Lynne Maquat Interviewed at the RNA Symposium at Cold Spring Harbor Laboratory
Monday, June 17, 2019
Harold Smith Featured on Roc NORML Radio
Wednesday, May 22, 2019
So what exactly happens inside your body when you consume Cannabis? Dr. Smith outlines the powerful role of the Endocannabinoid System in modulating human health, and discusses the future of Cannabis research and testing.
Read More: Harold Smith Featured on Roc NORML Radio
Congratulations Dalia Ghoneim for winning a Born Seekers Fellowship
Wednesday, May 8, 2019
The Born Seekers fellowship is a speech contest that is open to women in STEM. The work they do pushes boundaries and meaningfully impacts society on a local, national, and often global level. The women selected as our 2019 Born Seekers build skills in communication and leadership, serving as role models for the next generation of scientists, engineers, doctors, and STEM professionals.
Dalia Ghoneim is a PhD candidate in Genetics at the University of Rochester in Rochester, NY. She develops and contributes to software that helps us understand the structure and functions of genetic molecules, and has worked to analyze mutations in DNA from patients with severe neurological diseases like epilepsy and autism. This work was instrumental to identifying new genes that cause these diseases. Dalia takes as many opportunities as she can to share science with others by participating in outreach and advocating for inclusion in science. Outside of science, Dalia is a single mother to four wonderful children, a competitive runner, and enjoys figure drawing and learning and experiencing new things.
31st Annual Genetics Day Symposium
Monday, April 22, 2019
The Departments of Biomedical Genetics and Biology, with the support of the University Committee for Interdisciplinary Studies, host the 31st annual Genetics Day Symposium on Thursday, April 25, from 9:30 a.m. to 4 p.m. in the Class of ’62 Auditorium and Flaum Atrium. This year’s Fred Sherman Lecturer will be Phillip Zamore, a Howard Hughes Medical Institute investigator and professor of biomedical sciences at the University of Massachusetts Medical School, giving a talk titled “piRNAs and the Struggle to Reproduce.”Read More: 31st Annual Genetics Day Symposium
Byron Rubin, Ph.D., Adjunct Professor in the Department of Biochemistry and Biophysics, pens article in ASBMB TODAY
Monday, February 18, 2019
Dr. Rubin describes his own battle with prostate cancer, and how as a scientist how he took control of his own treatment. He also describes the impact of personalized medicine on his medical decisions and how he deals with living with cancer. Read the article.
Former Biochemistry Student Jerry Madukwe, Ph.D. travels to West Africa to Speak With Students
Wednesday, January 30, 2019
Jerry Madukwe, Ph.D., who received his Ph.D. in Biochemistry (2018), and is currently a postdoctoral fellow at Yale University, recently completed a 2-week science-outreach trip to West Africa. Jerry was invited by the West Africa Center for Cell Biology of Infectious Pathogens at the University of Ghana, and the Department of Life sciences at the University of Ilorin in central Nigeria to talk about the work he did as a PhD student and about graduate school in the United States. Jerry, who hails from Nigeria, and got his BS from Lee University in Tennessee, also used the opportunity to visit his former elementary school where he talked to fifth grade pupils about science (see photos), and to demonstrate DNA extraction from bananas. The kids were very excited by his visit, and Jerry found the experience very fulfilling.
Chavali, Couch, DeZoysa and Hao Win Sayeeda Zain Travel Award
Tuesday, December 18, 2018
The department is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Shashank Chavali, Tyler Couch, Meemanage Dudarshika DeZoysa and Fanfan Hao.
The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience. The next round of Sayeeda Zain Travel Awards will be offered in Spring 2019.
Thank you to all those who applied and congratulations to Shashank, Tyler, Dudarshika and Fanfan!
Professor Harold Smith, Ph.D. appears on Evan Dawson Radio Program
Thursday, November 29, 2018
Harold C. Smith was a guest along with Bob Duffy (CEO of the Greater Rochester Chamber of Commerce), Jason Klimek (attorney with Boylan Code), Zachary Sarkis (co-founder of Flower City Solutions) and Jacob Fox (founder of Closed Loop Systems) on WXXI Connections with Evan Dawson on 11/21/2018 to address the opportunities and questions surround the emerging hemp industry in Up State NY. (listen to Hemp101http://www.wxxinews.org/programs/connections?page=1&ajax=1)
Dr. Smith spoke regarding the future of labeling and dosing of THC-free and THC-containing products relative to what we understanding from scientific and clinical research. Having founded CannaMetrix, LLC, a New York based company, Dr. Smith seeks to establish through patent pending, cell-based assays, to raise the standards for product development and quality control so as to better information patient choices of products containing full spectrum plant cannabinoids or synthetic cannabinoids and advance medicinal use of cannabis.
Wedekind Co-Organizes Nucleic Acids Session at American Crystallographic Association Annual Meeting in Toronto
Friday, November 9, 2018
Highlights of Session 1.1.2 on Nucleic Acid were reported in ACA RefleXions Fall 2018 and provided many new insights into the form and function of nucleic acids and was co-organized by Dr. Joseph Wedekind and Dr. Rui Zhao. Dr. Wen Zhang of Harvard University presented mechanistic studies of non-enzymatic RNA polymerization using custom phosphoramidites with imidazole leaving groups that were caught in the act of catalysis by crystallographic snapshots. This work has implications for catalysis in a pre-biotic RNA world. Sun Cheol Park from Kangwon National University, Korea described DNA recognition by the PadR repressor. Binding of phenolic acid blocks DNA binding to relieve PadR repression, activating downstream detoxification genes. Dr. Yun-Xing Wang from NIH/NCI described use of an X-ray free electron laser to capture conformational changes of the adenine riboswitch during effector binding, providing insights into RNA-mediated translational regulation.
