New Issue of Opportunities to Explore
Friday, June 16, 2017
The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars
Transitioning into a Non-academic Career- Hosted by American Association for the Advancement of Science (Webinar)
Tuesday, June 20 | 12:00 pm – 1:00 pm | Online Webinar
Josh Henkin, PhD, Founder, Stem Career Services, LLC, will present on the skills and best practices for transitioning from an academic environment to one of many non-academic career paths. The workshop will introduce strategies for career planning, emphasizing an ongoing process for professional development throughout your career. For more information and to register, please click visit the presentation event site.Read More: New Issue of Opportunities to Explore
Steve N. Georas Named to New Parkes Professorship
Tuesday, June 13, 2017
Physician-scientist Steve N. Georas, M.D., professor of Medicine, Environmental Medicine, Microbiology and Immunology, was installed as the inaugural Parkes Family Professor June 5.
Walter and the late Carmina Parkes, and their children Susan, Tom and Linda, were driven to open the first asthma center in the region. They have been a steady force in the growth of the UR Medicine’s Mary M. Parkes Center for Asthma, Allergy and Pulmonary Care, working closely with center leaders, educators and scientists. The center is located on Red Creek Drive in Henrietta and serves as the leader for the diagnosis, treatment and research of acute asthma, allergies and other pulmonary diseases.
“It was our family’s dream to honor the memory of our daughter with the center. Now, establishing a professorship allows us to make it everlasting,” said Walter Parkes, chairman of O’Connell Electric Co. The family has committed $1.5 million to the University.
Mary Parkes was diagnosed with acute asthma as a young girl and went on to study nursing. She was an intensive care unit nurse before the lung disease progressed. She was hospitalized more than 50 times in the decades before her death in 1991. The center was established in 1995.
“We are so happy to be working with UR Medicine because it is always moving forward and we are proud to be a part of that energy,” said Susan Parkes McNally, executive vice president and treasurer of O’Connell Electric and member of the University of Rochester Medical Center Board as well as its Advancement, Facilities and Quality of Care subcommittees. “We look forward to what we can continue to do and achieve in providing care for people with chronic pulmonary issues.”
McNally is a steadfast supporter and has collaborated with the Junior Builders Exchange to organize an annual golf tournament for the past 21 years to support the Parkes Center. This year’s tournament will be held Sept. 7.
“URMC’s partnership with the Parkes family is essential to the success of clinical, research and education programs designed to improve asthma care,” said Mark Taubman, M.D., CEO of URMC and UR Medicine and dean of the School of Medicine and Dentistry. “Their support will serve as a lasting tribute and will further enable the innovative work being done in pulmonary diseases.”
“The establishment of this professorship by the Parkes family will be critical to advancing the Pulmonary Division’s clinical, educational and scientific efforts,” said Paul Levy, M.D., Chairman of the Department of Medicine and the Charles Ayrault Dewey Professor of Medicine. “The mantra that long-term relationships define so many aspects of our lives could not be more true than when I think of working closely with the Parkes family for nearly three decades. The early years of planning the Parkes Center, followed by renovations and the expansion of patient services were critical to the success of the center. Now the family has ‘raised the bar’ even higher with the establishment of an endowed professorship.”
Georas is a busy clinician-scientist who balances the patient care with leadership of a National Institutes of Health-funded laboratory at URMC.
He is part of the collaborative teams caring for patients in the Medical Intensive Care Units at UR Medicine’s Strong Memorial and Highland hospitals, as well at Mary M. Parkes Center for Asthma, Allergy and Pulmonary Care.
“Steve Georas’ clinical and scientific contributions are integral to the advancement of our programs and benefit our patients on a daily basis,” said Patricia Sime, M.D., Chief of Pulmonary Diseases and Critical Care and the C. Jane Davis and C. Robert Davis Distinguished Professor in Pulmonary Medicine. “Dr. Georas is an internationally recognized physician-scientist who has focused his career on advancing our understanding of the fundamental causes of asthma and translating his research to improve the care of patients with asthma.”
Georas is studying how the lung’s immune system responds to inhaled particles, allergens and viruses, and how this process breaks down in asthma leading to potentially dangerous immune responses that can cause allergic airway inflammation and difficulty breathing. He is also working to develop techniques to identify people who are at greater risk of developing life-threatening asthma and need intensive therapies.
“The support we’ve received from the Parkes family for our asthma research is invaluable and has allowed us to make steady progress toward new pathways for asthma treatment,” Georas said. He is an internationally recognized thought leader in asthma research, and has served on advisory committees to the U.S. Food and Drug Administration, National Institutes of Health and numerous professional societies. Later this year he will chair the NIH panel review for the PrecISE Asthma Network, which will establish the next generation of asthma centers developing personalized treatments for severe asthmatics.
A graduate of Brown University and its medical school, he completed an Internal Medicine internship and residency at Duke University Medical Center. After a fellowship in Pulmonary and Critical Care Medicine at Johns Hopkins University, he joined its faculty and conducted research into asthma and allergies. In 2006, Georas joined URMC and served as chief of the Division of Pulmonary & Critical Care Medicine until 2010. Georas has been honored for his teaching and mentorship of students, post-doctoral fellows and junior faculty.
He has published more than 85 research articles and chapters on asthma immunology and the care of patients with pulmonary diseases.
Talk on Environmental Hazards at Home
Tuesday, June 13, 2017
Cait Fallone of the University’s Environmental Health Sciences Center and Jennifer Becker of the Finger Lakes Children’s Environmental Health Center will present “Could Your Home Be Making You Sick? Learn How to Stay Safe” from 12:10 to 12:50 p.m. Thursday, June 15, at the Rochester Central Library’s Bausch and Lomb Building, 115 South Ave. The lecture is part of a community health education series “Got Health?” co-sponsored by the Center for Community Health and the Central Library. Parking is available in the Court Street garage.
Grant Helps Build Understanding of Environmental Health with Hands-on Science Kits
Monday, June 12, 2017
A University of Rochester start-up company, Science Take-Out, LLC, has been awarded a nearly $1 million, two-year grant from the National Institutes of Health to further develop a line of hands-on environmental health science kits for use in community settings. The kits will help teachers and community educators increase the public’s understanding of how the environment can affect their health.
The Small Business Technology Transfer (STTR) Grant from the National Institute of Environmental Health Sciences (NIEHS) at the NIH will support modification of Science Take-Out’s current line of environmental health education kits for broader use.
Since 2008, Science Take-Out kits have provided a convenient and cost-effective way for teachers to incorporate engaging environmental health science activities into their classrooms. Now the kits, which align with national and state science education standards, will undergo a second round of extensive field testing to ensure they are relevant and accessible to diverse community audiences.
“Educating students and the general public about the link between the environment and their health allows them to make informed decisions and change their behavior to protect themselves from environmental exposures,” said Dina Markowitz, Ph.D., professor of Environmental Medicine, director of UR’s Life Sciences Learning Center.
Markowitz and Katrina Korfmacher, Ph.D., associate professor of Environmental Medicine and director of the Community Outreach and Engagement Core (COEC) at URMC’s Environmental Health Science Center, partnered to develop and test eight current environmental health kits, which range from lessons on breast cancer to lead poisoning prevention.
With the new award Markowitz and Korfmacher will collaborate with environmental health community outreach professionals from the University of North Carolina at Chapel Hill COEC, the University of Texas Medical Branch COEC, and West Harlem Environmental Action to adapt the kits for use outside of the classroom.Read More: Grant Helps Build Understanding of Environmental Health with Hands-on Science Kits
New Issue of Opportunities to Explore
Thursday, June 8, 2017
The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars
Read More: New Issue of Opportunities to Explore
Pathology Research Day
Monday, June 12 | 8:00 am – 5:00 pm | Poster Session- Flaum Atrium & Presentations- Class if ’62 Auditorium
This year's event will take place on Monday, June 12, 2017 with a keynote speech by Perry J. Blackshear, MD, D. Phil, Deputy Chief of Signal Transduction Laboratory and Head of the Post-Transcriptional Gene Expression Group for the National Institute of Environmental Health Sciences. For a full schedule see Pathology Research Day Schedule. All presentations are free and open to the public.
Si Chen, Awarded Two-year American Heart Association Predoctoral Fellowship
Thursday, June 8, 2017
Si Chen, graduate student in the laboratory of Dr. Chen Yan was awarded a two-year American Heart Association predoctoral fellowship entitled, “The Role of PDE10A in Pathological Cardiac Remodeling and Dysfunction” beginning July 1, 2017.
Heart failure is a leading cause of death in the United States, and is associated with significant myocardial deterioration, including hypertrophy, fibrosis and cell death, as well as contractile dysfunction and ventricular arrhythmia. There is a high demand to identify novel therapeutic targets involved in pathological cardiac remodeling and dysfunction. The objective of this project is to investigate the regulation and function of the cyclic nucleotide phosphodiesterase 10A (PDE10A) isoform in the progression of cardiac remodeling and heart failure. PDE10A primarily hydrolyzes cAMP, and under normal conditions, displays enriched expression in the striatum of the brain. Our preliminary data demonstrate that PDE10A expression is upregulated in failing mouse and human hearts. Global deficiency of PDE10A attenuates global cardiac hypertrophy and fibrosis induced by chronic Ang II infusion. In vitro studies also indicate that PDE10A inhibitor treatment reduces cardiac myocyte hypertrophy and fibroblast activation. In the brain, PDE10A primarily regulates dopamine receptor (DR)-derived cAMP. Based on these facts, we hypothesize that PDE10A plays an essential role in cardiac hypertrophy, fibrosis, and dysfunction by antagonizing cAMP/cAMP-dependent protein kinase (PKA) signaling in myocytes and cAMP/exchange factor directly activated by cAMP (Epac) signaling in fibroblasts. To test our hypothesis we propose the following two aims:
- Aim1: Evaluate the role of PDE10A on pathological cardiac remodeling and dysfunction in vivo using genetic and pharmacological approaches.
- Aim2: Determine the roles and underlying mechanisms of PDE10A in the regulation of cardiac myocyte and fibroblast function in vitro.
Video of 3 Minute Thesis Event
Thursday, June 8, 2017
We have the video of the full event with all presentations fully captions and with the slides running in time with the videos.
3MT Presenters, Programs & Topics
Thesis presentations in order
- Stephanie Carpenter (Chemistry) - Solving the Mystery of Iron Chemistry
- Sarah Catheline (Pathways of Human Disease) - Inhibiting Inflammaging to Treat Osteoarthritis(OA)
- Scott Friedland (Genetics, Development & Stem Cells) - Pancreatic Cancer and the Tale of the Broken Librarian
- Claire McCarthy (Toxicology) - Investigating the Toxicological Effects of Dung Biomass Smoke Exposure
- Taylor Moon (Immunology, Microbiology and Virology) - The New Epidemic
- Thuy-Vy Nguyen (Social-Personality Psychology) - Solitude *Winner*
- Manisha Taya (Cellular & Molecular Pharmacology and Physiology) - Understanding Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Dependent Cancer From Bed-Side to Bench and Back Again
- Janelle Veazey (Immunology, Microbiology and Virology) - Role of Protein Kinase D in Epithelial Cells During Respiratory Infection
Full 3MT 2017 Event Video (CC)
New Issue of Opportunities to Explore
Friday, June 2, 2017
The new issue of opportunities to explore is out now, with details on awards, opportunities, professional development events and webinars
“Ask a Scientist” table this summer at The Brighton Farmers Market. The Brighton Farmers Market has offered to provide a table during the summer market which they are calling "Ask a Scientist." The goal is to capitalize on the energy from local teach-ins and the March for Science to provide educational outreach on an ongoing basis. The market takes place on Sundays from 9am - 1pm, May 14 - November 19. The GoogleDoc includes a sign-up for two-hour time slots throughout the summer. If you are interested in participating, please sign yourself up, and pass the link on to others who may be interested. Scientists from all backgrounds and levels are welcome and encouraged to participate. More details and information on this and other events can be found in the latest issue of OTE, See below to read more.Read More: New Issue of Opportunities to Explore
Pathology Graduate Student Wins Travel Award for Research Project
Wednesday, May 31, 2017
Second-year Pathology graduate student Madison Doolittle won second place in the School of Medicine and Dentistry’s graduate student poster competition on May 17.
Second-year Pathology graduate student Madison Doolittle won second place in the School of Medicine and Dentistry’s graduate student poster competition on May 17.
The annual event, hosted by the Graduate Student Society, includes entries from graduate students across disciplines as an opportunity to showcase their research in their respective fields.
Madison was the lead author the abstract titled, “Investigating the Role of Zbtb40 in the Genetic Regulation of Osteoporosis” in which he and fellow researchers examined the genetic determinants of bone mineral density used to diagnose osteoporosis.
He was awarded a $300 travel scholarship.
University Research Awards span a wide range of topics
Wednesday, May 31, 2017
The awards, originally called Provost’s Multidisciplinary Awards, are funded $250,000 every year by the president and matched by the schools for a total of $500,000 annually. They are designed to help researchers advance promising lines of research so that they can obtain external funding.Read More: University Research Awards span a wide range of topics
Study: A New Way to Slow Cancer Cell Growth
Friday, May 26, 2017
Cells grow and divide during the cell cycle
Cancer is an extremely complex disease, but its definition is quite simple: the abnormal and uncontrollable growth of cells. Researchers from the University of Rochester’s Center for RNA Biology have identified a new way to potentially slow the fast-growing cells that characterize all types of cancer. The findings, reported today in the journal Science and funded by the National Institutes of Health, were made in kidney and cervical cancer cells in the laboratory and are a long way from being applied in people. But, they could be the basis of a treatment option in the future, the authors said.
Cancer: The Cell Cycle Gone Wrong
All cells go through the “cell cycle,” a series of events that culminate in orderly cell growth and division. In cancer, the cell cycle is out of whack; cells divide without stopping and invade surrounding tissues.
Lynne Maquat, Ph.D.
Researchers identified a protein called Tudor-SN that is important in the “preparatory” phase of the cell cycle – the period when the cell gets ready to divide. When scientists eliminated this protein from cells, using the gene editing technology CRISPR-Cas9, cells took longer to gear up for division. The loss of Tudor-SN slowed the cell cycle.
“We know that Tudor-SN is more abundant in cancer cells than healthy cells, and our study suggests that targeting this protein could inhibit fast-growing cancer cells,” said Reyad A. Elbarbary, Ph.D., lead study author and research assistant professor in the Center for RNA Biology and the department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry.
Elbarbary, who works in the laboratory of senior study author Lynne E. Maquat, Ph.D., a world-renowned expert in RNA biology, adds that there are existing compounds that block Tudor-SN that could be good candidates for a possible therapy.
Putting the Brakes on Cell Growth
Maquat’s team discovered that Tudor-SN influences the cell cycle by controlling microRNAs, molecules that fine tune the expression of thousands of human genes.
When Tudor-SN is removed from human cells, the levels of dozens of microRNAs go up. Boosting the presence of microRNAs puts the brakes on genes that encourage cell growth. With these genes in the “off” position, the cell moves more slowly from the preparatory phase to the cell division phase.
“Because cancer cells have a faulty cell cycle, pursuing factors involved in the cell cycle is a promising avenue for cancer treatment,” noted Maquat, director of the Center for RNA Biology and the J. Lowell Orbison Endowed Chair and professor of Biochemistry and Biophysics.
Maquat, who also holds an appointment in the Wilmot Cancer Institute, and Elbarbary have filed a patent application for methods targeting Tudor-SN for the treatment and prevention of cancer. Research next steps include understanding how Tudor-SN works in concert with other molecules and proteins so that scientists can identify the most appropriate drugs to target it.
Keita Miyoshi, Ph.D., staff scientist in Maquat’s lab, served as lead study author with Elbarbary. Jason R. Myers and John M. Ashton, Ph.D. from the UR Genomics Research Center played an instrumental role in the study analysis.Read More: Study: A New Way to Slow Cancer Cell Growth
Slaughter Announces $524,000 Grant for Science Take-Out to Continue Environmental Health Education Initiative
Thursday, May 25, 2017
Congresswoman Louise Slaughter (NY-25) today announced a $524,883 federal award for Science Take-Out, a locally-based company that manufactures easy-to-use, hands-on science kits for students. This funding, administered by the Department of Human Health and Services’ (HHS) Small Business Technology Transfer (STTR) program, will expand on Science Take-Out’s successful STTR Phase I project that developed environmental health education kits for students in partnership with the University of Rochester’s Environmental Health Sciences Center.
“I’m so pleased to announce this federal funding for Science Take-Out to continue their important work educating kids and community members about science. At a time when science and fact are under siege, it is critical that organizations like this promote the building blocks of environmental education for our students. I’ve often said that Rochester is home to some of the brightest minds in the country and this is largely because of businesses like Science Take-Out, who help to inspire the next generation of researchers and environmental advocates with engaging, hands-on activities,” said Rep. Slaughter.
Currently, environmental health is typically covered minimally, if at all, in secondary school classrooms and there are also very few available hands-on activities that engage the general public in learning about concepts related to environmental health. Science Take-Out develops and manufactures innovative and easy-to-use hands-on science activity kits that are used in schools throughout the country. This new award will support Science Take-Out’s efforts to gather evidence on the impact of environmental health science kits on students’ learning and to modify the kits for use in diverse, community-based settings.
“Science Take-Out believes in the power of hands-on, experiential learning. That’s what our science kits do: provide students with the fun, easy-to-use tools they need to broaden their knowledge about science and health. We are a team of experienced science educators always looking for more ways to engage young students and this grant will go a long way in supporting that mission. Thank you, Congresswoman Slaughter, for your support of federal investments in research and science education,” said Dina Markowitz, president of Science Take-Out and professor of Environmental Medicine at the University of Rochester.
This funding expands Science Take-Out’s successful STTR Phase I project that developed and pilot-tested eight hands-on Science Take-Out kits on topics in environmental health science in partnership with the University of Rochester’s Environmental Health Sciences Center. These kits aid students in learning important health concepts such as: the biological effects of lead, sun and pesticide poisoning and health issues associated with antimicrobial agents found in consumer products.
Lowery Receives Vincent du Vigneaud Award at Commencement 2017
Wednesday, May 24, 2017
Rebecca Lowery and Edith Lord
Ania Majewska Speaking about Rebecca Lowery
Rebecca Lowery, Ph.D., a graduate of the laboratory of Dr. Ania Majewska, received the Vincent du Vigneaud Award at Commencement 2017 for her thesis titled “The Role of Microglia and Fractalkine Signaling in Experience-dependent Synaptic Plasticity”.
This award is conferred by the Office of Graduate Education at the School of Medicine and Dentistry to a graduating student from any program whose thesis is judged superior and unique in potential for stimulating and extending research in the field. The award is given in honor of Vincent du Vigneaud, (1901-1978) who received his Ph.D. in Biochemistry (formerly known as Vital Economics) in 1927 at the University of Rochester School of Medicine and Dentistry, studying on the sulfur component of insulin.
Papasergi-Scott, Taya, and Wang Win Awards at the GSS Annual Poster Session Competition
Tuesday, May 23, 2017
Congratulations to the following students who won awards at the Graduate Student Society Annual Poster Session Competition held on May 6, 2016.
Makaía M. Papasergi-Scott, working in the laboratories of Dr. Gregory G. Tall and Dr. Robert Freeman, was awarded 1st Place and received a $500 travel reward for her poster titled “Phosphorylation of Ga Chaperone Ric-8A Regulates its Function”.
Manisha Taya working in the laboratory of Dr. Stephen R. Hammes, and Xiaowen Wang working in the laboratory of Dr. Mark D. Noble, tied for 3rd place and received $100 travel grants for their posters titled “The Role of Estrogen and Glycoprotein-NMB in Lymphangioleiomyomatosis (LAM) Progression” and “Identifying c-Cbl as a Critical Point of Intervention in Acquired Tamoxifen Resistant Breast Cancer”, respectively.
Stoveken Receives Wallace O. Fenn Award at Commencement 2017
Tuesday, May 23, 2017
Hannah Stoveken, a graduate from the Laboratory of Dr. Gregory G. Tall, received the Wallace O. Fenn Award at Commencement 2017 for her thesis titled “Activation of Adhesion G Protein-coupled Receptors by a Tethered Agonist: Mechanism of Action and Pharmacological Modulation”.
The Wallace O. Fenn Award is given annually to a graduating student judged to have performed especially meritorious research and who presented a Ph.D. thesis suitable to honor the name of Dr. Fenn, a Professor of Physiology at the University of Rochester School of Medicine and Dentistry from 1924 to 1961.
Taya wins Knockout Rounds at ENDO 2017 and Finalist in UofR Three Minute Thesis (3MT®) Competition
Tuesday, May 23, 2017
Manisha Taya, graduate student in the Hammes Lab, won the People's Choice First Place Award in the Knockout Rounds competition at the annual ENDO 2017 conference, held April 1-4, for her presentation of her research on lymphangioleiomyomatosis. View a video featuring interviews with the winners.
Taya was also a finalist in The University of Rochester Three Minute Thesis (3MT®) Competition held on Thursday May 11, 2017. 3MT is an academic competition that challenges PhD students and postdoctoral appointees to describe their research within three minutes to a general audience.
Catheline Awarded in Three-Minute Thesis Competition
Monday, May 15, 2017
Congratulations to Sarah Catheline for winning the People’s Choice Award at the University of Rochester’s Three Minute Thesis public competition held on May 11 at URMC.
Sarah is a fourth-year graduate student in the Pathways of Human Disease Ph.D. program and works in the lab of Dr. Jennifer Jonason. Her presentation, “Inhibiting Inflammaging to Treat Osteoarthritis (OA),” was one of eight to be accepted into the final round.
This year marks the second annual Three Minute Thesis public competition at the University of Rochester, which encourages participants to share their research in simple language that's both persuasive and easy for the average person to understand.
The event is open to current Ph.D. and professional doctorate (research) candidates in or beyond their third year of study. It’s also open to postdoctoral researchers. Winners receive travel awards ranging from $250-750.
The event is sponsored by the School of Medicine and Dentistry Center for Professional Development, the School of Arts, Science and Engineering Graduate Studies Office, the Graduate Student Society, and Graduate Student Association.
Three Minute Thesis Awards:
- Judge’s Winner: Thuy-vy Nguyen (Runner Up: Scott Friedland)
- People's Choice Award: Sarah Catheline
- Stephanie Carpenter: Solving the Mystery of Iron Chemistry
- Scott Friedland: Pancreatic Cancer and the Tale of the Broken Librarian
- Sarah Catheline: Inhibiting Inflammaging to Treat Osteoarthritis (OA)?
- Claire McCarthy: Investigating the Toxicological Effects of Dung Biomass Smoke Exposure
- Taylor Moon: The New Epidemic
- Thuy-vy Nguyen: Solitude
- Manisha Taya: Understanding Lymphangioleiomyomatosis (LAM): The “Other” Steroid-Dependent Cancer From Bed-Side to Bench and Back Again
- Janelle Veazey: Role of Protein Kinase D in Epithelial Cells During Respiratory Infection
Scott Friedland takes 2nd place in the Three Minute Thesis (3MT) competition
Monday, May 15, 2017
On May 11th, 2017, Scott Friedland took 2nd place in the Three Minute Thesis (3MT) competition with his talk entitled, “Pancreatic Cancer and the Tale of the Broken Librarian. 3MT, created at The University of Queensland in Australia, is an effort to bring awareness to research and scientific communication, in which competitors have 3 minutes to get across the thrust of their thesis to a general audience. Scott is an MD/PhD student currently working in the lab of Dr. Aram Hezel in the Genetics, Development, and Stem Cells program. His research focuses on defining the role of ARID1A and the SWI/SNF complex in pancreatic cancer and development.Read More: Scott Friedland takes 2nd place in the Three Minute Thesis (3MT) competition
Interviewing Workshop a Success
Wednesday, May 10, 2017
The Interviewing Workshop: “Preparing for the Job Interview”, was another successful workshop. We had 11 participants from various programs throughout the School of Medicine and Dentistry participate in the interactive workshop. The workshop provided students and trainees information on how to prepare for various types of interview styles including phone, Skype, in-person and group. Participants gained knowledge on general, behavioral, and situational interview questions and then put what they learned into practice by answering various interview questions with a partner and among the larger group. In addition, we discussed how to prepare for a presentation that you may be asked to deliver during the interview and what things to do post interview to help show an employer your continued interest in the position.
- Understand how to prepare for a job interview
- Learn about the different types of interviews
- Gain an understanding of the various types of interview questions (general interview questions, behavioral, and situational)
- Practice how to successfully answer various types of questions in an interview situation
For upcoming event information, please visit the CPD websiteRead More: Interviewing Workshop a Success
New Opportunities to Explore Edition - May 8-12, 2017
Friday, May 5, 2017
A new issue of Opportunities to Explore
This issue of OTE contains this weeks news on scholarships, a job interview workshop and the final of the 3 minute thesis competition
This issue also contains upcoming event information:
- Graduate women in science seminar featuring guest speaker Dr. Jane Skok, speaking on career re-entry
- The 4th annual alumni event
- Graduate Student Society (GSS) Poster Session
- URBEST Career Story Q & A: Elizabeth Schiavoni, MS
- University of Rochester Toastmasters Club guest day event
- CPD Sponsored Event: Qualifying Exam Preparation and Writing Workshop
- CPD and URBEST Sponsored Event: Lead with Your Top 5: A StengthsQuest Event
Volunteer Opportunities in Science
Relevant ReadsRead More: New Opportunities to Explore Edition - May 8-12, 2017
Congrats to Gianluca Di Maria on the Winning an Award at the 2017 Neuro Film Festival
Wednesday, April 26, 2017
Congrats to Halterman Lab Medical Student Intern, Giancarlo DiMaria for his Neuroscience Is…™ Rewarding
winning video, “The Brain Scientist: Neuroscience is Rewarding.” Following a neurologist in the clinic and a neuroscientist in the lab, this video highlights the challenging but rewarding nature of a career in neuroscience.
GDSC Students attend the March for Science
Tuesday, April 25, 2017
Students from the Genetics Program attended The Rochester March for Science on Saturday April 22
Fanju Meng (Biteau Lab), Sreejith (Biteau Lab), Emily Wexler (Portman Lab),
Sebastian Rojas Villa (Biteau Lab), Robert Hoff (Bohmann Lab), Andrew Allbee (Biteau Lab)
2017 Curtis Award
Monday, April 24, 2017
Neuroscience Graduate Program student Jessica Hogestyn, a student in the Mayer-Pröschel Lab, has been selected as one of the winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. Her nomination material exemplified her ability as an outstanding educator with bright future.
BMB, BSCB Students Win 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student
Saturday, April 1, 2017
BMB and BSCB graduate students, Lauren Benoodt, Tyler Couch, and Lisa Houston have been selected as joint winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. The students will be presented with a certificate, as well as checks of $700 for each. The three of them were TA’s for IND 408 (Advanced Biochemistry) in the Fall of 2016.
The Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student was established to recognize graduate students who advance the teaching mission of the University by providing highly skilled and innovative undergraduate instruction.
The strongest nominations show innovation in teaching and a positive impact on the learning of undergraduates.
Congratulations Lauren, Tyler, and Lisa!
Paula Alio Awarded J. William Fulbright Scholarship
Monday, March 27, 2017
Paula Alio, PhD, Assistant Professor of Public Health Sciences, has been awarded the J. William Fulbright Scholarship grant to study HIV among women (sex workers) in Niger.
Monique Mendes Serves as Judge at STEP UP to Medicine Poster Session
Friday, March 17, 2017
The Regional Science and Technology Entry Program (STEP UP) to Medicine conference was hosted by the University of Rochester on March 4th, 2017. NGP student, Monique Mendes was invited to serve as a judge at the poster session during the event based on her earlier involvement with that Program. Back in fall 2016, Monique and the Pre-doctoral Organization for Neurosciences (PONs), was invited to meet with the STEP UP to MEDICINE participants to discuss the brain and to share their neuroscientific research experiences. STEP UP to MEDICINE is a state funded program intended to help gifted and motivated high school students from economically disadvantaged backgrounds into undergraduate and graduate Science and Technology programs across the state of New York. On March 4th, the University of Rochester hosted STEP UP to Medicine conference attended by 15 statewide STEP programs representing 10 students each. The high school students had a chance to meet with their peers from other institutions, the UR physicians, technical staff, medical, and graduate students. Read More: Monique Mendes Serves as Judge at STEP UP to Medicine Poster Session
Rahman Receives Senior Toxicologist Award From The Society of Toxicology
Tuesday, March 14, 2017
Irfan Rahman, Ph.D., Professor of Environmental Medicine, has been awarded a Senior Toxicologist Award by the Society of Toxicology - Associations of Scientists of Indian Origin. The award was presented to Dr. Rahman in the presence of many Society of Toxicology (SOT) meeting attendees as well as several NIEHS officials.
He received the award at the SOT 56th Annual Meeting and ToxExpo in Baltimore, MD on March 13th. This year’s meeting, like its predecessors, was designed to provide members with access to cutting-edge science, networking opportunities, and career development resources through its various events and activities:
- 160+ Scientific Sessions, covering diverse topics such as age- dependent neuroimmunotoxicological effects, cardiopulmonary consequences of gestational toxicant exposure, and novel in vitro and in silico platforms, among dozens of others
- 50+ receptions and social events hosted by SOT Regional Chapters, Special Interest Groups, Specialty Sections, Committees, and other toxicology-related organizations
- 13 Continuing Education courses and other education opportunities
- ToxExpo, featuring more than 330 exhibitors providing products, services, and technology created to benefit the toxicology community
Congratulations Dr. Rahman!
Hocking and Roy Receive Patent
Wednesday, February 22, 2017
The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (U.S. Patent No. 9,572,869; awarded February 21, 2017) has recently been assigned to the UR with inventors Denise Hocking, Ph.D. and Daniel Roy, Ph.D. (BME B.S.‘06, Ph.D.‘12). The patent relates to the use of recombinant fibronectin-based peptides for wound healing and tissue regeneration applications. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Topical application of fibronectin matrix mimetic peptides to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization.
