Does this test have other names?
What is this test?
This test is done to find out if you have abnormal proteins in your blood.
Blood proteins include normal immunoglobulins, or antibodies, like IgG and IgM. But
they can also include antibodies linked to autoimmune diseases. These abnormal blood
proteins are dissolved in your blood at body temperature. But when you are in a cold
environment, they thicken and clump together. This restricts the blood flow to your
joints, muscles and organs. This can eventually lead to damage and inflammation of
your blood vessels and tissues.
These abnormal proteins are called cryoglobulins. High levels of cryoglobulins may
be a sign that your body is making abnormal proteins. This condition is seen with
a number of disorders and conditions, such as Raynaud's syndrome, lupus, rheumatoid
arthritis, Sjogren's syndrome, leukemia, and lymphoma.
Why do I need this test?
You may need this test if your healthcare provider suspects that you have a problem
with your blood proteins. Symptoms tend to occur in cold weather and include:
Numbness or tingling
Coldness in the fingers
In more severe cases, it can also cause joint pain or tissue damage.
What other tests might I have along with this test?
Your healthcare provider may also order a joint fluid analysis if he or she suspects
that you have a systemic inflammatory disease, such as lupus or rheumatoid arthritis.
Your healthcare provider may also order tests to measure blood levels of other antibodies,
including antinuclear antibodies, antibodies to DNA, and antibodies to phospholipids.
What do my test results mean?
Many things may affect your lab test results. These include the method each lab uses
to do the test. Even if your test results are different from the normal value, you
may not have a problem. To learn what the results mean for you, talk with your healthcare
A normal test is negative for cryoglobulins. This means the antibodies in your blood
stay dissolved even when the blood is chilled.
If you test positive for cryoglobulins, it means these proteins became visibly sludge-like
when your blood sample was refrigerated. If your cryoglobulin test is positive, your
healthcare provider will do more tests to find out the cause.
How is this test done?
The test requires a blood sample, which is drawn through a needle from a vein in your
Does this test pose any risks?
Taking a blood sample with a needle carries risks that include bleeding, infection,
bruising, or feeling dizzy. When the needle pricks your arm, you may feel a slight
stinging sensation or pain. Afterward, the site may be slightly sore.
What might affect my test results?
Other factors aren't likely to affect your results.
How do I get ready for this test?
You may need to not eat or drink anything but water for eight hours before the test.