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Education / Graduate Education / PhD Programs / Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

The Biochemistry & Molecular Biology (BMB) Program is designed for students interested in obtaining a Ph.D. in Biochemistry. As such, the program represents a group of faculty that may mentor a student pursuing thesis research toward the Biochemistry Ph.D. Students interested in a Ph.D. in Biochemistry should apply to the Biochemistry & Molecular Biology Program for admission to graduate studies at the University of Rochester Medical Center.

Chenguang Gong in Maquat Lab

Chenguang Gong working in the Maquat Lab

We offer in-depth coursework and diverse research opportunities that focus on understanding the biochemical mechanisms of life’s critical molecular processes.

World-class research in our laboratories exposes our students to a variety of the latest methods for sophisticated biochemical analysis, including mass spectrometry, crystallography, microcalorimetry, surface plasmon resonance, microarrays, fluorescence activated cell sorting, light scattering, and spectroscopic methods (including fluorescence lifetime and energy transfer measurements), as well as modern methods for cell culture, protein purification, genetic analysis, and reconstitution of biochemical complexes and reactions.

The flexibility of our training program allows students to train in a number of exciting research areas, and often allows students to develop highly effective interdisciplinary collaborations, resulting in cutting edge thesis projects.

NIH T32 Sponsored Programs

Training Grant in Cellular, Biochemical & Molecular Sciences

Graduate Women in Science (GWIS)

Research

We have several research areas, fully supported by an array of labs and centers. For a full view of our research efforts and Facilities, see our research page.

For a list of recent student publications, please visit the student publications page.

 

Events

Upcoming20172016201520142013

Regulation of Reversible Phosphorylation in Synaptic Plasticity and Memory Formation

Hugh Xia, M.Sc., Ph.D. - Paul Stark Professor of Pharmacology; Associate Professor, Departments of Pharmacology & Physiology and Neuroscience, University of Rochester, Rochester, NY
Jan 11, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Dissecting the Function of Domain-Forming Transcriptional Enhancers

Sierra Fox - PhD Candidate
Jan 24, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Investigating Genome-wide Patterns of Secondary Structure in mRNA Sequences

Mohammad Kayedkhordeh - PhD Candidate
Jan 24, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Relating RNA Structure to Regulatory Conformation in Live Cells

Debapratim Dutta - PhD Candidate
Jan 31, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

HCMV and Immunity: UL26 Interactions with NFkB and ISGylation Pathways

Christopher Goodwin - PhD Candidate
Jan 31, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Exploring the Link between Longevity and DNA Double Strand Break Repair Coordination by SIRT6

Steven Henderson - PhD Candidate
Feb 07, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Characterization of Opsin's Activation Mechanism Using Multi-basin Structure-based Models

Letty Salas Estrada - PhD Candidate
Feb 07, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Model RNA Secondary Structure with Sequence Comparison and Experimental Mapping Data

Zhen Tan - PhD Candidate
Feb 14, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Pathological Vascular Remodeling

Lingfeng Luo - PhD Candidate
Feb 14, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Yeast Cell Surface Display of HIV Envelope Glycoprotein for Vaccine Development

Hong Zhu - PhD Candidate
Feb 21, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Defining Mechanisms that Maintain Reading Frame in Eukaryotic Translation

Jiyu Wang - PhD Candidate
Feb 21, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Benchmarking RNA Force Fields using Hairpin Loop Folding Free Energy Change

Louis Smith - PhD Candidate
Feb 28, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Coactivator PGC1β Contains a Novel CBP80-Binding Motif That Orchestrates Efficient Target-Gene Transcription and Transcript Splicing

Christopher Phipps - PhD Candidate
Feb 28, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Diversity in Post-Transcriptional Modifications: Adaptive or Not?

