Brucella Antibody (CSF)
Does this test have other names?
CSF agglutination test
What is this test?
This test looks at fluid from your spinal cord to find out if you have an illness
Brucellosis is an infectious disease usually caused by handling animals or milk products
infected with the brucella bacteria. If you have brucellosis, your body will make
certain antibodies when it tries to fight these germs. Brucella antibodies can usually
be found in your blood, liver, spleen, lymph nodes, or bone marrow.
In 2% to 7% of brucella infections, the bacteria infect the brain, spine, and other
parts of the nervous system. This test looks at your cerebrospinal fluid (CSF) to
find out if you have a brucella infection that has spread to your nervous system.
The disease is rare in the U.S. Fewer than 200 cases are reported here each year.
It's more commonly found in Latin America, the Middle East, and the Mediterranean.
This is why it's often called Mediterranean or Malta fever. It's also called undulant
fever, Bang's disease, and Gibraltar fever.
If brucellosis isn't treated after a few months, you may start to feel unusually weak.
You may also get a fever and chills, headaches, backache, muscle and joint pain, and
sweats. You may lose your appetite and appear anorexic. If untreated, the bacteria
can sometimes damage the heart, joints, or central nervous system. Or they may cause infections
that keep coming back. If you are pregnant and have brucellosis, it may cause a miscarriage
or infect your unborn child.
Why do I need this test?
You may have this test if your healthcare provider thinks you are infected with brucella
bacteria and that the infection has spread to your brain. He or she may think this
You work in a slaughterhouse and have symptoms of the illness.
You work in a slaughterhouse, dairy, or farm and may have been in contact with the
bacteria through a cut or open wound.
You hunt deer, wild pigs, or other animals and have symptoms of the illness. You may
have been in contact while cleaning a carcass without gloves.
You have traveled to Spain, Greece, Mexico, or another country where brucellosis is
common and have eaten unpasteurized milk, cheese, or ice cream.
You are a veterinarian and may have been come in contact with the bacteria. Or by
accident you injected yourself with the vaccine used to protect cattle against brucella.
People almost never get brucellosis from contact with dogs unless their immune system
is very weak from HIV/AIDS or another condition.
You work in a laboratory where you handle brucella bacteria.
What other tests might I have along with this test?
Your healthcare provider may also have ordered other tests before the spinal tap to
find out whether you've come in contact with brucella bacteria.
Your provider may also order an MRI scan if you have back pain to see if you have
damage to your spinal cord
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
Normal results are negative. This means no brucella antibodies were found in your
CSF. A negative result doesn't completely rule out an infection, though.
A positive result means that brucella antibodies were found and that you have an infection.
How is the test done?
This test requires a sample of cerebrospinal fluid. This is taken through a lumbar
puncture in your lower back. During this procedure, you either sit up and lean forward
or lie down on your side. A healthcare provider inserts a needle into your spine and
draws out a sample of fluid.
Does this test pose any risks?
It's rare to get complications after having this test. But possible risks include:
Nerve pain or numbness
Talk with your provider about the risks before the test. Be sure to tell your provider
if you've had a seizure, increased pressure in your eyes, or other health problems.
You may need to have other tests before having a lumbar puncture.
What might affect my test results?
Having the test too soon after infection can affect your results.
How do I get ready for this test?
You don't need to prepare for this test.