

Christopher Folts

The research was spear-headed by Nicole Scott-Hewett and Chris Folts, two recent graduates of the program in Genetics, Development and Stem Cells. Led by the article's corresponding author Mark Noble, Ph.D., the team discovered for the first time how specific toxic waste products that accumulate in LSDs cause multiple dysfunctions in affected cells. They also found that several drugs already approved for other uses have the unexpected ability of overcoming the cellular toxic build-up, providing new opportunities for treatment. Key to this discovery was the finding that these drugs can help restore normal acidification of the lysosome.

In a mouse model of Krabbe disease (one of the most severe LSDs), Drs. Folts and Scott-Hewett found that their lead study drug, colforsin, increased survival as effectively as in studies where disease-causing mutations were corrected by gene therapy. Colforsin is approved in Japan to treat cardiac disease, which provides information to investigators about its use in humans.

Increased survival in mice occurred even though treatment was started later than is necessary for gene therapy. The research treatment also decreased damage to the brain and improved the quality of life in the diseased mice. All of these outcomes are critical goals in the treatment of children with Krabbe disease or related illnesses, said Noble, who is the Martha M. Freeman, M.D., Professor in Biomedical Genetics at URMC.

"One of the great challenges in these diseases is that they are both rare and come in many different varieties, and advances have tended to focus on single diseases," Noble said. "In contrast, our findings suggest our treatments will be relevant to multiple disorders. Also, we saw benefits of our treatment even without needing to correct the underlying genetic defects. That gives us great hope that we could combine our treatments with other candidate approaches to gain additional benefits."

If the results can be translated into humans, Noble said, the repurposed drugs might improve the quality of life for afflicted children while more difficult experimental genetic treatments are pursued. The complete study can be found at: PLoS Biology

Read More: Repurposed drugs may offer improved treatments for fatal genetic disorders

Meng Wang, a former graduate student in the laboratory of Dr. Bohmann, has been named a Howard Hughes Medical Institute (HHMI) Faculty Scholar

Tuesday, December 20, 2016

Meng Weng

Meng Weng, PhD

Dr. Meng Wang a former graduate student in the laboratory of Dr. Bohmann, has been named a Howard Hughes Medical Institute (HHMI) Faculty Scholar, a grant awarded to outstanding young scientists and researchers who have made impressive accomplishments and have a bright future in making groundbreaking contributions.

Dr. Wang is currently an associate professor at Baylor College of Medicine, where she studies the influence of endocrine and metabolic functions on aging, using C. elegans as a model system.

Research Led by Hucky Land Points to Prostate Cancer Tool

Tuesday, December 20, 2016

Researchers from Wilmot Cancer Institute and Roswell Park Cancer Institute in Buffalo reported in the journal Oncotarget that they have discovered a possible new tool for predicting whether prostate cancer will reoccur following surgery based on the expression patterns of four genes.

The Wilmot/Roswell Park tool was able to predict recurrence, based on human tissue samples and known patient outcomes, with 83 percent accuracy. Currently the only other way to estimate tumor aggressiveness is with a Gleason score, a grading system for prostate tumors that has limited power in most cases, researchers said.

Some prostate cancers grow very slowly, and when the disease is detected early, the five-year survival rates are nearly 100 percent. However, some men are diagnosed with more aggressive localized disease and, even after having a radical prostatectomy, cancer will return in one-third of patients.

“Our study sought to improve upon the prediction tools used in these types of cases so that oncologists would know with more certainty when to recommend additional treatment, such as radiotherapy, immediately after surgery,” said Hucky Land, Ph.D., director of research at Wilmot and the Robert and Dorothy Markin Chair of the Department of Biomedical Genetics, who led the research. (Most patients receive no further treatment after surgery.)

Earlier, Land’s lab discovered a large group of non-mutated genes that are actively involved in cancer development. After analyzing expression of this gene set in frozen prostate cancer tissue samples, researchers discovered the four-gene signature, which was expressed differently in prostate cancer that later returned. Justin Komisarof, an M.D./Ph.D. student in the Land lab, developed the various algorithms and methods to evaluate the gene signature. The research team concluded that their tool outperformed other scientific methods, and they have applied for a U.S. patent.

The National Institutes of Health and Wilmot Cancer Institute/Roswell Park Cancer Institute Collaboration Pilot Funds supported the research. Chief collaborators from Roswell Park include Carl Morrison, M.D., executive director of the Center for Personalized Medicine, and James Mohler, M.D., associate director and senior vice president for translational research at Roswell.

Read More: Research Led by Hucky Land Points to Prostate Cancer Tool

Jimmy Zhang, Awarded Two-year American Heart Association Predoctoral Fellowship

Friday, December 16, 2016

Jimmy Zhang, graduate student in the laboratory of Dr. Paul Brookes was awarded a two-year American Heart Association predoctoral fellowship entitled, “The Development of Novel Acute Myocardial Infarction Therapeutics Using Metabolomics and High-Throughput Screening” beginning January 1, 2017.

Project Summary:
Paradoxically, current AMI therapies have the common goal of promoting reperfusion and, in doing so, trigger events that lead to cell death. As a result, there is a need for new therapeutics that limit reperfusion-induced injury. Many of the pathologic cellular events of reperfusion-induced injury can be attributed to maladaptive metabolic remodeling. One particular metabolite of interest is succinate, which accumulates during ischemia. Upon reperfusion, succinate is consumed in the electron transport chain by Complex II, generating reactive oxygen species at Complex I. This reverse electron transport (RET) appears to be a major contributor to IR injury. Yet, despite the relevance of RET to IR injury, the pathway of succinate accumulation has yet to be elucidated. Additionally, succinate accumulation during ischemia might contribute to the generation of the mitochondrial membrane potential by permitting Complex I activity. This membrane potential can then be used for functions such as membrane transport and maintenance of redox status. In our preliminary data, nornicotine was identified as a potentially cardioprotective candidate, and was shown to inhibit Complex I activity. Inhibition of RET could be the mechanism of protection by nornicotine. Using high-throughput screening and metabolomic approaches, this project will determine whether inhibition of RET is a rapid metabolic adaptation that is conserved across cardioprotective strategies (nornicotine treatment, ischemic preconditioning, and ischemic postconditioning). Finally, the pathway and function of succinate accumulation will be investigated by measuring membrane potential and redox status in isolated mitochondria. Overall, this project aims to investigate RET in IR injury with the goal of developing novel therapeutics for AMI.

Dr. Robert Block awarded a 2-year research grant from the international Atherosclerosis Society and Pfizer Pharmaceutical Corporation

Thursday, December 15, 2016

Robert Block, MD, MPH, was awarded a 2-year research grant from the international Atherosclerosis Society and Pfizer Pharmaceutical Corporation. The overall goal is to partner with patients with familial hypercholesterolemia (a genetic disease that causes very premature heart attacks and strokes) and physicians in order to build and test educational/motivational information about this disease within the University of Rochester's electronic health record.

Researchers Identify Brain Region as Possible Target for Dementia Prevention

Tuesday, December 13, 2016

A University of Rochester study has found that older adults with excellent memories have more efficient connections between specific areas of the brain — findings that could hold promise for the prevention of dementia and cognitive decline.

Although researchers have historically viewed memory deterioration as an inevitable part of the aging process, a small group of older adults — called “supernormals” — are able to maintain their memory capacities much better than their peers. Feng (Vankee) Lin, PhD, an assistant professor in the University of Rochester School of Nursing, is spearheading a new approach to the study of Alzheimer’s disease by exploring what can be learned from these individuals.

In a study on the topic published in Cortex, an international journal devoted to the study of cognition and the relationship between the nervous system and mental processes, Lin and her team explored differences in brain function among three groups of older adults: supernormals, who were defined as having higher than average memory scores for their age, older adults diagnosed with amnestic mild cognitive impairment who are at high risk for developing Alzheimer’s disease, and a healthy control group. The study is the first to compare the brain function of supernormals to those who are at risk for developing Alzheimer’s.

Read More: Researchers Identify Brain Region as Possible Target for Dementia Prevention

Mitchell O'Connell Lab To Open

Monday, December 12, 2016

Current Postdoctoral Berkeley Fellow, Mitchell O'Connell, Ph.D. is set to open his new lab in April 2017, in the department of Biochemistry & Biophysics, at URMC. Currently Mitch is working in Jennifer Doudna's lab and his research aims to understand the mechanisms of RNA-mediated gene regulation through the development of new RNA-targeting tools based on CRISPR/Cas technology.

Welcome Mitch!

University Research Award helps team explore regeneration in a critical layer of the cornea

Friday, December 9, 2016

Illustration of structure of cornea

The structure of the cornea.
(Keratomania.com eye diagram by
Chabacano,via Wikimedia Commons.)

On the backside of the cornea is a single layer of cells that plays an all-important role, maintaining just the right fluid balance to keep the cornea transparent so that light can enter the eye. Until recently, it was believed this layer, called the corneal endothelium, is incapable of replacing its damaged cells. As more cells become damaged, the cornea becomes opaque, leading to loss of vision and, ultimately, to as many as 30,000 endothelium transplants a year in the United States alone.

A team of University researchers is exploring the possibility that stem cells on the outer edges of the cornea, given the right stimulation, can migrate into the endothelium to replace damaged cells. (Undifferentiated stem cells develop into specialized cells.) The work raises the possibility of restoring vision without the need for transplants.

The team is led by Amy Kiernan, associate professor of ophthalmology, and includes Jannick Rolland, the Brian J. Thompson Professor of Optical Engineering; Patrice Tankam, a senior scientist in the Center for Visual Science; Changsik Yoon, a graduate student in Rolland’s lab; Rebecca Rausch, a graduate student in Kiernan’s lab; and Holly Hindman, former associate professor of ophthalmology, now in private practice but still consulting on the project. They are supported with a $75,000 University Research Award. The URA program is designed to help researchers develop preliminary data or proof of concept needed to leverage larger federal or foundation awards to carry a promising project to completion.

There have been tantalizing clinical hints that the corneal endothelium may have regenerative capabilities, Kiernan says. For example, there have been cases in which endothelial transplants failed to engraft, but the cornea cleared up anyway, with regeneration of the endothelium occurring on its own. “So it seems that if something is done that stimulates a progenitor or stem cell population, most likely those in the periphery of the cornea, there is some regenerative capacity in the endothelium – just based on clinical studies,” Kiernan says.

Her team will attempt to identify the potential stem cells that might be stimulated to migrate to the endothelium to repair damage. They will use mouse models from Kiernan’s lab in which adult stem cells can be permanently tagged with fluorescent biomarkers and tracked even after they differentiate into other cells. The identification and tracking of those cells will be done by refining a novel imaging approach developed in Rolland’s lab. Called Gabor domain optical coherence microscopy, the technology allows rapid, noninvasive imaging of cellular structures beneath the surface of the skin or within the human eye – in greater detail than traditional imaging with optical coherence tomography.

“Think of it as a high-definition, volumetric imaging,” Rolland says. “But we also want to know what kind of cells we are looking at, so we are integrating fluorescence imaging with the high-definition volumetric microscopy so we can do both.” The team represents a combination of pertinent expertise: cell development and regeneration (Kiernan and Rausch), imaging (Rolland, Tankam, and Yoon), and the biological basis for corneal and ocular surface diseases in humans (Hindman). The University Research Award funding is helping support graduate students and technicians working on the project, and the cost of mice and supplies. “Pilot funding like this is so important, especially with NIH grants shrinking,” Kiernan says.

“It’s really helpful to be able to bridge this kind of interdisciplinary effort,” says Rolland. “You need to work together a little bit to understand the challenges involved and what you need to do to secure preliminary data, to show we have a pathway. “It takes time to get data, so even a small grant that provides a bridge for a year or two can make a huge difference.”

Nina Schor to Step Down as Children's Hospital Pediatrician-in-Chief

Wednesday, December 7, 2016

Nina Schor, M.D., Ph.D., William H. Eilinger Chair of Pediatrics at the University of Rochester Medical Center (URMC), will step down as chair in June 2017. Schor served 11 years as pediatrician-in-chief at UR Medicine’s Golisano Children’s Hospital, and under her leadership, the Department of Pediatrics fulfilled a decades-long dream of building a standalone children’s hospital in Rochester; the new facility opened its doors to patients in July 2015. "I don’t want to downplay the significance of the new hospital, but it’s really what we do inside of it and because of it that’s so important,” said Schor. “I look at the academic physicians and physician scientists who came to Rochester with just a dream and a fire in their belly and how they’ve now brought those dreams to fruition — that’s what I’m most proud of.”

The Department of Pediatrics grew from 110 faculty members to over 170 during Schor’s tenure, creating new divisions in palliative care, sleep medicine, allergy, and hospitalist medicine. Research centers focused on premature infants, translational molecular programs, and red blood cell development also developed under Schor’s leadership.

“Not only was the new hospital built under Nina’s leadership, but she truly championed the project, ensuring that every detail was designed with patients and families in mind,” said Mark Taubman, M.D., URMC CEO and Dean of the School of Medicine and Dentistry. “She has been the face of the children’s hospital and inspired trust in our families, physicians, and donors at a time when we very much needed the community’s support.”

Read More: Nina Schor to Step Down as Children's Hospital Pediatrician-in-Chief

Study Challenges Autism Brain Response Theory

Tuesday, December 6, 2016

A new study challenges the hypothesis that nerve cells in the brains of individuals with Autism Spectrum Disorders do not reliably and consistently respond to external stimuli. “Our findings show there is no measurable variation in how individuals with autism respond to repeated visual and tactile stimuli,” says senior author John Foxe, the Kilian J. and Caroline F. Schmitt Professor in Neuroscience.

Read More: Study Challenges Autism Brain Response Theory

New Biophysical Research Service Available

Friday, December 2, 2016

The University has purchased a J-1100 circular dichroism (CD) spectrometer from JASCO Inc. The shared-use instrument will be housed and maintained as part of the Structural Biology and Biophysics facility. Manager Jermaine Jenkins will maintain the instrument, as well as manage user time, train users, and assist with data collection and analysis as needed. Email Jermaine Jenkins, Ph.D. to plan your experiments.

Read More: New Biophysical Research Service Available

Helena Temkin-Greener, PhD was awarded a two-year research grant from the Donaghue Foundation

Thursday, December 1, 2016

Helena Temkin-Greener, PhD was awarded a two-year research grant from the Donaghue Foundation. The overall goal of the research project is to develop process and outcome-based measures of care quality for nursing home residents with mental health and behavioral disorders, and to explain variations in these measures across facilities and regions/states. Locally, findings will provide a benchmark performance measure for nursing homes participating in the NYS Delivery System Reform Incentive Payment (DSRIP) Program.

NIH Pre-Doctoral Fellowship Award

Tuesday, November 29, 2016

Matt Cavanaugh, a fifth year Neuroscience Graduate Program student in Dr. Krystel Huxlin’s lab was awarded an NIH Individual Pre-doctoral Fellowship from the National Eye Institute for his project entitled: Properties of training-induced visual recovery in cortical blindness (2016-2019).

Congratulations Matt!

Brain training video games help low-vision kids see better

Monday, November 28, 2016

Studies going back several years have shown that playing action video games (AVG) can help improve visual acuity. A new study by vision scientists at the University of Rochester and Vanderbilt University found that children with poor vision see vast improvement in their peripheral vision after only eight hours of training via kid-friendly video games. Most surprising to the scientists was the range of visual gains the children made, and that the gains were quickly acquired and stable when tested a year later.

“Children who have profound visual deficits often expend a disproportionate amount of effort trying to see straight ahead, and as a consequence they neglect their peripheral vision,” said Duje Tadin, associate professor of brain and cognitive sciences at Rochester. “This is problematic because visual periphery—which plays a critical role in mobility and other key visual functions—is often less affected by visual impairments.”

“We know that action video games (AVG) can improve visual perception, so we isolated the AVG components that we thought would have the strongest effect on perception and devised a kid-friendly game that compels players to pay attention to the entire visual field, not just where their vision is most impaired,” said Tadin, who is also a professor in the Center for Visual Science. “As a result, we’ve seen up to 50 percent improvement in visual perception tasks.”

Read More: Brain training video games help low-vision kids see better

Children’s Hospital Pediatrician-in-Chief Named Fellow of the AAAS

Monday, November 21, 2016

Nina Schor, M.D., Ph.D., William H. Eilinger Chair of Pediatrics and the pediatrician-in-chief at UR Medicine’s Golisano Children’s Hospital, has been named a Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society.

AAAS, which will publish the announcement on Nov. 25 in its journal Science, selects Fellows based on their scientifically and socially distinguished efforts to advance science or its applications. Schor has spent much of her career investigating neuroblastoma — which is among the most common childhood cancers — and was recognized for “her distinguished contributions to developmental neuroscience and neuropharmacology, particularly using molecular neuroscientific discoveries to design innovative therapies for tumors of the developing nervous system.”

Read More: Children’s Hospital Pediatrician-in-Chief Named Fellow of the AAAS

‘Antisense’ compounds offer new weapon against influenza A

Thursday, November 17, 2016

Challenging a long-held convention, University researchers have shown they can inhibit the influenza A virus by targeting its genomic RNA with “antisense” compounds.

Their findings, highlighted on the cover of Nucleic Acid Therapeutics, offer scientists a new way to attack an increasingly drug-resistant pathogen that causes an estimated 250,000 to 500,000 deaths a year.

“Antisense” compounds are synthesized with nucleotides, the building blocks of nucleic acid, often shown as various combinations of A, U, G and C. When the compounds – called antisense oligonucleotides (ASOs) – bind to the targeted genomic RNA, they block its ability to replicate.

The collaboration, involving the labs of Douglas Turner, professor of chemistry; Luis Martinez-Sobrido, associate professor of microbiology and immunology; and two researchers in Poland, reported that “antisense” compounds targeting one of the virus’ eight genomic RNA segments caused a five- to 25-fold reduction of influenza A virus in cell cultures.

“That’s a big difference,” Martinez-Sobrido says. “When mice are infected with 10,000 viruses, they all die. However, with 25 times less virus, all animals can survive infection and they don’t even develop symptoms.”

Read More: ‘Antisense’ compounds offer new weapon against influenza A

Wilmot Co-directors Honored with Davey Award

Tuesday, November 15, 2016

Land and Linehan

Hartmut “Hucky” Land, Ph.D. (left) and David C. Linehan, M.D.

Wilmot Cancer Institute’s co-directors Hartmut “Hucky” Land, Ph.D., and David C. Linehan, M.D., were recognized recently with the Davey Award, an honor bestowed on University of Rochester faculty members who have made outstanding contributions to cancer research.

They received their awards at the 21st annual Wilmot Scientific Symposium Nov. 10. The award for Land, who organizes the annual symposium, was a surprise orchestrated by Jonathan W. Friedberg, M.D., M.M.Sc., director of Wilmot Cancer Institute.

At the symposium, Land presented the planned Davey Award to Linehan, who is also Wilmot’s director of clinical operations and the Seymour I. Schwartz Professor and Chairman of Surgery. Linehan was recognized for his work studying the role of the tumor microenvironment in promoting treatment resistance in pancreatic cancer.

Before his lecture, Linehan presented Land the surprise award with a recorded video message from Friedberg. Land, who is also Wilmot’s director of research and the Robert and Dorothy Markin Professor of Biomedical Genetics, was recognized for his body of work and for his work studying the genetic programs that control all of cancer’s worst shared features — such as a cancer cell’s ability to quickly divide and survive despite aggressive treatment.

Repurposed Drug May Offer Diagnosis, Treatment for Traumatic Nerve Damage

Monday, November 14, 2016

Researchers at the University of Rochester Medical Center believe they have identified a new means of enhancing the body’s ability to repair its own cells, which they hope will lead to better diagnosis and treatment of traumatic nerve injuries, like those sustained in car accidents, sports injuries, or in combat. In a study published today, the team showed that a drug previously approved for other purposes can ‘wake up’ damaged peripheral nerves and speed repair and functional recovery after injury.

The study appearing in EMBO Molecular Medicine, demonstrates for the first time that 4-aminopyridine (4AP), a drug currently used to treat patients with the chronic nerve disease, multiple sclerosis, has the unexpected property of promoting recovery from acute nerve damage. Although this drug has been studied for over 30 years for its ability to treat chronic diseases, this is the first demonstration of 4AP’s benefit in treating acute nerve injury and the first time those benefits were shown to persist after treatment was stopped.

Study authors, John Elfar, M.D., associate professor of Orthopaedics, and Mark Noble, Ph.D., Martha M. Freeman, M.D., Professor in Biomedical Genetics, and their laboratory team, found that daily treatment with 4AP promotes repair of myelin, the insulating material that normally surrounds nerve fibers, in mice. When this insulation is damaged, as occurs in traumatic peripheral nerve injury, nerve cell function is impaired. These researchers found that 4AP treatment accelerates repair of myelin damage and improvement in nerve function.

Read More: Repurposed Drug May Offer Diagnosis, Treatment for Traumatic Nerve Damage

Catherine Ovitt Featured in D&C's Hot Jobs

Sunday, November 13, 2016

Land and Linehan

Dr. Catherine Ovitt

Salivary glands, which make as much as a quart of saliva each day, don’t pose a life-threatening risk if they stop working properly. But given their roles — they are important for swallowing, keep the inside of your mouth moist so your cheeks can move around, and have both anti-fungal and anti-bacterial properties — a malfunction would greatly impact quality of life.

Medical scientist Catherine Ovitt has dedicated her career to the study of salivary glands, in particular to establishing therapeutic strategies for their repair or regeneration after damage from radiation treatment due to head and neck cancers, or because of cellular damage from autoimmune diseases.

“A long-term goal would be to develop some sort of cell therapy treatment, some kind of transplantation or artificial salivary gland,” said Ovitt, who lives in Pittsford and is an associate professor in the Center for Oral Biology, part of UR Medicine’s Eastman Institute for Oral Health. Without the glands, she added, “you end up losing all your teeth.”

Read More: Catherine Ovitt Featured in D&C's Hot Jobs

Karl Smith Featured as Part of MAG Hidden Passions Series

Tuesday, November 8, 2016

Biophysics PhD candidate, Karl Smith, is giving a talk at the Memorial Art Gallery, this Thursday at 7pm as part of their Hidden Passions speaking series.

At URMC, Smith studies glass filters 10,000 times thinner than a human hair as part of the Nanomembranes Research Group. It’s because of his rigorous academic schedule that he began the 10-cent project.

The Pittsburgh native has written more than 900 stories, each roughly 500 words, on half sheets of paper. Strangers give him a prompt, and he pecks away. He’s crafted stories about lost loves, lost dogs, sea lions, flying princesses, and frogs who jump over the moon. Stories about babies, treehouses, aardvarks, and dancing polar bears. Stories about murder.

Read more about Karl and his passion.

Monique Mendes Accepted to SfN's Neuronline Community Leaders Program

Tuesday, November 1, 2016

NGP student, Monique Mendes, was recently accepted into the SfN's Neuronline Community Leaders Program. This was a highly competitive process where only 35 of the nearly 100 applicants. Neuronline Community Leaders will be vital players in sparking and guiding different conversations by sharing their knowledge and insights with others in the field of neuroscience. Through their expertise and experiences, Neuronline Community Leaders will help create meaningful discussion and contribute to members feeling connected and supported between annual SfN meetings — playing a key role in SfN’s organizational mission to host great venues where great science gets shared.

Congratulations Monique!!!

Read More: Monique Mendes Accepted to SfN's Neuronline Community Leaders Program

Thomas Mariani Authors Study on Infant Nose, Lung Cells

Thursday, October 13, 2016

Cells from an infant’s nose are remarkably similar to those found in the lungs, a discovery that could lead to much more precise diagnosis of respiratory syncytial virus (RSV) and other infant lung diseases, according to new URMC research.

The study, published in Scientific Reports, provides a potential avenue for diagnosis that has challenged physicians for years, as infants with respiratory disease are usually so fragile that attempting to obtain lung samples is unsafe. Nasal cells, however, can be captured through a simple swab of the nostril, and their similarity to lung cells on an RNA level would allow physicians to get an accurate representation of how the lung is responding during disease states, without the need for more invasive tests.

“An infant with RSV could potentially have their nasal cells tested to determine if they are among the small group that will develop a severe response that might require hospitalization,” said Thomas Mariani, Ph.D., professor of Pediatrics and the study’s lead author. “Additionally, we could potentially use this method to examine other at-risk infants, such as those born prematurely who face a greater risk for lung disease throughout life — and identify which of those children should be treated more aggressively.”

The research also carries tremendous promise for future studies. While scientists have made significant progress over the past several decades to better understand adult lung diseases — such as chronic obstructive pulmonary disease and lung fibrosis — discovery has not been nearly as robust for infant diseases, due to the risks involved in securing lung tissue.

But the relative ease of obtaining nasal cells could accelerate understanding of how infant lungs respond to RSV and other diseases. While this study examined 53 healthy infants as a means of establishing a benchmark for normal cell structure, researchers at URMC have already begun studying the nasal tissue of diseased infants. Early results are promising.

“We’re actively working on studies in infants with lung diseases, and we’re showing quite clearly that we can identify differences between those with mild disease and those with more severe outcomes,” Mariani said.

The research is conducted by URMC’s Respiratory Pathogens Research Center, which coordinates its work with the national Respiratory Pathogens Research Center established by the National Institute of Allergy and Infectious Diseases. The Center, under the direction of David Topham, Ph.D., focuses on research that will lead to a better understanding of the interactions between respiratory pathogens, the immune system, and other genetic and environmental factors.

ChinYi Chu, M.S., Xing Qiu, Ph.D., Lu Wang, M.S., Soumyaroop Bhattacharya, M.S., M.Ed., Gerry Lofthus, Ph.D., Anthony Corbett, M.S., Jeanne Holden-Wiltse, M.S., Alex Grier, M.S., Brenda Tesini, M.D., Steve Gill, Ph.D., Ann Falsey, M.D., Mary Caserta, M.D., and Ed Walsh, M.D., from the University of Rochester, contributed to these studies.

Read More: Thomas Mariani Authors Study on Infant Nose, Lung Cells

Research Will Explore New Therapies for Huntington's Disease

Wednesday, October 12, 2016

A new award from the CHDI Foundation will advance promising research that aims to slow the progression of Huntington’s disease. The funding, anticipated to total more than $10.5 million over next five years, will help University of Rochester Medical Center (URMC) scientists develop a stem cell-based therapy that swaps sick brain cells for healthy ones.

The new award will go to the lab of Steve Goldman, M.D., Ph.D., the co-director of the URMC Center for Translational Neuromedicine, which has research operations in both Rochester and at the University of Copenhagen.

Huntington’s is a hereditary neurodegenerative disease characterized by the loss of medium spiny neurons, a nerve cell in the brain that plays a critical role in motor control. As the disease progresses over time and more of these cells die, the result is involuntary movements, problems with coordination, and cognitive decline, depression, and often psychosis. There is currently no way to slow or modify this fatal disease.

The new award will support research that builds upon findings published by Goldman earlier this year in the journal Nature Communications showing that researchers were able to slow the progression of the disease in mice by transplanting healthy human support cells, called glial progenitor cells, into the animals’ brains.

Read More: Research Will Explore New Therapies for Huntington's Disease

Wilmot Scientists Exploit Cell Metabolism to Attack Cancer

Wednesday, October 12, 2016

Cancer cells have their own unique ways of reproducing, involving a shrewd metabolic reprograming that has been observed in virtually all types of cancer but not in normal cells. Now, University of Rochester Medical Center scientists have pinpointed one key source of the problem, which could lead to new treatment opportunities.

In an article published by Cell Reports, the scientific team shows for the first time how cancer-causing mutations control and alter the way cancer cells biosynthesize and replicate.

The discovery is the result of a close collaboration between the laboratories of Joshua Munger, Ph.D., associate professor of Biochemistry and Biophysics, and Hucky Land, Ph.D., the Robert and Dorothy Markin Professor and Chair of Biomedical Genetics and director of research at the URMC’s Wilmot Cancer Institute.

“Every tissue or cell type in the body has different metabolic needs but as cells become cancerous their metabolism shifts in ways that are very different from normal cells,” Munger said. “Being able to identify those differences is critical for developing treatment targets.”

Read More: Wilmot Scientists Exploit Cell Metabolism to Attack Cancer

Armond Collins Presents his work from Fudge Lab

Tuesday, October 11, 2016

Photo of Armond Collins
Photo of Armond Collins

Armond Collins, a second year medical student, presents the study he conducted with us this summer under the auspices of a Babigian Fellowship. Armond studied changes in myelination in amygdala and cortex of adult rats that had been exposed to 3 day bout of a repeated variable stressor during adolescence. His works follows up studies by Michele Saul, PhD that indicate that adolescent stress results in decreased oligodendrocyte precursors in the amygdala in the week following the stress.

NIH Director Visits URMC, Says it’s an Exciting Time to be a Researcher

Monday, October 10, 2016

NIH director round tableCollins’ first stop was lunch with 15 graduate students and postdocs who came prepared with a wide range of questions. The discussion covered the importance of communicating science to the public and policymakers, increasing diversity in biomedical research and new mechanisms to support young scientists at the start of their careers. Postdoctoral fellow Sarah Latchney and Ph.D. graduate student Solomon Abiola attended the lunch with Collins and describe the experience here.

Members of the Center for RNA Biology highlighted their most promising work for Collins and Center director Lynne E. Maquat, Ph.D., gave Collins a tour of her lab, where he met more trainees and junior researchers (admittedly, Collins’ favorite part of visits like these).

Dr. Collins SpeakingIn his keynote address at the end of the day, Collins delivered an uplifting message to a packed house in the Class of ’62 auditorium: it is an extremely exciting time to be in biomedical research, and after many lean years we are turning a corner, with the NIH budget finally increasing in real terms. He detailed several of the NIH’s new programs, like the Human Microbiome Project, Big Data to Knowledge (BD2K), the Precision Medicine Initiative and the Cancer Moonshot.

He applauded URMC on the renewal of the CTSI funding and cited the translational research conducted by Arthur J. Moss, M.D., which has led to new treatments for patients with Long QT syndrome (LQTS), and John J. Treanor, M.D., which is helping scientists in pursuit of a universal flu vaccine. Collins outlined several new funding initiatives, including the NIH Director’s Early Independence Award, which is helping assistant professor Elaine L. Hill, Ph.D., study the impact of fracking on infant and child health.

Collins affirmed that the U.S. is the strongest biomedical research country in the world thanks to institutions like URMC. You can view his keynote, “Exceptional Opportunities in Biomedical Research,” here.

Read More: NIH Director Visits URMC, Says it’s an Exciting Time to be a Researcher

New Grants Explore Role of Brain’s “Garbage Truck” in Mini-Stokes and Trauma

Wednesday, October 5, 2016

Photo of Dr. Nedergaard

Maiken Nedergaard, M.D., D.M.Sc.

More than $4.5 million in new grants to the lab of University of Rochester Medical Center scientist Maiken Nedergaard, M.D., D.M.Sc., underscore the important role the brain’s waste disposal system may play in a range of neurological disorders. The new awards will advance understanding of how small vessel disease and traumatic brain injury can give rise to cognitive and behavioral problems.

Nedergaard and her colleagues first unveiled the brain’s unique method of removing waste – dubbed the glymphatic system – in a paper in Science Translational Medicine in 2012. The research revealed that the brain possesses a circulation network that piggybacks on blood vessels and uses cerebral spinal fluid to flush away waste products from brain tissue. Since that time, the team has gone on to show that the glymphatic system works primarily while we sleep, could be a key player in diseases like Alzheimer’s, and is disrupted after traumatic brain injury.

Read More: New Grants Explore Role of Brain’s “Garbage Truck” in Mini-Stokes and Trauma

NGP Student Awarded NIH Fellowship

Monday, October 3, 2016

Photo of Rebecca Rausch

Rebecca Rausch, a fifth year neuroscience graduate student in Dr. Richard Libby’s lab was awarded an NIH Individual Pre-doctoral Fellowship from the National Eye Institute for her project entitled: The Role of Notch and BMP Signaling in Anterior Segment Dysgenesis (2016-2019).

Congratulations Becca!

Nuclear Protein Causes Neuroblastoma to Become More Aggressive

Wednesday, September 28, 2016

Image of Photoblastomas

Aggressive forms of neuroblastoma contain a specific protein in their cells’ nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center (URMC), could lead to new forms of targeted therapy.

EYA1, a protein that contributes to ear development, is present in the cytoplasm of many neuroblastoma tumors, but this protein migrates to the nucleus in the cells of more aggressive forms of the disease. The research, recently published in two medical research journals, allows for the development of targeted drugs that will work to prevent the neuroblastoma from reaching this more aggressive stage; researchers at URMC and elsewhere have already begun testing some of these potential treatments in a laboratory setting.

Photo of Nina Schor

“Neuroblastoma is one of the most common and deadly forms of childhood cancer, and this discovery allows us to identify drugs that prevent the change in EYA1 structure and potentially minimize the danger to a child who has this disease,” said Nina Schor, M.D., Ph.D., professor of Pediatrics and Neuroscience and the William H. Eilinger Chair of Pediatrics at URMC.

Read More: Nuclear Protein Causes Neuroblastoma to Become More Aggressive

URMC Researchers Discover Rare Flu-Thwarting Mutation

Wednesday, September 28, 2016

A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body’s immune system. This University of Rochester Medical Center discovery could provide a new strategy for live influenza vaccines in the future.

A new approach to the live flu vaccine would be particularly advantageous right now after the Centers for Disease Control and Prevention stopped recommending use of the live attenuate flu vaccine, FluMist® earlier this year. Several studies found that the pain-free nasal spray, which was used in about one-third of young children in the U.S., offered no protection to that especially vulnerable population. The flu shot, on the other hand, performed well and the CDC recommends using this vaccine in place of FluMist®.

“There is a need to understand what's happening with the existing live vaccine and potentially a need to develop a new one,” said David Topham, Ph.D., Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Microbiology and Immunology at URMC and author of the study. “We proposed that the mutation we found could be used to create a live vaccine.”

Read More: URMC Researchers Discover Rare Flu-Thwarting Mutation

Jessica Cantlon Named One of 10 Scientists to Watch by Science News

Friday, September 23, 2016

Photo of Jessica Cantlon

Jessica Cantlon

Jessica Cantlon, associate professor of Brain and Cognitive Sciences, was selected by Science News as one of their 10 early- to mid-career scientists to watch. Cantlon’s work centers on how human and nonhuman primates distinguish between quantities. Understanding how the brain makes sense of concepts such as estimating quantities and counting might lead to better ways of teaching numerical concepts to children.

Read More: Jessica Cantlon Named One of 10 Scientists to Watch by Science News

American Health Council Names Dr. Harold Smith, Ph.D. to Education Board

Monday, September 19, 2016

Dr. Harold Smith, Professor at The University of Rochester, has been selected to join the Education Board at the American Health Council. Dr. Smith will be sharing his knowledge and expertise in the field of molecular biology, molecular virology, RNA biology, and drug discovery.

Dr. Harold Smith became involved in research after beginning his career as a professor in the Department of Biochemistry at The University of Rochester. As a biophysics professor, he utilized his knowledge and expertise in the areas of research and innovation of RNA, protein molecular biology, cell regulation, and drug discovery. Furthermore, Dr. Smith develops curriculum, teaches and mentors students from high school to postgraduate.

Dr. Harold Smith is also the Founder, President, and CEO of OyaGen, Inc. The objective of OyaGen, Inc. is to induce transient and beneficial changes in the protein expression and function in human tissues by involving the editing enzymes in targeting biomedically relevant pathways.

Dr. Harold Smith is a member of The American Heart Association, The Council on Atherosclerosis, The RNA Society, The American Society for Biochemistry and Molecular Biology and a fellow in the The Royal Society of Biology. In addition, Dr. Smith serves on the Scientific Advisor Board of Cannabis Sciences, Inc., IgxBio, Inc. and Trovita Health Sciences as well as the Editorial Board of the International Journal of Virology and AIDS, Frontiers in Microbiology, The Journal of Biological Chemistry, and The Journal of BioDiscovery.

Read More: American Health Council Names Dr. Harold Smith, Ph.D. to Education Board

Miller Receives Patent for Technology that Can Help Detect Flu

Thursday, September 15, 2016

Benjamin L. Miller, Ph.D., professor of Dermatology, recently received yet another patent for a new technology that can detect miniscule amounts of specific molecules in blood or other liquids. The patent focuses on using this technology to make detecting immune responses to the flu quicker and easier.

The AIR™ Platform, marketed by Adarza Biosystems, can detect immune responses to flu vaccines as well as the virus itself. With a small blood sample from a patient, doctors can confirm a flu infection, see if the patient mounts an appropriate immune response to a vaccine, or see if immune responses cross react with several different strains of flu. AIR™ can also be used for viral surveillance.

While Miller’s AIR™ system is not the first to make these things possible, it is a great improvement on previous technologies. Its silicon chip, which is only about the size of the end of a pencil eraser, allows scientists to detect hundreds of different target molecules in a single drop of fluid, and its “label-free” design requires fewer steps and reagents, thus reducing cost and opportunities for error.

“Label-free” systems suppress background noise to detect tiny signals, whereas conventional “labeled” systems use a more cumbersome design to amplify a tiny signal, often creating a lot of background noise in the process.

“It’s like walking through a city during the day and looking up at the buildings,” Miller said. “You have no idea what's going on in the offices because there's so much ambient light, but if you come back at night, it's easy to see.”

Miller suppresses background noise using a near-perfect anti-reflective coating on his silicon chips. For every 100 million photons of light that hit the surface of the chip, only one photon is reflected back. That coating also contains capture molecules meant to bind or “capture” specific target molecules, like antibodies produced in response to the flu virus. The more antibodies that bind to the chip, the more the anti-reflective coating is perturbed, and the more light is reflected and captured by a camera.

This simple and unconventional design and the ability to use capture molecules both big and small makes AIR™ extremely versatile. From cancer and infectious diseases, to agriculture and food safety, AIR™ is poised to expedite research and clinical testing across a wide range of applications.

Haber, Farrar Receive Awards

Tuesday, September 13, 2016

Suzanne N. Haber, Ph.D., has been awarded a NIH R13 Conference grant. On October 11-13, 2016, the University of Rochester Institute of Neuromedicine and the Silvio O. Conte Center will hold a meeting entitled “Persistent, maladaptive behaviors: why we make bad choices”. The program is designed to involve basic and clinical scientists with a specific focus on the fundamental elements that drive basic behaviors and action plans (reward, fear, and value assignment); circuit dysfunctions that underlie abnormalities in diseases with persistent, habit-like behaviors, despite some awareness that these behaviors are maladaptive; the circuit components that are common amongst diseases; computational approaches to understanding these circuits; and therapeutic approaches that effect these circuits.

Christopher Farrar, a Ph.D. candidate in the lab of Professor Denise Hocking, has been awarded a Ruth L. Kirschstein National Research Service Award (NIH-NRSA) Individual Predoctoral Fellowship (F31) from the National Heart, Lung, and Blood Institute for his project entitled “Influence of Extracellular Matrix Fibronectin on Platelet-Derived Growth Factor (PDGF) Signaling”. PDGF is produced by a variety of different cell types and stimulates mesenchymal cell proliferation, migration, and gene expression. Together with fibronectin, PDGF plays an important role in angiogenesis and wound repair. In contrast, excess PDGF and abnormal fibronectin matrix deposition are linked to several diseases, including pulmonary fibrosis, atherosclerosis, and certain cancers. The focus of Chris’ project is to determine how mesenchymal cell adhesion to extracellular matrix fibronectin fibrils influences the ability of these cells to respond to PDGF, with the long-term goal of developing new treatment approaches to effectively regulate the sensitivity of cells to growth factor stimulation.

Harris Gelbard Receives International Award for Neurovirology Research

Tuesday, September 13, 2016

Harris GelbardHarris “Handy” Gelbard, M.D., Ph.D., director of the Center for Neural Development & Disease, is slated to receive the Hilary Koprowski Prize in Neurovirology at this year’s International Symposium on Molecular Medicine and Infectious Disease at Drexel University. Gelbard will be recognized for developing an unconventional drug that shows promise in treating brain disorders associated with HIV.

Gelbard’s drug, URMC-099, calms the immune system when it goes awry, as happens in HIV Associated Neurocognitive Disorder (HAND). In HAND, immune reactions to HIV particles in the brain damage nerve cells and cause dementia. Because patients affected by HAND also have HIV, it was imperative that URMC-099 not interfere with the antiretroviral drugs that keep HIV-positive patients alive.

KL2 award helps researcher pave his career path

Friday, September 9, 2016

David Auerbach

David Auerbach, senior instructor in medicine,
says his KL2 award has "opened many doors for me."

David Auerbach's interest in pursuing a scientific career began during a hockey game his first year of college, when a teammate — who turned out to be a chief medical examiner — asked Auerbach if he would like to observe a case.

Now Auerbach's career is taking a major step forward with a two-year KL2 Mentored Career Development Program award from the University's Clinical and Translational Science Institute.

"It has opened up many doors for me," says Auerbach, including lead authorship of a recent paper in Neurology.

Auerbach, a senior instructor in the Department of Medicine/Aab Cardiovascular Research Institute, is taking a multisystem approach to understanding the mechanisms that cause electrical disturbances in both the hearts and brains of patients with genetic ion channel diseases. Ion channels, located in the plasma membrane of cells, are narrow tunnels that open and close at precise times to allow the flow of ions into or out of the cell, thus shaping the electrical activity in the heart and brain.

As a postdoc working with Lori Isom, a professor at the University of Michigan, Auerbach demonstrated that people with severe genetic forms of epilepsy were at a higher risk not only of electrical disturbances in the brain, resulting in seizures, but also of electrical disturbances in the heart, causing arrhythmias.

In order to establish an independent line of research, Auerbach decided to approach the problem in reverse: are people with long QT syndrome — a classically studied genetic cardiac disease that causes arrhythmias — also at an increased risk of seizures?

He came to Rochester in 2014 specifically because of its research strengths in this area, including the opportunity to work with such experts as Arthur Moss, the Bradford Berk Distinguished Professor of Medicine; Robert Dirksen, the Lewis Pratt Ross Professor and chair of pharmacology and physiology; and Charles Lowenstein, chief of cardiology and director of the Aab Cardiovascular Research Institute.

Read More: KL2 award helps researcher pave his career path

2016 Convocation Award Winners from Neuroscience

Thursday, September 8, 2016

Congratulations to the following people for winning teaching and student achievement awards at this year's SMD Opening Convocation.

Faculty Teaching, Mentoring & Diversity Awards

  • Deborah Cory-Slechta, PhD
  • John Olschowka, PhD

Medical & Graduate Student Achievement Awards

  • Alexandra McHale - Irving L. Spar Fellowship Award
  • Gavin Jenkins - Merritt and Marjorie Cleveland Fellowship
  • Neal Shah - J. Newell Stannard Graduate Student Scholarship Award
  • Grayson Sipe - Outstanding Student Mentor Award

Make sure to congratulate each of them when you see them.

Ann M. Dozier, PhD named Albert David Kaiser Chair of Public Health Sciences

Thursday, September 8, 2016

Ann M. Dozier, PhD, Professor Public Health Sciences, in the Center for Community Health, and of Clinical Nursing, named Albert David Kaiser Chair of Public Health Sciences at the Opening Convocation for the School of Medicine & Dentistry on September 8, 2016.

DOD Grant Explores New Drugs to Thwart Impact of Trauma, Stroke, and Cardiac Arrest

Thursday, September 8, 2016

Photo of soldier in desert

A $2.3 million Department of Defense grant will help neuroscientists develop new treatments for the emergency room and the battlefield. The research will focus on the development of new therapies that could help protect brain and other at risk organs following a trauma, heart attack, or stroke.

“While we have made significant progress in our ability to restore blood flow after stroke or cardiac arrest, the medical community does not have drugs at its disposal to prevent the secondary damage that occurs after these events,” said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. “This grant will further our research on a promising class of drugs that possess both anti-inflammatory and cytoprotective properties that we believe will be suitable for use in both military and emergency conditions.”