Denise Hocking, PhD is a Professor of Pharmacology and Physiology and of Biomedical Engineering. Daniel Roy is a Scientist at KeraNetics, LLC, a biotechnology company located in Winston-Salem, North Carolina that develops keratin-based biomaterials for wound healing applications.
Scott Steele selected to serve on the Food and Drug Administration's (FDA) Science Board
Monday, February 13, 2017
Scott Steele, PhD, Director of the CTSI Regulatory Science Core has been selected to serve on the Food and Drug Administration's (FDA) Science Board. The Board provides advice to the Commissioner and other FDA offcials, exploring issues from gene editing or regulation of opioids to food safety, and aims to help the FDA keep pace with technical and scientific developments.Read More: Scott Steele selected to serve on the Food and Drug Administration's (FDA) Science Board
Maquat Receives Lifetime Achievement Award in Science from International RNA Society
Tuesday, February 7, 2017
Lynne E. Maquat, Ph.D. has spent her career unraveling what happens in our cells during disease, making seminal contributions to our understanding of RNA’s role in sickness and in health. She’s also committed countless hours to mentoring the next generation of researchers and advocating for young women in the sciences. For these exceptional efforts, she’s receiving the 2017 Lifetime Achievement Award in Science from the international RNA Society.
The J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry, Maquat began her professional career studying inherited anemias. She discovered a quality control process that blocks the creation of toxic proteins that cause disease. Known as nonsense-mediated mRNA decay or NMD, this process plays a part in one third of all inherited diseases, such as cystic fibrosis and muscular dystrophy, and one third of all acquired diseases, including a number of cancers.
“This award recognizes Lynne’s pioneering contributions to understanding the mechanisms of RNA, as well as her outstanding leadership, support and commitment to our field, including her role as a model for new generations of scientists,” said Juan Valcarcel Juarez, current president of the RNA Society, who works at the Centre for Genomic Regulation in Barcelona, Spain.
James McSwiggen, CEO of the RNA Society, added, “I can’t imagine a more appropriate choice of awardee.”Read More: Maquat Receives Lifetime Achievement Award in Science from International RNA Society
Scientists develop new flu vaccines for dogs
Monday, January 30, 2017
Scientists at the University of Rochester School of Medicine and Dentistry have developed, for the first time, two new vaccines for canine influenza. This research is not only important for improving the health of our furry friends, but for keeping us safe, too. Dogs that have been infected with multiple influenza viruses have the potential to act as "mixing vessels" and generate new flu strains that could infect people. This hasn't happened yet, but experts say it's possible.
Today, veterinarians use vaccines that include inactivated or killed flu virus, but experts say they provide short-term, limited protection. Scientists led by Luis Martinez-Sobrido, Ph.D., associate professor in the department of Microbiology and Immunology created two "live-attenuated" vaccines against H3N8 canine influenza virus, which is currently circulating in dogs in the U.S. Past research shows that live-attenuated vaccines, made from live flu virus that is dampened down so that it doesn't cause the flu, provide better immune responses and longer periods of protection.Read More: Scientists develop new flu vaccines for dogs
URMC Drug Extends Effectiveness of HIV Therapy
Monday, January 30, 2017
Major Step toward Longer-Lasting HIV Treatment
A drug developed at the University of Rochester Medical Center extends the effectiveness of multiple HIV therapies by unleashing a cell’s own protective machinery on the virus. The finding, published today in the Journal of Clinical Investigation, is an important step toward the creation of long-acting HIV drugs that could be administered once or twice per year, in contrast to current HIV treatments that must be taken daily.
The drug, called URMC-099, was developed in the laboratory of UR scientist Harris A. (“Handy”) Gelbard, M.D., Ph.D. When combined with “nanoformulated” versions of two commonly used anti-HIV drugs (also called antiretroviral drugs), URMC-099 lifts the brakes on a process called autophagy.
Normally, autophagy allows cells to get rid of intracellular “trash,” including invading viruses. In HIV infection, the virus prevents cells from turning on autophagy; one of the many tricks it uses to survive. When the brake on autophagy is lifted, cells are able to digest any virus that remains after treatment with antiretroviral therapy, leaving cells free of virus for extended periods of time.
Harris A. (“Handy”) Gelbard, M.D., Ph.D.
“This study shows that URMC-099 has the potential to reduce the frequency of HIV therapy, which would eliminate the burden of daily treatment, greatly increase compliance and help people better manage the disease,” said Gelbard, professor and director of UR’s Center for Neural Development and Disease, who has studied HIV/AIDS for the past 25 years. The finding builds on previous research that Gelbard conducted with Howard E. Gendelman, M.D., professor and chair of the Department of Pharmacology/Experimental Neuroscience at the University of Nebraska Medical Center.Read More: URMC Drug Extends Effectiveness of HIV Therapy
AAMC Taps URMC for National Community Health and Equity Initiative
Thursday, January 12, 2017
The University of Rochester Medical Center is one of only eight institutions chosen by the Association of American Medical Colleges (AAMC) to join an effort to improve health equity and the health of communities nationwide.Read More: AAMC Taps URMC for National Community Health and Equity Initiative
Deborah Ossip, PhD, Elected President of the Society for Research on Nicotine and Tobacco.
Thursday, January 12, 2017
Deborah J. Ossip, Ph.D., professor of Public Health Sciences and Oncology, has been elected 2016 president of the Society for Research on Nicotine and Tobacco (SRNT). The international society coordinates and advances research related to nicotine and tobacco from molecular to societal levels, and it publishes the journal Nicotine & Tobacco Research.Read More: Deborah Ossip, PhD, Elected President of the Society for Research on Nicotine and Tobacco.
Todd Jusko, PhD awarded a one year research contract from the Centers for Disease Control and Prevention
Sunday, January 1, 2017
Todd Jusko, PhD, Assistant Professor of Epidemiology, was awarded a one year research contract from the Centers for Disease Control and Prevention. The overall objective of the project is to examine the relationship between in utero and postnatal blood lead concentrations and children's immune system function.
Rahman Article Chosen as One of URMC's Top 10 News Stories of 2016
Saturday, December 31, 2016
Irfan Rahman's study, published in Oncotarget in November, has been chosen by the URMC as one of the top news stories of 2016.
The study is the first-ever showing that E-cigarettes cause damage to gum tissue. Rahman's research suggests that electronic cigarettes are as equally damaging to gums and teeth as conventional cigarettes.Read More: Rahman Article Chosen as One of URMC's Top 10 News Stories of 2016
GDSC Student to join the Steven’s Laboratory at Harvard Medical
Tuesday, December 27, 2016
Nicole Scott-Hewett, a recent graduate of the GDSC program will be joining Beth Steven’s laboratory at the Boston Children's Hospital F.M. Kirby Neurobiology Center. There Nicole will be involved in projects related to understanding mechanisms of complement and microglia-mediated pruning in development and in disease models. With her paper in this month’s issue of PLoS Biology on lysosomal dysfunction, Nicole leaves us with a fanfare. We wish her all the best for her new beginnings in Boston!
Repurposed drugs may offer improved treatments for fatal genetic disorders
Wednesday, December 21, 2016
Department of Biomedical Genetics researchers believe they have identified a new means of treating some of the most severe genetic diseases of childhood, according to a new study in PLOS Biology. The diseases, called lysosomal storage disorders (LSDs), are caused by disruptions in the functioning of the stomach of the cell, known as the lysosome. LSDs include Krabbe disease, Gaucher disease , metachromatic leukodystrophy and about 40 related conditions. In their most aggressive forms, they cause death of affected children within a few years after birth.
The research was spear-headed by Nicole Scott-Hewett and Chris Folts, two recent graduates of the program in Genetics, Development and Stem Cells. Led by the article's corresponding author Mark Noble, Ph.D., the team discovered for the first time how specific toxic waste products that accumulate in LSDs cause multiple dysfunctions in affected cells. They also found that several drugs already approved for other uses have the unexpected ability of overcoming the cellular toxic build-up, providing new opportunities for treatment. Key to this discovery was the finding that these drugs can help restore normal acidification of the lysosome.
In a mouse model of Krabbe disease (one of the most severe LSDs), Drs. Folts and Scott-Hewett found that their lead study drug, colforsin, increased survival as effectively as in studies where disease-causing mutations were corrected by gene therapy. Colforsin is approved in Japan to treat cardiac disease, which provides information to investigators about its use in humans.
Increased survival in mice occurred even though treatment was started later than is necessary for gene therapy. The research treatment also decreased damage to the brain and improved the quality of life in the diseased mice. All of these outcomes are critical goals in the treatment of children with Krabbe disease or related illnesses, said Noble, who is the Martha M. Freeman, M.D., Professor in Biomedical Genetics at URMC.
"One of the great challenges in these diseases is that they are both rare and come in many different varieties, and advances have tended to focus on single diseases," Noble said. "In contrast, our findings suggest our treatments will be relevant to multiple disorders. Also, we saw benefits of our treatment even without needing to correct the underlying genetic defects. That gives us great hope that we could combine our treatments with other candidate approaches to gain additional benefits."
If the results can be translated into humans, Noble said, the repurposed drugs might improve the quality of life for afflicted children while more difficult experimental genetic treatments are pursued. The complete study can be found at: PLoS BiologyRead More: Repurposed drugs may offer improved treatments for fatal genetic disorders
Meng Wang, a former graduate student in the laboratory of Dr. Bohmann, has been named a Howard Hughes Medical Institute (HHMI) Faculty Scholar
Tuesday, December 20, 2016
Meng Weng, PhD
Dr. Meng Wang a former graduate student in the laboratory of Dr. Bohmann, has been named a Howard Hughes Medical Institute (HHMI) Faculty Scholar, a grant awarded to outstanding young scientists and researchers who have made impressive accomplishments and have a bright future in making groundbreaking contributions.
Dr. Wang is currently an associate professor at Baylor College of Medicine, where she studies the influence of endocrine and metabolic functions on aging, using C. elegans as a model system.
Research Led by Hucky Land Points to Prostate Cancer Tool
Tuesday, December 20, 2016
Researchers from Wilmot Cancer Institute and Roswell Park Cancer Institute in Buffalo reported in the journal Oncotarget that they have discovered a possible new tool for predicting whether prostate cancer will reoccur following surgery based on the expression patterns of four genes.
The Wilmot/Roswell Park tool was able to predict recurrence, based on human tissue samples and known patient outcomes, with 83 percent accuracy. Currently the only other way to estimate tumor aggressiveness is with a Gleason score, a grading system for prostate tumors that has limited power in most cases, researchers said.
Some prostate cancers grow very slowly, and when the disease is detected early, the five-year survival rates are nearly 100 percent. However, some men are diagnosed with more aggressive localized disease and, even after having a radical prostatectomy, cancer will return in one-third of patients.
“Our study sought to improve upon the prediction tools used in these types of cases so that oncologists would know with more certainty when to recommend additional treatment, such as radiotherapy, immediately after surgery,” said Hucky Land, Ph.D., director of research at Wilmot and the Robert and Dorothy Markin Chair of the Department of Biomedical Genetics, who led the research. (Most patients receive no further treatment after surgery.)
Earlier, Land’s lab discovered a large group of non-mutated genes that are actively involved in cancer development. After analyzing expression of this gene set in frozen prostate cancer tissue samples, researchers discovered the four-gene signature, which was expressed differently in prostate cancer that later returned. Justin Komisarof, an M.D./Ph.D. student in the Land lab, developed the various algorithms and methods to evaluate the gene signature. The research team concluded that their tool outperformed other scientific methods, and they have applied for a U.S. patent.
The National Institutes of Health and Wilmot Cancer Institute/Roswell Park Cancer Institute Collaboration Pilot Funds supported the research. Chief collaborators from Roswell Park include Carl Morrison, M.D., executive director of the Center for Personalized Medicine, and James Mohler, M.D., associate director and senior vice president for translational research at Roswell.
Read More: Research Led by Hucky Land Points to Prostate Cancer Tool
Jimmy Zhang, Awarded Two-year American Heart Association Predoctoral Fellowship
Friday, December 16, 2016
Jimmy Zhang, graduate student in the laboratory of Dr. Paul Brookes was awarded a two-year American Heart Association predoctoral fellowship entitled,
“The Development of Novel Acute Myocardial Infarction Therapeutics Using Metabolomics and High-Throughput Screening” beginning January 1, 2017.
Paradoxically, current AMI therapies have the common goal of promoting reperfusion and, in doing so, trigger events that lead to cell death. As a result, there is a need for new therapeutics that limit reperfusion-induced injury.
Many of the pathologic cellular events of reperfusion-induced injury can be attributed to maladaptive metabolic remodeling. One particular metabolite of interest is succinate, which accumulates during ischemia. Upon reperfusion, succinate is consumed in the electron transport chain by Complex II, generating reactive oxygen species at Complex I. This reverse electron transport (RET) appears to be a major contributor to IR injury. Yet, despite the relevance of RET to IR injury, the pathway of succinate accumulation has yet to be elucidated. Additionally, succinate accumulation during ischemia might contribute to the generation of the mitochondrial membrane potential by permitting Complex I activity. This membrane potential can then be used for functions such as membrane transport and maintenance of redox status.
In our preliminary data, nornicotine was identified as a potentially cardioprotective candidate, and was shown to inhibit Complex I activity. Inhibition of RET could be the mechanism of protection by nornicotine. Using high-throughput screening and metabolomic approaches, this project will determine whether inhibition of RET is a rapid metabolic adaptation that is conserved across cardioprotective strategies (nornicotine treatment, ischemic preconditioning, and ischemic postconditioning). Finally, the pathway and function of succinate accumulation will be investigated by measuring membrane potential and redox status in isolated mitochondria.
Overall, this project aims to investigate RET in IR injury with the goal of developing novel therapeutics for AMI.
Dr. Robert Block awarded a 2-year research grant from the international Atherosclerosis Society and Pfizer Pharmaceutical Corporation
Thursday, December 15, 2016
Robert Block, MD, MPH, was awarded a 2-year research grant from the international Atherosclerosis Society and Pfizer Pharmaceutical Corporation. The overall goal is to partner with patients with familial hypercholesterolemia (a genetic disease that causes very premature heart attacks and strokes) and physicians in order to build and test educational/motivational information about this disease within the University of Rochester's electronic health record.
Researchers Identify Brain Region as Possible Target for Dementia Prevention
Tuesday, December 13, 2016
A University of Rochester study has found that older adults with excellent memories have more efficient connections between specific areas of the brain — findings that could hold promise for the prevention of dementia and cognitive decline.
Although researchers have historically viewed memory deterioration as an inevitable part of the aging process, a small group of older adults — called “supernormals” — are able to maintain their memory capacities much better than their peers. Feng (Vankee) Lin, PhD, an assistant professor in the University of Rochester School of Nursing, is spearheading a new approach to the study of Alzheimer’s disease by exploring what can be learned from these individuals.
In a study on the topic published in Cortex, an international journal devoted to the study of cognition and the relationship between the nervous system and mental processes, Lin and her team explored differences in brain function among three groups of older adults: supernormals, who were defined as having higher than average memory scores for their age, older adults diagnosed with amnestic mild cognitive impairment who are at high risk for developing Alzheimer’s disease, and a healthy control group. The study is the first to compare the brain function of supernormals to those who are at risk for developing Alzheimer’s.Read More: Researchers Identify Brain Region as Possible Target for Dementia Prevention
Mitchell O'Connell Lab To Open
Monday, December 12, 2016
Current Postdoctoral Berkeley Fellow, Mitchell O'Connell, Ph.D. is set to open his new lab in April 2017, in the department of Biochemistry & Biophysics, at URMC. Currently Mitch is working in Jennifer Doudna's lab and his research aims to understand the mechanisms of RNA-mediated gene regulation through the development of new RNA-targeting tools based on CRISPR/Cas technology.
University Research Award helps team explore regeneration in a critical layer of the cornea
Friday, December 9, 2016
The structure of the cornea.
(Keratomania.com eye diagram by
Chabacano,via Wikimedia Commons.)
On the backside of the cornea is a single layer of cells that plays an all-important role, maintaining just the right fluid balance to keep the cornea transparent so that light can enter the eye. Until recently, it was believed this layer, called the corneal endothelium, is incapable of replacing its damaged cells. As more cells become damaged, the cornea becomes opaque, leading to loss of vision and, ultimately, to as many as 30,000 endothelium transplants a year in the United States alone.
A team of University researchers is exploring the possibility that stem cells on the outer edges of the cornea, given the right stimulation, can migrate into the endothelium to replace damaged cells. (Undifferentiated stem cells develop into specialized cells.) The work raises the possibility of restoring vision without the need for transplants.
The team is led by Amy Kiernan, associate professor of ophthalmology, and includes Jannick Rolland, the Brian J. Thompson Professor of Optical Engineering; Patrice Tankam, a senior scientist in the Center for Visual Science; Changsik Yoon, a graduate student in Rolland’s lab; Rebecca Rausch, a graduate student in Kiernan’s lab; and Holly Hindman, former associate professor of ophthalmology, now in private practice but still consulting on the project. They are supported with a $75,000 University Research Award. The URA program is designed to help researchers develop preliminary data or proof of concept needed to leverage larger federal or foundation awards to carry a promising project to completion.
There have been tantalizing clinical hints that the corneal endothelium may have regenerative capabilities, Kiernan says. For example, there have been cases in which endothelial transplants failed to engraft, but the cornea cleared up anyway, with regeneration of the endothelium occurring on its own. “So it seems that if something is done that stimulates a progenitor or stem cell population, most likely those in the periphery of the cornea, there is some regenerative capacity in the endothelium – just based on clinical studies,” Kiernan says.
Her team will attempt to identify the potential stem cells that might be stimulated to migrate to the endothelium to repair damage. They will use mouse models from Kiernan’s lab in which adult stem cells can be permanently tagged with fluorescent biomarkers and tracked even after they differentiate into other cells. The identification and tracking of those cells will be done by refining a novel imaging approach developed in Rolland’s lab. Called Gabor domain optical coherence microscopy, the technology allows rapid, noninvasive imaging of cellular structures beneath the surface of the skin or within the human eye – in greater detail than traditional imaging with optical coherence tomography.
“Think of it as a high-definition, volumetric imaging,” Rolland says. “But we also want to know what kind of cells we are looking at, so we are integrating fluorescence imaging with the high-definition volumetric microscopy so we can do both.” The team represents a combination of pertinent expertise: cell development and regeneration (Kiernan and Rausch), imaging (Rolland, Tankam, and Yoon), and the biological basis for corneal and ocular surface diseases in humans (Hindman). The University Research Award funding is helping support graduate students and technicians working on the project, and the cost of mice and supplies. “Pilot funding like this is so important, especially with NIH grants shrinking,” Kiernan says.
“It’s really helpful to be able to bridge this kind of interdisciplinary effort,” says Rolland. “You need to work together a little bit to understand the challenges involved and what you need to do to secure preliminary data, to show we have a pathway.
“It takes time to get data, so even a small grant that provides a bridge for a year or two can make a huge difference.”
Nina Schor to Step Down as Children's Hospital Pediatrician-in-Chief
Wednesday, December 7, 2016
Nina Schor, M.D., Ph.D., William H. Eilinger Chair of Pediatrics at the University of Rochester Medical Center (URMC), will step down as chair in June 2017. Schor served 11 years as pediatrician-in-chief at UR Medicine’s Golisano Children’s Hospital, and under her leadership, the Department of Pediatrics fulfilled a decades-long dream of building a standalone children’s hospital in Rochester; the new facility opened its doors to patients in July 2015. "I don’t want to downplay the significance of the new hospital, but it’s really what we do inside of it and because of it that’s so important,” said Schor. “I look at the academic physicians and physician scientists who came to Rochester with just a dream and a fire in their belly and how they’ve now brought those dreams to fruition — that’s what I’m most proud of.”
The Department of Pediatrics grew from 110 faculty members to over 170 during Schor’s tenure, creating new divisions in palliative care, sleep medicine, allergy, and hospitalist medicine. Research centers focused on premature infants, translational molecular programs, and red blood cell development also developed under Schor’s leadership.
“Not only was the new hospital built under Nina’s leadership, but she truly championed the project, ensuring that every detail was designed with patients and families in mind,” said Mark Taubman, M.D., URMC CEO and Dean of the School of Medicine and Dentistry. “She has been the face of the children’s hospital and inspired trust in our families, physicians, and donors at a time when we very much needed the community’s support.”Read More: Nina Schor to Step Down as Children's Hospital Pediatrician-in-Chief
Study Challenges Autism Brain Response Theory
Tuesday, December 6, 2016
A new study challenges the hypothesis that nerve cells in the brains of individuals with Autism Spectrum Disorders do not reliably and consistently respond to external stimuli. “Our findings show there is no measurable variation in how individuals with autism respond to repeated visual and tactile stimuli,” says senior author John Foxe, the Kilian J. and Caroline F. Schmitt Professor in Neuroscience.Read More: Study Challenges Autism Brain Response Theory
New Biophysical Research Service Available
Friday, December 2, 2016
The University has purchased a J-1100 circular dichroism (CD) spectrometer from JASCO Inc. The shared-use instrument will be housed and maintained as part of the Structural Biology and Biophysics facility. Manager Jermaine Jenkins will maintain the instrument, as well as manage user time, train users, and assist with data collection and analysis as needed. Email Jermaine Jenkins, Ph.D. to plan your experiments. Read More: New Biophysical Research Service Available
Helena Temkin-Greener, PhD was awarded a two-year research grant from the Donaghue Foundation
Thursday, December 1, 2016
Helena Temkin-Greener, PhD was awarded a two-year research grant from the Donaghue Foundation. The overall goal of the research project is to develop process and outcome-based measures of care quality for nursing home residents with mental health and behavioral disorders, and to explain variations in these measures across facilities and regions/states. Locally, findings will provide a benchmark performance measure for nursing homes participating in the NYS Delivery System Reform Incentive Payment (DSRIP) Program.
NIH Pre-Doctoral Fellowship Award
Tuesday, November 29, 2016
Matt Cavanaugh, a fifth year Neuroscience Graduate Program student in Dr. Krystel Huxlin’s lab was awarded an NIH Individual Pre-doctoral Fellowship from the National Eye Institute for his project entitled: Properties of training-induced visual recovery in cortical blindness (2016-2019).
Brain training video games help low-vision kids see better
Monday, November 28, 2016
Studies going back several years have shown that playing action video games (AVG) can help improve visual acuity. A new study by vision scientists at the University of Rochester and Vanderbilt University found that children with poor vision see vast improvement in their peripheral vision after only eight hours of training via kid-friendly video games. Most surprising to the scientists was the range of visual gains the children made, and that the gains were quickly acquired and stable when tested a year later.
“Children who have profound visual deficits often expend a disproportionate amount of effort trying to see straight ahead, and as a consequence they neglect their peripheral vision,” said Duje Tadin, associate professor of brain and cognitive sciences at Rochester. “This is problematic because visual periphery—which plays a critical role in mobility and other key visual functions—is often less affected by visual impairments.”
“We know that action video games (AVG) can improve visual perception, so we isolated the AVG components that we thought would have the strongest effect on perception and devised a kid-friendly game that compels players to pay attention to the entire visual field, not just where their vision is most impaired,” said Tadin, who is also a professor in the Center for Visual Science. “As a result, we’ve seen up to 50 percent improvement in visual perception tasks.”Read More: Brain training video games help low-vision kids see better
Children’s Hospital Pediatrician-in-Chief Named Fellow of the AAAS
Monday, November 21, 2016
Nina Schor, M.D., Ph.D., William H. Eilinger Chair of Pediatrics and the pediatrician-in-chief at UR Medicine’s Golisano Children’s Hospital, has been named a Fellow of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society.
AAAS, which will publish the announcement on Nov. 25 in its journal Science, selects Fellows based on their scientifically and socially distinguished efforts to advance science or its applications. Schor has spent much of her career investigating neuroblastoma — which is among the most common childhood cancers — and was recognized for “her distinguished contributions to developmental neuroscience and neuropharmacology, particularly using molecular neuroscientific discoveries to design innovative therapies for tumors of the developing nervous system.”Read More: Children’s Hospital Pediatrician-in-Chief Named Fellow of the AAAS
‘Antisense’ compounds offer new weapon against influenza A
Thursday, November 17, 2016
Challenging a long-held convention, University researchers have shown they can inhibit the influenza A virus by targeting its genomic RNA with “antisense” compounds.
Their findings, highlighted on the cover of Nucleic Acid Therapeutics, offer scientists a new way to attack an increasingly drug-resistant pathogen that causes an estimated 250,000 to 500,000 deaths a year.
“Antisense” compounds are synthesized with nucleotides, the building blocks of nucleic acid, often shown as various combinations of A, U, G and C. When the compounds – called antisense oligonucleotides (ASOs) – bind to the targeted genomic RNA, they block its ability to replicate.
The collaboration, involving the labs of Douglas Turner, professor of chemistry; Luis Martinez-Sobrido, associate professor of microbiology and immunology; and two researchers in Poland, reported that “antisense” compounds targeting one of the virus’ eight genomic RNA segments caused a five- to 25-fold reduction of influenza A virus in cell cultures.
“That’s a big difference,” Martinez-Sobrido says. “When mice are infected with 10,000 viruses, they all die. However, with 25 times less virus, all animals can survive infection and they don’t even develop symptoms.”
Read More: ‘Antisense’ compounds offer new weapon against influenza A
Wilmot Co-directors Honored with Davey Award
Tuesday, November 15, 2016
Hartmut “Hucky” Land, Ph.D. (left) and David C. Linehan, M.D.
Wilmot Cancer Institute’s co-directors Hartmut “Hucky” Land, Ph.D., and David C. Linehan, M.D., were recognized recently with the Davey Award, an honor bestowed on University of Rochester faculty members who have made outstanding contributions to cancer research.
They received their awards at the 21st annual Wilmot Scientific Symposium Nov. 10. The award for Land, who organizes the annual symposium, was a surprise orchestrated by Jonathan W. Friedberg, M.D., M.M.Sc., director of Wilmot Cancer Institute.
At the symposium, Land presented the planned Davey Award to Linehan, who is also Wilmot’s director of clinical operations and the Seymour I. Schwartz Professor and Chairman of Surgery. Linehan was recognized for his work studying the role of the tumor microenvironment in promoting treatment resistance in pancreatic cancer.
Before his lecture, Linehan presented Land the surprise award with a recorded video message from Friedberg. Land, who is also Wilmot’s director of research and the Robert and Dorothy Markin Professor of Biomedical Genetics, was recognized for his body of work and for his work studying the genetic programs that control all of cancer’s worst shared features — such as a cancer cell’s ability to quickly divide and survive despite aggressive treatment.
Repurposed Drug May Offer Diagnosis, Treatment for Traumatic Nerve Damage
Monday, November 14, 2016
Researchers at the University of Rochester Medical Center believe they have identified a new means of enhancing the body’s ability to repair its own cells, which they hope will lead to better diagnosis and treatment of traumatic nerve injuries, like those sustained in car accidents, sports injuries, or in combat. In a study published today, the team showed that a drug previously approved for other purposes can ‘wake up’ damaged peripheral nerves and speed repair and functional recovery after injury.
The study appearing in EMBO Molecular Medicine, demonstrates for the first time that 4-aminopyridine (4AP), a drug currently used to treat patients with the chronic nerve disease, multiple sclerosis, has the unexpected property of promoting recovery from acute nerve damage. Although this drug has been studied for over 30 years for its ability to treat chronic diseases, this is the first demonstration of 4AP’s benefit in treating acute nerve injury and the first time those benefits were shown to persist after treatment was stopped.
Study authors, John Elfar, M.D., associate professor of Orthopaedics, and Mark Noble, Ph.D., Martha M. Freeman, M.D., Professor in Biomedical Genetics, and their laboratory team, found that daily treatment with 4AP promotes repair of myelin, the insulating material that normally surrounds nerve fibers, in mice. When this insulation is damaged, as occurs in traumatic peripheral nerve injury, nerve cell function is impaired. These researchers found that 4AP treatment accelerates repair of myelin damage and improvement in nerve function.Read More: Repurposed Drug May Offer Diagnosis, Treatment for Traumatic Nerve Damage
Catherine Ovitt Featured in D&C's Hot Jobs
Sunday, November 13, 2016
Dr. Catherine Ovitt
Salivary glands, which make as much as a quart of saliva each day, don’t pose a life-threatening risk if they stop working properly. But given their roles — they are important for swallowing, keep the inside of your mouth moist so your cheeks can move around, and have both anti-fungal and anti-bacterial properties — a malfunction would greatly impact quality of life.
Medical scientist Catherine Ovitt has dedicated her career to the study of salivary glands, in particular to establishing therapeutic strategies for their repair or regeneration after damage from radiation treatment due to head and neck cancers, or because of cellular damage from autoimmune diseases.
“A long-term goal would be to develop some sort of cell therapy treatment, some kind of transplantation or artificial salivary gland,” said Ovitt, who lives in Pittsford and is an associate professor in the Center for Oral Biology, part of UR Medicine’s Eastman Institute for Oral Health. Without the glands, she added, “you end up losing all your teeth.”Read More: Catherine Ovitt Featured in D&C's Hot Jobs
Karl Smith Featured as Part of MAG Hidden Passions Series
Tuesday, November 8, 2016
Biophysics PhD candidate, Karl Smith, is giving a talk at the Memorial Art Gallery, this Thursday at 7pm as part of their Hidden Passions speaking series.
At URMC, Smith studies glass filters 10,000 times thinner than a human hair as part of the Nanomembranes Research Group. It’s because of his rigorous academic schedule that he began the 10-cent project.
The Pittsburgh native has written more than 900 stories, each roughly 500 words, on half sheets of paper. Strangers give him a prompt, and he pecks away. He’s crafted stories about lost loves, lost dogs, sea lions, flying princesses, and frogs who jump over the moon. Stories about babies, treehouses, aardvarks, and dancing polar bears. Stories about murder.
Read more about Karl and his passion.
Monique Mendes Accepted to SfN's Neuronline Community Leaders Program
Tuesday, November 1, 2016
NGP student, Monique Mendes, was recently accepted into the SfN's Neuronline Community Leaders Program. This was a highly competitive process where only 35 of the nearly 100 applicants. Neuronline Community Leaders will be vital players in sparking and guiding different conversations by sharing their knowledge and insights with others in the field of neuroscience. Through their expertise and experiences, Neuronline Community Leaders will help create meaningful discussion and contribute to members feeling connected and supported between annual SfN meetings — playing a key role in SfN’s organizational mission to host great venues where great science gets shared.
