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Prealbumin (Blood)

Does this test have other names?

PA, transthyretin test

What is this test?

The prealbumin screen is a blood test to see if you are getting enough nutrition in your diet. This may be because you have a chronic condition. Or it may be because you have an infection or inflammation, or you suffered a trauma. Prealbumin is a protein that is made mainly by your liver. Your body uses prealbumin to make other proteins. Prealbumin also carries thyroid hormones in the blood.

Why do I need this test?

You might have this test if your healthcare provider thinks you may have an infection, inflammation, or poor nutrition. You may also have this test if you have had trauma. Your healthcare provider may also order this test while you are in the hospital to see if you need more nutritional or medical care as part of your treatment.

What other tests might I have along with this test?

To watch your nutritional needs, your healthcare provider might order a C-reactive protein screen. This looks for another protein in your blood. Your provider may also order tests for hemoglobin, albumin, iron, transferrin, folate, and vitamin B-12, and other electrolytes, vitamins, and minerals.

What do my test results mean?

Many things may affect your lab test results. These include the method each lab uses to do the test. Even if your test results are different from the normal value, you may not have a problem. To learn what the results mean for you, talk with your healthcare provider.

Low prealbumin scores mean that you are likely to need a nutritional assessment. Low prealbumin scores may also be a sign of liver disease, inflammation, or tissue death (tissue necrosis). High prealbumin scores may be a sign of long-term (chronic) kidney disease, steroid use, or alcoholism.

Normal results for a prealbumin blood test are:

  • Adults: 15 to 36 milligrams per deciliter (mg/dL) or 150 to 360 milligrams per liter (mg/L)

  • Children: 6 to 21 mg/dL for an infant under 5 days old, 14 to 30 mg/dL for children ages 1 to 5, 15 to 33 mg/dL for children ages 6 to 9, 22 to 36 mg/dL for those ages 10 to 13, 22 to 45 mg/dL for those ages 14 to 19

How is this test done?

The test requires a blood sample, which is drawn through a needle from a vein in your arm.

Does this test pose any risks?

Taking a blood sample with a needle carries a small risk of bleeding, infection, or bruising. You may also feel dizzy. When the needle pricks your arm, you may feel a slight sting. Afterward, the site might be sore.

What might affect my test results?

Infection, inflammation, or recent trauma may affect your test results. This could make them more difficult to figure out. Experts suggest that people in the hospital who are tested for prealbumin be tested twice. This should be done 3 to 5 days apart, for more accurate results.

How do I get ready for this test?

No preparation is necessary.


Medical Reviewers:

  • Freeborn, Donna, PhD, CNM, FNP
  • Hanrahan, John, MD
  • Pierce-Smith, Daphne, RN, MSN, CCRC