Prof. Clara Kielkopf from the University of Rochester described progress to decode the basis of 3´-splice site recognition of pre-mRNA by U2AF proteins, including polypyrimidine tract recognition and binding to degenerate splice-sites. The work has implications for correction of splicing defects found in human diseases. Dr. Eric Montemayor from the University of Wisconsin described later steps of pre-mRNA splicing, including a model for U6 snRNA remodeling by contacts to the Lsm2-8 ring protein and the Prp24 chaperone. Dr. Soumya Remesh from the Lawrence Berkeley National Lab used small angle scattering and soft X-ray tomography to reveal how small molecules interact with the abundant HU protein to alter DNA supercoiling. The work has implications for controlling bacterial gene expression. The session was anchored by Dr. Ailong Ke of Cornell University who presented structural snapshots that contribute a novel mechanistic framework to describe how bacterial type II-A CRISPR systems create new molecular memories of short, foreign ‘spacer’ DNAs that invade bacterial cells.
Dumont Receives 2018 Outstanding Graduate Student Teacher Award
Tuesday, November 6, 2018
Biochemistry professor Mark Dumont, Ph.D. is the recipient of the 2018 Outstanding Graduate Student Teacher Award. Established in 2013, this award is given to an outstanding graduate student teacher for record of excellence in classroom instruction. Mark was nominated by graduate students Brandon Davis, Ashwin Kumar and Matthew Raymonda.
This award was presented at the School of Medicine and Dentistry Convocation Ceremony, September 6, 2018.
The department would like to extend congratulations to Mark on this well- deserved honor.
Kielkopf Lab Wins Annual Halloween Door Contest
Thursday, November 1, 2018
The department would like to thank all that participated in the BCBP Halloween Door Contest this year!
This year the winner is…
The Kielkopf Lab!!
Tied for second place are the Ermolenko Lab and the Grossfield Lab! Congratulations to everyone – the doors looked awesome!
Maquat Inducted into National Academy of Medicine
Sunday, October 21, 2018
Lynne Maquat, PhD, was inducted into the National Academy of Medicine (NAM) on Saturday October 13th in Washington, DC. Here, she is receiving her diploma and congratulations from Victor Dzau, MD, President of NAM after being introduced by J. Michael McGinnis, MD, the Executive Officer of NAM.
Clara L. Kielkopf, Ph.D. Receives Drug Development Grant From UR Ventures For Research To Cure Myelodysplastic Syndromes
Thursday, October 18, 2018
Myelodysplastic Syndromes (MDS) are a group of diverse bone marrow disorders, in which the bone marrow does not produce enough healthy blood cells. MDS is often referred to as a “bone marrow failure disorder.”
Congratulations, Clara and her lab!
Department of Biochemistry and Biophysics Loans Famous Statue to University of Rochester’s Laboratory of Laser Energetics
Wednesday, October 17, 2018
The Department of Biochemistry and Biophysics has loaned a statue of J. Robert Oppenheimer and Albert Einstein to the Laboratory of Laser Energetics. The sculpture was commissioned by the Department of Radiation Biology and Biophysics (William Neuman and Aser Rothstein co-chairs) in October of 1968 and was crafted by Achille Forgione, a notable Rochester artist. The work was in place by the fall of 1970, originally at the entrance to the OO wing, then moved to the Blair Library (no longer in existence). The statue has been in the back of the Neuman Room for many years. It is now displayed prominently in the LLE lobby. An engraved plate will be placed next to the statue, reading: "Albert Einstein, J. Robert Oppenheimer, Statue commissioned by Dr. William "Bill” Newman, On loan from the University of Rochester’s Department of Biochemistry and Biophysics"
For more information on Dr. Neuman and his work please visit our department featured alumni page.
Wedekind Lab Co-Crystal Structure of HIV RNA in complex with a Lab-Evolved Protein on the Cover of Nucleic Acids Research
Tuesday, July 31, 2018
Co-crystal structure of HIV trans-activation response (TAR) RNA (rainbow ribbon) in complex with lab-evolved protein, TBP6.7 (blue Cα ribbon). A short peptide (pink) binds TAR outside the context of TBP6.7. (art by Joseph Wedekind). The underlying electron micrograph shows HIV virions (CDC image #13472 by Maureen Metcalfe and Tom Hodge).
Nucleic Acids Research Breakthrough article describes structure of HIV TAR complex with engineered binding protein and structure-based synthesis of antagonist
Investigators at multiple research institutes, led by Dr. Joseph Wedekind (University of Rochester) have described the high resolution crystal structure of a laboratory-evolved protein bound to its tightly associated HIV TAR RNA target, and subsequent synthesis and characterization of a stapled peptide mimic of the predominant RNA binding epitope in that protein. The study provided a detailed framework for peptide-mediated TAR recognition that might be generally applicable to target other disease-relevant RNAs.
HIV/AIDS is a global health threat that requires new insights into viral targets, especially those that resist mutation and promote novel aspects of the viral life cycle. In these respects, the HIV-1 trans-activation response (TAR) RNA is of ongoing interest. Previously, investigators (including some from this author group) developed methods to produce a unique lab-evolved protein (‘TBP6.7’) that recognizes TAR with extraordinarily high affinity compared to known TAR binders [Crawford et al. McNaughton (2016) ACS Chem. Biol. 8, 2206]. However, the molecular determinants of TAR recognition remained obscure, thus limiting the investigators’ ability to further exploit that discovery. The crystal structure of this complex allowed investigators to determine that only a subset of the ‘evolved’ protein sequences are actually involved in RNA binding, with the preponderance of interactions localized to a short β-hairpin. This observation led them to synthesize a short, stapled peptide that mimics the β-hairpin and attenuates TAR-dependent transcription in HeLa nuclear lysate.
