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Education / Graduate Education / PhD Programs / Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

The Biochemistry & Molecular Biology (BMB) Program is designed for students interested in obtaining a Ph.D. in Biochemistry. As such, the program represents a group of faculty that may mentor a student pursuing thesis research toward the Biochemistry Ph.D. Students interested in a Ph.D. in Biochemistry should apply to the Biochemistry & Molecular Biology Program for admission to graduate studies at the University of Rochester Medical Center.

Chenguang Gong in Maquat Lab

Chenguang Gong working in the Maquat Lab

We offer in-depth coursework and diverse research opportunities that focus on understanding the biochemical mechanisms of life’s critical molecular processes.

World-class research in our laboratories exposes our students to a variety of the latest methods for sophisticated biochemical analysis, including mass spectrometry, crystallography, microcalorimetry, surface plasmon resonance, microarrays, fluorescence activated cell sorting, light scattering, and spectroscopic methods (including fluorescence lifetime and energy transfer measurements), as well as modern methods for cell culture, protein purification, genetic analysis, and reconstitution of biochemical complexes and reactions.

The flexibility of our training program allows students to train in a number of exciting research areas, and often allows students to develop highly effective interdisciplinary collaborations, resulting in cutting edge thesis projects.

NIH T32 Sponsored Programs

Training Grant in Cellular, Biochemical & Molecular Sciences

Graduate Women in Science (GWIS)

Research

We have several research areas, fully supported by an array of labs and centers. For a full view of our research efforts and Facilities, see our research page.

For a list of recent student publications, please visit the student publications page.

 

Events

Upcoming20172016201520142013

The Role of RNA- and DNA-Binding Proteins in Post-Transcriptional Gene Regulation and Innate Immunity

Manuel Ascano, Jr. Ph.D. - Postdoctoral Associate, Laboratory of RNA Molecular Biology at the Rockefeller University
Jan 08, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Small RNA Sorting is Critical for Germline Surveillance and Fertility

Carolyn Phillips, Ph.D. - Postdoctoral Associate, Department of Molecular Biology at Massachusetts General Hospital and Department of Genetics at Harvard Medical School
Jan 13, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Assessing the Orientation of Vaccine Candidate P6 in Nontypable Haemophilus Influenza

Lea Vacca Michel, Ph.D. - Assistant Professor, School of Chemistry and Materials Science, Rochester Institute of Technology
Jan 15, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. David Mathews

Student Seminar (BPH 572) for Yinghan Fu

Yinghan Fu - PhD Candidate(s)
Jan 21, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Unraveling the Effects of microRNAs: Targets and mRNP Remodeling

Olivia Rissland, D.Phil. - Postdoctoral Fellow, Whitehead Institute for Biomedical Research
Jan 22, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Mechanistic Studies of Eukaryolic Translation Initiation

Sarah Walker - Postdoctoral Fellow, Department of Biophysics and Biophysical Chemistry at John Hopkins University School of Medicine; Research Fellow in the Intramural Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the NIH
Jan 27, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Student Seminar (BPH 572) for Nicholas Leioatts

Nicholas Leioatts - PhD Candidate(s)
Jan 28, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Stefanie DeVito and Chinmay Surve

Stefanie DeVito and Chinmay Surve - PhD Candidate(s)
Feb 04, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Stefanie DeVito and Chinmay Surve

Stefanie DeVito and Chinmay Surve - PhD Candidate(s)
Feb 04, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Integrative Approaches for Decoding the Function of Long Non-coding RNAs in Human Cancer

Yiwen Chen, Ph.D. - Postdoctoral Fellow, Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Harvard School of Public Health
Feb 10, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Student Seminar (BPH 572) for Dejun Lin and Sarah Loerch

Dejun Lin and Sarah Loerch - PhD Candidate(s)
Feb 11, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BPH 572) for Dejun Lin and Sarah Loerch

