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Student Seminars

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NSC 503, NSC Student Seminar

Michael DuHain - Neuroscience Ph.D. Candidate

The Role of Beta-2 Adrenergic Receptor on Cortical and Cerebellar Microglia

 Dec 16, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Investigating Glatiramer Acetate’s Mechanism of Action in the 5xFAD Alzheimer’s Disease Model

Berke Karaahmet
Advisor: Kerry O’Banion, Ph.D.
- Ph,D, Thesis Proposal

Alzheimer’s disease (AD) is the most common form of dementia and its prevalence is expected to rise. The most striking molecular pathology in AD is the extracellular protein aggregates, termed amyloid plaques. It is established that peripheral immunomodulatory interventions can alter this histopathological hallmark and are associated with improved outcomes. Our lab has previously observed that the relapsing remitting Multiple Sclerosis (MS) drug Glatiramer Acetate (GA, Copaxone®) can improve amyloid and tau pathology, and ameliorate cognitive impairments in the 3xTg AD mouse model. Although our group and others have shown that GA treatment decreases amyloid pathology across a variety of models, the exact mechanism of this elusive drug, even in its principle applications, remains unclear. Similar to the findings from literature concerning animal models of MS, we hypothesize that GA modulates both CD4+ T cell and monocyte function towards a phenotype more conducive to tissue repair and homeostasis, and both these cell types have potential to mediate protection from amyloid pathology.
In Aim 1, we will investigate the necessity and sufficiency of CD4+ T cells in GA’s mechanism of action through antibody-mediated depletion studies under GA treatment and adoptive transfers of CD4+ T cells from GA vaccinated donors into 5xFAD hosts which develop amyloid pathology much faster than other common AD models. In addition, we will test whether a Th2 transcriptional profile and migration into the brain parenchyma, the two components of “bystander suppression” hypothesis, are required for GA’s mechanism in AD. In Aim 2, we will investigate whether monocytes are sufficient and necessary in GA’s mechanism of action by adoptive transfer of monocytes isolated from GA treated mice and liposome mediated depletion studies. Furthermore, we will confirm that GA modulates the expression of several key transcripts in monocyte phenotype and also attempt to understand the crosstalk between monocytes and CD4+ T cells in development of a response to GA by adoptively transferring monocytes from GA treated Rag2-/- donors. Altogether, this project will identify key, easily accessible peripheral immune players in GA’s mechanism. Greater understanding in this domain will help repurpose a drug with an excellent safety profile to a new context and give insights into the impact of peripheral immune cell types in AD.

 Dec 11, 2019 @ 10:45 a.m.

 Medical Center | 3-7619 Upper Auditorium

NSC 503, NSC Student Seminar

Linh Le & Caitlin Sharp - Neuroscience Ph.D. Candidates

Neuritogenic effect of Troglitazone on corneal nerves - Le
Examining auditory processing through priors for musical rhythms - Sharp

 Dec 09, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Human herpesvirus 6A latency gene U94A impairs motility and maturation in glial cells and neurons: Implications for neurodegenerative disease

Jessie Hogestyn
Advisor: Dr. Margot Mayer-Pröschel
- Ph.D. Thesis Defense

Many neurodegenerative diseases have a multifactorial etiology and variable course of progression that cannot be explained by current models. Neurotropic viruses have long been suggested to play a role in these diseases, although their exact contributions remain unclear. Human herpesvirus 6A (HHV-6A) is one of the most common viruses detected in the adult brain, and has been clinically associated with multiple sclerosis (MS), and, more recently, Alzheimer’s disease (AD). HHV-6A is a ubiquitous viral pathogen capable of infecting glia and neurons. Primary infection in childhood is followed by the induction of latency, characterized by expression of the U94A viral transcript in the absence of viral replication. Our work is the first to examine the effects of this common viral gene on cells of the central nervous system. We found that U94A expression inhibits the migration and maturation of human oligodendrocyte precursor cells (OPCs) without affecting their viability, a phenotype that may contribute to the failure of remyelination seen in many patients with MS. Large-scale transcriptomics and proteomics analyses indicate that U94A expression in OPCs alters the expression of genes involved in cytoskeletal regulation and in cellular interactions with the extracellular matrix, while preliminary biochemical analyses suggest that U94A may exert its functions by interacting with nucleosomes and with myosin motors. As HHV-6A seems to be significantly associated with early AD pathology, we extended our initial analysis of U94A in OPCs to cytoskeletal abnormalities in neurons. We found that U94A expression inhibits morphological maturation in human cortical neurons. Given that morphological abnormalities are known to precede synapse loss and cognitive impairment in AD patients, we hypothesize that U94A expression in neurons renders them more susceptible to dysfunction and degeneration. Our work suggests that the persistent presence of HHV-6A-associated proteins establishes a state of vulnerability that can contribute to disease progression in MS and AD. We propose this virus as a unique human factor to consider in the translation of therapies from animal models to human patients.