Read More: DOD Grant Explores New Drugs to Thwart Impact of Trauma, Stroke, and Cardiac Arrest

Kelly Thevenet-Morrison, M.S. awarded Outstanding Graduate Student Teacher award

Thursday, September 8, 2016

Kelly Thevenet-Morrison, M.S., Lead Programmer Analyst in the Department of Public Health Sciences, awarded Outstanding Graduate Student Teacher award at the Opening Convocation for the School of Medicine & Dentistry on September 8, 2016.

Anna Bird Receives Two Awards

Sunday, September 4, 2016

Anna Bird has received the Elkes Foundation Scholarship ($1200 in travel funds to the Keystone Symposium in Stockholm, Sweden) and the American Association of Immunologists (AAI) Trainee Abstract Award ($750 in travel funds for AAI Conference, Seattle 2016).

Automatic cortical representation of auditory pitch changes in Rett syndrome - John Foxe et al.

Thursday, September 1, 2016

Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones.

Read More: Automatic cortical representation of auditory pitch changes in Rett syndrome - John Foxe et al.

Hayley Martin, MD-PhD student in Epidemiology receives student scholarship

Thursday, September 1, 2016

Hayley Martin, MD-PhD student in Epidemiology received a student scholarship to attend the 2016 Family Medicine Education Consortium Annual Meeting in Pittsburgh, PA. This meeting is aimed at family medicine physicians, residents and medical students in the north east interested in "improving the health of the community by strengthening Family Medicine / Primary Care services and medical education.

Biochemistry & Biophysics Faculty Member and Photojournalist Barry Goldstein Covers Republican National Convention for The American Scholar

Wednesday, August 31, 2016

Barry Goldstein is a photographer specializing in portraiture and documentary themes. Originally trained as a physician and biophysicist, he is Associate Professor of Medical Humanities at the University of Rochester Medical Center, Visiting Professor of Humanities at Williams College, and Adjunct Professor of Humanism in Medicine at the NYU Medical School. He was the first Artist-in-Residence at the New York University Medical School on September 11, 2001, an experience that led to his collection Being There: Medical Student Morgue Volunteers Following 9/11. His most recent book, Gray Land: Soldiers on War, is a collection of portraits of, and interviews with soldiers in Iraq and at home. He lectures and exhibits widely, and is a recipient of a Massachusetts Cultural Council Artists Grant in Photography.

Most recently, Barry provided coverage of the Republication National Convention for the American Scholar. His RNC work can be seen at The American Scholar and on his website.

Heilbronner and Yule Receive Awards at 2016 Convocation

Monday, August 29, 2016

Sarah R. Heilbronner, PhD, will receive the Postdoctoral Achievement Award at the 2016 Convocation, on September 8. She is currently a postdoc in Dr. Suzanne Haber's lab, where she is studying the neural circuitry associated with reward processing, decision-making, and executive function.

Along with the other members of Dr. Haber's team, Sarah is working to determine the anatomical connections that are affected by neurosurgical interventions for psychiatric disorders (such as deep brain stimulation).

Professor David I. Yule, Ph.D., will also receive the Faculty Teaching Award, specifically the Trainee Academic Mentoring Award in Basic Science, as well as the Louis C. Lasagna Endowed Professorship at convocation. The Yule Lab studies intracellular calcium signaling in cells which are typically, electrically non-excitable. In cells such as the liver, exocrine, pancreas, salivary glands and various cells in the blood, increases in intracellular calcium are fundamentally important for diverse processes including secretion of digestive enzymes and fluid, glucose metabolism together with cellular growth and differentiation.

Congrats Sarah and David!

Dr. Diana Fernandez assumes co-chair position of the Latino Health Coalition

Monday, August 15, 2016

Dr. Diana Fernandez, Associate Professor of Public Health Sciences, is assuming the co-chair position of the Latino Health Coalition convened by the Finger Lakes Health Systems Agency

Blanton Tolbert Wins Morton L. Mandel Award For Outstanding Chemistry Faculty

Tuesday, August 9, 2016

Photo of Blanton Tolbert

Blanton Tolbert

Former Biophysics student, Blanton Tolbert (PhD 2006), mentored by Doug Turner & Ravi Basavappa, has been awarded the Morton L. Mandel endows award for outstanding chemistry faculty members at Case Western Reserve University.

Associate Professor Blanton S. Tolbert, whose work focuses closely on elucidating molecular details of the human immunodeficiency virus, more commonly known as HIV. A member of the Case Western Reserve faculty since 2012, Tolbert paired the honor with extraordinary achievements during the past academic year:

  • A featured cover story in the Journal of Molecular Biology that described new three-dimensional structures of molecules in the life cycle of HIV
  • A second article about HIV’s molecular structures, published in the Journal of Biological Chemistry that became the journal’s most-viewed RNA (Ribonucleic acid) paper in December 2015
  • Multiple online mentions of the work, including the Nov. 16 Science Highlights of the Advanced Photon Source at the U.S. Department of Energy’s Argonne National Library
  • Service as director of the chemistry department’s Research Experience for Undergraduates (REU) grant from the National Science Foundation. In that role, Tolbert led efforts that identified and recruited a diverse group of students to work on federally sponsored projects. As part of the 10-week experience learning cutting-edge science, the students also participated in teambuilding and professional development activities. The work proved so successful that one undergraduate was cited as co-author on a publication from his summer project.

Congratulations Blanton!

Read More: Blanton Tolbert Wins Morton L. Mandel Award For Outstanding Chemistry Faculty

How a Stone Spearhead Found in a Whale Could Help Solve the Mystery of Cancer

Monday, August 8, 2016

Bowhead whales can live over 200 years, but there is no evidence of a bowhead ever having cancer. "The biggest questions are what are the extra protections that whales have against cancer," says Vera Gorbunova, the Doris Johns Cherry Professor in the Department of Biology. "We would really like to understand the mechanism."

Read More: How a Stone Spearhead Found in a Whale Could Help Solve the Mystery of Cancer

Lin Honored as 'Brilliant New Investigator'

Thursday, August 4, 2016

Photo of Dr. LinUniversity of Rochester Assistant Professor of Nursing Feng (Vankee) Lin, Ph.D., R.N. will be presented with the Brilliant New Investigator Award from the Council for the Advancement of Nursing Science (CANS) at the organization’s 2016 State of the Science Congress on Nursing Research, Sept. 15-17 in Washington, D.C.

The award recognizes the contributions of scientists early in their research careers who show extraordinary potential to develop sustained programs of research certain to have significant impact on the science and practice of nursing and health care. Nominees must show a record of building research productivity in an area of major significance to nursing and health care, research dissemination and translation to practice and/or policy, and emerging leadership related to the advancement of nursing science.

Read More: Lin Honored as 'Brilliant New Investigator'

Pasternak Research Paper to be Published in J. Neuroscience

Thursday, August 4, 2016

Photo of Tania PasternakThe paper "Prefrontal Neurons Represent Motion Signals from Across the Visual Field but for Memory-Guided Comparisons Depend on Neurons Providing these Signals" will be published in J. Neuroscience shortly.

Visual decisions often involve comparisons of sequential visual motion that can appear at any location in the visual field. We show that during such comparisons, the lateral prefrontal cortex (LPFC) contains accurate representation of visual motion from across the visual field, supplied by motion processing neurons. However, at the time of comparison, LPFC neurons can only use this information to compute the differences between the stimuli, if stimuli appear at the same retinal location, implicating neurons with localized receptive fields in the comparison process. These findings show that sensory comparisons rely on the interactions between LPFC and sensory neurons that not only supply sensory signals but also actively participate in the comparison of these signals at the time of the decision.

Make sure to read the article when it comes out.

University of Rochester rising junior completes research project on infant feeding

Monday, August 1, 2016

Yareni Sime, a University of Rochester rising junior and Scholar in the Ronald E. McNair Post-Baccalaureate Achievement Program, was hosted this summer by Dr. Ann Dozier and her team that is studying infant feeding, health and safety. Ms. Sime's summer research project was entitled Suboptimal Infant Feeding Practices Among Hispanic/Latino Women in Monroe County.

Maquat Featured at Cornell-Ithaca Creativity Workshop

Saturday, July 30, 2016

RocHackHealth Group

J. Lowell Orbison Chair of Biochemistry and Biophysics, and of Oncology, Lynne Maquat, PhD, was a featured speaker at The Creativity Spark: a creativity workshop for scientists, a workshop put on by Cornell University, July 25.

The creativity workshop featured award winning scientists and scholars, including two Nobel Laureates, as they discussed the Creativity Spark and its role in science exploration.

Luebke and Bennetto Explore Hearing Test That May Identify Autism Risk

Monday, July 25, 2016

Diagram of hearing test to identify autism risk

Researchers have identified an inner ear deficiency in children with Autism that may impact their ability to recognize speech. The findings, which were published in the journal Autism Research, could ultimately be used as a way to identify children at risk for the disorder at an early age.

“This study identifies a simple, safe, and non-invasive method to screen young children for hearing deficits that are associated with Autism,” said Anne Luebke, Ph.D., an associate professor in the University of Rochester Medical Center Departments of Biomedical Engineering and Neuroscience and a co-author of the study. “This technique may provide clinicians a new window into the disorder and enable us to intervene earlier and help achieve optimal outcomes.”

“Auditory impairment has long been associated with developmental delay and other problems, such as language deficits,” said Loisa Bennetto, Ph.D., an associate professor in the University of Rochester Department of Clinical and Social Sciences in Psychology and a co-author of the study. “While there is no association between hearing problems and autism, difficulty in processing speech may contribute to some of the core symptoms of the disease. Early detection could help identify risk for ASD and enable clinicians to intervene earlier. Additionally, these findings can inform the development of approaches to correct auditory impairment with hearing aids or other devices that can improve the range of sounds the ear can process.”

Read More: Luebke and Bennetto Explore Hearing Test That May Identify Autism Risk

McNair Summer Scholar Ashley Bui Talks Amygdala Circuits

Friday, July 22, 2016

Photo of Ashley BuiCongratulations to Ashley Bui, a rising senior in Brain and Cognitive Sciences, on her presentation July 22, 2016. Her talk Projections from the Temporal Cortex to the Basal Nucleus of the Amygdala in the Macaque highlighted data from her summer project in our lab. The amygdala is required for computing which of the complex sensory stimuli that an individual encounters are emotionally meaningful, so that appropriate action can be taken. Ashley’s preliminary data shows that specific portions of the temporal cortex, which are critical for processing complex visual and auditory information, communicate with different regions of the amygdala. The results suggest that cortical areas that process complex visual information on 'what' and 'where' an object is (or is moving) are communicating with specific amygdala subregions. Thus, while determining the emotional importance of ‘what or who’ is important, biologic movements also likely influence amygdala activity and coding. We are happy that she will continue this work through the Fall semester.

NGP student plays with RPO

Thursday, July 21, 2016

Monique Mendes plays with RPO

Second year NGP student, Monique Mendes, had a unique opportunity to play alongside the Rochester Philharmonic Orchestra in their Side-by-Side Reading Session – a program that pairs amateur and professional musicians in a joint rehearsal and performance at Kodak Hall on July 21st.
Congratulations Monique!

Ryan Dawes defends thesis

Monday, July 18, 2016

Photo of Ryan Dawes

Ryan Dawes successfully defended his thesis, "β-Adrenergic Receptor Signaling Constrains Breast Cancer Progression and Modulates Tumor-Associated Exosome Content And Function" on July 18, 2016.

Congratulations Dr. Dawes!

Minsoo Kim Wins Dolph O. Adams Award

Friday, July 15, 2016

Congratulations to professor of Microbiology and Immunology and The Center for Vaccine Biology and Immunology, Minsoo Kim, who has won the 2016 Dolph O. Adams Award. Dr. Kim will be accepting the award at the SLB Annual Meeting in September in Verona Italy!

This annual award is named in honor of the outstanding macrophage researcher Dolph O. Adams, M.D., Ph.D. The award is to recognize excellence of an investigator working in the area of cellular and molecular mechanisms of host defense and inflammation.

Lisa A. DeLouise Receives Patent for Microfluidic Device

Friday, July 8, 2016

Lisa A. DeLouise, Ph.D., M.P.D., associate professor of Dermatology, Biomedical Engineering, Material Chemistry and Electrical and Computer Engineering and a member of the Environmental Health and Science Center, has received a patent for her microfluidic device and a method of manufacturing the device.

Research in the DeLouise Lab – funded by NYSTAR, NSF, DCFAR, CTSI and URVentures – has led to the development of a single cell screening technology platform based on microbubble well array. Single cell screening technologies can facilitate the discovery of rare cells.

DeLouise’s current work, in collaboration with James J. Kobie, Ph.D., assistant professor of Infectious Diseases, seeks to sort antigen-specific antibody-secreting B cells for the development of therapeutic monoclonal antibodies and the detection of cancer stem cells that harbor genetic mutations that confer their tumor-initiating and drug-resistant properties.

Meet Karl Smith, the Typewriting Tale Teller

Friday, July 8, 2016

Photo of Karl Smith

Karl Smith

The "Friends of Joe's Big Idea" is a vibrant community of talented people we think you should meet. With our feature, FOJBI Friday, we're introducing some of these cool communicators of science in their own words. This week: Karl Smith.

Background

I'm a fifth-year biophysics doctoral candidate at the University of Rochester, where I study porous ultrathin silicon membranes. At the moment I'm taking a brief break from my research to be an American Academy for the Advancement of Science Mass Media Fellow at the Manhattan office of Scientific American.

Importance of science communication

I love science communication because it's both hard and important. People need to be told what scientists have discovered and what it means for their lives, but to do that well requires balancing the storytelling needs of journalism against objectivity and sober contextualization. Also, I personally find scientists to be generally fascinating people to write about and hear from.

Current projects

Along with my co-producer Madeline Sofia, I created The Bench Warmer's Podcast, which tells stories of misadventures and victories in science using interviews with current and former graduate students. I think the stories that don't often get told about science — the scoops, the failures, the dead ends, rewrites and rejections — are just as important to tell as the wild success stories. Not only that, but I think we short-sell our successes by not highlighting how rare they are. So, in the podcast, Maddie and I ask questions like "What's the most expensive thing you ever broke in lab?" and "Have you ever embarrassed yourself by dislocating your knee while singing karaoke onstage in front of hundreds of your scientific peers and possible future employers?"

I also write "10-cent stories" for children at the Rochester Museum and Science Center and at a few other places around Rochester. The children give me a prompt and in five minutes I use my typewriter to type them a tale. I've been doing this for about three years now, and I've written well over 800 stories. Sometimes the stories have a STEM bend to them, but sometimes they're just stories. I love this project for a lot of reasons, but most of all because it lets me make the world a stranger, more whimsical place.

Future plans

I've only been at my fellowship for a few weeks, so I'm still deciding if I want to be a science journalist or if my plans lie elsewhere. This is a time of great flux for me, so I don't know yet where I'm heading. But I'm enjoying figuring it out.

Read More: Meet Karl Smith, the Typewriting Tale Teller

Rebecca Lowery Defends Thesis

Thursday, July 7, 2016

Rebecca Lowery and Ania Majewska

Rebecca Lowery has successfully defended her thesis, "The Role of Microglia and Fractalkine Signaling in Experience-dependent Synaptic Plasticity". Congratulate her when you see her.

Congratulations Dr. Lowery!

David Yule appointed Louis C. Lasagna Professor

Tuesday, July 5, 2016

David Yule sits in a lab

David Yule

David Yule, professor of pharmacology and physiology, has been appointed the Louis C. Lasagna Professor in Experimental Therapeutics for five years, effective July 1. He retains his joint appointments as professor of medicine and as professor in the Center for Oral Biology.

For the past 15 years, Yule has studied calcium’s role in disorders in which calcium signaling and secretions are disrupted, such as Sjögren’s syndrome—in which patients experience dry mouth due to a lack of saliva—and acute pancreatitis.

Using state-of-the art imaging and electrophysiological techniques, Yule’s lab monitors calcium signals to achieve a better understanding of the mechanisms that underlie these signals with the goal that the studies will give insight into the control of important physiological processes in both normal physiology and disease states.

Yule received his PhD in physiology from the University of Liverpool in the United Kingdom. His research has been published in numerous journals, including the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Science Signaling, and the Journal of Physiology. Yule serves on the editorial board for Gastroenterology, the preeminent journal in the field of gastrointestinal disease.

The Lasagna professorship honors Louis Lasagna, who served as chair of the Department for Pharmacology from 1970 to 1983, and brought the department to national recognition as a center of training and research. Lasagna, who was known for pioneering the study of placebos and writing an alternative Hippocratic oath, died in 2003.

Read More: David Yule appointed Louis C. Lasagna Professor

URMC Team Revises Understanding of Genetic Code

Friday, July 1, 2016

Grayhack lab photo

Beth Grayhack, Ph.D., with lab
members and grad students
Christina Brule and Jiyu Wang

Scientists for years have known that the genetic code found in all living things contains many layers of complexity. But new research from the University of Rochester cracks the code more deeply, clarifying for example why some genes are inefficiently translated into proteins.

In a study published in the journal Cell, the researchers, co-led by Beth Grayhack, Ph.D., of the UR School of Medicine and Dentistry, discovered the existence and identity of 17 pairs of inefficient codons (DNA nucleotides or bases) within the genetic code.

Scientists have generally considered each piece of the genetic code (or codon) as a single “word” in a language. But the new data suggests some codon combinations act as compound words or phrases whose order and pairing has a significant impact on the translation of genes into proteins.

“Consider the words ‘pancake’ versus ‘cake pan,’ “ said Grayhack, an associate professor of Biochemistry and Biophysics, Pediatrics, and Cancer, in the Center for RNA Biology, at the UR Medical Center.

Read More: URMC Team Revises Understanding of Genetic Code

The Sleep Hack Neuroscience Says Gives Your Brain Optimal Rest

Thursday, June 30, 2016

Sleep is critical for rest and rejuvenation. A human being will actually die of sleep deprivation before starvation--it takes about two weeks to starve, but only 10 days to die if you go without sleep.

The CDC has also classified insufficient sleep as a public health concern. Those who don't get enough sleep are more likely to suffer from chronic diseases that include hypertension, diabetes, depression, obesity, and cancer.

It's thus vital to get enough shuteye, but it turns out your sleep position also has a significant impact on the quality of rest you get.

Now, a neuroscience study suggests that of all sleep positions, one is most helpful when it comes to efficiently cleaning out waste from the brain: sleeping on your side.

The study, published in the Journal of Neuroscience, used dynamic contrast-enhanced MRI to image the brain's "glymphatic pathway." This is the system by which cerebrospinal fluid filters through the brain and swaps with interstitial fluid (the fluid around all other cells in the body).

"It is interesting that the lateral [side] sleep position is already the most popular in humans and most animals--even in the wild," said University of Rochester's Maiken Nedergaard. "It appears that we have adapted the lateral sleep position to most efficiently clear our brain of the metabolic waste products that build up while we are awake."

Read More: The Sleep Hack Neuroscience Says Gives Your Brain Optimal Rest

6th Annual Stem Cell and Regenerative Medicine Symposium

Monday, June 27, 2016

Dr. Jack Kessler

Dr. Jack Kessler

In celebration of the NYSTEM-funded training program in stem cell biology at the University of Rochester, researchers convened for a day of presentations and discussions on advances in stem cell biology.  To emphasize the excellence of our junior scientists, five NYSTEM trainees (both pre- and post-doctoral, took turns with leaders in the field of stem cell medicine to present their work. The meeting kicked off with a presentation by Dr. Jack Kessler, Northwestern University Feinberg School of Medicine) describing the factors controlling adult neural stem cell maintenance – a key determinant of cognitive health.

Dr. Kunle Odusi

Dr. Kunle Odusi

Dr. Angela Christiano(center)

Dr. Angela Christiano (center)

Dr. Kunle Odunsi (Roswell Park Cancer Institute) spoke in his role as director of the immune-therapy program on the importance of gene-engineered, tumor recognizing CD4 T-cells in anti-tumor therapy. 

Dr. Angela Christiano (Columbia University) provided an impressive example of the power of iPSC technology with the development of 3D-skin tissue for treatment of such devastating skin diseases as epidermolysis bulbosa.

NYSTEM Trainees

NYSTEM Trainees

Presentations by NYSTEM trainees Fanju Meng (Biteau lab), Wenxuan Liu (Chakkalakal Lab), Michael Rudy (Mayer-Proschel Lab), Dr. Andrew Campbell (Proschel Labs), and Dr. Nicole Scott (Noble Lab) rounded out a day full of exciting new work that highlights the broad impact of stem cell biology on medicine today – and the success of the SCRMI training program. The meeting was buoyed by good vibes and food provided by the backdrop of the Rochester International Jazz Festival.

Congratulations To This Year’s Poster Prize Winners

Graduate Student Category

  • Zhonghe Ke, High Levels of Niche Ha of the NMR Mediates the Maintenance of LT-HSC by reducing ROS Levels, Gorbunova Lab
  • Jayme Olsen, Generation of Human Erythroblasts with Increased EX Vivo Self-Renewal, Palis Lab
  • Michael Trembley, Novel Mechanisms of the Epicardial-Derived Cell Mobilization, Small Lab

Postdoctoral Category

  • Pearl Quijada, Novel Mechanisms of Epicardium Dependent Cardiac Repair, Small Lab

Thank you to all participants for a great event. See you again in 2017!

Review: Giving Gene Editing Technology CRISPR-Cas9 a Boost

Thursday, June 23, 2016

A new gene editing technology called CRISPR-Cas9 has taken the scientific world by storm. It allows researchers to quickly and easily make changes to the DNA of humans, animals and plants. The hope is that CRISPR-Cas9 may be used in the future to eliminate or correct faulty genes that cause disease.DNA

In a recent issue of the journal Cell, Lynne E. Maquat, Ph.D. and Maximilian W. Popp, Ph.D. of the University of Rochester Center for RNA Biology describe how scientists can make this technology more efficient. Understanding the principles of nonsense-mediated mRNA decay (NMD), a cellular mechanism that Maquat discovered early in her career, will help anyone employing the technology achieve a better result – namely, a more complete knock out or deletion of a desired gene.

Read More: Review: Giving Gene Editing Technology CRISPR-Cas9 a Boost

Catherine Ovitt receives 2016 IADR Innovation in Oral Care Award

Wednesday, June 22, 2016

Ovitt Award

Catherine Ovitt is one of this year’s three recipients of the 2016 IADR Innovation in Oral Care Awards. She accepted the award from IADR President Dr. Marc Heft at the IADR/APR General Session & Exhibition in Seoul, Republic of Korea. The three prestigious awards recognize research in innovative oral care technologies that may maintain and improve oral health, and are supported by GlaxoSmithKline.

Read More: Catherine Ovitt receives 2016 IADR Innovation in Oral Care Award

Elissa Wong receives Neuman Scholarship Award

Tuesday, June 21, 2016

Elissa Wong being presented with the Newman Award

Elissa Wong, a fifth year toxicology graduate student in Ania Majewska’s lab, received the Margaret and William F. Neuman Scholarship Award in Environmental Medicine for exemplary scholarship and citizenship. Dr. William Neuman was the chair of the Department of Radiation Biology and Biophysics for many years and helped to create the Toxicology Training Program and the Environmental Health Science Center. Dr. Margaret Neuman received her PhD in Biochemistry from the University of Rochester. Later, working here, she researched the effects of uranium on bone biochemistry, and was an expert on the regulation of bone minerals.

The criteria for receiving this are as follows: 1) scholarship, 2) scientific excellence, 3) productivity, and 4) exceptional citizenship to the field of toxicology.

Congratulations Elissa!

Claire McCarthy Wins Travel Award

Monday, June 13, 2016

Congratulations to Claire McCarthy, the newest recipient of the Medical Faculty Council UR-SMD Trainee/Student Travel Award for Spring 2016.

Clara Kielkopf Receives EvansMDS Discovery Research Grant

Saturday, June 11, 2016

Biochemistry & Biophysics Associate Professor, Clara Kielkopf's project, entitled, Structural mechanisms and targeting of MOS-relevant pre-mRNA splicing factors has been selected by EvansMDS for funding for 2016. This year EvansMDS requested 12 full DRG proposals and were able to fund 6 of them. Their hope is that these findings will translate into improvements in therapy that can be delivered to MDS patients.

The Kielkopf lab investigates splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects and splice sites and their associated proteins as therapeutic targets.

Mallory Scott Selected for Summer Internship at Bayer Pharmaceuticals

Friday, June 10, 2016

Mallory Scott, Biophysics, Structural and Computational Biology PhD student, in the laboratory of Dr. Paul Kammermeier, has been selected for a summer internship at Bayer Pharmaceuticals in Whippany, NJ in Global Regulatory Affairs. Mallory will gain valuable work experience in the healthcare industry while working with regulatory professionals on various projects to learn about the role of regulatory affairs in drug development and product registration as well as the regulatory landscape. Mallory will be working in the Chemistry, Manufacturing and Controls (CMC) division. Her project is focused on quality by design in continuous manufacturing.

Swapping Sick for Healthy Brain Cells Slows Huntington’s Disease

Tuesday, June 7, 2016

Photo of Steven Goldman

Researchers have successfully reduced the symptoms and slowed the progression of Huntington’s disease in mice using healthy human brain cells. The findings, which were published today in the journal Nature Communications, could ultimately point to a new method to treat the disease.

The research entailed implanting the animals with human glia cells derived from stem cells. One of the roles of glia, an important support cell found in the brain, is to tend to the health of neurons and the study’s findings show that replacing sick mouse glia with healthy human cells blunted the progress of the disease and rescued nerve cells at risk of death.

“The role that glia cells play in the progression of Huntington’s disease has never really been explored,” said Steve Goldman, M.D., Ph.D., co-director of the University of Rochester Center for Translational Neuromedicine. “This study shows that these cells are not only important actors in the disease, but may also hold the key to new treatment strategies.”

Read More: Swapping Sick for Healthy Brain Cells Slows Huntington’s Disease

Harold Smith Publishes Commentary on RNA and DNA Editing

Sunday, June 5, 2016

Epigenetics is a popular, yet still mysterious concept in health and medicine. It’s the study of a variety of biological processes that alter the expression of our genes. Sometimes this involves modifying the structure of our chromosomes to mask or unmask genes, and other times the actual genetic code is changed in certain cells. Harold C. Smith, Ph.D., a longtime professor of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry has studied epigenetics in a research focus known as RNA and DNA editing since it was introduced two decades ago. He was invited to write a commentary on the progress and future of this research, published today in Trends in Biochemical Sciences, and answers a few questions about the subject.

Read More: Harold Smith Publishes Commentary on RNA and DNA Editing

Post-doctoral Fellow wins the 2016 Weiss Toxicology Scholar Award

Wednesday, June 1, 2016

Luisa Caetano-Davies

Dr. Luisa Caetano-Davies (Biomedical Genetics) was the postdoctoral winner of the third annual Weiss Toxicology Award. The award was created to strengthen training and research in the Toxicology Training Program by enhancing support of talented future leaders in the field of toxicology, particularly those with an interest in neurotoxicology. The award is presented annually to a meritorious trainee with an interest in Neurotoxicology. Dr. Caetano-Davies is member of the Proschel lab and is studying the effects of environmental toxicants on early stages of Parkinson Disease pathology, in particular with a focus on astrocyte dysfunction. Carolyn Klocke (Cory-Schlechta Lab) was the winner of the graduate student category. Congratulations!

2016 Graduating Class

Wednesday, June 1, 2016

We had 22 total graduates this year: 1 Epidemiology PHD, 17 Masters’ in Public Health, 3 Masters’ in Clinical Investigation and 1 Masters in Health Services Research and Policy. Congratulations to all of our graduates!

Read More: 2016 Graduating Class

Dr. Michael Nussenzweig Gives Melville A. Hare Lecture

Monday, May 30, 2016

Photo of Dr. Michael Nussenzweig with award Michael Nussenzweig, M.D., Ph.D. gave the Melville Hare Memorial Lecture on May 12. The lecture, "The HIV Vaccine Problem" was organized by the students of the Department of Microbiology and Immunology and co-sponsored by the University of Rochester Center for AIDS Research.

GDSC Graduate Nirmalya Chatterjee reports a novel role of Bet proteins in the control of the oxidative stress response pathway.

Friday, May 27, 2016

Bet proteins are a subclass of bromodomain containing epigenetic “readers”. These proteins have complex and incompletely understood functions in the control of gene expression and chromatin organization. The human Bet proteins Brd3 and Brd4 have been implicated in cancer and thanks to the availability of specific inhibitors, have emerged as promising drug targets. The paper by Nirmalya Chatterjee, Min Tian and others describes experiments in Drosophila that discovered a novel function for Bet proteins: the regulation of the transcription factor Nrf2. The reported data show that a Drosophila Bet protein is part of a previously unknown pathway that can control Nrf2 activity. This is of interest as Nrf2 plays a prominent role in the defense against oxidative stress, protection against various diseases, and aging. Nirmalya Chatterjee, a recent member of the Bohmann Lab, received the PhD last September and is currently working as a postdoc in the group of Norbert Perrimon at Harvard Medical School.

Nirmalya Chatterjee2, Min Tian3, M., Kerstin Spirohn, Michael Boutros & Dirk Bohmann (2016) Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein, PLoS Genetics, will go to press 5/27/2016. PMID: 27233051

Congratulations to all of our Retreat awards winners

Thursday, May 26, 2016

The Toxicology program would like to congratulate the following on their 2016 Retreat awards:

  • Elissa Wong won the William F. and Margaret W. Neuman Award for exemplary scholarship and citizenship in the Toxicology Training Program
  • Amanda Croasdell won the (student) Robert F. Infurna Award for publishing the best research paper in toxicology (this award was started in 1998)
  • Lisbeth Boule won the (postdoc) Robert F. Infurna Award for publishing the best research paper in toxicology (this award was started in 1998)
  • Carolyn Klocke won the (student) Weiss Toxicology Scholar Award
  • Luisa Caetano-Davies won the (Postdoc) Weiss Toxicology Scholar Award

Luisa Caetano-Davies wins “Best Oral Presentation” Award.

Thursday, May 26, 2016

Luisa Caetano-Davies

Luisa Caetano-Davies

Luisa, a post-doctoral fellow in the Proschel Lab, received the award for her presentation on “Astrocyte dysfunction in Parkinson Disease” at the 2016 Environmental Medicine and Toxicology Training Program retreat. Her presentation described the use of both iPSC-based disease-in-a-dish and in vivo animal models to identify early astrocyte defects in PD disease etiology. Congratulations, Luisa!

Congratulations Karl Smith, AAAS Mass Media Fellowship Recipient

Monday, May 23, 2016

Karl Smith, 5th year graduate student in the Biophysics Structural and Computational Biology PhD program, laboratory of Dr. Jim McGrath, has received an AAAS (American Association for the Advancement of Science) Mass Media Fellowship. Karl, sponsored by the American Physical Society, will be spending 10 weeks this summer working at Scientific American in their Manhattan offices as part of his fellowship.

Since its inception, the AAAS Fellowship Program has supported more than 625 student scientists, engineers and medical professionals who, in some cases, produced the only original science-news reporting at their assigned media outlets over the summer. The current 15 fellows, selected from a pool of 130 outstanding applicants, are likely to generate between 200 and 300 original science stories for print articles, blogs, podcasts, radio segments, and multimedia features.

Past participants in the Mass Media Fellows program include Mark Dumont, Professor, Department of Biochemistry and Biophysics, who received the AAAS Mass Media Fellowship in 1975, the second year that it was in existence. Over that summer, he wrote 26 news articles for the San Diego Union.

Other recipients include Erica Goode and Kenneth Chang of the New York Times; Richard Harris, David Kestenbaum, and Joe Palca of NPR; renowned biologist Eric Lander, co-chair of U.S. President Barack Obama's Council of Advisors on Science and Technology; physician and "Law & Order: Special Victims Unit" Executive Producer Neal Baer; Victoria Bruce, author of No Apparent Danger: The True Story of Volcanic Disaster at Galeras and Nevado Del Ruiz; and many others. - from AAAS's website.

GDSC Student Xuan Li publishes on the role of Cdk12 in response to stress.

Monday, May 23, 2016

Xuan Li

Xuan Li

The phosphorylation of RNA polymerase II in the C-terminal domain, or CTD, is an essential step for the transcription of all eukaryotic protein coding genes. The paper be Xuan Li and colleagues describes the unexpected discovery that a certain CTD kinase, called CDK12, is not universally required, but is only needed for the transcription of genes that are inducible by stress, such as heat, DNA damage or reactive oxygen species. This finding suggests that CTD phosphorylation plays a role in the regulation of specific gene expression programs, rather than being a generic step of transcription. This work involved a large-scale robotic RNAi screen in collaboration with the Boutros lab in Heidelberg, as well as genetic and biochemical experiments in the Drosophila model system. Xuan Li, a graduate student in the Bohmann Lab is currently doing an internship at Takeda Pharmaceuticals in Boston and will defend her PhD in November.

Xuan Li1, Nirmalya Chatterjee2,, Kerstin Spirohn, Michael Boutros & Dirk Bohmann (2016) Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Scientific Reports, 6:21455. PMID: 26911346

Proposal by Amy Kiernan Receives University Research Award

Monday, May 23, 2016

A collaborative project involving Associate Professor Amy Kiernan of the Flaum Eye Institute has been chosen as one of the 2016-17 University Research Awards. One of just eight applications chosen by senior research leadership, the proposal entitled, "Understanding cell turnover and injury recovery in the corneal endothelium” will be funded $75.000 annually.

Conventional Radiation Therapy May Not Protect Healthy Brain Cells

Wednesday, May 18, 2016

Photo demo of conventional radiation therapy

A new study shows that repeated radiation therapy used to target tumors in the brain may not be as safe to healthy brain cells as previously assumed. The findings, which appear in the International Journal of Radiation Oncology, Biology, Physics, show that the treatment also kills important support cells in the brain and may cause as much, if not more damage, than single dose radiation therapy.

“This study suggests that conventional repeated radiation treatments offer no significant benefit to brain tumor patients,” said Kerry O’Banion, M.D., Ph.D., a professor in the University of Rochester Medical Center (URMC) Department of Neuroscience and lead author of the study. “It also shows that certain cell populations in the brain are vulnerable to radiation and this may help explain why so many brain cancer patients experience cognitive problems after treatment.”

Read More: Conventional Radiation Therapy May Not Protect Healthy Brain Cells

Karl Smith places third in University’s Falling Walls Competition

Wednesday, May 18, 2016

Karl Smith, a PhD student in Biophysics and a member of the lab of James McGrath, Professor of Biomedical Engineering, won third place in the University of Rochester’s Falling Walls Competition for describing his use of physics to make water behind a filter form a mixer vortex, reducing the difficulty of normal stirring when fluids stick to surfaces. A total of 19 presenters competed.

The competition is associated with the Falling Walls foundation, a non-profit organization that fosters discussions on research and innovation and promotes the latest scientific findings to society. The Rochester winner’s idea will compete with others from around the world at the Falling Walls Lab Finale in November in Berlin. This event selects the participants for the annual Falling Walls Conference the following day: an international forum for science and innovation to commemorate the fall of the Berlin Wall. Speakers at the conference have included Angela Merkel, Chancellor of Germany; Nobel Prize winner Sir Paul Nurse; and young inventors from around the world. BBC London said it was where the “brightest minds on the planet” meet.

Last year’s Falling Walls Lab Rochester winner, Ryan Trombetta, a BME PhD student in Dr. Awad’s lab, finished 12th (out off a 100 finalists worldwide) in the Berlin competition for his description of using 3D printed bone grafts to treat osteomyelitis. See his presentation here.

Solomon Abiola, Sara Nowacki and Karl Smith, the top three finishers at the Falling Walls Competition.

From left to right, Solomon Abiola, Sara Nowacki and Karl Smith, the top three finishers at the Falling Walls Competition.

Cindy (Xiaowen) Wang in the Noble Lab wins 2016 GSS Poster Prize

Tuesday, May 17, 2016

Cindy WangCindy (Xiaowen) Wang in the Noble Lab wins 2016 GSS Poster Prize with her work on: Identifying c-Cbl as a critical point of intervention in acquired tamoxifen resistant breast cancer. (Co-authors Jennifer L Stripay, Hsing-Yu Chen and Mark D Noble).

Garry Coles wins 2016 Vincent du Vigneaud Award For Excellence in Graduate Research

Tuesday, May 17, 2016

Garry ColesGarry Coles, graduate of the Genetics, Development and Stem Cell program received this years du Vigneaud commencement award. The University of Rochester School of Medicine and Dentistry recognizes outstanding post-baccalaureate research efforts and promising PhD candidates through the Vincent du Vigneaud Award, in honor of Vincent du Vigneaud, himself a PhD graduate of the University of Rochester and recipient of the 1955 Nobel Prize in Chemistry.

Gary's PhD thesis, entitled "KIF7 and microtubule dynamics function to regulate cellular proliferation and cell cycle progression" focuses on deciphering the role of Kinesin family member 7 (Kif7) on cell cycle control during mammalian development. The work was conducted in Dr. Kate Ackerman's laboratory and has been published in the Proceedings of National Academy of Sciences (PNAS), PLoS Genetics and Developmental Biology.

Dr. Wellington Cardoso, Director for the Center for Human Development at Columbia University Medical Center, comments: "I have been closely following the work of Dr. Coles and his mentor Dr. Kate Ackerman, since we share a similar research interest. Dr. Coles has made important contributions to our understanding of the mechanisms regulating diaphragm and lung morphogenesis… I am confident that he will continue to make great contributions to the field in his future career."

This outlook is also shared by Dr. Hartmut Land, Chair of the Department for Biomedical Genetics and Director of Research at the Wilmot Cancer Center: "Garry is an incredibly driven and inquisitive scientist, and he has a fabulous enthusiasm for his work…(He) has grown tremendously during his time in graduate school. His maturity and independence are ahead of the curve for most post-doctoral fellows." Dr. Land concludes, "Given (Garry's) exceptional talent to make things work, his curiosity and great persistence, I am certain that he will contribute significantly to any scientific environment... (and)… become a leader in his field".

Class of 2014 Prelim season begins

Thursday, May 12, 2016

On Friday, May 6th, Andrew Albee opened the 2016 season of Prelim Exams. According to his committee, Andrew passed his qualifying exam with flying colors, and the committee looks forward to the outcome of his work. His studies on the function of Lmx Homeobox transcription factors in early somatic progenitors of the Drosophila ovary are also the basis of an F31 application submitted in February of this year. Congratulations, Andrew!

28th Annual Genetics Day Meeting

Wednesday, May 11, 2016

Michael Levine

Dr. Michael Levine

This year's Genetics Day provided another opportunity to celebrate the impact of Genetics on science and medicine. An excellent selection of speakers from the University of Rochester Medical Center highlighted the importance of diverse genetic mechanisms ranging from chromatin remodeling in erythropoesis (Laurie Steiner) and DNA damage repair (Xi Bin) to translational control by riboswitches (Joe Wedekind) and di-codon usage (Elizbeth Grayhack). Genetics Day concluded with the Fred Sherman lecture by Dr. Michael Levine (Princeton University). His presentation on visualizing the mechanisms of transcriptional enhancers was equally entertaining and insightful. Originally from the Hollywood area, and by his own admission a closet movie producer, Dr. Levine wowed audiences with in vivo movies of enhancer reporters, shedding new light on what we all thought was an established principle of molecular genetics.

Grad student

  • Manisha Taya – Hammes Lab
    The Role of Estrogen Signaling in a Mouse Model for Lymphangioleiomyomatosis (Lam)
  • Sam Carrell – Thornton Lab
    Silencing of Myotonic Dystrophy Protein Kinase (Dmpk) Does Not Affect Cardiac or Muscle Function In Mice 

Post Docs

  • Walter Knight – Yan Lab
    The Role and Mechanism of Cyclic Nucleotide Phosphodiesterase 1c in Regulating Pathological Cardiac Remodeling and Dysfunction
  • Vincent Martinson - Jaenike lab
    Gut Microbiota of Distantly Related Drosophila Species Share Similar Bacterial Diversity

Genetics Day has been a long standing tradition at the University of Rochester And more recently includes the Fred Sherman lecture in memory of Fred Sherman a renowned biochemist and geneticist, who led international efforts to establish the yeast Saccharomyces cerevisiae as the premier genetic eukaryotic model system.  The lecture is made possible by a generous fund endowed by Fred Sherman's wife, Elena Rustchenko-Bulgac, herself a research professor at the URMC.  

When the Physical World is Unreliable: Study Finds Visual and Tactile Processing Deficits in Schizophrenia

Tuesday, May 10, 2016

Schizophrenia

A new study out today in the journal Translational Psychiatry sheds further light on the idea that schizophrenia is a sensory disorder and that individuals with the condition are impaired in their ability to process stimuli from the outside world. The findings may also point to a new way to identify the disease at an early stage and before symptoms become acute.

Because one of the hallmarks of the disease is auditory hallucinations, such as hearing voices, researchers have long suspected a link between auditory processing and schizophrenia. The new study provides evidence that the filtering of incoming visual information, and also of simple touch inputs, is also severely compromised in individuals with the condition.

“When we think about schizophrenia, the first things that come to mind are the paranoia, the delusions, the disorganized thinking,” said John Foxe, Ph.D., the chair of the University of Rochester Medical Center Department of Neuroscience and senior author of the study. “But there is increasing evidence that there is something fundamentally wrong with the way these patients hear, the way they feel things through their sense of touch, and in the way in which they see the environment.”

Read More: When the Physical World is Unreliable: Study Finds Visual and Tactile Processing Deficits in Schizophrenia

Denise Skrombolas Receives Award

Thursday, May 5, 2016

Dr. Denise Skrombolas was awarded the Rochester Vaccine Fellowship created by a donation from Dr. Michael Pichichero in honor of Dr. Porter Anderson one of the pioneers in the Hib vaccine.

Jennifer Judge Wins the University of Rochester’s Three Minute Thesis (3MT) Competition

Wednesday, May 4, 2016

Jennifer Judge at the 3MT competition

Jennifer Judge presenting at the 3MT competition

Jennifer Judge, a Toxicology graduate student in the Sime Lab, has won the Judge's Vote and People's Choice Award at the University of Rochester’s Three Minute Thesis (3MT) competition. The event was held today in the Class of ’62 auditorium, as 8 finalists delivered their research in only three minutes.

The judges will picked a winner ($1,000 in travel funds), then the students voted for whom they thought should receive the People’s Choice award ($500 in travel funds!). Congrats to Jennifer for winning both!

SA Government names Professors of the Year

Monday, May 2, 2016

Laurel Carney

Join us in congratulating Laurel for being selected as one of 4 Professors of the year from a extraordinary field of 63 candidates.

Laurel Carney, professor of biomedical engineering, won in the Engineering field. Her research focuses on the complex network of auditory nerve fibers that transmit the inner ear’s electrical signals to the brain with the goal of better hearing aids.

Carney earned her M.S. and Ph.D degrees in electrical engineering at the University of Wisconsin-Madison. She was an associate professor of biomedical engineering at Boston University and professor of biomedical engineering at Syracuse University before joining the Rochester faulty in 2007. She serves as professor in three departments – biomedical engineering, neurobiology and anatomy, and electrical and computer engineering.

Read More: SA Government names Professors of the Year

Elissa Wong Awarded Individual Pre-doctoral Fellowship from NIAAA

Sunday, May 1, 2016

Photo of Elissa Wong

Elissa Wong, a 4th year Toxicology Graduate Program student in Dr. Ania Majewska's lab received a perfect 10 review score and was awarded an NIH (NRSA) Individual Pre-doctoral Fellowship from the NIAAA. The title of her project is: Synaptic plasticity and microglial-synapse interactions after developmental alcohol exposure (2016-2018).
Congrats Elissa!