Jianzhi - Marshall W. Nirenberg Collegiate Professor, Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI
Mar 01, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Substrate Recognition by Box H/ACA RNA Guided Pseudouridylation

Meemanage De Zoysa - PhD Candidate
Mar 07, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Communication between the Core Histone Tails and H1 Carboxyl-Terminal Domain

Fanfan Hao - PhD Candidate
Mar 07, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Mechanisms of RNA-based Immunity in Prokaryotes

Ailong Ke, Ph.D. - Associate Professor, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY
Mar 08, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Mechanism-Based Antisense Therapy for Spinal Muscular Atrophy

Adrian R. Krainer, Ph.D. - St. Giles Foundation Professor of Molecular Genetics and Program Chair, Cancer & Molecular Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Mar 15, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

A Novel Method for Probing Chromatin Accessibility

Luke Marr - PhD Candidate
Mar 21, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Genomic Mechanisms of Gene Regulation and Chromatin Organization

Frank Pugh, Ph.D. - Professor, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA
Mar 22, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

The Role of Yeast Met22 and pAp Signaling in Rapid tRNA Decay

Thareendra De Zoysa - PhD Candidate
Mar 28, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Defining Context Specific Gene Sets for Deconvolution and Pathway Analysis

Lauren Benoodt - PhD Candidate
Mar 28, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Seeds for Collaboration: Faculty Mixer

David Auerbach, Ph.D., Danielle Benoit, and Eric Phizicky
Mar 28, 2017 - 4:30 p.m.
Medical Center LeChase Assembly Room G-9576

Specialized Translation Mechanisms by microRNAs in Cancer Quiescence

Shobha Vasudevan, Ph.D. - Assistant Professor, Department of Medicine, Harvard Medical School; Assistant in Genetics, Massachusetts General Hospital Center for Cancer Research, Boston, MA
Mar 29, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Disrupting the Erythroid Enhancer for Setd8 in Human Hematopoietic Stem/Progenitor Cells with CRISPR/Cas9

Tyler Couch - PhD Candidate
Apr 04, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Strategies for Enhancing Permeability and Specificity of RNA-targeted Anti-HIV Compounds

Viktoriya Anokhina - PhD Candidate
Apr 04, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

LncRNA Control of Heart Development and Disease

Doug M. Anderson, Ph.D. - Assistant Professor, Department of Medicine, Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY
Apr 05, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Mechanisms of Codon-mediated Inhibition of Translation

Lisa Houston - PhD Candidate
Apr 11, 2017 - 1:00 p.m.
Medical Center Whipple (2-6424)

Multiplex Detection of Biomarkers for Sepsis by Monolithically Integrated Photonic Microring Resonator Biosensors in a Hand-held Device

Michael Bryan - PhD Candidate
Apr 11, 2017 - 1:30 p.m.
Medical Center Whipple (2-6424)

How RNA Structures ‘Jiggle and Wiggle’ at Atomic Resolution: Importance to Function and Drug Discovery

Hashim Al-Hashimi, Ph.D. - James B. Duke Professor of Biochemistry, Director, Duke Center for RNA Biology, Duke University School of Medicine, Durham, NC
Apr 12, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Conformational dynamics of an HIV-1 RNA hairpin bound to a lab-evolved peptide

Chapin Cavender - PhD Candidate
Apr 18, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

The Roles of Histone H2A Variants in Erythroid Maturation

Nazish Jeffery - PhD Candidate
Apr 18, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Exploration of CRISPR Diversity: from Microbiology to Biotechnology

Feng Zhang, Ph.D. - Associate Professor, Department of Biological Engineering and Brain and Cognitive Sciences; Core Member, Broad Institute of MIT, Cambridge, MA
Apr 19, 2017 - 1:00 p.m.
Medical Center Class of ’62 Aud (G-9425)

Investigating Methyltransferase Activity of PRDM3

Yuliya Muradova - PhD Candidate
Apr 25, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Regulation of Protein Synthesis by mRNA Structure

Wan-Jung Lai - PhD Candidate
Apr 25, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Ribosomal RNA Modification and Bacterial Antibiotic Resistance

Graeme L. Conn, Ph.D. - Associate Professor, Department of Biochemistry, Emory University School of Medicine, Atlanta, GA
Apr 26, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Identifying a Phospholipase Cε Region that Interacts with Gβγ