Congratulations Monique!!!Read More: Monique Mendes Accepted to SfN's Neuronline Community Leaders Program
Thomas Mariani Authors Study on Infant Nose, Lung Cells
Thursday, October 13, 2016
Cells from an infant’s nose are remarkably similar to those found in the lungs, a discovery that could lead to much more precise diagnosis of respiratory syncytial virus (RSV) and other infant lung diseases, according to new URMC research.
The study, published in Scientific Reports, provides a potential avenue for diagnosis that has challenged physicians for years, as infants with respiratory disease are usually so fragile that attempting to obtain lung samples is unsafe. Nasal cells, however, can be captured through a simple swab of the nostril, and their similarity to lung cells on an RNA level would allow physicians to get an accurate representation of how the lung is responding during disease states, without the need for more invasive tests.
“An infant with RSV could potentially have their nasal cells tested to determine if they are among the small group that will develop a severe response that might require hospitalization,” said Thomas Mariani, Ph.D., professor of Pediatrics and the study’s lead author. “Additionally, we could potentially use this method to examine other at-risk infants, such as those born prematurely who face a greater risk for lung disease throughout life — and identify which of those children should be treated more aggressively.”
The research also carries tremendous promise for future studies. While scientists have made significant progress over the past several decades to better understand adult lung diseases — such as chronic obstructive pulmonary disease and lung fibrosis — discovery has not been nearly as robust for infant diseases, due to the risks involved in securing lung tissue.
But the relative ease of obtaining nasal cells could accelerate understanding of how infant lungs respond to RSV and other diseases. While this study examined 53 healthy infants as a means of establishing a benchmark for normal cell structure, researchers at URMC have already begun studying the nasal tissue of diseased infants. Early results are promising.
“We’re actively working on studies in infants with lung diseases, and we’re showing quite clearly that we can identify differences between those with mild disease and those with more severe outcomes,” Mariani said.
The research is conducted by URMC’s Respiratory Pathogens Research Center, which coordinates its work with the national Respiratory Pathogens Research Center established by the National Institute of Allergy and Infectious Diseases. The Center, under the direction of David Topham, Ph.D., focuses on research that will lead to a better understanding of the interactions between respiratory pathogens, the immune system, and other genetic and environmental factors.
ChinYi Chu, M.S., Xing Qiu, Ph.D., Lu Wang, M.S., Soumyaroop Bhattacharya, M.S., M.Ed., Gerry Lofthus, Ph.D., Anthony Corbett, M.S., Jeanne Holden-Wiltse, M.S., Alex Grier, M.S., Brenda Tesini, M.D., Steve Gill, Ph.D., Ann Falsey, M.D., Mary Caserta, M.D., and Ed Walsh, M.D., from the University of Rochester, contributed to these studies.
Read More: Thomas Mariani Authors Study on Infant Nose, Lung Cells
Research Will Explore New Therapies for Huntington's Disease
Wednesday, October 12, 2016
A new award from the CHDI Foundation will advance promising research that aims to slow the progression of Huntington’s disease. The funding, anticipated to total more than $10.5 million over next five years, will help University of Rochester Medical Center (URMC) scientists develop a stem cell-based therapy that swaps sick brain cells for healthy ones.
The new award will go to the lab of Steve Goldman, M.D., Ph.D., the co-director of the URMC Center for Translational Neuromedicine, which has research operations in both Rochester and at the University of Copenhagen.
Huntington’s is a hereditary neurodegenerative disease characterized by the loss of medium spiny neurons, a nerve cell in the brain that plays a critical role in motor control. As the disease progresses over time and more of these cells die, the result is involuntary movements, problems with coordination, and cognitive decline, depression, and often psychosis. There is currently no way to slow or modify this fatal disease.
The new award will support research that builds upon findings published by Goldman earlier this year in the journal Nature Communications showing that researchers were able to slow the progression of the disease in mice by transplanting healthy human support cells, called glial progenitor cells, into the animals’ brains.Read More: Research Will Explore New Therapies for Huntington's Disease
Wilmot Scientists Exploit Cell Metabolism to Attack Cancer
Wednesday, October 12, 2016
Cancer cells have their own unique ways of reproducing, involving a shrewd metabolic reprograming that has been observed in virtually all types of cancer but not in normal cells. Now, University of Rochester Medical Center scientists have pinpointed one key source of the problem, which could lead to new treatment opportunities.
In an article published by Cell Reports, the scientific team shows for the first time how cancer-causing mutations control and alter the way cancer cells biosynthesize and replicate.
The discovery is the result of a close collaboration between the laboratories of Joshua Munger, Ph.D., associate professor of Biochemistry and Biophysics, and Hucky Land, Ph.D., the Robert and Dorothy Markin Professor and Chair of Biomedical Genetics and director of research at the URMC’s Wilmot Cancer Institute.
“Every tissue or cell type in the body has different metabolic needs but as cells become cancerous their metabolism shifts in ways that are very different from normal cells,” Munger said. “Being able to identify those differences is critical for developing treatment targets.”Read More: Wilmot Scientists Exploit Cell Metabolism to Attack Cancer
Armond Collins Presents his work from Fudge Lab
Tuesday, October 11, 2016
Armond Collins, a second year medical student, presents the study he conducted with us this summer under the auspices of a Babigian Fellowship. Armond studied changes in myelination in amygdala and cortex of adult rats that had been exposed to 3 day bout of a repeated variable stressor during adolescence. His works follows up studies by Michele Saul, PhD that indicate that adolescent stress results in decreased oligodendrocyte precursors in the amygdala in the week following the stress.
NIH Director Visits URMC, Says it’s an Exciting Time to be a Researcher
Monday, October 10, 2016
Collins’ first stop was lunch with 15 graduate students and postdocs who came prepared with a wide range of questions. The discussion covered the importance of communicating science to the public and policymakers, increasing diversity in biomedical research and new mechanisms to support young scientists at the start of their careers. Postdoctoral fellow Sarah Latchney and Ph.D. graduate student Solomon Abiola attended the lunch with Collins and describe the experience here.
Members of the Center for RNA Biology highlighted their most promising work for Collins and Center director Lynne E. Maquat, Ph.D., gave Collins a tour of her lab, where he met more trainees and junior researchers (admittedly, Collins’ favorite part of visits like these).
In his keynote address at the end of the day, Collins delivered an uplifting message to a packed house in the Class of ’62 auditorium: it is an extremely exciting time to be in biomedical research, and after many lean years we are turning a corner, with the NIH budget finally increasing in real terms. He detailed several of the NIH’s new programs, like the Human Microbiome Project, Big Data to Knowledge (BD2K), the Precision Medicine Initiative and the Cancer Moonshot.
He applauded URMC on the renewal of the CTSI funding and cited the translational research conducted by Arthur J. Moss, M.D., which has led to new treatments for patients with Long QT syndrome (LQTS), and John J. Treanor, M.D., which is helping scientists in pursuit of a universal flu vaccine. Collins outlined several new funding initiatives, including the NIH Director’s Early Independence Award, which is helping assistant professor Elaine L. Hill, Ph.D., study the impact of fracking on infant and child health.
Collins affirmed that the U.S. is the strongest biomedical research country in the world thanks to institutions like URMC. You can view his keynote, “Exceptional Opportunities in Biomedical Research,” here.Read More: NIH Director Visits URMC, Says it’s an Exciting Time to be a Researcher
New Grants Explore Role of Brain’s “Garbage Truck” in Mini-Stokes and Trauma
Wednesday, October 5, 2016
Maiken Nedergaard, M.D., D.M.Sc.
More than $4.5 million in new grants to the lab of University of Rochester Medical Center scientist Maiken Nedergaard, M.D., D.M.Sc., underscore the important role the brain’s waste disposal system may play in a range of neurological disorders. The new awards will advance understanding of how small vessel disease and traumatic brain injury can give rise to cognitive and behavioral problems.
Nedergaard and her colleagues first unveiled the brain’s unique method of removing waste – dubbed the glymphatic system – in a paper in Science Translational Medicine in 2012. The research revealed that the brain possesses a circulation network that piggybacks on blood vessels and uses cerebral spinal fluid to flush away waste products from brain tissue. Since that time, the team has gone on to show that the glymphatic system works primarily while we sleep, could be a key player in diseases like Alzheimer’s, and is disrupted after traumatic brain injury.Read More: New Grants Explore Role of Brain’s “Garbage Truck” in Mini-Stokes and Trauma
NGP Student Awarded NIH Fellowship
Monday, October 3, 2016
Rebecca Rausch, a fifth year neuroscience graduate student in Dr. Richard Libby’s lab was awarded an NIH Individual Pre-doctoral Fellowship from the National Eye Institute for her project entitled: The Role of Notch and BMP Signaling in Anterior Segment Dysgenesis (2016-2019).
Nuclear Protein Causes Neuroblastoma to Become More Aggressive
Wednesday, September 28, 2016
Aggressive forms of neuroblastoma contain a specific protein in their cells’ nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center (URMC), could lead to new forms of targeted therapy.
EYA1, a protein that contributes to ear development, is present in the cytoplasm of many neuroblastoma tumors, but this protein migrates to the nucleus in the cells of more aggressive forms of the disease. The research, recently published in two medical research journals, allows for the development of targeted drugs that will work to prevent the neuroblastoma from reaching this more aggressive stage; researchers at URMC and elsewhere have already begun testing some of these potential treatments in a laboratory setting.
“Neuroblastoma is one of the most common and deadly forms of childhood cancer, and this discovery allows us to identify drugs that prevent the change in EYA1 structure and potentially minimize the danger to a child who has this disease,” said Nina Schor, M.D., Ph.D., professor of Pediatrics and Neuroscience and the William H. Eilinger Chair of Pediatrics at URMC.
Read More: Nuclear Protein Causes Neuroblastoma to Become More Aggressive
URMC Researchers Discover Rare Flu-Thwarting Mutation
Wednesday, September 28, 2016
A rare and improbable mutation in a protein encoded by an influenza virus renders the virus defenseless against the body’s immune system. This University of Rochester Medical Center discovery could provide a new strategy for live influenza vaccines in the future.
A new approach to the live flu vaccine would be particularly advantageous right now after the Centers for Disease Control and Prevention stopped recommending use of the live attenuate flu vaccine, FluMist® earlier this year. Several studies found that the pain-free nasal spray, which was used in about one-third of young children in the U.S., offered no protection to that especially vulnerable population. The flu shot, on the other hand, performed well and the CDC recommends using this vaccine in place of FluMist®.
“There is a need to understand what's happening with the existing live vaccine and potentially a need to develop a new one,” said David Topham, Ph.D., Marie Curran Wilson and Joseph Chamberlain Wilson Professor of Microbiology and Immunology at URMC and author of the study. “We proposed that the mutation we found could be used to create a live vaccine.”Read More: URMC Researchers Discover Rare Flu-Thwarting Mutation
Jessica Cantlon Named One of 10 Scientists to Watch by Science News
Friday, September 23, 2016
Jessica Cantlon, associate professor of Brain and Cognitive Sciences, was selected by Science News as one of their 10 early- to mid-career scientists to watch. Cantlon’s work centers on how human and nonhuman primates distinguish between quantities. Understanding how the brain makes sense of concepts such as estimating quantities and counting might lead to better ways of teaching numerical concepts to children.Read More: Jessica Cantlon Named One of 10 Scientists to Watch by Science News
American Health Council Names Dr. Harold Smith, Ph.D. to Education Board
Monday, September 19, 2016
Dr. Harold Smith, Professor at The University of Rochester, has been selected to join the Education Board at the American Health Council. Dr. Smith will be sharing his knowledge and expertise in the field of molecular biology, molecular virology, RNA biology, and drug discovery.
Dr. Harold Smith became involved in research after beginning his career as a professor in the Department of Biochemistry at The University of Rochester. As a biophysics professor, he utilized his knowledge and expertise in the areas of research and innovation of RNA, protein molecular biology, cell regulation, and drug discovery. Furthermore, Dr. Smith develops curriculum, teaches and mentors students from high school to postgraduate.
Dr. Harold Smith is also the Founder, President, and CEO of OyaGen, Inc. The objective of OyaGen, Inc. is to induce transient and beneficial changes in the protein expression and function in human tissues by involving the editing enzymes in targeting biomedically relevant pathways.
Dr. Harold Smith is a member of The American Heart Association, The Council on Atherosclerosis, The RNA Society, The American Society for Biochemistry and Molecular Biology and a fellow in the The Royal Society of Biology. In addition, Dr. Smith serves on the Scientific Advisor Board of Cannabis Sciences, Inc., IgxBio, Inc. and Trovita Health Sciences as well as the Editorial Board of the International Journal of Virology and AIDS, Frontiers in Microbiology, The Journal of Biological Chemistry, and The Journal of BioDiscovery.Read More: American Health Council Names Dr. Harold Smith, Ph.D. to Education Board
Miller Receives Patent for Technology that Can Help Detect Flu
Thursday, September 15, 2016
Benjamin L. Miller, Ph.D., professor of Dermatology, recently received yet another patent for a new technology that can detect miniscule amounts of specific molecules in blood or other liquids. The patent focuses on using this technology to make detecting immune responses to the flu quicker and easier.
The AIR™ Platform, marketed by Adarza Biosystems, can detect immune responses to flu vaccines as well as the virus itself. With a small blood sample from a patient, doctors can confirm a flu infection, see if the patient mounts an appropriate immune response to a vaccine, or see if immune responses cross react with several different strains of flu. AIR™ can also be used for viral surveillance.
While Miller’s AIR™ system is not the first to make these things possible, it is a great improvement on previous technologies. Its silicon chip, which is only about the size of the end of a pencil eraser, allows scientists to detect hundreds of different target molecules in a single drop of fluid, and its “label-free” design requires fewer steps and reagents, thus reducing cost and opportunities for error.
“Label-free” systems suppress background noise to detect tiny signals, whereas conventional “labeled” systems use a more cumbersome design to amplify a tiny signal, often creating a lot of background noise in the process.
“It’s like walking through a city during the day and looking up at the buildings,” Miller said. “You have no idea what's going on in the offices because there's so much ambient light, but if you come back at night, it's easy to see.”
Miller suppresses background noise using a near-perfect anti-reflective coating on his silicon chips. For every 100 million photons of light that hit the surface of the chip, only one photon is reflected back. That coating also contains capture molecules meant to bind or “capture” specific target molecules, like antibodies produced in response to the flu virus. The more antibodies that bind to the chip, the more the anti-reflective coating is perturbed, and the more light is reflected and captured by a camera.
This simple and unconventional design and the ability to use capture molecules both big and small makes AIR™ extremely versatile. From cancer and infectious diseases, to agriculture and food safety, AIR™ is poised to expedite research and clinical testing across a wide range of applications.
Haber, Farrar Receive Awards
Tuesday, September 13, 2016
Suzanne N. Haber, Ph.D., has been awarded a NIH R13 Conference grant. On October 11-13, 2016, the University of Rochester Institute of Neuromedicine and the Silvio O. Conte Center will hold a meeting entitled “Persistent, maladaptive behaviors: why we make bad choices”. The program is designed to involve basic and clinical scientists with a specific focus on the fundamental elements that drive basic behaviors and action plans (reward, fear, and value assignment); circuit dysfunctions that underlie abnormalities in diseases with persistent, habit-like behaviors, despite some awareness that these behaviors are maladaptive; the circuit components that are common amongst diseases; computational approaches to understanding these circuits; and therapeutic approaches that effect these circuits.
Christopher Farrar, a Ph.D. candidate in the lab of Professor Denise Hocking, has been awarded a Ruth L. Kirschstein National Research Service Award (NIH-NRSA) Individual Predoctoral Fellowship (F31) from the National Heart, Lung, and Blood Institute for his project entitled “Influence of Extracellular Matrix Fibronectin on Platelet-Derived Growth Factor (PDGF) Signaling”. PDGF is produced by a variety of different cell types and stimulates mesenchymal cell proliferation, migration, and gene expression. Together with fibronectin, PDGF plays an important role in angiogenesis and wound repair. In contrast, excess PDGF and abnormal fibronectin matrix deposition are linked to several diseases, including pulmonary fibrosis, atherosclerosis, and certain cancers. The focus of Chris’ project is to determine how mesenchymal cell adhesion to extracellular matrix fibronectin fibrils influences the ability of these cells to respond to PDGF, with the long-term goal of developing new treatment approaches to effectively regulate the sensitivity of cells to growth factor stimulation.
Harris Gelbard Receives International Award for Neurovirology Research
Tuesday, September 13, 2016
Harris “Handy” Gelbard, M.D., Ph.D., director of the Center for Neural Development & Disease, is slated to receive the Hilary Koprowski Prize in Neurovirology at this year’s International Symposium on Molecular Medicine and Infectious Disease at Drexel University. Gelbard will be recognized for developing an unconventional drug that shows promise in treating brain disorders associated with HIV.
Gelbard’s drug, URMC-099, calms the immune system when it goes awry, as happens in HIV Associated Neurocognitive Disorder (HAND). In HAND, immune reactions to HIV particles in the brain damage nerve cells and cause dementia. Because patients affected by HAND also have HIV, it was imperative that URMC-099 not interfere with the antiretroviral drugs that keep HIV-positive patients alive.
KL2 award helps researcher pave his career path
Friday, September 9, 2016
David Auerbach, senior instructor in medicine,
says his KL2 award has "opened many doors for me."
David Auerbach's interest in pursuing a scientific career began during a hockey game his first year of college, when a teammate — who turned out to be a chief medical examiner — asked Auerbach if he would like to observe a case.
Now Auerbach's career is taking a major step forward with a two-year KL2 Mentored Career Development Program award from the University's Clinical and Translational Science Institute.
"It has opened up many doors for me," says Auerbach, including lead authorship of a recent paper in Neurology.
Auerbach, a senior instructor in the Department of Medicine/Aab Cardiovascular Research Institute, is taking a multisystem approach to understanding the mechanisms that cause electrical disturbances in both the hearts and brains of patients with genetic ion channel diseases. Ion channels, located in the plasma membrane of cells, are narrow tunnels that open and close at precise times to allow the flow of ions into or out of the cell, thus shaping the electrical activity in the heart and brain.
As a postdoc working with Lori Isom, a professor at the University of Michigan, Auerbach demonstrated that people with severe genetic forms of epilepsy were at a higher risk not only of electrical disturbances in the brain, resulting in seizures, but also of electrical disturbances in the heart, causing arrhythmias.
In order to establish an independent line of research, Auerbach decided to approach the problem in reverse: are people with long QT syndrome — a classically studied genetic cardiac disease that causes arrhythmias — also at an increased risk of seizures?
He came to Rochester in 2014 specifically because of its research strengths in this area, including the opportunity to work with such experts as Arthur Moss, the Bradford Berk Distinguished Professor of Medicine; Robert Dirksen, the Lewis Pratt Ross Professor and chair of pharmacology and physiology; and Charles Lowenstein, chief of cardiology and director of the Aab Cardiovascular Research Institute.Read More: KL2 award helps researcher pave his career path
2016 Convocation Award Winners from Neuroscience
Thursday, September 8, 2016
Congratulations to the following people for winning teaching and student achievement awards at this year's SMD Opening Convocation.
Faculty Teaching, Mentoring & Diversity Awards
- Deborah Cory-Slechta, PhD
- John Olschowka, PhD
Medical & Graduate Student Achievement Awards
- Alexandra McHale - Irving L. Spar Fellowship Award
- Gavin Jenkins - Merritt and Marjorie Cleveland Fellowship
- Neal Shah - J. Newell Stannard Graduate Student Scholarship Award
- Grayson Sipe - Outstanding Student Mentor Award
Make sure to congratulate each of them when you see them.
Ann M. Dozier, PhD named Albert David Kaiser Chair of Public Health Sciences
Thursday, September 8, 2016
Ann M. Dozier, PhD, Professor Public Health Sciences, in the Center for Community Health, and of Clinical Nursing, named Albert David Kaiser Chair of Public Health Sciences at the Opening Convocation for the School of Medicine & Dentistry on September 8, 2016.
DOD Grant Explores New Drugs to Thwart Impact of Trauma, Stroke, and Cardiac Arrest
Thursday, September 8, 2016
A $2.3 million Department of Defense grant will help neuroscientists develop new treatments for the emergency room and the battlefield. The research will focus on the development of new therapies that could help protect brain and other at risk organs following a trauma, heart attack, or stroke.
“While we have made significant progress in our ability to restore blood flow after stroke or cardiac arrest, the medical community does not have drugs at its disposal to prevent the secondary damage that occurs after these events,” said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. “This grant will further our research on a promising class of drugs that possess both anti-inflammatory and cytoprotective properties that we believe will be suitable for use in both military and emergency conditions.”Read More: DOD Grant Explores New Drugs to Thwart Impact of Trauma, Stroke, and Cardiac Arrest
Kelly Thevenet-Morrison, M.S. awarded Outstanding Graduate Student Teacher award
Thursday, September 8, 2016
Kelly Thevenet-Morrison, M.S., Lead Programmer Analyst in the Department of Public Health Sciences, awarded Outstanding Graduate Student Teacher award at the Opening Convocation for the School of Medicine & Dentistry on September 8, 2016.
Anna Bird Receives Two Awards
Sunday, September 4, 2016
Anna Bird has received the Elkes Foundation Scholarship ($1200 in travel funds to the Keystone Symposium in Stockholm, Sweden) and the American Association of Immunologists (AAI) Trainee Abstract Award ($750 in travel funds for AAI Conference, Seattle 2016).
Automatic cortical representation of auditory pitch changes in Rett syndrome - John Foxe et al.
Thursday, September 1, 2016
Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones.Read More: Automatic cortical representation of auditory pitch changes in Rett syndrome - John Foxe et al.
Hayley Martin, MD-PhD student in Epidemiology receives student scholarship
Thursday, September 1, 2016
Hayley Martin, MD-PhD student in Epidemiology received a student scholarship to attend the 2016 Family Medicine Education Consortium Annual Meeting in Pittsburgh, PA. This meeting is aimed at family medicine physicians, residents and medical students in the north east interested in "improving the health of the community by strengthening Family Medicine / Primary Care services and medical education.
Biochemistry & Biophysics Faculty Member and Photojournalist Barry Goldstein Covers Republican National Convention for The American Scholar
Wednesday, August 31, 2016
Barry Goldstein is a photographer specializing in portraiture and documentary themes. Originally trained as a physician and biophysicist, he is Associate Professor of Medical Humanities at the University of Rochester Medical Center, Visiting Professor of Humanities at Williams College, and Adjunct Professor of Humanism in Medicine at the NYU Medical School. He was the first Artist-in-Residence at the New York University Medical School on September 11, 2001, an experience that led to his collection Being There: Medical Student Morgue Volunteers Following 9/11. His most recent book, Gray Land: Soldiers on War, is a collection of portraits of, and interviews with soldiers in Iraq and at home. He lectures and exhibits widely, and is a recipient of a Massachusetts Cultural Council Artists Grant in Photography.
Most recently, Barry provided coverage of the Republication National Convention for the American Scholar. His RNC work can be seen at The American Scholar and on his website.
Heilbronner and Yule Receive Awards at 2016 Convocation
Monday, August 29, 2016
Sarah R. Heilbronner, PhD, will receive the Postdoctoral Achievement Award at the 2016 Convocation, on September 8. She is currently a postdoc in Dr. Suzanne Haber's lab, where she is studying the neural circuitry associated with reward processing, decision-making, and executive function.
Along with the other members of Dr. Haber's team, Sarah is working to determine the anatomical connections that are affected by neurosurgical interventions for psychiatric disorders (such as deep brain stimulation).
Professor David I. Yule, Ph.D., will also receive the Faculty Teaching Award, specifically the Trainee Academic Mentoring Award in Basic Science, as well as the Louis C. Lasagna Endowed Professorship at convocation. The Yule Lab studies intracellular calcium signaling in cells which are typically, electrically non-excitable. In cells such as the liver, exocrine, pancreas, salivary glands and various cells in the blood, increases in intracellular calcium are fundamentally important for diverse processes including secretion of digestive enzymes and fluid, glucose metabolism together with cellular growth and differentiation.
Congrats Sarah and David!
Dr. Diana Fernandez assumes co-chair position of the Latino Health Coalition
Monday, August 15, 2016
Dr. Diana Fernandez, Associate Professor of Public Health Sciences, is assuming the co-chair position of the Latino Health Coalition convened by the Finger Lakes Health Systems Agency
Blanton Tolbert Wins Morton L. Mandel Award For Outstanding Chemistry Faculty
Tuesday, August 9, 2016
Former Biophysics student, Blanton Tolbert (PhD 2006), mentored by Doug Turner & Ravi Basavappa, has been awarded the Morton L. Mandel endows award for outstanding chemistry faculty members at Case Western Reserve University.
Associate Professor Blanton S. Tolbert, whose work focuses closely on elucidating molecular details of the human immunodeficiency virus, more commonly known as HIV. A member of the Case Western Reserve faculty since 2012, Tolbert paired the honor with extraordinary achievements during the past academic year:
- A featured cover story in the Journal of Molecular Biology that described new three-dimensional structures of molecules in the life cycle of HIV
- A second article about HIV’s molecular structures, published in the Journal of Biological Chemistry that became the journal’s most-viewed RNA (Ribonucleic acid) paper in December 2015
- Multiple online mentions of the work, including the Nov. 16 Science Highlights of the Advanced Photon Source at the U.S. Department of Energy’s Argonne National Library
- Service as director of the chemistry department’s Research Experience for Undergraduates (REU) grant from the National Science Foundation. In that role, Tolbert led efforts that identified and recruited a diverse group of students to work on federally sponsored projects. As part of the 10-week experience learning cutting-edge science, the students also participated in teambuilding and professional development activities. The work proved so successful that one undergraduate was cited as co-author on a publication from his summer project.
Congratulations Blanton!Read More: Blanton Tolbert Wins Morton L. Mandel Award For Outstanding Chemistry Faculty
How a Stone Spearhead Found in a Whale Could Help Solve the Mystery of Cancer
Monday, August 8, 2016
Bowhead whales can live over 200 years, but there is no evidence of a bowhead ever having cancer. "The biggest questions are what are the extra protections that whales have against cancer," says Vera Gorbunova, the Doris Johns Cherry Professor in the Department of Biology. "We would really like to understand the mechanism."Read More: How a Stone Spearhead Found in a Whale Could Help Solve the Mystery of Cancer
Lin Honored as 'Brilliant New Investigator'
Thursday, August 4, 2016
University of Rochester Assistant Professor of Nursing Feng (Vankee) Lin, Ph.D., R.N. will be presented with the Brilliant New Investigator Award from the Council for the Advancement of Nursing Science (CANS) at the organization’s 2016 State of the Science Congress on Nursing Research, Sept. 15-17 in Washington, D.C.
The award recognizes the contributions of scientists early in their research careers who show extraordinary potential to develop sustained programs of research certain to have significant impact on the science and practice of nursing and health care. Nominees must show a record of building research productivity in an area of major significance to nursing and health care, research dissemination and translation to practice and/or policy, and emerging leadership related to the advancement of nursing science.Read More: Lin Honored as 'Brilliant New Investigator'
Pasternak Research Paper to be Published in J. Neuroscience
Thursday, August 4, 2016
The paper "Prefrontal Neurons Represent Motion Signals from Across
the Visual Field but for Memory-Guided Comparisons
Depend on Neurons Providing these Signals" will be published in J. Neuroscience shortly.
Visual decisions often involve comparisons of sequential visual motion that can appear at any location in the visual field. We
show that during such comparisons, the lateral prefrontal cortex (LPFC) contains accurate representation of visual motion
from across the visual field, supplied by motion processing neurons. However, at the time of comparison, LPFC neurons can
only use this information to compute the differences between the stimuli, if stimuli appear at the same retinal location,
implicating neurons with localized receptive fields in the comparison process. These findings show that sensory comparisons
rely on the interactions between LPFC and sensory neurons that not only supply sensory signals but also actively
participate in the comparison of these signals at the time of the decision.
Make sure to read the article when it comes out.
University of Rochester rising junior completes research project on infant feeding
Monday, August 1, 2016
Yareni Sime, a University of Rochester rising junior and Scholar in the Ronald E. McNair Post-Baccalaureate Achievement Program, was hosted this summer by Dr. Ann Dozier and her team that is studying infant feeding, health and safety. Ms. Sime's summer research project was entitled Suboptimal Infant Feeding Practices Among Hispanic/Latino Women in Monroe County.
Maquat Featured at Cornell-Ithaca Creativity Workshop
Saturday, July 30, 2016
J. Lowell Orbison Chair of Biochemistry and Biophysics, and of Oncology, Lynne Maquat, PhD, was a featured speaker at The Creativity Spark: a creativity workshop for scientists, a workshop put on by Cornell University, July 25.
The creativity workshop featured award winning scientists and scholars, including two Nobel Laureates, as they discussed the Creativity Spark and its role in science exploration.
Luebke and Bennetto Explore Hearing Test That May Identify Autism Risk
Monday, July 25, 2016
Researchers have identified an inner ear deficiency in children with Autism that may impact their ability to recognize speech. The findings, which were published in the journal Autism Research, could ultimately be used as a way to identify children at risk for the disorder at an early age.
“This study identifies a simple, safe, and non-invasive method to screen young children for hearing deficits that are associated with Autism,” said Anne Luebke, Ph.D., an associate professor in the University of Rochester Medical Center Departments of Biomedical Engineering and Neuroscience and a co-author of the study. “This technique may provide clinicians a new window into the disorder and enable us to intervene earlier and help achieve optimal outcomes.”