NGP Graduate Alum, Grayson Sipe, Wins Doty Thesis Award

Friday, April 29, 2016

Photo of Grayson Sipe

Grayson Sipe, recent doctoral graduate from the Majewska lab, received the Robert Doty prize for the 2016 outstanding dissertation in neuroscience. The Doty prize is named in the honor of longtime faculty member Robert Doty, who made great contributions to neuroscience research at the University of Rochester and nationally. It is awarded on the basis of the impact and importance of research, novelty of experimental design, independence and creativity of the student and research implications and relevance for neuroscience. Grayson’s thesis entitled “The Role of P2Y12 in non-pathological microglial functions during synaptic plasticity”, which he successfully defended on February 19th, 2016, embodied all these characteristics. Grayson has now moved to his postdoctoral position with Dr. Mriganka Sur at MIT. Dr. Peter Shrager presented Grayson the prize at the annual neuroscience retreat on Friday, April 29th.

Congratulations Grayson!!!

Subtle Chemical Changes in Brain Can Alter Sleep-Wake Cycle

Friday, April 29, 2016

Sleepy Brain

A study out today in the journal Science sheds new light on the biological mechanisms that control the sleep-wake cycle. Specifically, it shows that a simple shift in the balance of chemicals found in the fluid that bathes and surrounds brain cells can alter the state of consciousness of animals.

The study, which focuses on a collection of ions that reside in the cerebral spinal fluid (CSF), found that not only do these changes play a key role in stimulating or dampening the activity of nerve cells, but they also appear to alter cell volume causing brain cells to shrink while we sleep, a process that facilitates the removal of waste.

“Understanding what drives arousal is essential to deciphering consciousness and the lack thereof during sleep,” said Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study. “We found that the transition from wakefulness to sleep is accompanied by a marked and sustained change in the concentration of key extracellular ions and the volume of the extracellular space.”

The current scientific consensus is that the brain is “woken up” by a set of neurotransmitters – which include compounds such as acetylcholine, hypocretin, histamine, serotonin, noradrenaline, and dopamine – that originate from structures deep within the brain and the brain stem. This cocktail of chemical messengers serve to activate – or arouse – a set of neurons in the cerebral cortex and other parts of the brain responsible for memory, thinking, and learning, placing the brain in a state of wakefulness.

Read More: Subtle Chemical Changes in Brain Can Alter Sleep-Wake Cycle

Heather Natola Wins 2016 Edward Peck Curtis Award for Excellence in Undergraduate Teaching

Thursday, April 28, 2016

Heather NatolaWe are proud to announce that Heather Natola has been selected to receive the 2016 Edward Peck Curtis Awards for Excellence in Undergraduate Teaching. Ms. Natola received high praise from her students, faculty in the Department of Biomedical Genetics and Rochester Museum and Science Center.

Ms. Natola is a graduate student researcher in the Pröschel Lab, where she investigates new therapeutic approaches to spinal cord injury as part of the UR Stem Cell and Regenerative Medicine Institute.

Heather Presented with award "Ms. Natola was particularly instrumental in providing students with in-depth and detailed training, which had a significant positive impact on the student’s engagement and learning"
-Hartmut Land, Ph.D., Chair, Department of Biomedical Genetics

"Despite her ambitious and demanding research work, Heather has volunteered for all of these teaching activities. Clearly she has not only become an ambassador for science as a whole, but has helped fulfill the mission of our school. What more can we ask of a graduate student?"
Christoph Proschel, Ph.D., Program Director - Genetics Development & Stem Cells Ph.D. Program 

Heather is enthusiastic and committed to promoting interest in science and an attitude of life-long learning
-Kara Verno, Program Supervisor - Rochester Museum and Science Center

Community Talk on Zika Virus Features Infectious Disease Expert from Brazil

Tuesday, April 19, 2016

As the warm summer season approaches, the possibility of a Zika outbreak in the United States looms large. The greatest concern is for women of childbearing age, as studies continue to link exposure to the virus in pregnancy to serious birth defects like microcephaly, hearing loss and blindness.

Esper Kallas, M.D., Ph.D., an infectious diseases specialist and professor of Medicine at the University of Sao Paulo, Brazil will speak about Zika virus on Monday, May 9 at 7:30 pm in the Eisenhart Auditorium at the Rochester Museum and Science Center. The event is free and open to the public. Kallas will be joined by a panel of experts from the University of Rochester Medical Center:

Read More: Community Talk on Zika Virus Features Infectious Disease Expert from Brazil

Congratulations to NGP student Aleta Steevens

Friday, April 8, 2016

Photo of Aleta Steevens

Aleta Stevens, an NGP student in Dr. Amy Kiernan's lab, secured a 3-year NIH Individual Pre-doctoral Fellowship, F31 entitled, "Elucidating the role of SOX2 in inner ear development."

Excellent work Aleta!

Harold Smith Inducted into Royal Society of Biology

Friday, April 8, 2016

Dr. Harold Smith, Professor of Biochemistry & Biophysics has been inducted into the Royal Society of Biology.

A long time member of the department, Dr. Smith's primary interest is understanding the composition, regulation and structure of macromolecular complexes involved in regulating gene expression at the level of messenger RNA expression and processing. The lab's focus is on a platform of enzymes that change the genetic code at the DNA or RNA level by deaminating cytidine to form uridine. Current data suggest that this family of cytidine deaminase function with other proteins (auxiliary proteins) as holoenzymes complexes which we refer to as editosomes (for RNA) or mutasomes (for DNA). RNA editing or DNA mutational activity by these enzymes affect the protein coding capacity of mRNAs and thereby can diversify the proteins that are expressed by cells (the proteome). Please visit the Smith Lab for more information. Dr. Smith has a 30 year track record of teaching and mentoring graduate students, medical students and undergraduates at the University of Rochester and has lead curriculum design and reform for these programs.

The Royal Society of Biology (RSB), previously called the Society of Biology, is a learned society in the United Kingdom created to advance the interests of biology in academia, industry, education, and research. Formed in 2009 by the merger of the Biosciences Federation and the Institute of Biology, the society has around 16,000 individual members, and over 100 member organizations. In addition to engaging the public on matters related to the life sciences, the society seeks to develop the profession and to guide the development of related policies.

Neuroscience Graduate Students Win Award for Teaching

Friday, April 8, 2016

Aleta Steevens

Neuroscience Graduate Program students, Aleta Steevens (Dr. Amy Kiernan lab) and Heather Natola (Dr. Chris Pröschel lab)  were awarded the 2016 Edward Peck Curtis Award for Excellence for Graduate Student Teaching.

Only a handful of these are awarded each year, and all this year's nominees were extremely well-qualified.

Congratulations to both!!!

Christina Cloninger Defends Thesis

Thursday, April 7, 2016

Photo of Christina CloningerCongratulations Dr. Cloninger on successfully defending your thesis!!

“Honeycomb” of Nanotubes Could Boost Genetic Engineering

Wednesday, April 6, 2016

Electron microscopic image of animal cells on array of nanotubes

Electron microscope image of animal cells (colored blue) cultured on an array of carbon nanotubes

Researchers have developed a new and highly efficient method for gene transfer. The technique, which involves culturing and transfecting cells with genetic material on an array of carbon nanotubes, appears to overcome the limitations of other gene editing technologies.

The device, which is described in a study published today in the journal Small, is the product of a collaboration between researchers at the University of Rochester Medical Center (URMC) and the Rochester Institute of Technology (RIT).

“This platform holds the potential to make the gene transfer process more robust and decrease toxic effects, while increasing amount and diversity of genetic cargo we can deliver into cells,” said Ian Dickerson, Ph.D., an associate professor in the Department of Neuroscience at the URMC and co-author of the paper.

Read More: “Honeycomb” of Nanotubes Could Boost Genetic Engineering

Study: The Science behind Bodily Secretions

Tuesday, April 5, 2016

The salivary gland secretes saliva that helps us chew and swallow the food we eat. The pancreas secretes digestive juices that enable our bodies to break down the fat, protein, and carbohydrates in the food. Secretions like these are important in countless activities that keep our bodies running day and night. A study published today in the journal Science Signaling uncovers a previously mysterious process that makes these secretions possible.

At the heart of the new study is calcium, which is present in all of our cells and is a gatekeeper of sorts: an increase in calcium in our cells opens up “gates” or “channels” that are required for the production and secretion of fluids like saliva. If calcium doesn’t increase inside cells the gates won’t open, a problem that occurs in diseases like Sjögren’s syndrome. Sjögren’s patients experience dry mouth due to a lack of saliva and have difficulty chewing, swallowing, and speaking, which severely hampers quality of life.

For the past 15 years David I. Yule, Ph.D., professor in the department of Pharmacology and Physiology at the University of Rochester School of Medicine and Dentistry has studied calcium’s role in Sjögren’s and other disorders in which calcium and secretions are disrupted, like acute pancreatitis. In the new study he answers an important question that has stumped scientists for years: what does it take for a particularly important calcium channel to open and start these processes?

Read More: Study: The Science behind Bodily Secretions

Professor Harold Smith to Organize Meeting on Drug Discovery

Thursday, March 31, 2016

The Clinical Science and Drug Discovery Conference had its inaugural meeting in 2015 in Baltimore, MD where Dr. Smith was asked to serve as a Keynote Speaker (and judge for poster sessions). The organizers of that meeting nominated him to organize this years meeting in Dundee, Scotland along with Drs. Ian Catchpole from GlaxoSmithKline in the UK and Nikolai Zhelev, professor at Abertay University, the hosting institution. The meeting will be held July 27-29. Dr. Smith will also deliver a keynote lecture at this meeting and chair a special topics session that he is bringing together on 'Host Cell Factors as Therapeutic Targets'. For more information, please visit the Drug Discovery Summit site, see also the CSDD Brochure.

Q&A: Biologist earns raves for work with yeast

Wednesday, March 23, 2016

David Goldfarb, professor of biology and biochemistry, researches yeast as a model organism for understanding the aging process in humans. Goldfarb joined the Rochester faculty in 1988, five years after earning his PhD in biochemistry at the University of California, Davis, and completing postdoctoral work at Stanford University.

Goldfarb holds four patents and has been recognized with more than a dozen honors, including the Johnson & Johnson “Focused Giving Program” Award, the National Society of Collegiate Scholars Distinguished Member Award, and the March of Dimes Health Leadership Award in Education.

Read More: Q&A: Biologist earns raves for work with yeast

Early Wiring of Brain's “Fear” Centers Could Produce Long-term Consequences

Monday, March 21, 2016

Fear from Early Brain Wiring

New research shows that our brains may be hardwired to become sensitive to stressful environments at an early age and, if overstimulated, this may contribute to anxiety disorders and even psychotic syndromes later in life.

The study, which appears in the journal Brain Structure and Function, focuses on two structures deep in the brain. The central nucleus of the amygdala (Ce) is thought to be involved in responses to immediate threats and stimulus, such as becoming startled or freezing in reaction to a loud noise. The bed nucleus of the stria terminalis (BST) is thought to be involved in regulating a person’s state of vigilance, such as determining whether or not an environment or a situation poses a potential threat. Animal and human studies show that when the BST is activated by a threatening situation, we tend to slow down, become quieter, and stress hormones spike.

While Ce and BST reside in different parts of the brain, the two areas are hardwired to each other by axonal tracts – basically, bundles of long distance axon fibers that enable the separate regions to communicate with each other. However, until now it has not been clear when these connections form or the way in which they interact with each other.

In the study published today, a team of researchers led by Julie Fudge, M.D., with the Department of Neuroscience observed that these connections are made at a very early stage of development in non-human primates. They also found that the direction of the connection is essentially a one way street. The Ce – or immediate fear signaling center – conveys information to the BST, the structure that mediates general threat sensing or anxiety states. This arrangement suggests that repeated activation of the Ce by immediately fearful or traumatic events may shape long-term anxiety states in the BST.

Read More: Early Wiring of Brain's “Fear” Centers Could Produce Long-term Consequences

Omega 3 Fatty Acids May Reduce Bacterial Lung Infections Associated with COPD

Tuesday, March 15, 2016

Compounds derived from omega-3 fatty acids – like those found in salmon – might be the key to helping the body combat lung infections, according to researchers at the University of Rochester School of Medicine and Dentistry.

The omega-3 derivatives were effective at clearing a type of bacteria called Nontypeable Haemophilus influenzae (NTHi), which often plagues people with inflammatory diseases like chronic obstructive pulmonary disease (COPD).

COPD, which is most often caused by years of smoking, is characterized by inflammation and excessive mucus in the lungs that blocks airflow. Quitting can slow the progress of COPD, but it doesn’t halt the disease. Anti-inflammatory drugs are the most common treatment, however they suppress the immune system, which can put people with COPD at risk for secondary infections, most commonly NTHi bacterial infections.

“Our biggest concern with patients who have COPD is bacterial infections, which often put their lives at risk,” says Richard Phipps, Ph.D. professor of Environmental Medicine and director of the URSMD Lung Biology and Disease Program. “If we can figure out how to predict who is likely to get an infection, physicians could put them on a preventative medication.”

In his recent study, which was featured in the top ten percent of the March 15 issue of The Journal of Immunology, Phipps and lead author, Amanda Croasdell, a graduate student in the Toxicology program, tested the effectiveness of an inhalable omega-3 derivative to prevent NTHi lung infections in mice.

Read More: Omega 3 Fatty Acids May Reduce Bacterial Lung Infections Associated with COPD

The Brain’s Gardeners: Immune Cells ‘Prune’ Connections Between Neurons

Monday, March 7, 2016

MicrogliaMicroglia (green) with purple representing the P2Y12 receptor which the study shows is a critical regulator in the process of pruning connections between nerve cells.

A new study out today in the journal Nature Communications shows that cells normally associated with protecting the brain from infection and injury also play an important role in rewiring the connections between nerve cells. While this discovery sheds new light on the mechanics of neuroplasticity, it could also help explain diseases like autism spectrum disorders, schizophrenia, and dementia, which may arise when this process breaks down and connections between brain cells are not formed or removed correctly.

“We have long considered the reorganization of the brain’s network of connections as solely the domain of neurons,” said Ania Majewska, Ph.D., an associate professor in the Department of Neuroscience at the University of Rochester Medical Center (URMC) and senior author of the study. “These findings show that a precisely choreographed interaction between multiple cells types is necessary to carry out the formation and destruction of connections that allow proper signaling in the brain.”

The study is another example of a dramatic shift in scientists’ understanding of the role that the immune system, specifically cells called microglia, plays in maintaining brain function. Microglia have been long understood to be the sentinels of the central nervous system, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up dead cell tissue. However, scientists are now beginning to appreciate that, in addition to serving as the brain’s first line of defense, these cells also have a nurturing side, particularly as it relates to the connections between neurons.

Read More: The Brain’s Gardeners: Immune Cells ‘Prune’ Connections Between Neurons

The Future of Photonics

Tuesday, February 23, 2016

As hundreds of millions of dollar pour into Rochester to establish the nation's first Photonics Hub, Mark Gruba has a closer look at the technology in a News 8 special report, "The Future of Photonics."

Photonics is the science and technology of generating, controlling and detecting photons, which are particles of light. A display at the Rochester Museum & Science Center houses examples of its many applications. In one, a transmitter converts an audio signal from electrical pulses into light pulses. The laser beam sends that information to the receiver, which converts the light pulses back to electrical pulses and sends them to the speaker for your listening enjoyment.

"We work on optical bio sensors," said Dr. Ben Miller, a researcher at the University of Rochester Medical Center. He's creating a sensor that can detect the presence of hundreds of viruses from a single blood sample, in real time. "We're working to make devices so that you can immediately get that information in the doctor's office," said Dr. Miller.

Read More: The Future of Photonics

Hope, Hype, and Wishful Thinking

Monday, February 22, 2016

Dr. Goldman

In a perspective piece appearing in the journal Cell Stem Cell, URMC neurologist Steve Goldman, M.D., Ph.D., lays out the current state of affairs with respect to stem cell medicine and how close we are to new therapies for neurological disorders.

The dawn of stem cell medicine some 25 years ago was greeted with great enthusiasm, particularly by scientists who study diseases in the central nervous system (CNS).  Many of the diseases found in the brain and spinal cord are degenerative in nature; meaning that over time populations of cells are lost due to genetic factors, infection, or injury.  Because stem cell medicine holds the potential to repair or replace damaged or destroyed cells, scientists have considered these diseases as promising candidates for new therapies.

However, as with other emerging fields of medicine, the race to cures has turned out to be more of marathon than a sprint.  While scientists have become very adept at manipulating stem and progenitor cells and understanding the complex choreography of genetic and chemical signals that instruct these cells to divide, differentiate, and proliferate, researchers are still grappling with the challenges of how to integrate new cells into the complex network of connections that comprise the human brain.

Goldman, co-director of the URMC Center for Translational Neuromedicine, takes a sweeping view of where we stand and which CNS diseases may or may not ultimately benefit from future stem cell-based therapies.

Read More: Hope, Hype, and Wishful Thinking

Congratulations Dr. Sipe!

Wednesday, February 17, 2016

Make sure you congratulate Grayson Sipe on defending his thesis.
Way to go Grayson!

Richard Aslin's Rochester Baby Lab Shows

Wednesday, February 17, 2016

Amelia Smith sits on the floor of a newly remodeled wing of the University of Rochester's department of Brain and Cognitive Sciences. The 8-month old wears a headband of cottony roses, and tiny bubbles form in the corner of her mouth. She's completely entranced by the commotion around her.

Though few adults in the room can resist oohing and aww-ing, little Amelia is not there to be fawned over. She's there to work. Researchers at the UR's Baby Lab want to know what she's thinking, what she's learned so far in her young life, and how she learned it.

But there's a problem: Amelia can't talk yet.

The work being investigated in Richard Aslin's Baby Lab was written up in the City Newspaper article "Signs of Intelligent Life".

Read More: Richard Aslin's Rochester Baby Lab Shows

Tracking Melanoma Metastasis Leads to Key Gene Discovery

Wednesday, February 17, 2016

A Wilmot Cancer Institute investigator discovered a gene that’s required for the initiation of melanoma and the growth of disseminated melanoma cancer cells in the lungs.doctor using magnifier to look at mole

The findings suggest that the gene’s signaling pathway may be proof that melanoma stem cells exist, a question that’s being debated by scientists.

Lei Xu, Ph.D., associate professor of Biomedical Genetics at the University of Rochester Medical Center, is lead author of the study, which was recently published in PLOS ONE and funded by a Wilmot Cancer Institute pilot grant. The Xu lab investigates the multiple, complex steps that occur as cancer cells spread from the original tumor to other parts of the body.

Read More: Tracking Melanoma Metastasis Leads to Key Gene Discovery

Report Recommends More Treatment, Research, for Gulf War Vets

Monday, February 15, 2016

The cause of Gulf War illness is still a mystery but focusing on treatments and interventions might help the veterans of Operation Desert Storm as well as the troops of the future, according to an Institute of Medicine committee report led by University of Rochester Medical Center Professor Deborah Cory-Slechta.

In 1990 and ’91 nearly 700,000 U.S. troops deployed to the Persian Gulf region for a short, intense war. Few injuries or deaths occurred, but troops were exposed to chemical and biological weapons, vaccines, oil-fires, air pollution, bomb blasts, pesticides, extreme desert temperatures, and constant false alarms and fear of nerve-gas attacks.

After the war ended a high number of the veterans reported debilitating fatigue, muscle and joint pain, headaches, and cognitive problems. This became known as “Gulf War illness.” During the past 25 years, 10 different committees of the nation’s top medical experts have searched for evidence that would better define Gulf War illness and possible treatments. The latest committee, headed by Cory-Slechta, concluded that no single mechanism can explain the multitude of symptoms seen in Gulf War illness—and that it’s unlikely a cause will ever be identified.

Read More: Report Recommends More Treatment, Research, for Gulf War Vets

Doing something larger than you could ever do on your own

Friday, February 12, 2016

"There is a tendency for many investigators, especially early in their careers, to hold onto their work and not share it," says David Williams, the William G. Allyn Professor of Medical Optics; Dean for Research in Arts, Sciences and Engineering; Director of the Center for Visual Science - and a leading eye expert who pioneered the use of adaptive optics for vision correction.

"They don't realize - and it's one of the things that took me longer to learn than I wish it had - that one of the best ways to build your reputation is to share your ideas or your technology with the hope that they will be adopted.

"I was lucky enough to realize that if I let my students take my adaptive optics technology and use it to build their own labs, for example, it not only helped them get their independent research programs off the mark but also enhanced my reputation because so many more people were able to access and deploy the technology."

Is it any wonder then, that of the five NEI Audacious Goals grants recently awarded to Williams and four other investigators:

  • four of the projects use adaptive optics as their core technology?
  • three of the other PI's are either current collaborators with Williams or former postdocs in his lab?
  • which means that four of the PI's will be cooperating with each other, even as they individually collaborate with other experts in the field on their individual projects - in effect widening the opportunities for synergy?

    "That's the excitement of this," Williams says. "Why should we compete when one group can do one piece of it, and a second group can do another, and as along as you can manage authorships and credit appropriately and fairly, we can be much more efficient and effective in getting things done?"

    "One of the things I'm proudest about in this community of people around the world doing adaptive optics and retinal imaging is that almost all of us get along really well, and we're moving science forward as rapidly as we can by helping each other. That doesn't always happen in science."

    As Dean of Research for Arts, Science and Engineering, Williams is always looking for young faculty throughout AS&E who have the right personality and vision to take on larger, multi-investigator, multi-institutional projects.

    "You have to be gregarious and interested in working with other people and tolerating the quirks that they have, just as they have to tolerate the quirks you have," Williams said.

    "The largest source of optimism for me about the AS&E research portfolio is the quality of our junior faculty members - their enthusiasm and energy. Many of them have cut their teeth on individual investigator awards and will reach a certain point in mid career when they realize they need to reach out for complementary expertise in order to do more."

    Williams' advice: The best collaborator may not be the first one that comes to mind.

    "One of the biggest mistakes faculty members make is to choose a collaborator who is just like them, who has the same interests in a problem and the same background and who they can easily begin a conversation with because they are so closely aligned. But that doesn't really help your research. You want to have somebody who . . . has a completely different skills set. As obvious as that is, it doesn't always get factored into planning how to accumulate the necessary wisdom to do something larger than you could ever do on your own."

Scientists Seek to Improve Flu Vaccine for the Very Young

Thursday, February 11, 2016

Scientists at the University of Rochester School of Medicine and Dentistry have discovered a way to make a nasal spray flu vaccine safer for those who are at greatest risk of catching the flu, particularly infants under the age of 2. The work is early and a long way from being applied in people, but offers promise for a vaccine that could better protect the most vulnerable.

Read More: Scientists Seek to Improve Flu Vaccine for the Very Young

Study Sheds Light on Source of Drug Addicts' Risk-Taking Behavior

Wednesday, February 10, 2016

Representation of Drug Addiction

A study out today provides new insight into how the brains of drug addicts may be wired differently. The findings, which appear in the journal Psychopharmacology, show that while drug users have very strong motivation to seek out "rewards," they exhibit an impaired ability to adjust their behavior and are less fulfilled once they have achieved what they desire. Addressing this disconnect between the craving for a drug and the ability to regulate behavior may be one of the keys to breaking the cycle of addiction.

"The vast majority of people, when faced with something they want, will assess how achievable the goal is and adjust their actions and expectations in order to maximize their potential to achieve it," said John Foxe, PhD, the chair of the Department of Neuroscience at the University of Rochester Medical Center and senior author of the study. "However, it appears that the integrity of this system of assessment and self-regulation is impaired in substance abusers and this may contribute to the risk-taking behaviors and poor decision-making commonly associated with this population."

Read More: Study Sheds Light on Source of Drug Addicts' Risk-Taking Behavior

Lead poisoning still an issue in Rochester

Tuesday, February 9, 2016

The Michigan city of Flint became ground zero of the nation's latest public-health outrage when it was learned in recent months that its tap water contained unsafe levels of toxic lead.

Though the aqueous cause of its lead problem is unusual, Flint is otherwise far from unique. Many American cities, including Rochester, continue to struggle with lead poisoning, particularly of children.

In fact, despite years of successful anti-lead work locally, the proportion of children in Rochester found to have elevated levels of lead in their blood still was roughly double that of their counterparts in Flint in 2014, the most recent year for which comparable data are available.

We have had a huge amount of progress here. We’ve had a nearly 90 percent reduction in the number of kids with elevated blood lead levels in the past 15 years, said Katrina Smith Korfmacher, an associate professor of environmental medicine at the University of Rochester Medical Center who has long been involved in local anti-lead efforts. But I would say it’s still a serious, or an ongoing, problem. The point is, it won’t ever go away entirely, because there is lead in the environment.

Read More: Lead poisoning still an issue in Rochester

Scientists Discover Stem Cells Capable of Repairing Skull, Face Bones

Monday, February 1, 2016

The photo shows a blue-stained stem cell and a red-stained stem cell that each generated new bones cells after transplantation.
The photo shows a blue-stained stem cell and a red-stained stem cell that each generated new bones cells after transplantation.

A team of Rochester scientists has, for the first time, identified and isolated a stem cell population capable of skull formation and craniofacial bone repair in mice—achieving an important step toward using stem cells for bone reconstruction of the face and head in the future, according to a new paper in Nature Communications.

Senior author Wei Hsu, Ph.D., dean’s professor of Biomedical Genetics and a scientist at the Eastman Institute for Oral Health at theUniversity of Rochester Medical Center, said the goal is to better understand and find stem-cell therapy for a condition known as craniosynostosis, a skull deformity in infants. Craniosynostosis often leads to developmental delays and life-threatening elevated pressure in the brain.

Hsu believes his findings contribute to an emerging field involving tissue engineering that uses stem cells and other materials to invent superior ways to replace damaged craniofacial bones in humans due to congenital disease, trauma, or cancer surgery.

For years Hsu’s lab, including the study’s lead author, Takamitsu Maruyama, Ph.D., focused on the function of the Axin2 gene and a mutation that causes craniosynostosis in mice. Because of a unique expression pattern of the Axin2 gene in the skull, the lab then began investigating the activity of Axin2-expressing cells and their role in bone formation, repair and regeneration. Their latest evidence shows that stem cells central to skull formation are contained within Axin2 cell populations, comprising about 1 percent—and that the lab tests used to uncover the skeletal stem cells might also be useful to find bone diseases caused by stem cell abnormalities.

The team also confirmed that this population of stem cells is unique to bones of the head, and that separate and distinct stem cells are responsible for formation of long bones in the legs and other parts of the body, for example.

The National Institutes of Health and NYSTEM funded the research.

Read More: Scientists Discover Stem Cells Capable of Repairing Skull, Face Bones

Strong Star Certificate of Appreciation Awarded to Dr. Jermaine “JJ" Jenkins

Tuesday, January 26, 2016

On January 22, 2016, Dr. Jermaine Jenkins, who runs the Structural Biology and Biophysics Facility, was nominated for going 'above and beyond' in his work for a client of the facility. The client commented in their nomination:

The clinical trials group had a very tight timeline to meet for one of our clients. Testing had to be completed by the 25th of January so the client could present the data to the FDA. JJ was aware of the required quick turnaround time and he met the challenge. He worked the weekend so that our client's needs would be met. It is so impressive to work with such a dedicated scientist who takes his job so seriously. With JJ's help, URMC Labs Clinical Trials group made a very good impression on a client.

As Facility Manager of the Structural Biology and Biophysics Facility, Dr. Jenkins offers support services to determine macromolecular x-ray crystal structures, and to investigate protein-protein, protein-nucleic acid or protein-small molecule interactions. Professor Clara Kielkopf – a long time user and co-founder of the Facility commented, JJ quickly, calmly and reliably responds to user needs. Co-director of the Facility Professor Joseph Wedekind added, Dr. Jenkins is an outstanding and dedicated scientist. We are fortunate to have such a great colleague. Please join us in expressing your gratitude to JJ for his service and dedication.

CTSI Trainee Pilot supports better understanding of lupus

Friday, January 15, 2016

Lupus is a devastating disease that affects around 1 in 2,000 people in the U.S., and involves chronic inflammation and tissue damage in various organs including the skin, kidneys, and joints. Although the mortality rate for lupus has improved in recent decades, a diagnosis of lupus often means elevated risk of early mortality and lifetime of immunosuppressive therapy, which can carry significant side effects.

Read More: CTSI Trainee Pilot supports better understanding of lupus

The Scientist as Storyteller

Friday, January 15, 2016

photo of graduate students at Rochester

Graduate students Clarence Ling (left), Jon Baker,
and Karl Smith rehearse a script for The Bootleggers
at the WRUR studios in Todd Union. (Photo: Adam Fenster)

For Karl Smith, the storytelling bug began with a Montgomery Ward No. 22 typewriter purchased for $5 at a moving sale.

Typewriter perched on his lap, the doctoral student in biophysics has become a fixture at the Rochester Public Market, Corn Hill Arts Festival, and other Rochester-area arts-oriented venues. For 10 cents, he crafts a half-sheet-long tale about grandchildren, lost loves, pets, or the absurd. The clacking of keys on paper draws a curious crowd.

I derive a lot of meaning and joy from making things that other people draw joy from, says Smith.

As a graduate student at Rochester, Smith has been finding lots of ways to share his love of storytelling. In addition to his peripatetic typewriting, he’s the leader of Rocket Radio Theater, a troupe of radio performers whose core membership includes fellow like-minded medical science graduate students Clarence Ling, Jon Baker, Carolyn Klocke, Bronwyn Lucas, and Matt Payea.

The project began in 2013 with a recording at Smith’s kitchen table. The group, which now records in the studios of campus radio station WRUR, hosts several serial drama podcasts and stand-alone stories created by Smith. Its feature series, The Bootleggers, takes place during prohibition-era Rochester, playing up aspects of local history and landscapes.

In his research as a biophysicist, Smith explores nanoporous silicon membranes in the lab of James McGrath, professor of biomedical engineering. Smith describes the membranes as coffee filters made of glass that are 10,000 times thinner than a human hair.

But he hopes to continue to combine storytelling and science after graduation, perhaps as a science journalist or a podcaster.

I want to live in a world, he says, where people are standing on street corners writing stories.

Read More: The Scientist as Storyteller

What Frogs Can Teach Us About Tumors

Wednesday, January 13, 2016

Researchers at the University of Rochester School of Medicine and Dentistry are using frogs as a model to study human diseases. These frogs, called South African clawed frogs or Xenopus laevis, may not resemble humans on the outside, but they are very similar on a genetic level.

Read More: What Frogs Can Teach Us About Tumors

Toxic Chemicals May Weaken Infants' Response to TB Vaccine

Friday, December 18, 2015

Exposure to toxic chemicals while in the womb or in early life may weaken a baby's immune system response to the tuberculosis (TB) vaccine, researchers say.

The study focused on two common toxins: PCBs, an industrial chemical; and DDT, used in pesticides. These so-called "persistent" pollutants are not easily broken down and remain a health threat years after being banned.

PCBs were banned in the United States in 1979. DDT is banned in the United States, but is still used in some countries to control malaria-carrying mosquitoes, the study authors, from the University of Rochester in New York, said in a university news release.

"There are thousands of pollutants similar to PCBs and DDT with unknown health implications," study leader Dr. Todd Jusko, assistant professor in the departments of environmental medicine and public health services, said in the news release. "Our work provides a foundation for how these types of chemicals affect the developing immune system in infants around the world."

Read More: Toxic Chemicals May Weaken Infants' Response to TB Vaccine

Exposure to chemicals lowers babies' TB vaccine response

Wednesday, December 9, 2015

Fetal exposure to two chemicals -- polychlorinated biphenyls, or PCBs, and DDE, a product of the breakdown of the insecticide DDT -- can dampen infants' immune response to the tuberculosis vaccine, according to a new study of mothers and children.

Both chemicals have been banned in many countries, including the United States, but are considered persistent pollutants, which pose health risks long after being introduced into the environment, can accumulate. The effects of such pollutants can pass between species through the food chain.

PCBs were used in manufacturing and consumer products in the United States until 1979, but most people have detectable PCB concentrations in their blood. DDT was banned in the United States in 1972, though many countries still use it to control the spread of malaria by mosquitoes.

There are thousands of pollutants similar to PCBs and DDT with unknown health implications, said Dr. Todd Jusko, an assistant professor at the University of Rochester, in a press release.

Read More: Exposure to chemicals lowers babies' TB vaccine response

B&B Professor Harold Smith and Oyagen's Drug Development Highlighted on Local TV for World Aids Day

Friday, December 4, 2015

OyaGen, a small medical research firm off Jefferson Road in Henrietta, has used federal grants for its HIV drug discovery programs with the goal of finding a cure. Dr. Harold Smith, Professor of Biochemistry & Biophysics at the University of Rochester, and the company's founder, president and CEO got his start as a molecular biologist studying heart disease.

"It became clear to me that the things we were doing to study heart disease and find out why things were happening translated directly into the HIV research arena," Smith said.

By 2010, things kicked into high gear. Advanced robotics were added allowing scientists to work with advanced chemistries. They've now identified a weak point in the HIV virus that's never been exploited before. Vif is a viral defense HIV releases into cells it infects. It destroys the body's natural defense against infections. OyaGen discovered a way to defeat HIV by disabling Vif.

"If we can proceed along track, we will be looking at entering clinical trials within a completely different way of approaching the virus and the disease within three years," Smith said.

To read more see the Channel 8 story.

Gloria Culver to Be Installed as Dean

Tuesday, December 1, 2015

Former Biochemistry graduate student and current Chair of Biology, Dr. Gloria Culver, will be formally installed as dean of the School of Arts & Sciences during an investiture ceremony at 4 p.m. today in the Interfaith Chapel on the River Campus.

University Trustee Ani Gabrellian ’84 will provide opening remarks, followed by words from Provost Peter Lennie, the Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences & Engineering. Mariette Westermann, vice president of the Andrew W. Mellon Foundation, and Jon Lorsch, director of the National Institute of General Medical Sciences, will serve as guest speakers. Following the ceremony, a reception will be held in the Hawkins-Carlson Room of Rush Rhees Library.

Read More: Gloria Culver to Be Installed as Dean

Study Provides New Insight on Stem Cell Function

Tuesday, December 1, 2015

Researchers in the Department of Biomedical Genetics have unraveled one of the key molecular mechanisms that regulate stem cell behavior, a discovery that could provide important insight into regenerative medicine and certain forms of cancer.

The study – led by Benoit Biteau, Ph.D. – appears in the journal Cell Reports, and was conducted in fruit flies, or drosophila.  While diminutive in stature, fruit flies have proven to be an invaluable research tool and have made oversized contributions to medicine, particularly in the fields of molecular biology and genetics.

Benoit and his colleagues focused on a transcription factor called Sox21a which is uniquely found in the stem cells of the drosophila intestine.  Transcription factors are proteins that control the expression of genes and, subsequently, help regulate cellular activity.  Sox21a is the equivalent of Sox2, a transcription factor found in humans that is known to play an important role in the function of stem cells and cell reprogramming.

Read More: Study Provides New Insight on Stem Cell Function

Anna Bird Receives Two Awards

Thursday, November 19, 2015

Anna Bird has received the Randy N. Rosier Award for public speaking ($1000 in travel funds received at the URMC CMSR Symposium 2015) and the American Association of Immunologists (AAI) Trainee Abstract Award ($750 in travel funds for AAI New Orleans Conference, 2015).

NASA Grant Will Explore Impact of Space Travel on the Brain

Friday, November 13, 2015

M. Kerry O'Banion Kerry O'Banion, M.D., Ph.D., has been awarded $1.8 million from NASA to study whether extended deep space travel places astronauts at risk for neuro-degenerative diseases like Alzheimer's.

The grant is one of nine announced by NASA that will fund research that employ beams of high-energy, heavy ions simulating space radiation. The studies will be conducted in part at the NASA Space Radiation Laboratory at Brookhaven National Laboratory on Long Island. By colliding matter together at very high speeds, the accelerators at Brookhaven can reproduce the radioactive particles found in space.

The studies will seek to better understand and reduce the risks to humans associated with long journeys in deep space, specifically focusing on neurological and cardiovascular diseases and cancer. Understanding the potential health impact of space travel is a priority for NASA as it develops future plans for maned voyages to Mars and other destinations.

Read More: NASA Grant Will Explore Impact of Space Travel on the Brain

UR Scientist Wins Novo Nordisk Award to Develop Obesity Drug

Wednesday, November 11, 2015

Dr. Phipps in Laboratory

University of Rochester Medical Center researcher Richard P. Phipps, Ph.D., won a top scientific award from the pharmaceutical giant Novo Nordisk, to collaborate on a new obesity therapy based on his laboratory’s discoveries.

Phipps, the Wright Family Research Professor of Environmental Medicine, is the first UR faculty to receive the competitive Novo Nordisk Diabetes and Obesity Biologics Science Forum Award. The drug company is providing substantial financial support for the two-year project, which is designed to quickly move basic science in diabetes and obesity to an early stage of drug development known as proof-of-principle.

Phipps discovered a new function for a protein known as Thy1 (formally called CD90), linking it to fat cell accumulation.

Read More: UR Scientist Wins Novo Nordisk Award to Develop Obesity Drug

Nguyen Mai Wins Poster Competition at 2015 APSA/Tri-Institutional MSTP Conference

Monday, November 9, 2015

Congratulations to Nguyen Mai for winning first place for the poster competition at the 2015 APSA/Tri-Institutional MSTP Conference at SUNY Upstate in Syracuse, NY.

Study: Brain's Immune System Could Be Harnessed to Fight Alzheimer's

Wednesday, November 4, 2015

M. Kerry O'BanionA new study appearing in the Journal of Neuroinflammation suggests that the brain’s immune system could potentially be harnessed to help clear the amyloid plaques that are a hallmark of Alzheimer’s disease.

This research confirms earlier observations that, when activated to fight inflammation, the brain's immune system plays a role in the removal of amyloid beta, said M. Kerry O'Banion, M.D., Ph.D., a professor in the University of Rochester Department of Neurobiology and Anatomy, the Del Monte Neuromedicine Institute, and the lead author of the study. We have also demonstrated that the immune system can be manipulated in a manner that accelerates this process, potentially pointing to a new therapeutic approach to Alzheimer's disease.

The findings are the culmination of years of investigation that were triggered when O'Banion and his colleagues made a surprising discovery while studying mouse models of Alzheimer's disease. They observed that amyloid beta plaques – which scientists believe play a major role in the disease – were being cleared in animals with chronic brain inflammation.

For more information, visit the URMC Newsroom

Read More: Study: Brain's Immune System Could Be Harnessed to Fight Alzheimer's

Congratulation Fatima Rivera-Escalera

Monday, November 2, 2015

Fatima Rivera-EscaleraFatima has successfully defended her PhD thesis.

Congratulations Dr. Rivera-Escalera!!!

Congratulations to Monique Mendes, 1st year NGP student!

Friday, October 30, 2015

Monique MendesMonique was recognized at the 2014 Annual Biomedical Research Conference for Minority Students (ABRCMS) for an outstanding poster/ oral presentation and was awarded an AHA/ASA Travel Award. This award is given to recognize promising and outstanding investigators in the early stages of their careers, and provide travel assistance to participate in the upcoming 2015 Scientific Sessions. Scientific Sessions is the American Heart Association's largest gathering of scientists and healthcare professionals devoted to the science of cardiovascular disease and stroke and the care of patients suffering from these diseases. It is the leading cardiovascular meeting in the country with over 17,000 professionals attending annually, and over 22,000 total attendees. Programming for this meeting is designed to improve patient care by communicating the most timely and significant advances in prevention, diagnosis and treatment of cardiovascular disease from many different perspectives. Sessions provides five days of comprehensive, unparalleled education through more than 4,000 presentations given by some of the world's top leaders in the areas of cardiovascular disease, as well as a chance to experience more than 300 exhibitors showcasing the latest cardiovascular technology and resources.

This year's Scientific Sessions will be held November 7th - 11th in Orlando, FL

What We Hear, Even Subconsciously, Fine Tunes Our Sense of Distance

Friday, October 30, 2015

Duje TadinMost of us at one time or another have counted the seconds between a lightning flash and its thunder to estimate distance. University researcher Duje Tadin and his colleagues have discovered that humans can unconsciously notice and make use of sound delays as short as 40 milliseconds (ms) to fine tune what our eyes see when estimating distances to nearby events.

Much of the world around us is audiovisual, says Tadin, Associate Professor of Brain and Cognitive Sciences and senior author of the study. Although humans are primarily visual creatures, our research shows that estimating relative distance is more precise when visual cues are supported with corresponding auditory signals. Our brains recognize those signals even when they are separated from visual cues by a time that is too brief to consciously notice.

For the study, published in PLOS ONE, researchers used projected three-dimensional (3D) images to test the human brain's ability to use sound delays to estimate the relative distance of objects.

For the entire story, visit the Univ. Rochester Newscenter.

Read More: What We Hear, Even Subconsciously, Fine Tunes Our Sense of Distance

Lynne Maquat Receives Canada’s Top Prize for Biomedical Research

Thursday, October 29, 2015

Lynne Maquat recieves award

On October 29, Dr. Lynne E. Maquat received a 2015 Canada Gairdner International Award, for her work discovering and elucidating the mechanism of mRNA decay pathways. Dr. Maquat was accompanied during presentation of the award by University of Rochester President Joel Seligman, Dean Mark Taubman, and the US Ambassador to Canada, Bruce Heyman (see photo). The sold out annual black tie gala took place at the Royal Ontario Museum in Toronto, Canada and was attended by members of the health care, academic, private and public sectors (additional pictures here). Among the attendees were Nobel Laureate Dr. Phillip Sharp, His Excellency the Right Honourable David Johnston, Governor General of Canada, and the Swiss and Japanese Ambassadors to Canada, who accompanied recipients of the Canada Gairdner International Award from those countries.

Leading up to this event, Dr. Maquat visited four local universities where she spoke to high school students about her personal story of how she became interested in research and what she hopes to achieve through her work. She also met with post-docs and graduate students at each university as well as speaking to faculty members about their research. Following the gala, Dr. Maquat attended and spoke at a 2015 Gairdner Symposium RNA and The New Genetics at the University of Toronto, which she helped coordinate. Her last event occurred at the University of New Brunswick, Fredericton where she once again spoke to high school students On being a Scientist: Uncovering the mysteries of life and met with post-docs and graduate students about their research. Dr. Maquat took every opportunity to be part of the National Program, where the goal of these programs is to contribute to Canadian science culture and innovation, and to be part of the Student Outreach Programs where she helped realize one of the Gairdner Foundation’s missions to inspire young people to consider a career in science, and to increase their awareness of the value of scientific research.

Sigma Xi awards David R. Williams the William Procter Prize for Scientific Achievement

Monday, October 26, 2015

David R. Williams, widely regarded as one of the world’s leading experts on human vision, has been named the recipient of Sigma Xi’s 2015 William Procter Prize for Scientific Achievement. The prize is given annually since 1950 in recognition of outstanding achievement in scientific research and demonstrated ability to communicate the significance of this work to scientists in other disciplines. Past Procter Prize recipients have included Jane Goodall, Vannevar Bush, Margaret Mead, Murray Gell-Mann, and Rita Colwell.

He will be presented the Procter Prize at an evening ceremony on Saturday, Oct. 24 in Kansas City, during the scientific research society Sigma Xi’s annual meeting.

For the entire article, visit the Rochester NewsCenter.

Read More: Sigma Xi awards David R. Williams the William Procter Prize for Scientific Achievement

URMC using photon laser for cancer research

Saturday, October 24, 2015

Edward BrownEdward Brown's research is a mixture of photonics, microscopes and a little nudge from his mom.

Brown, who teaches biomedical engineering at the University of Rochester Medical Center, has built a laser-and-microscope device to study how likely cancer cells will spread throughout the body. Specifically, he's looking at how likely cancer cells have spread inside breast cancer patients who already have had the tumor removed.

Learning more about the cell movement, called metastasis, is key to a larger overtreatment problem that Brown is trying to fix.