The study reported here [Belashov et al. Wedekind (2018) Nucleic Acids Res. 46, 6401-6415] is highly multi-disciplinary, spanning crystallography, site-directed mutagenesis, calorimetry, cell-surface display, ELISA, transcription assays, molecular dynamics simulations, and constrained peptide synthesis. In the end, the conversion of the parental RNA binding protein from single- to double-stranded RNA recognition implies that the protein has sufficient plasticity to recognize numerous RNA folds.
Reviewers and editors familiar with the work have stated that the study is “a strong contribution to a difficult field” that “will have substantial impact in the field of RNA recognition, ranging from applied (specifically targeting therapeutically relevant RNAs) to basic (understanding how RRMs bind to specific RNAs in the cell)”
The Wedekind laboratory at the University of Rochester investigates the mechanisms of action of non-protein-coding (nc)RNAs, and is interested especially in the three-dimensional architectures of these RNAs and how they bind to specific small molecules or peptides, leading to conformations that alter biological function. The research was supported by the University of Rochester Center for AIDS Research, and the National Institutes of Health.
Biochemistry & Biophysics Students Going Places
Tuesday, June 12, 2018
By Dr. Joseph Wedekind
The Department of Biochemistry & Biophysics is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Debapratim Dutta, Sierra Fox and Hong Zhu.
The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience.
Debapratim (Dave) Dutta is presenting a poster and was invited to give a talk at the Annual RNA Society Meeting (Berkeley, CA). Sierra Fox presented a poster and was a Keystone Symposia Future of Science Fund Scholarship recipient at the Keystone Symposia in Chromatin Architecture and Chromatin Organization, and Gene Control in Development and Disease Symposia (Whistler, BC, Canada). Hong Zhu presented a poster at the III International Conference on Vaccines Research and Development (Washington, DC).
Debapratim (Dave) Dutta
Congratulations to the 2018 Biochemistry Graduates!
Tuesday, May 22, 2018
Pictured are Anne Cheng, Venice Magunga, and Anmol Almast following the Arts, Sciences & Engineering commencement ceremony Sunday. Photo reproduced from 5-21-18 issue of @Rochester
The Department of Biochemistry and Biophysics congratulates the 20 young men and women who received their B.S. in Biochemistry this weekend. We look forward to their continued success in their future training and careers! In addition to the University-wide celebration, these graduates received their diplomas at a ceremony in The Class of ’62 Auditorium, attended by their families, friends, and faculty from the many departments involved in their training. The ceremony was officiated by Beth Grayhack, Ph.D., Director of the Undergraduate Program (Biochemistry and Biophysics), and was enriched by addresses from Sina Ghaemmaghami, Ph.D. (Biology) and Mark Dumont (Biochemistry and Biophysics).
Biochemistry and Biophysics Holds Annual Department Awards Ceremony
Sunday, May 20, 2018
On Friday May, 18th the department held it's annual awards ceremony in the Neuman Room. At the event this year the following awards were awarded to our current B&B graduate students:
- Bloor Award - Christina Brule and Lu Han
- Metzger Award - Karl J. P. Smith
- Sherman Award – Bronwyn Lucas
- Neuman Award – Chapin Cavender
- Grossfield Award – Sreyoshi Sur (talk), Lauren Benoodt (poster)
- Student Seminar Award – Fall: Bronwyn Lucas (BMB), Leslie Salas-Estrada (BSCB)
Spring: Viktoriya Anokhina (BMB), Daniel Steiner (BSCB)
- Hooker Award – Dudarshika DeZoysa (BMB), Christina Lai (BMB)
- Goodman Fellowship (3rd place for the Messersmith Award) – Leslie Salas-Estrada
- Faculty Award – Mark Dumont (BMB), Alan Grossfield (BSCB)
- Zain Award – Christine Lai, Lingfeng Luo, Louis Smith
Congratulations to all the winners and our 2018 graduates!
A Hidden Promise in the Language Cells Use to Communicate
Tuesday, May 8, 2018
Scientists have begun to implicate extracellular vesicles and exosomes in everything from cancer to viral infections to basic neural functioning. To Lynne Maquat, the J. Lowell Orbison Distinguished Service Alumni Professor in the Department of Biochemistry and Biophysics, the process shows how parts of the genome we used to think of as junk actually have important functions. “You could say that the host domesticated a viral sequence for its own purposes,” Maquat says. “That’s the beauty of our complexity—[these elements] allow tinkering or fine-tuning of genes.”Read More: A Hidden Promise in the Language Cells Use to Communicate
Looking to RNA for Answers
Friday, March 23, 2018
Cancer is a group of diseases in which the body’s cells divide uncontrollably and invade nearby tissues. Scientists at Wilmot Cancer Institute and the University of Rochester’s Center for RNA Biology are working to understand more about how and why this happens.
One piece of the puzzle they’re studying is ribonucleic acid, or RNA, which is found in all cells. RNA is made in the nucleus of a cell from our DNA, which holds the instruction manual for life. RNA puts those instructions into action.
RNA comes in many forms. One form, called messenger RNA (mRNA), carries those instructions out of the nucleus to the ribosomes, where proteins are made. These proteins are essential for functions ranging from digestion to protecting us from disease. If the mRNA has a bad copy of instructions, then either a faulty protein or no protein is created, leading to diseases like cancer.
Understanding the quality-control system
Lynne E. Maquat, Ph.D., director of the Center for RNA Biology, studies a quality control process that blocks cells from making faulty proteins. Called nonsense-mediated mRNA decay (NMD), this process comes into play when mRNA has a set of instructions with a mistake that will lead to short or incomplete proteins. NMD acts like a set of factory inspectors that find and destroy this mRNA before the faulty proteins can be made.
Sometimes, though, NMD doesn’t catch the mistakes and harmful proteins are made. This process plays a part in one-third of all inherited diseases, such as cystic fibrosis and muscular dystrophy, and one-third of all acquired diseases, including a number of cancers.