“Auditory impairment has long been associated with developmental delay and other problems, such as language deficits,” said Loisa Bennetto, Ph.D., an associate professor in the University of Rochester Department of Clinical and Social Sciences in Psychology and a co-author of the study. “While there is no association between hearing problems and autism, difficulty in processing speech may contribute to some of the core symptoms of the disease. Early detection could help identify risk for ASD and enable clinicians to intervene earlier. Additionally, these findings can inform the development of approaches to correct auditory impairment with hearing aids or other devices that can improve the range of sounds the ear can process.”Read More: Luebke and Bennetto Explore Hearing Test That May Identify Autism Risk
McNair Summer Scholar Ashley Bui Talks Amygdala Circuits
Friday, July 22, 2016
Congratulations to Ashley Bui, a rising senior in Brain and Cognitive Sciences, on her presentation July 22, 2016. Her talk Projections from the Temporal Cortex to the Basal Nucleus of the Amygdala in the Macaque highlighted data from her summer project in our lab. The amygdala is required for computing which of the complex sensory stimuli that an individual encounters are emotionally meaningful, so that appropriate action can be taken. Ashley’s preliminary data shows that specific portions of the temporal cortex, which are critical for processing complex visual and auditory information, communicate with different regions of the amygdala. The results suggest that cortical areas that process complex visual information on 'what' and 'where' an object is (or is moving) are communicating with specific amygdala subregions. Thus, while determining the emotional importance of ‘what or who’ is important, biologic movements also likely influence amygdala activity and coding. We are happy that she will continue this work through the Fall semester.
NGP student plays with RPO
Thursday, July 21, 2016
Second year NGP student, Monique Mendes, had a unique opportunity to play alongside the Rochester Philharmonic Orchestra in their Side-by-Side Reading Session – a program that pairs amateur and professional musicians in a joint rehearsal and performance at Kodak Hall on July 21st.
Ryan Dawes defends thesis
Monday, July 18, 2016
Ryan Dawes successfully defended his thesis, "β-Adrenergic Receptor Signaling Constrains Breast Cancer Progression and
Modulates Tumor-Associated Exosome Content And Function" on July 18, 2016.
Congratulations Dr. Dawes!
Minsoo Kim Wins Dolph O. Adams Award
Friday, July 15, 2016
Congratulations to professor of Microbiology and Immunology and The Center for Vaccine Biology and Immunology, Minsoo Kim, who has won the 2016 Dolph O. Adams Award. Dr. Kim will be accepting the award at the SLB Annual Meeting in September in Verona Italy!
This annual award is named in honor of the outstanding macrophage researcher Dolph O. Adams, M.D., Ph.D. The award is to recognize excellence of an investigator working in the area of cellular and molecular mechanisms of host defense and inflammation.
Lisa A. DeLouise Receives Patent for Microfluidic Device
Friday, July 8, 2016
Lisa A. DeLouise, Ph.D., M.P.D., associate professor of Dermatology, Biomedical Engineering, Material Chemistry and Electrical and Computer Engineering and a member of the Environmental Health and Science Center, has received a patent for her microfluidic device and a method of manufacturing the device.
Research in the DeLouise Lab – funded by NYSTAR, NSF, DCFAR, CTSI and URVentures – has led to the development of a single cell screening technology platform based on microbubble well array. Single cell screening technologies can facilitate the discovery of rare cells.
DeLouise’s current work, in collaboration with James J. Kobie, Ph.D., assistant professor of Infectious Diseases, seeks to sort antigen-specific antibody-secreting B cells for the development of therapeutic monoclonal antibodies and the detection of cancer stem cells that harbor genetic mutations that confer their tumor-initiating and drug-resistant properties.
Meet Karl Smith, the Typewriting Tale Teller
Friday, July 8, 2016
The "Friends of Joe's Big Idea" is a vibrant community of talented people we think you should meet. With our feature, FOJBI Friday, we're introducing some of these cool communicators of science in their own words. This week: Karl Smith.
I'm a fifth-year biophysics doctoral candidate at the University of Rochester, where I study porous ultrathin silicon membranes. At the moment I'm taking a brief break from my research to be an American Academy for the Advancement of Science Mass Media Fellow at the Manhattan office of Scientific American.
Importance of science communication
I love science communication because it's both hard and important. People need to be told what scientists have discovered and what it means for their lives, but to do that well requires balancing the storytelling needs of journalism against objectivity and sober contextualization. Also, I personally find scientists to be generally fascinating people to write about and hear from.
Along with my co-producer Madeline Sofia, I created The Bench Warmer's Podcast, which tells stories of misadventures and victories in science using interviews with current and former graduate students. I think the stories that don't often get told about science — the scoops, the failures, the dead ends, rewrites and rejections — are just as important to tell as the wild success stories. Not only that, but I think we short-sell our successes by not highlighting how rare they are. So, in the podcast, Maddie and I ask questions like "What's the most expensive thing you ever broke in lab?" and "Have you ever embarrassed yourself by dislocating your knee while singing karaoke onstage in front of hundreds of your scientific peers and possible future employers?"
I also write "10-cent stories" for children at the Rochester Museum and Science Center and at a few other places around Rochester. The children give me a prompt and in five minutes I use my typewriter to type them a tale. I've been doing this for about three years now, and I've written well over 800 stories. Sometimes the stories have a STEM bend to them, but sometimes they're just stories. I love this project for a lot of reasons, but most of all because it lets me make the world a stranger, more whimsical place.
I've only been at my fellowship for a few weeks, so I'm still deciding if I want to be a science journalist or if my plans lie elsewhere. This is a time of great flux for me, so I don't know yet where I'm heading. But I'm enjoying figuring it out.Read More: Meet Karl Smith, the Typewriting Tale Teller
Rebecca Lowery Defends Thesis
Thursday, July 7, 2016
Rebecca Lowery has successfully defended her thesis, "The Role of Microglia and Fractalkine Signaling in Experience-dependent Synaptic Plasticity". Congratulate her when you see her.
Congratulations Dr. Lowery!
David Yule appointed Louis C. Lasagna Professor
Tuesday, July 5, 2016
David Yule, professor of pharmacology and physiology, has been appointed the Louis C. Lasagna Professor in Experimental Therapeutics for five years, effective July 1. He retains his joint appointments as professor of medicine and as professor in the Center for Oral Biology.
For the past 15 years, Yule has studied calcium’s role in disorders in which calcium signaling and secretions are disrupted, such as Sjögren’s syndrome—in which patients experience dry mouth due to a lack of saliva—and acute pancreatitis.
Using state-of-the art imaging and electrophysiological techniques, Yule’s lab monitors calcium signals to achieve a better understanding of the mechanisms that underlie these signals with the goal that the studies will give insight into the control of important physiological processes in both normal physiology and disease states.
Yule received his PhD in physiology from the University of Liverpool in the United Kingdom. His research has been published in numerous journals, including the Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Science Signaling, and the Journal of Physiology. Yule serves on the editorial board for Gastroenterology, the preeminent journal in the field of gastrointestinal disease.
The Lasagna professorship honors Louis Lasagna, who served as chair of the Department for Pharmacology from 1970 to 1983, and brought the department to national recognition as a center of training and research. Lasagna, who was known for pioneering the study of placebos and writing an alternative Hippocratic oath, died in 2003.
Read More: David Yule appointed Louis C. Lasagna Professor
URMC Team Revises Understanding of Genetic Code
Friday, July 1, 2016
Beth Grayhack, Ph.D., with lab
members and grad students
Christina Brule and Jiyu Wang
Scientists for years have known that the genetic code found in all living things contains many layers of complexity. But new research from the University of Rochester cracks the code more deeply, clarifying for example why some genes are inefficiently translated into proteins.
In a study published in the journal Cell, the researchers, co-led by Beth Grayhack, Ph.D., of the UR School of Medicine and Dentistry, discovered the existence and identity of 17 pairs of inefficient codons (DNA nucleotides or bases) within the genetic code.
Scientists have generally considered each piece of the genetic code (or codon) as a single “word” in a language. But the new data suggests some codon combinations act as compound words or phrases whose order and pairing has a significant impact on the translation of genes into proteins.
“Consider the words ‘pancake’ versus ‘cake pan,’ “ said Grayhack, an associate professor of Biochemistry and Biophysics, Pediatrics, and Cancer, in the Center for RNA Biology, at the UR Medical Center.Read More: URMC Team Revises Understanding of Genetic Code
The Sleep Hack Neuroscience Says Gives Your Brain Optimal Rest
Thursday, June 30, 2016
Sleep is critical for rest and rejuvenation. A human being will actually die of sleep deprivation before starvation--it takes about two weeks to starve, but only 10 days to die if you go without sleep.
The CDC has also classified insufficient sleep as a public health concern. Those who don't get enough sleep are more likely to suffer from chronic diseases that include hypertension, diabetes, depression, obesity, and cancer.
It's thus vital to get enough shuteye, but it turns out your sleep position also has a significant impact on the quality of rest you get.
Now, a neuroscience study suggests that of all sleep positions, one is most helpful when it comes to efficiently cleaning out waste from the brain: sleeping on your side.
The study, published in the Journal of Neuroscience, used dynamic contrast-enhanced MRI to image the brain's "glymphatic pathway." This is the system by which cerebrospinal fluid filters through the brain and swaps with interstitial fluid (the fluid around all other cells in the body).
"It is interesting that the lateral [side] sleep position is already the most popular in humans and most animals--even in the wild," said University of Rochester's Maiken Nedergaard. "It appears that we have adapted the lateral sleep position to most efficiently clear our brain of the metabolic waste products that build up while we are awake."Read More: The Sleep Hack Neuroscience Says Gives Your Brain Optimal Rest
6th Annual Stem Cell and Regenerative Medicine Symposium
Monday, June 27, 2016
Dr. Jack Kessler
In celebration of the NYSTEM-funded training program in stem cell biology at the University of Rochester, researchers convened for a day of presentations and discussions on advances in stem cell biology. To emphasize the excellence of our junior scientists, five NYSTEM trainees (both pre- and post-doctoral, took turns with leaders in the field of stem cell medicine to present their work. The meeting kicked off with a presentation by Dr. Jack Kessler, Northwestern University Feinberg School of Medicine) describing the factors controlling adult neural stem cell maintenance – a key determinant of cognitive health.
Dr. Kunle Odusi
Dr. Angela Christiano (center)
Dr. Kunle Odunsi (Roswell Park Cancer Institute) spoke in his role as director of the immune-therapy program on the importance of gene-engineered, tumor recognizing CD4 T-cells in anti-tumor therapy.
Dr. Angela Christiano (Columbia University) provided an impressive example of the power of iPSC technology with the development of 3D-skin tissue for treatment of such devastating skin diseases as epidermolysis bulbosa.
Presentations by NYSTEM trainees Fanju Meng (Biteau lab), Wenxuan Liu (Chakkalakal Lab), Michael Rudy (Mayer-Proschel Lab), Dr. Andrew Campbell (Proschel Labs), and Dr. Nicole Scott (Noble Lab) rounded out a day full of exciting new work that highlights the broad impact of stem cell biology on medicine today – and the success of the SCRMI training program. The meeting was buoyed by good vibes and food provided by the backdrop of the Rochester International Jazz Festival.
Congratulations To This Year’s Poster Prize Winners
Graduate Student Category
Zhonghe Ke, High Levels of Niche Ha of the NMR Mediates the Maintenance of LT-HSC by reducing ROS Levels, Gorbunova Lab
Jayme Olsen, Generation of Human Erythroblasts with Increased EX Vivo Self-Renewal, Palis Lab
Michael Trembley, Novel Mechanisms of the Epicardial-Derived Cell Mobilization, Small Lab
Pearl Quijada, Novel Mechanisms of Epicardium Dependent Cardiac Repair, Small Lab
Thank you to all participants for a great event. See you again in 2017!
Review: Giving Gene Editing Technology CRISPR-Cas9 a Boost
Thursday, June 23, 2016
A new gene editing technology called CRISPR-Cas9 has taken the scientific world by storm. It allows researchers to quickly and easily make changes to the DNA of humans, animals and plants. The hope is that CRISPR-Cas9 may be used in the future to eliminate or correct faulty genes that cause disease.
In a recent issue of the journal Cell, Lynne E. Maquat, Ph.D. and Maximilian W. Popp, Ph.D. of the University of Rochester Center for RNA Biology describe how scientists can make this technology more efficient. Understanding the principles of nonsense-mediated mRNA decay (NMD), a cellular mechanism that Maquat discovered early in her career, will help anyone employing the technology achieve a better result – namely, a more complete knock out or deletion of a desired gene.
Read More: Review: Giving Gene Editing Technology CRISPR-Cas9 a Boost
Catherine Ovitt receives 2016 IADR Innovation in Oral Care Award
Wednesday, June 22, 2016
Catherine Ovitt is one of this year’s three recipients of the 2016 IADR Innovation in Oral Care Awards. She accepted the award from IADR President Dr. Marc Heft at the IADR/APR General Session & Exhibition in Seoul, Republic of Korea. The three prestigious awards recognize research in innovative oral care technologies that may maintain and improve oral health, and are supported by GlaxoSmithKline.Read More: Catherine Ovitt receives 2016 IADR Innovation in Oral Care Award
Elissa Wong receives Neuman Scholarship Award
Tuesday, June 21, 2016
Elissa Wong, a fifth year toxicology graduate student in Ania Majewska’s lab, received the Margaret and William F. Neuman Scholarship Award in Environmental Medicine for exemplary scholarship and citizenship. Dr. William Neuman was the chair of the Department of Radiation Biology and Biophysics for many years and helped to create the Toxicology Training Program and the Environmental Health Science Center. Dr. Margaret Neuman received her PhD in Biochemistry from the University of Rochester. Later, working here, she researched the effects of uranium on bone biochemistry, and was an expert on the regulation of bone minerals.
The criteria for receiving this are as follows: 1) scholarship, 2) scientific excellence, 3) productivity, and 4) exceptional citizenship to the field of toxicology.
Claire McCarthy Wins Travel Award
Monday, June 13, 2016
Congratulations to Claire McCarthy, the newest recipient of the Medical Faculty Council UR-SMD Trainee/Student Travel Award for Spring 2016.
Clara Kielkopf Receives EvansMDS Discovery Research Grant
Saturday, June 11, 2016
Biochemistry & Biophysics Associate Professor, Clara Kielkopf's project, entitled, Structural mechanisms and targeting of MOS-relevant pre-mRNA splicing factors has been selected by EvansMDS for funding for 2016. This year EvansMDS requested 12 full DRG proposals and were able to fund 6 of them. Their hope is that these findings will translate into improvements in therapy that can be delivered to MDS patients.
The Kielkopf lab investigates splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects and splice sites and their associated proteins as therapeutic targets.
Mallory Scott Selected for Summer Internship at Bayer Pharmaceuticals
Friday, June 10, 2016
Mallory Scott, Biophysics, Structural and Computational Biology PhD student, in the laboratory of Dr. Paul Kammermeier, has been selected for a summer internship at Bayer Pharmaceuticals in Whippany, NJ in Global Regulatory Affairs. Mallory will gain valuable work experience in the healthcare industry while working with regulatory professionals on various projects to learn about the role of regulatory affairs in drug development and product registration as well as the regulatory landscape. Mallory will be working in the Chemistry, Manufacturing and Controls (CMC) division. Her project is focused on quality by design in continuous manufacturing.
Swapping Sick for Healthy Brain Cells Slows Huntington’s Disease
Tuesday, June 7, 2016
Researchers have successfully reduced the symptoms and slowed the progression of Huntington’s disease in mice using healthy human brain cells. The findings, which were published today in the journal Nature Communications, could ultimately point to a new method to treat the disease.
The research entailed implanting the animals with human glia cells derived from stem cells. One of the roles of glia, an important support cell found in the brain, is to tend to the health of neurons and the study’s findings show that replacing sick mouse glia with healthy human cells blunted the progress of the disease and rescued nerve cells at risk of death.
“The role that glia cells play in the progression of Huntington’s disease has never really been explored,” said Steve Goldman, M.D., Ph.D., co-director of the University of Rochester Center for Translational Neuromedicine. “This study shows that these cells are not only important actors in the disease, but may also hold the key to new treatment strategies.” Read More: Swapping Sick for Healthy Brain Cells Slows Huntington’s Disease
Harold Smith Publishes Commentary on RNA and DNA Editing
Sunday, June 5, 2016
Epigenetics is a popular, yet still mysterious concept in health and medicine. It’s the study of a variety of biological processes that alter the expression of our genes. Sometimes this involves modifying the structure of our chromosomes to mask or unmask genes, and other times the actual genetic code is changed in certain cells. Harold C. Smith, Ph.D., a longtime professor of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry has studied epigenetics in a research focus known as RNA and DNA editing since it was introduced two decades ago. He was invited to write a commentary on the progress and future of this research, published today in Trends in Biochemical Sciences, and answers a few questions about the subject.Read More: Harold Smith Publishes Commentary on RNA and DNA Editing
Post-doctoral Fellow wins the 2016 Weiss Toxicology Scholar Award
Wednesday, June 1, 2016
Dr. Luisa Caetano-Davies (Biomedical Genetics) was the postdoctoral winner of the third annual Weiss Toxicology Award. The award was created to strengthen training and research in the Toxicology Training Program by enhancing support of talented future leaders in the field of toxicology, particularly those with an interest in neurotoxicology. The award is presented annually to a meritorious trainee with an interest in Neurotoxicology. Dr. Caetano-Davies is member of the Proschel lab and is studying the effects of environmental toxicants on early stages of Parkinson Disease pathology, in particular with a focus on astrocyte dysfunction. Carolyn Klocke (Cory-Schlechta Lab) was the winner of the graduate student category. Congratulations!
2016 Graduating Class
Wednesday, June 1, 2016
We had 22 total graduates this year: 1 Epidemiology PHD, 17 Masters’ in Public Health, 3 Masters’ in Clinical Investigation and 1 Masters in Health Services Research and Policy. Congratulations to all of our graduates!Read More: 2016 Graduating Class
Dr. Michael Nussenzweig Gives Melville A. Hare Lecture
Monday, May 30, 2016
Michael Nussenzweig, M.D., Ph.D. gave the Melville Hare Memorial Lecture on May 12. The lecture, "The HIV Vaccine Problem" was organized by the students of the Department of Microbiology and Immunology and co-sponsored by the University of Rochester Center for AIDS Research.
GDSC Graduate Nirmalya Chatterjee reports a novel role of Bet proteins in the control of the oxidative stress response pathway.
Friday, May 27, 2016
Bet proteins are a subclass of bromodomain containing epigenetic “readers”. These proteins have complex and incompletely understood functions in the control of gene expression and chromatin organization. The human Bet proteins Brd3 and Brd4 have been implicated in cancer and thanks to the availability of specific inhibitors, have emerged as promising drug targets. The paper by Nirmalya Chatterjee, Min Tian and others describes experiments in Drosophila that discovered a novel function for Bet proteins: the regulation of the transcription factor Nrf2. The reported data show that a Drosophila Bet protein is part of a previously unknown pathway that can control Nrf2 activity. This is of interest as Nrf2 plays a prominent role in the defense against oxidative stress, protection against various diseases, and aging. Nirmalya Chatterjee, a recent member of the Bohmann Lab, received the PhD last September and is currently working as a postdoc in the group of Norbert Perrimon at Harvard Medical School.
Nirmalya Chatterjee2, Min Tian3, M., Kerstin Spirohn, Michael Boutros & Dirk Bohmann (2016) Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein, PLoS Genetics, will go to press 5/27/2016. PMID: 27233051
Congratulations to all of our Retreat awards winners
Thursday, May 26, 2016
The Toxicology program would like to congratulate the following on their 2016 Retreat awards:
- Elissa Wong won the William F. and Margaret W. Neuman Award for exemplary scholarship and citizenship in the Toxicology Training Program
- Amanda Croasdell won the (student) Robert F. Infurna Award for publishing the best research paper in toxicology (this award was started in 1998)
- Lisbeth Boule won the (postdoc) Robert F. Infurna Award for publishing the best research paper in toxicology (this award was started in 1998)
- Carolyn Klocke won the (student) Weiss Toxicology Scholar Award
- Luisa Caetano-Davies won the (Postdoc) Weiss Toxicology Scholar Award
Luisa Caetano-Davies wins “Best Oral Presentation” Award.
Thursday, May 26, 2016
Luisa, a post-doctoral fellow in the Proschel Lab
, received the award for her presentation on “Astrocyte dysfunction in Parkinson Disease” at the 2016 Environmental Medicine and Toxicology Training Program retreat. Her presentation described the use of both iPSC-based disease-in-a-dish and in vivo animal models to identify early astrocyte defects in PD disease etiology. Congratulations, Luisa!
Congratulations Karl Smith, AAAS Mass Media Fellowship Recipient
Monday, May 23, 2016
Karl Smith, 5th year graduate student in the Biophysics Structural and Computational Biology PhD program, laboratory of Dr. Jim McGrath, has received an AAAS (American Association for the Advancement of Science) Mass Media Fellowship. Karl, sponsored by the American Physical Society, will be spending 10 weeks this summer working at Scientific American in their Manhattan offices as part of his fellowship.
Since its inception, the AAAS Fellowship Program has supported more than 625 student scientists, engineers and medical professionals who, in some cases, produced the only original science-news reporting at their assigned media outlets over the summer. The current 15 fellows, selected from a pool of 130 outstanding applicants, are likely to generate between 200 and 300 original science stories for print articles, blogs, podcasts, radio segments, and multimedia features.
Past participants in the Mass Media Fellows program include Mark Dumont, Professor, Department of Biochemistry and Biophysics, who received the AAAS Mass Media Fellowship in 1975, the second year that it was in existence. Over that summer, he wrote 26 news articles for the San Diego Union.
Other recipients include Erica Goode and Kenneth Chang of the New York Times; Richard Harris, David Kestenbaum, and Joe Palca of NPR; renowned biologist Eric Lander, co-chair of U.S. President Barack Obama's Council of Advisors on Science and Technology; physician and "Law & Order: Special Victims Unit" Executive Producer Neal Baer; Victoria Bruce, author of No Apparent Danger: The True Story of Volcanic Disaster at Galeras and Nevado Del Ruiz; and many others. - from AAAS's website.
GDSC Student Xuan Li publishes on the role of Cdk12 in response to stress.
Monday, May 23, 2016
The phosphorylation of RNA polymerase II in the C-terminal domain, or CTD, is an essential step for the transcription of all eukaryotic protein coding genes. The paper be Xuan Li and colleagues describes the unexpected discovery that a certain CTD kinase, called CDK12, is not universally required, but is only needed for the transcription of genes that are inducible by stress, such as heat, DNA damage or reactive oxygen species. This finding suggests that CTD phosphorylation plays a role in the regulation of specific gene expression programs, rather than being a generic step of transcription. This work involved a large-scale robotic RNAi screen in collaboration with the Boutros lab in Heidelberg, as well as genetic and biochemical experiments in the Drosophila model system. Xuan Li, a graduate student in the Bohmann Lab is currently doing an internship at Takeda Pharmaceuticals in Boston and will defend her PhD in November.
Xuan Li1, Nirmalya Chatterjee2,, Kerstin Spirohn, Michael Boutros & Dirk Bohmann (2016) Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Scientific Reports, 6:21455. PMID: 26911346
Proposal by Amy Kiernan Receives University Research Award
Monday, May 23, 2016
A collaborative project involving Associate Professor Amy Kiernan of the Flaum Eye Institute has been chosen as one of the 2016-17 University Research Awards. One of just eight applications chosen by senior research leadership, the proposal entitled, "Understanding cell turnover and injury recovery in the corneal endothelium” will be funded $75.000 annually.
Conventional Radiation Therapy May Not Protect Healthy Brain Cells
Wednesday, May 18, 2016
A new study shows that repeated radiation therapy used to target tumors in the brain may not be as safe to healthy brain cells as previously assumed. The findings, which appear in the International Journal of Radiation Oncology, Biology, Physics, show that the treatment also kills important support cells in the brain and may cause as much, if not more damage, than single dose radiation therapy.
“This study suggests that conventional repeated radiation treatments offer no significant benefit to brain tumor patients,” said Kerry O’Banion, M.D., Ph.D., a professor in the University of Rochester Medical Center (URMC) Department of Neuroscience and lead author of the study. “It also shows that certain cell populations in the brain are vulnerable to radiation and this may help explain why so many brain cancer patients experience cognitive problems after treatment.” Read More: Conventional Radiation Therapy May Not Protect Healthy Brain Cells
Karl Smith places third in University’s Falling Walls Competition
Wednesday, May 18, 2016
Karl Smith, a PhD student in Biophysics and a member of the lab of James McGrath, Professor of Biomedical Engineering, won third place in the University of Rochester’s Falling Walls Competition for describing his use of physics to make water behind a filter form a mixer vortex, reducing the difficulty of normal stirring when fluids stick to surfaces. A total of 19 presenters competed.
The competition is associated with the Falling Walls foundation, a non-profit organization that fosters discussions on research and innovation and promotes the latest scientific findings to society. The Rochester winner’s idea will compete with others from around the world at the Falling Walls Lab Finale in November in Berlin. This event selects the participants for the annual Falling Walls Conference the following day: an international forum for science and innovation to commemorate the fall of the Berlin Wall. Speakers at the conference have included Angela Merkel, Chancellor of Germany; Nobel Prize winner Sir Paul Nurse; and young inventors from around the world. BBC London said it was where the “brightest minds on the planet” meet.
Last year’s Falling Walls Lab Rochester winner, Ryan Trombetta, a BME PhD student in Dr. Awad’s lab, finished 12th (out off a 100 finalists worldwide) in the Berlin competition for his description of using 3D printed bone grafts to treat osteomyelitis. See his presentation here.
From left to right, Solomon Abiola, Sara Nowacki and Karl Smith, the top three finishers at the Falling Walls Competition.
Cindy (Xiaowen) Wang in the Noble Lab wins 2016 GSS Poster Prize
Tuesday, May 17, 2016
Cindy (Xiaowen) Wang in the Noble Lab wins 2016 GSS Poster Prize with her work on:
Identifying c-Cbl as a critical point of intervention in acquired tamoxifen resistant breast cancer.
(Co-authors Jennifer L Stripay, Hsing-Yu Chen and Mark D Noble).
Garry Coles wins 2016 Vincent du Vigneaud Award For Excellence in Graduate Research
Tuesday, May 17, 2016
Garry Coles, graduate of the Genetics, Development and Stem Cell program received this years du Vigneaud commencement award. The University of Rochester School of Medicine and Dentistry recognizes outstanding post-baccalaureate research efforts and promising PhD candidates through the Vincent du Vigneaud Award, in honor of Vincent du Vigneaud, himself a PhD graduate of the University of Rochester and recipient of the 1955 Nobel Prize in Chemistry.
Gary's PhD thesis, entitled "KIF7 and microtubule dynamics function to regulate cellular proliferation and cell cycle progression" focuses on deciphering the role of Kinesin family member 7 (Kif7) on cell cycle control during mammalian development. The work was conducted in Dr. Kate Ackerman's laboratory and has been published in the Proceedings of National Academy of Sciences (PNAS), PLoS Genetics and Developmental Biology.
Dr. Wellington Cardoso, Director for the Center for Human Development at Columbia University Medical Center, comments: "I have been closely following the work of Dr. Coles and his mentor Dr. Kate Ackerman, since we share a similar research interest. Dr. Coles has made important contributions to our understanding of the mechanisms regulating diaphragm and lung morphogenesis… I am confident that he will continue to make great contributions to the field in his future career."
This outlook is also shared by Dr. Hartmut Land, Chair of the Department for Biomedical Genetics and Director of Research at the Wilmot Cancer Center: "Garry is an incredibly driven and inquisitive scientist, and he has a fabulous enthusiasm for his work…(He) has grown tremendously during his time in graduate school. His maturity and independence are ahead of the curve for most post-doctoral fellows." Dr. Land concludes, "Given (Garry's) exceptional talent to make things work, his curiosity and great persistence, I am certain that he will contribute significantly to any scientific environment... (and)… become a leader in his field".
Class of 2014 Prelim season begins
Thursday, May 12, 2016
On Friday, May 6th, Andrew Albee opened the 2016 season of Prelim Exams. According to his committee, Andrew passed his qualifying exam with flying colors, and the committee looks forward to the outcome of his work. His studies on the function of Lmx Homeobox transcription factors in early somatic progenitors of the Drosophila ovary are also the basis of an F31 application submitted in February of this year. Congratulations, Andrew!
28th Annual Genetics Day Meeting
Wednesday, May 11, 2016
Dr. Michael Levine
This year's Genetics Day provided another opportunity to celebrate the impact of Genetics on science and medicine. An excellent selection of speakers from the University of Rochester Medical Center highlighted the importance of diverse genetic mechanisms ranging from chromatin remodeling in erythropoesis (Laurie Steiner) and DNA damage repair (Xi Bin) to translational control by riboswitches (Joe Wedekind) and di-codon usage (Elizbeth Grayhack). Genetics Day concluded with the Fred Sherman lecture by Dr. Michael Levine (Princeton University). His presentation on visualizing the mechanisms of transcriptional enhancers was equally entertaining and insightful. Originally from the Hollywood area, and by his own admission a closet movie producer, Dr. Levine wowed audiences with in vivo movies of enhancer reporters, shedding new light on what we all thought was an established principle of molecular genetics.
Manisha Taya – Hammes Lab
The Role of Estrogen Signaling in a Mouse Model for Lymphangioleiomyomatosis (Lam)
Sam Carrell – Thornton Lab
Silencing of Myotonic Dystrophy Protein Kinase (Dmpk) Does Not Affect Cardiac or Muscle Function In Mice
Walter Knight – Yan Lab
The Role and Mechanism of Cyclic Nucleotide Phosphodiesterase 1c in Regulating Pathological Cardiac Remodeling and Dysfunction
Vincent Martinson - Jaenike lab
Gut Microbiota of Distantly Related Drosophila Species Share Similar Bacterial Diversity
Genetics Day has been a long standing tradition at the University of Rochester And more recently includes the Fred Sherman lecture in memory of Fred Sherman a renowned biochemist and geneticist, who led international efforts to establish the yeast Saccharomyces cerevisiae as the premier genetic eukaryotic model system. The lecture is made possible by a generous fund endowed by Fred Sherman's wife, Elena Rustchenko-Bulgac, herself a research professor at the URMC.
When the Physical World is Unreliable: Study Finds Visual and Tactile Processing Deficits in Schizophrenia
Tuesday, May 10, 2016
A new study out today in the journal Translational Psychiatry sheds further light on the idea that schizophrenia is a sensory disorder and that individuals with the condition are impaired in their ability to process stimuli from the outside world. The findings may also point to a new way to identify the disease at an early stage and before symptoms become acute.
