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URMC / Emergency Medicine / Research / Global Health

Global Health

Background

Dr. Adler, the Director of Emergency Medicine Research, has longstanding involvement in Global Health, particularly in sub-Saharan Africa. He has conducted projects in Central African refugee camps under the auspices of the University of California at Berkeley's Human Rights Fellowship Program and in coordination with the Tanzanian Red Cross Society. His current research efforts focus on Human Papillomaviruses and cervical cancer risk among HIV-infected South African women.

Dr. Adler is also the Director of the International Emergency Medicine Fellowship in the Department of Emergency Medicine and supervises the Global Health Track for the Medicine-Pediatrics Residency at the University of Rochester.

Ongoing Projects

Cervical Cancer Risk and Screening Among HIV-Infected South African Women

Cervical cancer is the number one cancer cause of years of life lost in the developing world, in part due to its disproportionate impact on HIV-infected women as well as suboptimal screening. The purpose of this study is to (a) investigate the difference in risk for high-grade squamous intraepithelial lesions between HIV-infected and HIV-uninfected young women in Cape Town, South Africa and (b) to investigate a novel application of high-risk Human papillomavirus DNA testing accompanying cytology testing to screen HIV-infected young women for cervical cancer. This novel screening approach has the potential to change the standard of care for HIV-infected young women in the U.S. as well as the developing world. Our existing South African cohort serves as the foundation of this effort to develop the optimal evidence-based cervical cancer screening approach for HIV-infected young women.

Targeted Approach in HIV Prevention: Analysis of Behavior Patterns in Young Women in Masiphumelele and Gugulethu, South Africa

 

Post-Vaccination HPV Genotype Distribution Among HIV-infected and HIV-uninfected Young Women in South Africa

Learn more about HPV Genotype Distribution

Effect of HAART Therapy on Cervical Dysplasia in South Africa. Prospective Cohort Study of Impact of HAART on Regression and Progression of Cervical Dysplasia in HIV-infected Women.

This collaborative project is utilizing a large database of HIV-infected women in Soweto, South Africa in order to compare the rates of regression and progression of HPV-associated cervical lesions among women receiving HAART and women not receiving HAART.

Comparison of HPV Infection and Cervical Disease Between HIV-infected and HIV-uninfected Adolescent Females in Cape Town, South Africa

Learn more about HPV Infection and Cervical Disease 

Recent Publications

Adler D, Wallace M, Bennie T, Abar B, Sadeghi R, Meiring M, Williamson A, Bekker L. High Risk HPV Persistence Among HIV-infected Young Women in South Africa. International Journal of Infectious Diseases. 2015;81(1):3-6.

Griffith D, Adler D, Wallace M, Bennie T, Abar B, Bekker L. Knowledge of HPV among HIV-infected and HIV-uninfected Female Adolescents in South Africa. The Journal of Women’s Health, Issues & Care. 2015;4(5):1000203. PMICID: PMC4765383

O’Donnell S, Adler DH, Inboriboon PC, Alvarado FH, Acosta R, Monzon DG. Perspectives of South American Physicians Hosting Foreign Rotators in Emergency Medicine. International Journal of Emergency Medicine. 2014;7:24.

Kim S, Adler D. Ultrasound Assisted Lumber Puncture in Pediatric Emergency Medicine. Journal of Emergency Medicine.2014;47(1):59-64. 

Puran A, Adler D, Wallace M, Bennie T, Phuti A, Abar B, Bekker L. Incidental Findings of Bacterial Vaginosis and Other Infections in Papanicolaou Smears of HIV-infected and HIV-uninfected Adolescent Females in South Africa. International Journal of STD & AIDS. 2014. 

Adler D, Wallace M, Bennie T, Mrubata M, Abar B, Meiring T, Williamson A and Bekker L. Cervical Dysplasia and High-Risk Human Papillomavirus Infections Among  HIV-infected and HIV-uninfected Adolescent Females in South Africa. 2014. Article ID 498048. dx.doi.org/10.1155/2014/498048

Adler DH, Laher F, Lazarus E, Grzesik K, Gray GE, Allan B, Williamson AL. A Viable and Simple Self-Sampling Method for Human Papillomavirus Detection among South African Adolescents.Journal of Immunological Techniquies in Infectious Diseases. 2013 Sep 18;2(3).PMID: 24324979.

Adler DH, Almudevar A, Gray GE, Allan B, Williamson AL. High level of agreement between clinician-collected and self-collected samples for HPV detection among South African adolescents. Journal of Pediatric & Adolescence Gynecology. 2012 Aug;25(4):280-1. PMID: 22840940

Adler DH, Kakinami L, Modisenyane T, Tshabangu N, Mohapi L, De Bruyn G, Martinson NA, Omar T. Increased regression and decreased incidence of human papillomavirus-related cervical lesions among HIV-infected women on HAART. AIDS 26(13): 1645-1652.

Adler DH, Almudevar A, Gray GE, Allan B, Williamson AL. High level of agreement between clinician-collected and self-collected samples for HPV detection among South African adolescents. Journal of Pediatric & Adolescence Gynecology. 25(4): 280-281.

Adler DH. Inclusion of South African Adolescents in HIV Vaccine Trials. Journal of AIDS and HIV Research. 2012;4:30-35.

Archive Publications

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Funding

Source Type Description
K23 Post-Vaccination HPV Genotype Distribution Among HIV-infected and HIV-uninfected YOung Women in South Africa.