One reason is that tumors can influence how these inspectors work. Maquat and her team are looking for ways to stop tumors from interfering with NMD with the goal of finding new ways to treat cancer.
Slowing cancer’s growth
A team from Maquat’s lab has also identified a protein called Tudor-SN that is important as cells prepare to divide. This protein controls many microRNAs, molecules that are very small RNAs that control the expression of tens of thousands of genes.
The scientists found that when Tudor-SN is removed from human cells, levels of hundreds of microRNAs go up, putting the brakes on genes that encourage cell growth. This slows down the process of cell division known as the cell cycle, which goes awry in cancer.
Maquat and Reyad A. Elbarbary, Ph.D., a former post-doctoral fellow in Maquat’s lab, have filed a patent application for methods that target Tudor-SN for the treatment and prevention of cancer. They continue to study how Tudor-SN works in concert with other molecules and proteins so that scientists can identify the most appropriate drugs to target it.
Scientists at the Center for RNA Biology are also looking at RNA’s other roles in cancer to find new treatment strategies. For example, Mitchell O’Connell, Ph.D., is studying how microRNAs can interfere with the way genes are expressed and lead to cancer. He and his team are using the gene-editing technology known as CRISPR, which he has adapted to edit RNA, to learn more about the proteins involved in this process.
Yi-Tao Yu, Ph.D., and his team are studying various ways to modify mRNA so that it can override mistakes in genetic instructions. Sometimes there’s a premature stop signal that orders a cell to stop reading the genetic instructions in mRNA partway through the process, resulting in an incomplete protein. The Yu lab is working to alter mRNA in ways that turn “stop” signals into “go” signals, creating full length proteins and preventing diseases like cancer.
The study of RNA biology is allowing scientists and physicians to explore entirely new treatment strategies for cancer and a wide range of other genetic and acquired disorders.
Learn more about the work being done at the Center for RNA Biology.
By Lydia FernandezRead More: Looking to RNA for Answers
Maquat Wins 17th Annual Wiley Prize in Biomedical Sciences
Tuesday, February 20, 2018
The Wiley Foundation today announced the 17th annual Wiley Prize in Biomedical Sciences will be awarded to Lynne E. Maquat for elucidating the mechanism of nonsense-mediated messenger RNA decay, a fundamental process whereby cells remove defective transcripts that can encode toxic proteins.
Dr. Maquat is a Professor at the Department of Biochemistry & Biophysics in the School of Medicine and Dentistry, the Founding Director of the Center for RNA Biology: From Genome to Therapeutics, the Founding Chair of the University of Rochester Graduate Women in Science, and the J. Lowell Orbison Endowed Chair at the University of Rochester in Rochester, New York.
“The 2018 Wiley Prize honors Dr. Maquat, whose work illuminated how our cells prevent production of toxic proteins by removing defective messenger RNAs," said Dr. Titia de Lange, chairperson of the awards jury for the Wiley Prize at the Rockefeller University in New York City.
“The Wiley Foundation honors research that champions novel approaches and challenges accepted thinking in the biomedical sciences. The work of the 2018 Wiley Prize recipient Lynne Maquat truly upholds this mission,” said Deborah Wiley, Chair of the Wiley Foundation. “We are pleased to highlight the impact that her research on messenger RNA decay pathways has had in advancing our knowledge of the cellular cause of many human diseases.”Read More: Maquat Wins 17th Annual Wiley Prize in Biomedical Sciences
New Issue of Opportunities to Explore - February 12-16, 2018
Friday, February 9, 2018
This week there is a workshop on Navigating a career fair/expo, the PDA monthly meeting, a career expo on river campus and workshops from Future Faculty, CIRTL and GWIS. The week ends with a PONS luncheon and a Thinkers and Drinkers meeting
Looking further ahead, Stephen Tajc provides a look at his career in URBEST's series. Workshops on job descriptions and handling difficult conversations are available and CIRTL provides several events throughout the month. All this and more in the latest issue of OTE!
Latest Issue of Opportunities to Explore - February 12-16, 2018
Dutta, Fox, and Zhu Win Sayeeda Zain Travel Award
Tuesday, January 2, 2018
The department is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Debapratim Dutta, Sierra Fox and Hong Zhu.
The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience. The next round of Sayeeda Zain Travel Awards will be offered in Spring 2018.
Thank you to all those who applied and congratulations to Dave, Sierra and Hong!
Lynne Maquat Wins Vanderbilt Prize in Biomedical Science
Tuesday, November 28, 2017
Lynne E. Maquat, Ph.D., the J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry is the recipient of the 2017 Vanderbilt Prize in Biomedical Science. Established by Vanderbilt University School of Medicine in 2006, the competitive prize honors women scientists with a “stellar record” of research accomplishments who have made significant contributions to mentoring other women in science.
Maquat is internationally known for a huge body of research that describes what goes wrong in our cells during disease. The founding director of the University of Rochester’s Center for RNA Biology, she has spent her career deciphering the many roles that RNA plays in sickness and in health.
She’s dedicated a great deal of time to helping women advance in scientific careers and in 2003 established the University of Rochester Graduate Women in Science program. Through monthly round-table discussions with high-profile speakers who are using advanced degrees in traditional and non-traditional ways, the program seeks to broaden awareness of what women can do with a Ph.D. Program members can apply for travel awards to attend conferences, seminars or other external events that will help them advance their careers.
Maquat, also a professor in the Wilmot Cancer Institute, is the recipient of other prestigious honors, including the Canada Gairdner International Award; the International RNA Society’s Lifetime Achievement Awards in Service and in Science; the Federation of American Societies for Experimental Biology (FASEB) Excellence in Science Award; the Rochester ATHENA Award®; and election to the National Academy of Medicine, the National Academy of Sciences and the American Academy of Arts and Sciences.