Because one of the hallmarks of the disease is auditory hallucinations, such as hearing voices, researchers have long suspected a link between auditory processing and schizophrenia. The new study provides evidence that the filtering of incoming visual information, and also of simple touch inputs, is also severely compromised in individuals with the condition.
“When we think about schizophrenia, the first things that come to mind are the paranoia, the delusions, the disorganized thinking,” said John Foxe, Ph.D., the chair of the University of Rochester Medical Center Department of Neuroscience and senior author of the study. “But there is increasing evidence that there is something fundamentally wrong with the way these patients hear, the way they feel things through their sense of touch, and in the way in which they see the environment.”Read More: When the Physical World is Unreliable: Study Finds Visual and Tactile Processing Deficits in Schizophrenia
Denise Skrombolas Receives Award
Thursday, May 5, 2016
Dr. Denise Skrombolas was awarded the Rochester Vaccine Fellowship created by a donation from Dr. Michael Pichichero in honor of Dr. Porter Anderson one of the pioneers in the Hib vaccine.
Jennifer Judge Wins the University of Rochester’s Three Minute Thesis (3MT) Competition
Wednesday, May 4, 2016
Jennifer Judge presenting at the 3MT competition
Jennifer Judge, a Toxicology graduate student in the Sime Lab, has won the Judge's Vote and People's Choice Award at the University of Rochester’s Three Minute Thesis (3MT) competition. The event was held today in the Class of ’62 auditorium, as 8 finalists delivered their research in only three minutes.
The judges will picked a winner ($1,000 in travel funds), then the students voted for whom they thought should receive the
People’s Choice award ($500 in travel funds!). Congrats to Jennifer for winning both!
SA Government names Professors of the Year
Monday, May 2, 2016
Join us in congratulating Laurel for being selected as one of 4 Professors of the year from a extraordinary field of 63 candidates.
Laurel Carney, professor of biomedical engineering, won in the Engineering field. Her research focuses on the complex network of auditory nerve fibers that transmit the inner ear’s electrical signals to the brain with the goal of better hearing aids.
Carney earned her M.S. and Ph.D degrees in electrical engineering at the University of Wisconsin-Madison. She was an associate professor of biomedical engineering at Boston University and professor of biomedical engineering at Syracuse University before joining the Rochester faulty in 2007. She serves as professor in three departments – biomedical engineering, neurobiology and anatomy, and electrical and computer engineering.Read More: SA Government names Professors of the Year
Elissa Wong Awarded Individual Pre-doctoral Fellowship from NIAAA
Sunday, May 1, 2016
Elissa Wong, a 4th year Toxicology Graduate Program student in Dr. Ania Majewska's lab received a perfect 10 review score and was awarded an NIH (NRSA) Individual Pre-doctoral Fellowship from the NIAAA. The title of her project is: Synaptic plasticity and microglial-synapse interactions after developmental alcohol exposure (2016-2018).
NGP Graduate Alum, Grayson Sipe, Wins Doty Thesis Award
Friday, April 29, 2016
Grayson Sipe, recent doctoral graduate from the Majewska lab, received the Robert Doty prize for the 2016 outstanding dissertation in neuroscience. The Doty prize is named in the honor of longtime faculty member Robert Doty, who made great contributions to neuroscience research at the University of Rochester and nationally. It is awarded on the basis of the impact and importance of research, novelty of experimental design, independence and creativity of the student and research implications and relevance for neuroscience. Grayson’s thesis entitled “The Role of P2Y12 in non-pathological microglial functions during synaptic plasticity”, which he successfully defended on February 19th, 2016, embodied all these characteristics. Grayson has now moved to his postdoctoral position with Dr. Mriganka Sur at MIT. Dr. Peter Shrager presented Grayson the prize at the annual neuroscience retreat on Friday, April 29th.
Subtle Chemical Changes in Brain Can Alter Sleep-Wake Cycle
Friday, April 29, 2016
A study out today in the journal Science sheds new light on the biological mechanisms that control the sleep-wake cycle. Specifically, it shows that a simple shift in the balance of chemicals found in the fluid that bathes and surrounds brain cells can alter the state of consciousness of animals.
The study, which focuses on a collection of ions that reside in the cerebral spinal fluid (CSF), found that not only do these changes play a key role in stimulating or dampening the activity of nerve cells, but they also appear to alter cell volume causing brain cells to shrink while we sleep, a process that facilitates the removal of waste.
“Understanding what drives arousal is essential to deciphering consciousness and the lack thereof during sleep,” said Maiken Nedergaard, M.D., D.M.Sc., co-director of the University of Rochester Center for Translational Neuromedicine and lead author of the study. “We found that the transition from wakefulness to sleep is accompanied by a marked and sustained change in the concentration of key extracellular ions and the volume of the extracellular space.”
The current scientific consensus is that the brain is “woken up” by a set of neurotransmitters – which include compounds such as acetylcholine, hypocretin, histamine, serotonin, noradrenaline, and dopamine – that originate from structures deep within the brain and the brain stem. This cocktail of chemical messengers serve to activate – or arouse – a set of neurons in the cerebral cortex and other parts of the brain responsible for memory, thinking, and learning, placing the brain in a state of wakefulness.Read More: Subtle Chemical Changes in Brain Can Alter Sleep-Wake Cycle
Heather Natola Wins 2016 Edward Peck Curtis Award for Excellence in Undergraduate Teaching
Thursday, April 28, 2016
We are proud to announce that Heather Natola has been selected to receive the 2016 Edward Peck Curtis Awards for Excellence in Undergraduate Teaching. Ms. Natola received high praise from her students, faculty in the Department of Biomedical Genetics and Rochester Museum and Science Center.
Ms. Natola is a graduate student researcher in the Pröschel Lab, where she investigates new therapeutic approaches to spinal cord injury as part of the UR Stem Cell and Regenerative Medicine Institute.
"Ms. Natola was particularly instrumental in providing students with in-depth and detailed training, which had a significant positive impact on the student’s engagement and learning"
-Hartmut Land, Ph.D., Chair, Department of Biomedical Genetics
"Despite her ambitious and demanding research work, Heather has volunteered for all of these teaching activities. Clearly she has not only become an ambassador for science as a whole, but has helped fulfill the mission of our school. What more can we ask of a graduate student?"
Christoph Proschel, Ph.D., Program Director - Genetics Development & Stem Cells Ph.D. Program
Heather is enthusiastic and committed to promoting interest in science and an attitude of life-long learning
-Kara Verno, Program Supervisor - Rochester Museum and Science Center
Community Talk on Zika Virus Features Infectious Disease Expert from Brazil
Tuesday, April 19, 2016
As the warm summer season approaches, the possibility of a Zika outbreak in the United States looms large. The greatest concern is for women of childbearing age, as studies continue to link exposure to the virus in pregnancy to serious birth defects like microcephaly, hearing loss and blindness.
Esper Kallas, M.D., Ph.D., an infectious diseases specialist and professor of Medicine at the University of Sao Paulo, Brazil will speak about Zika virus on Monday, May 9 at 7:30 pm in the Eisenhart Auditorium at the Rochester Museum and Science Center. The event is free and open to the public. Kallas will be joined by a panel of experts from the University of Rochester Medical Center:Read More: Community Talk on Zika Virus Features Infectious Disease Expert from Brazil
Congratulations to NGP student Aleta Steevens
Friday, April 8, 2016
Aleta Stevens, an NGP student in Dr. Amy Kiernan's lab, secured a 3-year NIH Individual Pre-doctoral Fellowship, F31 entitled, "Elucidating the role of SOX2 in inner ear development."
Excellent work Aleta!
Harold Smith Inducted into Royal Society of Biology
Friday, April 8, 2016
Dr. Harold Smith, Professor of Biochemistry & Biophysics has been inducted into the Royal Society of Biology.
A long time member of the department, Dr. Smith's primary interest is understanding the composition, regulation and structure of macromolecular complexes involved in regulating gene expression at the level of messenger RNA expression and processing. The lab's focus is on a platform of enzymes that change the genetic code at the DNA or RNA level by deaminating cytidine to form uridine. Current data suggest that this family of cytidine deaminase function with other proteins (auxiliary proteins) as holoenzymes complexes which we refer to as editosomes (for RNA) or mutasomes (for DNA). RNA editing or DNA mutational activity by these enzymes affect the protein coding capacity of mRNAs and thereby can diversify the proteins that are expressed by cells (the proteome). Please visit the Smith Lab for more information. Dr. Smith has a 30 year track record of teaching and mentoring graduate students, medical students and undergraduates at the University of Rochester and has lead curriculum design and reform for these programs.
The Royal Society of Biology (RSB), previously called the Society of Biology, is a learned society in the United Kingdom created to advance the interests of biology in academia, industry, education, and research. Formed in 2009 by the merger of the Biosciences Federation and the Institute of Biology, the society has around 16,000 individual members, and over 100 member organizations. In addition to engaging the public on matters related to the life sciences, the society seeks to develop the profession and to guide the development of related policies.
Neuroscience Graduate Students Win Award for Teaching
Friday, April 8, 2016
Neuroscience Graduate Program students, Aleta Steevens (Dr. Amy Kiernan lab) and Heather Natola (Dr. Chris Pröschel lab) were awarded the 2016 Edward Peck Curtis Award for Excellence for Graduate Student Teaching.
Only a handful of these are awarded each year, and all this year's nominees were extremely well-qualified.
Congratulations to both!!!
Christina Cloninger Defends Thesis
Thursday, April 7, 2016
Congratulations Dr. Cloninger on successfully defending your thesis!!
“Honeycomb” of Nanotubes Could Boost Genetic Engineering
Wednesday, April 6, 2016
Electron microscope image of animal cells (colored blue) cultured on an array of carbon nanotubes
Researchers have developed a new and highly efficient method for gene transfer. The technique, which involves culturing and transfecting cells with genetic material on an array of carbon nanotubes, appears to overcome the limitations of other gene editing technologies.
The device, which is described in a study published today in the journal Small, is the product of a collaboration between researchers at the University of Rochester Medical Center (URMC) and the Rochester Institute of Technology (RIT).
“This platform holds the potential to make the gene transfer process more robust and decrease toxic effects, while increasing amount and diversity of genetic cargo we can deliver into cells,” said Ian Dickerson, Ph.D., an associate professor in the Department of Neuroscience at the URMC and co-author of the paper.Read More: “Honeycomb” of Nanotubes Could Boost Genetic Engineering
Study: The Science behind Bodily Secretions
Tuesday, April 5, 2016
The salivary gland secretes saliva that helps us chew and swallow the food we eat. The pancreas secretes digestive juices that enable our bodies to break down the fat, protein, and carbohydrates in the food. Secretions like these are important in countless activities that keep our bodies running day and night. A study published today in the journal Science Signaling uncovers a previously mysterious process that makes these secretions possible.
At the heart of the new study is calcium, which is present in all of our cells and is a gatekeeper of sorts: an increase in calcium in our cells opens up “gates” or “channels” that are required for the production and secretion of fluids like saliva. If calcium doesn’t increase inside cells the gates won’t open, a problem that occurs in diseases like Sjögren’s syndrome. Sjögren’s patients experience dry mouth due to a lack of saliva and have difficulty chewing, swallowing, and speaking, which severely hampers quality of life.
For the past 15 years David I. Yule, Ph.D., professor in the department of Pharmacology and Physiology at the University of Rochester School of Medicine and Dentistry has studied calcium’s role in Sjögren’s and other disorders in which calcium and secretions are disrupted, like acute pancreatitis. In the new study he answers an important question that has stumped scientists for years: what does it take for a particularly important calcium channel to open and start these processes?Read More: Study: The Science behind Bodily Secretions
Professor Harold Smith to Organize Meeting on Drug Discovery
Thursday, March 31, 2016
The Clinical Science and Drug Discovery Conference had its inaugural meeting in 2015 in Baltimore, MD where Dr. Smith was asked to serve as a Keynote Speaker (and judge for poster sessions). The organizers of that meeting nominated him to organize this years meeting in Dundee, Scotland along with Drs. Ian Catchpole from GlaxoSmithKline in the UK and Nikolai Zhelev, professor at Abertay University, the hosting institution. The meeting will be held July 27-29. Dr. Smith will also deliver a keynote lecture at this meeting and chair a special topics session that he is bringing together on 'Host Cell Factors as Therapeutic Targets'. For more information, please visit the Drug Discovery Summit site, see also the CSDD Brochure.
Q&A: Biologist earns raves for work with yeast
Wednesday, March 23, 2016
David Goldfarb, professor of biology and biochemistry, researches yeast as a model organism for understanding the aging process in humans. Goldfarb joined the Rochester faculty in 1988, five years after earning his PhD in biochemistry at the University of California, Davis, and completing postdoctoral work at Stanford University.
Goldfarb holds four patents and has been recognized with more than a dozen honors, including the Johnson & Johnson “Focused Giving Program” Award, the National Society of Collegiate Scholars Distinguished Member Award, and the March of Dimes Health Leadership Award in Education.Read More: Q&A: Biologist earns raves for work with yeast
Early Wiring of Brain's “Fear” Centers Could Produce Long-term Consequences
Monday, March 21, 2016
New research shows that our brains may be hardwired to become sensitive to stressful environments at an early age and, if overstimulated, this may contribute to anxiety disorders and even psychotic syndromes later in life.
The study, which appears in the journal Brain Structure and Function, focuses on two structures deep in the brain. The central nucleus of the amygdala (Ce) is thought to be involved in responses to immediate threats and stimulus, such as becoming startled or freezing in reaction to a loud noise. The bed nucleus of the stria terminalis (BST) is thought to be involved in regulating a person’s state of vigilance, such as determining whether or not an environment or a situation poses a potential threat. Animal and human studies show that when the BST is activated by a threatening situation, we tend to slow down, become quieter, and stress hormones spike.
While Ce and BST reside in different parts of the brain, the two areas are hardwired to each other by axonal tracts – basically, bundles of long distance axon fibers that enable the separate regions to communicate with each other. However, until now it has not been clear when these connections form or the way in which they interact with each other.
In the study published today, a team of researchers led by Julie Fudge, M.D., with the Department of Neuroscience observed that these connections are made at a very early stage of development in non-human primates. They also found that the direction of the connection is essentially a one way street. The Ce – or immediate fear signaling center – conveys information to the BST, the structure that mediates general threat sensing or anxiety states. This arrangement suggests that repeated activation of the Ce by immediately fearful or traumatic events may shape long-term anxiety states in the BST.Read More: Early Wiring of Brain's “Fear” Centers Could Produce Long-term Consequences
Omega 3 Fatty Acids May Reduce Bacterial Lung Infections Associated with COPD
Tuesday, March 15, 2016
Compounds derived from omega-3 fatty acids – like those found in salmon – might be the key to helping the body combat lung infections, according to researchers at the University of Rochester School of Medicine and Dentistry.
The omega-3 derivatives were effective at clearing a type of bacteria called Nontypeable Haemophilus influenzae (NTHi), which often plagues people with inflammatory diseases like chronic obstructive pulmonary disease (COPD).
COPD, which is most often caused by years of smoking, is characterized by inflammation and excessive mucus in the lungs that blocks airflow. Quitting can slow the progress of COPD, but it doesn’t halt the disease. Anti-inflammatory drugs are the most common treatment, however they suppress the immune system, which can put people with COPD at risk for secondary infections, most commonly NTHi bacterial infections.
“Our biggest concern with patients who have COPD is bacterial infections, which often put their lives at risk,” says Richard Phipps, Ph.D. professor of Environmental Medicine and director of the URSMD Lung Biology and Disease Program. “If we can figure out how to predict who is likely to get an infection, physicians could put them on a preventative medication.”
In his recent study, which was featured in the top ten percent of the March 15 issue of The Journal of Immunology, Phipps and lead author, Amanda Croasdell, a graduate student in the Toxicology program, tested the effectiveness of an inhalable omega-3 derivative to prevent NTHi lung infections in mice.Read More: Omega 3 Fatty Acids May Reduce Bacterial Lung Infections Associated with COPD
The Brain’s Gardeners: Immune Cells ‘Prune’ Connections Between Neurons
Monday, March 7, 2016
Microglia (green) with purple representing the P2Y12 receptor which the study shows is a critical regulator in the process of pruning connections between nerve cells.
A new study out today in the journal Nature Communications shows that cells normally associated with protecting the brain from infection and injury also play an important role in rewiring the connections between nerve cells. While this discovery sheds new light on the mechanics of neuroplasticity, it could also help explain diseases like autism spectrum disorders, schizophrenia, and dementia, which may arise when this process breaks down and connections between brain cells are not formed or removed correctly.
“We have long considered the reorganization of the brain’s network of connections as solely the domain of neurons,” said Ania Majewska, Ph.D., an associate professor in the Department of Neuroscience at the University of Rochester Medical Center (URMC) and senior author of the study. “These findings show that a precisely choreographed interaction between multiple cells types is necessary to carry out the formation and destruction of connections that allow proper signaling in the brain.”
The study is another example of a dramatic shift in scientists’ understanding of the role that the immune system, specifically cells called microglia, plays in maintaining brain function. Microglia have been long understood to be the sentinels of the central nervous system, patrolling the brain and spinal cord and springing into action to stamp out infections or gobble up dead cell tissue. However, scientists are now beginning to appreciate that, in addition to serving as the brain’s first line of defense, these cells also have a nurturing side, particularly as it relates to the connections between neurons.Read More: The Brain’s Gardeners: Immune Cells ‘Prune’ Connections Between Neurons
The Future of Photonics
Tuesday, February 23, 2016
As hundreds of millions of dollar pour into Rochester to establish the nation's first Photonics Hub, Mark Gruba has a closer look at the technology in a News 8 special report, "The Future of Photonics."
Photonics is the science and technology of generating, controlling and detecting photons, which are particles of light. A display at the Rochester Museum & Science Center houses examples of its many applications. In one, a transmitter converts an audio signal from electrical pulses into light pulses. The laser beam sends that information to the receiver, which converts the light pulses back to electrical pulses and sends them to the speaker for your listening enjoyment.
"We work on optical bio sensors," said Dr. Ben Miller, a researcher at the University of Rochester Medical Center. He's creating a sensor that can detect the presence of hundreds of viruses from a single blood sample, in real time. "We're working to make devices so that you can immediately get that information in the doctor's office," said Dr. Miller.Read More: The Future of Photonics
Hope, Hype, and Wishful Thinking
Monday, February 22, 2016
In a perspective piece appearing in the journal Cell Stem Cell, URMC neurologist Steve Goldman, M.D., Ph.D., lays out the current state of affairs with respect to stem cell medicine and how close we are to new therapies for neurological disorders.
The dawn of stem cell medicine some 25 years ago was greeted with great enthusiasm, particularly by scientists who study diseases in the central nervous system (CNS). Many of the diseases found in the brain and spinal cord are degenerative in nature; meaning that over time populations of cells are lost due to genetic factors, infection, or injury. Because stem cell medicine holds the potential to repair or replace damaged or destroyed cells, scientists have considered these diseases as promising candidates for new therapies.
However, as with other emerging fields of medicine, the race to cures has turned out to be more of marathon than a sprint. While scientists have become very adept at manipulating stem and progenitor cells and understanding the complex choreography of genetic and chemical signals that instruct these cells to divide, differentiate, and proliferate, researchers are still grappling with the challenges of how to integrate new cells into the complex network of connections that comprise the human brain.
Goldman, co-director of the URMC Center for Translational Neuromedicine, takes a sweeping view of where we stand and which CNS diseases may or may not ultimately benefit from future stem cell-based therapies.Read More: Hope, Hype, and Wishful Thinking
Congratulations Dr. Sipe!
Wednesday, February 17, 2016
Make sure you congratulate Grayson Sipe on defending his thesis.
Way to go Grayson!
Richard Aslin's Rochester Baby Lab Shows
Wednesday, February 17, 2016
Amelia Smith sits on the floor of a newly remodeled wing of the University of Rochester's department of Brain and Cognitive Sciences. The 8-month old wears a headband of cottony roses, and tiny bubbles form in the corner of her mouth. She's completely entranced by the commotion around her.
Though few adults in the room can resist oohing and aww-ing, little Amelia is not there to be fawned over. She's there to work. Researchers at the UR's Baby Lab want to know what she's thinking, what she's learned so far in her young life, and how she learned it.
But there's a problem: Amelia can't talk yet.
The work being investigated in Richard Aslin's Baby Lab was written up in the City Newspaper article "Signs of Intelligent Life".Read More: Richard Aslin's Rochester Baby Lab Shows
Tracking Melanoma Metastasis Leads to Key Gene Discovery
Wednesday, February 17, 2016
A Wilmot Cancer Institute investigator discovered a gene that’s required for the initiation of melanoma and the growth of disseminated melanoma cancer cells in the lungs.
The findings suggest that the gene’s signaling pathway may be proof that melanoma stem cells exist, a question that’s being debated by scientists.
Lei Xu, Ph.D., associate professor of Biomedical Genetics at the University of Rochester Medical Center, is lead author of the study, which was recently published in PLOS ONE and funded by a Wilmot Cancer Institute pilot grant. The Xu lab investigates the multiple, complex steps that occur as cancer cells spread from the original tumor to other parts of the body.
Read More: Tracking Melanoma Metastasis Leads to Key Gene Discovery
Report Recommends More Treatment, Research, for Gulf War Vets
Monday, February 15, 2016
The cause of Gulf War illness is still a mystery but focusing on treatments and interventions might help the veterans of Operation Desert Storm as well as the troops of the future, according to an Institute of Medicine committee report led by University of Rochester Medical Center Professor Deborah Cory-Slechta.
In 1990 and ’91 nearly 700,000 U.S. troops deployed to the Persian Gulf region for a short, intense war. Few injuries or deaths occurred, but troops were exposed to chemical and biological weapons, vaccines, oil-fires, air pollution, bomb blasts, pesticides, extreme desert temperatures, and constant false alarms and fear of nerve-gas attacks.
After the war ended a high number of the veterans reported debilitating fatigue, muscle and joint pain, headaches, and cognitive problems. This became known as “Gulf War illness.” During the past 25 years, 10 different committees of the nation’s top medical experts have searched for evidence that would better define Gulf War illness and possible treatments. The latest committee, headed by Cory-Slechta, concluded that no single mechanism can explain the multitude of symptoms seen in Gulf War illness—and that it’s unlikely a cause will ever be identified.Read More: Report Recommends More Treatment, Research, for Gulf War Vets
Doing something larger than you could ever do on your own
Friday, February 12, 2016
"There is a tendency for many investigators, especially early in their careers, to hold onto their work and not share it," says David Williams, the William G. Allyn Professor of Medical Optics; Dean for Research in Arts, Sciences and Engineering; Director of the Center for Visual Science - and a leading eye expert who pioneered the use of adaptive optics for vision correction.
"They don't realize - and it's one of the things that took me longer to learn than I wish it had - that one of the best ways to build your reputation is to share your ideas or your technology with the hope that they will be adopted.
"I was lucky enough to realize that if I let my students take my adaptive optics technology and use it to build their own labs, for example, it not only helped them get their independent research programs off the mark but also enhanced my reputation because so many more people were able to access and deploy the technology."
Is it any wonder then, that of the five NEI Audacious Goals grants recently awarded to Williams and four other investigators:
- four of the projects use adaptive optics as their core technology?
- three of the other PI's are either current collaborators with Williams or former postdocs in his lab?
- which means that four of the PI's will be cooperating with each other, even as they individually collaborate with other experts in the field on their individual projects - in effect widening the opportunities for synergy?
"That's the excitement of this," Williams says. "Why should we compete when one group can do one piece of it, and a second group can do another, and as along as you can manage authorships and credit appropriately and fairly, we can be much more efficient and effective in getting things done?"
"One of the things I'm proudest about in this community of people around the world doing adaptive optics and retinal imaging is that almost all of us get along really well, and we're moving science forward as rapidly as we can by helping each other. That doesn't always happen in science."
As Dean of Research for Arts, Science and Engineering, Williams is always looking for young faculty throughout AS&E who have the right personality and vision to take on larger, multi-investigator, multi-institutional projects.
"You have to be gregarious and interested in working with other people and tolerating the quirks that they have, just as they have to tolerate the quirks you have," Williams said.
"The largest source of optimism for me about the AS&E research portfolio is the quality of our junior faculty members - their enthusiasm and energy. Many of them have cut their teeth on individual investigator awards and will reach a certain point in mid career when they realize they need to reach out for complementary expertise in order to do more."
Williams' advice: The best collaborator may not be the first one that comes to mind.
"One of the biggest mistakes faculty members make is to choose a collaborator who is just like them, who has the same interests in a problem and the same background and who they can easily begin a conversation with because they are so closely aligned. But that doesn't really help your research. You want to have somebody who . . . has a completely different skills set. As obvious as that is, it doesn't always get factored into planning how to accumulate the necessary wisdom to do something larger than you could ever do on your own."
Scientists Seek to Improve Flu Vaccine for the Very Young
Thursday, February 11, 2016
Scientists at the University of Rochester School of Medicine and Dentistry have discovered a way to make a nasal spray flu vaccine safer for those who are at greatest risk of catching the flu, particularly infants under the age of 2. The work is early and a long way from being applied in people, but offers promise for a vaccine that could better protect the most vulnerable.Read More: Scientists Seek to Improve Flu Vaccine for the Very Young
Study Sheds Light on Source of Drug Addicts' Risk-Taking Behavior
Wednesday, February 10, 2016
A study out today provides new insight into how the brains of drug addicts may be wired differently. The findings, which appear in the journal Psychopharmacology, show that while drug users have very strong motivation to seek out "rewards," they exhibit an impaired ability to adjust their behavior and are less fulfilled once they have achieved what they desire. Addressing this disconnect between the craving for a drug and the ability to regulate behavior may be one of the keys to breaking the cycle of addiction.
"The vast majority of people, when faced with something they want, will assess how achievable the goal is and adjust their actions and expectations in order to maximize their potential to achieve it," said John Foxe, PhD, the chair of the Department of Neuroscience at the University of Rochester Medical Center and senior author of the study. "However, it appears that the integrity of this system of assessment and self-regulation is impaired in substance abusers and this may contribute to the risk-taking behaviors and poor decision-making commonly associated with this population."Read More: Study Sheds Light on Source of Drug Addicts' Risk-Taking Behavior
Lead poisoning still an issue in Rochester
Tuesday, February 9, 2016
The Michigan city of Flint became ground zero of the nation's latest public-health outrage when it was learned in recent months that its tap water contained unsafe levels of toxic lead.
Though the aqueous cause of its lead problem is unusual, Flint is otherwise far from unique. Many American cities, including Rochester, continue to struggle with lead poisoning, particularly of children.
In fact, despite years of successful anti-lead work locally, the proportion of children in Rochester found to have elevated levels of lead in their blood still was roughly double that of their counterparts in Flint in 2014, the most recent year for which comparable data are available.
Read More: Lead poisoning still an issue in Rochester
We have had a huge amount of progress here. We’ve had a nearly 90 percent reduction in the number of kids with elevated blood lead levels in the past 15 years, said Katrina Smith Korfmacher, an associate professor of environmental medicine at the University of Rochester Medical Center who has long been involved in local anti-lead efforts.
But I would say it’s still a serious, or an ongoing, problem. The point is, it won’t ever go away entirely, because there is lead in the environment.
Scientists Discover Stem Cells Capable of Repairing Skull, Face Bones
Monday, February 1, 2016
The photo shows a blue-stained stem cell and a red-stained stem cell that each generated new bones cells after transplantation.
A team of Rochester scientists has, for the first time, identified and isolated a stem cell population capable of skull formation and craniofacial bone repair in mice—achieving an important step toward using stem cells for bone reconstruction of the face and head in the future, according to a new paper in Nature Communications.
Senior author Wei Hsu, Ph.D., dean’s professor of Biomedical Genetics and a scientist at the Eastman Institute for Oral Health at theUniversity of Rochester Medical Center, said the goal is to better understand and find stem-cell therapy for a condition known as craniosynostosis, a skull deformity in infants. Craniosynostosis often leads to developmental delays and life-threatening elevated pressure in the brain.
Hsu believes his findings contribute to an emerging field involving tissue engineering that uses stem cells and other materials to invent superior ways to replace damaged craniofacial bones in humans due to congenital disease, trauma, or cancer surgery.
For years Hsu’s lab, including the study’s lead author, Takamitsu Maruyama, Ph.D., focused on the function of the Axin2 gene and a mutation that causes craniosynostosis in mice. Because of a unique expression pattern of the Axin2 gene in the skull, the lab then began investigating the activity of Axin2-expressing cells and their role in bone formation, repair and regeneration. Their latest evidence shows that stem cells central to skull formation are contained within Axin2 cell populations, comprising about 1 percent—and that the lab tests used to uncover the skeletal stem cells might also be useful to find bone diseases caused by stem cell abnormalities.
The team also confirmed that this population of stem cells is unique to bones of the head, and that separate and distinct stem cells are responsible for formation of long bones in the legs and other parts of the body, for example.
The National Institutes of Health and NYSTEM funded the research.
Read More: Scientists Discover Stem Cells Capable of Repairing Skull, Face Bones
Strong Star Certificate of Appreciation Awarded to Dr. Jermaine “JJ" Jenkins
Tuesday, January 26, 2016
On January 22, 2016, Dr. Jermaine Jenkins, who runs the Structural Biology and Biophysics Facility, was nominated for going 'above and beyond' in his work for a client of the facility. The client commented in their nomination:
The clinical trials group had a very tight timeline to meet for one of our clients. Testing had to be completed by the 25th of January so the client could present the data to the FDA. JJ was aware of the required quick turnaround time and he met the challenge. He worked the weekend so that our client's needs would be met. It is so impressive to work with such a dedicated scientist who takes his job so seriously. With JJ's help, URMC Labs Clinical Trials group made a very good impression on a client.