Dejun Lin and Sarah Loerch - PhD Candidate(s)
Feb 11, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

piRNA Primary Transcripts: A New Class of Long Non-coding RNA

Xin Zhiguo Li, Ph.D. - Postdoctoral Associate, University of Massachusetts, Medical School/HHMI
Feb 17, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)

Student Seminar (BCH 502) for Yongchun Zhang and John Vadas

Yongchun Zhang and John Vadas - PhD Candidate(s)
Feb 18, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Yongchun Zhang and John Vadas

Yongchun Zhang and John Vadas - PhD Candidate(s)
Feb 18, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Science and News: A Marriage of Convenience

Joe Palca, Ph.D. - Science Correspondent, NPR News, Washington, D.C.
Feb 20, 2014 - 1:00 p.m.
Medical Center G-9425 (Class of '62 Auditorium)
Host: Dr. Lynne E. Maquat

Student Seminar (BCH 502) for Shihao Xu and Clarence Ling

Shihao Xu and Clarence Ling - PhD Candidate(s)
Feb 25, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Shihao Xu and Clarence Ling

Shihao Xu and Clarence Ling - PhD Candidate(s)
Feb 25, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Synthetic Molecular Evolution of Membrane Active Peptides

William C. Wimley, Ph.D. - Department of Biochemistry, Tulane University School of Medicine
Feb 26, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Alan Grossfield

Student Seminar (BCH 502) for Christina Brule and Jerry Madukwe

Christina Brule and Jerry Madukwe - PhD Candidate(s)
Mar 04, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Christina Brule and Jerry Madukwe

Christina Brule and Jerry Madukwe - PhD Candidate(s)
Mar 04, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Mechanisms of Human Translation and mRNA Turnover Regulation

Jens Lykke-Andersen, Ph.D. - Professor, Division of Biological Science, University of California, San Diego
Mar 05, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Yi-Tao Yu

Student Seminar (BCH 502) for Matthew Payea and Morgan Monaghan

Matthew Payea and Jerry Madukwe - PhD Candidate(s)
Mar 11, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Matthew Payea and Morgan Monaghan

Matthew Payea and Jerry Madukwe - PhD Candidate(s)
Mar 11, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Stepwise Analysis of RNA Interference by Single Molecule and Single Cell Platform

Sua Myong, Ph.D. - Assistant Professor, Bioengineering Department, University of Illinois, Urbana Champaign
Mar 12, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

Student Seminar (BPH 572) for Rakesh Chatrikhi and Mallory Scott

Rakesh Chatrikhi and Mallory Scott - PhD Candidate(s)
Mar 18, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BPH 572) for Rakesh Chatrikhi and Mallory Scott

Rakesh Chatrikhi and Mallory Scott - PhD Candidate(s)
Mar 18, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Mechanism and Regulation of DNA Double-Strand Break Repair

Lorraine Symington, Ph.D. - Professor, Department of Microbiology and Immunology, Columbia University
Mar 19, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Elaine Sia and Lynne Maquat

Using Microsoft Word to Format Your Dissertation

Patrick Brandt, Ph.D. - Director of Science, Training and Diversity, University of North Carolina School of Medicine and Dentistry
Mar 21, 2014 - 9:00 a.m.
Medical Center 1-6823 (Neuman Room)

Thinking Strategically About Your Postdoc Training

Patrick Brandt, Ph.D. - Director of Science, Training and Diversity, University of North Carolina School of Medicine and Dentistry
Mar 21, 2014 - 4:00 p.m.
Helen Wood Hall 1W304

Student Seminar (BCH 502) for Thomas Hilimire and Owen Smith

Morgan Monaghan and Owen Smith - PhD Candidate(s)
Mar 25, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Thomas Hilimire and Owen Smith

Morgan Monaghan and Owen Smith - PhD Candidate(s)
Mar 25, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BPH 572) for Karl Smith and Bronwyn Lucas

Karl Smith and Amber Cutter - PhD Candidate(s)
Apr 01, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BPH 572) for Karl Smith and Bronwyn Lucas

