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Education / Graduate Education / PhD Programs / Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

The Biochemistry & Molecular Biology (BMB) Program is designed for students interested in obtaining a Ph.D. in Biochemistry. As such, the program represents a group of faculty that may mentor a student pursuing thesis research toward the Biochemistry Ph.D. Students interested in a Ph.D. in Biochemistry should apply to the Biochemistry & Molecular Biology Program for admission to graduate studies at the University of Rochester Medical Center.

Chenguang Gong in Maquat Lab

Chenguang Gong working in the Maquat Lab

We offer in-depth coursework and diverse research opportunities that focus on understanding the biochemical mechanisms of life’s critical molecular processes.

World-class research in our laboratories exposes our students to a variety of the latest methods for sophisticated biochemical analysis, including mass spectrometry, crystallography, microcalorimetry, surface plasmon resonance, microarrays, fluorescence activated cell sorting, light scattering, and spectroscopic methods (including fluorescence lifetime and energy transfer measurements), as well as modern methods for cell culture, protein purification, genetic analysis, and reconstitution of biochemical complexes and reactions.

The flexibility of our training program allows students to train in a number of exciting research areas, and often allows students to develop highly effective interdisciplinary collaborations, resulting in cutting edge thesis projects.

NIH T32 Sponsored Programs

Training Grant in Cellular, Biochemical & Molecular Sciences

Graduate Women in Science (GWIS)

Research

We have several research areas, fully supported by an array of labs and centers. For a full view of our research efforts and Facilities, see our research page.

For a list of recent student publications, please visit the student publications page.

 

Events

Upcoming20172016201520142013

Development of Next-Gen PCR Technologies

Phillip Belgrader, Ph.D. - R&D Manager, Bio-Rad (formerly QuantaLife)
Jan 17, 2013 - 1:00 p.m.
Medical Center G-9425 (Class of '62 Aud.)
Host: Dr. Lynne Maquat (Co-sponsored by Graduate Women in Science)

Assembly and Dynamics of Uber Complex RNPs

Melissa Moore, Ph.D. - Investigator, Howard Hughes Medical Institute; Co-Director, RNA and Neuro Therapeutics Institutes; Professor, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
Feb 20, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Lynne Maquat (Co-sponsored by Graduate Women in Science)

Activation of the G Protein Coupled Receptor Rhodopsin: From Femtoseconds to Seconds

Oliver Ernst, Ph.D. - Professor, Department of Biochemistry, University of Toronto
Feb 27, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Lynne Maquat

Assessing and Validating Simulation Approaches to Model Nucleic Acid Structure and RNA-Ligand Interactions

Thomas Cheatham, III, Ph.D. - Associate Professor, Department of Medicinal Chemistry, College of Pharmacy, University of Utah
Mar 07, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. David Mathews

Reversible DNA and RNA Methylation in Biological Regulation

Chuan He, Ph.D. - Professor, Department of Chemistry; Director, Institute for Biophysical Dynamics, University of Chicago
Mar 13, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Yi-Tao Yu

Modulation of Folding Energy Landscape by Charge-Charge Interactions: Linking Experiments with Computational Modeling

George Makhatadze, Ph.D. - Senior Constellation Chaired Professor in Biocomputation and Bioinformatics; Professor, Department of Biology, Chemistry and Chemical Biology, Rensselaer Polytechnic Institute
Mar 20, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dimitri Ermolenko

The Role of MicroRNAs in Cancer: Cross-Talk with Antioxidant Genes

Jozef Dulak, Ph.D. D.Sc. - Professor and Head, Department of Medical Biotechnology, Jagiellonian University, Poland
Mar 27, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Mahin Maines

mRNA Surveillance is Driven by Translation

Rachel Green, Ph.D. - Investigator, Howard Hughes Medical Institute; Professor, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine
Apr 03, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

Cancer Metabolism: Cell Biology and Translational Opportunities

Ralph DeBerardinis, M.D. Ph.D. - Assistant Professor, Department of Pediatrics and Genetics, University of Texas Southwestern Medical Center
Apr 10, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Joshua Munger

Cryo-EM with Movies: Higher Resolution with Optimized Image Contrast

Nikolaus Grigorieff, Ph.D. - Investigator, Howard Hughes Medical Institute; Professor, Department of Biochemistry, Brandeis University
Apr 17, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

Using Computer Simulations to Investigate Dynamic Aspects of Inhibitor Binding and Potency

Carlos Simmerling, Ph.D. - Professor, Department of Chemistry, SUNY Stony Brook
Apr 24, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. David Mathews

The Structure and Viral Recognition Mechanisms of Surveillance Protein RIG-I

Anna Marie Pyle, Ph.D. - Investigator, Howard Hughes Medical Institute; Professor, Departments of Molecular, Cellular & Developmental Biology and Department of Chemistry, Yale University
May 01, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: T32 Training Grant Graduate Students (Joseph Liberman)

Structure and Dynamics of the Ribosome

Harry Noller, Ph.D. - Director, Center of Molecular Biology of RNA, University of California, Santa Cruz
May 08, 2013 - 1:00 p.m.
Medical Center G-9425 (Class of '62 Aud.)
Host: Drs. Lynne Maquat, Dmitri Ermolenko and Gloria Culver

Circadian Components as Modulators of Cell Cycle Signaling

Carla Finkielstein, Ph.D. - Associate Professor, Department of Biological Sciences, Virginia Polytechnic Institute
May 22, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Mahin Maines