Jerry Madukwe - PhD Candidate
May 02, 2017 - 1:00 p.m.
Medical Center S-Wing Auditorium (3-7619)

Proportional Boolean Networks for Pathway Analysis of omicsData

Rohith Palli - PhD Candidate
May 02, 2017 - 1:30 p.m.
Medical Center S-Wing Auditorium (3-7619)

Mechanism and Dysfunction of Spliceosome Assembly

Aaron Hoskins, Ph.D. - Assistant Professor, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI
May 03, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

A Journey In and Out of Science and the Challenges of Career Re-entry

Jane Skok, Ph.D. - Professor, Department of Pathology, NYU School of Medicine, New York, NY
May 15, 2017 - 3:00 p.m.
Medical Center Lower Adolph Aud 1-7619

Uncovering Novel Capabilities of Acid Sensing Ion Channels

David M. MacLean, Ph.D. - Assistant Professor, Department of Pharmacology & Physiology, University of Rochester, Rochester, NY
May 31, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

From U of R to Tenure-Track: Teaching and Research at a Small Liberal Arts

Emily Desmet Ledgerwood, Ph.D. - Assistant Professor, Department of Biological Sciences Le Moyne College, Syracuse, NY
Sep 21, 2017 - 3:00 p.m.
Medical Center 1-9576 Ryan Case Method Room
Host: Dr. Lynne Maquat

Unraveling the Role of RNA Structure in Gene Regulation Through Studies of the RNA Helicase Dbp2/DDX5

Elizabeth J. Tran, Ph.D. - Associate Professor, Department of Biochemistry, Purdue University, West Lafayette, IN
Sep 27, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

mRNA and tRNA Modifications in the Regulation of Gene Expression

Tao Pan, Ph.D. - Professor, Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL
Oct 04, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

tRNA Splicing and Subcellular Dynamics

Anita Hopper, Ph.D. - Professor, Department of Molecular Genetics, The Ohio State University, Columbus, OH
Oct 11, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Academic Science: Amazing Career Opportunities

Anita Hopper, Ph.D. - Professor, Department of Molecular Genetics The Ohio State University, Columbus, OH
Oct 12, 2017 - 3:00 p.m.
Medical Center 1-7619 Adolph Lower Auditorium
Host: Dr. Lynne Maquat

Diverse Biology of tRNA-Derived Fragments

Pavel Ivanov, Ph.D. - Assistant Professor, Department of Medicine, Harvard Medical School, Boston, MA; Associate Immunologist, Brigham and Women’s Hospital, Boston, MA; Associate Member, The Broad Institute of Harvard and M.I.T., Cambridge, MA
Oct 18, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Emerging Roles for mRNA Polyadenylation in Stem Cells

Yongsheng Shi, Ph.D. - Associate Professor, Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA
Oct 25, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Small and Bright: Tailoring Luminescent Nanoparticles in Biology

Gang Han, Ph.D. - Associate Professor, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA
Nov 01, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Establishing and Maintaining Epigenetic Memories

Danesh Moazed, Ph.D. - Investigator, HHMI; Professor, Department of Cell Biology, Harvard Medical School, Boston, MA
Nov 08, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Designer Spliceosomes and Disease

Charles Query, M.D. Ph.D. - Professor, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
Nov 15, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Latching on and Moving Forward: Career Advice from the Ribosome

Sarah Walker, Ph.D. - Assistant Professor, Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY
Nov 16, 2017 - 3:00 p.m.
Medical Center 1-9576 Ryan Case Method Room
Host: Dr. Dmitri Ermolenko

Satellite DNA and Meiotic Drive in Drosophila

Amanda M. Larracuente, Ph.D. - Assistant Professor, Department of Biology, University of Rochester, Rochester, NY
Nov 29, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Metabolic Influences on RNA Biology

Benjamin Tu,Ph.D. - Associate Professor, Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX
Dec 06, 2017 - 2:00 p.m.
Medical Center K-307 (3-6408)

Event Photos