When patients first realize they have breast cancer, it's unclear whether the cancer cells have spread, so doctors recommend chemotherapy as a precaution. However, Brown and other medical researchers believe patients are being overtreated because doctors are giving chemo to patients who may not need it.

Read More: URMC using photon laser for cancer research

Clerio Vision licenses ground-breaking approach to vision correction developed by Huxlin, Knox and Ellis

Friday, October 23, 2015

LASIK revolutionized vision correction in the 1990s. Now, a new technology arising from research conducted by Wayne Knox, Professor of Optics and Physics; Krystel Huxlin, Professor of Ophthalmology; and Jonathan Ellis, Assistant Professor of Mechanical Engineering, may do the same, notes UR Ventures Technology Review.

Known as LIRIC (Laser Induced Refractive Index Change), this ground-breaking method also uses a laser to correct the optical properties of the eye, but that's where the similarities to LASIK end.

The older technology uses two lasers and includes cutting the cornea to create a flap and then pulling that flap back to expose the inner cornea. A laser is then applied to ablate and reshape the corneal tissue to achieve the desired focus. The corneal flap is repositioned and the healing process begins. Complications are rare, but as with any surgery, are a concern. Fear of complications and of having one's eye cut are big reasons why less than 2 percent of people who are eligible for LASIK undergo the procedure.

The LIRIC method uses a laser at a much lower power and does not cut or remove any tissue. Instead, it is a non-invasive procedure that alters the refractive index of the corneal tissue to correct vision. Since the procedure doesn't thin the cornea like LASIK, it may be repeated many times over the course of a patient's lifetime as the eye grows and changes.

This technology has been licensed to Clerio Vision, Inc., a local startup poised to bring this new treatment to market. Clerio was started by a team of entrepreneurs with proven track records - Mikael Totterman (VirtualScopics, iCardiac), Alex Zapesochny (Lenel, iCardiac), Scott Catlin (AMO, Abbott Medical Optics - and now with UR Ventures), and Sasha Latypova (VirtualScopics, iCardiac). The company successfully concluded an oversubscribed Series A round of fundraising with participation from three venture capital firms, and is considering a Series B round to further accelerate product and clinical development. They have proven efficacy in animal models and hydro-gels (contact lenses), and plan to conduct human studies early in 2016.

Taylor Moon and Kyle Koster Receive Awards at Local Meetings

Thursday, October 22, 2015

Congratulations to Taylor Moon and Kyle Koster for their award-winning presentations at two local scientific meetings. Taylor received the "Excellence in Scientific Presentation" award at the Department of Microbiology and Immunology Retreat on October 6th 2015. Kyle received the second place award for his poster at the American Physician Scientists Association Northeast Regional Meeting in Syracuse October 17th 2015. Taylor and Kyle are Microbiology and Immunology doctoral students in the Elliott Lab in the Center for Vaccine Biology and Immunology.

Experimental Treatment Regimen Effective Against HIV

Monday, October 19, 2015

Protease inhibitors are a class of antiviral drugs that are commonly used to treat HIV, the virus that causes AIDS. Scientists at the University of Nebraska Medical Center designed a new delivery system for these drugs that, when coupled with a drug developed at the University of Rochester School of Medicine and Dentistry, rid immune cells of HIV and kept the virus in check for long periods. The results appear in the journal Nanomedicine: Nanotechnology, Biology and Medicine.

While current HIV treatments involve pills that are taken daily, the new regimens' long-lasting effects suggest that HIV treatment could be administered perhaps once or twice per year.

Nebraska researcher Howard E. Gendelman designed the investigational drug delivery system–a so–called nanoformulated protease inhibitor. The nanoformulation process takes a drug and makes it into a crystal, like an ice cube does to water. Next, the crystal drug is placed into a fat and protein coat, similar to what is done in making a coated ice–cream bar. The coating protects the drug from being degraded by the liver and removed by the kidney.

When tested together with URMC–099, a new drug discovered in the laboratory of UR scientist Harris A. (Handy) Gelbard M.D., Ph.D., the nanoformulated protease inhibitor completely eliminated measurable quantities of HIV. URMC–099 boosted the concentration of the nanoformulated drug in immune cells and slowed the rate at which it was eliminated, thereby prolonging its therapeutic effect.

Read More: Experimental Treatment Regimen Effective Against HIV

Ann Dozier Inducted into American Academy of Nursing

Thursday, October 1, 2015

October 2015.  Ann Dozer, Ph.D. was selected as one of 163 nurse leaders to be inducted as a fellow in the American Academy of Nursing for 2015. Academy fellows represent all 50 states, District of Columbia, and 24 countries and include government and hospital administrators, college deans, and renowned scientific researchers. 

Barbara Iglewski to Be Inducted into Women's Hall of Fame

Thursday, October 1, 2015

Barbara IglewskiBarbara Iglewski, professor emeritus in the Department of Microbiology and Immunology, will be inducted into the National Women's Hall of Fame this weekend. She is the third faculty member to be enshrined in Seneca Falls: Judith Pipher, professor emeritus of physics and astronomy, and Loretta Ford, founding dean of the School of Nursing, were inducted in 2007 and 2011, respectively.

Read More: Barbara Iglewski to Be Inducted into Women's Hall of Fame

Sneak Peak of The Brain with Dr. David Eagleman at The Little Theater Followed by Panel Discussion Featuring Liz Romanski

Monday, September 28, 2015

Lizabeth RomanskiThe Brain with Dr. David Eagleman
Wed, 09/30/2015 - 7:00pm - 9:00pm

Join WXXI for a special preview screening of a new series that tells the story of the inner workings of the brain.

The Brain with Dr. David Eagleman, a new six one-hour series that explores the human brain in an epic series that reveals the ultimate story of us, why we feel and think the things we do, premieres on WXXI-TV in October 14th. But before it does, you can enjoy a sneak preview of the series on the big screen at The Little Theater (240 East Avenue) on Wednesday, September 30 at 7 p.m. The event is free, but seats are first come first served. WXXI is pleased to partner with the Rochester Museum & Science Center to bring you this screening, followed by a panel discussion featuring Liz.

For further information, please visit the WXXI website.

Read More: Sneak Peak of The Brain with Dr. David Eagleman at The Little Theater Followed by Panel Discussion Featuring Liz Romanski

NSC Student Humberto Mestre M.D. Awarded Travel Grant to SFN 2015

Sunday, September 20, 2015

Photo of Humberto Mestre

Humberto Mestre, M.D.

In 2014, Humberto was selected for the Latin America Training Program by the Society for Neuroscience and the International Brain Research Organization.

This program was formerly known as the Ricardo Miledi Neuroscience Training Program. The Program allowed 15 young scientists from Latin America and the Caribbean to attend a three week course where top faculty from across the region and North America provided the young scientists with lectures, lab exercises using cutting edge techniques, and training on vital professional development topics - one speaker was Dr. Deborah Cory-Slechta.

The completion of the year-long participation culminated with a travel grant to attend the Society for Neuroscience Meeting 2015 in Chicago, IL and to present science at the International Fellows Poster Session to be held on Saturday, October 17 from 6:30 pm-8:30 pm in Hall A of McCormick Place.

Read More: NSC Student Humberto Mestre M.D. Awarded Travel Grant to SFN 2015

Wilmot Cancer Institute’s Research Director Wins $6.3M Outstanding Investigator Award

Thursday, September 17, 2015

Hartmut “Hucky” Land, Ph.D., the Robert and Dorothy Markin Professor of Biomedical Genetics at the University of Rochester, received a newly established multimillion dollar award from the National Cancer Institute that supports exceptional scientists with seven years of uninterrupted funding.

The NCI Outstanding Investigator Award (OIA) is in its inaugural year. It was designed to reward productive and influential researchers by giving them the freedom to pursue long-term goals without having to re-submit grants each cycle. He will continue to test a bold hypothesis that’s been the cornerstone of his work for 30 years—that different cancers have many shared features, and understanding the common characteristics of cancer might unlock the next generation of targeted treatments.

“I feel very grateful and a bit humbled,” said Land, director of research and co-director at UR Medicine’s Wilmot Cancer Institute. “It’s a wonderful affirmation of our focus on the common core of cancers and the work of our research team.”

Read More: Wilmot Cancer Institute’s Research Director Wins $6.3M Outstanding Investigator Award

NB&A Faculty take honors at Convocation 2015

Thursday, September 10, 2015

  • Ania Majewska PhD - Outstanding Graduate Program Director
  • John Olschowka PhD - 1st Year Teaching Special Commendation
  • Martha Gdowski PhD - Gold Medal Teaching Award
  • Nina Schor MD, PhD - Faculty Academic Mentoring Award

Congratulations All!!

2015 Awards Announced

Tuesday, September 8, 2015

MELVILLE A. HARE AWARD FOR EXCELLENCE IN GRADUATE RESEARCH (MBI): Denise Skrombolas and Benson Cheng

MELVILLE A. HARE AWARD FOR EXCELLENCE IN GRADUATE TEACHING (MBI): Jennifer Colquhoun

OUTSTANDING GRADUATE STUDENT TEACHER: Jim Miller, Ph.D.

EXCELLENCE IN POSTDOCTORAL MENTORING: Luis Martinez-Sobrido, Ph.D.

GRADUATE ALUMNI AWARD: Deborah Fowell, Ph.D.

OUTSTANDING T32 PROGRAM DIRECTOR: Stephen Dewhurst, Ph.D.

FIRST YEAR EXCELLENCE IN TEACHING: Constantine Haidaris, Ph.D.

FACULTY MENTORING AWARD FOR BASIC SCIENCE: Minsoo Kim, Ph.D.

SPECIAL COMMENDATION FOR FIRST YEAR TEACHING: John Frelinger, Ph.D.

OUTSTANDING POSTDOCTORAL MENTOR AWARD: Aitor Nogales Gonzalez, Ph.D.

OUTSTANDING POSTDOCTORAL RESEARCHER AWARD: Eva-Stina Edholm, Ph.D.

Immune Cells Take Cue from Animal Kingdom: Together, Everyone Achieves More

Friday, September 4, 2015

Much like birds fly in flocks to conserve energy, dolphins swim in pods to mate and find food, and colonies of ants create complex nests to protect their queens, immune cells engage in coordinated behavior to wipe out viruses like the flu. That’s according to a new study published in the journal Science by researchers at the University of Rochester School of Medicine and Dentistry.

The findings reveal, for the first time, how immune cells work together to get to their final destination – the site of an injury or infection. The body is expansive and a virus or bacteria can take hold in any number of locations: the lungs, the throat, the skin, the stomach or the ear, just to name a few. How do immune cells, specifically the ones that are responsible for killing foreign invaders, know where to go?

Read More: Immune Cells Take Cue from Animal Kingdom: Together, Everyone Achieves More

Alan Grossfield's Research Featured in Cosmos Article

Tuesday, September 1, 2015

Research performed by Associate Professor Alan Grossfield and colleagues into how a new class of drugs fights bacterial infections was highlighted in a recent Cosmos Magazine article. Dr. Grossfield's research was also recently highlighted in EurekaAlert!, an online magazine run by the American Association for the Advancement of Science.Read More: Alan Grossfield's Research Featured in Cosmos Article

EHSC Welcomes Dr. Martha Susiarjo

Tuesday, September 1, 2015

Susiarjo

The Environmental Health Sciences Center (EHSC) would like to welcome Dr. Martha Susiarjo to URMC.

Dr. Martha Susiarjo applies her background in epigenetics to understanding whether epigenetic regulation of genes contributes to gene-environment interaction during early development.  She joins us as Assistant Professor from the University of Pennsylvania, where she recently completed her postdoc studying environmental estrogens and regulation of imprinted genes (genes contributed by only one parent). Dr. Susiarjo employs a mouse model to understand the mechanism(s) by which environmental exposures – obesogenic endocrine disrupting chemicals in particular – during in utero development can shape the future health outcomes of the offspring.  She hopes to identify mechanisms in order to better inform exposure prevention efforts.

Dr. Susiarjo looks forward to collaborating with center members to utilize her expertise in epigenetics, especially DNA methylation, in various models of environmental perturbations.  She also hopes collaborative efforts can elucidate how nutritional intervention may provide protective effects on environment-induced developmental outcomes.

Carney lab looks beyond inner ear in quest for better hearing aids

Friday, August 28, 2015

Laurel CarneyMost hearing aids on the market today are designed to mimic what happens in our inner ear - specifically the amplifying role of the outer hair cells.

However, the lab of Laurel Carney, Professor of Biomedical Engineering, is studying what happens beyond the inner ear - in the complex network of auditory nerve fibers that transmit the inner ear's electrical signals to the brain, and in the auditory center of the midbrain, which processes those signals.

Therein lies the key to creating hearing aids that not only make human speech louder but clearer, Carney believes.

An important focus of her research uses a combination of physiological and behavioral studies, and computer modeling, to study the 30,000 auditory nerve fibers on each side of our brain that transmit electrical signals from the inner ear. Critical to this is the initial transduction of mechanical energy to electrical signals that occurs in the inner hair cells of the inner ear's organ of Corti.

This is critical for shaping the patterning of responses in the auditory nerves, and the patterning of those responses at this first level, where the signal comes into the brain, has a big effect on the way the mid brain responds to the relatively low frequencies of the human voice, Carney explained.

In people with healthy hearing, the initial transduction results in a wide contrast in how various auditory nerve fibers transmit this information. The responses of some fibers are dominated by a single tone, or harmonic, within the sound; others respond to fluctuations that are set up by the beating of multiple harmonics, Carney said. In the mid brain, neurons are capable of assimilating this contrast of fluctuating and nonfluctuating inputs across varying frequencies. They begin the process of parsing out the sounds of speech and any other vocalizations that involve low frequencies. A better understanding of how this process works in the midbrain, Carney believes, could yield new strategies for designing hearing aids.

A lot of people have tried to design hearing aids based just on what is going on in the inner ear, but there's a lot of redundancies in the information generated there. We argue that you need to step back and, from the viewpoint of the midbrain, focus on what really matters. It's the pattern of fluctuations in the auditory nerve fibers that the midbrain responds to. The sort of strategies we're suggesting are not intuitive. The idea of trying to restore the contrast in the fluctuations across different frequency channels has not been tried before. The burden is on us to prove that it works, she added.

To that end, Carney works closely with Joyce McDonough, Professor of Linguistics, in exploring how auditory nerve fiber transmissions play a role in coding speech sounds. Her lab also works closely with that of Jong-Hoon Nam, Assistant Professor of Mechanical Engineering and of Biomedical Engineering, whose inner-ear studies were described in this newsletter last week. Carney shares what her lab is learning about the interface of auditory nerve fiber signaling with the brain, and in return, we try to include in our models a lot of the nonlinear properties of the inner ear that he (Nam) has been working on. By interacting with his lab, we hope to continue to modernize our model as he discovers more, Carney said.

New patent issued for Professor Hocking

Wednesday, August 26, 2015

The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (US 9,072,706) has recently been assigned to the University of Rochester with inventors Denise C. Hocking, Ph.D. (Pharmacology and Physiology, BME, RCBU) and Daniel Roy, Ph.D. (BME PhD 2012 alumnus). The patent relates to a series of recombinant fibronectin peptide mimetics developed to promote wound repair. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Encouraging results from recent studies indicate that topical application of these fibronectin peptide mimetics to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization. Denise Hocking is an Associate Professor of Pharmacology and Physiology and of Biomedical Engineering. Daniel Roy is currently a post-doctoral fellow at the US Army Institute of Surgical Research in San Antonio, TX.

NGP students receive the 2015 Convocation Awards

Wednesday, August 26, 2015

Garrick Salois, 1st year student, is this year's recipient of the Irving L. Spar Fellowship Award.

Humberto Mestre, 1st year student, was awarded the Merritt and Marjorie Cleveland Fellowship.

Holly Beaulac, 1st year student, received this year's Graduate Alumni Fellowship Award.

Jenn Stripay, 5th year student, was selected to receive this year's Outstanding Student Mentor Award.

Congrats to all!

Eric Comeau Awarded AHA Fellowship

Saturday, August 15, 2015

Eric Comeau is the recipient of an American Heart Association Pre-Doctoral Fellowship. The fellowship will support Eric’s project titled “Ultrasound standing wave field technologies for cell patterning and microvessel network formation in vitro and in situ”. Through this project, Eric will advance new ultrasound technologies for tissue engineering applications. Eric is a graduate student in the Department of Biomedical Engineering and is co-mentored by Professor Diane Dalecki (BME) and Professor Denise C. Hocking (Pharmacology and Physiology; BME). Eric is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU).

Vision Expert David Williams Receives the Beckman-Argyros Award

Wednesday, August 12, 2015

photo of David Williams

David Williams, Ph.D.

$500,000 prize for his transformative breakthrough in vision research

David Williams, widely regarded as one of the world's leading experts on human vision, has been named the 2015 recipient of the Beckman-Argyros Award in Vision Research. Williams pioneered the use of adaptive optics technologies for vision applications. He serves as the William G. Allyn Professor of Medical Optics, director of the Center for Visual Science and dean for research in Arts, Science, and Engineering at the University of Rochester.

The award, bestowed by the Arnold and Mabel Beckman Foundation, rewards an individual who has made transformative breakthroughs in vision research. Williams will receive a total of $500,000, along with a solid gold commemorative medallion.

It's an incredible honor for me to receive this award from the Arnold and Mabel Beckman Foundation, said Williams. He added that one aspect that made this award particularly special is that it allows our group to take risks.

Read More: Vision Expert David Williams Receives the Beckman-Argyros Award

FDA Approves Tool for Diagnosing Dementia in a Doctor's Office

Monday, August 10, 2015

Charles Duffy, MD, PhD

Dr. Charles Duffy

A small company started by a neuroscientist at the University of Rochester has moved closer to providing doctors with what he says is a simple, computer-based tool to help detect early signs of Alzheimer's disease or other forms of dementia.

Cerebral Assessment Systems has received marketing approval from the U.S. Food and Drug Administration for Cognivue, a cognitive-assessment tool that functions somewhat like a video game. A patient can perform the inexpensive and simple test while a time-strapped primary-care physician tends to other patients. The 10-minute, non–invasive examination can detect subtle lapses in the brain’s perceptual ability that may signal the early stages of mental decline caused by dementia.

The federal government's approval to market the device comes as Alzheimer's researchers everywhere step up the pursuit for easier and more inexpensive ways to identify dementia in its earliest stages.

Look, there is a late-life tsunami of late-life cognitive decline coming at us, and health-care providers are standing on the beach, said Charles J. Duffy, a neurology professor at the University of Rochester Medical Center who founded the company. What we are all about is making cognitive care part of primary care.

Read the article from the Washington Post.

Read More: FDA Approves Tool for Diagnosing Dementia in a Doctor's Office

1st Annual Immune Imaging Symposium To Be Held November 7, 2015

Wednesday, August 5, 2015

The Program for Advanced Immune Bioimaging at the University of Rochester will host the 1st Annual Immune Imaging Symposium November 7th, 2015 from 8:30 am – 5pm.

The free symposium will provide a forum where the newest developments in understanding immune function through visualizing immunity ‘in action’ will be shared and discussed. The goal of the symposium is to foster lively scientific discussion, exchange of ideas and future collaborations. We have an exciting program including a distinguished group of international speakers, an interactive poster session and opportunities for oral presentations from students and postdoctoral fellows.

For more information and to register, visit the Immune Imaging Symposium website.

Could Your Sleep Position Help Reduce Alzheimer’s Risk?

Wednesday, August 5, 2015

Researchers at SUNY Stony Brook and The University of Rochester think so.

Sleeping in the lateral, or side position, as compared to sleeping on one’s back or stomach, may more effectively remove brain waste and prove to be an important practice to help reduce the chances of developing Alzheimer’s, Parkinson’s and other neurological diseases, according to researchers at Stony Brook University.

In the paper, “The Effect of Body Posture on Brain Glymphatic Transport,” Dr. Benveniste and colleagues used a dynamic contrast MRI method along with kinetic modeling to quantify the CSF-ISF exchange rates in anesthetized rodents’ brains in three positions – lateral (side), prone (down), and supine (up).

Dr. Benveniste and first-author Dr. Hedok Lee, Assistant Professor in the Departments of Anesthesiology and Radiology at Stony Brook developed the safe posture positions for the experiments. Their colleagues at the University of Rochester, including Lulu Xie, Rashid Deane and Maiken Nedergaard, PhD, used fluorescence microscopy and radioactive tracers to validate the MRI data and to assess the influence of body posture on the clearance of amyloid from the brains.

Read More: Could Your Sleep Position Help Reduce Alzheimer’s Risk?

Environmental Medicine News: EHSC Grant Renewal, New Appointment

Wednesday, July 29, 2015

Great news from Environmental Medicine—its Environmental Health Sciences Center (EHSC) core grant was recently renewed for the 41st straight year. The department ushered in the $7.5 million, five-year, EHSC award from the National Institute of Environmental Health Sciences (with a remarkable score of 12). She is also overseeing the setup of EHSC’s new epigenetics core facility. Funding for the Center began in 1975 and has been continuously supported by the NIH for costs related to infrastructure, career development, biostatistics, and to support collaborations across research departments at URMC.

Environmental Medicine also hired a new scientist with an interest in reproductive toxicity and epigenetics, a hot field concerned with investigating the environmental factors (such as the endocrine-disrupting chemical bisphenol A) that cause changes in gene expression across generations. Martha Susiarjo, Ph.D., completed a post-doctoral fellowship at the University of Pennsylvania and will join the UR as an assistant professor Sept. 1. She brings an NIH K99 award and expertise to the new epigenetics core facility.

The EHSC will celebrate 50 years of research with a two-day symposium Sept. 23-24, which will include a Science Café Series at the Pittsford Barnes & Noble, a poster session in Flaum Atrium, and a full slate of presentations at URMC from faculty and local civic leaders. Planning is under way; stay tuned for more details.

Work of Liz Romanski Recognized by the University Research Community

Thursday, July 23, 2015

Lizabeth Romanski

Researchers Pinpoint Brain's Audiovisual Processing Center

A new study is helping scientists more precisely understand how the brain stitches together sensory information such as sound and images, insight that could shed new light on conditions such as Autism. The research, which appears in the Journal of Neuroscience, identifies an area of the brain in the frontal lobe responsible for working memory and sensory integration.

Work in our laboratory is aimed at understanding how auditory and visual information are integrated since we know this process is crucial for recognizing objects by sight and sound, communicating effectively, and navigating through our complex world, said Lizabeth Romanski, Ph.D., an associate professor in the University of Rochester Department of Neurobiology and Anatomy and co-author of the study.

Our recent study demonstrates that the prefrontal cortex plays an essential role in audiovisual working memory, and when this area is switched off our ability to remember both the auditory and visual cues is impaired, said Bethany Plakke, Ph.D., a postdoctoral fellow in the Romanski lab and co-author of this study.

Read More: Work of Liz Romanski Recognized by the University Research Community

Babies' expectations may help brain development

Monday, July 20, 2015

Infants can use their expectations about the world to rapidly shape their developing brains, researchers have found.

A series of experiments with infants 5 to 7 months old has shown that portions of babies' brains responsible for visual processing respond not just to the presence of visual stimuli, but also to the mere expectation of visual stimuli, according to researchers from the University of Rochester and the University of South Carolina.

That type of complex neural processing was once thought to happen only in adults—not infants—whose brains are still developing important neural connections.

We show that in situations of learning and situations of expectations, babies are in fact able to really quickly use their experience to shift the ways different areas of their brain respond to the environment, said Lauren Emberson, who conducted the study at the University of Rochester's Baby Lab while a research associate with Richard Aslin in the department of brain and cognitive sciences.

For more information, visit the University of Rochester Newscenter.

Read More: Babies' expectations may help brain development

Researcher Wins Auditory Neuroscience Award

Tuesday, July 7, 2015

Laurel CarneyLaurel Carney, a professor of Biomedical Engineering, has been recognized for her work by the premier scientific organization in the field of acoustics. The Acoustical Society of America has awarded Carney the William and Christine Hartmann Prize in Auditory Neuroscience.

It's truly a great honor to receive an award created by Bill and Christine Hartmann, two of my role models, said Carney. I welcome the challenge to emulate their life of discovery, presentation, publication, service, and education throughout the world.

William and Christine Hartmann established the award with a donation to recognize and honor research that links auditory physiology with auditory perception or behavior in humans or other animals. William Hartmann is a physicist, psychoacoustician, and former president of the Acoustical Society of America. His contributions to the field involved pitch perception, signal detection, modulation detection, and the localization of sound.

In her research lab, Carney is working to better understand how the brain translates sounds into patterns of electrical impulses. By studying physiology, human hearing, and computer models, Carney hopes to learn how the brain distinguishes sounds in noisy environments and why even a small degree of hearing loss can lead to major problems. Her ultimate goal is to develop effective strategies to help people who have experienced hearing loss.

Carney earned her M.S. and Ph.D. degrees in electrical engineering at the University of Wisconsin-Madison. She was an associate professor of biomedical engineering at Boston University and professor of biomedical engineering at Syracuse University before joining the faculty at the University of Rochester in 2007, where she serves as professor in three departments—biomedical engineering, neurobiology and anatomy, and electrical and computer engineering.

For additional information, visit the Rochester Newsroom.

Flaum Eye Institute Scientist Gets Funding to Study Vision Loss in Batten Disease

Thursday, July 2, 2015

Ruchira Singh, PhD

Ruchira Singh, Ph.D.

University of Rochester Medical Center scientist Ruchira Singh, Ph.D., received a grant from the Knights Templar Eye Foundation to investigate how neurodegenerative diseases, such as juvenile Batten disease, cause blindness.

Singh, assistant professor of Ophthalmology and Biomedical Genetics, will use the $60,000 grant to create a human model of Batten disease (CNL3) using patient’s own cells. The project may lead to better understand the disease mechanisms, aiding in the development of drug therapies to preserve vision in affected patients.

For the complete article, visit the URMC newsroom.

Read More: Flaum Eye Institute Scientist Gets Funding to Study Vision Loss in Batten Disease

Mink Receives First Ever Tourette’s Association of America Award

Wednesday, July 1, 2015

Jon Mink, MD, PhD

Dr. Jonathan Mink

Jonathan Mink, M.D., Ph.D., chief of Child Neurology at Golisano Children’s Hospital, is the first recipient of the Tourette Association of America’s Oliver Sacks Award for Excellence. The award, named for the famous British neurologist, was to be presented at the First World Congress on Tourette Syndrome and Tic Disorders, but due to a scheduling conflict, representatives from TAA instead traveled to Rochester to present him with the award in a surprise ceremony.

The award is in recognition of his many years of leadership, mentorship, research, and care on behalf of all people touched by Tourette syndrome and tic disorders around the world.

$4M NIH Award Expands Joint Training of Deaf Scholars in Rochester

Friday, June 26, 2015

The University of Rochester School of Medicine and Dentistry has received nearly $4 million for a program that would serve as a national model to educate post-doctoral students who are deaf or hard-of-hearing.

The grant makes it possible to expand and strengthen an ongoing, unique relationship between the UR, Rochester Institute of Technology and RIT’s National Technical Institute for the Deaf to prepare deaf and hard-of-hearing scholars for careers in the biomedical and behavioral sciences. Two years ago the local institutions partnered to build a similar program for graduate students, facilitating the transition from master’s degree programs offered at RIT to Ph.D. programs at UR.

Read More: $4M NIH Award Expands Joint Training of Deaf Scholars in Rochester

B&B Department Mourns the Loss of Rose Burgholzer

Wednesday, June 24, 2015

It is with much sadness that we inform everyone of the passing of Rose Burgholzer, after a long and courageous battle with cancer. Rose worked at the University for 40 years, almost half of that as an administrator in our department. She was a dear friend and colleague and will be greatly missed. Many former students remember Rose fondly and have communicated with her during her illness, and she graciously received a steady stream of visiting faculty and staff in her home these past few years.

A Funeral Mass was held Wednesday, June 17, at St. Kateri at St. Margaret Mary Church in Rochester, with entombment at Holy Sepulchre Cemetery. Memorials may be directed to a charity of your choice. View her obituary and a slideshow from Rose's family.

Duje Tadin explains how understanding GPS can help you hit a curveball

Monday, June 22, 2015

Curveball

Our brains track moving objects by applying one of the algorithms your phone's GPS uses, according to researchers at the University of Rochester. This same algorithm also explains why we are fooled by several motion-related optical illusions, including the sudden break of baseball's well known curveball illusion.

Like GPS, our visual ability, although quite impressive, has many limitations, said the study's coauthor, Duje Tadin, associate professor of brain and cognitive sciences at the University of Rochester.

The new open-access study published in PNAS shows that our brains apply an algorithm, known as a Kalman filter, when tracking an object's position. This algorithm helps the brain process less than perfect visual signals, such as when objects move to the periphery of our visual field where acuity is low.

Read More: Duje Tadin explains how understanding GPS can help you hit a curveball

Upcoming NGP PhD Defenses

Monday, June 22, 2015

Two NGP students are presenting their defense seminars next week.

Wei Sun defends on Monday June 29th and Adam Pallus defends on July 1st

To read their abstracts, visit the Defense Seminars site.

Read More: Upcoming NGP PhD Defenses

Congratulations to Brianna Sleezer on becoming the first intern matched from URBEST!

Wednesday, June 17, 2015

Brianna Sleezer

Brianna Sleezer, NSC PhD student

Brianna Sleezer, a neuroscience PhD graduate student in the Hayden Lab, is URBEST's (Broadening Experiences in Scientific Training) first intern that has been matched with a host: The Children's Environmental Health Network. Brie made things happen by connecting with Nsedu Obot Witherspoon, the Executive Director for CEHN, at a URBEST Career Story. She'll be starting her three-month internship at the beginning of September.

URBEST is a five-year, NIH-funded program to help health science and biomedical PhD graduate students and postdoctoral appointees to explore and better prepare themselves for diverse career paths. The program combines educational activities to highlight research-related careers and to instruct in leadership and professionalism. The URBEST program also provides opportunities to a subgroup of trainees for short-term (hours per week) or long-term (full time for up to three month) internships as a capstone experience. Internship candidates are selected based on their research productivity, engagement in URBEST activities and PI approval.

Kerry O'Banion presents at the CTSI Workshop - Patent Infringement: COX Fighting

Sunday, June 14, 2015

Kerry O'Banion, interim chair of the Department of Neurobiology and Anatomy, and University President Emeritus Thomas Jackson will present Patent Infringement: COX Fighting, from noon to 1 p.m. Wednesday, June 17, in Helen Wood Hall Auditorium. The event is part of the CTSI workshop series, Good Advice: Case Studies in Clinical Research, Regulation, and the Law.

Read More: Kerry O'Banion presents at the CTSI Workshop - Patent Infringement: COX Fighting

Foxe Appointed to Head Neuromedicine Research at URMC

Tuesday, June 9, 2015

John FoxeJohn J. Foxe, Ph.D., a nationally-regarded scientist in the field of neurobiology, has been named the research director of the DelMonte Neuromedicine Institute (DNI) and the Kilian J. and Caroline F. Schmitt Chair of the Department of Neurobiology and Anatomy at the University of Rochester School of Medicine and Dentistry.

The University of Rochester has long been home to some of the nation’s most innovative and groundbreaking research in the field of neuroscience and neuromedicine, said Joel Seligman, president of the University of Rochester. John’s appointment signals our determination to make this field a centerpiece of our progress as a University and Medical Center.

I am honored to be taking the helm of the DNI at this incredibly exciting time in modern neuroscience research, said Foxe. The University of Rochester is already world-renowned for its superb work in this field and we now have the opportunity to build an even stronger presence. Tens of millions of Americans suffer from a major mental illness each year, be it depression or anxiety, a major psychotic disorder, or Alzheimer’s disease, stroke, or addiction. And the list goes on. The National Institutes of Health estimates that only about half of these people ever receive treatment. We can and we must do better. It is only through research that we can develop new effective treatments and I am committed to placing the DNI and the University of Rochester at the very forefront of these efforts.

Read More: Foxe Appointed to Head Neuromedicine Research at URMC

$10 Million Grant Funds Center to Study OCD at UR School of Medicine and Dentistry

Thursday, June 4, 2015

Suzanne HaberSuzanne Haber leads a research team to investigate OCD. She says the disease is characterized by intrusive, ruminating thoughts (obsessions), and impulses to carry out repetitive behaviors (compulsions), despite the awareness by most patients that these behaviors don't make sense.

The goal of a new $10 million grant awarded to the scientists is to improve our understanding of the brain networks that play a central role in obsessive-compulsive disorder (OCD). Together with leading mental health researchers at four other institutions in the U.S., they will pinpoint specific abnormalities within the brain circuits that are associated with the disease and use this information to guide new treatment options for the three million-plus Americans who live with the disorder.

The five-year grant from the National Institute of Mental Health (NIMH) establishes a new Silvio O. Conte Center for Basic and Translational Mental Health Research at the University of Rochester. Conte Centers are designed to bring scientists with diverse but complimentary backgrounds together to improve the diagnosis and treatment of mental health disorders.

Read More: $10 Million Grant Funds Center to Study OCD at UR School of Medicine and Dentistry

13 Things to Know About Biomedical Research at UR

Friday, May 29, 2015

The Democrat and Chronicle was one of 12 Gannett newspapers that partnered with a USA Today investigation, Biolabs in Your Backyard, about the concerns and dangers that can accompany biomedical research.

The investigation focused on more than 200 high-containment biomedical labs around the nation that are equipped to handle select agents and other dangerous research.

Research involving select agents is considered by the federal government to be the most worrisome biomedical lab work because of potential health risks and security concerns, especially since some of these agents and toxins can be used in biological warfare.

The University of Rochester has one high-containment lab at its medical center that in recent years has worked with Francisella tularensis, which is a Tier I select agent, the highest level of concern.

Read More: 13 Things to Know About Biomedical Research at UR

Pharmacology Speakers and Students Win Poster Awards at UNYPS

Tuesday, May 19, 2015

Congratulations to the following Graduate Students and Invited Student Speakers for winning poster awards at the 4th Annual Upstate New York Pharmacology Society (UNYPS) meeting G-Protein Coupled Receptor Signaling Systems in Health and Diseasewhich was held at the University of Rochester on May 19th, 2015. Graduate student winners were Hannah Stoveken, working in the lab of Dr. Gregory G. Tall Isaac Fisher, working in the lab of Dr. Alan V. Smrcka Alex Hajduczok, working in the lab of Dr. Gregory G. Tall and Rafael Gil de Rubio, working in the lab of Dr. Alan V. SmrckaInvited student speaker winners were Walter Knight, Bharti Patel, graduate student in the lab of Dr. Gregory G. Tall and Jesi Lee Anne To, graduate student in the lab of Dr. Alan V. Smrcka

Ben Crane Awarded Nicholas Torok Vestibular Award by the American Neurotology Society

Monday, May 11, 2015

Otolaryngology associate professor, Benjamin Crane, MD, PhD, was awarded the Nicholas Torok Vestibular Award by the American Neurotology Society at the 50th Annual meeting in Boston on April 25th. The title of his presentation was An automated vestibular rehabilitation method for unilateral vestibular hypofunction.

The $1500 award is offered by the Society for the best lecture on an innovative observation, experience or technique in the field of Vestibular Basic Science, i.e., physiology, pathology or subjects serving clinical progress.

Congratulations Ben!

Understanding the Enemy Within that Causes Brain Damage after Cardiac Arrest

Thursday, May 7, 2015

A new $1.7 million grant will bring together a team of researchers to study – an ultimately thwart – the chain reaction that occurs in the body after cardiac arrest that can ultimately lead to brain damage and death.

“While the biological sequence of events is triggered by cardiac arrest, the death and disability associated with this event is the result of a broader systemic injury caused the initial loss of blood flow and subsequent tissue inflammation once blood circulation is restored,” said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. In fact, it is the cumulative effect of this systemic injury on the brain, and not the heart – that ultimately leads to mortality in the disorder.

Read More: Understanding the Enemy Within that Causes Brain Damage after Cardiac Arrest

2015 Awards Announced

Wednesday, May 6, 2015

The 2015 Vincent duVignaeud Award for excellence in basic research will be awarded at this year’s commencement to Dr. Steven Baker who completed his Ph.D. in Luis Martinez-Sobrido’s lab.

The 2015 Wallace O. Fenn Award for excellence in basic research will be awarded at this year’s commencement to Dr. Julie Sahler who completed her Ph.D. in Richard Phipps’ lab.

Award Recipients for the Melville A. Hare Award for Excellence in Research have been awarded to Dr. Denise Skrombolas who completed her Ph.D. in the lab of John Frelinger and Dr. Benson Cheng who completed his Ph.D. in Luis Martinez-Sobrido’s lab.

The Melville A. Hare Award for Excellence in Teaching has been awarded to Jennifer Colquhoun. Jennifer is in Paul Dunman’s laboratory.

A Departmental Peer Mentoring Award was established this year. The recipient of the 2015 award is Lisbeth Boule. Lisbeth is in Paige Lawrence’s laboratory.

Professors Dalecki and Hocking Research Wins Best Paper Award at SPIE-DSS

Wednesday, May 6, 2015

The latest research by Professor Diane Dalecki (BME, RCBU) and Professor Denise C. Hocking (Pharmacology & Physiology, BME, RCBU) was recognized with the Best Paper Award at the Micro- and Nanotechnology Sensors, Systems, and Applications Conference of the SPIE Defense + Security Symposium held recently in Baltimore, Maryland. Their invited paper titled “Guiding Tissue Regeneration with Ultrasound In Vitro and In Vivo” detailed three biomedical ultrasound technologies under development in their laboratories to stimulate tissue formation and regeneration. Co-authors of the paper included Sally Child, Carol Raeman, and BME graduate students Eric Comeau and Laura Hobbs. One technology under development employs forces within an ultrasound standing wave field to provide a noninvasive approach to spatially pattern endothelial cells and thereby guide the development of complex microvessel networks. A second technology uses ultrasound to site-specifically control the microstructure of collagen fibers within engineered hydrogels to direct cell function. The third line of research focuses on developing ultrasound as a therapeutic approach to enhance tissue regeneration in chronic wounds. These ultrasound technologies offer new solutions to key challenges currently facing the fields of tissue engineering, biomaterials fabrication, and regenerative medicine.

The SPIE DSS 2015 Defense + Security Symposium consisted of 32 separate conferences spanning 5 days with over 1200 total presentations. Conferences focused on a wide range of topics of interest to defense and security, including imaging, sensing, photonics, materials, and biomedical applications. The Symposium is the leading meeting for scientists, researchers and engineers from industry, military, government agencies, and academia throughout the world. The Micro- and Nanotechnology Sensors, Systems, and Applications Conference is one of the two largest conferences within the entire Defense + Security Symposium, and Professors Hocking’s and Dalecki’s presentation was one of over 100 invited presentations in the conference.

Lower Air Pollution, Higher Birth Weight

Tuesday, May 5, 2015

A team of researchers led by Associate Professor, Dr. David Rich (Public Health Sciences & Environmental Medicine) studied birth weights before, during and after the Beijing Olympics, during which widespread pollution reduction efforts were instated. They found infants born shortly after the Olympics had significantly higher birth weights than infants born in other years. The researchers compiled information from 83,672 term births (37 to 42 weeks gestational age at birth) to mothers in four urban districts in Beijing. They compared birth weights for mothers whose eighth month of pregnancy occurred during the 2008 Olympics/Paralympics with those whose eighth month of pregnancy occurred at the same time of year in the years before (2007) and after (2009) the games when pollution levels were at their normally higher levels. They found that the babies born in 2008 were on average 23 grams larger than those in 2007 and 2009.

Read More: Lower Air Pollution, Higher Birth Weight

Rianne Stowell Receives Honorable Mention for NSF Research Fellowship

Friday, May 1, 2015

Rianne Stowell

Rianne Stowell, Ph.D. candidate

Four University of Rochester graduate students and seven alumni have been named recipients of the National Science Foundation Graduate Research Fellowships. Additionally, five current students and 11 recent alumni were given honorable mentions by the NSF.

The fellowship, which is part of a federally sponsored program, provides up to three years of graduate study support for students pursing doctoral or research-based master’s degrees. Since the program’s inception in 1952, NSF has provided fellowships to individuals selected early in their graduate careers based on their demonstrated potential for significant achievements in science and engineering. Of the more than 16,500 applicants this year, only 2,000 were awarded fellowships. The fellowship includes a three-year annual stipend of $34,000, a $12,000 educational allowance to the institution, and international research and professional development opportunities for recipients.

Congratulations Rianne on the honorable mention!!

For the complete list of recipients, visit the story at the UR Newsroom.

Read More: Rianne Stowell Receives Honorable Mention for NSF Research Fellowship

Rochester team receives National Eye Institute grant for restoring vision through retinal regeneration

Friday, May 1, 2015

David Williams

David Williams, the William G. Allyn Professor of Medical Optics, Dean for research and Director of the Center for Visual Science

A team of researchers at the University of Rochester is designing an optical system to image responses to light of large numbers of individual cells in the retina, with the objective of accelerating the development of the next generation of cures for blindness. The Rochester team and their partners will receive $3.8 million from the National Eye Institute over the next five years.

The new instrumentation we are developing builds on technology we had developed previously to improve vision through laser refractive surgery and contact lenses, as well as to diagnose retinal disease, said Rochester's principal investigator David Williams. This is the first time we have designed instrumentation specifically to develop and test therapies to restore vision in the blind.

The National Eye Institute (NEI), part of the National Institutes of Health, announced the awards as part of its Audacious Goals Initiative to tackle the most devastating and difficult to treat eye diseases. The central goal is to restore vision by regenerating neurons and neural connections in the eye and visual system. The initiative places special emphasis on cells of the retina, including the light-sensitive rod and cone photoreceptors, and the retinal ganglion cells, which connect photoreceptors to the brain via the optic nerve.

For the entire article, visit the University Newscenter.

Read More: Rochester team receives National Eye Institute grant for restoring vision through retinal regeneration

URMC Start-up Takes Aim at Memory and Cognitive Problems

Thursday, April 30, 2015

Medications are available to treat many of the symptoms of neurodegenerative diseases like multiple sclerosis and Parkinson’s disease, but there is no drug or other therapy that improves the memory and cognitive problems that often plague patients. A new start-up company, built around research conducted at the University of Rochester School of Medicine and Dentistry, hopes to change that.

Camber NeuroTherapeutics Inc., founded based on discoveries made in the laboratories of Harris "Handy" A. Gelbard, M.D., Ph.D. and Stephen Dewhurst, Ph.D., plans to attack the cognitive component of neurodegenerative diseases using a completely new approach: stopping the inflammation in the brain, so-called neuroinflammation, that impairs the function of nerve cells and the vast networks they create. These neural networks allow us to store and recall memories, plan and prioritize, focus on particular tasks, and process sensory information.

Read More: URMC Start-up Takes Aim at Memory and Cognitive Problems

Dr. David Yule invited to join Editorial Board of Gastroenterology

Wednesday, April 29, 2015

David I. Yule, Ph.D., Professor of Pharmacology and Physiology; of Medicine, Gastroenterology/Hepatology; and in the Center for Oral Biology has been invited to join the Editorial Board of Gastroenterology. Gastroenterology is the preeminent journal in the field of gastrointestinal disease. Gastroenterology is ranked 1st of 74 journals in the Gastroenterology and Hepatology category on the 2013 Journal Citation Reports, and has an Impact Factor of 13.926. As the official journal of the American Gastroenterological Association, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology. Regular features include articles by leading authorities and reports on the latest treatments for diseases. Original research is organized by clinical and basic-translational content, as well as by alimentary tract, liver, pancreas, and biliary content.

Melinda Vander Horst presents at NCUR

Wednesday, April 29, 2015

Melinda Vander Horst (BME Class 2015) presented her recent research at the 29th Annual National Undergraduate Research Conference (NCUR) held at Eastern Washington University in April. NCUR is an interdisciplinary conference where undergraduate students representing universities from around the world present their research and creative works. Melinda presented her poster, titled Development of a dual transducer system for ultrasound standing wave field-induced particle banding, with co-authors Eric Comeau (BME graduate student), Denise C. Hocking (Pharmacology & Physiology), and Diane Dalecki (BME). Melinda is a Xerox Undergraduate Research Fellow working with Professors Dalecki and Hocking on new ultrasound technologies for tissue engineering.

