Urethral Cancer Overview
What is urethral cancer?
Cancer is made of changed cells that grow out of control. The changed (abnormal) cells
often grow to form a lump or mass called a tumor. Cancer cells can also grow into
(invade) nearby areas. And they can spread to other parts of the body. This is called
Urethral cancer is a very rare type of cancer that starts in the urethra. This is
the tube that carries urine out of your body. In women, the urethra is about 1.5 inches
long. It reaches from the bladder to an opening above the vagina. In men, the urethra
is about 8 inches long. It passes through the prostate and the penis to an opening
on the tip of the penis (glans).
Who is at risk for urethral cancer?
A risk factor is anything that may increase your chance of having a disease. The exact
cause of someone’s cancer may not be known. But risk factors can make it more likely
for a person to have cancer. Some risk factors may not be in your control. But others
may be things you can change.
Because urethral cancer is so rare, it’s been hard for healthcare providers to find
risk factors for the disease. These are possible risk factors for this cancer:
Long-lasting (chronic) irritation or inflammation of the urinary tract because of
repeated urinary tract infections (UTIs) or sexually transmitted infections (STIs)
Certain diseases, such as urethral diverticulum, polyps, or urethral caruncle in women
and urethral strictures in men
History of bladder cancer
HPV (human papillomavirus) infection or history of other STIs
Being African American
Talk with your healthcare provider about your risk factors for urethral cancer and
what you can do about them.
Can urethral cancer be prevented?
There’s no sure way to prevent urethral cancer. But you can protect yourself from
STIs to help reduce your risk for cancer and other health problems.
Are there screening tests for urethral cancer?
There are no regular screening tests for urethral cancer. Screening tests are done
to check for disease in people who don’t have symptoms.
What are the symptoms of urethral cancer?
Urethral cancer can be a silent disease. It may not cause any symptoms when the cancer
is small. It may cause these symptoms as the tumor grows:
Blood in your urine
Discharge or bleeding from the urethra
Frequent urination or a frequent urge to urinate without passing much urine
Trouble passing urine
Pain, low flow, or dribbling while urinating
Inability to control urine (urinary incontinence)
Enlarged lymph nodes in the groin
Lump or growth in the penis or in the area between your genitals and anus (perineum)
Many of these may be caused by other health problems. But it’s important to see a
healthcare provider if you have these symptoms. Only a healthcare provider can tell
if you have cancer.
How is urethral cancer diagnosed?
People are often treated for other problems first. This might be a urinary tract infection
or, in men, BPH (benign prostate hyperplasia). When usual treatments don’t work, your
provider may suspect urethral cancer. You may be sent to a urologist. This is a healthcare
provider with special training to treat problems in the urinary system.
Your healthcare provider will ask you about your health history, your symptoms, risk
factors, and family history of disease. They will do a physical exam. Men may have
a digital rectal exam. Women will have a pelvic exam. These tests are done to look
and feel for tumors around the urethra.
You may also have 1 or more of these tests:
A biopsy is the only way to confirm cancer. Small pieces of tissue are taken out and
checked for cancer cells.
After a diagnosis of urethral cancer, you’ll likely need other tests. These help your
healthcare providers learn more about the cancer. They can help determine the stage
of the cancer. The stage is how much and how far the cancer has spread (metastasized)
in your body. It is one of the most important things to know when deciding how to
treat the cancer.
Once your cancer is staged, your healthcare provider will talk with you about what
the stage means for your treatment. Be sure to ask your healthcare provider to explain
the stage of your cancer to you in a way you can understand.
How is urethral cancer treated?
Your treatment choices depend on the type of urethral cancer you have, where it is
in the urethra, your gender, test results, and the stage of the cancer. The goal of
treatment may be to cure you, control the cancer, or to help ease problems caused
by the cancer. Talk with your healthcare team about your treatment choices, the goals
of treatment, and the possible risks and side effects.
Types of treatment for cancer are either local or systemic. Local treatments remove,
destroy, or control cancer cells in 1 area. Surgery and radiation are local treatments.
Systemic treatment is used to destroy or control cancer cells that may have traveled
around your body. When taken by pill or injection, chemotherapy is a systemic treatment.
You may have just 1 treatment or a combination of treatments.
Urethral cancer may be treated with:
Another option in some cases is active surveillance. This means the cancer is not
treated right away. Instead, your healthcare provider closely watches it with regularly
scheduled exams and tests. If the tests show that it’s started to grow or the cancer
starts to cause problems, then you can start treatment. This option lets you delay
or even not have treatments that can cause major side effects and other problems.
Talk with your healthcare providers about your treatment options. Make a list of questions.
Think about the benefits and possible side effects of each option. Talk about your
concerns with your healthcare provider before making a decision.
What are treatment side effects?
Cancer treatment such as chemotherapy and radiation can damage normal cells. This
can cause side effects such as hair loss, mouth sores, and vomiting.
Talk with your healthcare provider about side effects you might have and ways to deal
with them. There may be things you can do and medicines you can take to help prevent
or control side effects.
Coping with urethral cancer
Many people feel worried, depressed, and stressed when dealing with cancer. Getting
treatment for cancer can be hard on your mind and body. Keep talking with your healthcare
team about any problems or concerns you have. Work together to ease the effect of
cancer and its symptoms on your daily life.
Here are tips:
Talk with your family or friends.
Ask your healthcare team or social worker for help.
Speak with a counselor.
Talk with a spiritual advisor, such as a minister or rabbi.
Ask your healthcare team about medicines for depression or anxiety.
Keep socially active.
Join a cancer support group.
Cancer treatment is also hard on the body. To help yourself stay healthier, try to:
Eat a healthy diet, with a focus on high-protein foods.
Drink plenty of water, fruit juices, and other liquids.
Keep physically active.
Rest as much as needed.
Talk with your healthcare team about ways to manage treatment side effects.
Take your medicines as directed by your team.
When should I call my healthcare provider?
Your healthcare provider will talk with you about when to call. You may be told to
call if you have any of the below:
New symptoms or symptoms that get worse
Signs of an infection, such as a fever
Side effects of treatment that affect your daily function or don’t get better with
Ask your healthcare provider what signs to watch for and when to call. Know how to
get help after office hours and on weekends and holidays.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.