Maquat is the 12th recipient of the Vanderbilt Prize in Biomedical Science and will receive the prize on November 29, 2018, when she is scheduled to give a Flexner Discovery Lecture. She will also meet with Vanderbilt faculty and mentor Vanderbilt Prize Scholars, women who are pursuing graduate studies in the biomedical sciences in the School of Medicine.
“We are thrilled that Dr. Maquat is being recognized for her pioneering work in RNA biology, which has catalyzed innovative areas of research and provided insight to the role of RNA regulation in human disease,” said Jennifer Pietenpol, Ph.D., Vanderbilt University Medical Center Executive Vice President for Research and director of the Vanderbilt-Ingram Cancer Center. “She is a world-renowned scientist and an exceptional mentor, a role model for us all.”Read More: Lynne Maquat Wins Vanderbilt Prize in Biomedical Science
New Issue of Opportunities to Explore – November 27-December 1, 2017
Tuesday, November 28, 2017
The latest issue of Opportunities to Explore is out!
Deadline for the Teaching-as-Research (TAR) Fellowship and is Friday, December 1, 2017.
Check out the CPD’s Lending Library catalog to see free professional development books and resources you can sign out and utilize. To borrow a book, stop by our office in G-9627 or email us with your request.
New Issue of Opportunities to Explore –
November 27-December 1, 2017
Lynne Maquat Delivers Harvey Society Lecture at Rockefeller University
Tuesday, November 7, 2017
Lynne E. Maquat, Ph.D., the J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics and Director of the Center for RNA Biology gave a Harvey Society Lecture on October 19 at The Rockefeller University in New York City. The lecture series is one of the most prestigious in the country and the lecturers, who are selected by the Harvey Society's leadership council, are leading biomedical researchers from around the world.
Maquat discussed her career path and the discovery of nonsense-mediated mRNA decay (NMD), which she first described for humans in 1981. NMD is a cellular quality control mechanism that derails the production of unwanted proteins in the body that can disrupt normal processes and initiate disease. Maquat is known around the world for her work on NMD, which is critically important in both normal and disease states. UR President Joel Seligman and URMC CEO and SMD Dean Mark Taubman attended the lecture.
Founded in 1905, the Harvey Society sponsors seven lectures annually that are open to the public and are attended by hundreds of scientists from New York City and the surrounding areas. The Harvey Lectures are one of the great traditions in New York science and they are a place where scientists from different institutions meet regularly.
New Issue of Opportunities to Explore - October 30-November 3, 2017
Tuesday, October 31, 2017
The latest issue of Opportunities to Explore is out!
Interested in learning more about employment within industry? Kurt Schilling, PhD will be here to share his career story and discuss what he does as senior vice-president of Basic Research and Advanced Technologies at The Estée Launders Companies, Inc.
Applications are now open for the Teaching-as-Research (TAR) Fellowship and will be accepted until Friday, December 1, 2017.
Opportunities to Explore - October 30th - November 3rd
New Issue of Opportunities to Explore
Monday, October 23, 2017
The latest issue of Opportunities to Explore is out!
This week there are many career related resources including a CV writing workshop and a job search support group
Later on this month there are events about negotiation, health insurance for postdocs, and online and virtual career fairs. All this and more can be found inside!
Opportunities to Explore - October 23rd - October 27th
New Issue of Opportunities to Explore - October 16-20, 2017
Monday, October 16, 2017
The Week of Undergraduate research day is here! But before you get to that always awesome event on Friday, make sure you check out the other events happening this week and fill up your calendar with all the other things we have planned, by taking a look at the latest issue of Opportunities to Explore!
Opportunities to Explore - October 16th - October 20th
URMC Scientist Lynne Maquat Elected to National Academy of Medicine
Monday, October 16, 2017
Lynne E. Maquat, Ph.D., an internationally recognized researcher who studies what happens in our cells during disease, has been elected to the National Academy of Medicine. The honor is akin to an actor receiving an Emmy for an outstanding performance; current members of the Academy elected Maquat for her exceptional research in the field of RNA biology. The accolade places her amongst an elite group of scientists and physicians who have made significant contributions to health and medicine.
In studying RNA, a close cousin to DNA, Maquat has discovered intricate cellular processes that influence normal genes, as well as genes involved in a wide range of diseases. Her findings are leading to the development of new treatment approaches for everything from cancer and heart disease, to intellectual and developmental disabilities and other neurologic disorders.
“Lynne is at the forefront of a movement to transform our increasing understanding of RNA biology into promising therapies for virtually all disease processes,” said Mark B. Taubman, M.D., CEO of the University of Rochester Medical Center and Dean of the University of Rochester School of Medicine and Dentistry. “She is an incredible asset to the University and will undoubtedly bring a wealth of valuable experience and knowledge to the National Academy of Medicine.”
Formerly called the Institute of Medicine, the National Academy of Medicine is an independent organization of professionals from diverse fields that advises the nation and the international community on issues in health, medicine and related policy. For example, in 2016 the Academy released a report calling for more and better research into ovarian cancer, one of the deadliest cancers, and recently issued a report detailing how physicians can help combat America’s opioid crisis.
The J. Lowell Orbison Endowed Chair and Professor of Biochemistry & Biophysics and of Oncology at the University of Rochester School of Medicine and Dentistry, Maquat is also an elected member of the National Academy of Sciences and the American Academy of Sciences. She was the first individual from upstate New York to receive the prestigious Canada International Gairdner Award, the country’s top award for excellence in biomedical research, which she won in 2015.
The National Institutes of Health has continuously funded Maquat’s research for the past 34 years and she’s published more than 150 papers and reviews. She is the founding director of the University of Rochester Center for RNA Biology and founding chair of the Graduate Women in Science program. She’s committed countless hours to mentoring the next generation of researchers and advocating for young women in the sciences.