Anolik Elected to American Society for Clinical Investigation

Monday, April 27, 2015

Dr. Jennifer Anolik with MSTP Director, Dr. Kerry O'Banion

Dr. Jennifer Anolik with
MSTP Director, Dr. Kerry O'Banion

Jennifer H. Anolik, M.D., Ph.D., associate professor of Medicine in the Division of Allergy/Immunology and Rheumatology, was named a member of the American Society for Clinical Investigation, one of the nation’s oldest and most respected medical honor societies. Anolik, who runs URMC’s Lupus Clinic and Program, was nominated for her work conducting translational and basic science research on lupus and rheumatoid arthritis. She joins 18 other Medical Center faculty members who have been inducted into the Society in the past. Anolik is a former URMC MSTP (M.D., '96) and Biochemistry (Ph.D., '94) student. During her time in the program, she conducted research with Robert Bambara, Ph.D. and Russell Hilf, Ph.D..

Anolik’s research focuses on the role of B cells in systemic autoimmune disease through synergistic and innovative approaches in translational immunology and animal models. It has fundamentally contributed to the understanding of how and why B cell targeted therapies can be efficacious in subsets of lupus and rheumatoid arthritis patients and established these therapies as a major advance in the field of immunologic disease. Her work has broad implications for other autoimmune diseases such as vasculitis and diabetes, as well immunologic diseases like malignancy and immune deficiency.

Under Anolik’s leadership, URMC was one of 11 research groups across the country recently chosen by the National Institutes of Health to join the NIH Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, a partnership between the NIH, biopharmaceutical companies, advocacy organizations and academic scientists to more rapidly identify promising drug targets and develop new treatments for patients with these conditions. Anolik’s team was selected for this highly competitive award based on the novelty of their translational research proposal coupled with the unique collaboration between Orthopaedics and Rheumatology at URMC.

Read the entire press release.

Does Artificial Food Coloring Contribute to ADHD in Children?

Monday, April 27, 2015

Kraft Macaroni & Cheese -that favorite food of kids, packaged in the nostalgic blue box—will soon be free of yellow dye. Kraft announced Monday that it will remove artificial food coloring, notably Yellow No. 5 and Yellow No. 6 dyes, from its iconic product by January 2016. Instead, the pasta will maintain its bright yellow color by using natural ingredients: paprika, turmeric and annatto (the latter of which is derived from achiote tree seeds).

The company said it decided to pull the dyes in response to growing consumer pressure for more natural foods. But claims that the dyes may be linked to attention-deficit hyperactivity disorder (ADHD) in children have also risen recently, as they did years ago, putting food dyes under sharp focus once again. On its Web site Kraft says synthetic colors are not harmful, and that their motivation to remove them is because consumers want more foods with no artificial colors.

Bernard Weiss, professor emeritus of the Department of Environmental Medicine at the University of Rochester Medical Center who has researched this issue for decades, says he is frustrated that the FDA has not acted on the research showing the connection between artificial dyes and hyperactivity. All the evidence we have has showed that it has some capacity to harm, he says. In Europe that's enough to get it banned because a manufacturer has to show lack of toxic effects. In this country it's up to the government to find out whether or not there are harmful effects. Weiss supports banning artificial colors until companies have evidence that they cause no harm. Like most other scientists in this field, he thinks more research, particularly investigating dyes' effects on the developing brain, is imperative.

Read More: Does Artificial Food Coloring Contribute to ADHD in Children?

NGP Graduate Student, Grayson Sipe, Wins Award for Excellence in Teaching

Monday, April 27, 2015

Grayson Sipe Receiving Edward Peck Curtis Award

Grayson Sipe, Ph.D. candidate and Margaret H. Kearney, PhD, RN, FAAN, Professor and Vice Provost & University Dean of Graduate Studies.

Grayson Sipe, a Neuroscience Graduate Program student in Dr. Ania Majewska's lab, studying the roles of microglia during synaptic plasticity, has been named a winner of the 2015 Edward Peck Curtis Award for Excellence for Graduate Student Teaching.

Only a handful of these are awarded each year, and all this year's nominees were extremely well-qualified.

Congratulations Grayson!!!

Maquat and Kurosaki Awarded Fellowship

Friday, April 24, 2015

Lynne Maquat, the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, and Research Assistant Professor, Tatsuaki Kurosaki, Ph.D. have been awarded FRAXA Postdoctoral Fellowship for their application entitled, Re-purposing clinically approved drugs to dampen hyperactive nonsense-mediated mRNA decay in fragile X syndrome.

The FRAXA Research Foundation was extremely impressed with their proposed research, and delighted to support this exciting work. Funding of 45,000 has been authorized for the period from May 1, 2015 to April 30, 2016.

Congrats to both Lynne and Tatsuaki!

Gloria Culver, Biochemistry Program Graduate, Appointed Dean of the School of Arts & Sciences

Wednesday, April 22, 2015

Gloria Culver, former Biochemistry graduate student in the Phizicky Lab, has been appointed dean of the School of Arts & Sciences, effective immediately. Culver is currently a professor of Biology and Biochemistry & Biophysics. Peter Lennie, the Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences & Engineering, made the announcement following a yearlong national search. Culver has been serving as interim dean since July 1, 2014.

Read More: Gloria Culver, Biochemistry Program Graduate, Appointed Dean of the School of Arts & Sciences

Harold Smith Awarded Drug Development Pilot Award

Tuesday, April 14, 2015

Biochemistry & Biophysics Professor, Harold Smith, PhD has been awarded a Drug Development Pilot Award for his project, Development of an Assay for High Throughput Screening for Antagonists of the Ebola VP40 Protein Function. The project was externally reviewed by leading drug development researchers and received a meritorious score. To learn about Dr. Smith's research please visit the Smith lab site.

Congrats Harold!

Celebrating 50 Years at URMC and Saying Goodbye: Victor Laties

Friday, April 10, 2015

Dr. Victor Laties, Professor Emeritus

Dr. Victor Laties, Professor Emeritus

In 1965, a young Victor Laties left Johns Hopkins for the University of Rochester and never looked back. In 2015, Vic celebrated his 50th year at the University of Rochester Medical Center-a feat not surpassed by many. Primarily in the department of Environmental Medicine, Vic has touched many lives over the years with his great work ethic, caring attitude, his love of toxicology, and his fantastic photos that have graced the Environmental Medicine, Environmental Health Sciences Center (EHSC), and Toxicology websites over the past 50 years.

The first director of the toxicology training grant, that is now in his 37th year, Vic has been integral to it's success and has created many memories and passed down a wealth of knowledge to hundreds of students. Beginning in the departments of Biophysics, Psychology, and Pharmacology Vic has also made many a friend and has been a valued colleague to his peers. Vic has remained on the editorial board for the Journal of the Experimental Analysis of Behavior since 1962 (and the webmaster for the JEAB/JABA site), and has served as editor for several other experimental therapeutics and pharmacological journals throughout the years.

Vic won the Distinguished Service to Behavior Analysis Award from the Society for the Advancement of Behavior Analysis (SABA) in 1995 and 2003-the only person to win this award twice. He was a major figure in the development of both behavioral pharmacology and behavioral toxicology. His work with the Society for the Experimental Analysis of Behavior (SEAB) journals has been essential to their development and their sustained excellence over the last forty years. To date he has published well over 100 journal articles, book chapters and various other publications.

Vic's love of toxicology and the department is surpassed only by his love for his wife and family as he officially retires today and moves to Maryland to be closer to them and enjoy the nice weather. The department and all of his colleagues wish to express their heartfelt gratitude for the many years of service and contributions that he has given. He is truly one of a kind and will be missed.

To read more about Vic's many accolades please see the Association for Behavior Analysis International article and view his CV.

Vic and the Environmental Medicine, Toxicology and EHSC Staff

Vic and the Environmental Medicine, Toxicology and EHSC Staff

Lynne Maquat to Present Annual Hoffman Lecture

Thursday, April 9, 2015

Lynne Maquat, the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, will present the 17th annual Marvin J. Hoffman Lecture, "RNA and the New Genetics: From Bench to Therapeutics." The lecture begins at noon Friday, April 17, in the Class of '62 Auditorium (G-9425), Medical Center. RSVP to 273-5937 or apullen@admin.rochester.edu.

Brittany Baisch, PhD ’13 Wins Nanotoxicology Specialty Section Best Publication 2015 Award

Wednesday, April 8, 2015

Former Toxicology graduate student in Alison Elder's lab, Brittany Baisch (PhD ’13) won the Nanotoxicology Specialty Section Best Publication 2015 Award at the Society of Toxicology (SOT) annual meeting in San Diego, CA. last week. She won the award for the paper, Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Brittany is currently working as a toxicologist at Kraft Foods.

Celebrating Brain Awareness Week!

Wednesday, April 8, 2015

Brain Awareness Week 2015

NGP student (with the support of PONs and SfN Rochester Chapter) organized the annual Brain Awareness Week and provided activities for grades K-3 at area schools.

Over the span of 2 weeks, from March 16-27, NGP students visited 19 classrooms at three different schools (Colebrook School in Irondequoit, Indian Landing in Penfield and West Ridge in Greece), grades K-4 working with over 350 kids!

They brought activities to the kids that focused on signal transduction, memory and perception. There was a team of 35 volunteers, including BCS and neuroscience undergrad and grad students that traveled to the schools. 6 NGP students were among the volunteers (Julianne Feola, Christy Cloninger, Jenn Stripay, Becky Lowery, Ryan Dawes and Susanne Pallo) participating in the planning and organization of the activities, school visits and training sessions.

Visit the Brain Awareness Week Facebook page for more information.

Read More: Celebrating Brain Awareness Week!

Marissa Sobolewski Wins Butcher New Investigator Award and 2nd Place Postdoctoral Fellow Poster Award at SOT

Friday, April 3, 2015

Marissa Sobolewski

Postdoctoral Fellow in the Cory-Slechta lab, Marissa Sobolewski, PhD finished second in the Neurotoxicology SS Toshio Narashashi Postdoctoral Fellow Poster Award at the Society of Toxicology (SOT) annual meeting in San Diego, CA. last week.

Marissa also recently won the Richard Butcher New Investigator Award from the Neurobehavioral teratology society. Her research focus is Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity. Congrats!

UR Toxicology Graduate Students Make Strong Showing at 2015 SOT Meeting

Friday, April 3, 2015

Dr. Alison Elder and Elissa Wong

Dr. Alison Elder and Elissa Wong

UR Toxicology graduate students made a strong showing at the Society of Toxicology (SOT) annual meeting in San Diego, CA. last week. 3rd year graduate student, Elissa Wong (Majewska Lab) and 5th year graduate student, Sage Begolly (O'Banion/Olschowka Labs) both won travel awards to attend and present their posters.

Elissa Wong and Dr. Alison Elder also attended the event, hosting the UR recruitment table at the Society of Toxicology (SOT) Committee on Diversity Initiatives (CDI) session. Congrats to all!

View all of the photos from the SOT meeting.

Former IGPN student Laurie Robak, M.D., Ph.D. Receives Fellowship Award

Monday, March 30, 2015

Laurie Robak, MD, PhD

Laurie Robak, MD, PhD

Laurie Robak, MD, PhD, who graduated from the IGPN program in 2009, is a clinical fellow in the Laboratory for Integrative Functional Genomics, and is also currently completing her dual residency training in pediatrics and medical genetics. July 1st of this year, Laurie will be a postdoctoral research associate/clinical instructor in the laboratory of Dr. Joshua Shulman at Baylor Medical College, researching the genetics of Parkinson’s disease. Laurie recently received the Pfizer/ACMG Foundation Translational Genomic Fellowship Award.

Congrats Laurie!

Robert Dirksen to Head Department of Pharmacology and Physiology

Monday, March 30, 2015

Robert T. Dirksen, Ph.D. will serve as chair of the Department of Pharmacology and Physiology at the University of Rochester School of Medicine and Dentistry effective July 1, 2015, pending approval by the University Board of Trustees. Dirksen, who has conducted research and taught medical and graduate students at the University since 1998, is known for his superb track record of federal funding, his collaborative nature and his ability to inspire and engage trainees and colleagues alike.

“Bob recognizes the central role that Pharmacology and Physiology plays in much of the research that is conducted at the Medical Center and has a very clear and compelling vision for the future of the department,” said Mark B. Taubman, M.D., Dean of the School of Medicine and Dentistry and CEO of the University of Rochester Medical Center. “He is the perfect person to lead a group that bridges multiple scientific fields and clinical areas and we’re very excited for him to take the reins.”

Read More: Robert Dirksen to Head Department of Pharmacology and Physiology

Blocking Cellular Quality Control Mechanism Gives Cancer Chemotherapy a Boost

Friday, March 27, 2015

A University of Rochester team found a way to make chemotherapy more effective, by stopping a cellular quality-control mechanism, according to a study published today in Nature Communications.

The mechanism is known as NMD (nonsense-mediated mRNA decay), and scientists found that exposing breast cancer cells to a molecule that inhibits NMD prior to treatment with doxorubicin, a drug used to treat leukemia, breast, bone, lung and other cancers, hastens cell death.

The research team, led by Lynne E. Maquat, Ph.D., director of the Center for RNA Biology at the University of Rochester, acknowledges that the work is in the early stages and a long way from being applied in humans. But, they believe their data provide insights that could lead to new treatment strategies for cancer patients in the future.

Read More: Blocking Cellular Quality Control Mechanism Gives Cancer Chemotherapy a Boost

Lynne Maquat Receives 2015 Gairdner International Award

Thursday, March 26, 2015

Lynne E. Maquat, Ph.D. received the 2015 Gairdner International Award for the discovery and mechanistic studies of nonsense-mediated mRNA decay, a cellular quality control mechanism that derails the production of unwanted proteins in the body that can disrupt normal processes and initiate disease. She is one of five scientists honored with the award, which is given every year to recognize the achievement of medical researchers whose work contributes significantly to improving the quality of human life.

The J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics at the University of Rochester Medical Center, Maquat is known around the world for her work on nonsense-mediated mRNA decay, which is critically important in both normal and disease states. She is considered the uncontested pioneer on the subject and in 2011 was elected to the National Academy of Sciences for her exceptional research, which has been published in more than 130 peer-reviewed scientific articles.

Maquat is the first scientist from upstate New York to receive the Gairdner International Award, which is recognized for its rigorous peer-led selection process. A panel of active Canadian scientists reviews all nominations and passes their recommendations to a board of two dozen senior scientists from across Canada, the United States, Europe, Australia and Japan. After in-depth study and review, board members cast votes for the nominees whose achievements rise above all others in their field. According to the Gairdner Foundation, of the 313 winners to date, 82 have gone on to receive a Nobel Prize in Physiology or Medicine, a testament to the quality of the awardees.

The award was also highlighted in the Opinion pages of Saturday’s Democrat and Chronicle in the Thumbs up, thumbs down section: Thumbs up: For Dr. Lynne Maquat, who is one of five biomedical researchers from around the world to win this year's Gairdner International Award. The University of Rochester Medical Center scientist has joined a prestigious group. Since 1959, more than a quarter of the Gairdner International winners have gone on to win a Nobel Prize, too.

Read More: Lynne Maquat Receives 2015 Gairdner International Award

B&B Graduate Students 'Bootleg' Their Way to the Top

Friday, March 20, 2015

The Pocket Radio Theater

The Biochemistry and Biophysics department is pleased to announce that a number of the department's graduate students have undertaken a very creative project. Specifically, six of our graduate students have been writing, producing, and voice acting in a serial podcast about bootleggers smuggling rum across Lake Ontario in 1921.

You can access the first three episodes on iTunes, or you can find them on their Pocket Radio Theater Facebook page. While contingent on their individual research workloads, their plan is to release more episodes on a monthly basis for a total of around 20.

Check out the creative endeavors of your departmental colleagues!

Stoveken, Lerman Win Awards at Falling Walls Competition

Tuesday, March 17, 2015

Congratulations to Hannah Stoveken, Graduate student in the lab of Gregory G. Tall Associate Professor of Pharmacology and Physiology, who took second place in the University's First Falling Walls Competition and $300. Honorable mention went to Yelena Lerman, a graduate student working with Minsoo Kim, Associate Professor of Microbiology and Immunology. Full article in Research Connections at the University of Rochester can be found here

WATCH: NY Med Schools Ask Legislature to Invest in Retention of Top Biomedical Researchers

Monday, March 16, 2015

Medical Schools in New York State are asking the legislature to include $50 million for faculty development in the state budget. University leadership calls the NYSTAR Faculty Development Program an investment needed to grow programs that will attract high-profile entrepreneurial biomedical researchers.

Read More: WATCH: NY Med Schools Ask Legislature to Invest in Retention of Top Biomedical Researchers

Microbiologist Barbara Iglewski Named to National Women’s Hall of Fame

Thursday, March 12, 2015

Barbara H. Iglewski, Ph.D., professor emeritus in the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry will be inducted into the National Women's Hall of Fame later this year, an incredible honor that puts her aside women’s rights activist Susan B. Anthony, former first lady Betty Ford, and founder of the Susan G. Komen Breast Cancer Foundation Nancy Brinker.

Read More: Microbiologist Barbara Iglewski Named to National Women’s Hall of Fame

Congratulations to Nguyen Mai

Tuesday, March 10, 2015

Nguyen MaiCongrats to Nguyen Mai, MD/PhD student, in Dr. Marc Halterman's lab for receiving an individual fellowship F30 from NIH's National Institute of Neurological Disorders and Stroke for her work on Role of lung-brain coupling on neutrophil priming and reperfusion injury following global cerebral ischemia.

VasoMark advances to the next phase!

Tuesday, March 10, 2015

The VasoMark Team

The VasoMark Team

A group of students from Neuroscience Graduate Program and Neurosurgery Residency Program have teamed up to compete in the National Institutes of Health Neuro Startup Challenge. This new effort offers pre- and post-doctoral students from biomedical, legal, and business backgrounds the opportunity to compete for licenses to patented technologies from the NIH portfolio.

The teams model a business around the intellectual property, and seek startup funding from partnering angel investor and venture capitalist firms in order to bring the proposed technology to the biomedical marketplace. The NGP and Neurosurgery team, named VasoMark, selected two patents for the development of a minimally invasive diagnostic for the detection of primary and recurrent malignant brain tumors. VasoMark successfully completed Phase I of the competition, where they developed a two-minute elevator pitch and executive summary describing their intended entrepreneurial use of the selected technology. They are currently developing a business plan and live investor pitch describing their business model, intended market, and future areas of expansion for their selected patents.

Department Announces Fred Sherman Student Award

Friday, March 6, 2015

The Department of Biochemistry & Biophysics are very pleased to announce a new student award within the Biochemistry and Molecular Biology program, to be given at our annual Awards Ceremony in May.

The Fred Sherman Award will honor the memory of our former colleague, and will annually recognize a student in the BMB program who exemplifies the imagination, the excellence in the pursuit of scientific knowledge, and the commitment to the scientific community that were characteristic of Fred Sherman.

This award will compliment the William F. Neuman Award, given annually to a BSCB student to recognize academic, scientific and personal qualities which exemplify the imagination, enthusiasm and excellence in the pursuit of scientific knowledge which were characteristic of the life of Dr. William F. Neuman.

Anna Bird Awarded Pilot Project Grant

Thursday, March 5, 2015

Anna Bird, an IMV graduate student in the Anolik lab has been awarded pilot project grant through the Pilot Studies Program of the CTSI. Anna’s application entitled, “Neutrophils as a driver of inflammation in lupus bone marrow” was felt to be highly meritorious and received a priority score enabling her proposal to be funded.

Mini-symposium for Young Investigators in Memory of Dr. Robert Marquis to be Held March 10, 2015

Monday, March 2, 2015

Robert Marquis Mini-Symposium for Young Investigators
Tuesday, March 10, 2015
Hynes Convention Center, Boston, MA

About Robert Marquis

Dr. Robert E. Marquis, PhD, was chair of the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry, and a beloved teacher to many students who trained at the medical school and at the university’s College of Arts and Sciences. He died in January 2014 at the age of 80. Originally from Ontario, Canada, “Bob” earned his M.S. and PhD degrees from the University of Michigan in Ann Arbor. He spent two years as a post-doctoral fellow at the University of Edinburgh in Scotland, where he studied under the guise of Peter Mitchell, a British biochemist who was awarded the 1978 Nobel Prize in Chemistry.

Bob began his career at the University of Rochester in 1963 as a senior instructor in Microbiology and was continuously funded by the National Institutes of Health until his retirement as a professor in 2012. During his early years at the medical school, he studied energy transduction – how cells and bacteria develop energy from food. From the 1970s until the end of his career he focused on oral streptococci, a type of bacteria present in the mouth that are major contributors to tooth decay. He had a secondary appointment in the Center for Oral Biology and his work on the effects of fluoride on cavity-producing bacteria earned him international recognition and the 2006 Distinguished Scientist Award for Research in Dental Caries from the International Association for Dental Research.

As passionate as Bob was about his research, he was equally, if not more passionate about the colleagues, trainees, and students he worked with every day. He influenced the lives of many graduate students who considered him to be a remarkable colleague, mentor and friend. It is not surprising then that many of Bob’s graduate students went on to assume distinguished careers in academia, industry, or public health service.

Bob's influence also included undergraduate students on the University of Rochester’s River Campus, where he was a founding director of the Undergraduate Program in Biology and Medicine. This program combines the College of Arts and Sciences and the School of Medicine and Dentistry to provide courses for undergraduate students with lectures, laboratory work, specialty seminars and research experiences. Bob helped start the program in the early 1980’s and it led to the creation of the Bachelor’s of Science degrees in Biological Sciences, which includes tracks in Biochemistry, Cell and Developmental Biology, Ecology and Evolutionary Biology, Microbiology, Molecular Genetics, and Neuroscience. Thanks to Bob’s work, the program is a major conduit for undergraduate students into research labs at the medical school.

Outside of the University, Bob loved the Rochester Philharmonic Orchestra and was a huge fan of theater, traveling annually to the Shaw Festival in Niagara-on-the-Lake and the Shakespeare Festival in Stratford, Ontario. He was also known to fly to London with his wife on a regular basis to catch plays in London’s West End. Another hobby was custom brewing, an art that he shared and passed on to many.

Purpose

This mini-symposium honors the memory of the late Robert E. Marquis and the knowledge he eagerly shared with students, trainees and early career faculty members. Its main objective is to promote information exchange among scientists who engage in oral microbiology and immunology research and clinical studies pertaining to oral health and disease, and to provide a forum through which new investigators entering the field can network with established investigators and so create contacts that can help nurture their research progress and productivity.

Scientific Program

8:00 am Continental Breakfast and Sign-in

8:30 am Dr. Robert Quivey, PhD, Professor and Director, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY

 “Well actually……, 40 years of bacterial physiology, from the late Robert E. Marquis.”

9:00 am Alejandro Aviles-Reyes, PhD candidate, (2015 recipient of the Arnold Bleiweis Travel Grant), University of Rochester School of Medicine and Dentistry, Rochester, NY 

 “S. mutans modification of Cnm by a novel glycolytic pathway” 

9:25 am Dr. Roger M. Arce, DDS, MS, PhD, Assistant Professor, Dept. of Periodontics, College of Dental Medicine, Georgia Regents University, Augusta, GA

 “Exploring the in-vivo effects of pathogen-differentiated dendritic cells”

9:50 am Dr. Lauren Mashburn Warren, PhD Senior Research Scientist, Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH 

 “A novel approach to target the removal of caries-causing bacteria.”

10:15 am Dr. Octavio Gonzalez, DDS, MS, PhD, Assistant Professor, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY  “Adult and aged periodontitis: Two clinically similar but molecularly different lesions.”

10:40 am Dr. Peng Zhou, PhD, Associate Research Scientist, Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK

 “Role of veillonellae catalase in oral biofilm ecology”

11:05 am Dr. Brendaliz Santiago, PhD, Post-doctoral fellow, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY

 “Amino acid metabolism: Acid adaptation and transcriptional regulation in S. mutans.”

11:30 am Natasha Singh, DDS candidate, University of Toronto Faculty of Dentistry, Toronto, Ontario, CANADA

 “Development of a novel surveillance method to monitor bacterial biomarkers under chronic periodontitis.”

11:55 am Yun-ji Kim, Master’s candidate, School of Dentistry, Department of Oral Microbiology and Immunology, Seoul National University, Seoul, Republic of Korea

 “Dysbiosis of oral microbiota in recurrent aphthous ulcers.”

12:20 pm Dr. Jessica Kajfasz, Postdoctoral Associate, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY

 “Transcription of oxidative stress genes is directly activated by SpxA proteins of Streptococcus mutans.”

12:45–1:15pm: Lunch and Discussion

1:20 pm Stephen Kasper, PhD candidate, (2015 recipient of the Susan Kinder Haake Award) SUNY College of Nanoscale Science and Engineering, University of Albany, Albany, NY 

 “Natural product-based nanocapsules for sustained delivery of anti-biofilm agents”

1:45 pm Josefine Hirschfeld, DMD, Periodontology Resident/Research Associate, University Hospital Bonn, Bonn, Germany

 “Role of macrophage migration inhibitory factor in periodontal tissue destruction.”

2:10 pm Christina Sim, PhD candidate, National Dental Centre of Singapore, Singapore

 “Development of an in vitro polymicrobial biofilm model of dental caries.”

2:35 pm Keum Jin Baek, Master’s candidate, School of Dentistry, Department of Oral Microbiology and Immunology, Seoul National University, Seoul, Republic of Korea

 “Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis”

3:00 pm Dr. Zhimin Feng, Senior Instructor, Case Western Reserve School of Dental Medicine, Cleveland, OH

 “Further studies of Acinetobacter baumannii interaction with human oral epithelial cells: Invasive capacity and induction of hBD3.”

3:25–3:35pm Coffee/Refreshment Break

3:35 pm Dr. Samta Jain, PhD, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA

 “Trafficking of Porphyromonas gingivalis virulence factor Kgp to human endothelial cells.”

4:00 pm Dr. Kenneth Barth, PhD, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA

 “Porphyromonas gingivalis gingipain-mediated modification of cellular kinases impairs host innate immune signaling.”

4:25 pm Dr. Carolyn Kramer, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA

 “The Oral Microbiome in Patients with Oral Cancers.”

4:50 pm Dr. George Papadopolous, PhD candidate, Boston University Department of Medicine, Boston, MA

 “Pathogen-induced Th17 cells link oral infection with systemic inflammation.”

5:15 pm Concluding Remarks

E-Cigarette Vapors, Flavorings, Trigger Lung Cell Stress

Wednesday, February 11, 2015

Do electronic cigarettes help people quit smoking? As the debate continues on that point, a new University of Rochester study suggests that e-cigarettes are likely a toxic replacement for tobacco products.

Emissions from e-cigarette aerosols and flavorings damage lung cells by creating harmful free radicals and inflammation in lung tissue, according to the UR study published in the journal PLOS ONE. Irfan Rahman, Ph.D., professor of Environmental Medicine at the UR School of Medicine and Dentistry, led the research, which adds to a growing body of scientific data that points to dangers of e-cigarettes and vaping.

Please view the NBC news video about this article.

Read More: E-Cigarette Vapors, Flavorings, Trigger Lung Cell Stress

E-cigarette Vapors Can Damage Lung Cells

Monday, February 9, 2015

A new study by University of Rochester suggests that e-cigarettes are likely to be a toxic replacement for tobacco products.

Emissions from e-cigarette aerosols and flavourings damage lung cells by creating harmful free radicals and inflammation in lung tissue. Several leading medical groups, organizations and scientists are concerned about the lack of restrictions and regulations for e-cigarettes, said Irfan Rahman, lead author and professor of environmental medicine at University of Rochester Medical Center.

MSTP Announces 40th Anniversary Celebration!

Sunday, February 1, 2015

Edward Rubin

Edward M. Eddy Rubin

The Medical Scientist Training Program (MSTP) is excited to announce a celebration of the 40th anniversary of the MSTP NIH training grant on Friday, October 9, 2015.

The keynote speaker will be an MSTP alumni from the Class of 1980: Edward Rubin, MD, PhD, Director, DOE Joint Genome Institute.

Edward M. Eddy Rubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Division in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI's involvement in the Human Genome Project (HGP).

For more information and schedule of events for the day, please visit the MSTP 40th Anniversary page.

Alejandro Avilés Reyes Receives 2015 Arnold Bleiweis Travel Award

Friday, January 30, 2015

Alejandro Avilés Reyes, a graduate student in the Lemos Lab and lab of Jacqueline Abranches, Ph.D., has been selected for the 2015 Arnold Bleiweis Travel Award, to present his work entitled "Modification of Streptococcus mutans Cnm by a novel glycosylation pathway". Mr. Avilés Reyes will give his presentation during the upcoming General Session of the International Association for Dental Research Conference, to be held March 10-14, 2015 in Boston, MA, as part of the first Robert Marquis Mini-Symposium for Young Investigators in Microbiology and Immunology.

Alejandro is currently working on the characterization of Cnm, a collagen-binding protein produced by invasive Streptococcus mutans. The Lemos-Abranches lab focuses on characterization of the stress-response mechanisms of Gram-positive bacteria and their contribution to virulence and disease.

Congratulations to Fatima Rivera-Escalera

Sunday, January 25, 2015

Fatima Rivera-Escalera

Fatima Rivera-Escalera

Congrats to Fatima Rivera-Escalera, a fifth-year student in the Olschowka Lab who was awarded a Keystone Symposia Scholarship to attend the Keystone Symposium on Neuroinflammation in Diseases of the Central Nervous System in Taos, NM from January 25-30th, 2015.

UR Tests HIV Vaccine Pill

Tuesday, January 13, 2015

Researchers at the University of Rochester Medical Center are testing a new oral vaccine to prevent infection with HIV, the virus that causes AIDS. The vaccine is unique because it is given as a pill, unlike most HIV vaccines tested to date that have been given as shots

The study is funded and designed by Beth Israel Deaconess Medical Center (BIDMC), which received support for a Collaboration for AIDS Vaccine Discovery grant from the Bill & Melinda Gates Foundation. The URMC team and BIDMC are collaborating with the International AIDS Vaccine Initiative, which is helping to organize the study through its Vaccine Product Development Center to provide services to BIDMC grantees. This is one of the first studies to benefit from this partnership and URMC is the only center in the world testing this vaccine.

Read More: UR Tests HIV Vaccine Pill

NIH Neuro Start Up Challenge

Monday, January 12, 2015

Several neuroscience graduate students and clinicians from the University of Rochester are involved in the NIH Neuro Start Up Challenge and have developed their elevator pitch and executive summary as part of the public voting phase. We encourage the neuroscience community to visit their Showcase page and provide votes and constructive feedback on the discussion board this week. Public voting will run Monday, January 12th through Friday, January 16th.

Team: University of Rochester- 8&9.A (Inventions 8 and 9)

Company Name: VasoMark

About the Challenge: The Neuro Start Up Challenge, launched by the NIH in partnership with the CAI and HPN, is designed to bring brain-related, patented technologies from the NIH to market. Teams of medical, scientific and business experts compete in several phases to create a company and execute a business plan with the ultimate goal of launching their start-up.

Thank you for your support

New Study Probes Link Between HIV Drugs and Vascular Disease

Monday, January 5, 2015

A new $3.8 million grant will bring together clinical and bench researchers to better understand why individuals who receive anti-retroviral treatment for HIV are at greater risk for heart disease and stroke.

“The good news is that the drugs being used to fight HIV are increasing life expectancy to normal levels,” said University of Rochester neurologist Giovanni Schifitto, M.D., one of the co-leaders of the study. “However, one of the long-term complications is that these treatments, the infection itself, or a combination of the two are increasing risk for cardiovascular and cerebrovascular disease in this population.”

Read More: New Study Probes Link Between HIV Drugs and Vascular Disease

Researchers Find Protein That Could Control Weight Loss and Lead To Radical New Treatments For Obesity

Monday, December 29, 2014

Researchers have uncovered a protein they say controls how the body produces fat cells.

Called Thy1 it has a fundamental role in controlling whether a primitive cell decides to become a fat cell, the Daily Mail reports. Experts say it could be harnessed in obesity treatments.

We believe that weight gain is not necessarily just a result of eating more and exercising less, said lead author Richard Phipps of the University of Rochester. The Rochester team discovered that a protein, Thy1, has a fundamental role in controlling whether a primitive cell decides to become a fat cell, making Thy1 a possible therapeutic target, according to a study published online this month by the FASEB Journal.

Read More: Researchers Find Protein That Could Control Weight Loss and Lead To Radical New Treatments For Obesity

Decoding Fat Cells: Discovery May Explain Why We Gain Weight

Thursday, December 11, 2014

University of Rochester researchers believe they’re on track to solve the mystery of weight gain – and it has nothing to do with indulging in holiday eggnog.

hey discovered that a protein, Thy1, has a fundamental role in controlling whether a primitive cell decides to become a fat cell, making Thy1 a possible therapeutic target, according to a study published online this month by the FASEB Journal.

The research brings a new, biological angle to a problem that’s often viewed as behavioral, said lead author Richard P. Phipps, Ph.D. In fact, some diet pills consist of antidepressants or anti-addiction medications, and do not address what’s happening at the molecular level to promote fat cell accumulation.

Read More: Decoding Fat Cells: Discovery May Explain Why We Gain Weight

Biochemistry & Biophysics Secondary Faculty Featured in Rochester Review

Friday, December 5, 2014

We were pleased to see Gloria Culver, Ph.D., a secondary faculty member in the Department of Biochemistry & Biophysics, mentioned in the Rochester Review Magazine in an article titled Going After Harmful Bacteria:

One challenge in killing off harmful bacteria is that many of them develop resistance to antibiotics. Now researchers are targeting the formation of the protein-making machinery, or ribosomes, in those cells as a possible way to stop the bacteria. Gloria Culver, Professor of Biology, has, for the first time, isolated the middle steps in the process that creates the ribosomes.

Published in Nature Structural and Molecular Biology, Culver’s work—conducted with graduate student Neha Gupta—captures a piece of ribosomal RNA in one of the intermediate states of being pared down to fit with protein molecules.

Read More: Biochemistry & Biophysics Secondary Faculty Featured in Rochester Review

NGP Student Wins Grand Prize

Monday, November 24, 2014

Jennifer Stripay, NSC PH.D. Candidate

Jennifer Stripay, NSC PH.D. Candidate

Congratulations to NGP student Jennifer Stripay from the Mark Noble Lab, who has won the Grand Prize at the recent Wilmot Cancer Institute's 19th Annual Scientific Symposium.

Well done Jennifer!

Jonathan Macoskey Wins ASA Undergraduate Research Award

Thursday, November 6, 2014

Jonathan Macoskey (BME Class 2015) was the recipient of the 2014 Robert W. Young Award for Undergraduate Student Research in Acoustics from the Acoustical Society of America. The Robert W. Young Award will provide resources for Jonathan to complete his proposed research project focused on developing a high-frequency ultrasound technique to visualize and quantify material properties of engineered tissue constructs. Jonathan is an undergraduate research assistant working in Professor Diane Dalecki’s biomedical ultrasound laboratory, and his project contributes to a joint collaboration between Professor Dalecki and Professor Denise Hocking (Pharmacology and Physiology) dedicated to developing new ultrasound technologies for tissue engineering.

Department Welcomes New Faculty Member!

Wednesday, November 5, 2014

Photo of Xin Li, Ph.D.

Xin Li, Ph.D.

The Department of Biochemistry & Biophysics welcomes the arrival of Xin Li, Ph.D., who is a new Assistant Professor. Dr. Li studies the roles of PIWI-interacting RNAs (piRNAs) in the development of germ cells and to causes of infertility in humans and animals.

Dr. Li was previously a postdoctoral fellow with Philip Zamore at the University of Massachusetts Medical School. Please feel free to visit his personal and lab websites and view his CV.

URMC Researchers Receive $6.1M to Develop LungMAP

Thursday, October 30, 2014

researchers at University of Rochester Medical Center have launched a five-year effort to develop such a map. The project, called the Human Lung Molecular Atlas Program, or LungMAP, includes researchers from several other institutions and is supported by more than $20 million from the National Institutes of Health, $6.1 million of which was awarded to URMC.

With a detailed map of human lung development, health care providers will be able to more readily identify children who may be at risk for lung problems. For example, physicians know that infants who are born prematurely are more likely to develop emphysema or chronic obstructive pulmonary disease (COPD) in adulthood or later in life.

But we don’t always know which ones, or how severe their complications will be, said Gloria Pryhuber, M.D., professor of Pediatrics and Environmental Medicine and the study’s lead researcher at URMC. So that’s what this is really all about — we need to know more about how the lung is formed and heals normally, in order to encourage pre-term infants to develop more normally, and to help adult lungs to heal from diseases like pneumonia and emphysema.

Read More: URMC Researchers Receive $6.1M to Develop LungMAP

Doug Portman Elected to Succeed Krystel Huxlin as Next President of the Rochester Chapter of SfN

Monday, October 20, 2014

Douglas Portman will start his term as President of the Chapter January 1st, 2015.
Thank you for everyone who participated in the first presidential elections.
Thank you Krystel for serving as the first President and for reviving the Chapter.

Read More: Doug Portman Elected to Succeed Krystel Huxlin as Next President of the Rochester Chapter of SfN

'Red Effect' Sparks Interest in Female Monkeys

Monday, October 20, 2014

Ben Hayden, Ph.D.

Ben Hayden, Ph.D.

Recent studies have indicated that the color red tends to increase human attraction toward others, feelings of jealousy, and reaction times. New research by Ben Hayden, assistant professor of Brain and Cognitive Sciences, shows that female monkeys also respond to the color red, suggesting that biology, rather than culture, may play a fundamental role in red responses.

Read more about Red Effects...

Male Brains Wired to Ignore Food in Favour of Sex, Study Shows

Thursday, October 16, 2014

Douglas Portman, Ph.D.

Douglas Portman, Ph.D.

Males can suppress their hunger in order to focus on finding a mate, a new scientific study of a species of worm has shown.

The study, conducted by Douglas Portman at the University of Rochester Medical Center, points to how subtle changes in the brain's circuitry dictate differences in behaviour between males and females.

Researchers Receive $4 Million to Study Common and Costly Cause of Death: Sepsis

Thursday, October 9, 2014

A diverse team of immunologists, engineers and critical care clinicians at the University of Rochester Medical Center received $4 million from the National Institutes of Health to study sepsis, an over-the-top immune response to an infection that leads to organ failure and death in about one third of patients. Beyond administering antibiotics, fluids and other supportive measures, physicians have no specific treatment to stop the syndrome, which is the most expensive condition treated in U.S. hospitals, according to the Agency for Healthcare Research and Quality.

Read More: Researchers Receive $4 Million to Study Common and Costly Cause of Death: Sepsis

University Mourns the Sudden Loss of David Knill

Wednesday, October 8, 2014

David Knill

David Knill

David C. Knill, professor of brain and cognitive sciences, and associate director of the Center for Visual Science, passed away suddenly on October 6th at the age of 53.

The University has more information in their newscenter.


The Department of Brain & Cognitive Sciences has created a memorial website. From this site, you can post tributes or stories about Dave and invite friends and colleagues to post their own contributions.

Colleagues Pay Tribute to Phil Fay

Monday, October 6, 2014

Drs. Sriram Krishnaswamy of the Children’s Hospital of Philadelphia & University of Pennsylvania, and Peter Lollar of Emory University recently wrote a fitting tribute to our friend and colleague, Dr. Philip Fay, who passed away June 25, 2014 after a long battle with cancer. The two are researchers working in the same field as did Dr. Fay and published the tribute in Thrombosis and Haemostasis, a leading journal in the field. You can read the tribute here.

Professor Diane Dalecki and Professor Denise Hocking Receive NIH Grant

Friday, October 3, 2014

Diane Dalecki, Ph.D. (BME) and Denise C. Hocking, Ph.D. (Pharmacology & Physiology) have received a $2 million grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) for their project titled Ultrasound standing wave fields for vascular engineering. The goal of this 4-year project is to advance a novel ultrasound technology to fabricate complex, functional microvascular networks within three-dimensional engineered constructs.

Collaborators on this project are Maria Helguera, Ph.D. (Imaging Sciences, RIT), Ingrid Sarelius, Ph.D. (Pharmacology & Physiology) and Angela Glading, Ph.D. (Pharmacology & Physiology).

New, versatile vascularization strategies are needed to produce small-scale 3D tissue models and are critical for the fabrication of large-scale engineered tissues. The noninvasive capacity of ultrasound also enables innovative capabilities for fabricating microvessel networks within hydrogels injected within tissues. The successful completion of this project will provide new tools for tissue engineering and for a variety of clinical reconstructive and vascular surgery applications.

Making PhDs More Employable: New Education Initiative Paves the Way

Thursday, October 2, 2014

Preparing graduate students and post-doctoral trainees for jobs outside of academia is the goal of a new career-training program at the University of Rochester School of Medicine and Dentistry (SMD), supported by $1.8 million from the National Institutes of Health.

The award to Principal Investigator Stephen Dewhurst Ph.D.,Vice Dean for Research at the SMD, comes at a time when fewer opportunities for tenure-track faculty positions exist, and yet graduate students in biomedical sciences don’t always have the awareness, robust training, connections, or transferable skills needed to identify and succeed in a range of other careers.

Read More: Making PhDs More Employable: New Education Initiative Paves the Way

Ph.D. Students Receive Awards

Wednesday, September 24, 2014

Steven Baker won Best Poster Presentation Award for young scientists at the Fifth ESWI Influenza Conference in Riga, Latvia. Steven also received this year's Melville A. Hare Award for excellence in Graduate Research along with Julie Sahler.

Daniel Martinelli received this year's Melville A. Hare Award for excellence in Teaching.

Shannon Loelius was the recipient of J. Newell Stannard Graduate Student Scholarship Award presented to her at the School of Medicine and Dentistry Convocation.

Communities Considering Fracking Face Questions

Tuesday, September 16, 2014

A new report examines potential health-related issues facing communities in areas of the country suitable for natural gas extraction. The hope is that the study, which was coauthored by Katrina Korfmacher, director of the University's Environmental Health Sciences Center’s Community Outreach and Engagement Core, will shape future research around communities’ health questions and inform their decision-making.

Read More: Communities Considering Fracking Face Questions

Gerald Fink Provides Fitting Tribute to Fred Sherman at 2014 Yeast Genetics Meeting

Friday, September 12, 2014

On July 29th - August 3rd at the Yeast Genetics Meeting in Seattle, Washington, Gerald Fink provided a fitting tribute for Fred Sherman. Gerald Fink, Ph.D. is an American biologist, who was Director of the Whitehead Institute at MIT from 1990-2001. He graduated from Amherst College in 1962 and received a Ph.D. from Yale University in 1965, having elucidated the histidine pathway in the yeast, Saccharomyces cerevisiae.

The above video is a tribute to Gerry's friend and colleague, Fred Sherman, Ph.D. who he and many others have called 'The Founder of Yeast Molecular Biology'. Sherman was the American scientist who pioneered the use of the budding yeast Saccharomyces cerevisiae as a model for studying the genetics and molecular biology of eukaryotic cells.

Dr. Sherman passed away on September 16, 2013 after a long and distinguished career at the University of Rochester, in the department of Biochemistry and Biophysics, for which he was the former Chair (1982-1999). Among Fred's many awards, publications and accolades, none was more deserving than his induction into the National Academy of Sciences.

Read More: Gerald Fink Provides Fitting Tribute to Fred Sherman at 2014 Yeast Genetics Meeting

NGP Alumna and NGP Faculty Publication in J. Neuroscience

Friday, September 12, 2014

Alumna, Maria Diehl, and NGP faculty, Lizabeth Romanski, published a paper in August 2014 edition of the Journal of Neuroscience on Responses of Prefrontal Multisensory Neurons to Mismatching Faces and Vocalizations.Read More: NGP Alumna and NGP Faculty Publication in J. Neuroscience

Site Asks, What's the Future of Scientific Research?