 Dec 09, 2019 @ 1:00 p.m.

 Medical Center | G-9425 Class of '62 Auditorium

NSC 503, NSC Student Seminar

Sarah Yablonski & Johanna Frtizinger - Neuroscience Ph.D. Candidates

Validating Otoacoustic Emission Cochlear Tuning Curves in Budgerigars - Fritzinger
Sufficiency of CA-ERBB2 Signaling in Cochlear Regeneration - Yablonski

 Dec 02, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Matthew Adusei & MaKenna Cealie - Neuroscience Ph.D. Candidates

Analyzing the Impact of Spatial Attention Manipulation in Cortically Blind Patients - Adusei
Mapping Neuronal Populations Engaged in Cannabidiol-induced Analgesia - Cealie

 Nov 25, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Kamy Wakim-Takiki & Neal Shah - Neuroscience Ph.D. Candidates

Putting on the Brakes: the Neurobiology of Inhibitory Control in HIV+ Individuals with a History of Substance Dependence - Wakim
Upstream pathway analysis of c-Cbl inhibition in glioblastoma multiforme - Shah

 Nov 18, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Emily Warner & Yunpeng Pang - Neuroscience Ph.D. Candidates

The role of feedback from ventral CA1 to the main olfactory bulb in sensory processing – Warner
Oxidation signaling drives oligodendrocyte progenitor differentiation via the Redox-Fyn-c-Cbl (RFC) pathway – Pang

 Nov 11, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Neuroscience Thanksgiving Potluck

Sign up here by November 6th

 Nov 11, 2019 @ 1:00 p.m.

 Helen Wood Hall | Evarts Lounge

NSC 503, NSC Student Seminar

Kathleen Miller-Rhodes & Ally McHale - Neuroscience Ph.D. Candidates

Lung-brain coupling following ischemic stroke -- Miller-Rhodes
Inclusion of dlPFC and vlPFC inputs in cortico-amygdala topography -- McHale

 Nov 04, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Garrick Salois - Neuroscience Ph.D. Candidates

 Oct 14, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Holly Beaulac - Neuroscience Ph.D. Candidates

 Oct 07, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Functional Micro-Architecture and Joint Representation of Shape and Color in Primate Primary Visual Cortex

Edward Callaway, PhD
Vincent J. Coates Chair and Professor
- Systems Neurobiology Labs
The Salk Institute for Biological Studies

Refreshments before the lectures starting at 3:20 pm

 Oct 03, 2019 @ 4:00 p.m.

 Kornberg Medical Research Building | K307 Auditorium

Host: Department of Neuroscience and the Del Monte Institute for Neuroscience

NSC 503, NSC Student Seminar

Humberto Mestre - Neuroscience Ph.D. Candidates

 Sep 30, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Erik Musiek - Neuroscience Visiting Speaker

 Sep 23, 2019 @ 4:00 p.m.

 Medical Center | K-207 (2-6408)

An Amygdala to Ventrolateral Prefrontal Cortex Projection Implicated in Emotional Recognition - PhD Thesis Proposal

Keshov Sharma - PhD Candidate
Advisors: Lizabeth Romanski and Julie Fudge

 Sep 19, 2019 @ 1:00 p.m.

Host: Neuroscience Graduate Program

NSC 503, NSC Student Seminar

Monique Mendes - Neuroscience Ph.D. Candidates

 Sep 16, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Functional Brain Network Structure in Focal Embouchure Dystonia and Related Disorders

Aimee Morris - PhD Candidate - Neuroscience, Advisor: Dr. Jon Mink & Dr. Joel Perlmutter

 Jul 01, 2019 @ 2:00 p.m.

 Medical Center | 1-7619 Adolph Lower Auditorium

Functional Brain Network Structure in Focal Embouchure Dystonia and Related Disorders

Aimee Morris - Neuroscience PhD Candidate

 Jul 01, 2019 @ 2:00 p.m.

 Medical Center | Lower Adolph Auditorium 1-7619

Host: Dr. Jonathan Mink

Noradrenergic modulation of microglial dynamics and synaptic plasticity

Rianne Stowell - PhD Candidate - Neuroscience, Advisor: Ania Majewska

 Jun 28, 2019 @ 1:00 p.m.