When she is formally inducted into the National Academy of Medicine in October 2018, Maquat will join four other active Rochester faculty members: Seymour I. Schwartz in the Department of Surgery: Elizabeth R. McAnarney in Pediatrics; Paul S. Frame in Family Medicine; and Robert C. Griggs in Neurology.Read More: URMC Scientist Lynne Maquat Elected to National Academy of Medicine
New Issue of Opportunities to Explore - October 9-13, 2017
Friday, October 6, 2017
The latest Opportunities to Explore are available! Feel free to browse the numerous events we have coming up for Graduate Students and Postdocs...
October 9-13 Issue of Opportunities To Explore
New Issue of Opportunities to Explore - October 2-6, 2017
Friday, September 29, 2017
The latest Opportunities to Explore are available! Feel free to browse the numerous events we have coming up for Graduate Students and Postdocs...
October 2-6 Issue of Opportunities To Explore
Biochemistry & Biophysics students Mukta Palshikar, Erica VanderWal, and Brandon Davis receive awards at UR School of Medicine Opening Convocation
Friday, September 22, 2017
Congratulations to first year students who received awards at the SMD Opening Convocation on September 12, 2017.
Mutka Palshikar, a first year student in the Biophysics, Structural and Computational Biology program won the Graduate Alumni Fellowship, which recognizes an incoming student with promise for exceptional accomplishment in graduate study.
Arica VanderWal, a first year student in the Biochemistry and Molecular Biology program was awarded the Elmer Stotz Fellowship in Biochemistry, which recognizes the meritorious academic and research accomplishments of an incoming graduate student in the BMB program.
Brandon Davis, an incoming student in the Biochemistry and Molecular Biology program, was a recipient of a Robert L. and Mary L. Sproull University Fellowship, which recognizes the exceptional academic record and research talent of selected students in the first year class University-wide.
Congratulations again to Mutka, Arica, and Brandon!
New Issue of Opportunities to Explore - September 25-29, 2017
Friday, September 22, 2017
The newest issue of Opportunities to explore is out!
As we head into Fall, we have the following items in this issue(and these events are just THIS Week!)
- New UR BEST Career Story and Workshop
- New Career events on entrepreneurship and recruitment
- 7th Annual Bioethics lecture
...and so much more!
Read About The Latest Opportunities To Explore
The CARE Network
Friday, September 8, 2017
The CARE Network, a program that helps support students in distress, is now available for SMD graduate students. Students, faculty and staff are encouraged to submit a referral to the CARE Network if they believe that a student is in or headed towards distress, are aware of an act of discrimination on campus, or have a general concern for a student. The CARE Network provides recommendations to campus and community resources, outlets for safe spaces, and coaches on communication skills to work through difficult discussions and situations. You can submit a referral and/or learn more about the CARE Network at www.rochester.edu/CARE.Read More: The CARE Network
Dumont Selected as the 2017 Recipient of the Graduate Student Society Advocacy Award
Monday, August 28, 2017
Biochemistry professor Mark Dumont, Ph.D. has been selected as the 2017 recipient of the Graduate Student Society Advocacy Award. This award, established in 1994 by the Graduate Student Society (GSS), is bestowed annually to recognize a faculty member in the School of Medicine and Dentistry who has made significant contributions in promoting excellence in graduate education through participation, facilitation, and promotion of GSS goals and events. The faculty member may be nominated by any SMD student, and is chosen by a GSS Executive Board vote.
The award will be presented at the School of Medicine and Dentistry Convocation Ceremony on Tuesday, September 12th at 4:00pm in the Class of 1962 Auditorium.
The department would like to extend congratulations to Mark on this recognition, as it is a well-deserved honor.
Maquat Honored with FASEB Award, Featured on People Behind the Science Podcast
Friday, August 25, 2017
Dr. Lynne Maquat, J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics in the School of Medicine and Dentistry, Director of the Center for RNA Biology, and Chair of Graduate Women in Science at the University of Rochester was recently featured on the podcast, People Behind the Science.
Lynne discusses her mentors and career milestones, and offers advice to junior scientists. Maquat recently received the Federation of American Societies for Experimental Biology's Excellence in Science Award, which recognizes women who have made outstanding contributions to science through research discoveries and by training the next generation of scientists.
The entire interview can be listened to for free on iTunes.Read More: Maquat Honored with FASEB Award, Featured on People Behind the Science Podcast
Russ Hilf listed among life-long ASBMB Members
Thursday, August 17, 2017
Dr. Russell Hilf
Russel Hilf, Ph.D., Professor Emeritus in Biochemistry and Biophysics, was listed among American Society of Biochemistry and Molecular Biology members with at least 50 years of membership.
The ASBMB is a nonprofit scientific and educational organization with over 12,000 members, founded in 1906. The Society's mission is to advance the science of biochemistry and molecular biology and to promote the understanding of the molecular nature of life processes. Congratulations Russ!
Biochemistry Graduate Students Sierra Fox and Chris Goodwin Explain CRISPR Gene Editing on YouTube
Wednesday, August 16, 2017
From left: Sierra Fox and Christopher Goodwin
UR Science ROCs: What's CRISPR?
It’s no secret: URMC is home to extraordinary scientific innovations and research.
Our UR Broadening Experiences in Scientific Training (URBEST) program and our Public Relations and Communications office teamed up to offer our students and trainees the chance to highlight our research through original visuals and videos. Four videos earned prizes for their unique science storytelling and will be featured on our intranet site and the UR Medicine Facebook page throughout the month in an ongoing series called "UR Science ROCs."
What is CRISPR?
Fourth-year graduate students Chris Goodwin and Sierra Fox, and third-year graduate student Nick Nobiletti, talk about CRISPR and how it’s helping scientists edit DNA.