Karl Smith and Amber Cutter - PhD Candidate(s)
Apr 01, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

eIF5A Promotes Polyproline Protein Production

Thomas Dever, Ph.D. - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Apr 02, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Christina Brule

Student Seminar (BPH 572) for Kyle Berger and Amber Cutter

Kyle Berger and Bronwyn Lucas - PhD Candidate(s)
Apr 08, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BPH 572) for Kyle Berger and Amber Cutter

Kyle Berger and Bronwyn Lucas - PhD Candidate(s)
Apr 08, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

How Enzymes Work

Dan Hershlag, Ph.D. - Professor of Biochemistry, Chemistry and of Chemical Engineering; Senior Associate Dean of Graduate Education and Postdoctoral Affairs, Stanford University
Apr 09, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Joseph Wedekind

Student Seminar (BCH 502) for Michael Sloma and Lu Han

Michael Sloma and Lu Han - PhD Candidate(s)
Apr 15, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 502) for Michael Sloma and Lu Han

Michael Sloma and Lu Han - PhD Candidate(s)
Apr 15, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Story in a Sample: How cryo-EM Unravels Multiple States of the Ribosome in a Single Experiment

Joachim Frank, Ph.D. - Professor, Department of Biological Sciences and Molecular Biophysics, Columbia University, and Howard Hughes Medical Institute Investigator
Apr 16, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

The Dark Side of Functional Genomics and a New Hope: Genome-Wide Screens with RNAi and CRISPR

John Doench, Ph.D. - Research Scientist, Broad Institute of MIT and Harvard
Apr 23, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. David Mathews

Liver Inflammation and Cancer

Michael Karin, Ph.D. - Professor of Pharmacology, University of California, San Diego
Apr 30, 2014 - 2:00 p.m.
Medical Center 1-9576 (Case Method Room)
Host: Dr. Mahin Maines

The Metabolic Code

Brian Shoichet, Ph.D. - Professor, Faculty of Pharmacy, University of Toronto; Professor, Department of Pharmaceutical Chemistry, University of California, San Francisco; Member of the Donnelly Centre, University of Toronto
May 07, 2014 - 1:00 p.m.
Medical Center G-9425 (Class of '62 Auditorium)
Host: Drs. Sina Ghaemmaghami and Lynne Maquat

Student Seminar (BCH 501/BPH 571) for Angela Balliano

Eric Phizizky & Angela Balliano - PhD Candidate
Sep 09, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 501/BPH 571) for Angela Balliano

Eric Phizizky & Angela Balliano - PhD Candidate
Sep 09, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 501/BPH 571) for Rajashri Sridharan

Rajashri Sridharan - PhD Candidate
Sep 16, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

eIF3: a Bridge Between Translation and Transcription

Jamie Cate, Ph.D. - Professor, Departments of Molecular & Cell Biology and Chemistry, University of California, Berkeley
Sep 17, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

eIF3: a Bridge Between Translation and Transcription

Jamie Cate, Ph.D. - Professor, Departments of Molecular & Cell Biology and Chemistry, University of California, Berkeley
Sep 17, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko (Co-sponsored by Graduate Women in Science)

Student Seminar (BCH 501/BPH 571) for Guangze Jin

Guangze Jin - PhD Candidate
Sep 23, 2014 - 1:00 p.m.
Medical Center 1-7619 (Adolph Auditorium)

Innovations in Research Impact Measurement and Literature Discovery

Kinga Hosszu, Ph.D. - Outreach Director - F1000 Americas, Faculty of 1000, New York, NY
Sep 24, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Dmitri Ermolenko

Student Seminar (BCH 501/BPH 571) for Dhruba Jyoti Basu Roy

Dhruba Jyoti Basu Roy - PhD Candidate
Sep 30, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Flavivirus (Dengue, West Nile, etc.) - Caused Disease Depends on Structured RNA Wrenches Thrown into Protein Machines