 Medical Center | 3-6408 K-307 Auditorium

Noradrenergic modulation of microglial dynamics and synaptic plasticity

Rianne Stowell - Neuroscience PhD Candidate

 Jun 28, 2019 @ 1:00 p.m.

 Medical Center | Auditorium K-307

Host: Dr. Ania Majewska

Ameliorating Alzheimer’s Disease tau pathology through immunomodulation: A novel role for interleukin 4 and glatiramer acetate

Dawling Dionisio-Santos - PhD Candidate - Neurobiology & Anatomy, Advisors: Kerry O'Banion and John Olschowka

 Jun 26, 2019 @ 1:00 p.m.

 Medical Center | 3-7619 Upper Auditorium

Ameliorating Alzheimer’s Disease tau pathology through immunomodulation: A novel role for interleukin 4 and glatiramer acetate

Dawling Dionisio-Santos - Neurobiology and Anatomy PhD Candidate

 Jun 26, 2019 @ 1:00 p.m.

 Medical Center | Upper Auditorium 3-7619

Host: Dr. Kerry OBanion

NSC 503, NSC Student Seminar

Luke Shaw & Cody McKee - Ph.D. Candidates

 May 06, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC Thesis Proposal: Investigating changes in population coding in the APP/PS1 mouse model of Alzheimer’s disease

Uday Chockanathan - Ph.D. Candidate - Advisor: Krishnan Padmanabhan

 May 01, 2019 @ 11:00 a.m.

 Medical Center | 2-6424 Whipple Auditorium

NSC 503, NSC Student Seminar

Greg Reilly, Jake Rudlong & Mark Stoessel - Ph.D. Candidates

 Apr 29, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar: Guest Speaker

Jeffrey Macklis, MD - Harvard Department of Stem Cell and Regenerative Biology

 Apr 22, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Alesha Foster, Silei Zhu & Fei Shang - Ph.D. Candidates

 Apr 15, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Jingyi Yang, Dennis Jung & Kathryn Toffolo - Ph.D. Candidates

 Apr 08, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar: Guest Speaker

Staci Bilbo, PhD - Director of Research, Lurie Center for Autism
Harvard University Program in Neuroscience

 Apr 01, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Allison Murphy & Sam Abbott - Ph.D. Candidates

 Mar 25, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Berke Karaahmet & Laura Owlett - Ph.D. Candidates

 Mar 18, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Stability and Change in Human Functional Brain Networks

Steven Petersen, Ph.D. - The James S. McDonnell Professor of Cognitive Neuroscience in Neurology
Professor of Neuroscience, Biomedical Engineering, Psychological & Brain Sciences, and Radiology
Washington University

 Mar 14, 2019 @ 4:00 p.m.

 Medical Center | 1-9576 Ryan Case Method Auditorium

Host: Univ. Rochester School of Medicine and Dentistry, the Del Monte Institute for Neuroscience, and Dept. of Neuroscience

NSC 503, NSC Student Seminar

Karl Foley & Kate Andersh - Ph.D. Candidates

 Mar 04, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Mobilizing Synaptic Plasticity to Promote Recovery from Amblyopia

Mark Bear, PhD - Investigator of the Howard Hughes Medical Institute
Picower Professor of Neuroscience in The Picower Institute for Learning and Memory
Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology

 Feb 25, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC Thesis Proposal - The role of PI3Kg signaling in microglial dynamics and experience dependent synaptic plasticity

Brendan Whitelaw - Ph.D. Candidate
Advisor: Ania Majewska

 Feb 19, 2019 @ 10:00 a.m.

 Medical Center | K-207 (2-6408)

NSC 503, NSC Student Seminar

Anjali Sinha & Keshov Sharma - Ph.D. Candidates

 Feb 18, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Brendan Whitelaw & Uday Chockanathan - Ph.D. Candidates

 Feb 11, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Ally McHale & Neal Shah - Ph.D. Candidates

 Feb 04, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

NSC 503, NSC Student Seminar

Yunpeng Pang & Emily Warner - Ph.D. Candidates

 Jan 28, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)

Effects of challenging prenatal environments on human fetal brain network development

Moriah Thomason, Ph.D. - Associate Professor
Departments of Child and Adolescent Psychiatry and Population Health
New York University School of Medicine

 Jan 23, 2019 @ 3:00 p.m.

 Medical Center | Adolph Lower Aud (1-7619)

Host: Del Monte Institute for Neuroscience and Dept. of Neuroscience

NSC 503, NSC Student Seminar

Kamy Wakim & Kathleen Gates - Ph.D. Candidates

 Jan 14, 2019 @ 4:00 p.m.

 Medical Center | K-307 (3-6408)