As Facility Manager of the Structural Biology and Biophysics Facility, Dr. Jenkins offers support services to determine macromolecular x-ray crystal structures, and to investigate protein-protein, protein-nucleic acid or protein-small molecule interactions. Professor Clara Kielkopf – a long time user and co-founder of the Facility commented,
JJ quickly, calmly and reliably responds to user needs. Co-director of the Facility Professor Joseph Wedekind added,
Dr. Jenkins is an outstanding and dedicated scientist. We are fortunate to have such a great colleague. Please join us in expressing your gratitude to JJ for his service and dedication.
CTSI Trainee Pilot supports better understanding of lupus
Friday, January 15, 2016
Lupus is a devastating disease that affects around 1 in 2,000 people in the U.S., and involves chronic inflammation and tissue damage in various organs including the skin, kidneys, and joints. Although the mortality rate for lupus has improved in recent decades, a diagnosis of lupus often means elevated risk of early mortality and lifetime of immunosuppressive therapy, which can carry significant side effects.Read More: CTSI Trainee Pilot supports better understanding of lupus
The Scientist as Storyteller
Friday, January 15, 2016
Graduate students Clarence Ling (left), Jon Baker,
and Karl Smith rehearse a script for The Bootleggers
at the WRUR studios in Todd Union. (Photo: Adam Fenster)
For Karl Smith, the storytelling bug began with a Montgomery Ward No. 22 typewriter purchased for $5 at a moving sale.
Typewriter perched on his lap, the doctoral student in biophysics has become a fixture at the Rochester Public Market, Corn Hill Arts Festival, and other Rochester-area arts-oriented venues. For 10 cents, he crafts a half-sheet-long tale about grandchildren, lost loves, pets, or the absurd. The clacking of keys on paper draws a curious crowd.
I derive a lot of meaning and joy from making things that other people draw joy from, says Smith.
As a graduate student at Rochester, Smith has been finding lots of ways to share his love of storytelling. In addition to his peripatetic typewriting, he’s the leader of Rocket Radio Theater, a troupe of radio performers whose core membership includes fellow like-minded medical science graduate students Clarence Ling, Jon Baker, Carolyn Klocke, Bronwyn Lucas, and Matt Payea.
The project began in 2013 with a recording at Smith’s kitchen table. The group, which now records in the studios of campus radio station WRUR, hosts several serial drama podcasts and stand-alone stories created by Smith. Its feature series, The Bootleggers, takes place during prohibition-era Rochester, playing up aspects of local history and landscapes.
In his research as a biophysicist, Smith explores nanoporous silicon membranes in the lab of James McGrath, professor of biomedical engineering. Smith describes the membranes as
coffee filters made of glass that are 10,000 times thinner than a human hair.
But he hopes to continue to combine storytelling and science after graduation, perhaps as a science journalist or a podcaster.
Read More: The Scientist as Storyteller
I want to live in a world, he says,
where people are standing on street corners writing stories.
What Frogs Can Teach Us About Tumors
Wednesday, January 13, 2016
Researchers at the University of Rochester School of Medicine and Dentistry are using frogs as a model to study human diseases. These frogs, called South African clawed frogs or Xenopus laevis, may not resemble humans on the outside, but they are very similar on a genetic level.Read More: What Frogs Can Teach Us About Tumors
Toxic Chemicals May Weaken Infants' Response to TB Vaccine
Friday, December 18, 2015
Exposure to toxic chemicals while in the womb or in early life may weaken a baby's immune system response to the tuberculosis (TB) vaccine, researchers say.
The study focused on two common toxins: PCBs, an industrial chemical; and DDT, used in pesticides. These so-called "persistent" pollutants are not easily broken down and remain a health threat years after being banned.
PCBs were banned in the United States in 1979. DDT is banned in the United States, but is still used in some countries to control malaria-carrying mosquitoes, the study authors, from the University of Rochester in New York, said in a university news release.
"There are thousands of pollutants similar to PCBs and DDT with unknown health implications," study leader Dr. Todd Jusko, assistant professor in the departments of environmental medicine and public health services, said in the news release. "Our work provides a foundation for how these types of chemicals affect the developing immune system in infants around the world."
Read More: Toxic Chemicals May Weaken Infants' Response to TB Vaccine
Exposure to chemicals lowers babies' TB vaccine response
Wednesday, December 9, 2015
Fetal exposure to two chemicals -- polychlorinated biphenyls, or PCBs, and DDE, a product of the breakdown of the insecticide DDT -- can dampen infants' immune response to the tuberculosis vaccine, according to a new study of mothers and children.
Both chemicals have been banned in many countries, including the United States, but are considered persistent pollutants, which pose health risks long after being introduced into the environment, can accumulate. The effects of such pollutants can pass between species through the food chain.
PCBs were used in manufacturing and consumer products in the United States until 1979, but most people have detectable PCB concentrations in their blood. DDT was banned in the United States in 1972, though many countries still use it to control the spread of malaria by mosquitoes.
Read More: Exposure to chemicals lowers babies' TB vaccine response
There are thousands of pollutants similar to PCBs and DDT with unknown health implications, said Dr. Todd Jusko, an assistant professor at the University of Rochester, in a press release.
B&B Professor Harold Smith and Oyagen's Drug Development Highlighted on Local TV for World Aids Day
Friday, December 4, 2015
OyaGen, a small medical research firm off Jefferson Road in Henrietta, has used federal grants for its HIV drug discovery programs with the goal of finding a cure. Dr. Harold Smith, Professor of Biochemistry & Biophysics at the University of Rochester, and the company's founder, president and CEO got his start as a molecular biologist studying heart disease.
"It became clear to me that the things we were doing to study heart disease and find out why things were happening translated directly into the HIV research arena," Smith said.
By 2010, things kicked into high gear. Advanced robotics were added allowing scientists to work with advanced chemistries. They've now identified a weak point in the HIV virus that's never been exploited before. Vif is a viral defense HIV releases into cells it infects. It destroys the body's natural defense against infections. OyaGen discovered a way to defeat HIV by disabling Vif.
"If we can proceed along track, we will be looking at entering clinical trials within a completely different way of approaching the virus and the disease within three years," Smith said.
To read more see the Channel 8 story.
Gloria Culver to Be Installed as Dean
Tuesday, December 1, 2015
Former Biochemistry graduate student and current Chair of Biology, Dr. Gloria Culver, will be formally installed as dean of the School of Arts & Sciences during an investiture ceremony at 4 p.m. today in the Interfaith Chapel on the River Campus.
University Trustee Ani Gabrellian ’84 will provide opening remarks, followed by words from Provost Peter Lennie, the Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences & Engineering. Mariette Westermann, vice president of the Andrew W. Mellon Foundation, and Jon Lorsch, director of the National Institute of General Medical Sciences, will serve as guest speakers. Following the ceremony, a reception will be held in the Hawkins-Carlson Room of Rush Rhees Library. Read More: Gloria Culver to Be Installed as Dean
Study Provides New Insight on Stem Cell Function
Tuesday, December 1, 2015
Researchers in the Department of Biomedical Genetics have unraveled one of the key molecular mechanisms that regulate stem cell behavior, a discovery that could provide important insight into regenerative medicine and certain forms of cancer.
The study – led by Benoit Biteau, Ph.D. – appears in the journal Cell Reports, and was conducted in fruit flies, or drosophila. While diminutive in stature, fruit flies have proven to be an invaluable research tool and have made oversized contributions to medicine, particularly in the fields of molecular biology and genetics.
Benoit and his colleagues focused on a transcription factor called Sox21a which is uniquely found in the stem cells of the drosophila intestine. Transcription factors are proteins that control the expression of genes and, subsequently, help regulate cellular activity. Sox21a is the equivalent of Sox2, a transcription factor found in humans that is known to play an important role in the function of stem cells and cell reprogramming.
Read More: Study Provides New Insight on Stem Cell Function
Anna Bird Receives Two Awards
Thursday, November 19, 2015
Anna Bird has received the Randy N. Rosier Award for public speaking ($1000 in travel funds received at the URMC CMSR Symposium 2015) and the American Association of Immunologists (AAI) Trainee Abstract Award ($750 in travel funds for AAI New Orleans Conference, 2015).
NASA Grant Will Explore Impact of Space Travel on the Brain
Friday, November 13, 2015
Kerry O'Banion, M.D., Ph.D., has been awarded $1.8 million from NASA to study whether extended deep space travel places astronauts at risk for neuro-degenerative diseases like Alzheimer's.
The grant is one of nine announced by NASA that will fund research that employ beams of high-energy, heavy ions simulating space radiation. The studies will be conducted in part at the NASA Space Radiation Laboratory at Brookhaven National Laboratory on Long Island. By colliding matter together at very high speeds, the accelerators at Brookhaven can reproduce the radioactive particles found in space.
The studies will seek to better understand and reduce the risks to humans associated with long journeys in deep space, specifically focusing on neurological and cardiovascular diseases and cancer. Understanding the potential health impact of space travel is a priority for NASA as it develops future plans for maned voyages to Mars and other destinations.Read More: NASA Grant Will Explore Impact of Space Travel on the Brain
UR Scientist Wins Novo Nordisk Award to Develop Obesity Drug
Wednesday, November 11, 2015
University of Rochester Medical Center researcher Richard P. Phipps, Ph.D., won a top scientific award from the pharmaceutical giant Novo Nordisk, to collaborate on a new obesity therapy based on his laboratory’s discoveries.
Phipps, the Wright Family Research Professor of Environmental Medicine, is the first UR faculty to receive the competitive Novo Nordisk Diabetes and Obesity Biologics Science Forum Award. The drug company is providing substantial financial support for the two-year project, which is designed to quickly move basic science in diabetes and obesity to an early stage of drug development known as proof-of-principle.
Phipps discovered a new function for a protein known as Thy1 (formally called CD90), linking it to fat cell accumulation.Read More: UR Scientist Wins Novo Nordisk Award to Develop Obesity Drug
Nguyen Mai Wins Poster Competition at 2015 APSA/Tri-Institutional MSTP Conference
Monday, November 9, 2015
Congratulations to Nguyen Mai for winning first place for the poster competition at the 2015 APSA/Tri-Institutional MSTP Conference at SUNY Upstate in Syracuse, NY.
Study: Brain's Immune System Could Be Harnessed to Fight Alzheimer's
Wednesday, November 4, 2015
A new study appearing in the Journal of Neuroinflammation suggests that the brain’s immune system could potentially be harnessed to help clear the amyloid plaques that are a hallmark of Alzheimer’s disease.
This research confirms earlier observations that, when activated to fight inflammation, the brain's immune system plays a role in the removal of amyloid beta, said M. Kerry O'Banion, M.D., Ph.D., a professor in the University of Rochester Department of Neurobiology and Anatomy, the Del Monte Neuromedicine Institute, and the lead author of the study.
We have also demonstrated that the immune system can be manipulated in a manner that accelerates this process, potentially pointing to a new therapeutic approach to Alzheimer's disease.
The findings are the culmination of years of investigation that were triggered when O'Banion and his colleagues made a surprising discovery while studying mouse models of Alzheimer's disease. They observed that amyloid beta plaques – which scientists believe play a major role in the disease – were being cleared in animals with chronic brain inflammation.
For more information, visit the URMC NewsroomRead More: Study: Brain's Immune System Could Be Harnessed to Fight Alzheimer's
Congratulation Fatima Rivera-Escalera
Monday, November 2, 2015
Fatima has successfully defended her PhD thesis.
Congratulations Dr. Rivera-Escalera!!!
Congratulations to Monique Mendes, 1st year NGP student!
Friday, October 30, 2015
Monique was recognized at the 2014 Annual Biomedical Research Conference for Minority Students (ABRCMS) for an outstanding poster/ oral presentation and was awarded an AHA/ASA Travel Award. This award is given to recognize promising and outstanding investigators in the early stages of their careers, and provide travel assistance to participate in the upcoming 2015 Scientific Sessions.
Scientific Sessions is the American Heart Association's largest gathering of scientists and healthcare professionals devoted to the science of cardiovascular disease and stroke and the care of patients suffering from these diseases. It is the leading cardiovascular meeting in the country with over 17,000 professionals attending annually, and over 22,000 total attendees. Programming for this meeting is designed to improve patient care by communicating the most timely and significant advances in prevention, diagnosis and treatment of cardiovascular disease from many different perspectives. Sessions provides five days of comprehensive, unparalleled education through more than 4,000 presentations given by some of the world's top leaders in the areas of cardiovascular disease, as well as a chance to experience more than 300 exhibitors showcasing the latest cardiovascular technology and resources.
This year's Scientific Sessions will be held November 7th - 11th in Orlando, FL
What We Hear, Even Subconsciously, Fine Tunes Our Sense of Distance
Friday, October 30, 2015
Most of us at one time or another have counted the seconds between a lightning flash and its thunder to estimate distance. University researcher Duje Tadin and his colleagues have discovered that humans can unconsciously notice and make use of sound delays as short as 40 milliseconds (ms) to fine tune what our eyes see when estimating distances to nearby events.
Much of the world around us is audiovisual, says Tadin, Associate Professor of Brain and Cognitive Sciences and senior author of the study.
Although humans are primarily visual creatures, our research shows that estimating relative distance is more precise when visual cues are supported with corresponding auditory signals. Our brains recognize those signals even when they are separated from visual cues by a time that is too brief to consciously notice.
For the study, published in PLOS ONE, researchers used projected three-dimensional (3D) images to test the human brain's ability to use sound delays to estimate the relative distance of objects.
For the entire story, visit the Univ. Rochester Newscenter.Read More: What We Hear, Even Subconsciously, Fine Tunes Our Sense of Distance
Lynne Maquat Receives Canada’s Top Prize for Biomedical Research
Thursday, October 29, 2015
On October 29, Dr. Lynne E. Maquat received a 2015 Canada Gairdner International Award, for her work discovering and elucidating the mechanism of mRNA decay pathways. Dr. Maquat was accompanied during presentation of the award by University of Rochester President Joel Seligman, Dean Mark Taubman, and the US Ambassador to Canada, Bruce Heyman (see photo). The sold out annual black tie gala took place at the Royal Ontario Museum in Toronto, Canada and was attended by members of the health care, academic, private and public sectors (additional pictures here). Among the attendees were Nobel Laureate Dr. Phillip Sharp, His Excellency the Right Honourable David Johnston, Governor General of Canada, and the Swiss and Japanese Ambassadors to Canada, who accompanied recipients of the Canada Gairdner International Award from those countries.
Leading up to this event, Dr. Maquat visited four local universities where she spoke to high school students about her personal story of how she became interested in research and what she hopes to achieve through her work. She also met with post-docs and graduate students at each university as well as speaking to faculty members about their research. Following the gala, Dr. Maquat attended and spoke at a 2015 Gairdner Symposium
RNA and The New Genetics at the University of Toronto, which she helped coordinate. Her last event occurred at the University of New Brunswick, Fredericton where she once again spoke to high school students
On being a Scientist: Uncovering the mysteries of life and met with post-docs and graduate students about their research. Dr. Maquat took every opportunity to be part of the National Program, where the goal of these programs is
to contribute to Canadian science culture and innovation, and to be part of the Student Outreach Programs where she helped realize one of the Gairdner Foundation’s missions
to inspire young people to consider a career in science, and to increase their awareness of the value of scientific research.
Sigma Xi awards David R. Williams the William Procter Prize for Scientific Achievement
Monday, October 26, 2015
David R. Williams, widely regarded as one of the world’s leading experts on human vision, has been named the recipient of Sigma Xi’s 2015 William Procter Prize for Scientific Achievement. The prize is given annually since 1950 in recognition of
outstanding achievement in scientific research and demonstrated ability to communicate the significance of this work to scientists in other disciplines. Past Procter Prize recipients have included Jane Goodall, Vannevar Bush, Margaret Mead, Murray Gell-Mann, and Rita Colwell.
He will be presented the Procter Prize at an evening ceremony on Saturday, Oct. 24 in Kansas City, during the scientific research society Sigma Xi’s annual meeting.
For the entire article, visit the Rochester NewsCenter.Read More: Sigma Xi awards David R. Williams the William Procter Prize for Scientific Achievement
URMC using photon laser for cancer research
Saturday, October 24, 2015
Edward Brown's research is a mixture of photonics, microscopes and a little nudge from his mom.
Brown, who teaches biomedical engineering at the University of Rochester Medical Center, has built a laser-and-microscope device to study how likely cancer cells will spread throughout the body. Specifically, he's looking at how likely cancer cells have spread inside breast cancer patients who already have had the tumor removed.
Learning more about the cell movement, called metastasis, is key to a larger overtreatment problem that Brown is trying to fix.
When patients first realize they have breast cancer, it's unclear whether the cancer cells have spread, so doctors recommend chemotherapy as a precaution. However, Brown and other medical researchers believe patients are being overtreated because doctors are giving chemo to patients who may not need it.Read More: URMC using photon laser for cancer research
Clerio Vision licenses ground-breaking approach to vision correction developed by Huxlin, Knox and Ellis
Friday, October 23, 2015
LASIK revolutionized vision correction in the 1990s. Now, a new technology arising from research conducted by Wayne Knox, Professor of Optics and Physics; Krystel Huxlin, Professor of Ophthalmology; and Jonathan Ellis, Assistant Professor of Mechanical Engineering, may do the same, notes UR Ventures Technology Review.
LIRIC (Laser Induced Refractive Index Change), this ground-breaking method also uses a laser to correct the optical properties of the eye, but that's where the similarities to LASIK end.
The older technology uses two lasers and includes cutting the cornea to create a flap and then pulling that flap back to expose the inner cornea. A laser is then applied to ablate and reshape the corneal tissue to achieve the desired focus. The corneal flap is repositioned and the healing process begins. Complications are rare, but as with any surgery, are a concern. Fear of complications and of having one's eye cut are big reasons why less than 2 percent of people who are eligible for LASIK undergo the procedure.
The LIRIC method uses a laser at a much lower power and does not cut or remove any tissue. Instead, it is a non-invasive procedure that alters the refractive index of the corneal tissue to correct vision. Since the procedure doesn't thin the cornea like LASIK, it may be repeated many times over the course of a patient's lifetime as the eye grows and changes.
This technology has been licensed to Clerio Vision, Inc., a local startup poised to bring this new treatment to market. Clerio was started by a team of entrepreneurs with proven track records - Mikael Totterman (VirtualScopics, iCardiac), Alex Zapesochny (Lenel, iCardiac), Scott Catlin (AMO, Abbott Medical Optics - and now with UR Ventures), and Sasha Latypova (VirtualScopics, iCardiac). The company successfully concluded an oversubscribed Series A round of fundraising with participation from three venture capital firms, and is considering a Series B round to further accelerate product and clinical development. They have proven efficacy in animal models and hydro-gels (contact lenses), and plan to conduct human studies early in 2016.
Taylor Moon and Kyle Koster Receive Awards at Local Meetings
Thursday, October 22, 2015
Congratulations to Taylor Moon and Kyle Koster for their award-winning presentations at two local scientific meetings. Taylor received the "Excellence in Scientific Presentation" award at the Department of Microbiology and Immunology Retreat on October 6th 2015. Kyle received the second place award for his poster at the American Physician Scientists Association Northeast Regional Meeting in Syracuse October 17th 2015. Taylor and Kyle are Microbiology and Immunology doctoral students in the Elliott Lab in the Center for Vaccine Biology and Immunology.
Experimental Treatment Regimen Effective Against HIV
Monday, October 19, 2015
Protease inhibitors are a class of antiviral drugs that are commonly used to treat HIV, the virus that causes AIDS. Scientists at the University of Nebraska Medical Center designed a new delivery system for these drugs that, when coupled with a drug developed at the University of Rochester School of Medicine and Dentistry, rid immune cells of HIV and kept the virus in check for long periods. The results appear in the journal Nanomedicine: Nanotechnology, Biology and Medicine.
While current HIV treatments involve pills that are taken daily, the new regimens' long-lasting effects suggest that HIV treatment could be administered perhaps once or twice per year.
Nebraska researcher Howard E. Gendelman designed the investigational drug delivery system–a so–called
nanoformulated protease inhibitor. The nanoformulation process takes a drug and makes it into a crystal, like an ice cube does to water. Next, the crystal drug is placed into a fat and protein coat, similar to what is done in making a coated ice–cream bar. The coating protects the drug from being degraded by the liver and removed by the kidney.
When tested together with URMC–099, a new drug discovered in the laboratory of UR scientist Harris A. (Read More: Experimental Treatment Regimen Effective Against HIV
Handy) Gelbard M.D., Ph.D., the nanoformulated protease inhibitor completely eliminated measurable quantities of HIV. URMC–099 boosted the concentration of the nanoformulated drug in immune cells and slowed the rate at which it was eliminated, thereby prolonging its therapeutic effect.
Ann Dozier Inducted into American Academy of Nursing
Thursday, October 1, 2015
October 2015. Ann Dozer, Ph.D. was selected as one of 163 nurse leaders to be inducted as a fellow in the American Academy of Nursing for 2015. Academy fellows represent all 50 states, District of Columbia, and 24 countries and include government and hospital administrators, college deans, and renowned scientific researchers.
Barbara Iglewski to Be Inducted into Women's Hall of Fame
Thursday, October 1, 2015
Barbara Iglewski, professor emeritus in the Department of Microbiology and Immunology, will be inducted into the National Women's Hall of Fame this weekend. She is the third faculty member to be enshrined in Seneca Falls: Judith Pipher, professor emeritus of physics and astronomy, and Loretta Ford, founding dean of the School of Nursing, were inducted in 2007 and 2011, respectively.Read More: Barbara Iglewski to Be Inducted into Women's Hall of Fame
Sneak Peak of The Brain with Dr. David Eagleman at The Little Theater Followed by Panel Discussion Featuring Liz Romanski
Monday, September 28, 2015
The Brain with Dr. David Eagleman
Wed, 09/30/2015 - 7:00pm - 9:00pm
Join WXXI for a special preview screening of a new series that tells the story of the inner workings of the brain.
The Brain with Dr. David Eagleman, a new six one-hour series that explores the human brain in an epic series that reveals the ultimate story of us,
why we feel and think the things we do, premieres on WXXI-TV in October 14th. But before it does, you can enjoy a sneak preview of the series on
the big screen at The Little Theater (240 East Avenue) on Wednesday, September 30 at 7 p.m. The event is free, but seats are first come first served.
WXXI is pleased to partner with the Rochester Museum & Science Center to bring you this screening, followed by a panel discussion featuring Liz.
For further information, please visit the WXXI website.
Read More: Sneak Peak of The Brain with Dr. David Eagleman at The Little Theater Followed by Panel Discussion Featuring Liz Romanski
NSC Student Humberto Mestre M.D. Awarded Travel Grant to SFN 2015
Sunday, September 20, 2015
Humberto Mestre, M.D.
In 2014, Humberto was selected for the Latin America Training Program by the Society for Neuroscience and the International Brain Research Organization.
This program was formerly known as the Ricardo Miledi Neuroscience Training Program. The Program allowed 15 young scientists from Latin America and the Caribbean to attend a three week course where top faculty from across the region and North America provided the young scientists with lectures, lab exercises using cutting edge techniques, and training on vital professional development topics - one speaker was Dr. Deborah Cory-Slechta.
The completion of the year-long participation culminated with a travel grant to attend the Society for Neuroscience Meeting 2015 in Chicago, IL and to present science at the International Fellows Poster Session to be held on Saturday, October 17 from 6:30 pm-8:30 pm in Hall A of McCormick Place.
Read More: NSC Student Humberto Mestre M.D. Awarded Travel Grant to SFN 2015
Wilmot Cancer Institute’s Research Director Wins $6.3M Outstanding Investigator Award
Thursday, September 17, 2015
Hartmut “Hucky” Land, Ph.D., the Robert and Dorothy Markin Professor of Biomedical Genetics at the University of Rochester, received a newly established multimillion dollar award from the National Cancer Institute that supports exceptional scientists with seven years of uninterrupted funding.
The NCI Outstanding Investigator Award (OIA) is in its inaugural year. It was designed to reward productive and influential researchers by giving them the freedom to pursue long-term goals without having to re-submit grants each cycle. He will continue to test a bold hypothesis that’s been the cornerstone of his work for 30 years—that different cancers have many shared features, and understanding the common characteristics of cancer might unlock the next generation of targeted treatments.
“I feel very grateful and a bit humbled,” said Land, director of research and co-director at UR Medicine’s Wilmot Cancer Institute. “It’s a wonderful affirmation of our focus on the common core of cancers and the work of our research team.”Read More: Wilmot Cancer Institute’s Research Director Wins $6.3M Outstanding Investigator Award
NB&A Faculty take honors at Convocation 2015
Thursday, September 10, 2015
- Ania Majewska PhD - Outstanding Graduate Program Director
- John Olschowka PhD - 1st Year Teaching Special Commendation
- Martha Gdowski PhD - Gold Medal Teaching Award
- Nina Schor MD, PhD - Faculty Academic Mentoring Award
2015 Awards Announced
Tuesday, September 8, 2015
MELVILLE A. HARE AWARD FOR EXCELLENCE IN GRADUATE RESEARCH (MBI): Denise Skrombolas and Benson Cheng
MELVILLE A. HARE AWARD FOR EXCELLENCE IN GRADUATE TEACHING (MBI): Jennifer Colquhoun
OUTSTANDING GRADUATE STUDENT TEACHER: Jim Miller, Ph.D.
EXCELLENCE IN POSTDOCTORAL MENTORING: Luis Martinez-Sobrido, Ph.D.
GRADUATE ALUMNI AWARD: Deborah Fowell, Ph.D.
OUTSTANDING T32 PROGRAM DIRECTOR: Stephen Dewhurst, Ph.D.
FIRST YEAR EXCELLENCE IN TEACHING: Constantine Haidaris, Ph.D.
FACULTY MENTORING AWARD FOR BASIC SCIENCE: Minsoo Kim, Ph.D.
SPECIAL COMMENDATION FOR FIRST YEAR TEACHING: John Frelinger, Ph.D.
OUTSTANDING POSTDOCTORAL MENTOR AWARD: Aitor Nogales Gonzalez, Ph.D.
OUTSTANDING POSTDOCTORAL RESEARCHER AWARD: Eva-Stina Edholm, Ph.D.
Immune Cells Take Cue from Animal Kingdom: Together, Everyone Achieves More
Friday, September 4, 2015
Much like birds fly in flocks to conserve energy, dolphins swim in pods to mate and find food, and colonies of ants create complex nests to protect their queens, immune cells engage in coordinated behavior to wipe out viruses like the flu. That’s according to a new study published in the journal Science by researchers at the University of Rochester School of Medicine and Dentistry.
The findings reveal, for the first time, how immune cells work together to get to their final destination – the site of an injury or infection. The body is expansive and a virus or bacteria can take hold in any number of locations: the lungs, the throat, the skin, the stomach or the ear, just to name a few. How do immune cells, specifically the ones that are responsible for killing foreign invaders, know where to go?
Read More: Immune Cells Take Cue from Animal Kingdom: Together, Everyone Achieves More
EHSC Welcomes Dr. Martha Susiarjo
Tuesday, September 1, 2015
The Environmental Health Sciences Center (EHSC) would like to welcome Dr. Martha Susiarjo to URMC.
Dr. Martha Susiarjo applies her background in epigenetics to understanding whether epigenetic regulation of genes contributes to gene-environment interaction during early development. She joins us as Assistant Professor from the University of Pennsylvania, where she recently completed her postdoc studying environmental estrogens and regulation of imprinted genes (genes contributed by only one parent). Dr. Susiarjo employs a mouse model to understand the mechanism(s) by which environmental exposures – obesogenic endocrine disrupting chemicals in particular – during in utero development can shape the future health outcomes of the offspring. She hopes to identify mechanisms in order to better inform exposure prevention efforts.
Dr. Susiarjo looks forward to collaborating with center members to utilize her expertise in epigenetics, especially DNA methylation, in various models of environmental perturbations. She also hopes collaborative efforts can elucidate how nutritional intervention may provide protective effects on environment-induced developmental outcomes.
Carney lab looks beyond inner ear in quest for better hearing aids
Friday, August 28, 2015
Most hearing aids on the market today are designed to mimic what happens in our inner ear - specifically the amplifying role of the outer hair cells.
However, the lab of Laurel Carney, Professor of Biomedical Engineering,
is studying what happens beyond the inner ear - in the complex network of auditory nerve fibers that transmit the inner ear's electrical signals to the brain, and in the
auditory center of the midbrain, which processes those signals.
Therein lies the key to creating hearing aids that not only make human speech louder but clearer, Carney believes.
An important focus of her research uses a combination of physiological and behavioral studies, and computer modeling, to study the 30,000 auditory nerve fibers on each side of our
brain that transmit electrical signals from the inner ear. Critical to this is the initial
transduction of mechanical energy to electrical signals that occurs in the inner hair cells of the inner ear's organ of Corti.
This is critical for shaping the patterning of responses in the auditory nerves, and the patterning of those responses at this first level, where the signal comes into the brain, has a big effect on the way the mid brain responds to the relatively low frequencies of the human voice, Carney explained.
In people with healthy hearing, the initial transduction results in a wide contrast in how various auditory nerve fibers transmit this information.
The responses of some fibers are dominated by a single tone, or harmonic, within the sound; others respond to fluctuations that are set up by the beating of multiple harmonics, Carney said. In the mid brain,
neurons are capable of assimilating this contrast of fluctuating and nonfluctuating inputs across varying frequencies. They begin the process of parsing out the sounds of speech and any other vocalizations that involve low frequencies. A better understanding of how this process works in the midbrain, Carney believes, could yield new strategies for designing hearing aids.
A lot of people have tried to design hearing aids based just on what is going on in the inner ear, but there's a lot of redundancies in the information generated there. We argue that you need to step back and, from the viewpoint of the midbrain, focus on what really matters. It's the pattern of fluctuations in the auditory nerve fibers that the midbrain responds to. The sort of strategies we're suggesting are not intuitive. The idea of trying to restore the contrast in the fluctuations across different frequency channels has not been tried before. The burden is on us
to prove that it works, she added.
To that end, Carney works closely with Joyce McDonough, Professor of Linguistics,
in exploring how auditory nerve fiber transmissions play a role in coding speech sounds. Her lab also works closely with that of Jong-Hoon Nam, Assistant Professor of Mechanical Engineering and of Biomedical Engineering, whose inner-ear studies were described in this newsletter last week. Carney shares what her lab is learning about the interface of auditory nerve fiber signaling with the brain, and in return,
we try to include in our models a lot of the nonlinear properties of the inner ear that he (Nam) has been working on. By interacting with his lab, we hope to continue to
modernize our model as he discovers more, Carney said.
