People who have AIDS are much more likely to get certain types of cancer than people
without the disease. When people who have HIV develop certain cancers, healthcare
providers consider their HIV infection to have progressed to AIDS. These types of
cancer include Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer.
People with HIV or AIDS are also often more likely to develop cancer of the skin,
anus, lung, and liver, as well as develop Hodgkin lymphoma.
Facts about AIDS-related malignancies
Kaposi sarcoma is a rare cancer among people who don’t have HIV. In fact, HIV infection
increases the risk of Kaposi sarcoma by several thousand times compared with those
who do not have HIV. People with HIV infection are at least 20 to 70 times more likely
to develop non-Hodgkin lymphoma, 10 times more likely to develop Hodgkin lymphoma,
and 25 times more likely to develop anal cancer. They are also 5 times more likely
to develop cervical and liver cancer, and at least 3 times more likely to develop
lung cancer than people who do not have HIV/AIDS.
Although AIDS is associated with an increased risk for several types of cancer, certain
AIDS-related cancers have become less common. This may be because of the wider use
of antiretroviral, or anti-HIV medicines, which combat the virus that causes AIDS.
When a person becomes infected with HIV, the immune system doesn't work as well. As
a result, cancers may develop more quickly and become harder to treat, since the immune
system usually helps fight cancerous cells before they turn into tumors. People who
are taking anti-HIV medicines—medicines that help boost the immune system—may be better
able to benefit from anticancer treatments.
Different types of AIDS-related cancers cause different symptoms. These may include:
Kaposi sarcoma. A visible symptom of this cancer is purple or brown spots (lesions) on the skin or
inside the mouth. The disease can affect internal organs and tissues. These include
the lungs, digestive tract, and lymph nodes. It can also cause fever, diarrhea, and
Non-Hodgkin lymphoma. Symptoms are fever; unexplained weight loss; sweating at night; swollen lymph nodes
in the underarms, groin, and neck; and a sense of fullness in the chest. Other symptoms
can include memory loss, seizures, and fatigue.
Cervical cancer. This may not cause symptoms, especially early in its growth. Eventually, however,
cervical cancer may cause abnormal vaginal bleeding, discomfort during sex, and an
unusual vaginal discharge.
Anal cancer. Symptoms may include pain in the anal area, bleeding, itching, a change in bowel
habits, or a lump in the area.
Lung cancer. Symptoms can include severe coughing, which may bring up blood; chest pain; trouble
breathing; fatigue; and weight loss.
To diagnose Kaposi sarcoma, a healthcare provider may do a physical exam and remove
a sample of a lesion to inspect under a microscope. You may also need a chest X-ray
to see if the disease has affected your lungs. A healthcare provider may also need
to inspect your lungs directly using a small scope to take pictures and tissue samples.
Kaposi sarcoma can also affect the digestive system, so an endoscopy and/or colonoscopy
may also be necessary to examine the upper and lower digestive tract.
Likewise, a number of tests may be needed to diagnose AIDS-related lymphoma, including
blood tests and biopsies. Other tests might include CT or MRI scans. These create
images of the inside of your body. The healthcare provider may also perform a physical
exam to see how well your brain and nervous system are working. The healthcare provider
may do a lumbar puncture to check the fluid in your spinal cord for cancer, as well.
A healthcare provider may find early cervical cancer, or cells that could become cancerous,
during a Pap test. A healthcare provider may do a physical exam and a digital rectal
exam to check for anal cancer. Other ways to diagnose this disease include inspecting
the area with a special scope or removing cells to examine under the microscope.
To diagnose lung cancer, a healthcare provider may obtain images of your lungs with
an X-ray, CT, or MRI scan. Blood tests may also be helpful. The healthcare provider
may analyze mucus, fluid, or tissue from your lung. Other tests might be needed to
look for cancer spread.
Healthcare providers may treat Kaposi sarcoma with anti-HIV medicines. Other treatments
might include surgery (or other local treatments), chemotherapy, immunotherapy, and
Treatment for AIDS-related lymphoma may include the use of anti-HIV medicines, chemotherapy,
and radiation. Treatment for cervical cancer often begins with a small procedure to
remove the cancer. In some cases, chemotherapy, radiation, and/or surgery to remove
the uterus and other tissues may be necessary as well. Surgery, chemotherapy, and
radiation are also used to treat anal and lung cancers.
Preventing infection from HIV will prevent AIDS-related malignancies. Important steps
to lower your risk include:
Not sharing needles or syringes with other people
Avoiding unprotected sex
Limiting how many sexual partners you have
Not coming into contact with other people's blood
Getting tested for HIV and other sexually transmitted diseases on a regular basis
Other steps can help prevent some other types of AIDS-related cancers:
Not smoking and avoiding secondhand smoke to lower your risk for lung cancer and some
Limiting your sex partners, using condoms, and not smoking to lower the risk for cervical
cancer. Having regular checkups can allow your healthcare provider to find abnormal
cells before they develop into cancer. Being vaccinated against the HPV virus might
also reduce the risk in people who are not already infected.
Managing this condition
If you have an AIDS-related cancer, your healthcare provider may recommend steps you
can take on your own to reduce your symptoms. Be sure to discuss the different therapies
that are available for AIDS-related cancer with your healthcare provider since many
treatment choices do exist.