What are pituitary tumors?
A pituitary tumor is an abnormal growth in the pituitary gland. The pituitary is a
small gland in the brain. It is located behind the back of the nose. It makes hormones
that affect many other glands and many functions in your body. Most pituitary tumors
are not cancer (benign). They don’t spread to other parts of your body. But they can
cause the pituitary to make too few or too many hormones, causing problems in the
Pituitary tumors that make too many hormones will often cause other glands to make
more hormones. That will cause symptoms linked to each of the specific hormones. Many
pituitary tumors will also press against the nearby optic nerves. This can cause vision
Most pituitary tumors don’t cause symptoms. So they are not diagnosed. Or they are
found only during routine brain imaging or blood tests. About 1 in 4 people may have small
pituitary tumors without knowing it.
Below are the main types of benign pituitary tumors.
Nonfunctional adenomas (null cell adenomas)
These tumors are the most common type. They don’t make extra hormones. You may not
have any symptoms until the tumor is a certain size. When the tumor is big enough,
it may cause headaches and vision problems. Large pituitary tumors can put pressure
on normal pituitary cells. This leads to symptoms caused by decreased hormone production.
Prolactin-producing tumors (prolactinomas)
These benign tumors are also common. They make too much prolactin. If you are a woman,
high prolactin levels can make your menstrual period irregular, or even stop your
period. These tumors can also cause you to make breastmilk, even if you are not pregnant
or nursing. If you are a man, you may have erectile dysfunction or a lack of interest
in sex. You may also have enlarged breasts, a low sperm count, or less body hair.
In time, you may have headaches and vision problems.
These tumors make too much ACTH (adrenocorticotropic hormone). This hormone stimulates
the adrenal gland to make steroids that affect metabolism. These are called glucocorticoids.
They reduce redness and swelling (inflammation) all over the body. They also slow
down your immune system. Too much ACTH can cause Cushing disease. This disease causes
fat buildup in your face, neck, back, belly (abdomen), and chest. Also your arms and
legs tend to become thin. You may also have purple stretch marks and high blood pressure.
These tumors can also weaken your bones.
Growth hormone-producing tumors
These tumors make too much growth hormone. In children, too much growth hormone stimulates
the growth of almost all the bones in the body. When that occurs, the result is called
gigantism. Gigantism can include increased height (over 7 feet), very quick growth,
joint pain, and heavy sweating. In adults, too much growth hormone causes a condition
called acromegaly. It may include:
Extra growth in the skull, hands, and feet
A change in the facial appearance because of extra growth in the facial bones
A wide spacing of teeth because of the growth of facial bones
Snoring or sleep apnea
Diabetes or impaired glucose tolerance
High blood pressure from enlargement of the heart muscle and fluid retention
Other hormone-producing tumors
Thyroid-stimulating hormone-producing tumors
These tumors are fairly rare. They make too much thyroid-stimulating hormone. Too
much of this hormone leads to increased activity of the thyroid and symptoms of hyperthyroidism.
These include weight loss, a fast heartbeat, and sweating. This is a very rare pituitary
condition. Healthcare providers often treat people for an overactive thyroid and only
diagnose a thyroid-stimulating tumor after the treatment was unsuccessful, or the
person has headaches or other hormonal problems.
These tumors are also rare. They release excess hormones which stimulate the ovaries
What causes pituitary tumors?
Experts don't know what causes these tumors. But a condition called multiple endocrine
neoplasia type I (MEN 1) may raise your risk. This condition is passed down through
What are the symptoms of pituitary tumors?
Symptoms depend on the type of tumor and the area of the pituitary gland that is affected.
These tumors can lead to symptoms caused by too much or too little of the pituitary
hormones. Each person’s symptoms may vary.
The symptoms may also look like other health problems. Always see your healthcare
provider for a diagnosis.
How are pituitary tumors diagnosed?
Your healthcare provider will ask about your health history and do a physical exam.
You may also need one of these tests:
Blood and urine tests. These tests will check hormone levels in your blood and urine.
CT scan. This test uses X-rays and a computer to make detailed images of your body.
MRI. This test uses large magnets, radio waves, and a computer to make detailed images
of organs and structures in your body.
Biopsy. During this test, the provider removes a tissue sample with a needle or during surgery.
It is then checked under a microscope. A biopsy can tell if cancer or other abnormal
cells are present.
How are pituitary tumors treated?
Treatment will depend on your symptoms, age, and general health. It will also depend
on how severe the condition is.
Treatment may include:
Surgery to remove the tumor. Surgery is often a better option for smaller tumors.
External radiation (external beam therapy). This treatment sends high levels of radiation right to the tumor cells. Special shields
may be used to protect the tissue around the treatment area. These treatments are
painless and often last a few minutes.
Radiosurgery (stereotactic radiosurgery) or gamma knife treatment. This is often one high dose of radiation sent right into the tumor tissue. It causes
less damage to nearby tissues. It is not actually surgery. But like surgery, it is
a one-session treatment that removes the tumor.
Medicine. Different types of medicine may be used to control how much growth hormone, prolactin,
or other hormone is made by the tumor.
When should I call my healthcare provider?
Call your healthcare provider if your symptoms return or you have new symptoms.
Key points about pituitary tumors
A pituitary tumor is an abnormal growth in the pituitary gland. Most pituitary tumors
are not cancer (benign).
The pituitary is a small gland in the brain. It makes hormones that affect many other
glands and many functions in your body.
Symptoms vary depending on the type of tumor and the area of the pituitary gland affected.
You may need blood and urine tests, a CT scan, MRI, or biopsy to diagnose the tumor.
Treatment may include surgery, radiation therapy, or medicine.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells
At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your provider if you have questions.