New patent issued for Professor Hocking
Wednesday, August 26, 2015
The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (US 9,072,706) has recently been assigned to the University of Rochester with inventors Denise C. Hocking, Ph.D. (Pharmacology and Physiology, BME, RCBU) and Daniel Roy, Ph.D. (BME PhD 2012 alumnus). The patent relates to a series of recombinant fibronectin peptide mimetics developed to promote wound repair. The technology falls under a new and exciting class of therapies known as wound biologics. The primary commercial application for this technology is to promote healing of hard-to-heal or chronic wounds, including diabetic, venous, and pressure ulcers, which impose a significant health care burden worldwide. Encouraging results from recent studies indicate that topical application of these fibronectin peptide mimetics to full-thickness excisional wounds in diabetic mice accelerates wound closure and promotes granulation tissue deposition, remodeling, and re-vascularization. Denise Hocking is an Associate Professor of Pharmacology and Physiology and of Biomedical Engineering. Daniel Roy is currently a post-doctoral fellow at the US Army Institute of Surgical Research in San Antonio, TX.
NGP students receive the 2015 Convocation Awards
Wednesday, August 26, 2015
Garrick Salois, 1st year student, is this year's recipient of the Irving L. Spar Fellowship Award.
Humberto Mestre, 1st year student, was awarded the Merritt and Marjorie Cleveland Fellowship.
Holly Beaulac, 1st year student, received this year's Graduate Alumni Fellowship Award.
Jenn Stripay, 5th year student, was selected to receive this year's Outstanding Student Mentor Award.
Congrats to all!
Eric Comeau Awarded AHA Fellowship
Saturday, August 15, 2015
Eric Comeau is the recipient of an American Heart Association Pre-Doctoral Fellowship. The fellowship will support Eric’s project titled “Ultrasound standing wave field technologies for cell patterning and microvessel network formation in vitro and in situ”. Through this project, Eric will advance new ultrasound technologies for tissue engineering applications. Eric is a graduate student in the Department of Biomedical Engineering and is co-mentored by Professor Diane Dalecki (BME) and Professor Denise C. Hocking (Pharmacology and Physiology; BME). Eric is also a student member of the Rochester Center for Biomedical Ultrasound (RCBU).
Vision Expert David Williams Receives the Beckman-Argyros Award
Wednesday, August 12, 2015
David Williams, Ph.D.
$500,000 prize for his transformative breakthrough in vision research
David Williams, widely regarded as one of the world's leading experts on human vision, has been named the 2015 recipient of the Beckman-Argyros Award in Vision Research. Williams pioneered the use of adaptive optics technologies for vision applications. He serves as the William G. Allyn Professor of Medical Optics, director of the Center for Visual Science and dean for research in Arts, Science, and Engineering at the University of Rochester.
The award, bestowed by the Arnold and Mabel Beckman Foundation, rewards an individual who has made transformative breakthroughs in vision research. Williams will receive a total of $500,000, along with a solid gold commemorative medallion.
Read More: Vision Expert David Williams Receives the Beckman-Argyros Award
It's an incredible honor for me to receive this award from the Arnold and Mabel Beckman Foundation, said Williams. He added that one aspect that made this award particularly special is that
it allows our group to take risks.
FDA Approves Tool for Diagnosing Dementia in a Doctor's Office
Monday, August 10, 2015
Dr. Charles Duffy
A small company started by a neuroscientist at the University of Rochester has moved closer to providing doctors with what he says is a simple,
computer-based tool to help detect early signs of Alzheimer's disease or other forms of dementia.
Cerebral Assessment Systems has received marketing approval from the
U.S. Food and Drug Administration for Cognivue, a cognitive-assessment tool that functions somewhat like a video game. A patient can perform the
inexpensive and simple test while a time-strapped primary-care physician tends to other patients. The 10-minute, non–invasive examination can detect
subtle lapses in the brain’s perceptual ability that may signal the early stages of mental decline caused by dementia.
The federal government's approval to market the device comes as Alzheimer's researchers everywhere step up the pursuit for easier and more
inexpensive ways to identify dementia in its earliest stages.
Look, there is a late-life tsunami of late-life cognitive decline coming at us, and health-care providers are standing on the beach,
said Charles J. Duffy, a neurology professor at the University of Rochester Medical Center who
founded the company.
What we are all about is making cognitive care part of primary care.
Read the article from the Washington Post.
Read More: FDA Approves Tool for Diagnosing Dementia in a Doctor's Office
1st Annual Immune Imaging Symposium To Be Held November 7, 2015
Wednesday, August 5, 2015
The Program for Advanced Immune Bioimaging at the University of Rochester will host the 1st Annual Immune Imaging Symposium November 7th, 2015 from 8:30 am – 5pm.
The free symposium will provide a forum where the newest developments in understanding immune function through visualizing immunity ‘in action’ will be shared and discussed. The goal of the symposium is to foster lively scientific discussion, exchange of ideas and future collaborations. We have an exciting program including a distinguished group of international speakers, an interactive poster session and opportunities for oral presentations from students and postdoctoral fellows.
For more information and to register, visit the Immune Imaging Symposium website.
Could Your Sleep Position Help Reduce Alzheimer’s Risk?
Wednesday, August 5, 2015
Researchers at SUNY Stony Brook and The University of Rochester think so.
Sleeping in the lateral, or side position, as compared to sleeping on one’s back or stomach, may more effectively remove brain waste and prove to be an important practice to help reduce the chances of developing Alzheimer’s, Parkinson’s and other neurological diseases, according to researchers at Stony Brook University.
In the paper, “The Effect of Body Posture on Brain Glymphatic Transport,” Dr. Benveniste and colleagues used a dynamic contrast MRI method along with kinetic modeling to quantify the CSF-ISF exchange rates in anesthetized rodents’ brains in three positions – lateral (side), prone (down), and supine (up).
Dr. Benveniste and first-author Dr. Hedok Lee, Assistant Professor in the Departments of Anesthesiology and Radiology at Stony Brook developed the safe posture positions for the experiments. Their colleagues at the University of Rochester, including Lulu Xie, Rashid Deane and Maiken Nedergaard, PhD, used fluorescence microscopy and radioactive tracers to validate the MRI data and to assess the influence of body posture on the clearance of amyloid from the brains.Read More: Could Your Sleep Position Help Reduce Alzheimer’s Risk?
Environmental Medicine News: EHSC Grant Renewal, New Appointment
Wednesday, July 29, 2015
Great news from Environmental Medicine—its Environmental Health Sciences Center (EHSC) core grant was recently renewed for the 41st straight year. The department ushered in the $7.5 million, five-year, EHSC award from the National Institute of Environmental Health Sciences (with a remarkable score of 12). She is also overseeing the setup of EHSC’s new epigenetics core facility. Funding for the Center began in 1975 and has been continuously supported by the NIH for costs related to infrastructure, career development, biostatistics, and to support collaborations across research departments at URMC.
Environmental Medicine also hired a new scientist with an interest in reproductive toxicity and epigenetics, a hot field concerned with investigating the environmental factors (such as the endocrine-disrupting chemical bisphenol A) that cause changes in gene expression across generations. Martha Susiarjo, Ph.D., completed a post-doctoral fellowship at the University of Pennsylvania and will join the UR as an assistant professor Sept. 1. She brings an NIH K99 award and expertise to the new epigenetics core facility.
The EHSC will celebrate 50 years of research with a two-day symposium Sept. 23-24, which will include a Science Café Series at the Pittsford Barnes & Noble, a poster session in Flaum Atrium, and a full slate of presentations at URMC from faculty and local civic leaders. Planning is under way; stay tuned for more details.
Work of Liz Romanski Recognized by the University Research Community
Thursday, July 23, 2015
Researchers Pinpoint Brain's Audiovisual Processing Center
A new study is helping scientists more precisely understand how the brain stitches together sensory information such as sound and images, insight that could shed new light on conditions such as Autism. The research, which appears in the Journal of Neuroscience, identifies an area of the brain in the frontal lobe responsible for working memory and sensory integration.
Work in our laboratory is aimed at understanding how auditory and visual information are integrated since we know this process is crucial for recognizing objects by sight and sound, communicating effectively, and navigating through our complex world, said Lizabeth Romanski, Ph.D., an associate professor in the University of Rochester Department of Neurobiology and Anatomy and co-author of the study.
Read More: Work of Liz Romanski Recognized by the University Research Community
Our recent study demonstrates that the prefrontal cortex plays an essential role in audiovisual working memory, and when this area is switched off our ability to remember both the auditory and visual cues is impaired, said Bethany Plakke, Ph.D., a postdoctoral fellow in the Romanski lab and co-author of this study.
Babies' expectations may help brain development
Monday, July 20, 2015
Infants can use their expectations about the world to rapidly shape their developing brains, researchers have found.
A series of experiments with infants 5 to 7 months old has shown that portions of babies' brains responsible for visual processing respond not just to the presence of visual stimuli, but also to the mere expectation of visual stimuli, according to researchers from the University of Rochester and the University of South Carolina.
That type of complex neural processing was once thought to happen only in adults—not infants—whose brains are still developing important neural connections.
We show that in situations of learning and situations of expectations, babies are in fact able to really quickly use their experience to shift the ways different areas of their brain respond to the environment, said Lauren Emberson, who conducted the study at the University of Rochester's Baby Lab while a research associate with Richard Aslin in the department of brain and cognitive sciences.
For more information, visit the University of Rochester Newscenter.Read More: Babies' expectations may help brain development
Researcher Wins Auditory Neuroscience Award
Tuesday, July 7, 2015
Laurel Carney, a professor of Biomedical Engineering, has been recognized for her work by the premier scientific organization in the field of acoustics. The Acoustical Society of America has awarded Carney the William and Christine Hartmann Prize in Auditory Neuroscience.
It's truly a great honor to receive an award created by Bill and Christine Hartmann, two of my role models, said Carney.
I welcome the challenge to emulate their life of discovery, presentation, publication, service, and education throughout the world.
William and Christine Hartmann established the award with a donation to recognize and honor
research that links auditory physiology with auditory perception or behavior in humans or other animals. William Hartmann is a physicist, psychoacoustician, and former president of the Acoustical Society of America. His contributions to the field involved pitch perception, signal detection, modulation detection, and the localization of sound.
In her research lab, Carney is working to better understand how the brain translates sounds into patterns of electrical impulses. By studying physiology, human hearing, and computer models, Carney hopes to learn how the brain distinguishes sounds in noisy environments and why even a small degree of hearing loss can lead to major problems. Her ultimate goal is to develop effective strategies to help people who have experienced hearing loss.
Carney earned her M.S. and Ph.D. degrees in electrical engineering at the University of Wisconsin-Madison. She was an associate professor of biomedical engineering at Boston University and professor of biomedical engineering at Syracuse University before joining the faculty at the University of Rochester in 2007, where she serves as professor in three departments—biomedical engineering, neurobiology and anatomy, and electrical and computer engineering.
For additional information, visit the Rochester Newsroom.
Flaum Eye Institute Scientist Gets Funding to Study Vision Loss in Batten Disease
Thursday, July 2, 2015
Ruchira Singh, Ph.D.
University of Rochester Medical Center scientist Ruchira Singh, Ph.D., received a grant from the
Knights Templar Eye Foundation to investigate how neurodegenerative diseases,
such as juvenile Batten disease, cause blindness.
Singh, assistant professor of Ophthalmology and Biomedical Genetics, will use the $60,000
grant to create a human model of Batten disease (CNL3) using patient’s own cells. The project may lead to better understand the disease mechanisms, aiding in the
development of drug therapies to preserve vision in affected patients.
For the complete article, visit the URMC newsroom.Read More: Flaum Eye Institute Scientist Gets Funding to Study Vision Loss in Batten Disease
Mink Receives First Ever Tourette’s Association of America Award
Wednesday, July 1, 2015
Dr. Jonathan Mink
Jonathan Mink, M.D., Ph.D., chief of Child Neurology at Golisano Children’s Hospital, is the first recipient of the Tourette Association of America’s Oliver Sacks Award for Excellence. The award, named for the famous British neurologist, was to be presented at the First World Congress on Tourette Syndrome and Tic Disorders, but due to a scheduling conflict, representatives from TAA instead traveled to Rochester to present him with the award in a surprise ceremony.
The award is in recognition of his many years of leadership, mentorship, research, and care on behalf of all people touched by Tourette syndrome and tic disorders around the world.
$4M NIH Award Expands Joint Training of Deaf Scholars in Rochester
Friday, June 26, 2015
The University of Rochester School of Medicine and Dentistry has received nearly $4 million for a program that would serve as a national model to educate post-doctoral students who are deaf or hard-of-hearing.
The grant makes it possible to expand and strengthen an ongoing, unique relationship between the UR, Rochester Institute of Technology and RIT’s National Technical Institute for the Deaf to prepare deaf and hard-of-hearing scholars for careers in the biomedical and behavioral sciences. Two years ago the local institutions partnered to build a similar program for graduate students, facilitating the transition from master’s degree programs offered at RIT to Ph.D. programs at UR. Read More: $4M NIH Award Expands Joint Training of Deaf Scholars in Rochester
B&B Department Mourns the Loss of Rose Burgholzer
Wednesday, June 24, 2015
It is with much sadness that we inform everyone of the passing of Rose Burgholzer, after a long and courageous battle with cancer. Rose worked at the University for 40 years, almost half of that as an administrator in our department. She was a dear friend and colleague and will be greatly missed. Many former students remember Rose fondly and have communicated with her during her illness, and she graciously received a steady stream of visiting faculty and staff in her home these past few years.
A Funeral Mass was held Wednesday, June 17, at St. Kateri at St. Margaret Mary Church in Rochester, with entombment at Holy Sepulchre Cemetery. Memorials may be directed to a charity of your choice. View her obituary and a slideshow from Rose's family.
Duje Tadin explains how understanding GPS can help you hit a curveball
Monday, June 22, 2015
Our brains track moving objects by applying one of the algorithms your phone's GPS uses, according to researchers at the University of Rochester.
This same algorithm also explains why we are fooled by several motion-related optical illusions, including the sudden
break of baseball's
Like GPS, our visual ability, although quite impressive, has many limitations, said the study's coauthor, Duje Tadin, associate professor of brain and
cognitive sciences at the University of Rochester.
The new open-access study published in PNAS shows that our brains apply an algorithm, known as a Kalman filter, when tracking
an object's position. This algorithm helps the brain process less than perfect visual signals, such as when objects move to the periphery of our visual field where acuity is low.Read More: Duje Tadin explains how understanding GPS can help you hit a curveball
Upcoming NGP PhD Defenses
Monday, June 22, 2015
Two NGP students are presenting their defense seminars next week.
Wei Sun defends on Monday June 29th and Adam Pallus defends on July 1st
To read their abstracts, visit the Defense Seminars site.Read More: Upcoming NGP PhD Defenses
Congratulations to Brianna Sleezer on becoming the first intern matched from URBEST!
Wednesday, June 17, 2015
Brianna Sleezer, NSC PhD student
Brianna Sleezer, a neuroscience PhD graduate student in the Hayden Lab, is URBEST's
(Broadening Experiences in Scientific Training)
first intern that has been matched with a host: The Children's Environmental Health Network. Brie made things happen by connecting with Nsedu Obot Witherspoon,
the Executive Director for CEHN, at a URBEST Career Story. She'll be starting her three-month internship at the beginning of September.
URBEST is a five-year, NIH-funded program to help health science and biomedical PhD graduate students and postdoctoral appointees to explore and better prepare
themselves for diverse career paths. The program combines educational activities to highlight research-related careers and to instruct in leadership and professionalism.
The URBEST program also provides opportunities to a subgroup of trainees for short-term (hours per week) or long-term (full time for up to three month) internships
as a capstone experience. Internship candidates are selected based on their research productivity, engagement in URBEST activities and PI approval.
Kerry O'Banion presents at the CTSI Workshop - Patent Infringement: COX Fighting
Sunday, June 14, 2015
Kerry O'Banion, interim chair of the Department of Neurobiology and Anatomy, and University President Emeritus Thomas Jackson will present Read More: Kerry O'Banion presents at the CTSI Workshop - Patent Infringement: COX Fighting
Patent Infringement: COX Fighting, from noon to 1 p.m. Wednesday, June 17, in Helen Wood Hall Auditorium. The event is part of the CTSI workshop series,
Good Advice: Case Studies in Clinical Research, Regulation, and the Law.
Foxe Appointed to Head Neuromedicine Research at URMC
Tuesday, June 9, 2015
John J. Foxe, Ph.D., a nationally-regarded scientist in the field of neurobiology, has been named the research director of the DelMonte Neuromedicine Institute (DNI) and the Kilian J. and Caroline F. Schmitt Chair of the Department of Neurobiology and Anatomy at the University of Rochester School of Medicine and Dentistry.
The University of Rochester has long been home to some of the nation’s most innovative and groundbreaking research in the field of neuroscience and neuromedicine, said Joel Seligman, president of the University of Rochester.
John’s appointment signals our determination to make this field a centerpiece of our progress as a University and Medical Center.
Read More: Foxe Appointed to Head Neuromedicine Research at URMC
I am honored to be taking the helm of the DNI at this incredibly exciting time in modern neuroscience research, said Foxe.
The University of Rochester is already world-renowned for its superb work in this field and we now have the opportunity to build an even stronger presence. Tens of millions of Americans suffer from a major mental illness each year, be it depression or anxiety, a major psychotic disorder, or Alzheimer’s disease, stroke, or addiction. And the list goes on. The National Institutes of Health estimates that only about half of these people ever receive treatment. We can and we must do better. It is only through research that we can develop new effective treatments and I am committed to placing the DNI and the University of Rochester at the very forefront of these efforts.
$10 Million Grant Funds Center to Study OCD at UR School of Medicine and Dentistry
Thursday, June 4, 2015
Suzanne Haber leads a research team to investigate OCD. She says the disease is characterized by intrusive,
ruminating thoughts (obsessions), and impulses to carry out repetitive behaviors (compulsions), despite the awareness by most patients that these behaviors don't make sense.
The goal of a new $10 million grant awarded to the scientists is to improve our understanding of the brain networks that play a central role in
obsessive-compulsive disorder (OCD).
Together with leading mental health researchers at four other institutions in the U.S., they will pinpoint specific abnormalities within the brain circuits that
are associated with the disease and use this information to guide new treatment options for the three million-plus Americans who live with the disorder.
The five-year grant from the National Institute of Mental Health (NIMH) establishes a new
Silvio O. Conte Center for Basic and Translational Mental Health Research at the University of Rochester. Conte Centers are designed to bring scientists with diverse
but complimentary backgrounds together to improve the diagnosis and treatment of mental health disorders.
Read More: $10 Million Grant Funds Center to Study OCD at UR School of Medicine and Dentistry
13 Things to Know About Biomedical Research at UR
Friday, May 29, 2015
The Democrat and Chronicle was one of 12 Gannett newspapers that partnered with a USA Today investigation, Biolabs in Your Backyard, about the concerns and dangers that can accompany biomedical research.
The investigation focused on more than 200 high-containment biomedical labs around the nation that are equipped to handle select agents and other dangerous research.
Research involving select agents is considered by the federal government to be the most worrisome biomedical lab work because of potential health risks and security concerns, especially since some of these agents and toxins can be used in biological warfare.
The University of Rochester has one high-containment lab at its medical center that in recent years has worked with Francisella tularensis, which is a Tier I select agent, the highest level of concern.
Read More: 13 Things to Know About Biomedical Research at UR
Pharmacology Speakers and Students Win Poster Awards at UNYPS
Tuesday, May 19, 2015
Congratulations to the following Graduate Students and Invited Student Speakers for winning poster awards at the 4th Annual Upstate New York Pharmacology Society (UNYPS) meeting G-Protein Coupled Receptor Signaling Systems in Health and Diseasewhich was held at the University of Rochester on May 19th, 2015. Graduate student winners were Hannah Stoveken,
working in the lab of Dr. Gregory G. Tall Isaac Fisher, working in the lab of Dr. Alan V. Smrcka Alex Hajduczok, working in the lab of Dr. Gregory G. Tall and Rafael Gil de Rubio, working in the lab of Dr. Alan V. SmrckaInvited student speaker winners were Walter Knight, Bharti Patel, graduate student in the lab of Dr. Gregory G. Tall and Jesi Lee Anne To, graduate student in the lab of Dr. Alan V. Smrcka
Ben Crane Awarded Nicholas Torok Vestibular Award by the American Neurotology Society
Monday, May 11, 2015
Otolaryngology associate professor, Benjamin Crane, MD, PhD, was awarded the Nicholas Torok Vestibular Award by the American Neurotology Society at the 50th Annual meeting in Boston on April 25th. The title of his presentation was
An automated vestibular rehabilitation method for unilateral vestibular hypofunction.
The $1500 award is offered by the Society for the best lecture on an innovative observation, experience or technique in the field of Vestibular Basic Science, i.e., physiology, pathology or subjects serving clinical progress.
Understanding the Enemy Within that Causes Brain Damage after Cardiac Arrest
Thursday, May 7, 2015
A new $1.7 million grant will bring together a team of researchers to study – an ultimately thwart – the chain reaction that occurs in the body after cardiac arrest that can ultimately lead to brain damage and death.
“While the biological sequence of events is triggered by cardiac arrest, the death and disability associated with this event is the result of a broader systemic injury caused the initial loss of blood flow and subsequent tissue inflammation once blood circulation is restored,” said University of Rochester Medical Center neurologist Marc Halterman, M.D., Ph.D., the principal investigator of the study. Read More: Understanding the Enemy Within that Causes Brain Damage after Cardiac Arrest
In fact, it is the cumulative effect of this systemic injury on the brain, and not the heart – that ultimately leads to mortality in the disorder.
2015 Awards Announced
Wednesday, May 6, 2015
The 2015 Vincent duVignaeud Award for excellence in basic research will be awarded at this year’s commencement to Dr. Steven Baker who completed his Ph.D. in Luis Martinez-Sobrido’s lab.
The 2015 Wallace O. Fenn Award for excellence in basic research will be awarded at this year’s commencement to Dr. Julie Sahler who completed her Ph.D. in Richard Phipps’ lab.
Award Recipients for the Melville A. Hare Award for Excellence in Research have been awarded to Dr. Denise Skrombolas who completed her Ph.D. in the lab of John Frelinger and Dr. Benson Cheng who completed his Ph.D. in Luis Martinez-Sobrido’s lab.
The Melville A. Hare Award for Excellence in Teaching has been awarded to Jennifer Colquhoun. Jennifer is in Paul Dunman’s laboratory.
A Departmental Peer Mentoring Award was established this year. The recipient of the 2015 award is Lisbeth Boule. Lisbeth is in Paige Lawrence’s laboratory.
Professors Dalecki and Hocking Research Wins Best Paper Award at SPIE-DSS
Wednesday, May 6, 2015
The latest research by Professor Diane Dalecki (BME, RCBU) and Professor Denise C. Hocking (Pharmacology & Physiology, BME, RCBU) was recognized with the Best Paper Award at the Micro- and Nanotechnology Sensors, Systems, and Applications Conference of the SPIE Defense + Security Symposium held recently in Baltimore, Maryland. Their invited paper titled “Guiding Tissue Regeneration with Ultrasound In Vitro and In Vivo” detailed three biomedical ultrasound technologies under development in their laboratories to stimulate tissue formation and regeneration. Co-authors of the paper included Sally Child, Carol Raeman, and BME graduate students Eric Comeau and Laura Hobbs. One technology under development employs forces within an ultrasound standing wave field to provide a noninvasive approach to spatially pattern endothelial cells and thereby guide the development of complex microvessel networks. A second technology uses ultrasound to site-specifically control the microstructure of collagen fibers within engineered hydrogels to direct cell function. The third line of research focuses on developing ultrasound as a therapeutic approach to enhance tissue regeneration in chronic wounds. These ultrasound technologies offer new solutions to key challenges currently facing the fields of tissue engineering, biomaterials fabrication, and regenerative medicine.
The SPIE DSS 2015 Defense + Security Symposium consisted of 32 separate conferences spanning 5 days with over 1200 total presentations. Conferences focused on a wide range of topics of interest to defense and security, including imaging, sensing, photonics, materials, and biomedical applications. The Symposium is the leading meeting for scientists, researchers and engineers from industry, military, government agencies, and academia throughout the world. The Micro- and Nanotechnology Sensors, Systems, and Applications Conference is one of the two largest conferences within the entire Defense + Security Symposium, and Professors Hocking’s and Dalecki’s presentation was one of over 100 invited presentations in the conference.
Lower Air Pollution, Higher Birth Weight
Tuesday, May 5, 2015
A team of researchers led by Associate Professor, Dr. David Rich (Public Health Sciences & Environmental Medicine) studied birth weights before, during and after the Beijing Olympics, during which widespread pollution reduction efforts were instated. They found infants born shortly after the Olympics had significantly higher birth weights than infants born in other years. The researchers compiled information from 83,672 term births (37 to 42 weeks gestational age at birth) to mothers in four urban districts in Beijing. They compared birth weights for mothers whose eighth month of pregnancy occurred during the 2008 Olympics/Paralympics with those whose eighth month of pregnancy occurred at the same time of year in the years before (2007) and after (2009) the games when pollution levels were at their normally higher levels. They found that the babies born in 2008 were on average 23 grams larger than those in 2007 and 2009.Read More: Lower Air Pollution, Higher Birth Weight
Rianne Stowell Receives Honorable Mention for NSF Research Fellowship
Friday, May 1, 2015
Rianne Stowell, Ph.D. candidate
Four University of Rochester graduate students and seven alumni have been named recipients of the National Science Foundation Graduate Research Fellowships. Additionally, five current students and 11 recent alumni were given honorable mentions by the NSF.
The fellowship, which is part of a federally sponsored program, provides up to three years of graduate study support for students pursing doctoral or research-based master’s degrees. Since the program’s inception in 1952, NSF has provided fellowships to individuals selected early in their graduate careers based on their demonstrated potential for significant achievements in science and engineering. Of the more than 16,500 applicants this year, only 2,000 were awarded fellowships. The fellowship includes a three-year annual stipend of $34,000, a $12,000 educational allowance to the institution, and international research and professional development opportunities for recipients.
Congratulations Rianne on the honorable mention!!
For the complete list of recipients, visit the story at the UR Newsroom.Read More: Rianne Stowell Receives Honorable Mention for NSF Research Fellowship
Rochester team receives National Eye Institute grant for restoring vision through retinal regeneration
Friday, May 1, 2015
David Williams, the William G. Allyn Professor of Medical Optics, Dean for research and Director of the Center for Visual Science
A team of researchers at the University of Rochester is designing an optical system to image responses to light of large numbers of individual cells in the retina, with the objective of
accelerating the development of the next generation of cures for blindness. The Rochester team and their partners will receive $3.8 million from the National Eye Institute over the next five years.
The new instrumentation we are developing builds on technology we had developed previously to improve vision through laser refractive surgery and contact lenses, as well as to
diagnose retinal disease, said Rochester's principal investigator David Williams.
This is the first time we have designed instrumentation specifically to develop and test therapies
to restore vision in the blind.
The National Eye Institute (NEI), part of the National Institutes of Health, announced the awards as part of its Audacious Goals
Initiative to tackle the most devastating and difficult to treat eye diseases. The central goal is to restore vision by regenerating neurons and neural connections in the eye and visual system.
The initiative places special emphasis on cells of the retina, including the light-sensitive rod and cone photoreceptors, and the retinal ganglion cells, which connect photoreceptors to
the brain via the optic nerve.
For the entire article, visit the University
Newscenter.Read More: Rochester team receives National Eye Institute grant for restoring vision through retinal regeneration
URMC Start-up Takes Aim at Memory and Cognitive Problems
Thursday, April 30, 2015
Medications are available to treat many of the symptoms of neurodegenerative diseases like multiple sclerosis and Parkinson’s disease, but there is no drug or other therapy that improves the memory and cognitive problems that often plague patients. A new start-up company, built around research conducted at the University of Rochester School of Medicine and Dentistry, hopes to change that.
Camber NeuroTherapeutics Inc., founded based on discoveries made in the laboratories of Harris "Handy" A. Gelbard, M.D., Ph.D. and Stephen Dewhurst, Ph.D., plans to attack the cognitive component of neurodegenerative diseases using a completely new approach: stopping the inflammation in the brain, so-called neuroinflammation, that impairs the function of nerve cells and the vast networks they create. These neural networks allow us to store and recall memories, plan and prioritize, focus on particular tasks, and process sensory information.Read More: URMC Start-up Takes Aim at Memory and Cognitive Problems
Dr. David Yule invited to join Editorial Board of Gastroenterology
Wednesday, April 29, 2015
David I. Yule, Ph.D., Professor of Pharmacology and Physiology; of Medicine, Gastroenterology/Hepatology; and in the Center for Oral Biology has been invited to join the Editorial Board of Gastroenterology. Gastroenterology is the preeminent journal in the field of gastrointestinal disease. Gastroenterology is ranked 1st of 74 journals in the Gastroenterology and Hepatology category on the 2013 Journal Citation Reports, and has an Impact Factor of 13.926. As the official journal of the American Gastroenterological Association, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology. Regular features include articles by leading authorities and reports on the latest treatments for diseases. Original research is organized by clinical and basic-translational content, as well as by alimentary tract, liver, pancreas, and biliary content.
Melinda Vander Horst presents at NCUR
Wednesday, April 29, 2015
Melinda Vander Horst (BME Class 2015) presented her recent research at the 29th Annual National Undergraduate Research Conference (NCUR) held at Eastern Washington University in April. NCUR is an interdisciplinary conference where undergraduate students representing universities from around the world present their research and creative works. Melinda presented her poster, titled
Development of a dual transducer system for ultrasound standing wave field-induced particle banding, with co-authors Eric Comeau (BME graduate student), Denise C. Hocking (Pharmacology & Physiology), and Diane Dalecki (BME). Melinda is a Xerox Undergraduate Research Fellow working with Professors Dalecki and Hocking on new ultrasound technologies for tissue engineering.
