What is ankylosing spondylitis?
Ankylosing spondylitis (AS) is a type of arthritis that affects the spine. Ankylosing
means stiff or rigid. Spondyl means spine. Itis refers to inflammation. The disease
causes inflammation of the spine and large joints, resulting in stiffness and pain.
The disease may damage the joint between the spine and the hipbone. This is called
the sacroiliac joint. It may also cause bony bridges to form between vertebrae in
the spine, fusing those bones. Bones in the chest may also fuse.
What causes ankylosing spondylitis?
Doctors don't know what causes AS, but researchers think that genes play a role. A
gene called HLA-B27 happens in most Caucasian Americans who have AS. But in only half
of African Americans who have it. But some people with the HLA-B27 gene don't have
AS. Less than 1 in 20 people with the HLA-B27 gene have AS.
Who is at risk for ankylosing spondylitis?
AS is more common among people ages 17 to 35. It can happen in children and older
adults as well. The disease affects more young men than women. It tends to run in
What are the symptoms of ankylosing spondylitis?
Symptoms of AS tend to come and go over time. Symptoms can occur a bit differently
in each person. The symptoms may include:
Back pain, usually most severe at night during rest
Early morning stiffness
Stooped posture in response to back pain (bending forward tends to relieve the pain)
Straight and stiff spine
Inability to take a deep breath, if the joints between the ribs and spine are affected
Mild eye inflammation
Organ damage, such as to the heart, lungs, and eyes
Digestive illness (such as Crohn's or ulcerative colitis)
The symptoms of ankylosing spondylitis can look like other health conditions. Make
sure to see your healthcare provider for a diagnosis.
How is ankylosing spondylitis diagnosed?
Diagnosis starts with a health history and physical exam. You may also need tests,
X-ray. This test uses a small amount of radiation to create images of internal tissues,
bones, and organs onto film.
Erythrocyte sedimentation rate (ESR or sed rate). This test looks at how quickly red blood cells fall to the bottom of a test tube.
When swelling and inflammation are present, the blood's proteins clump together and
become heavier than normal. They fall and settle faster at the bottom of the test
tube. The faster the blood cells fall, the more severe the inflammation. Up to 7 in
10 people with AS have a high ESR.
Genetic testing. Genetic testing is done to find if a person carries a copy of an altered gene for
a disease. The gene HLA-B27 is found in more than 19 in 20 people with AS.
How is ankylosing spondylitis treated?
Treatment will depend on your symptoms, your age, and your general health. It will
also depend on how severe the condition is. The goal of treatment is to ease pain
and stiffness, prevent deformities, and maintain as normal a lifestyle as possible.
Treatment may include:
Nonsteroidal anti-inflammatory medicines (NSAIDs), to ease pain and inflammation
Tumor-necrosis-factor blockers (biologic medicines), to ease inflammation and swelling
Interleukin-17A (IL-17A) inhibitors, to ease inflammation and swelling
Disease-modifying anti-rheumatic medicines (DMARDs), such as sulfasalazine, to ease
inflammation and control AS
Short-term use of corticosteroids, to ease inflammation
Short-term use of muscle relaxants and pain relievers, to ease severe pain and muscle
Surgery to replace a joint, place rods in the spine, or remove parts of the thickened
and hardened bone
Maintaining of proper posture
Regular exercise, including exercises that strengthen back muscles
Talk with your healthcare providers about the risks, benefits, and possible side effects
of all medicines.
What are the possible complications of ankylosing spondylitis?
Over time, a forward curve of the spine can develop in people with AS. People with
AS are at great risk of thinning of the bones (osteoporosis). This can result in spinal
fractures. AS can also lead to psoriasis, and inflammation of the eye, aortic valve,
and intestinal tract.
Living with ankylosing spondylitis
There is no cure for AS, so it is important to work on a treatment plan with your
healthcare provider. Work on lifestyle changes that can improve your quality of life.
Stay active and keep up with exercise to reduce pain. A physical therapist can help
you design an exercise plan and help you keep a good posture.
When should I call my healthcare provider?
If your symptoms get worse or you have new symptoms, let your healthcare provider
Key points about ankylosing spondylitis
Ankylosing spondylitis is a type of arthritis that affects the spine.
A gene may be part of the cause of AS.
Symptoms of AS include back pain, early morning stiffness, and a stooped posture.
AS can cause other symptoms such as appetite loss, weight loss, fatigue, fever, anemia,
eye inflammation, and digestive illness.
The goal of treatment for AS is to ease pain and stiffness, prevent deformities, and
maintain as normal a lifestyle as possible.
Staying active is important in the management of AS.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.