Goodwin is a student in the lab of Joshua Munger, Ph.D.(Department of Biochemistry and Biophysics); Fox is a student in the lab of Michael Bulger, Ph.D.(Departments of Biochemistry and Biophysics and Pediatrics); and Nobiletti is a student in the lab of Angela Glading, Ph.D. (Department of Pharmacology and Physiology).
Payea and Mishra are Inaugural Recipients of the Sayeeda Zain Travel Award
Friday, July 14, 2017
The department of Biochemistry and Biophysics recently presented to the inaugural Sayeeda Zain Travel Award to Mathew Payea and Laxmi Narayan Mishra.
Matthew Payea is a 6th year graduate student in the Biochemistry Ph.D. program studying tRNA biology in laboratory of Eric Phizicky. Matthew received his Bachelors in Science from Eastern Illinois University, majoring in Biochemistry. Matthew used the funding provided by the Sayeeda Zain Travel Award to attend the 22nd annual meeting of the RNA Society in Prague, Czech Republic this past June. There, he gave a talk on his research defining an RNA decay pathway in yeast that destroys mutant tRNAs.
Laxmi Narayan Mishra is a postdoctoral associate working in Dr. Jeffrey J Hayes’ Lab in the Department of Biochemistry and Biophysics, University of Rochester Medical Center. He has a Masters degree from University of North Bengal, Darjeeling, India and a Ph.D. in Biochemistry from Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India. His research is focused on how epigenetic modifications alter chromosome structure to facilitate gene expression. His Dr. Mishra will use the Sayeeda Zain Travel Award to attend and present his research findings at the international EMBO conference on “The Nucleosomes: From Atoms to Genomes” at Heidelberg, Germany, in August 2017.
The Sayeeda Zain Travel Award is given semi-annually to one or more graduate students and postdoctoral fellows in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry. The award honors the life and achievements of Professor Sayeed Zain, Ph.D., a longtime faculty member in the Department of Biochemistry and Biophysics. Learn more about the award and Dr. Zain.
Matthew Payea (left) with Dr. Jeffrey Hayes
Laxmi Narayan Mishra (left) with Dr. Jeffrey Hayes
Budding UR Scientists and Science Communicators
Thursday, July 13, 2017
Emily Boynton and Molly Miles from URMC’s Department of Public Relations and Communications met with a small group of URBEST trainees to discuss how the Medical Center and other academic institutions are sharing science in the social world we live in. They provided some examples of different types of visuals and videos that get great engagement on Facebook, Twitter and other social media sites. The goal? URBEST and The Public Relations and Communications team wanted to find and offer prizes for three original visuals or videos from students and trainees that highlight UR innovation and research. Money, video packs and fame!
First prize was awarded to a team of scientists: Chris Goodwin and Sierra Fox from Biochemistry and Molecular Biology and their camera man Nicholas Nobiletti from Pharmacology and Physiology for What Is CRISPR? They split $750 of prize money.Read More: Budding UR Scientists and Science Communicators
Jeffrey Hayes Helps Increase Our Understanding of DNA's Path Into Cells
Thursday, June 29, 2017
Scientists are a step closer to understanding how DNA, the molecules that carry all of our genetic information, is squeezed into every cell in the body. How DNA is “packaged” in cells influences the activity of our genes and our risk for disease. Elucidating this process will help researchers in all areas of health care, from cancer and heart disease, to muscular dystrophy and osteoarthritis.
DNA is a long, floppy molecule, and there’s more than three feet of it in every cell. Our DNA is housed in structures called chromosomes, which condense the DNA to fit into the cell’s tight quarters.
Scientists from the department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry worked with colleagues in France and Japan to describe the first step of DNA packing in a cell. They provided the first-ever detailed picture of the most basic building block of chromosomes, known as the nucleosome, and found that a protein known as H1 (for linker histone H1) helps DNA become more compact and rigid within the nucleosome. In contrast, when H1 isn’t present, the DNA is loose and flexible.
The tight structure that H1 creates helps shield our DNA from various factors that can activate or “turn on” certain genes. Without H1, DNA is more accessible to factors that could trigger disease-causing genes.
Published in the journal Molecular Cell, this finding will inform research on all processes that involve chromosomes, such as gene expression and DNA repair, which are critical to the understanding of diseases such as cancer, according to Jeffrey J. Hayes, Ph.D., senior study author and the Shohei Koide Professor and chair of the department of Biochemistry and Biophysics.
The teams in France and Japan used specialized microscopes and X-rays to capture pictures of DNA molecules interacting with H1 and other key proteins. Because of the size of the DNA and protein molecules, the pictures generated by these techniques were fuzzy and difficult to analyze.
Lead study author Amber Cutter, a graduate student in Hayes’ lab, put all of the components – DNA, H1, and other proteins – together in tiny test tubes and conducted various biochemical experiments. Her tests, coupled with the X-ray images, confirmed H1’s role.
Cutter (pictured at right), who is entering her fifth year in Hayes’ lab, admits that the science is complex and that a lot more research needs to be done before this work can inform clinical treatment. But, the importance of understanding the most basic biological processes should not be underestimated. “In order to determine what happens when things go wrong in diseases like cancer, we need to know what happens when things go right.”
Hayes and Cutters' work was supported by the National Institutes of Health.
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The University of Rochester Medical Center is home to approximately 3,000 individuals who conduct research on everything from cancer and heart disease to Parkinson’s, pandemic influenza and autism. Spread across many centers, institutes and labs, our scientists have developed therapies that have improved human health locally, in the region and across the globe. To learn more, visit www.urmc.rochester.edu/research.