Controlling Biology By Protein Design

Shohei Koide, Ph.D. - Professor, Department of Biochemistry and Molecular Biology, The University of Chicago
May 29, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Jeffrey Hayes

APOBEC3 Proteins: role in sexual transmission of retroviruses

Chioma Okeoma, Ph.D. - Assistant Professor, Department of Microbiology and Interdisciplinary Graduate Program in Molecular & Cellular Biology, The University of Iowa
Jul 15, 2013 - 4:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Harold Smith

Adapting to Stress: Lessons from a Model Organism

James R. Broach, Ph.D. - Director, Penn State Hershey Institute for Personalized Medicine, Chair, Department of Biochemistry and Molecular Biology at Penn State Professor Emeritus of Princeton University
Jul 17, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Jeffrey Hayes

Trinucleotide Repeat Instability via DNA Base Lesion Repair

Yuan Liu, Ph.D. - Assistant Professor, Department of Chemistry and Biochemistry School of Integrated Science and Humanity Florida International University
Aug 07, 2013 - 10:00 a.m.
Medical Center 1-6823 (Neuman Conference Room)
Host: Dr. Jeffrey Hayes

The Importance of Being Modified: How Modified Nucleosides Influence Codon Usage

Paul Agris, Ph.D. - Professor, Department of Biological Sciences and Chemistry; Director, The RNA Institute; SUNY Albany
Sep 18, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Joseph Wedekind (Co-Sponsored by the Clinical and Translational Science Institute & the RNA Structure and Function Cluster)

Neurexins - Synaptic Organizers Implicated in Neurological Disease

Gabrielle Rudenko, Ph.D. - Research Assistant Professor, Life Sciences Institute; Assistant Professor, Department of Pharmacology; University of Michigan Medical School
Sep 23, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Jeffrey Hayes

The Role of PARP-1 in Chromatin-Mediated Gene Regulation: Control of Cellular Signaling and Differentiation Programs

W. Lee Kraus, Ph.D. - Director, Cecil H. and Ida Green Center for Reproductive Biology Sciences; Professor and Vice Chair for Basic Science, Department of Ob/Gyn; Professor, Department of Pharmacology; Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences; UT Southwestern Medical Center at Dallas
Sep 25, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Michael Bulger (Co-Sponsored by the Department of Environmental Medicine)

Normal and Unusual Decoding by the Ribosome

Venkatraman Ramakrishnan, Ph.D. - Medical Research Council Laboratory of Molecular Biology; Cambridge Biomedical Campus; Cambridge, England
Oct 02, 2013 - 2:00 p.m.
Medical Center G-9425 (Class of '62 Aud.)
Host: Dr. Yi-Tao Yu (Co-sponsored by the RNA Structure and Function Cluster & Graduate Women in Science)

Clock Proteins: New Players in DNA-Damage Signaling

Carla Finkielstein, Ph.D. - Associate Professor, Department of Biological Sciences; Virginia Polytechnic Institute
Oct 09, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Mahin Maines

Spliceosome Assembly and Activity

Andrew MacMillan, Ph.D. - Professor, Department of Biochemistry; University of Alberta
Oct 16, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Clara Kielkopf

Identification of a New RNA Degradation Machine: A Bedside to Bench Story

Sandra Wolin, M.D.,Ph.D. - Professor of Cell Biology and Molecular Biophysics and Biochemistry and Vice Chair of the Department of Cell Biology, Yale University School of Medicine
Oct 21, 2013 - 3:00 p.m.
Medical Center 2-6408 (K-207 Aud)

Using Computer Simulations to Investigate Dynamic Aspects of Inhibitor Binding and Potency

Carlos Simmerling, Ph.D. - Professor, Department of Chemistry; SUNY Stony Brook
Oct 23, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. David Mathews

When Chromatin Assembly Goes Awry

Jessica Tyler, Ph.D. - Professor, Department of Biochemistry and Molecular Biology; The University of Texas MD Anderson Cancer Center
Oct 30, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Michael Bulger and Dr. Lata Balakrishnan

Test Driving the 60S Ribosomal Subunit

Arlen Johnson, Ph.D. - Professor, Department of Molecular Biosciences; The University of Texas at Austin
Nov 06, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Eric Phizicky

RNA Sensors and Global Metabolic Regulation

Martha Fedor, Ph.D. - Editor in Chief, Journal of Biological Chemistry; Professor, Department of Chemical Physiology, Department of Cell and Molecular Biology, and The Skaggs Institute for Chemical Biology; The Scripps Research Institute
Nov 20, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Lynne Maquat (Co-sponsored by Graduate Women in Science)

Communicating Science in the 21st Century

Martha Fedor, Ph.D. - Editor in Chief, Journal of Biological Chemistry; Professor, Department of Chemical Physiology, Department of Cell and Molecular Biology, and The Skaggs Institute for Chemical Biology; The Scripps Research Institute
Nov 21, 2013 - 1:00 p.m.
Medical Center G-9425 (Class of '62 Auditorium)
Host: Dr. Lynne E. Maquat

An Unforeseen Path to a Fortuitous End

Martha Fedor, Ph.D. - Editor in Chief, Journal of Biological Chemistry; Professor, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA
Nov 21, 2013 - 3:00 p.m.
Medical Center 1-9576 (Case Method Room)
Host: Dr. Lynne E. Maquat

Structural Insights into Novel Deoxysugar Biosynthesis in Bacteria

Hazel Holden, Ph.D. - Professor, Department of Biochemistry; University of Wisconsin-Madison
Dec 18, 2013 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Joseph Wedekind (Co-sponsored by Graduate Women in Science)

Event Photos