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Research

Cell Biology

Cell BiologyMicrobes and viruses interact with host cells to induce alterations in cellular phenotype and function, thereby subverting host cell metabolism to meet their own needs. In addition, many microbes and viruses exert effects on the host immune response, so as to evade host immune control. Knowledge of the interplay between infectious pathogens and their host cells is therefore important, in order to identify potential new targets for drug therapy and as a basis for understanding microbial pathogenesis. Research focuses on various aspects of mammalian and amphibian cell biology including, cell to cell interactions, cell cycle control, intracellular signaling, differentiation and subcellular organelles.

Active Research Laboratories

  • Zhu Lab - Host-Virus Interactions, Particularly for HIV and Herpes Viruses

DNA Replication, Repair & Recombination

DNA Replication, Repair & RecombinationThe fundamental processes DNA undergoes during the cell cycle to both maintain the integrity of the DNA and create genetic diversity.

Active Research Laboratories

  • Bi Lab - Chromatin Regulation of Gene Expression in Eukaryotes
  • Gorbunova Lab - Aging, DNA repair, and Cancer
  • Hayes Lab - Chromatin Structure
  • Sia Lab - Mutagenesis and Repair of Mitochondrial DNA

Gene Regulation

Gene RegulationProcesses that cells and viruses use to turn the information in genes into gene products.

Active Research Laboratories

  • Bi Lab - Chromatin Regulation of Gene Expression in Eukaryotes
  • Bohmann Lab - JNK, Fos, Foxo and Nrf2 Dependent Signaling and Gene Regulation in Oxidative Stress Response and Aging
  • Bulger Lab - Chromatin Domains and Enhancer Activation
  • Butler Lab - Regulation of Gene Expression by Targeted Degradation of RNA
  • Grayhack Lab - The Roles of the Genetic Code in Translation
  • Gorbunova Lab - Aging, DNA repair, and Cancer
  • Hayes Lab - Chromatin Structure
  • Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
  • Li Lab - Reproductive and RNA Biology
  • Steiner Lab - Understanding the molecular mechanisms underlying the development of red blood cells in both normal and disease states
  • Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
  • Yu Lab - Functions & Mechanisms of RNA Modifications
  • Zhao Lab - Cell Proliferation and Mammalian Cells
  • Zhu Lab - Host-Virus Interactions, Particularly for HIV and Herpes Viruses

Molecular Mechanisms in Cell Function and Disease

Molecular Mechanisms in Cell Function and DiseaseInvestigate the molecular mechanisms that govern cell function and are responsible for pathological processes.

Active Research Laboratories

  • Bohmann Lab - JNK, Fos, Foxo and Nrf2 Dependent Signaling and Gene Regulation in Oxidative Stress Response and Aging
  • Brookes Lab - Cardiac Ischemia-Reperfusion (IR) Injury and Cardioprotection
  • Dickerson Lab - CGRP Signal Transduction
  • Ermolenko Lab - Structural Dynamics of Translation
  • Ghaemmaghami Lab - Mechanisms of protein folding and degradation within cells
  • Goldfarb Lab - Nuclear Transport and Autophagy
  • Gorbunova Lab - Aging, DNA repair, and Cancer
  • Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
  • Land Lab - Cooperation of Oncogenic Mutations in the Control of Malignancy
  • Li Lab - Reproductive and RNA Biology
  • Maquat Lab - Normal & Disease-Associated RNA Decay
  • Mayer-Pröschel Lab - Impairment of Neural Cell Functions During Developmental Insults
  • Munger Lab - Mechanisms of Pathogenic Metabolic Manipulation
  • Smith Lab - Messenger RNA Expression & Processing
  • Steiner Lab - Understanding the molecular mechanisms underlying the development of red blood cells in both normal and disease states
  • Yu Lab - Functions & Mechanisms of RNA Modifications
  • Zhao Lab - Cell Proliferation and Mammalian Cells
  • Zhu Lab - Host-Virus Interactions, Particularly for HIV and Herpes Viruses

Protein Structure & Function

Protein Structure & FunctionStructure and function of proteins from primary to quaternary structures.

Active Research Laboratories

  • Hayes Lab - Chromatin Structure
  • Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
  • Maines Lab - Heme Oxygenase, Biliverdin Reductase & Cell Signaling
  • Maquat Lab - Normal & Disease-Associated RNA Decay
  • Benjamin Miller Lab - Molecular Recognition & Biosensing
  • Phizicky Lab - tRNA Biogenesis, Function & Quality Control
  • Smith Lab - Messenger RNA Expression & Processing
  • Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
  • Yu Lab - Functions & Mechanisms of RNA Modifications

RNA Structure & Processing

RNA Structure & ProcessingGeneration of a mature mRNA (for protein genes) or a functional tRNA or rRNA from the primary transcript.

Active Research Laboratories

  • Butler Lab - Regulation of Gene Expression by Targeted Degradation of RNA
  • Ermolenko Lab - Structural Dynamics of Translation
  • Grayhack Lab - The Roles of the Genetic Code in Translation
  • Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
  • Li Lab - Reproductive and RNA Biology
  • Maquat Lab - Normal & Disease-Associated RNA Decay
  • Mathews Lab - Computational Biology and Bioinformatics
  • Benjamin Miller Lab - Molecular Recognition & Biosensing
  • Phizicky Lab - tRNA Biogenesis, Function & Quality Control
  • Smith Lab - Messenger RNA Expression & Processing
  • Turner Lab - Forces Directing Nucleic Acid Chemistry, with Particular Emphasis on RNA Folding
  • Wedekind Lab - Development of New HIV/AIDS Drugs, Antibiotics, & RNA-based Therapeutics
  • Yu Lab - Functions & Mechanisms of RNA Modifications

Signal Transduction

Signal TransductionProcesses by which an extracellular signaling molecule activates a membrane receptor that in turn alters intracellular molecules creating a response.

Active Research Laboratories

  • Bohmann Lab - JNK, Fos, Foxo and Nrf2 Dependent Signaling and Gene Regulation in Oxidative Stress Response and Aging
  • Dickerson Lab - CGRP Signal Transduction
  • Dumont Lab - Signal Transduction; Membrane Protein Structure, Yeast Molecular Biology
  • Grossfield Lab - Computer Modeling to Understand Structure and Thermodynamics of Biological Molecules
  • Kielkopf Lab - Pre-mRNA Splicing for Treatment of Human Disease
  • Land Lab - Cooperation of Oncogenic Mutations in the Control of Malignancy
  • Maines Lab - Heme Oxygenase, Biliverdin Reductase & Cell Signaling
  • Munger Lab - Mechanisms of Pathogenic Metabolic Manipulation
  • Zhao Lab - Cell Proliferation and Mammalian Cells
  • Zhu Lab - Host-Virus Interactions, Particularly for HIV and Herpes Viruses