Read More: Jeffrey Hayes Helps Increase Our Understanding of DNA's Path Into Cells
Study: A New Way to Slow Cancer Cell Growth
Friday, May 26, 2017
Cells grow and divide during the cell cycle
Cancer is an extremely complex disease, but its definition is quite simple: the abnormal and uncontrollable growth of cells. Researchers from the University of Rochester’s Center for RNA Biology have identified a new way to potentially slow the fast-growing cells that characterize all types of cancer. The findings, reported today in the journal Science and funded by the National Institutes of Health, were made in kidney and cervical cancer cells in the laboratory and are a long way from being applied in people. But, they could be the basis of a treatment option in the future, the authors said.
Cancer: The Cell Cycle Gone Wrong
All cells go through the “cell cycle,” a series of events that culminate in orderly cell growth and division. In cancer, the cell cycle is out of whack; cells divide without stopping and invade surrounding tissues.
Lynne Maquat, Ph.D.
Researchers identified a protein called Tudor-SN that is important in the “preparatory” phase of the cell cycle – the period when the cell gets ready to divide. When scientists eliminated this protein from cells, using the gene editing technology CRISPR-Cas9, cells took longer to gear up for division. The loss of Tudor-SN slowed the cell cycle.
“We know that Tudor-SN is more abundant in cancer cells than healthy cells, and our study suggests that targeting this protein could inhibit fast-growing cancer cells,” said Reyad A. Elbarbary, Ph.D., lead study author and research assistant professor in the Center for RNA Biology and the department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry.
Elbarbary, who works in the laboratory of senior study author Lynne E. Maquat, Ph.D., a world-renowned expert in RNA biology, adds that there are existing compounds that block Tudor-SN that could be good candidates for a possible therapy.
Putting the Brakes on Cell Growth
Maquat’s team discovered that Tudor-SN influences the cell cycle by controlling microRNAs, molecules that fine tune the expression of thousands of human genes.
When Tudor-SN is removed from human cells, the levels of dozens of microRNAs go up. Boosting the presence of microRNAs puts the brakes on genes that encourage cell growth. With these genes in the “off” position, the cell moves more slowly from the preparatory phase to the cell division phase.
“Because cancer cells have a faulty cell cycle, pursuing factors involved in the cell cycle is a promising avenue for cancer treatment,” noted Maquat, director of the Center for RNA Biology and the J. Lowell Orbison Endowed Chair and professor of Biochemistry and Biophysics.
Maquat, who also holds an appointment in the Wilmot Cancer Institute, and Elbarbary have filed a patent application for methods targeting Tudor-SN for the treatment and prevention of cancer. Research next steps include understanding how Tudor-SN works in concert with other molecules and proteins so that scientists can identify the most appropriate drugs to target it.
Keita Miyoshi, Ph.D., staff scientist in Maquat’s lab, served as lead study author with Elbarbary. Jason R. Myers and John M. Ashton, Ph.D. from the UR Genomics Research Center played an instrumental role in the study analysis.Read More: Study: A New Way to Slow Cancer Cell Growth
Using rooster testes to learn how the body fights viruses
Thursday, April 27, 2017
Researchers from the University of Rochester Center for RNA Biology: From Genome to Therapeutics examined the role of piRNA in safeguarding the integrity of the genetic information in germ cells. It's known that piRNA -- a type of ribonucleic acid (RNA) that's found most readily in the testes and ovaries -- shields germ cells by silencing the genetic sequences of viral intruders. It's also known that defects or mutations in piRNA lead to infertility in humans and other animals. What's not known is how piRNAs are generated in the first place.
A team led by Xin Li, Ph.D., assistant professor in the departments of Biochemistry and Biophysics and Urology at the University of Rochester School of Medicine and Dentistry, analyzed rooster testes to find out.Read More: Using rooster testes to learn how the body fights viruses
BMB, BSCB Students Win 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student
Saturday, April 1, 2017
BMB and BSCB graduate students, Lauren Benoodt, Tyler Couch, and Lisa Houston have been selected as joint winners of the 2017 Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student. The students will be presented with a certificate, as well as checks of $700 for each. The three of them were TA’s for IND 408 (Advanced Biochemistry) in the Fall of 2016.
The Edward Peck Curtis Award for Excellence in Teaching by a Graduate Student was established to recognize graduate students who advance the teaching mission of the University by providing highly skilled and innovative undergraduate instruction.
The strongest nominations show innovation in teaching and a positive impact on the learning of undergraduates.
Congratulations Lauren, Tyler, and Lisa!
Maquat Receives Lifetime Achievement Award in Science from International RNA Society
Tuesday, February 7, 2017
Lynne E. Maquat, Ph.D. has spent her career unraveling what happens in our cells during disease, making seminal contributions to our understanding of RNA’s role in sickness and in health. She’s also committed countless hours to mentoring the next generation of researchers and advocating for young women in the sciences. For these exceptional efforts, she’s receiving the 2017 Lifetime Achievement Award in Science from the international RNA Society.
The J. Lowell Orbison Endowed Chair and Professor in the Department of Biochemistry and Biophysics at the University of Rochester School of Medicine and Dentistry, Maquat began her professional career studying inherited anemias. She discovered a quality control process that blocks the creation of toxic proteins that cause disease. Known as nonsense-mediated mRNA decay or NMD, this process plays a part in one third of all inherited diseases, such as cystic fibrosis and muscular dystrophy, and one third of all acquired diseases, including a number of cancers.
“This award recognizes Lynne’s pioneering contributions to understanding the mechanisms of RNA, as well as her outstanding leadership, support and commitment to our field, including her role as a model for new generations of scientists,” said Juan Valcarcel Juarez, current president of the RNA Society, who works at the Centre for Genomic Regulation in Barcelona, Spain.
James McSwiggen, CEO of the RNA Society, added, “I can’t imagine a more appropriate choice of awardee.”Read More: Maquat Receives Lifetime Achievement Award in Science from International RNA Society