Jeffrey Kieft, Ph.D. - Professor, Howard Hughes Medical Institute, Department of Biochemistry & Molecular Genetics, University of Colorado Denver, School of Medicine
Oct 01, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Joseph Wedekind

Effects of non-histone protein HMGN1 on histone tail domain interactions and H1 binding in chromatin

Kevin Murphy - PhD Candidate
Oct 07, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Transcription and the Three-Dimensional Organization of the Genome

Victor Corces, Ph.D. - Professor, Howard Hughes Medical Institute
Oct 08, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: T32 Training Grant Graduate Students (Amber Cutter)

Investigating the role of PGE2 receptor subtype 1 (EP1) in Mesenchymal Stem Cell (MSC) differentiation

Marina Feigenson - PhD Candidate
Oct 14, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Long Lost Relatives: The Expanding PUF Protein Family

Traci Hall, Ph.D. - Senior Investigator, Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC
Oct 15, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Clara Kielkopf (Co-sponsored by Graduate Women in Science)

Long Lost Relatives: The Expanding PUF Protein Family

Traci Hall, Ph.D. - Senior Investigator, Laboratory of Structural Biology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Research Triangle Park, North Carolina
Oct 15, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Clara Kielkopf

Student Seminar (BCH 501/BPH 571) for He Fang

He Fang - PhD Candidate
Oct 21, 2014 - 1:00 p.m.
Medical Center 1-7619 (Adolph Auditorium)

ERKonomics in Metabolic Signaling

Melanie Cobb, Ph.D. - Professor, Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX
Oct 22, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Mahin Maines

Student Seminar (BCH 501/BPH 571) for Yinghan Fu

Yinghan Fu - PhD Candidate
Oct 28, 2014 - 1:00 p.m.
Medical Center 3-7616 (Upper S-Wing Auditorium)

Structural Analyses of RNA-Small Molecule Interactions: Bacterial Riboswitches and Engineered Devices

Adrian R. Ferré-D'Amaré, Ph.D. - Senior Investigator, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda MD
Oct 29, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Eric Phizicky

Student Seminar (BCH 501/BPH 571) for Chinmay Surve

Chinmay Surve - PhD Candidate
Nov 04, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Structural Studies of Bacterial Transcription

Seth Darst, Ph.D. - Jack Fishman Professor, Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY
Nov 05, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Clara Kielkopf & Dr. Michael Gleghorn (Co-sponsored by the RNA Structure and Function Cluster)

Coordinated Responses to Nutritional Metal Stress by Heme-Dependent Gene Expression

Mark O'Brian, Ph.D. - Professor and Interim Chair, Department of Biochemistry, State University of New York at Buffalo
Nov 12, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Mahin Maines

HCMV-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation

Stefanie DeVito - PhD Candidate
Nov 18, 2014 - 1:00 p.m.
Medical Center 1-7619 (Adolph Auditorium)

The Molecular Tool-Kit of Viral Hemorrhagic Fevers

Erica Ollmann Saphire, Ph.D. - Professor of Immunology and Microbial Science, Scripps Research Institute, California Campus
Nov 19, 2014 - 12:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)
Host: Joshua Munger & Luis Martinez-Sobrido

Oncogenic mutations-induced restriction to HCMV infection

Shihao Xu - PhD Candidate
Nov 25, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Student Seminar (BCH 501/BPH 571) for Dejun Lin

Dejun Lin - PhD Candidate
Dec 02, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

The Ribosome Determines mRNA Stability

Jeff Coller, Ph.D. - Associate Professor and Associate Director, Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH
Dec 03, 2014 - 2:00 p.m.
Medical Center 3-6408 (K-307)
Host: Dr. Eric Phizicky

Student Seminar (BCH 501/BPH 571) for Yongchun Zhang

Yongchun Zhang - PhD Candidate
Dec 09, 2014 - 1:00 p.m.
Medical Center 3-7619 (Upper S-Wing Auditorium)

Event Photos