Friday, September 12, 2014

Virologist Steve Dewhurst, vice dean for research at the School of Medicine and Dentistry, and associate vice president for health sciences research, shares his thoughts about the next 20 years of scientific discovery as a featured guest on a new website designed to prompt conversations on the future of federal support for scientific research in the United States. The site, Science 2034, is an initiative of the Science Coalition, a group that represents about 60 major research universities, including Rochester.Read More: Site Asks, What's the Future of Scientific Research?

Michele Saul Accepts Faculty Position at St. John Fisher

Monday, September 1, 2014

Michele Saul, PhD

Michele Saul, PhD

Dr. Michele Saul has accepted a position as Visiting Assistant Professor of Biology beginning this Fall. Michele was a popular instructor in ANA 258 here at the UR, where she worked with Dr. Martha Johnson-Gdowski. In addition to her new faculty position, she will continue part-time as a Postdoctoral student in our lab developing her studies on adolescent stress models in rodents.

Make sure to congratulate her!!

Deadly Viruses Are Put On Notice

Friday, August 29, 2014

I am a virologist, and have spent my professional career on HIV/AIDS research. In 2034, I expect to be working on something else – because AIDS will no longer be a problem.

Improved prevention efforts – including vaccines, microbicides and antiviral drugs – will have prevented all new infections with HIV. And those already infected with the virus will have been cured using powerful DNA-editing enzymes that can target and remove integrated proviral DNA from the chromosomes of infected cells.

Read More: Deadly Viruses Are Put On Notice

Researchers Receive $3.4 million to Study Experimental Drug Combination in HIV

Thursday, August 28, 2014

Researchers at the University of Rochester Medical Center and University of Nebraska Medical Center have received a $3.4 million grant from the National Institutes of Health to study an experimental drug combination that appears to rid white blood cells of HIV and keep the infection in check for long periods. While current HIV treatments involve pills that are taken daily, the experimental drugs’ long-lasting effects suggest the possibility of an HIV treatment that could be administered monthly, or perhaps a few times a year.

Read More: Researchers Receive $3.4 million to Study Experimental Drug Combination in HIV

Maquat Receives Prestigious NIH MERIT Award

Thursday, August 14, 2014

Lynne E. Maquat, Ph.D., the J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics, has received a MERIT award from the National Institutes of Health to continue her research in RNA biology.

Maquat is an internationally recognized expert in the field of RNA biology, in which she works to discover new cellular pathways and clues to the molecular basis of human disease. She is the Founding Director of the University’s Center for RNA Biology and in 2011 was elected to the National Academy of Sciences. She is one of three faculty members from SMD who have been appointed to the Academy and the only woman.

The MERIT award (the acronym stands for Method for Extending Research In Time) was established by NIH in 1986 to provide stable, long-term grant support to help top scientists pursue ambitious projects that require more time to develop -- with the idea that higher-risk research can lead to higher-impact findings. The award also lifts the burden of applying for new grants to fund their research. MERIT recipients receive five years of funding and are afforded a simplified renewal for a second five-year period, cutting out the complex reapplication process, as long as they meet certain criteria showing that their research has yielded results.

Scientists cannot apply for the award; they are nominated by the funding NIH institute. Less than five percent of NIH-funded investigators are selected.

Environmental Health Sciences Center Summer 2014 Newsletter Now Available

Monday, August 11, 2014

The University of Rochester Environmental Health Sciences Center Summer 2014 newsletter is now available.

Topics highlighted in this newsletter include:

Recent findings linking air pollution to Autism and Schizophrenia

Environmental Health Sciences Center Updates

  • Increasing Awareness of Chemicals in Personal Care Products
  • Research and Local Activism Address the Health Effects of Tobacco Smoke
  • March of Dimes Symposium: Early-life Exposures
  • Environmental Epigenomics Workshop
  • Enhancing Perinatal Environmental Health Education

Recognitions and Awards

New Center faculty and Toxicology graduate students

Please feel free to read the entire EHSC Newsletter.

Read More: Environmental Health Sciences Center Summer 2014 Newsletter Now Available

Elena Rustchenko Awarded R01 Grant

Wednesday, August 6, 2014

Photo of Elena Rustchenko, Ph.D.

Elena Rustchenko, Ph.D.

Research Associate Professor in the Department of Biochemistry and Biophysics, Elena Rustchenko, Ph.D. has been awarded an R01 grant from NIH, section Drug Discovery and Resistance, for her proposal Molecular mechanisms of caspofungin resistance in the pathogen Candida albicans. This is a three year grant totaling $675,000 and starting immediately.

The Rustchenko-Bulgac Lab has focused for many years on the chromasomal instability of the human fungal pathogen, Candida albicans. Congratulations Elena!

Brandon Walling Accepted into Howard Hughes Medical Institute Med-into-Grad Fellowship

Monday, August 4, 2014

Brandon Walling, an IMV graduate student in the Minsoo Kim Lab, has been accepted into the Howard Hughes Medical Institute Med-into-Grad Fellowship in Cardiovascular Science.

In 2005, HHMI launched the Med into Grad (MIG) Initiative to address the growing gap between basic biology and medicine. The Institute recognized that biomedical scientists could benefit from additional training to help them translate biological knowledge into effective medical treatments and diagnostics. MIG training includes the fundamentals of pathobiology, an introduction to how medicine is practiced, and a survey of the problems and challenges faced by medical practitioners.

HHMI has held two MIG Initiative competitions, awarding $26 million in grants to 25 graduate institutions. This funding has enabled them to initiate or enhance existing programs designed to help students obtain the skills necessary to partner with clinician-scientists in the application of emerging biological knowledge to medical practice. These programs train students to recognize and capitalize on translational opportunities that may arise from their research and, in some cases, may influence the direction of their future investigations.

2014 NGP Student Award Recipients

Friday, August 1, 2014

Congratulations to this year's Award Recipients

  • Grayson Sipe won a travel award from the Schmitt Program in Integrative Brain Research to attend the EMBL Conference, Microglia: Guardians of the Brain, held on 26-29 March 2014 in Heidelberg, Germany.
  • Heather Natola won a travel award from the Schmitt Program in Integrative Brain Research to attend the 45th annual American Society of Neurochemistry meeting in Long Beach, CA, March 8-12, 2014.
  • Adrianne Chesser received a travel award to attend the Alzheimer's Association International Conference in Copenhagen, Denmark on July 12-17, 2014 where she presented a poster.
  • Julianne Feola received a travel award from Graduate Women in Science to attend the Gordon Research Conference in Italy from June 29 - July 4,2014.
  • Ryan Dawes was awarded a Trainee Scholar Award from the Psychoneuroimmunology Research Society.

Department of Biochemistry and Biophysics Celebrates 15-Year Service Awards

Thursday, July 31, 2014

Sara Connelly and Shelley Burns

Sara Connelly (left) and Shelley Burns

We are pleased to celebrate Shelley Burns’ and Sara Connelly’s milestone anniversaries of working for the University of Rochester for 15 years in July 2014!

Shelley is an Administrator who wears many hats in the Department of Biochemistry and Biophysics. She is an expert Grants Administrator for the department and has an uncanny knowledge of NIH forms and regulations, and she keeps the faculty on time and compliant with all grant applications. She also coordinates recruitment and hiring of postdoctoral fellows, manages renovations, and is an authority on immigration and human resources rules and regulations.

Sara is a Technical Associate in the lab of Mark Dumont, Ph.D.. She is a highly accomplished scientist with knowledge and experience in areas ranging from yeast genetics to G protein coupled receptors to HIV envelope protein. She also performs vital roles in managing the Dumont lab (often referred to as the Connelly lab), providing instruction and guidance to students, and making the 3-7500 hallway a fun place to work. We are deeply appreciative of Shelley’s and Sara’s many years of service to our department!

NIH Awards Team of U of R Scientists $9 Million to Study Immune System in Action

Friday, July 18, 2014

Since the early days of Kodak, Xerox, and Bausch & Lomb, Rochester-area innovators have been making astounding discoveries in optics and imaging. Researchers at the University of Rochester are beginning a major study that will add to the region’s imaging expertise, while also advancing global understanding of how the body’s immune system works.

The National Institutes of Health (NIH) has awarded a five-year, $9 million Research Program Project Grant (PO1) to scientists in the School of Medicine and Dentistry to adapt and develop cutting-edge imaging techniques, allowing them to view the immune system while it is fighting infection and disease.

Read More: NIH Awards Team of U of R Scientists $9 Million to Study Immune System in Action

Marit Aure, PhD, Shares 1st Place in World-Wide Dental Research Contest

Wednesday, July 2, 2014

Postdoctoral associate Marit Aure, PhD, of the Center for Oral Biology in the Eastman Institute for Oral Health and member of Catherine Ovitt's lab, tied for first place at the highly-competitive International Association for Dental Research/Johnson & Johnson Hatton Awards Competition held recently in Cape Town, South Africa.

The judges determined that the science presented by Aure and Joo-young Park, affiliated with the National Cancer Institute/National Institutes of Health, was exemplary in both projects, surpassing 36 other researchers from around the world in their category. There was no second place winner.

Aure had qualified for the international competition by earning second place in the American Association of Dental Research/Johnson & Johnson Hatton Awards Competition, held in Charlotte, North Carolina in March. For the international round of the competition, all participants were required to condense the research talk into a four-slide, 10-minute presentation to be given in front of three judges.

Telling the whole story in 10 minutes and four slides was especially challenging, said Aure, who said the poker-faced judges had some very tough questions. My reaction to winning was a mix of surprise, excitement and joy! It feels really good to get positive feedback and exposure for the salivary research we’re doing.

Read More: Marit Aure, PhD, Shares 1st Place in World-Wide Dental Research Contest

William "Bill" O'Neill Retires from URMC

Monday, June 30, 2014

Bill O'Neill

William E. O'Neill, PhD

After more than 35 years of service to URMC, Bill has retired to devote more time to personal endeavors. He will remain deeply involved in the studies of his current students who appreciate his wealth of expertise.

Bill was Associate Professor in both the Department of Neurobiology & Anatomy at the Medical Center and for Brain/Cognitive Sciences on the River Campus. He will be deeply missed.

Make sure to congratulate him when you see him.

Department of Biochemistry and Biophysics Mourns the Loss of Dr. Philip Fay

Thursday, June 26, 2014

Dr. Philip Fay, Ph.D.

Dr. Philip Fay, Ph.D.

We are very saddened to relay the passing of our colleague and friend Phil Fay, Ph.D, Professor of Biochemistry and Biophysics. Phil passed away Wednesday June 25th after a long and courageous battle with cancer. His incredible strength of character through a most difficult time remains an inspiration to us all.

Calling hours will be 3-6 pm Sunday June 29 at Anthony Funeral Chapel, Brighton, 2305 Monroe Ave. Rochester, NY, US, 14618. His Funeral Mass will be 11 am Monday June 30 at St. Louis Church, 64 S Main St, Pittsford. Burial will follow at White Haven Cemetery, 210 Marsh Road Pittsford, with a reception to follow at the Country Club of Rochester. His Obituary can be found here.

Among numerous awards and significant accomplishments in an esteemed career, Phil and research assistant professor, Hironao Wakabayashi, M.D., Ph.D. were recently nominated for the 2014 RIPLA Distinguished Inventor of the Year Award given by the Rochester Intellectual Property Law Association (RIPLA). They were nominated for their work in the field of Factor VIII technology for treatment of hemophilia A patients.

On July 8th, 2014 the flags at the University of Rochester will be lowered in honor of Dr. Fay.

Wilmot Cancer Institute Scientists Receive $2M Award from NCI

Wednesday, June 25, 2014

The National Cancer Institute awarded more than $2 million to a team at the Wilmot Cancer Institute to continue their study of a gene network that controls cancer progression, with a focus on pancreatic cancer.

The five-year grant will fund a series of new scientific experiments involving a gene known as Plac8. In earlier work, Wilmot investigators showed that by inactivating Plac8 they could stop or slow pancreatic tumor growth in mice and significantly extend survival – making Plac8 an attractive target for drug development.

Principle investigator Hartmut Hucky Land, Ph.D., and co-investigator Aram Hezel, M.D., had been studying a wider system of genes and cellular events involved in cancer, when they discovered that Plac8 is a key driver in malignancies but is not essential to the function of normal tissue.

Read More: Wilmot Cancer Institute Scientists Receive $2M Award from NCI

Yelena Lerman Receives Medical Faculty Council Travel Award

Monday, June 23, 2014

Yelena Lerman is the recipient of the Medical Faculty Council Travel Award in Basic Science Research for Spring 2014. Yelena is in her sixth year of the Pharmacology PhD program under the mentorship of Dr. Minsoo Kim in the Department of Microbiology & Immunology. Yelena gave an oral and poster presentation of her work on “Exacerbated tissue homing of neutrophils during sepsis and TLR2-induced cytokine production are regulated by integrin a3b1” at the American Association of Immunologists (AAI) meeting in May 2014. Her work evaluated the surface expression kinetics of b1 and b3 integrin heterodimers on neutrophils during sepsis in both mice and humans. She showed that only integrin a3b1 is significantly upregulated during sepsis. Previous studies suggested a role for IL-10 as a regulator of the transition from mild sepsis to irreversible septic shock. Thus, sepsis progression could be modulated by altering IL-10 release and α3β1 upregulation.

Five Recognized for Research Excellence

Wednesday, June 18, 2014

Five Eastman Institute for Oral Health professionals were recognized at this month’s American Association for Dental Research’s local meeting.

Thirty researchers from the Rochester area participated in oral and poster presentations covering a wide range of basic and translational science topics, such as fluoride varnish effectiveness, use of therapy dogs in pediatric dental settings and the success of implants, among many others.

Dr. Catherine E. Ovitt, Ph.D., associate professor of Biomedical Genetics in EIOH's Center for Oral Biology, delivered the keynote address, Saving Saliva: Where do We Start? where Marit Aure, Ph.D. a Postdoctoral Associate in Dr. Ovitt's lab, won the William H. Bowen award for her poster presentation, Mechanisms of Acinar Cell Maintenance in the Adult Salivary Gland.

Read the full article.

Anisha Gundewar Receives 2014-15 Fulbright U.S. Student Grant Award

Thursday, June 12, 2014

Anisha Gundewar (B.S., Class of 2014) was awarded a 2014-15 Fulbright U.S. Student Grant. This fall, Anisha, will pursue an independent research project in India through the 2014-15 Fulbright U.S. Student Grant program.

Read More: Anisha Gundewar Receives 2014-15 Fulbright U.S. Student Grant Award

Paige Stepping Aside as Chair of Neurobiology & Anatomy

Thursday, June 12, 2014

Gary D. Paige, M.D., Ph.D., is stepping down after 16 years of service as chair of the Department of Neurobiology and Anatomy. M. Kerry O’Banion, M.D., Ph.D., will serve as interim chair effective July 1, 2014 while a national search for a permanent chair is conducted.

New Evidence Links Air Pollution to Autism, Schizophrenia

Friday, June 6, 2014

New research from the University of Rochester Medical Center describes how exposure to air pollution early in life produces harmful changes in the brains of mice, including an enlargement of part of the brain that is seen in humans who have autism and schizophrenia.

The new findings are consistent with several recent studies that have shown a link between air pollution and autism in children. Most notably, a 2013 study in JAMA Psychiatry reported that children who lived in areas with high levels of traffic-related air pollution during their first year of life were three times as likely to develop autism.

Our findings add to the growing body of evidence that air pollution may play a role in autism, as well as in other neurodevelopmental disorders, said Deborah Cory-Slechta, Ph.D., professor of Environmental Medicine at the University of Rochester and lead author of the study, published in the journal Environmental Health Perspectives.

Read More: New Evidence Links Air Pollution to Autism, Schizophrenia

Professor Mahin Maines Issued Two Patents

Friday, June 6, 2014

HeLa Cancer Cells

HeLa cancer cells dramatically increased in size
and morphology when human BVR is introduced.

Biochemistry and Biophysics Professor Mahin Maines has been issued two patents for identification and development of a novel cell proliferation and differentiation factor (US patent 6, 969,610), and for Identification of Biliverdin Reductase as a Leucine Zipper-Like DNA Binding/Transcription Factor. (US, Canada, Europe and Australia 2002360742).

Striking increase in BVR in a human
kidney tumor compared to normal kidney tissue.

Striking increase in BVR in a human
kidney tumor compared to normal kidney tissue.

The Maines laboratory has identified Biliverdin Reductase (BVR) in human cells as a novel regulator of cell proliferation and differentiation. Her research shows that HeLa cancer cells dramatically increase in size and morphology when human BVR levels are elevated within the cells by artificial means. Her lab also discovered a striking increase in BVR levels in a human kidney tumor compared to normal tissue (see images, above and below). They found that BVR regulates and/or modulates activity of protein kinases downstream of the insulin/IGF-1 signaling cascade, including MAPK/ERK1/2 signaling, and that BVR is essential for activation of the ERK1/2 kinases that control cell proliferation and growth. The work has implications for the treatment of cancer and has resulted in a patent issued in US, Canada, Europe and Australia for Identification of Biliverdin Reductase as a Leucine Zipper-Like DNA Binding/Transcription Factor. (US patent 6, 969,610).

Maines is a leading expert in BVR research and has uncovered many applications for this enzyme, including diabetes and a US patent was recently issued for this discovery. She also discovered two enzymes, HO-1 and HO-2 that are part of the same metabolic pathway as BVR. Her research in this area has opened up possible new therapeutic approaches to cardiovascular disease, diabetes and other disorders.

Brian Palmer Wins Two Awards at Toxicology Retreat

Wednesday, June 4, 2014

Brian Palmer with Award

Brian Palmer

Congratulations to Brian Palmer, a Toxicology graduate student in Lisa DeLouise's lab on winning two awards at the Annual Toxicology Retreat. Brian won the department 'Question" Award given to the student who asks the most insightful questions throughout the year at department seminars and also won the McGregor Award for best poster presentation by a first year graduate student.

Toxicology PhD Program Holds Annual Retreat

Thursday, May 29, 2014

Louis Guillette Jr., professor of obstetrics and gynecology at the Medical University of South Carolina, is the keynote speaker at the Department of Environmental Medicine Toxicology PhD Program annual retreat today. Guillette's talk, "Health or Disease: Environmental Contaminants, Epigenetics and the Developing Embryo" starts at 11 a.m. in the Class of '62 Auditorium (G-9425), Medical Center. Platform presentations will follow from 1:30 to 3 p.m. in the Ryan Case Method Room (1-9576) and a poster session will be held from 3 to 4:30 in Flaum Atrium.

NGP Alumna Links Playing Fantasy Sports with Neuroscience

Tuesday, May 27, 2014

Renee M. Miller, Ph.D. earned her undergraduate and graduate degrees in Neuroscience from the University of Rochester. Her current research is focused on sex differences in behavioral choices. She is a Lecturer in the Department of Brain and Cognitive Sciences where she teaches several neuroscience courses to undergraduates. Dr. Miller is an avid fantasy player, enjoying seasonal as well as daily fantasy NFL, NBA, and MLB. Recently, Dr. Miller published a book entitled Cognitive Bias in Fantasy Sports: Is Your Brain Sabotaging Your Team?

Richard Aslin Inducted into National Academy of Sciences

Tuesday, May 27, 2014

Richard Aslin, the William R. Kenan Professor in the Department of Brain and Cognitive Sciences and director of the Rochester Center for Brain Imaging, was inducted into the National Academy of Sciences at its 151st annual meeting in Washington, D.C.

Read More: Richard Aslin Inducted into National Academy of Sciences

Fay, Wakabayashi & Maines Featured in Democrat & Chronicle as Nominees for Inventor of the Year

Saturday, May 24, 2014

Among the other nominees for Inventor of the Year were B & &'s very own Drs. Philip Fay and Wakabayashi and Mahin Maines. Fay and Wakabayashi were nominated for the development of Factor VII proteins and Maines was nominated for discovering an unprecedented approach to mimic insulin action and increase glucose uptake for the treatment of diabetes.

Donald S. Rimai was named Distinguished Inventor of the Year at the ceremonies held at the Rochester Museum & Science Center. Rimai received 111 patents during his 34-year career at Eastman Kodak Co. The entire Democrat and Chronicle article is available here.

Pilot Awards Support Three Projects

Thursday, May 22, 2014

The Center for Integrative Bioinformatics and Experimental Mathematics in the Department of Biostatistics and Computational Biology has awarded two projects pilot awards: Identification of Interferon Stimulated Genes Regulating Viral Latency from Jian Zhu, assistant professor of microbiology and immunology, and Modeling Immune Response in 3-D Bioreactor Cultures of Human Secondary Immune Organ Cells from David Wu, professor of chemical engineering. One pilot project awarded last year, Quantitative Proteomic Analysis of Influenza-infected Mice from Sina Ghaemmaghami, assistant professor of biology, received a second-year renewal with supplementary funding.

Ghaemmaghami, a secondary faculty member in Biochemistry & amp; Biophysics, as well as the Center for RNA Biology general interest in understanding the mechanisms of protein expression, folding and degradation. We investigate how cells maintain a homeostatic balance between these processes, and how this homeostasis is effected by disease and aging. The projects in the lab draw on a number of disciplines including cell biology, biochemistry, systems biology and computational biology.

B & B Dept Graduate Student Wins Best Poster Award

Tuesday, May 20, 2014

Biochemistry and Biophysics graduate student Chinmay Surve has won the Best Poster Award at the recently concluded American Society of Pharmacology and Experimental Therapeutics society's, Upstate NY Pharmacological Society meeting in Buffalo, NY. Chinmay works in the laboratory of Dr. Alan Smrcka where he is looking at signaling molecules downstream of G protein coupled receptors (GPCRs) in neutrophils which play a role in neutrophil chemotaxis and how dynamism between these molecules regulate neutrophil chemotaxis.

Microbiology & Immunology Class of 2014 Commencement

Tuesday, May 20, 2014

Commencement was held for the Department of Microbiology & Immunology's Ph.D., Masters and Bachelors programs the weekend of May 17th. Congratulations to all of our graduates!

Ph.D. Degree Awarded: Sarah Amie, Waaqua Daddacha, Nan Deng , William Domm, Anthony Gaca, Joanne Lim, John Muchiri , Akeisha Sanders, Jacqueline Tung

Masters Degree Awarded: Anna Bird, Matthew Brewer, Anthony DiPiazza, Alison Gaylo, Kun Hyoe Rhoo, Letitia Jones, Dillon Schrock, Jason Sifkarovski, Madeline Sofia, Zhuo-Qian Zhang

BS/MS Program: Maksym Marek, Alexander Wei

Bachelors Program: Woori Bae, Robert Bortz, Natasha Chainani, Amanda Chan, Phillip Cohen, Hillary Figler, Anisha Gundewar, Zachariah Hale, Saad Ali Khan, Beom Soo Kim, Justin Kim, Soyeon Kim, Yo-El Kim, Kevin Koenders, Fang Liu, Clare C. Ma, Abhiniti Mittal, Bryan Myers, Ugochi Ndubuisi, Joo-Eun Park, Valerie Pietroluongo, Prishanya Pillai, Priyanka Pillai, Patrick Schupp, Vaidehi Shah, Meng-Ju Wu, Isabel Wylie

Tara Capece Receives Trainee Poster Award at 2014 AAI Meeting

Thursday, May 15, 2014

Graduate student, Tara Capece received the Trainee Poster Award at the 2014 AAI Immunology Conference for her work, Regulation of the integrin LFA-1 in T cell activation.

Tara is currently working on LFA-1 in T cell activation and migration in Dr. Minsoo Kim's lab. The Kim lab is focused on understanding how T cells and neutrophils home to and migrate within tissues.

Patrick Murphy Receives Trainee Abstract Award at 2014 AAI Meeting

Tuesday, May 13, 2014

Graduate student, Patrick Murphy received the Trainee Abstract Award at the 2014 AAI Immunology Conference for his work, Apoptotic cells suppress TNF production by tissue resident macrophages through a CD73-dependent mechanism.

Patrick is currently working on Purinergic regulation of macrophage inflammatory responses in Dr. Rusty Elliott's lab. The Elliott lab is focused on understanding the signaling pathways that regulate how phagocytes locate and engulf apoptotic cells and how this process impacts the immune system in normal and disease states.

Yelena Lerman Receives Trainee Abstract Award at 2014 AAI Meeting

Saturday, May 10, 2014

Graduate student, Yelena Lerman received the Trainee Abstract Award at the 2014 AAI Immunology Conference for her work, Exacerbated tissue homing of neutrophils during sepsis and TLR2-induced cytokine production are regulated by integrin a3b1.

Yelena currently works in Dr. Minsoo Kim's lab.

NGP Student Receives Trainee Award

Friday, May 9, 2014

Ryan Dawes, a third year NGP student in Dr. Ed Brown's lab was awarded a Trainee Award from the Psychoneuroimmunology Research Society.

NGP Student Wins Travel Award

Wednesday, May 7, 2014

Congratulations to NGP graduate student Julianne Feola who won a travel award from Graduate Women in Science to attend the Gordon Research Conference in Italy from June 29 – July 4, 2014.

Gene Discovery Links Cancer Cell ‘Recycling’ System to Potential New Therapy

Thursday, May 1, 2014

University of Rochester scientists have discovered a gene with a critical link to pancreatic cancer, and further investigation in mice shows that by blocking the gene’s most important function, researchers can slow the disease and extend survival.

Published online by Cell Reports, the finding offers a potential new route to intrude on a cancer that usually strikes quickly, has been stubbornly resistant to targeted therapies, and has a low survival rate. Most recent improvements in the treatment of pancreatic cancer, in fact, are the result of using different combinations of older chemotherapy drugs.

The research led by Hartmut Hucky Land, Ph.D., and Aram F. Hezel, M.D., of UR Medicine's James P. Wilmot Cancer Center, identifies a new target in the process of garbage recycling that occurs within the cancer cell called autophagy, which is critical to pancreatic cancer progression and growth.

Read More: Gene Discovery Links Cancer Cell ‘Recycling’ System to Potential New Therapy

David Williams Named to National Academy of Sciences

Tuesday, April 29, 2014

Vision scientist David Williams, the William G. Allyn Professor of Medical Optics, Dean for Research in Arts, Sciences & Engineering, and Director of the Center for Visual Science, has been named a member of the National Academy of Sciences in recognition of his distinguished and continuing achievements in original research.

Two NGP Students Win Schmitt Program on Integrative Brain Research Travel Awards

Thursday, April 24, 2014

Grayson Sipe, a 4thNGP student in Dr. Ania Majewska's lab and Heather Natola, a second-year student in Dr. Christoph Pröschel and Margot Mayer-Pröschel labs won the travel awards. Grayson used this award to attend the EMBL Conference: Microglia: Guardians of the Brain, March 26-29, 2014, held in Berlin, Germany, and Heather used it to travel to the 45th annual American Society of Neurochemistry meeting in Long Beach, CA, March 8-12, 2014

Dept Faculty Members Fay and Wakabayashi Nominated for the Distinguished Inventor of the Year

Wednesday, April 16, 2014

Dr. Philip Fay, Ph.D.

Hironao Wakabayashi, M.D., Ph.D.

Hironao Wakabayashi, M.D., Ph.D.

Biochemistry & Biophysics professor, Philip Fay, Ph.D. and research assistant professor, Hironao Wakabayashi, M.D., Ph.D. have been nominated for the 2014 RIPLA Distinguished Inventor of the Year Award given by the Rochester Intellectual Property Law Association (RIPLA). They were nominated for their work in the field of Factor VIII technology for treatment of hemophilia A patients.

Ongoing studies in the Fay lab include physical and biochemical analyses of factor VIII structure, inter-subunit interactions, and intermolecular interactions with other components of the clotting cascade. Dr. Fay's research program is aimed at gaining fundamental insights into the structure, activity and regulation of a protein central to hemostasis. This information will have specific implications for understanding hemophilia A and developing superior therapeutics for its treatment.

Drs. Fay and Wakabayashi's nomination and significant accomplishments will be recognized before the community at the Award Ceremony on Wednesday, May 14, 2014 from 6 to 9 pm at the Rochester Museum & Science Center (RMSC). The department would like to extend our congratulations to both!

URMC Researchers Win $3M Influenza Grant

Thursday, April 10, 2014

University of Rochester Medical Center researchers have won a $3 million grant to support influenza research. The award from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases is going to support ongoing research by New York Influenza Center of Excellence, a 7-year-old flu research center led by URMC scientists John Treanor M.D. and David Topham, Ph.D..

This award is an acknowledgement of the highly productive contributions our center has made to the overall understanding of how the immune response to flu is regulated, Treanor said.

Three BME Students Awarded Whitaker Scholarships

Wednesday, April 9, 2014

Biomedical Engineering students Echoe Bouta, Jason Inzana, and Amanda Chen have been awarded a 2014-2015 Whitaker International Program Scholarship grant. Echoe is a PhD candidate from Professor Edward Schwarz's Lab and will be pursuing her post-doctoral training at the Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. Jason is a PhD candidate in Professor Hani Awad's Lab and will be pursuing his post-doctoral research at the AO Research Institute in Davos, Switzerland. Amanda is currently a senior working in Danielle Benoit's Lab and will be pursuing a Masters degree in Chemical Engineering and Biotechnology at the University of Cambridge, working with Professor Nigel Slater.

Congratulations to all of you!

NGP Alumna Jill Weimer Receives her First R01

Friday, April 4, 2014

Study will explore intracellular trafficking

A grant from the National Institutes of Health (NIH) will provide Sanford Research’s Jill Weimer, PhD, with $1.75 million over five years to study intracellular trafficking in neurological disorders such as the rare pediatric Batten disease.

Read More: NGP Alumna Jill Weimer Receives her First R01

Allison Greminger Defends Thesis & Receives Prize for Best Graduate Student Publication at Toxicology Retreat

Thursday, April 3, 2014

Allison Greminger successfully defended her thesis entitled, Characterizing the Neurodevelopmental Sequalae in a Dual Insult Model of Gestational Iron Deficiency and Lead (Pb) Exposure. Her work was especially acknowledged at the Annual Retreat Dinner and Awards Ceremony on May 29th, where she received the prize for the best publication by a graduate student in the 2014 Environmental Medicine Toxicology Training Program.

Congratulations Allison!

Amanda Chen Receives Prestigious National Science Foundation Research Fellowship

Wednesday, April 2, 2014

Amanda Chen, a senior BME student and undergraduate research assistant in the Benoit Lab, received a prestigious National Science Foundation Research Fellowship, and first year BME graduate student Bentley Hunt, received an NSF Honorable Mention. The fellowship, which is part of a federally sponsored program, provides up to three years of graduate study support for students pursing doctoral or research-based master's degrees.

Department Alumnus Selected as part of a "Next Gen" Crystallographer Group for 2014 International Year of Crystallography

Thursday, March 27, 2014

Andrew T. Torelli (Ph.D. Biophysics 2008) was invited to attend the Opening Ceremony for the 2014 International Year of Crystallography (IYCr) held at UNESCO headquarters in Paris and served on a discussion panel as a representative of next-gen crystallographers. Many distinguished speakers, UN officials, international scientists, students and several hundred guests attended this historic event. The Secretary General of the United Nations, Ban Ki-moon, addressed the assembly by video, followed by Irina Bokova, Director-General of UNESCO, and the heads of multiple international scientific organizations. Keynote speakers included Jenny Glusker, who delivered a rich historical perspective of crystallography, and Brian Kobilka, who recounted his 2012 Nobel Prize work with Robert Lefkowitz involving G protein-coupled receptors. Other fascinating talks included efforts to expand X-ray crystallography in emerging nations, cutting edge technologies, the first extraterrestrial diffraction measurements used to interpret the mineralogy of Mars, and applications of crystallography and symmetry in the study of art. The Discussion Panel included eight selected, early-career crystallographers from around the world, and communicated critical issues facing the next generation of crystallographers to policy makers and sovereign delegations.

Announcing Faculty Promotions and Awards

Tuesday, March 25, 2014

The Department of Biochemistry and Biophysics is proud to announce the following well-deserved promotions, recently approved by the Board of Trustees and signed by President Seligman:

  • Alan Grossfield, promoted to Associate Professor of Biochemistry and Biophysics
  • Josh Munger, promoted to Associate Professor of Biochemistry and Biophysics
  • Joe Wedekind, promoted to Professor of Biochemistry and Biophysics
  • Yi-Tao Yu, promoted to Professor of Biochemistry and Biophysics

We were also very pleased to learn of the following awards in recognition of two very deserving Faculty:

  • Eric Phizicky, to receive the 2014 William H. Riker University Award for Graduate Teaching
  • Doug Turner (B&B secondary appointment) will receive the 2014 Doctoral Commencement Award for Lifetime Achievement in Graduate Education.

Both of these awards will be presented at the 2014 Doctoral Commencement on Saturday morning, May 17, 2014, at the Eastman Theater.

Please join us in congratulating these faculty! We are grateful for all of their hard work and service they offer our department, and for the contributions they make to the University. We look forward to hosting a party to celebrate their achievements sometime in the coming months.

Biochemistry & Biophysics Professor selected to Speak at Master's Commencement Ceremony

Monday, March 24, 2014

Professor Lynne Maquat, Ph.D., The J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics has been selected to be the speaker at the University of Rochester Master's Degree Ceremony. The ceremony is to be held at noon on May 17th, at the Eastman Theater.

Congratulations to Michael Hoffman for a successfully defending his Ph.D. Thesis!

Monday, March 24, 2014

Congratulations to Michael Hoffman for a successfully defending his Ph.D. Thesis! Michael worked in the Benoit Lab, and his project, Tissue Engineered Periosteum Approaches to Heal Bone Allograft Transplants, was supported by an NIH T32 training grant 'Training in Orthopaedic Research’.

Match Day 2014: Medical Scientist Training Program Matches 9 Students Across the Nation

Monday, March 24, 2014

By Kyle Koster, Public Relations Chair

Friday, March 21 was a bright day for the Medical Scientist Training Program. As the seconds ticked closer to noon, the buzz in Helen Wood Hall escalated, only to be replaced by a sudden silence as MSTP and medical students tore open envelopes revealing the programs to which they matched for residency training. This year was a particularly interesting and successful year for the MSTP. Students matched to top choices across the country; four MSTP students matched to West Coast programs and three to East Coast programs, with one student remaining in Rochester and another on to New Mexico. The choice of specialties was similarly broad, with four students matching into surgical specialties, two students into internal medicine, and three into the behavioral sciences.

This May, the program graduates nine students, all of whom matched on Friday. The MSTP congratulates its Class of 2014 with a graduation brunch at Mario's on April 27.

MSTP MATCH LIST 2014

Melisa Carrasco
Univ. of Maryland Medical Center, Baltimore, MD
Pediatrics-Preliminary/Child Neurology
Johns Hopkins Hospital, Baltimore, MD
Child Neurology
Joanna Olsen
Oregon Health & Science University, Portland, OR
Anesthesiology/Critical Care Medicine
Scott Peslak
Hospital of the U. of Pennsylvania, Philadelphia, PA
Internal Medicine–ABIM Research Track
Phillip Rappold
University of Rochester Medical Center, NY
Surgery-Preliminary/Urology
Danny Rogers
University of New Mexico, Albuquerque, NM
Pediatrics-Preliminary/Child Neurology
Mercedes Szpunar
University of California, San Diego Medical Center, CA
Psychiatry–Research Track
Edward Vuong
North Shore-LIJ Health System, Manhasset, NY
Internal Medicine
Ethan Winkler
University of California, San Francisco, CA
Neurological Surgery
Michael Wu
University of California, San Francisco, CA
Anesthesiology–Research Track

Duje Tadin is the 2014 winner of the Elsevier/Vision Sciences Society Young Investigator Award

Friday, March 21, 2014

Associate Professor, Department of Brain and Cognitive Sciences, Center for Visual Science, Department of Ophthalmology, University Of Rochester, NY, USA

Duje Tadin is the 2014 winner of the Elsevier/VSS Young Investigator Award.

Trained at Vanderbilt, Duje Tadin was awarded the PhD. in Psychology in 2004 under the supervision of Joe Lappin. After 3 years of post-doctoral work in Randolph Blake's lab, he took up a position at the University of Rochester, where he is currently an associate professor.

Duje's broad research goal is to elucidate neural mechanisms that lead to human visual experience. He seeks converging experimental evidence from a range of methods, including human psychophysics, computational modeling, transcranial magnetic stimulation (TMS), neuroimaging, research on special populations, collaborations on primate neurophysiology, and adaptive optics to control retinal images.

Marit Aure Places 2nd in the AADR/Johnson & Johnson Hatton Awards Competition.

Friday, March 21, 2014

Marit Aure, a Postdoctoral Associate from Catherine Ovitt's lab, has earned 2nd place in the AADR/Johnson & Johnson Hatton Awards Competition. She will now compete in the IADR Unilever Hatton Competition and Awards at the 92nd General Session & Exhibition of the IADR in Cape Town, South Africa, June 25-28, 2014.

Congratulations Marit!

Understanding Autism

Thursday, March 20, 2014

Loisa Bennetto, director of the developmental neuropsychology lab in the Department of Clinical and Social Sciences in Psychology, will present a talk on Understanding Autism at the next "Got Health?" event on Thursday, March 20. The free lecture will be held from 12:10 to 12:50 p.m. in the Rundel Auditorium at the Rochester Central Library, 115 South Ave. The talk is sponsored by the Center for Community Health in partnership with the Central Library.

James Roger Christensen, Ph.D. Emeritus Professor and Past Chair of Microbiology and Immunology Dies

Wednesday, March 19, 2014

The Department of Neurology is pleased and proud to announce that Dr. Laurie Seltzer, DO, Senior Instructor of Child Neurology and Epilepsy recently received an award from the editors of Pediatric Neurology for the best paper submitted in 2013 by a resident or fellow. The paper, Intraoperative EEG Predicts Postoperative Seizures in Infants with Congenital Heart Disease was published online on December 23rd 2013 and will also appear in a forthcoming print issue of the journal. The research was supported in part by a NIH Institutional Research and Academic Career Development Award (K12 NS 066098).

In this prospective, observational study, Dr. Seltzer and her co-investigators reviewed preoperative, intraoperative and postoperative EEG of 32 infants who underwent cardiac surgery. Among 17 of the children, the surgery involved deep hypothermic circulatory arrest (DHCA). Specific intraoperative EEG patterns seen in two patients undergoing prolonged DHCA were predictive of postoperative seizure within 2 days after surgery. The results suggest that the intraoperative EEG may be used not only as a tool for monitoring current status during surgery, but also as a predictive tool to determine risk for postoperative seizure in infants undergoing surgery with DHCA.

Dr. Seltzer’s accomplishment will be recognized at the 2014 Child Neurology Society Meeting in Columbus, OH.

Biochemistry & Biophysics Alum Patrick Brandt, To Give Seminar on Strategies for Choosing a Postdoc

Tuesday, March 18, 2014

Patrick Brandt

Patrick Brandt, who received his Ph.D. in Biochemistry working with Dr. Robert Bambara in the Department of Biochemistry & Biophysics, will present a seminar entitled Thinking Strategically About Your Postdoc Training on Friday March 21, 2014 in the Hellen Wood Hall Auditorium, 1W304. A reception will follow the talk, 4 pm - 5 pm. Patrick is also giving an additional talk on Friday, March 21: Using Microsoft Word to Format Your Dissertation in the Neuman Room (1-6823) from 9–10:30 AM.

Patrick is the Director of Science, Training and Diversity at the University of North Carolina School of Medicine and Dentistry. All graduate students are encouraged to attend! For more information about Patrick, visit the UNC Science, Training and Diversity page.

Read More: Biochemistry & Biophysics Alum Patrick Brandt, To Give Seminar on Strategies for Choosing a Postdoc

Crossing Elmwood: Using ultrasound for tissue engineering

Friday, March 14, 2014

Tissue engineering has resulted in some remarkable achievements: skin substitutes, cartilage replacements, artificial bladders, urethral segments, blood vessels, bronchial tubes and corneal tissue substitutes.

But these advances have been confined primarily to fairly simple organs comprised of thin structures, Denise Hocking, Associate Professor of Pharmacology and Physiology, noted at last week's presentation in the Crossing Elmwood seminar series.

Read More: Crossing Elmwood: Using ultrasound for tissue engineering

Researchers Awarded $3.5 Million in NYS Stem Cell Grants

Thursday, March 13, 2014

Six scientists from the University of Rochester School of Medicine and Dentistry have been recommended awards of more than $3.5 million by NYSTEM. The grants are for a wide range of research programs in the fields of neurological disorders, bone growth and repair, and cancer.

The diversity of these awards demonstrates that stem cell biology has become an essential research tool in a wide range of diseases, said Mark Taubman, M.D., dean of the School of Medicine and Dentistry. State investments in stem cell research – both for individual research programs and to create resources such as the Upstate Stem Cell cGMP Facility – has enabled many promising discoveries in this field to continue to move forward. In many instances, this research may have otherwise stalled for lack of funding support from other sources.

Among the 6 researchers are Biomedical Genetics' own Wei Hsu, Mark Noble, Margot Mayer-Pröschel and Jianwen Que.

Read More: Researchers Awarded $3.5 Million in NYS Stem Cell Grants

Free Webinar: 'The Future of RNA-based Therapies'

Wednesday, March 5, 2014

Faculty Perspectives, an online lecture series sponsored by the Office of Alumni Relations, will feature Lynne Maquat, director of the Center for RNA Biology and the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, on Thursday, March 6. Maquat will discuss the molecular basis of human diseases and new RNA-centric therapies to treat them. The free webinar starts at 1 p.m.

Grayson Sipe Awarded Individual Pre-doctoral Fellowship from NINDS

Wednesday, March 5, 2014

Grayson Sipe, 4th year Neuroscience Graduate Program student in Dr. Ania Majewska's lab was awarded NIH (NRSA) Individual Pre-doctoral Fellowship from NINDS. The title of his project is: Role of P2Y12 and Purinergic Signaling in Microglia-Mediated Synaptic Plasticity (2013-2016). Congrats Grayson!

Congratulations to Andrew Shubin for a Successful Qualifying Exam!

Sunday, March 2, 2014

Congratulations to Andrew Shubin for a Successful Qualifying Exam! Andrew is currently a graduate student in the Benoit Lab, and his current project is Developing hydrogels for the regeneration of salivary glands.

Air Pollution Exposure May Increase Risk of Autism, Schizophrenia

Tuesday, February 18, 2014

Air pollution exposure has long been suspected to increase the risk of both heart and lung diseases, but another important organ may also be at risk of injury from this contaminated air: the brain. Researchers at the American Association for the Advancement of Sciences (AAAS) annual meeting in Chicago recently detailed the impact that constant exposure to air pollution may have on the developing brain. According to the panel, a series of mouse models have suggested that constant inhalation of air pollution may lead to enlargement of the brain’s ventricles – a hallmark of neurodevelopmental disorders such as schizophrenia and autism.

According to the organizer of the panel, Dr. Deborah Cory-Slechta, air pollution is a cocktail of various metals and gases, often consisting of many different sized particles. The larger particles typically do not pose a risk to the body, as they are often coughed up and disposed, but the very small particles are the ones that health experts say pose the biggest health threat.

The component people worry about the most are the smallest particles – the ultrafine particles, Cory-Slechta, professor in the department of environmental medicine at the University of Rochester School of Medicine, told FoxNews.com. And the reason is because those go all the way down into the bottom of the lung. Once they get to the bottom of the lung, they can be absorbed into the blood stream.

