Interstitial Lung Disease
What are interstitial lung diseases?
Interstitial lung disease is the name for a group of more than 200 lung disorders.
Most of them are long lasting, or chronic. These diseases inflame or scar the lungs.
The inflammation and scarring make it hard to get enough oxygen. The scarring is called
Fibrosis leads to long-term (permanent) loss of your lung tissue’s ability to carry
oxygen. When the scar tissue forms, it destroys the air sacs. It also destroys the
lung tissue around the air sacs and the lung capillaries.
The symptoms and course of these diseases may vary from person to person. The common
link between the many forms of the disease is that they all often start with inflammation
in the interstitium. The interstitium is the supporting structure of the lungs. It's
almost like a scaffolding. This inflammation then causes inflammation in other parts
of the lung, leading to conditions such as:
Bronchiolitis. This is inflammation of the small airways (bronchioles).
Alveolitis. This is inflammation of the air sacs where oxygen and carbon dioxide exchange in
the blood takes place (alveoli).
Vasculitis. This is inflammation that affects the small blood vessels (capillaries).
What causes interstitial lung diseases?
Interstitial lung disease has been linked to certain diseases, such as sarcoidsosis
or rheumatoid arthritis. It can also be caused by factors in the environment. Often,
its cause is not known.
Major contributing factors are smoking and inhaling environmental or occupational
pollutants, such as inorganic or organic dusts.
Other factors include:
What are the symptoms of interstitial lung diseases?
Symptoms are a bit different for each person. The disease may run a slow or rapid
course. People with the disease may have symptoms that range from very mild to moderate
to very severe. The condition may stay the same for a long time. Or it may change
quickly. The course of the disease is unpredictable. If it progresses, the lung tissue
thickens and becomes stiff. Breathing becomes more difficult.
Here are the most common symptoms:
Shortness of breath, especially with activity
Dry, hacking cough that does not produce phlegm
Extreme tiredness and weakness
Unexplained weight loss
Mild pain in the chest
Labored breathing, which may be fast and shallow
Bleeding in the lungs
These symptoms may look like other lung conditions or health problems. Talk with your
healthcare provider for a diagnosis.
How are interstitial lungs diseases diagnosed?
A healthcare provider will ask about your health history and do a physical exam. You
may also need pulmonary function tests. These tests help to measure the lungs’ ability
to move air into and out of the lungs. The tests are often done with machines into
which you breathe. They may include the following:
A spirometer is a device used to check lung function. Spirometry is one of the simplest,
most common tests. It may be used to:
Determine how well the lungs receive, hold, and move air
Look for lung disease
See how well treatment is working
Determine the severity of a lung disease
Find out if the lung disease is restrictive. This is when the lungs get stiff and
can't hold as much air. Or if the lung disease is obstructive. This is when airflow
is disrupted in the airways.
Peak flow monitoring
This device is used to measure how fast you can blow air out of the lungs. Disease-related
changes can cause the large airways in the lungs to slowly narrow. This will slow
the speed of air leaving the lungs. This measurement is very important in evaluating
how well or how poorly the disease is being controlled.
This test takes pictures of internal tissues, bones, and organs.
Arterial blood gas may be done to check the amount of carbon dioxide and oxygen in
the blood. Other blood tests may be used to look for possible infections or other
diseases that may cause interstitial lung disease.
This test uses a combination of X-rays and a computer to make images of the body.
CT scans are more detailed than regular X-rays.
This test is a direct exam of the main airways of the lungs (bronchi). It uses a flexible
tube called a bronchoscope. Bronchoscopy helps to evaluate and diagnose lung problems,
check blockages, take out samples of tissue or fluid, and help remove a foreign body.
It may include a biopsy or bronchoalveolar lavage.
This test removes cells from the lower respiratory tract to help find inflammation
and rule out certain causes.
This test removes a small piece of tissue from the lung so it can be checked under
How are interstitial lung diseases treated?
Because there are so many causes, treatment will vary. Some interstitial lung diseases
don't have a cure. Treatment is aimed at preventing more lung scarring, managing symptoms,
and helping you stay active and healthy. Treatment can’t fix lung scarring that has
Treatments may include:
Medicine taken by mouth (oral), including corticosteroids to reduce inflammation and
cyclophosphamide to suppress the immune system. Some medicines protect the lung from
more damage and scarring. These are called antifibrotics and include nintedanib and
Oxygen therapy, from portable containers
If you smoke or use vaping devices, ask your healthcare provider for help to stop.
Also check with your healthcare provider about getting the flu and pneumococcal shots.
Getting a flu shot every year can help prevent both the flu and pneumonia. In addition,
pneumococcal bacteria can cause minor problems such as ear infections. But they can
also develop into life-threatening illnesses of the lungs (pneumonia), the covering
of the brain and spinal cord (meningitis), and the blood (bacteremia). Anyone can
get pneumococcal disease. But those at highest risk include children younger than
age 2, adults ages 65 and older, people with certain health problems, and smokers.
Talk with your healthcare provider about the pneumococcal vaccine. The CDC recommends
it for all children younger than 2 years old and all adults age 65 or older.
Key points about interstitial lung diseases
Interstitial lung disease is the name for a group of more than 200 lung disorders
that inflame or scar the lungs.
The cause is often not known. Major contributing factors are smoking and inhaling
environmental or occupational pollutants.
The most common symptoms are shortness of breath, especially with activity, and a
dry, hacking cough.
X-rays and other imaging studies are used to diagnose the condition. So are tests
that help measure the lungs’ ability to exchange oxygen and carbon dioxide.
The goal of treatment is to prevent more scarring, manage symptoms, and help you stay
active and healthy.
If you smoke, quitting is critical to help maintain as much lung health as possible.
Ask your healthcare provider about getting the flu and pneumococcal vaccines.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your healthcare
provider tells you.
At the visit, write down the name of a new diagnosis and any new medicines, treatments,
or tests. Also write down any new instructions your healthcare provider gives you.
Know why a new medicine or treatment is prescribed and how it will help you. Also
know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that
Know how you can contact your healthcare provider if you have questions.