Anolik Elected to American Society for Clinical Investigation
Monday, April 27, 2015
Dr. Jennifer Anolik with
MSTP Director, Dr. Kerry O'Banion
Jennifer H. Anolik, M.D., Ph.D., associate professor of Medicine in the Division of Allergy/Immunology and Rheumatology, was named a member of the American Society for Clinical Investigation, one of the nation’s oldest and most respected medical honor societies. Anolik, who runs URMC’s Lupus Clinic and Program, was nominated for her work conducting translational and basic science research on lupus and rheumatoid arthritis. She joins 18 other Medical Center faculty members who have been inducted into the Society in the past. Anolik is a former URMC MSTP (M.D., '96) and Biochemistry (Ph.D., '94) student. During her time in the program, she conducted research with Robert Bambara, Ph.D. and Russell Hilf, Ph.D..
Anolik’s research focuses on the role of B cells in systemic autoimmune disease through synergistic and innovative approaches in translational immunology and animal models. It has fundamentally contributed to the understanding of how and why B cell targeted therapies can be efficacious in subsets of lupus and rheumatoid arthritis patients and established these therapies as a major advance in the field of immunologic disease. Her work has broad implications for other autoimmune diseases such as vasculitis and diabetes, as well immunologic diseases like malignancy and immune deficiency.
Under Anolik’s leadership, URMC was one of 11 research groups across the country recently chosen by the National Institutes of Health to join the NIH Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, a partnership between the NIH, biopharmaceutical companies, advocacy organizations and academic scientists to more rapidly identify promising drug targets and develop new treatments for patients with these conditions. Anolik’s team was selected for this highly competitive award based on the novelty of their translational research proposal coupled with the unique collaboration between Orthopaedics and Rheumatology at URMC.
Read the entire press release.
Does Artificial Food Coloring Contribute to ADHD in Children?
Monday, April 27, 2015
Kraft Macaroni & Cheese -that favorite food of kids, packaged in the nostalgic blue box—will soon be free of yellow dye. Kraft announced Monday that it will remove artificial food coloring, notably Yellow No. 5 and Yellow No. 6 dyes, from its iconic product by January 2016. Instead, the pasta will maintain its bright yellow color by using natural ingredients: paprika, turmeric and annatto (the latter of which is derived from achiote tree seeds).
The company said it decided to pull the dyes in response to growing consumer pressure for more natural foods. But claims that the dyes may be linked to attention-deficit hyperactivity disorder (ADHD) in children have also risen recently, as they did years ago, putting food dyes under sharp focus once again. On its Web site Kraft says synthetic colors are not harmful, and that their motivation to remove them is because consumers want more foods with no artificial colors.
Bernard Weiss, professor emeritus of the Department of Environmental Medicine at the University of Rochester Medical Center who has researched this issue for decades, says he is frustrated that the FDA has not acted on the research showing the connection between artificial dyes and hyperactivity. Read More: Does Artificial Food Coloring Contribute to ADHD in Children?
All the evidence we have has showed that it has some capacity to harm, he says.
In Europe that's enough to get it banned because a manufacturer has to show lack of toxic effects. In this country it's up to the government to find out whether or not there are harmful effects. Weiss supports banning artificial colors until companies have evidence that they cause no harm. Like most other scientists in this field, he thinks more research, particularly investigating dyes' effects on the developing brain, is imperative.
NGP Graduate Student, Grayson Sipe, Wins Award for Excellence in Teaching
Monday, April 27, 2015
Grayson Sipe, Ph.D. candidate and Margaret H. Kearney, PhD, RN, FAAN, Professor and Vice Provost & University Dean of Graduate Studies.
Grayson Sipe, a Neuroscience Graduate Program student in Dr. Ania Majewska's lab, studying the roles of microglia during synaptic plasticity, has been named a winner of the 2015 Edward Peck Curtis Award for Excellence for Graduate Student Teaching.
Only a handful of these are awarded each year, and all this year's nominees were extremely well-qualified.
Maquat and Kurosaki Awarded Fellowship
Friday, April 24, 2015
Lynne Maquat, the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, and Research Assistant Professor, Tatsuaki Kurosaki, Ph.D. have been awarded FRAXA Postdoctoral Fellowship for their application entitled,
Re-purposing clinically approved drugs to dampen hyperactive nonsense-mediated mRNA decay in fragile X syndrome.
The FRAXA Research Foundation was extremely impressed with their proposed research, and
delighted to support this exciting work. Funding of 45,000 has been authorized for the period from May 1, 2015 to April 30, 2016.
Congrats to both Lynne and Tatsuaki!
Gloria Culver, Biochemistry Program Graduate, Appointed Dean of the School of Arts & Sciences
Wednesday, April 22, 2015
Gloria Culver, former Biochemistry graduate student in the Phizicky Lab, has been appointed dean of the School of Arts & Sciences, effective immediately. Culver is currently a professor of Biology and Biochemistry & Biophysics. Peter Lennie, the Robert L. and Mary L. Sproull Dean of the Faculty of Arts, Sciences & Engineering, made the announcement following a yearlong national search. Culver has been serving as interim dean since July 1, 2014.Read More: Gloria Culver, Biochemistry Program Graduate, Appointed Dean of the School of Arts & Sciences
Harold Smith Awarded Drug Development Pilot Award
Tuesday, April 14, 2015
Biochemistry & Biophysics Professor, Harold Smith, PhD has been awarded a Drug Development Pilot Award for his project,
Development of an Assay for High Throughput Screening for Antagonists of the Ebola VP40 Protein Function. The project was externally reviewed by leading drug development researchers and received a meritorious score. To learn about Dr. Smith's research please visit the Smith lab site.
Celebrating 50 Years at URMC and Saying Goodbye: Victor Laties
Friday, April 10, 2015
Dr. Victor Laties, Professor Emeritus
In 1965, a young Victor Laties left Johns Hopkins for the University of Rochester and never looked back. In 2015, Vic celebrated his 50th year at the University of Rochester Medical Center-a feat not surpassed by many. Primarily in the department of Environmental Medicine, Vic has touched many lives over the years with his great work ethic, caring attitude, his love of toxicology, and his fantastic photos that have graced the Environmental Medicine, Environmental Health Sciences Center (EHSC), and Toxicology websites over the past 50 years.
The first director of the toxicology training grant, that is now in his 37th year, Vic has been integral to it's success and has created many memories and passed down a wealth of knowledge to hundreds of students. Beginning in the departments of Biophysics, Psychology, and Pharmacology Vic has also made many a friend and has been a valued colleague to his peers. Vic has remained on the editorial board for the Journal of the Experimental Analysis of Behavior since 1962 (and the webmaster for the JEAB/JABA site), and has served as editor for several other experimental therapeutics and pharmacological journals throughout the years.
Vic won the Distinguished Service to Behavior Analysis Award from the Society for the Advancement of Behavior Analysis (SABA) in 1995 and 2003-the only person to win this award twice. He was a major figure in the development of both behavioral pharmacology and behavioral toxicology. His work with the Society for the Experimental Analysis of Behavior (SEAB) journals has been essential to their development and their sustained excellence over the last forty years. To date he has published well over 100 journal articles, book chapters and various other publications.
Vic's love of toxicology and the department is surpassed only by his love for his wife and family as he officially retires today and moves to Maryland to be closer to them and enjoy the nice weather. The department and all of his colleagues wish to express their heartfelt gratitude for the many years of service and contributions that he has given. He is truly one of a kind and will be missed.
To read more about Vic's many accolades please see the Association for Behavior Analysis International article and view his CV.
Vic and the Environmental Medicine, Toxicology and EHSC Staff
Lynne Maquat to Present Annual Hoffman Lecture
Thursday, April 9, 2015
Lynne Maquat, the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, will present the 17th annual Marvin J. Hoffman Lecture, "RNA and the New Genetics: From Bench to Therapeutics." The lecture begins at noon Friday, April 17, in the Class of '62 Auditorium (G-9425), Medical Center. RSVP to 273-5937 or email@example.com.
Celebrating Brain Awareness Week!
Wednesday, April 8, 2015
NGP student (with the support of PONs and SfN Rochester Chapter) organized the annual Brain Awareness Week and provided activities for grades K-3 at area schools.
Over the span of 2 weeks, from March 16-27, NGP students visited 19 classrooms at three different schools (Colebrook School in Irondequoit, Indian Landing in Penfield and
West Ridge in Greece), grades K-4 working with over 350 kids!
They brought activities to the kids that focused on signal transduction, memory and perception. There was a team of 35 volunteers, including BCS and neuroscience undergrad
and grad students that traveled to the schools. 6 NGP students were among the volunteers (Julianne Feola, Christy Cloninger, Jenn Stripay, Becky Lowery, Ryan Dawes and
Susanne Pallo) participating in the planning and organization of the activities, school visits and training sessions.
Visit the Brain Awareness Week
Facebook page for more information.Read More: Celebrating Brain Awareness Week!
Marissa Sobolewski Wins Butcher New Investigator Award and 2nd Place Postdoctoral Fellow Poster Award at SOT
Friday, April 3, 2015
Postdoctoral Fellow in the Cory-Slechta lab, Marissa Sobolewski, PhD finished second in the Neurotoxicology SS Toshio Narashashi Postdoctoral Fellow Poster Award at the Society of Toxicology (SOT) annual meeting in San Diego, CA. last week.
Marissa also recently won the Richard Butcher New Investigator Award from the Neurobehavioral teratology society. Her research focus is Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity. Congrats!
UR Toxicology Graduate Students Make Strong Showing at 2015 SOT Meeting
Friday, April 3, 2015
Dr. Alison Elder and Elissa Wong
UR Toxicology graduate students made a strong showing at the Society of Toxicology (SOT) annual meeting in San Diego, CA. last week. 3rd year graduate student, Elissa Wong (Majewska Lab) and 5th year graduate student, Sage Begolly (O'Banion/Olschowka Labs) both won travel awards to attend and present their posters.
Elissa Wong and Dr. Alison Elder also attended the event, hosting the UR recruitment table at the Society of Toxicology (SOT) Committee on Diversity Initiatives (CDI) session. Congrats to all!
View all of the photos from the SOT meeting.
Former IGPN student Laurie Robak, M.D., Ph.D. Receives Fellowship Award
Monday, March 30, 2015
Laurie Robak, MD, PhD
Laurie Robak, MD, PhD, who graduated from the IGPN program in 2009, is a clinical fellow in the Laboratory for Integrative Functional Genomics, and is also
currently completing her dual residency training in pediatrics and medical genetics. July 1st of this year, Laurie will be a postdoctoral research associate/clinical
instructor in the laboratory of Dr. Joshua Shulman at Baylor Medical College, researching the genetics
of Parkinson’s disease. Laurie recently received the Pfizer/ACMG Foundation Translational Genomic Fellowship Award.
Robert Dirksen to Head Department of Pharmacology and Physiology
Monday, March 30, 2015
Robert T. Dirksen, Ph.D. will serve as chair of the Department of Pharmacology and Physiology at the University of Rochester School of Medicine and Dentistry effective July 1, 2015, pending approval by the University Board of Trustees. Dirksen, who has conducted research and taught medical and graduate students at the University since 1998, is known for his superb track record of federal funding, his collaborative nature and his ability to inspire and engage trainees and colleagues alike.
“Bob recognizes the central role that Pharmacology and Physiology plays in much of the research that is conducted at the Medical Center and has a very clear and compelling vision for the future of the department,” said Mark B. Taubman, M.D., Dean of the School of Medicine and Dentistry and CEO of the University of Rochester Medical Center. “He is the perfect person to lead a group that bridges multiple scientific fields and clinical areas and we’re very excited for him to take the reins.”Read More: Robert Dirksen to Head Department of Pharmacology and Physiology
Blocking Cellular Quality Control Mechanism Gives Cancer Chemotherapy a Boost
Friday, March 27, 2015
A University of Rochester team found a way to make chemotherapy more effective, by stopping a cellular quality-control mechanism, according to a study published today in Nature Communications.
The mechanism is known as NMD (nonsense-mediated mRNA decay), and scientists found that exposing breast cancer cells to a molecule that inhibits NMD prior to treatment with doxorubicin, a drug used to treat leukemia, breast, bone, lung and other cancers, hastens cell death.
The research team, led by Lynne E. Maquat, Ph.D., director of the Center for RNA Biology at the University of Rochester, acknowledges that the work is in the early stages and a long way from being applied in humans. But, they believe their data provide insights that could lead to new treatment strategies for cancer patients in the future. Read More: Blocking Cellular Quality Control Mechanism Gives Cancer Chemotherapy a Boost
Lynne Maquat Receives 2015 Gairdner International Award
Thursday, March 26, 2015
Lynne E. Maquat, Ph.D. received the 2015 Gairdner International Award for the discovery and mechanistic studies of nonsense-mediated mRNA decay, a cellular quality control mechanism that derails the production of unwanted proteins in the body that can disrupt normal processes and initiate disease. She is one of five scientists honored with the award, which is given every year to recognize the achievement of medical researchers whose work contributes significantly to improving the quality of human life.
The J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics at the University of Rochester Medical Center, Maquat is known around the world for her work on nonsense-mediated mRNA decay, which is critically important in both normal and disease states. She is considered the uncontested pioneer on the subject and in 2011 was elected to the National Academy of Sciences for her exceptional research, which has been published in more than 130 peer-reviewed scientific articles.
Maquat is the first scientist from upstate New York to receive the Gairdner International Award, which is recognized for its rigorous peer-led selection process. A panel of active Canadian scientists reviews all nominations and passes their recommendations to a board of two dozen senior scientists from across Canada, the United States, Europe, Australia and Japan. After in-depth study and review, board members cast votes for the nominees whose achievements rise above all others in their field. According to the Gairdner Foundation, of the 313 winners to date, 82 have gone on to receive a Nobel Prize in Physiology or Medicine, a testament to the quality of the awardees.
The award was also highlighted in the Opinion pages of Saturday’s Democrat and Chronicle in the Read More: Lynne Maquat Receives 2015 Gairdner International Award
Thumbs up, thumbs down section:
Thumbs up: For Dr. Lynne Maquat, who is one of five biomedical researchers from around the world to win this year's Gairdner International Award. The University of Rochester Medical Center scientist has joined a prestigious group. Since 1959, more than a quarter of the Gairdner International winners have gone on to win a Nobel Prize, too.
B&B Graduate Students 'Bootleg' Their Way to the Top
Friday, March 20, 2015
The Biochemistry and Biophysics department is pleased to announce that a number of the department's graduate students have undertaken a very creative project. Specifically, six of our graduate students have been writing, producing, and voice acting in a serial podcast about bootleggers smuggling rum across Lake Ontario in 1921.
You can access the first three episodes on iTunes, or you can find them on their Pocket Radio Theater Facebook page. While contingent on their individual research workloads, their plan is to release more episodes on a monthly basis for a total of around 20.
Check out the creative endeavors of your departmental colleagues!
Stoveken, Lerman Win Awards at Falling Walls Competition
Tuesday, March 17, 2015
Congratulations to Hannah Stoveken, Graduate student in the lab of Gregory G. Tall Associate Professor of Pharmacology and Physiology, who took second place in the University's First Falling Walls Competition and $300.
Honorable mention went to Yelena Lerman, a graduate student working with Minsoo Kim, Associate Professor of Microbiology and Immunology. Full article in Research Connections at the University of Rochester can be found here
WATCH: NY Med Schools Ask Legislature to Invest in Retention of Top Biomedical Researchers
Monday, March 16, 2015
Medical Schools in New York State are asking the legislature to include $50 million for faculty development in the state budget. University leadership calls the NYSTAR Faculty Development Program an investment needed to grow programs that will attract high-profile entrepreneurial biomedical researchers.Read More: WATCH: NY Med Schools Ask Legislature to Invest in Retention of Top Biomedical Researchers
Microbiologist Barbara Iglewski Named to National Women’s Hall of Fame
Thursday, March 12, 2015
Barbara H. Iglewski, Ph.D., professor emeritus in the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry will be inducted into the National Women's Hall of Fame later this year, an incredible honor that puts her aside women’s rights activist Susan B. Anthony, former first lady Betty Ford, and founder of the Susan G. Komen Breast Cancer Foundation Nancy Brinker.
Read More: Microbiologist Barbara Iglewski Named to National Women’s Hall of Fame
VasoMark advances to the next phase!
Tuesday, March 10, 2015
The VasoMark Team
A group of students from Neuroscience Graduate Program and Neurosurgery Residency Program have teamed up to compete in the
National Institutes of Health
Neuro Startup Challenge.
This new effort offers pre- and post-doctoral students from biomedical, legal, and business backgrounds the opportunity to compete for licenses
to patented technologies from the NIH portfolio.
The teams model a business around the intellectual property, and seek startup funding from partnering angel investor and
venture capitalist firms in order to bring the proposed technology to the biomedical marketplace. The NGP and Neurosurgery team,
named VasoMark, selected two patents for the development of a minimally invasive diagnostic for the detection of primary and
recurrent malignant brain tumors. VasoMark successfully completed Phase I of the competition, where they developed a two-minute
elevator pitch and executive summary describing their intended entrepreneurial use of the selected technology. They are
currently developing a business plan and live investor pitch describing their business model, intended market, and future areas
of expansion for their selected patents.
Department Announces Fred Sherman Student Award
Friday, March 6, 2015
The Department of Biochemistry & Biophysics are very pleased to announce a new student award within the Biochemistry and Molecular Biology program, to be given at our annual Awards Ceremony in May.
The Fred Sherman Award will honor the memory of our former colleague, and will annually recognize a student in the BMB program who exemplifies the imagination, the excellence in the pursuit of scientific knowledge, and the commitment to the scientific community that were characteristic of Fred Sherman.
This award will compliment the William F. Neuman Award, given annually to a BSCB student to recognize academic, scientific and personal qualities which exemplify the imagination, enthusiasm and excellence in the pursuit of scientific knowledge which were characteristic of the life of Dr. William F. Neuman.
Anna Bird Awarded Pilot Project Grant
Thursday, March 5, 2015
Anna Bird, an IMV graduate student in the Anolik lab has been awarded pilot project grant through the Pilot Studies Program of the CTSI. Anna’s application entitled, “Neutrophils as a driver of inflammation in lupus bone marrow” was felt to be highly meritorious and received a priority score enabling her proposal to be funded.
Mini-symposium for Young Investigators in Memory of Dr. Robert Marquis to be Held March 10, 2015
Monday, March 2, 2015
Robert Marquis Mini-Symposium for Young Investigators
Tuesday, March 10, 2015
Hynes Convention Center, Boston, MA
About Robert Marquis
Dr. Robert E. Marquis, PhD, was chair of the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry, and a beloved teacher to many students who trained at the medical school and at the university’s College of Arts and Sciences. He died in January 2014 at the age of 80. Originally from Ontario, Canada, “Bob” earned his M.S. and PhD degrees from the University of Michigan in Ann Arbor. He spent two years as a post-doctoral fellow at the University of Edinburgh in Scotland, where he studied under the guise of Peter Mitchell, a British biochemist who was awarded the 1978 Nobel Prize in Chemistry.
Bob began his career at the University of Rochester in 1963 as a senior instructor in Microbiology and was continuously funded by the National Institutes of Health until his retirement as a professor in 2012. During his early years at the medical school, he studied energy transduction – how cells and bacteria develop energy from food. From the 1970s until the end of his career he focused on oral streptococci, a type of bacteria present in the mouth that are major contributors to tooth decay. He had a secondary appointment in the Center for Oral Biology and his work on the effects of fluoride on cavity-producing bacteria earned him international recognition and the 2006 Distinguished Scientist Award for Research in Dental Caries from the International Association for Dental Research.
As passionate as Bob was about his research, he was equally, if not more passionate about the colleagues, trainees, and students he worked with every day. He influenced the lives of many graduate students who considered him to be a remarkable colleague, mentor and friend. It is not surprising then that many of Bob’s graduate students went on to assume distinguished careers in academia, industry, or public health service.
Bob's influence also included undergraduate students on the University of Rochester’s River Campus, where he was a founding director of the Undergraduate Program in Biology and Medicine. This program combines the College of Arts and Sciences and the School of Medicine and Dentistry to provide courses for undergraduate students with lectures, laboratory work, specialty seminars and research experiences. Bob helped start the program in the early 1980’s and it led to the creation of the Bachelor’s of Science degrees in Biological Sciences, which includes tracks in Biochemistry, Cell and Developmental Biology, Ecology and Evolutionary Biology, Microbiology, Molecular Genetics, and Neuroscience. Thanks to Bob’s work, the program is a major conduit for undergraduate students into research labs at the medical school.
Outside of the University, Bob loved the Rochester Philharmonic Orchestra and was a huge fan of theater, traveling annually to the Shaw Festival in Niagara-on-the-Lake and the Shakespeare Festival in Stratford, Ontario. He was also known to fly to London with his wife on a regular basis to catch plays in London’s West End. Another hobby was custom brewing, an art that he shared and passed on to many.
This mini-symposium honors the memory of the late Robert E. Marquis and the knowledge he eagerly shared with students, trainees and early career faculty members. Its main objective is to promote information exchange among scientists who engage in oral microbiology and immunology research and clinical studies pertaining to oral health and disease, and to provide a forum through which new investigators entering the field can network with established investigators and so create contacts that can help nurture their research progress and productivity.
8:00 am Continental Breakfast and Sign-in
8:30 am Dr. Robert Quivey, PhD, Professor and Director, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY
“Well actually……, 40 years of bacterial physiology, from the late Robert E. Marquis.”
9:00 am Alejandro Aviles-Reyes, PhD candidate, (2015 recipient of the Arnold Bleiweis Travel Grant), University of Rochester School of Medicine and Dentistry, Rochester, NY
“S. mutans modification of Cnm by a novel glycolytic pathway”
9:25 am Dr. Roger M. Arce, DDS, MS, PhD, Assistant Professor, Dept. of Periodontics, College of Dental Medicine, Georgia Regents University, Augusta, GA
“Exploring the in-vivo effects of pathogen-differentiated dendritic cells”
9:50 am Dr. Lauren Mashburn Warren, PhD Senior Research Scientist, Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, Columbus, OH
“A novel approach to target the removal of caries-causing bacteria.”
10:15 am Dr. Octavio Gonzalez, DDS, MS, PhD, Assistant Professor, Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY “Adult and aged periodontitis: Two clinically similar but molecularly different lesions.”
10:40 am Dr. Peng Zhou, PhD, Associate Research Scientist, Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City, OK
“Role of veillonellae catalase in oral biofilm ecology”
11:05 am Dr. Brendaliz Santiago, PhD, Post-doctoral fellow, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY
“Amino acid metabolism: Acid adaptation and transcriptional regulation in S. mutans.”
11:30 am Natasha Singh, DDS candidate, University of Toronto Faculty of Dentistry, Toronto, Ontario, CANADA
“Development of a novel surveillance method to monitor bacterial biomarkers under chronic periodontitis.”
11:55 am Yun-ji Kim, Master’s candidate, School of Dentistry, Department of Oral Microbiology and Immunology, Seoul National University, Seoul, Republic of Korea
“Dysbiosis of oral microbiota in recurrent aphthous ulcers.”
12:20 pm Dr. Jessica Kajfasz, Postdoctoral Associate, Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY
“Transcription of oxidative stress genes is directly activated by SpxA proteins of Streptococcus mutans.”
12:45–1:15pm: Lunch and Discussion
1:20 pm Stephen Kasper, PhD candidate, (2015 recipient of the Susan Kinder Haake Award) SUNY College of Nanoscale Science and Engineering, University of Albany, Albany, NY
“Natural product-based nanocapsules for sustained delivery of anti-biofilm agents”
1:45 pm Josefine Hirschfeld, DMD, Periodontology Resident/Research Associate, University Hospital Bonn, Bonn, Germany
“Role of macrophage migration inhibitory factor in periodontal tissue destruction.”
2:10 pm Christina Sim, PhD candidate, National Dental Centre of Singapore, Singapore
“Development of an in vitro polymicrobial biofilm model of dental caries.”
2:35 pm Keum Jin Baek, Master’s candidate, School of Dentistry, Department of Oral Microbiology and Immunology, Seoul National University, Seoul, Republic of Korea
“Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis”
3:00 pm Dr. Zhimin Feng, Senior Instructor, Case Western Reserve School of Dental Medicine, Cleveland, OH
“Further studies of Acinetobacter baumannii interaction with human oral epithelial cells: Invasive capacity and induction of hBD3.”
3:25–3:35pm Coffee/Refreshment Break
3:35 pm Dr. Samta Jain, PhD, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA
“Trafficking of Porphyromonas gingivalis virulence factor Kgp to human endothelial cells.”
4:00 pm Dr. Kenneth Barth, PhD, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA
“Porphyromonas gingivalis gingipain-mediated modification of cellular kinases impairs host innate immune signaling.”
4:25 pm Dr. Carolyn Kramer, Postdoctoral Associate, Boston University Department of Medicine, Boston, MA
“The Oral Microbiome in Patients with Oral Cancers.”
4:50 pm Dr. George Papadopolous, PhD candidate, Boston University Department of Medicine, Boston, MA
“Pathogen-induced Th17 cells link oral infection with systemic inflammation.”
5:15 pm Concluding Remarks
E-Cigarette Vapors, Flavorings, Trigger Lung Cell Stress
Wednesday, February 11, 2015
Do electronic cigarettes help people quit smoking? As the debate continues on that point, a new University of Rochester study suggests that e-cigarettes are likely a toxic replacement for tobacco products.
Emissions from e-cigarette aerosols and flavorings damage lung cells by creating harmful free radicals and inflammation in lung tissue, according to the UR study published in the journal PLOS ONE. Irfan Rahman, Ph.D., professor of Environmental Medicine at the UR School of Medicine and Dentistry, led the research, which adds to a growing body of scientific data that points to dangers of e-cigarettes and vaping.
Please view the NBC news video about this article.Read More: E-Cigarette Vapors, Flavorings, Trigger Lung Cell Stress
E-cigarette Vapors Can Damage Lung Cells
Monday, February 9, 2015
A new study by University of Rochester suggests that e-cigarettes are likely to be a toxic replacement for tobacco products.
Emissions from e-cigarette aerosols and flavourings damage lung cells by creating harmful free radicals and inflammation in lung tissue.
Several leading medical groups, organizations and scientists are concerned about the lack of restrictions and regulations for e-cigarettes, said Irfan Rahman, lead author and professor of environmental medicine at University of Rochester Medical Center.
MSTP Announces 40th Anniversary Celebration!
Sunday, February 1, 2015
The Medical Scientist Training Program (MSTP) is excited to announce a celebration of the 40th anniversary of the MSTP NIH training grant on Friday, October 9, 2015.
The keynote speaker will be an MSTP alumni from the Class of 1980: Edward Rubin, MD, PhD, Director, DOE Joint Genome Institute.
Eddy Rubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Division in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI's involvement in the Human Genome Project (HGP).
For more information and schedule of events for the day, please visit the MSTP 40th Anniversary page.
Alejandro Avilés Reyes Receives 2015 Arnold Bleiweis Travel Award
Friday, January 30, 2015
Alejandro Avilés Reyes, a graduate student in the Lemos Lab and lab of Jacqueline Abranches, Ph.D., has been selected for the 2015 Arnold
Bleiweis Travel Award, to present his work entitled "Modification of
Streptococcus mutans Cnm by a novel glycosylation pathway". Mr. Avilés Reyes will give his presentation during the upcoming General Session of the International Association for Dental Research Conference, to be held March 10-14, 2015 in Boston, MA, as part of the first Robert Marquis Mini-Symposium for Young Investigators in Microbiology and Immunology.
Alejandro is currently working on the characterization of Cnm, a collagen-binding protein produced by invasive Streptococcus mutans. The Lemos-Abranches lab focuses on characterization of the stress-response mechanisms of Gram-positive bacteria and their contribution to virulence and disease.
UR Tests HIV Vaccine Pill
Tuesday, January 13, 2015
Researchers at the University of Rochester Medical Center are testing a new oral vaccine to prevent infection with HIV, the virus that causes AIDS. The vaccine is unique because it is given as a pill, unlike most HIV vaccines tested to date that have been given as shots
The study is funded and designed by Beth Israel Deaconess Medical Center (BIDMC), which received support for a Collaboration for AIDS Vaccine Discovery grant from the Bill & Melinda Gates Foundation. The URMC team and BIDMC are collaborating with the International AIDS Vaccine Initiative, which is helping to organize the study through its Vaccine Product Development Center to provide services to BIDMC grantees. This is one of the first studies to benefit from this partnership and URMC is the only center in the world testing this vaccine.Read More: UR Tests HIV Vaccine Pill
NIH Neuro Start Up Challenge
Monday, January 12, 2015
Several neuroscience graduate students and clinicians from the University of Rochester are involved in the NIH Neuro Start Up Challenge and have developed their elevator pitch and executive summary as part of the public voting phase. We encourage the neuroscience community to visit their Showcase page and provide votes and constructive feedback on the discussion board this week. Public voting will run Monday, January 12th through Friday, January 16th.
Team: University of Rochester- 8&9.A (Inventions 8 and 9)
Company Name: VasoMark
About the Challenge: The Neuro Start Up Challenge, launched by the NIH in partnership with the CAI and HPN, is designed to bring brain-related, patented technologies from the NIH to market. Teams of medical, scientific and business experts compete in several phases to create a company and
execute a business plan with the ultimate goal of launching their start-up.
Thank you for your support
New Study Probes Link Between HIV Drugs and Vascular Disease
Monday, January 5, 2015
A new $3.8 million grant will bring together clinical and bench researchers to better understand why individuals who receive anti-retroviral treatment for HIV are at greater risk for heart disease and stroke.
“The good news is that the drugs being used to fight HIV are increasing life expectancy to normal levels,” said University of Rochester neurologist Giovanni Schifitto, M.D., one of the co-leaders of the study. “However, one of the long-term complications is that these treatments, the infection itself, or a combination of the two are increasing risk for cardiovascular and cerebrovascular disease in this population.”Read More: New Study Probes Link Between HIV Drugs and Vascular Disease