Read More: Air Pollution Exposure May Increase Risk of Autism, Schizophrenia

Chinmay R. Surve Wins Travel Award to Attend the American Society Experimental Biology Meeting

Tuesday, February 18, 2014

Chinmay R. Surve, a graduate student in the Department of Biochemistry was recently awarded a Graduate Student Travel Award to attend the American Society for Pharmacology & Experimental Therapeutics section of the Experimental Biology Meeting in San Diego, CA (2014). Chinmay works in the laboratory of Dr. Alan Smrcka where he is looking at signaling molecules downstream of G protein coupled receptors (GPCRs) in neutrophils which play a role in neutrophil chemotaxis and how dynamism between these molecules regulate neutrophil chemotaxis.

Rahman Group's Study Featured on the February 2014 Cover of the Journal of Proteome Research

Friday, February 14, 2014

Cover of the Journal of Proteome Research

Exposure to cigarette smoke is known to cause changes in the chromatin -- the complex of DNA and proteins that make up a cell's nucleus. This can lead to chronic lung disease. UR researchers Irfan Rahman, Professor of Environmental Medicine and Pulmonary Diseases, and Alan Friedman, Assistant Professor of Environmental Medicine, are shedding light on the role of histones in this process. Histones are key proteins that pass along genetic information from parents to children, play a role in gene expression, and act as spools for DNA to wind around.

Their study, featured on the cover of the Journal of Proteome Research (February 2014), reports that cigarette smoke induces specific post translational modifications in histones H3 and H4, which could serve as biomarkers to help identify and predict chronic lung diseases (COPD and lung cancer) induced by cigarette smoke. Their data may also help in our understanding of the epigenetic changes that occur during the development of these diseases.

Read More: Rahman Group's Study Featured on the February 2014 Cover of the Journal of Proteome Research

Local Researchers Develop Possible Treatment for Parkinson's

Monday, February 10, 2014

Astrocyte Photo

Researchers in Rochester have developed a new cell therapy that could treat Parkinson’s disease, a neurological disorder which affects motor function. The study from the University of Rochester Medical Center suggests this new approach could not only halt progression of the disease, but also reverse its impact on the brain.

Now, researchers have found a way to use supporter cells known as astrocytes to spur wider recovery throughout the brain. So we can think of them as a work crew that delivers multiple tools at the same time, each of which can target a different cell population, says lead author Chris Proschel.

Proschel says they were careful to begin their treatment only after their lab mice had developed signs of Parkinson’s disease. He says this delay is important because it mimics the way therapies are actually used in humans, where damage has occurred and symptoms have presented before any treatment is carried out.

Read More: Local Researchers Develop Possible Treatment for Parkinson's

Finding Points to Possible New Parkinson’s Therapy

Tuesday, January 28, 2014

A new study shows that, when properly manipulated, a population of support cells found in the brain called astrocytes could provide a new and promising approach to treat Parkinson’s disease. These findings, which were made using an animal model of the disease, demonstrate that a single therapy could simultaneously repair the multiple types of neurological damage caused by Parkinson’s, providing an overall benefit that has not been achieved in other approaches.

One of the central challenges in Parkinson’s disease is that many different cell types are damaged, each of which is of potential importance, said Chris Proschel, Ph.D., an assistant professor of Biomedical Genetics at the University of Rochester Medical Center (URMC) and lead author of the study which appears today in the European journal EMBO Molecular Medicine. However, while we know that the collective loss of these cells contributes to the symptoms of the disease, much of the current research is focused on the recovery of only one cell type.

Read More: Finding Points to Possible New Parkinson’s Therapy

Tara Capece Awarded NIH/NIAID F31 Ruth L. Kirschstein Predoctoral Fellowship

Sunday, January 12, 2014

Tara Capece, MS/MPH was awarded an NIH/NIAID F31 Ruth L. Kirschstein Predoctoral Fellowship for the grant titled: Regulation of the integrin LFA-1 during T cell migration and activation. Tara, a fourth-year doctoral candidate in , Minsoo Kim's lab, was awarded a two and a half year fellowship from the National Institute of Allergy and Infectious Disease to investigate how the integrin LFA-1 is modulated by chemokine signals and T cell receptor signals to serve different functions, as the former induces cell migration while the later mediated stable cell-to-cell contact. Answering these questions will provide novel insight for vaccine and immunomodulatory drug design.

Biologist Sina Ghaemmaghami Honored with a National Science Foundation Early Career Award

Friday, January 10, 2014

Sina Ghaemmaghami, an assistant professor of biology and member of the Biology & Molecular Biology and Biophysics, Structural & Computational Biology graduate programs at the University of Rochester, has been recognized by the National Science Foundation (NSF) as a scientist who exemplifies the role of teacher-scholar. The NSF has named Ghaemmaghami a winner of its Faculty Early Career Development Award (CAREER).

The award includes a five-year grant totaling $950,000 to fund Ghaemmaghami's research into protein folding. Sina is already recognized as one of the brightest in his field," said John Jaenike, chair of the University's Department of Biology. His work on protein folding and proteomic turnover is of central importance to understanding basic cell physiology.

As an early-career scientist, this award will go a long way in helping me establish a viable long-term research program at the University, said Ghaemmaghami. I especially appreciate the special focus this award places on the integration of education, which will lead to research opportunities for more undergraduates.

Read More: Biologist Sina Ghaemmaghami Honored with a National Science Foundation Early Career Award

In Memoriam: Fred Sherman - The First Yeast Molecular Biologist

Tuesday, January 7, 2014

The journal Genetics has published an article in memory of Dr. Fred Sherman, who died September 16, 2013 at the age of 81 years after a long illness. A renowned molecular biologist, Fred obtained his Ph.D. with Robert Mortimer at the University of California, Berkeley, followed by postdoctoral training with Boris Ephrussi in France and Herschel Roman in Seattle. He spent his entire career as a Professor at the University of Rochester School of Medicine. Fred received many awards, including election to the National Academy of Sciences.

Dr. Irfan Rahman's Article About the "Grandmother" Clock Featured on Cover of FASEB Journal

Monday, January 6, 2014

Cover of FASEB Journal

The Clockmaker, c. 1735, color engraving, Engelbrecht, Martin (1684–1756). Engelbrecht, a noted print-seller and engraver, was best known for his miniature theater dioramas. Eight scenery-like cards are inserted into a peep-box, aligned one behind the other, creating a three-dimensional view. These popular home-theaters have been cited by photographers and cinematographers for their dramatic optical effects. Some even suggest that they are forerunners of cable television. Our grandmother clock, an 18th-century Rococo extravaganza of ormolu scrolls and miniature dragons, stands stage center against a backdrop of cedar trees. Her body consists of two timepieces: one resting on her bosomy mantel and the other, a longcase model resting on curlicued paws. In her right hand, she dangles a pendulum—perhaps a reference to Galileo's discovery. The theatrical image may also be a tribute to Engelbrecht's hometown of Augsburg, the chief supplier of highly ornamental clocks to all of Europe. In this issue, we learn how tobacco smoke disrupts the circadian rhythm of clock gene expression, increasing lung inflammation to produce emphysema in mice via sirtuin 1 (SIRT1)-dependent acetylation of the core clock gene, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1). Image courtesy of Bibliothèque des Arts décoratifs, Paris, France/Archives Charmet/Bridgeman Art Library; Ann Weissmann, fine arts editor.

Environmental Medicine professor, Irfan Rahman's current article has been featured on the cover of the Journal of The Federation of American Societies for Experimental Biology. The article, entitled Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway, deals with patients with obstructive lung diseases display abnormal circadian rhythms in lung function. The Rahman lab determined the mechanism whereby environmental tobacco/cigarette smoke (CS) modulates expression of the core clock gene BMAL1, through Sirtuin1 (SIRT1) deacetylase during lung inflammatory and injurious responses.

Want To Sleep Peacefully? Quit Smoking, Study

Friday, January 3, 2014

A University of Rochester study has found that smokers can have a good night's sleep just by giving up the habit. Researchers said that smoking leads to sleep deprivation, depression and anxiety, cognitive decline and mood disorders. Lack of sleep can result in lethargy, crankiness and bad temper.

This study has found a common pathway whereby cigarette smoke impacts both pulmonary and neurophysiological function, Dr. Irfan Rahman from the University of Rochester Medical Centre in New York said in a press release. We envisage that our findings will be the basis for future developments in the treatment of those patients who are suffering with tobacco smoke-mediated injuries and diseases.

NBA's Patricia White's Research Featured in Journal of Neuroscience

Friday, November 22, 2013

Cochlear Inner Hair Cell

Cochlear inner hair cell from an adult mouse, viewed as a three-dimensional reconstruction from a whole mount confocal stack. The inner hair cell is labeled with Myo7a (grey), ribbon synapses and hair cell nuclei are labeled with CtBP2 (red), and glutamate receptors are labeled with Gria2/3 (green). This technique was used to analyze the role of Foxo3 in the adult mouse cochlea. For more information see Gilels et al..


Assistant Professor of Neurobiology and Anatomy, Patricia White's most recent publication, Mutation of Foxo3 Causes Adult Onset Auditory Neuropathy and Alters Cochlear Synapse Architecture in Mice has been featured in the November edition of the Journal of Neuroscience. In addition, an image of a cochlear inner hair cell from the article was also selected as the cover for that journal.

Dr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010.

The White lab's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.

Read More: NBA's Patricia White's Research Featured in Journal of Neuroscience

Professor Laurel Carney Receives NIH-NIDCD Grant Renewal

Thursday, November 21, 2013

Professor Laurel Carney received a renewal for another five years for her NIH-NIDCD grant entitled Auditory Processing of Complex Sounds. The new emphasis for the next five years is to investigate neural coding of speech sounds, starting with vowels. This new direction is possible thanks to the collaboration with Professor Joyce McDonough from the Linguistics Department. This grant will support graduate students and a post-doc in BME, Linguistics, or related fields who are interested in speech coding in the brain.

Clinical Trial for Children with Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)

Friday, November 1, 2013

The University of Rochester Medical Center is currently recruiting subjects with JNCL for a clinical trial. This research study will focus on evaluating whether an investigational drug is safe and well tolerated in children with JNCL. Mycophenolate mofetil (also known as Cellcept) is a medication that suppresses the immune system. The study is 22 weeks long with a total of 8 in-person visits and 4 telephone contacts. Four visits require travel to University of Rochester Medical Center in Rochester, New York, and four visits are with your child’s local physician. Four contacts take place by telephone. Travel costs are covered by the study. Children enrolled in the study will take mycophenolate syrup twice a day, and will have blood drawn at each study visit to monitor safety.

More information on the trial can be found at ClinicalTrials.gov, Time Warner Cable News (Rochester, NY television affiliate) and the URMC Newsroom.

For further information, please contact Amy Vierhile at (585) 275-4762.

Read More: Clinical Trial for Children with Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)

Seeing in the Dark

Thursday, October 31, 2013

Find a space with total darkness and slowly move your hand from side to side in front of your face. What do you see? If the answer is a shadowy shape moving past, you are probably not imagining things. With the help of computerized eye trackers, a new cognitive science study finds that at least 50 percent of people can see the movement of their own hand even in the absence of all light.

Seeing in total darkness? According to the current understanding of natural vision, that just doesn't happen, says Duje Tadin, a professor of brain and cognitive sciences at the University of Rochester who led the investigation. But this research shows that our own movements transmit sensory signals that also can create real visual perceptions in the brain, even in the complete absence of optical input.

Read More: Seeing in the Dark

Bethany Winans Receives Young Investigator Award

Wednesday, October 23, 2013

Bethany Winans, a graduate student in the Lawrence lab received an American Association of Immunologists Young Investigator Award at the New York Immunology Conference in Bolton Landing, NY.

Congrats Bethany!

Dumont Wins Outstanding Course Director Award

Friday, October 11, 2013

Professor Mark Dumont, Ph.D., was recently presented the Outstanding Course Director Award for 2013. Mark has served as course director for Biochemistry IND 408, a core course in the graduate studies curriculum within the School of Medicine and Dentistry, for over 10 years. Previous to this service, Mark served as director of Biochemistry of Macromolecules, BCH 412, for 5 years. As noted by Professor Eric Phizicky, Ph.D., who lectures in IND 408, Mark has shown an uncanny ability, coupled with exceptional effort, to continually evolve the course to more up-to-date topics and to more sophisticated analysis of existing topics. Almost alone among course directors, he attends most lectures most years, allowing him to evolve a highly coherent course. Jeffrey Hayes, Ph.D., Professor and Chair of the Department of Biochemistry and Biophysics remarks that Mark's commitment to his students and efforts on their behalf has rightfully earned him the high opinion of both his colleagues and his students, and serves as an exemplary example for all those involved in teaching.

Established in 2013, this award is given to an Outstanding Graduate Course Director. The selection of the awardee is based on the course’s record of excellence, course-instructor survey evaluations and letters of recommendation from students enrolled in the course, and is presented by the Office of the Senior Associate Dean for Graduate Studies.

Paper of the Week, The Journal of Biological Chemistry

Friday, October 11, 2013

A journal article by Kamil J. Alzayady, Larry E. Wagner II, Rahul Chandrasekhar, Alina Monteagudo, Ronald Godiska, Gregory G. Tall, Suresh K. Joseph, and David I. Yule was selected as a Paper of the Week by The Journal of Biological Chemistry.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo AM, Godiska R, Tall GG, Joseph SK, and Yule DI. (2013) Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 288:29772-29784. (Paper of the Week)

Click here to view Kamil Alzayady's Author Profile.

Dr. Catherine Ovitt Accepted to the 2013 Mid-Career Women Faculty Professional Development Seminar

Tuesday, October 1, 2013

Dr. Catherine Ovitt has been accepted to the 2013 Mid-Career Women Faculty Professional Development Seminar to be held in Austin, TX in mid December. This three and a half-day seminar is primarily designed for women physicians and scientists holding medical school appointments at the Associate Professor level, and holding leadership positions within their discipline, department or institution. Seminar faculty members are chosen from various schools in the US and Canada for their demonstrated leadership abilities and offer knowledge, inspiration and valuable career advice to participants.

Students Receive Awards at Neuroscience Retreat

Tuesday, October 1, 2013

Anasuya Das, a former student in Dr. Krystel Huxlin's lab who defended her PhD thesis on July 18, 2013 was awarded the Doty Award for Excellence in Neuroscience Dissertation Research during 2013 Neuroscience Retreat.

Christina Cloninger, a 4th-year student in Dr. Gary Paige's lab, won second place in the John Bartlett Poster Session during 2013 Neuroscience Retreat, Rochester, NY.

Ryan Dawes, a third-year student in Dr. Ed Brown's lab, won a travel award from the Schmitt Program on Integrative Brain Research. Ryan plans to use this award to attend the American Association for Cancer Research (AACR) Advances in Breast Cancer Research Conference, which is being held in San Diego from October 3rd-6th, 2013.

Paige Lawrence Receives New R01 Grant from NIEHS

Monday, September 30, 2013

Dr. Paige Lawrence, professor in the departments of Environmental Medicine and Microbiology & Immunology has received a new R01 grant from the National Institutes for Environmental Health Sciences (NIEHS), entitled Transgenerational exposures as modifiers of host defense against infection.

Along with UR Collaborators Steve Gill, Ph.D. and Sally Thurston, Ph.D., this project will explore exposure to pollutants can cause transgenerational changes in biological processes and contribute to disease. Since very little of this research has focused on transgenerational epigenetic inheritance of changes in immune function, the proposed research will direct address this deficit, and will study how a family of common pollutants perturbs the development and function of the immune system across generations.

The objective of this project is to define key parameters involved in transgenerational inheritance of alterations in the function of the mammalian immune system that occur as a result of environmental exposure. The immune system is fundamentally important to public and individual health, and even slight modifications in its function can have a profoundly negative impact on health and disease. For instance, influenza virus infections pose significant global health threats, infecting over 1 billion people annually. Evidence points to prenatal and early life exposure to pollutants as overlooked contributors to poorer clinical outcomes following influenza and other respiratory infections.

Doctor Left Behind Story in Search of Ending

Wednesday, September 25, 2013

We live in the new age of Sherlock Holmes, what with movie and television versions of Sir Arthur Conan Doyle's moody but brilliant detective popping up like foggy nights in London town.

But it would seem that the late Dr. Robert J. Joynt, the former dean of the University of Rochester School of Medicine and Dentistry and an internationally recognized neurologist, was ahead of the Holmes revival. In addition to his formidable record of academic publication, Joynt, a Pittsford resident who died in April 2012 at age 86, had begun to turn out a series of short stories, five of which were published in Neurology, a medical journal.

Each mystery featured Holmes and his sidekick Dr. Watson confronted with a puzzler that had a solution grounded in neurology, the study of the nervous system. Joynt's sixth, and presumably last, Holmes mystery was found unfinished on his computer after his death.

Now the editors of Neurology are asking readers to complete the neurologist's story in 1,500 words or less. The winning entry will be published in Neurology. The author of the new material will share credit with Joynt. The uncompleted mystery and the contest rules can be found by going to Neurology.org and searching for The Case of the Locked House, the title of the incomplete story. (When you get to the story, click on Full Text.)

Mental Fog with Tamoxifen is Real; Scientists Find Possible Antidote

Tuesday, September 17, 2013

A team from the University of Rochester Medical Center has shown scientifically what many women report anecdotally: that the breast cancer drug tamoxifen is toxic to cells of the brain and central nervous system, producing mental fogginess similar to chemo brain.

However, in the Journal of Neuroscience, researchers also report they've discovered an existing drug compound that appears to counteract or rescue brain cells from the adverse effects of the breast cancer drug.

Corresponding author Mark Noble, Ph.D., professor of Biomedical Genetics and director of the UR Stem Cell and Regenerative Medicine Institute, said it's exciting to potentially be able to prevent a toxic reaction to one of the oldest and most widely used breast cancer medications on the market. Although tamoxifen is more easily tolerated compared to most cancer treatments, it nonetheless produces troubling side effects in a subset of the large number of people who take it.

Read More: Mental Fog with Tamoxifen is Real; Scientists Find Possible Antidote

Congratulations to Amy Van Hove for a Successful Qualifying Exam!

Thursday, September 12, 2013

Congratulations to Amy Van Hove for a Successful Qualifying Exam! Amy is currently a graduate student in the Benoit Lab, and her current project is Therapeutic Biomaterials for Wound Healing Applications (Supported by an HHMI Med-Into-Grad Fellowship).

Dirken Wins Convocation Award

Thursday, September 12, 2013

Dr. Robert T. Dirksen was selected as the 2013 recipient of the Excellence in Postdoctoral Mentoring Award. This award is presented to a postdoctoral mentor who shows dedication to postdoctoral trainees, as well as evidence of contributing significantly to their career development and professional advancement and was presented at the School of Medicine and Dentistry Convocation, September 12, 2013.

Neuroscience Retreat to Feature Nobel Laureate

Wednesday, September 4, 2013

The annual Neuroscience Retreat, sponsored by the Neuroscience Graduate Program and the University Committee for Interdisciplinary Studies, will be held from 8:30 a.m. to 4 p.m. Friday, Sept. 13, at the Memorial Art Gallery. The retreat will feature keynote speaker Martin Chalfie, University Professor at Columbia University and winner of the 2008 Nobel Prize in Chemistry; talks from current and former faculty and graduate students; and a poster session. The event is free and open to the University community but advance registration is required. To register or for more information, visit the retreat website.

Ethan Winkler Wins 2013 Vincent du Vigneaud Commencement Award

Wednesday, August 28, 2013

Ethan Winkler

The 2013 Vincent du Vigneaud commencement award for PhD research went to Ethan Winkler, an MD/PhD student in Dr. Zlokovic's lab. To date, Ethan has 12 publications, six of which he is first author or shares that position with Dr. R. Bell. These include publications in some of the very best journals like Nature and Nature Neuroscience. Congratulations, Ethan!

Tara Capece and Patrick Murphy Appointed to Immunology Training Grant

Thursday, August 15, 2013

CVBI students, Tara Capece (Minsoo Kim lab) and Patrick Murphy (Rusty Elliot lab), were appointed to a position on the Immunology Training Grant (T32 AI007285). There was considerable competition with many strong candidates. The center would like to congratulate both on such a distinct honor.

NGP Student, Helen Wei, Awarded the HHMI Med-Into-Grad Fellowship

Saturday, August 10, 2013

Helen Wei, Neuroscience and MD/PhD student in Dr. Maiken Nedergaard's lab was awarded the HHMI Med-Into-Grad Fellowship (September 2013-August 2014). Helen's current project is astrocytes in neurodegenerative disease. Congrats Helen!

NGP Student, Jennifer Stripay, Awarded Pre-Doctoral Fellowship from NIH

Saturday, August 10, 2013

Jennifer Stripay, 3rd year Neuroscience Graduate student in Dr. Mark Noble's lab was awarded F31 NIH (NRSA) Individual Pre-doctoral Fellowship for her project entitled: Identifying c-Cbl as a critical point of intervention in glioblastoma multiforme (September 2013-August 2016). Congrats Jennifer!

URMC Biochemistry Professor Receives 2014 ASBMB William C. Rose Award

Friday, August 9, 2013

Lynne Maquat, Ph.D., the J. Lowell Orbison Endowed Chair & Professor, Biochemistry & Biophysics, Director of the University of Rochester Center for RNA Biology, and Chair of the University of Rochester Graduate Women in Science, has been selected to receive The American Society for Biochemistry and Molecular Biology (ASBMB) 2014 William C. Rose Award. The William C. Rose Award recognizes outstanding contributions to biochemical and molecular biological research and a demonstrated commitment to the training of young scientists, as epitomized by the late Dr. Rose. A part of the Award includes transportation to the 2014 ASBMB Annual Meeting to present a lecture, April 26-30, 2014 in San Diego. For more on Dr. Maquat and her research program please visit the Maquat Lab.

Read More: URMC Biochemistry Professor Receives 2014 ASBMB William C. Rose Award

NGP Students Adam Pallus, Rebecca Lowery, and Brianna Sleezer Awarded a Competitive Graduate Fellowship From Center for Visual Science

Wednesday, August 7, 2013

Adam Pallus, NGP graduate student in Dr. Ed Freedman's lab, Rebecca Lowery, NGP student in Dr. Ania Majewska's lab, and NGP student, Brianna Sleezer in Dr. Ben Hayden's lab were awarded a competitive graduate fellowship from the University of Rochester Center for Visual Science from 7/1/13 to 12/31/13. CVS offers competitive graduate fellowships for graduate students working in the lab of a CVS faculty member. Applications are made by a student's advisor to the vision training committee in CVS. Fellows receive full stipend support as well as funds to cover one academic conference per year.

NGP Students Christina Cloninger and Colin Lockwood Awarded Graduate Fellowship

Wednesday, August 7, 2013

Christina Cloninger and Colin Lockwood have been awarded a Hearing, Balance, and Spatial Orientation Training Grant by the National Institutes of Health. The Hearing, Balance, and Spatial Orientation Training Grant (T32) is funded by the NIH National Institute on Deafness and Other Communication Disorders. The grant involves the collaborative efforts of the Departments of Otolaryngology, Biomedical Engineering, and Neurobiology & Anatomy. The grant supports PhD students, MD-PhD students, Post-doctoral fellows and Medical Residents in BME, Neuroscience, and Otolaryngology who are involved in research related to the auditory and vestibular systems. This Training Grant is an important resource for the University of Rochester's Center for Navigation and Communication Sciences, which provides technical and administrative support for 25 faculty members who are conducting research in this area. The grant provides financial support for several trainees each year. In association with the Training Grant, a graduate-level course entitled Hearing and Balance: Structure, Function and Disease is offered.

NGP Students Matthew Cavanaugh, Michael Chen, Heather Natola, Felix Ramos-Busot, Rebecca Rausch, Aleta Steevens Awarded Graduate Fellowships

Wednesday, August 7, 2013

Matthew Cavanaugh, Michael Chen, Heather Natola, Felix Ramos-Busot, Rebecca Rausch, and Aleta Steevens have been awarded a competitive graduate fellowship, the Neuroscience Training Grant. This grant is funded by the National Institute of Health's National Institute of Neurological Disorders and Stroke. This prestigious appointment provides stipend, tuition support, travel funds as well as funds to cover trainee related expenses. Students are appointed to the NSC Training Grant by the NGP committee.

Faculty to Be Featured on Radio Show

Monday, August 5, 2013

Several University faculty members are scheduled to be featured this week on WXXI's 1370 Connection. Benjamin Hayden, assistant professor of brain and cognitive sciences, will be the guest at noon today. He'll talk about neuroeconomics—the intersection of neuroscience and financial matters (e.g. gambling, investing in the stock market). At 1 p.m., the guests will be James McGrath, associate professor of biomedical engineering, and Gregory Gdowski, executive director of the Center for Medical Technology Innovation. They'll discuss the process of converting biomedical research into commercially viable devices. Tomorrow at noon, Lynda Powell, professor of political science, will be on the program to talk about the effects of campaign contributions on the political process.

Dr. Mahin Maines Granted Patent

Friday, August 2, 2013

On June 4, 2013 Dr. Mahin Maines' patent application #8,455,427: Methods of Modifying Insulin Signaling Using Biliverdin Reductase was granted by the US Patent Trademark Office. The application of the technology is treatment of type 2 diabetes. The patent was issued for therapeutic use of a 7 residue peptide that activates insulin receptor kinase (IRK) and increases glucose uptake more effectively than insulin or IGF-1. The peptide is derived from biliverdin reductase, which itself is a kinase/kinase, a scaffold protein and intracellular transporter in the insulin/IGF-1/PI3-K/MAPK pathways. Additional patent applications for use of the reductase in regulation of the noted pathways are pending.

Study: No Link Between Mercury Exposure and Autism-like Behaviors

Tuesday, July 23, 2013

Since the mid-1980s, the Seychelles Child Development Study (SCDS) has studied potential health effects of methylmercury (MeHg) in Seychelles islanders. Most recently, SCDS director Dr. Edwin van Wijngaarden studied whether there might be a link between a mother’s MeHg level during labor and autism-like behaviors in her child. As reported in this news release, Dr. van Wijngaarden and his colleagues found no association between fetal exposure to MeHg and autism-like symptoms in children. Read more...Read More: Study: No Link Between Mercury Exposure and Autism-like Behaviors

Laura Yunes-Medina Receives Ruth L. Kirschstein National Research Service Award

Friday, July 19, 2013

Congratulations and best wishes to Laura Yunes-Medina for being awarded the Ruth L. Kirschstein National Research Service Award for Individual Predoctoral Fellowships! This grant will support her research work on defining CHOP-10 dependent adaptive ER stress pathways in neurons.

Professor's Company Produces Video

Friday, July 19, 2013

Oyagen Inc, a biotech company founded and directed by Harold C. Smith, Ph.D., Professor, Department of Biochemistry and Biophysics, and the Center for RNA biology has produced a video describing how the AIDS virus reproduces and how novel drugs being developed by the company to enable naturally occurring host defense factors to block the virus. The video was produced in conjunction with a recently graduated RIT student Tang Tao.

Read More: Professor's Company Produces Video

CVBI Postdoctoral Fellow Receives Vaccine Fellowship Award

Tuesday, July 2, 2013

Milan Popovic, a post-doctoral fellow in Minsoo Kim's Lab, was awarded the 2013 Rochester Vaccine Fellowship award. Selection for the fellowship was a unanimous decision by three independent reviewers who praised Milan for his outstanding achievement in vaccine-related research.

Mosmann Awarded Novartis Prize for Basic Immunology

Monday, July 1, 2013

Tim R. Mosmann, Ph.D., Director of the David H. Smith Center for Vaccine Biology and Immunology at the University of Rochester Medical Center, was awarded the 2013 Novartis Prize for Basic Immunology. He shares the prize, which is awarded every three years for breakthrough contributions to the fields of basic and clinical immunology, with Robert L. Coffman, Ph.D., Vice President and Chief Scientific Officer at Dynavax.

The prize was awarded for Mosmann and Coffman’s research on how the body responds to different invaders, for example, bacteria versus parasitic worms. In the early 1980’s, they zeroed in on a group of white blood cells called helper T cells or TH cells, which communicate with other cells to activate the immune system and wipe out intruders. They discovered that TH cells fall into two distinct groups: TH1 cells, designed to eliminate bacteria and viruses; and TH2 cells, which are more effective against extracellular organisms, like worms and other parasites.

When Tim started this research, scientists thought that helper T cells could be divided into at least two subgroups, but no one had been able to prove this, said Stephen Dewhurst, Ph.D., chair of the Department of Microbiology and Immunology at the Medical Center. Tim elegantly showed that these cells could be divided into two subsets that produced different secreted proteins (cytokines) and that had different functions – a finding that profoundly changed the way people think about the immune system.

Read More: Mosmann Awarded Novartis Prize for Basic Immunology

Ovitt Article Featured on NIDCR Website

Thursday, June 27, 2013

Drs. Catherine Ovitt & Szilvia Arany's article, Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivojournal Molecular Therapy, has been featured on NIDCR website. The results of the study suggest that optimization of in vivo siRNA-mediated silencing for clinical application could be an effective means of protecting salivary glands in the radiation treatment of head and neck cancer. They also pointed out that the approach has significant advantages over alternative methods, as it is limited to the salivary glands, does not involve viruses, and the block in Pkcδ protein expression is only temporary.

@ISSCR 2013

Wednesday, June 19, 2013

Above is Part 3 of ISSCR's video blogs from the 2013 ISSCR annual meeting. This video introduces the fascinating research in cell-based CNS repair done by Dr. Christoph Pröschel.

Dr. Pröschel’s most recent work has focused on using human glial progenitor cells to repair damage to the CNS caused by spinal cord injury. In a 2011 study published in PLoS One, Dr. Pröschel and colleagues describe how human glial precursors were able to restore motor function to spinal cord-injured rats. In our interview, Dr. Pröschel explains the difference between replacement and repair in cell-based regenerative medicine, a theme that fellow spinal cord injury researcher Dr. Aileen Anderson of UC Irvine also frequently touches on. In our video, Dr. Pröschel also has some remarks about direct lineage reprogramming.

Department Faculty Awarded 2013 Provost's Multidisciplinary Award

Friday, June 14, 2013

The Provost's Multidisciplinary Award provides pilot funding for especially exciting scholarly research with a high probability of future support from external sources of funding. The Award is designed to foster collaboration between departments and across schools at the University of Rochester. Five diverse research projects at the University were selected as recipients of the sixth annual Provost's Multidisciplinary Awards. The initiative provides $250,000 each year to support faculty research that crosses disciplines.

Read More: Department Faculty Awarded 2013 Provost's Multidisciplinary Award

Huntington's Brain Cells Regenerated, in Mice

Thursday, June 6, 2013

Huntington's disease, like other neurodegenerative diseases such as Parkinson's, is characterized by the loss of a particular type of brain cell. This cell type has been regenerated in a mouse model of the disease, in a study led by University of Rochester Medical Center scientists.

Mice whose received this brain regeneration treatment lived far longer than untreated mice. The study was published online Thursday in Cell Stem Cell.

We believe that our data suggest the feasibility of this process as a viable therapeutic strategy for Huntington's disease, said senior study author Steve Goldman, co-director of Rochester's Center for Translational Neuromedicine, in a press release.

Read More: Huntington's Brain Cells Regenerated, in Mice

Potential New Way to Suppress Tumor Growth Discovered

Monday, June 3, 2013

Researchers at the University of California, San Diego School of Medicine, with colleagues at the University of Rochester Medical Center, have identified a new mechanism that appears to suppress tumor growth, opening the possibility of developing a new class of anti-cancer drugs.

Writing in this week's online Early Edition of the Proceedings of the National Academy of Sciences, Willis X. Li, PhD, a professor in the Department of Medicine at UC San Diego, reports that a particular form of a signaling protein called STAT5A stabilizes the formation of heterochromatin (a form of chromosomal DNA), which in turn suppresses the ability of cancer cells to issue instructions to multiply and grow.

Co-authors are Xiaoyu Hu, Amy Tsurumi and Hartmut Land, Department of Biomedical Genetics, University of Rochester Medical Center; Pranabananda Dutta, Jinghong Li and Jingtong Wang, Department of Medicine, UCSD.

Read More: Potential New Way to Suppress Tumor Growth Discovered

Biochemistry & Biophysics Students Win Fellowships

Friday, May 24, 2013

Graduate students Nick Leioatts and Will McDougall were recently awarded an Elon Huntington Hooker Fellowship for the 2013-2014 academic year. The doctoral students were selected for their achievements in research from among graduate student applicants campus-wide. Nick's research focuses on using computational methods to understand ligand-induced structural changes in G protein coupled receptors (GPCRs), and is carried out in the laboratory of Alan Grossfield. Will's research focuses on the role of the HIV host-defense factor APOBEC3G and its inactivation by RNA binding, which may provide novel drugable targets for HIV treatment and prevention. His research is carried out in the laboratory of Harold Smith. Congratulations Nick and Will!

Motion Quotient

Thursday, May 23, 2013

A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose brains are better at automatically suppressing background motion perform better on standard measures of intelligence.

The test is the first purely sensory assessment to be strongly correlated with IQ and may provide a non-verbal and culturally unbiased tool for scientists seeking to understand neural processes associated with general intelligence.

Because intelligence is such a broad construct, you can't really track it back to one part of the brain, says Duje Tadin, a senior author on the study and an assistant professor of brain and cognitive sciences at the University of Rochester. But since this task is so simple and so closely linked to IQ, it may give us clues about what makes a brain more efficient, and, consequently, more intelligent.

Read More: Motion Quotient

New RNA Structure - the Wedekind Lab has it Covered!

Wednesday, May 22, 2013

Crystal structure of the preQ1-II riboswitch

Crystal structure of the preQ1-II riboswitch.

Department of Biochemistry and Biophysics Associate Professor Joseph Wedekind and members of his research group (Joseph Liberman, Mohammad Salim and Jolanta Krucinska) published a paper in the June 2013 issue of Nature Chemical Biology. The work describes the structure of an RNA molecule called the preQ1 class II riboswitch (featured on the journal's cover) that functions as a gene regulatory element for bacteria within the Firmicutes phylum, including human pathogens such as Streptococcus pneumoniae. The RNA structure is bound to the small molecule preQ1, which is the last soluble metabolite in the biosynthetic pathway that produces queuosine, a hypermodified base at the wobble position of certain tRNAs that promotes accurate genetic decoding. Because preQ1 is unique to the bacterial metabolome, the class II preQ1 riboswitch has potential as an antibacterial drug target.

The research was performed primarily at the University of Rochester and made extensive use of the Structural Biology and Biophysics Facility. The work also required the Stanford Synchrotron Radiation Lightsource (Menlo Park, CA), as well as Cornell High Energy Synchrotron Source (Ithaca, NY) where crystals were subjected to X-ray diffraction analyses. The work in Wedekind' lab was funded by the National Institutes of Health/ National Institute for General Medical Sciences (NIH/NIGMS).

The preQ1-II riboswitch structure reveals the chemical details of preQ1 binding in a pocket formed at the junction of three RNA helices. Complementary work from Wedekind's lab showed that preQ1 promotes a more compact shape that leads to blocking of a signal that is necessary for protein synthesis, which leads to lower levels of preQ1 in the cell. Of special note was the lab's observation that the mechanism of action used by the preQ1-II RNA riboswitch is entirely different than that used by the class I preQ1 riboswitch, whose structure and mode of preQ1 binding were reported previously by Wedekind's lab. Overall the results expand the known repertoire of metabolite-binding modes used by regulatory RNAs.

Department of Biochemistry & Biophysics Holds Annual Awards Ceremony

Friday, May 17, 2013

The Department of Biochemistry & Biophysics held its annual Awards Ceremony on Friday, May 17, 2013. Congratulations to our 2013 Graduates:

Ph.D. Program in Biochemistry

  • Jennifer DeAngelis
  • Kimberly Dean
  • Rozzy Finn
  • Jason Gloor
  • Chenguang Gong
  • Athena Kantartzis
  • Geoffrey Lippa
  • Jessica McArdle
  • Adam Miller
  • Sharon Pepenella
  • Karyn Schmidt
  • Wen Shen
  • Cody Spencer
  • Guowei Wu

Ph.D. Program in Biophysics

  • Prahnesh Akshayalingam Venkataraman
  • Paul Black
  • Zhenjiang Xu

Our department was particularly honored this year to receive the University of Rochester's prestigious Wallace O. Fenn Award named after the first Chairman of the Department of Physiology. This award is given annually to a graduating student from any program within the Medical Center judged to have completed especially meritorious Ph.D. thesis research. This year, the award was given to two recipients for their thesis originality, creative thinking and excellence in research and both recipients were students from the Department of Biochemistry & Biophysics! Congratulations to Paul Black and Chenguang Gong! For a complete list of all awards, please see the Awards Ceremony Program. Photos of the event can be viewed on the B&B event photos page.

W. Spencer Klubben Wins Walt and Bobbi Makous Prize

Friday, May 17, 2013

The second recipient of the Walt and Bobbi Makous Prize has been awarded to: W. Spencer Klubben, a Biomedical Engineering senior working in Ania Majewska's laboratory. As a biomedical engineer, Spencer concentrated in medical optics and developed a strong interest in visual perception and development. Spencer's work has primarily focused on quantifying microglia's effect on neuroplasticity within the visual cortex and visual system. Most experimental methods have been focused around the utilization of optical imaging to analyze neuronal activity within mouse cortex. Experiments were conducted on mice with a varying dosage of CX3CR1, a single allele genetic fractalkine receptor responsible for the mobility of microglia. Spencer will receive the Makous Prize at a College-wide award ceremony on Saturday, May 19.

The Walt and Bobbi Makous Prize was established this year by the Center for Visual Science, a research program of more than 30 faculty at the University dedicated to understanding how the human eye and brain allow us to see. The prize is named for Walt Makous, who was Director of the Center for Visual Science at the University of Rochester throughout the 1980s, and his wife Bobbi. The prize honors the graduating senior who has made the most outstanding contribution to vision research at Rochester.

Kids With Autism Quick To Detect Motion

Friday, May 10, 2013

Children with autism see simple movements twice as fast as other children their age, a new study finds. Researchers at Vanderbilt University and the University of Rochester were looking to test a common theory about autism which holds that overwhelming sensory stimulation inhibits other brain functions. The researchers figured they could check that by studying how kids with autism process moving images.

One can think of autism as a brain impairment, but another way to view autism is as a condition where the balance between different brain processes is impaired, says Duje Tadin, a co-author of the study out this week in the Journal of Neuroscience. That imbalance could lead to functional impairments, and it often does, but it can also result in enhancements.

Read More: Kids With Autism Quick To Detect Motion

Autistic Children See Movement Twice as Quickly as Those Without Condition

Thursday, May 9, 2013

Children with autism see simple movement twice as quickly as other children their age, according to a new study. Scientists think this hypersensitivity to motion may provide clues to what causes the disorder. The findings may explain why some people suffering with autism are sensitive to bright lights and loud noises.

We think of autism as a social disorder because children with this condition often struggle with social interactions, but what we sometimes neglect is that almost everything we know about the world comes from our senses. Abnormalities in how a person sees or hears can have a profound effect on social communication, says Duje Tadin, one of the lead authors on the study and an assistant professor of brain and cognitive sciences at the University of Rochester.

Although previous studies have found that people with autism possess enhanced visual abilities with still images, this is the first research to discover a heightened awareness of motion. The findings were reported in the Journal of Neuroscience by Tadin, co-lead author Jennifer Foss-Feig, a postdoctoral fellow at the Child Study Center at Yale University, and colleagues at Vanderbilt University.

Read More: Autistic Children See Movement Twice as Quickly as Those Without Condition

David Mathews Heads Working Group Within New Center For Aids Research

Thursday, May 9, 2013

Dr. David Mathews will head one of the primary units within the recently announced $7.5M Center for Aids Research at the University. The NIH-funded center is one of only 18 in the country and brings together University scientists from numerous disciplines. Dr. Mathews, Associate Director of the Center for RNA Biology and Associate Professor within the Department of Biochemistry and Biophysics, will head the working group focused on the biology of the AIDS virus genome, which is comprised of RNA.

Read More: David Mathews Heads Working Group Within New Center For Aids Research

Enhanced Motion Detection in Autism May Point to Underlying Cause of the Disorder

Wednesday, May 8, 2013

Children with autism see simple movement twice as quickly as other children their age, and this hypersensitivity to motion may provide clues to a fundamental cause of the developmental disorder, according to a new study.

Such heightened sensory perception in autism may help explain why some people with the disorder are painfully sensitive to noise and bright lights. It also may be linked to some of the complex social and behavioral deficits associated with autism, says Duje Tadin, one of the lead authors on the study and an assistant professor of brain and cognitive sciences at the University of Rochester.

We think of autism as a social disorder because children with this condition often struggle with social interactions, but what we sometimes neglect is that almost everything we know about the world comes from our senses. Abnormalities in how a person sees or hears can have a profound effect on social communication.

Read More: Enhanced Motion Detection in Autism May Point to Underlying Cause of the Disorder

Stephen Dewhurst Named Vice Dean for Research at UR School of Medicine and Dentistry

Thursday, May 2, 2013

Stephen Dewhurst, Ph.D., has been named vice dean for research at the University of Rochester School of Medicine and Dentistry. A faculty member since 1990 and past senior associate dean for basic research, Dewhurst will lead the School’s research strategic planning process and help advance its research priorities by identifying areas of excellence in which to make strategic investments; strengthening the research infrastructure; improving education and training; and promoting collaborations and alliances that will result in increased research funding.

Read More: Stephen Dewhurst Named Vice Dean for Research at UR School of Medicine and Dentistry

Richard Aslin Elected to National Academy of Sciences

Wednesday, May 1, 2013

Richard Aslin

Dr. Richard Aslin

Richard Aslin, the William R. Kenan Professor of Brain and Cognitive Sciences and director of the Rochester Center for Brain Imaging at the University of Rochester, has been elected a member of the National Academy of Sciences (NAS).

Membership in the academy is one of the highest honors given to a scientist or engineer in the United States. Aslin will be inducted into the academy next April during its 151st annual meeting in Washington, D.C.

This honor is richly deserved. Dick is a pioneer in the field of cognitive development, said Peter Lennie, provost and the Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences and Engineering. His work has opened up a major new field and has transformed our understanding of how infants learn.

Read More: Richard Aslin Elected to National Academy of Sciences

Tara Capece Wins Second Place at Graduate Student Society Poster Competition

Wednesday, May 1, 2013

Tara Capece, a CVBI student in Minsoo Kim lab, won Second Place at the Graduate Student Society Poster Competition in recognition of outstanding presentation of thesis work The competition was held in the Sarah Flaum Atrium in April and involved students from all graduate programs at the University of Rochester Medical Center. Congratulations Tara!

Wilmot Cancer Center Update - May 2013

Wednesday, May 1, 2013

Mark Noble, Ph.D. and doctoral student Hsing-Yu Chen studied the molecular mechanism that allows basal-like breast cancer cells to escape the secondary effects of tamoxifen, and discovered that two proteins are critical in this escape.

The research, published in the journal EMBO Molecular Medicine, shows how to exploit tamoxifen's secondary activities so that it might work on more aggressive breast cancer—a promising development for women with basal-like breast cancer, sometimes known as triple-negative disease.

Researchers Identify New Pathway, Enhancing Tamoxifen to Tame Aggressive Breast Cancer

Tuesday, April 23, 2013

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen’s secondary activities so that it might work on more aggressive breast cancer.

The research, published in the journal EMBO Molecular Medicine, is a promising development for women with basal-like breast cancer, sometimes known as triple-negative disease. Led by doctoral student Hsing-Yu Chen and Mark Noble, Ph.D., professor of Biomedical Genetics at URMC, the team studied the molecular mechanism that allows basal-like breast cancer cells to escape the secondary effects of tamoxifen, and discovered that two proteins are critical in this escape.

Read More: Researchers Identify New Pathway, Enhancing Tamoxifen to Tame Aggressive Breast Cancer

URMC Biochemistry Professor Authors Paper in Science

Monday, April 22, 2013

Department of Biochemistry and Biophysics Professor Mark Dumont was the senior author on a paper published in the March 29, 2013 issue of Science. The work described the structure of the protein Ste24p, one of the proteins responsible for processing lipid-modified proteins in yeast and humans.

Molecular structure of the protein Ste24p.

Molecular structure of the protein Ste24p.

The research was performed in collaboration with scientists from the University of Virginia and the Hauptman Woodward Institute in Buffalo, as part of the Membrane Protein Structural Biology Consortium (MPSBC), funded by the National Institutes of Health Protein Structure Initiative. MPSBC is one of 9 membrane protein structure determination centers established in July 2010 as part of the NIGMS PSI: Biology Initiative.

MPSBC aims to establish a pipeline to generate multiple target constructs for expression studies followed by pre-crystallization screening to identify stable protein:detergent complexes. The complexes then undergo high-throughput crystallization screening and optimization followed by structure determination. Targets include transporters, transmembrane enzymes involved in lipid synthesis and lipid attachment, and membrane protein complexes.

NGP Graduate Student Kelli Fagan Wins Poster Award

Tuesday, April 9, 2013

Kelli Fagan, a third-year NGP student in Doug Portman's lab, won first place in the Multicellular/Organismal category the Graduate Student Society poster session held on Apr. 5, 2013. Kelli's poster was entitled Sexually dimorphic neuromodulatory signaling elicits sex differences in sensory behavior. Along with this honor comes an $800 travel award that will allow Kelli to present her work at the upcoming Cell Symposium on Genes, Circuits and Behavior in Toronto, Canada. Congratulations, Kelli!

BME Rochester Teams Advance in Business Plan Contest

Monday, April 8, 2013

Photo of the MedThru ICT team

MedThru ICT (Alvin Lomibao,
Nick Lewandowski, Sarah
Catheline, Nirish Kafle)

Among the six University teams that have advanced to the New York Business Plan Competition finals, the Department of Biomedical Engineering has two teams vying for the top spot. The finalists include BME undergraduate team, TrakOR (W. Spencer Klubben, Ankit Medhekar, Michael Nolan, Sonja Page, Matt Plakosh, Erin Schnellinger) in the biotech/healthcare category and graduate team, MedThru ICT (Sarah Catheline, Nirish Kafle, Nick Lewandowski, Alvin Lomibao) in the information technology/software category.

Through the clinical rotations in the CMTI masters program, I was able to get a sense of a day in the life of staff members in the cardiac catheterization laboratory--how they interact with technology and medical devices, what they're really good at, and what frustrates them. In developing the MedThru ICT system, we've considered a number of these pain points and developed a way to facilitate resource management when critical decisions need to be made. This way, providers can really focus on the patient and not on logistics. We hope that downstream this system can have applications in other hospital units, decreasing the cost of healthcare overall, says Alvin Lomibao.

The finals will take place in Albany on April 26, where the two teams will vie for $225,000 in cash and in-kind prizes. The New York Business Plan Competition is the only leading collegiate business competition that is a regionally coordinated, collaborative statewide program, which sets it apart from all other competitions. It is one of the largest collegiate business competitions in the nation.

Rochester Named One of Techie.com's Most Most Unexpected Cities for High-Tech Innovation

Monday, April 8, 2013

photo of the Frederick Douglass–Susan B. Anthony Memorial Bridge

Rochester, NY

There are a handful of cities we think of, when we think of high-tech innovation and startups: San Francisco, New York, London, Bangalore, Tel Aviv . . . but today, high-tech development has been democratized. Easy and cheap availability of cloud-based resources, sophisticated telecommunications tools, platforms-as-a-service and lean models that accelerate the development and deployment process, and – sorry, California – a net outmigration from traditional tech centers, has already started to shift high-tech development to the most unlikely places.

One of these places is Rochester, NY, where roughly half a billion dollars worth of research is conducted annually at RIT and UR. A portion of the healthy $749,994 grant from the National Science Foundation's Robert Noyce Scholarship Program awarded to UR in 2012 is allocated to addressing the shortage of highly qualified math and science teachers in the area by providing full-tuition scholarships to undergraduates pursuing these educational careers.

NGP Graduate Student, Revathi Balasubramanian, Wins Award for Excellence in Teaching

Thursday, April 4, 2013

NGP student Revathi Balasubramanian and Dr. Barbara Davis

Revathi Balasubramanian and her mentor,
Dr. Barbara Davis.

Revathi Balasubramanian, a Neuroscience Graduate Program student in Dr. Lin Gan's lab, studying the role of transcription factors in retinal neurogenesis, has been named a winner of the 2013 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. Only a handful of these are awarded each year, and all this year's nominees were extremely well-qualified. Congratulations Revathi!

NGP Graduate Student Ryan Dawes Awarded Grant from the Breast Cancer Coalition of Rochester

Wednesday, March 27, 2013

Neuroscience Graduate Program student, Ryan Dawes, has been awarded a 2013 Breast Cancer Research Grant, from the Breast Cancer Coalition of Rochester. The 1-year, $50,000 grant will fund his project, entitled Breast Cancer Exosomes, Novel Intermediaries in Psychosocial Stress-induced Tumor Pathogenesis and was only one of two applications to be awarded this prestigious grant. This work will investigate if psychosocial stress can modulate the number or content of secreted small vesicles (exosomes), and determine if this can alter the process of tumorigenesis in an animal model of spontaneous breast cancer as Ryan continues his research in Dr. Edward Brown's lab.

NPR Features Current Nedergaard-Goldman Publication; Glial Research

Thursday, March 7, 2013

Human glial cell within mouse glial cells

A human glial cell (green) among normal mouse glial cells (red). The human cell is larger, sends out more fibers and has more connections than do mouse cells. Mice with this type of human cell implanted in their brains perform better on learning and memory tests than do typical mice.

For more than a century, neurons have been the superstars of the brain. Their less glamorous partners, glial cells, can't send electric signals, and so they've been mostly ignored. Now scientists have injected some human glial cells into the brains of newborn mice. When the mice grew up, they were faster learners. The study, published Thursday in Cell Stem Cell by Maiken Nedergaard, M.D., D.M.Sc. and Dr. Steven Goldman, M.D., Ph.D., not only introduces a new tool to study the mechanisms of the human brain, it supports the hypothesis that glial cells - and not just neurons - play an important role in learning.

Today, glial research and Dr. Goldman were featured on National Public Radio (NPR) speaking about the glial research that is outlined in this current publication. I can't tell the differences between a neuron from a bird or a mouse or a primate or a human, says Goldman, glial cells are easy to tell apart. Human glial cells - human astrocytes - are much larger than those of lower species. They have more fibers and they send those fibers out over greater distances.

In collaboration with the Nedergaard Lab, newborn mice had some human glial cells injected into their brains. The mice grew up, and so did the human glial cells. The cells spread through the mouse brain, integrating perfectly with mouse neurons and, in some areas, outnumbering their mouse counterparts. All the while Goldman says the glial cells maintained their human characteristics.

Read More: NPR Features Current Nedergaard-Goldman Publication; Glial Research

Support Cells Found in Human Brain Make Mice Smarter

Thursday, March 7, 2013

Glial cells – a family of cells found in the human central nervous system and, until recently, considered mere housekeepers – now appear to be essential to the unique complexity of the human brain. Scientists reached this conclusion after demonstrating that when transplanted into mice, these human cells could influence communication within the brain, allowing the animals to learn more rapidly.

The study, out today in the journal Cell Stem Cell, suggests that the evolution of a subset of glia called astrocytes – which are larger and more complex in humans than other species – may have been one of the key events that led to the higher cognitive functions that distinguish us from other species.

The role of the astrocyte is to provide the perfect environment for neural transmission, said Maiken Nedergaard, M.D., D.M.Sc., co-senior author of the study and director, along with Dr. Steven Goldman, M.D., Ph.D., of the URMC Center for Translational Neuromedicine. As the same time, we've observed that as these cells have evolved in complexity, size, and diversity – as they have in humans – brain function becomes more and more complex.

Read More: Support Cells Found in Human Brain Make Mice Smarter

Josh Munger, Ph.D. Discusses Jobs in Biochemistry and Biophysics with the Rochester Democrat and Chronicle

Monday, February 25, 2013

Joshua Munger was studying to become a veterinarian, but a microbiology requirement in college — in which he learned about the constant fight between host cells and the viruses that attack them — changed everything. There's this evolutionary battle between the two,” he said. “I enjoyed learning about how they're always one-upping each other, how they're always trying to either cause infection or to limit the infection.

Munger, 37, has been an assistant professor in the Department of Biochemistry and Biophysics at the University of Rochester Medical Center since 2008. His work, which looks at how viral infection changes the metabolism of cells, has implications for cancer research and other areas.

URMC Biochemistry Professor Named a Fellow of the American Academy of Microbiology

Friday, February 15, 2013

Eric Phizicky, Ph.D.

Eric Phizicky, Ph.D.

Eric M. Phizicky, Ph.D., dean's professor in the Department of Biochemistry and Biophysics and member of the University's Center for RNA Biology, has been elected to Fellowship in the American Academy of Microbiology (Academy). The Academy is the honorific leadership group within the American Society for Microbiology (ASM), the world's oldest and largest life science organization. The mission of the Academy is to recognize scientists for outstanding contributions to microbiology and provide microbiological expertise in the service of science and the public.

Over the last 50 years, over 2,700 distinguished scientists have been elected to the Academy. Fellows are elected through a highly selective, annual, peer review process, based on their records of scientific achievement and original contributions that have advanced microbiology. Each elected Fellow has built an exemplary career in basic and applied research, teaching, clinical and public health, industry or government service. Academy Fellows are eminent leaders in the field of microbiology and are relied upon for authoritative advice and information on critical issues in microbiology. Election to Fellowship indicates recognition of distinction in microbiology by one's peers.

We couldn't be more pleased that Eric has been awarded this honor and recognition for his excellence and creativity in the microbiological sciences, said Jeffrey J. Hayes, Ph.D., professor and acting chairman of the Department of Biochemistry and Biophysics at the Medical Center. On behalf of the department, please join me in offering his well-deserved congratulations!

Phizicky, who came to the Medical Center in 1987, has spent his career working to understand how tRNA is made and how it does its job in the cell, which is to help with the translation of genes into proteins. His lab also focuses on the design, construction and implementation of genomic methods to analyze protein structure and function, work that's conducted in collaboration with Elizabeth Grayhack, Ph.D., associate professor of Biochemistry and Biophysics.

NGP Student, Simantini Ghosh, Wins Travel Award to AD/PD Conference

Monday, February 11, 2013

Simantini Ghost receiving Travel Award at AD/PD Conference

Simantini receiving the award from AD/PD conference chair,
Dr. Roger Nitsch.

Congratulations to NGP Graduate Student, Simantini Ghosh on winning a travel award to present her work at the 11th International Conference on Alzheimer's & Parkinson's Disease in Florence, Italy on March 6-10, 2013. Simi works in Dr. Kerry O'Banion's lab, studying the effects of sustained Interleukin 1 beta overexpression on Alzheimer's disease pathology in transgenic mice.

NGP Student, Anasuya Das, Wins Travel Award to ECVP

Wednesday, February 6, 2013

Congratulations to NGP Graduate Student, Anasuya Das on winning a travel award to present her work at the European Conference on Visual Perception (ECVP) in Alghero, Italy on September 2-6, 2012. Anasuya works in Dr. Krystel Huxlin's lab in the Visual Training & Rehabilitation Lab. Her poster was entitled, Beyond blindsight: perceptual re-learning of visual motion discrimination in cortical blindness improves static orientation discrimination.

Hocking, Roy Image Selected as Cover Art for Tissue Engineering, Part B

Saturday, February 2, 2013

Cover Art for Tissue Engineering, Part B

An image by Dr. Denise C. Hocking and Dr. Daniel C. Roy was selected as cover art for Tissue Engineering, Part B: Reviews, Volume 19, Number 1, February 2013. The image consists of human mesenchymal stem cells adherent to a recombinant fibronectin mimetic substrate polymerize an endogenous fibronectin matrix (green) using α5β1 integrins (red).

Study: Model for Brain Signaling Flawed

Thursday, January 10, 2013

A new study out today in the journal Science turns two decades of understanding about how brain cells communicate on its head. The study demonstrates that the tripartite synapse – a model long accepted by the scientific community and one in which multiple cells collaborate to move signals in the central nervous system – does not exist in the adult brain.

Our findings demonstrate that the tripartite synaptic model is incorrect, said Maiken Nedergaard, M.D., D.M.Sc., lead author of the study and co-director of the University of Rochester Medical Center (URMC) Center for Translational Neuromedicine. This concept does not represent the process for transmitting signals between neurons in the brain beyond the developmental stage.

Read More: Study: Model for Brain Signaling Flawed

URMC Biochemistry Professor Named University of Rochester 2013 Presidential Diversity Award Recipient

Thursday, January 10, 2013

University of Rochester President Joel Seligman, with 2013 Diversity Award winners

University of Rochester President Joel Seligman, with 2013 Diversity Award winners Suzanne Piotrowski (THSP), Kevin Graham (THSP), Alyssa Cannarozzo (THSP), Lynne Maquat of the Medical Center, Kim Muratore (THSP), and Vice Provost for Faculty Development & Diversity Vivian Lewis.

Lynne Maquat, Ph.D., J. Lowell Orbison Endowed Chair & Professor, Biochemistry & Biophysics; Director, University of Rochester Center for RNA Biology: From Genome to Therapeutics; Chair, University of Rochester Graduate Women in Science, has been selected to receive one of two 2013 Presidential Diversity Awards for exemplary contributions to the University's diversity and inclusion efforts. Dr. Maquat is being honored for combining her groundbreaking research agenda with a lifelong commitment to helping women succeed in science. Her remarkable accomplishments include the networking and mentoring programs she initiated as president of the RNA Society; her creation in 2003 of the University of Rochester Graduate Women in Science (GWIS) program; and her award and renewal of an NIH training grant that supports graduate students, including underrepresented minorities, in the cellular, biochemical and molecular sciences.

The Presidential Diversity Awards were created in 2009 by President Joel Seligman to recognize faculty, staff, students, units, departments or teams that demonstrate a commitment to diversity and inclusion through recruitment and retention efforts, teaching, research, multi-cultural programming, cultural competency, community outreach activities, or other initiatives.

Read More: URMC Biochemistry Professor Named University of Rochester 2013 Presidential Diversity Award Recipient

A Trip to Mars Could Increase Chances of Alzheimer's for Astronauts

Thursday, January 3, 2013

As if space travel was not already filled with enough dangers, a new study out today in the journal PLOS ONE shows that cosmic radiation – which would bombard astronauts on deep space missions to places like Mars – could accelerate the onset of Alzheimer's disease.

Galactic cosmic radiation poses a significant threat to future astronauts, said M. Kerry O'Banion, M.D., Ph.D., a professor in the University of Rochester Medical Center (URMC) Department of Neurobiology & Anatomy and the senior author of the study. The possibility that radiation exposure in space may give rise to health problems such as cancer has long been recognized. However, this study shows for the first time that exposure to radiation levels equivalent to a mission to Mars could produce cognitive problems and speed up changes in the brain that are associated with Alzheimer's disease.

Congratulations to Michael Baranello for a Successful Qualifying Exam!

Saturday, September 15, 2012

Congratulations to Michael Baranello for a Successful Qualifying Exam! Mike is currently a graduate student in the Benoit Lab, and his current project is Use of Polymer Micelles to Enhance Cancer Therapeutics

Projects by Engineering Students Shown on Video

Thursday, June 21, 2012

Each spring, seniors in computer science, optics, biomedical, computer and electrical, chemical and mechanical engineering at the Hajim School present the projects they have worked on all year. Students work in teams to solve a problem brought to them by a customer from outside the University. See below for the video of their projects.

Read More: Projects by Engineering Students Shown on Video

Funding Awarded to Senior Design Project

Friday, June 15, 2012

Neonatal prototype of respiratory monitor

 

The UR Technology Development fund has decided to invest approximately $50,000 toward the development of a product designed by a Senior Design Team in Biomedical Engineering. Benjamin Horowitz, Megan Makarski, William Sipprell, and Robert Handzel (Biomedical Engineering, '09), working with Strong Neonatologists Timothy Stevens, M.D., and Patricia Chess, M.D., designed and prototyped a respiration monitor for use on very low birth weight newborns. With this funding, which was awarded to Scott Seidman, Ph.D., Associate Professor of Biomedical Engineering and Neurobiology & Anatomy, a second-generation prototype ready for introduction into the Neonatal Intensive Care Unit will be constructed and tested, with the clear aim of getting this life-saving technology onto the market.

Hajim Design Day Students Featured on WHAM13 News and YNN

Thursday, May 3, 2012

Engineering students, Silvia Perucchio (Mechanical Engineering) and Doug Clift (BME) spoke with WHAM 13 News about Hajim Design Day 2012 and the design project they are working on. Hajim Design Day 2012 was held on Thursday, May 3 and showcased engineering students Real-World solutions for the community. YNN also featured Hajim Design Day 2012 as the students got to show off their products during today's Design Day at the school.

Student teams at the University's Hajim School of Engineering and Applied Sciences have been partnering with local companies and institutions over the past year to solve real-world engineering problems. The students demonstrated their results from 12-2 p.m. in the Munnerlyn Atrium of Robert B. Goergen Hall. To learn more about this event see the Hajim Design Day project images.

BME Students Receive Whitaker Fellowships

Tuesday, April 10, 2012

Two UR seniors in BME and an alumna who graduated last year have won prestigious Whitaker International Fellows awards. The program is managed by the Institute for International Education, the same organization that manages the Fulbright Fellowship awards. The goal of the program is to provide students who show potential for leadership in Biomedical Engineering the opportunity to obtain international experience either in education or research (or both) after they have completed their undergraduate degree.

Catherine Marando's (UR BME '12) award is to engage in research related to the study and treatment of glaucoma at Imperial College in London. Douglas Clift (UR BME '12) will be using his award to study musculoskeletal tissue engineering and biomaterials development at the Institute for Bioengineering of Catalonia in Barcelona Spain. Kelli Summers (UR BME '11) will be going to Vienna Austria to study methods and mechanisms for developing molecular contrast agents for magnetic resonance imaging.

Biochemistry and Biophysics Graduate Students Receive Fellowship Awards

Thursday, October 6, 2011

At this year's opening convocation on October 5, two graduate students from the department of Biochemistry & Biophysics received Graduate Fellowship's. Dejun Lin, a Ph.D. student in the Biophysics, Structural and Computational Biology graduate program, was awarded the Leon L. Miller Graduate Fellowship. This fellowship, established by the Miller family, honors Dr. Leon Miller, Professor Emeritus of Biochemistry & Biophysics, for his contributions to science and the School of Medicine and Dentistry. It is awarded annually to a student with interest in developing a biophysics-related research career.

Sarah Amie, a Ph.D. student in the Biochemistry and Molecular Biology graduate program, was awarded the Elmer H. Stotz Graduate Fellowship. This fellowship, established by the Stotz family to honor Dr. Elmer Stotz, Professor Emeritus and former Chair of the Department of Biochemistry, is awarded to a Ph.D. student in biochemistry.

MSTP Student Elected to Board of SNMA

Thursday, October 6, 2011

Bisi Lawal, an M.D./Ph.D. student at the University of Rochester School of Medicine and Dentistry, has been elected to the board of directors of the Student National Medical Association (SNMA). Lawal, a native of Houston, is the regional director for medical schools in New York and New Jersey. The SNMA is the nation's oldest and largest, independent, student-run organization focused on the needs and concerns of medical students of color.

NGP Graduate Student Receives F30 NIH Individual Predoctoral Fellowship

Wednesday, September 28, 2011

Neuroscience graduate program student, Phillip Rappold has received an F30 NIH Individual Predoctoral Fellowship for 3 years, entitled Role of mitochondrial dynamics in Parkinson's disease processes and therapeutics.

NGP Graduate Student Receives Irving L. Spar Fellowship Award

Thursday, September 22, 2011

First year student in the Neuroscience graduate program, Jennifer Stripay has been selected by the faculty to be this year's recipient of the Irving L. Spar Fellowship Award. Jennifer's selection was based on her outstanding credentials and the faculty opinion that she has unusual potential for future meritorious contributions in her field. The Irving L. Spar Fellowship Award honors the memory of Dr. Spar, a former Senior Associate Dean for Graduate Studies in the School of Medicine and Dentistry. It is awarded annually to a deserving graduate student entering the School through the Graduate Education in the Biomedical Sciences Program.

MSTP, NSC Graduate Student Receives F30 Fellowship

Thursday, September 8, 2011

MSTP, NSC graduate student, Adrianne Chesser, has received an F30 Fellowship from the National Institute of Environmental Health Sciences, for her project entitled: Mitochondrial Dynamics Underlie Gene-Environment Interactions in Parkinson's. The mission of the NIEHS is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.

2011 NGP Students Receive Funding From NINDS

Wednesday, August 31, 2011

Recently the National Institute of Neurological Disorders and Stroke (NINDS) awarded several of our Neuroscience graduate students training grants. This year, a first year NGP student, Jennifer Stripay, as well as second year students, Kelli Fagan, Julianne Feola, John O'Donnell, Fatima Rivera-Escalera, Grayson Sipe received funding. NINDS is funded by the National Institutes of Health (NIH), with it's continuing mission to reduce the burden of neurological disease - a burden borne by every age group, by every segment of society, by people all over the world.

BME Grad Student Michael Hoffman Wins the Sodus Point Sprint Triathlon

Tuesday, August 16, 2011

Photo of Michael Hoffman running

Michael Hoffmann

Congratulations to BME graduate student, Michael Hoffman, who won the Sodus Point Sprint Triathlon on August 14th. The triathlon consisted of a .45 mile swim, 13.1 mile bike, and 5K run. Michael is a current member of the Benoit Lab, working on the tissue engineered periosteum approaches to heal bone allograft transplants project.

Amy Van Hove Awarded the Howard Hughes Medical Institute Med-into-Grad Fellowship

Monday, August 1, 2011

Amy Van Hove, a graduate student in the Benoit lab has been awarded the Howard Hughes Medical Institute Med-into-Grad Fellowship in Cardiovascular Science. This prestigious Howard Hughes Medical Institute fellowship is sponsored by the Aab Cardiovascular Research Institute (CVRI) and augments traditional Ph.D. training with clinical rotations, a clinical co-mentor, weekly CVRI seminar series, journal club, and translational cardiovascular coursework to train the next generation of bench-to-bedside cardiovascular scientists.

MSTP, NSC Graduate Student Susan Lee Receives Trainee Travel Award

Thursday, April 7, 2011

MSTP and Neuroscience student, Susan Lee has received a Trainee Travel Award to present her research at the Organization for Human Brain Mapping's 17th Annual Meeting in Quebec City, Canada on June 26-30, 2011. Susan is currently working in Dr. Loisa Bennetto's lab on Audiovisual Integration During Language Comprehension: The Neural Basis of Social Communication in Autism and Typical Development.

BME Students Awarded Fellowships for Graduate Research by the National Science Foundation

Wednesday, April 6, 2011

Three BME seniors received prestigious National Science Foundation Research Fellowships, and Michael Hoffman, a Ph.D. student in the Benoit Lab, received an NSF Honorable Mention. The fellowship, which is part of a federally sponsored program, provides up to three years of graduate study support for students pursing doctoral or research-based master's degrees.

The fellowship includes a three-year annual stipend of $30,000, a $10,500 educational allowance to the institution, and international research opportunities. Danielle Benoit, assistant professor in biomedical and chemical engineering at Rochester, says that the financial support provides students the flexibility to attend conferences, participate in training programs, and travel to meet with other researchers in their field.

The following graduating BME seniors received fellowships:

Benjamin Freedman (Lerner Lab) '11
University of Pennsylvania
Adam Kozak '11
Duke University
Hannah Watkins (Benoit Lab) '11
Cornell University
2011-12 Fullbright Scholarship and Whitaker International Fellowship to the United Kingdom
Read More: BME Students Awarded Fellowships for Graduate Research by the National Science Foundation

Wei Jiang Successfully Defends PhD Thesis

Wednesday, March 23, 2011

Wei Jiang (ECE) successfully defended his Ph.D. thesis titled Ultrasound Focusing by Use of Apertures with Different Pitches and Ultrasound Imaging by Use of a Hemispheric Transducer Array. Wei's research was completed under the supervision of Professor Robert C. Waag, Ph.D. of the Department of Electrical and Computer Engineering.

Youngsun Cho (MSTP) Takes the Reins at the ACNP Annual Meeting

Monday, January 24, 2011

MSTP student Youngsun Cho was the recipient of an NIMH-sponsored Travel Award to this year's American College of Neuropsychopharmacology (ACNP) Annual Meeting in Miami, Florida, in December. In an unexpected twist, she graciously stepped in to present data for our panel entitled, How Does Anxiety Take Hold? Anatomical and Functional Connectivity in Adolescents and Adults, organized by Drs. Monique Ernst and Julie Fudge. Earlier in the meeting, Youngsun also presented a poster of recent work collected and analyzed during her NIMH 'mini-sabbatical'. She is examining the functional connectivity of prefrontal-amygdala-striatal circuits in adolescents and adults, and her presentation was entitled Neural Differences in Adolescents and Adults in Response to Monetary Anticipation.

We're looking forward to having Youngsun back in Rochester during the month of February!

Hocking & Dalecki Research Image Featured on Cover of Tissue Engineering

Friday, December 10, 2010

An immunofluorescence image captured by two-photon microscopy by Carlos Sevilla, has been featured as the cover for the December issue of Tissue Engineering. The image is featured in an article by BME graduate student Carlos Sevilla, co-authored by Dr. Dalecki and Dr. Denise Hocking.

The article entitled, Extracellular Matrix Fibronectin Stimulates the Self-Assembly of Microtissues on Native Collagen Gels, demonstrates a novel role for cell-mediated fibronectin fibrillogenesis in the formation and vertical assembly of microtissues, and provide a novel approach for engineering complex tissue architecture.

Read More: Hocking & Dalecki Research Image Featured on Cover of Tissue Engineering

The Pericyte Becomes a Player in Alzheimer’s, Other Neurodegenerative Diseases

Wednesday, November 17, 2010

PDGFR + Pericytes

PDGFRβ+ Pericytes

Cells in the brain called pericytes that have not been high on the list of targets for treating diseases like Alzheimer's may play a more crucial role in the development of neurodegenerative diseases than has been realized. The findings, published Nov. 4 in Neuron, cast the pericyte in a surprising new role as a key player shaping blood flow in the brain and protecting sensitive brain tissue from harmful substances.

For 150 years these cells have been known to exist in the brain, but we haven't known exactly what they are doing in adults, said Berislav Zlokovic, M.D., Ph.D., the neuroscientist who led the research at the University of Rochester Medical Center.

In the most recent findings from Zlokovic's laboratory, the two first authors who contributed equally to the research, graduate student Robert Bell and M.D./Ph.D. and Neuroscience student Ethan Winkler, teased out the role of the pericyte in the process. Pericytes ensheath the smallest blood vessels in the brain, wrapping around capillaries like ivy wrapping around a pipe and helping to maintain the structural integrity of the vessels.

Read More: The Pericyte Becomes a Player in Alzheimer’s, Other Neurodegenerative Diseases

BME Graduate Featured in Rochester Business Journal

Friday, October 1, 2010

photo of Erin Harner

Erin Harner, UR BME Graduate

Erin Harner recently received her master's degree from the UR BME program, and launched a new career as a health counselor focusing on nutrition. Although her training in cutting edge biomedical engineering may seem worlds away from her new business, Second Nature Wellness, she thinks her UR experience has helped her in many ways - both directly and indirectly.

During my time at the University of Rochester, I learned many life lessons that serve me everyday in my new career as a health and nutrition coach. There is so much confusion and misinformation in the field of health and nutrition, and I feel that my education in biomedical engineering and immense background in biology, chemistry, anatomy, physiology, and a systems-approach to the body help me to look beyond the new idea of the day and back to the science. I constantly ask myself, with everything I know, does this make sense? Being an independent thinker is extremely important, and I credit the UR with helping to cultivate that in me, says Erin.

Erin's story has been featured in this month's Rochester Business Journal.

BME Graduate Student Javier Lapeira Soto Receives DoD Predoctoral Traineeship Award

Tuesday, August 10, 2010

BME graduate student, Javier Lapeira Soto, a current member of the Brown Lab, has been awarded a 2010 Predoctoral Traineeship Award from the Department of Defense (DoD) Breast Cancer Research Program (BCRP) based on the high scientific merit of his application, Breast Cancer Endothelial Cell Calcium Dynamics Using Two-Photon Microscopy, and its relevance to the programmatic goals of the BCRP.

NBA Students Win First Prize at 8th Annual Collier Mental Health Poster Session

Wednesday, March 31, 2010

Michele Saul (NBA graduate student) and Dan Tylee (undergraduate assistant) each won first prize honors at the 8th Annual Collier Mental Health Poster Session, sponsored by the Department of Psychiatry. Michele presented new work on the effects of stress on amygdala development in adolescent animals. Dan’s showed that a coping behavior during stress ameliorates subsequent anxiety behavior in adult animals.

New NIH Training Grant for Hearing, Balance, and Spatial Orientation Research

Friday, March 5, 2010

The University of Rochester has recently been awarded a Training Grant (T32) from the NIH National Institute on Deafness and Other Communication Disorders entitled Training in Hearing, Balance, and Spatial Orientation. This Training Grant involves the collaborative efforts of the Departments of Otolaryngology, Biomedical Engineering, and Neurobiology & Anatomy. The Grant will support PhD students, MD-PhD students, Post-doctoral fellows and Medical Residents in BME, Neuroscience, and Otolaryngology who are involved in research related to the auditory and vestibular systems. This Training Grant is an important resource for the University of Rochester's Center for Navigation and Communication Sciences, which provides technical and administrative support for 25 faculty members who are conducting research in this area. The 5-year grant will provide approximately $1.5 million dollars of support for several trainees each year. In association with the Training Grant, a new graduate-level course entitled Hearing and Balance: Structure, Function and Disease will be offered starting in Fall 2010. This new Training Grant is an exciting advance for the strong and growing community of auditory and vestibular researchers at the University of Rochester.

Members of the BME Graduate Program Vie for Top Place in the JPMorgan Chase Corporate Challenge Championship

Wednesday, January 6, 2010

photo of the Snyder Corporation event

Representing UR in the JPMorgan
Chase Corporate Challenge
Championship will be Jessica Snyder
(left and far right in inset photo)
and (from left in inset photo) Luke
Mortensen, Christina Devries and Chris Hiner.

Jessica Snyder, a biophysics graduate student and member of Jim McGrath's biomedical engineering lab, credits her work as an elite cross-country skier in helping her become the third place female finisher in the Rochester Chase Corporate Challenge last May, which contributed to the University of Rochester (UR) team's win of the mixed team title. The four-member team will now travel to Johannesburg, South Africa for the Championship in March.

Joining Jessica will be Luke Mortensen, a graduate student in Biomedical Engineering; Chris Hine, a graduate student in biochemistry and biophysics; and Christina Devries, a technical associate at the Center for Human Genetics and Molecular Pediatric Disease.

Read More: Members of the BME Graduate Program Vie for Top Place in the JPMorgan Chase Corporate Challenge Championship

NSC Graduate Student, Cory Hussar, Publishes an Article in December 2009 Edition of Neuron

Monday, December 14, 2009

Cory Hussar, a 5th year Neuroscience graduate student in Dr. Tania Pasternak's lab (NBA) has published an article in this month's edition of Neuron. The article, entitled Flexibility of sensory representations in prefrontal cortex depends on cell type, reports that neurons in prefrontal cortex (PFC) represent visual motion with precision comparable to cortical neurons at early stages of motion processing, and readily adapt this representation to behavioral context. Furthermore, results show that flexible sensory representation during active discrimination tasks is achieved in the PFC by a specialized neuronal network of both NS neurons readily adjusting their selectivity to behavioral context, and BS neurons capable of maintaining relatively stable sensory representation.

Helen Wei and Youngsun Cho Accepted into MSTP Program

Wednesday, December 9, 2009

Congratulations to Helen Wei and Youngsun Cho, both recently accepted into the MSTP (MD-PhD program) from the MD-MS Program in Medical Neurobiology. We are delighted to welcome them to a continued and augmented commitment to neuroscience research as they now pursue their PhD candidacy and thesis projects.

BME Department makes a record showing at the Biomedical Engineering Society - Student Chapter wins Meritorious Achievement Award

Saturday, October 10, 2009

Photo of BME students

BME students receiving the Meritorious Achievement Award, recognizing the best student chapter in the nation.

Dozens of UR students and faculty attended the Biomedical Engineering Society Annual Meeting in Pittsburgh, PA from October 7-10. Our group gave 12 oral presentations and presented 17 posters demonstrating work in many areas of the department's research, including imaging, orthopaedics, tissue engineering, neuroengineering, nanotechnology, and cellular mechanics. The work was presented by faculty, graduate students and undergraduates, and also included examples of both translational research and educational outreach programs. The department also hosted an exhibit booth to meet with prospective students and faculty.

The annual meeting also offered numerous activities for students, related to research and career development. Perhaps most exciting was that our student BMES chapter received a Meritorious Achievement Award. This recognizes the best student chapter in the nation for achievements during the last academic year, based on last year's Chapter Development Report.

Read More: BME Department makes a record showing at the Biomedical Engineering Society - Student Chapter wins Meritorious Achievement Award

BME Graduate Sarah Lancianese wins Young Investigator Award

Monday, September 14, 2009

Recent graduate Sarah Lancianese received a Young Investigator Award at the 2009 World Congress on Osteoarthritis in Montreal, Quebec. She presented her work on the use of biomechanical models to understand risks for knee osteoarthritis in a plenary session including the 6 highest rated abstracts from young investigators. This abstract represented the final chapter of her PhD dissertation which she defended in July, 2009. The overall project, supervised by BME Associate Professor Amy L. Lerner, investigated the combined effects of obesity, limb alignment and bone mechanical properties on the knee joint. Dr. Lancianese is now a design engineer at Wright Medical, Inc. in Memphis TN.

Alumnus Christopher Kumar's Student Team Wins American Society for Engineering Education (ASEE) Competition

Wednesday, June 24, 2009

Alumnus Christopher Kumar, now a science instructor at Monroe Community College, led his student design team to a first place finish at the American Society for Engineering Education's National Robotics Competition. Kumar's student team, Tinkerballz, won the design title by creating a robot that could sort colored golf balls and deposit them in corresponding targets. Chris completed is BS in our BME Undergraduate program in 2003, then continued as a research technician and MS student with Greg Gdowski. After receiving hs MS degree in 2008, he joined the faculty at Monroe Community College as an instructor in the Department of Engineering & Physics.

Carlos Sevilla Awarded NIH Pre-doctoral Fellowship

Tuesday, June 16, 2009

Carlos Sevilla was awarded a prestigious NIH Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship. This three-year award will provide funding for Carlos' thesis research project, titled ,Promoting Chronic Wound Healing with Ultrasound and Fibronectin. In his research, Carlos is investigating the ability of ultrasound to produce conformational changes in the extracellular matrix protein fibronectin that, in turn, stimulate cellular processes important for accelerating soft tissue wound repair. Carlos is a third year graduate student in the Department of Biomedical Engineering and his thesis research is co-advised by Dr. Denise Hocking and Dr. Diane Dalecki. Carlos is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Carlos' research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop the use of ultrasound for chronic wound therapy.

Kelley Garvin Wins Best Student Paper Competition

Friday, June 5, 2009

Kelley Garvin won the Best Student Paper Competition at the 157th Meeting of the Acoustical Society of America held in Portland, OR from May 18-22. Her paper, titled Ultrasound standing wave fields control the spatial distribution of cells and protein in three-dimensional engineered tissue, was recognized as the best student paper in the Biomedical Ultrasound / Bioresponse to Vibration Technical Section. Kelley presented her recent work demonstrating the use of ultrasound fields to non-invasively control the spatial locations of cells in collagen-based engineered tissues. Ultrasound standing wave fields were used to organize cells into planar bands within collagen gels, resulting in a significant two-fold increase in cell-mediated gel contraction, suggesting that ultrasound-induced cell organization leads to a differential extracellular matrix remodeling. Further, using ultrasound to spatially band endothelial cells within collagen gels resulted in vessel sprouting. These novel technologies have important applications to the fabrication of engineered tissues with desired tissue characteristics. Kelley is a third year graduate student in the Department of Biomedical Engineering (BME) and her thesis research is co-advised by Dr. Diane Dalecki and Dr. Denise Hocking. Kelley is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU). Kelley's research is part of a larger, multidisciplinary project, led by Drs. Dalecki and Hocking and funded by the NIH, that aims to develop novel ultrasound technologies for the field of tissue engineering.

Lisa Bonanno Awarded NIH Pre-doctoral Fellowship

Friday, May 1, 2009

Lisa Bonanno was awarded a prestigious NIH Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral Fellowship. This two-year award will provide funding for Lisa's thesis research project to develop label-free porous silicon optical biosensors. Lisa's research is focused on designing sensors to detect molecules of interest in complex biological fluids (blood, urine etc.) for point-of-care diagnostic applications. This work is aimed at improving patient health care by reducing the time and cost associated with clinical laboratory testing. In particular, the fellowship award, entitled, Drug Screening with Nano-Porous Silicon Optical Biosensors is focused on designing sensors to detect small molecule drugs of abuse in urine. This multidisciplinary study is co-sponsored by Dr. Jean Bidlack in the Department of Pharmacology and Physiology. Lisa is a fourth year graduate student in the Department of Biomedical Engineering and her thesis research is advised by Dr. Lisa DeLouise in the Department of Dermatology.

Tony Chen Presents Two Papers at the 55th Annual Meeting of the Orthopaedic Research Society

Wednesday, February 25, 2009

Photo of Tony Chen

Tony Chen, Ph.D. candidate, presenting at the Orthopaedic Research Society Meeting.

Tony Chen, Ph.D. Candidate, presented two papers at the 55th Annual Meeting of the Orthopaedic Research Society in Las Vegas, NV (February 22 - 25, 2009). The papers he presented were:

  • Chen T, Jeffries R, Zuscik M, Awad H. Anabolic Effects of TGF-beta1 and Low Oxygen on Bioreactor-Cultivated Tissue Engineered Cartilage, and
  • Chen T, Zuscik M, Awad H. Interstitial Flow Produces a Superficial Zone-Like Layer in Tissue Engineered Cartilage.

UR BME Faculty, Students and Alumni at the 2009 Orthopaedic Research Society Annual Meeting

Wednesday, February 25, 2009

The UR Biomedical Engineering Program was well represented at this year's Annual Meeting of the Orthopaedic Research Society in Las Vegas, Nevada. In addition to several podium and poster presentations by current members of the BME department, it was great to connect with many alumni of the program, who have gone on to graduate degrees, positions in industry, or post-doctoral fellowships. For example, presenting their work at this year's ORS were UG alums Suzanne Ferreri ('01), Tunde Babalola ('02), Jason Long ('03), Dan Xia Chen ('05), Andrea Pallante ('05), Jedd Sereysky ('05), Nick Drury ('06) and Carrie Voycheck ('06). Their presentations included studies of cartilage tissue engineering, tendon properties, finite element modeling, and the effects of ultrasound.

Candace Gildner wins Ruth Kirchstein National Research Service Award for MD/PhD Studies

Tuesday, February 17, 2009

Candace Gildner, an MD/PhD student in the Biomedical Engineering Department, has recently been awarded a Ruth L. Kirschstein National Research Service Award for Individual MD/PHD Fellows from the NIH. This prestigious, four-year award covers her PhD research as well as her remaining two years in medical school. The overall goal of this project is to determine how chronic exposure to cigarette smoke affects extracellular matrix remodeling in the lung. Cigarette smoking is a major risk factor for the development of several non-neoplastic lung disorders, including chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and interstitial lung disease. Candace's research will focus on whether chronic exposure to tobacco smoke hinders normal tissue repair by altering the ability of cells to polymerize a fibronectin matrix. Her studies will provide insight into factors that regulate the deposition, conformation and physiologic properties of extracellular matrix fibronectin and determine if these factors are localized to lung tissue in response to cigarette smoke. Candace was born and raised in Rochester, NY. She graduated from the University of Rochester with a BS in Mechanical Engineering and completed a MS thesis in Biomedical Engineering at UR. She is currently in her fourth year as a PhD student in the Department of Biomedical Engineering, working under the direction of Dr. Denise C. Hocking.

SEAS Receives $30 Million Gift from University of Rochester Engineering Alumni, Edmund A. Hajim

Friday, October 17, 2008

Edmund A. Hajim, University of Rochester Chairman of the Board of Trustees and a 1958 engineering school graduate, announced his plans to give to the SEAS $30 million. The gift, which will be paid over several years, will provide scholarships for students with significant financial needs; it will also be put towards the endowment.

Read More: SEAS Receives $30 Million Gift from University of Rochester Engineering Alumni, Edmund A. Hajim

Nano Spin-Off Company Wins Business Plan Challenge

Monday, August 11, 2008

SiMPore, Inc., a spin-off company founded by engineers on River Campus, recently won the Golden Horseshoe Business Challenge, a $100,000 prize recognizing its business plan as the best in a region encompassing western New York and eastern Ontario. SiMPore also attracted $1.25 million in investments financed primarily by local Rochester high net worth individuals. In addition to VP of Life Sciences Tom Gaborski, (BME Ph.D. 2008), this venture involves interactions with numerous BME faculty members and students.

Laura Yanoso Scholl wins Award at the SBC 2008 meeting

Sunday, June 29, 2008

photo of Laura Yanoso Scholl

Laura Yanoso Scholl presenting her poster at the Summer Bioengineering Conference.

Laura Yanoso Scholl won the First Prize in the MS Student Poster Competition at the Summer Bioengineering Conference (June 25-29, 2008), Marco Island, FL, for her paper and poster entitled Evaluation of Poly-Lactic Acid/Beta-Tricalcium Phosphate Scaffolds as Segmental Bone Graft Substitutes.

BME Graduate students place in Mark Ain Business Model Workshop Series and Competition

Sunday, June 1, 2008

The Mark Ain Business Model Workshop Series and Competition provides aspiring student entrepreneurs at the University of Rochester an opportunity to attend a series of three workshops that cover the following topics: articulation of their concept, sizing up market dynamics, development of business and operational models, and exposure to startup implementation issues. At the conclusion of the workshops, student finalists present their concept, analysis, and recommended business model to a panel of distinguished alumni entrepreneurs and entrepreneurship professionals in a competition with a first-place cash prize of $10,000. The competition is made possible by support from Simon alumnus and entrepreneur Mark S. Ain '67, founder of Kronos Incorporated, the Chelmsford, Massachusetts-based market leader in the workforce management industry. In 2008, the 2nd and 3rd place prizes were awarded to interdisciplinary teams involving four BME graduate students.

Nature Photographic Exhibit by Babak & Anne Razavi

Friday, May 9, 2008

Babak Razavi is a trainee in the Medical Scientist Training Program pursuing an M.D. as well as a Ph.D. in Biomedical Engineering. His passion with photography began at a young age when his father taught him how to take pictures using a Canon AE-1 back in Iran. Anne Razavi worked as a medical physicist at the Wilmot Cancer Center and Department of Radiation Oncology. She trained at the Charité Hospital, Humboldt University of Berlin, Germany. She is now a product marketing manager with Siemens Medical Solutions. Babak and Anne both enjoy capturing a variety of themes including abstracts, nature, candids, weddings, and each other.

David Reynolds Wins Award at the 2007 TERMIS Meeting

Saturday, June 16, 2007

photo of David Reynolds and Dr. Awad

David Reynolds and Dr. Awad after winning the Ph.D. Student Competition.

David Reynolds won First Prize in the Ph.D. student competition at the Tissue Engineering & Regenerative Medicine International Society (TERMIS) meeting in Toronto (June 13-16, 2007) for his paper and poster entitled Novel Measurement of Bone Graft-to-Host Union Using CT Imaging: Implications for Biomechanical Strength. David competed with 250 student applicants and along with the honor of placing first he won a $1,000 cash prize.