Merkel Cell Carcinoma
What is Merkel cell carcinoma?
Merkel cell carcinoma is a rare type of skin cancer. Merkel cells are types of cells
in the upper layer of the skin. The cells are very close to nerve endings, and help
the skin sense light touch. Merkel cell carcinoma occurs when these cells grow out
of control. Merkel cell carcinoma can be dangerous because it tends to grow quickly.
It can be hard to treat if it spreads beyond the skin.
Merkel cells are a type of neuroendocrine cell. This means they have features of both
nerve cells and hormone-making cells. The cancer is also known as neuroendocrine carcinoma
of the skin.
What are the risk factors for Merkel cell carcinoma?
The known risk factors for Merkel cell carcinoma include:
Exposure to UV rays. Like many other types of skin cancer, the risk of Merkel cell carcinoma is higher
in people who have been exposed to a lot of UV (ultraviolet) rays from the sun or
from other sources like tanning beds. People who are treated for psoriasis with UV
rays may also have a higher risk.
Weakened immune system. People with weakened immune systems, such as people who have had an organ transplant,
are at increased risk for this cancer.
Light-colored skin. People with lighter skin are at higher risk.
Older age. People older than 50 are more likely to get this cancer.
Being male. Men are more likely to get Merkel cell carcinoma.
Researchers have found that Merkel cell carcinoma almost always shows infection with
a virus known as Merkel cell polyomavirus (MCV). It is not known how the virus may
contribute to the growth of this cancer. Most people are infected with this virus
at some point. But very few people develop this cancer.
What are the symptoms of Merkel cell carcinoma?
Merkel cell carcinoma tumors are most often found on sun-exposed areas of skin, such
as the face, neck, and arms. But they can start anywhere on the body. They usually appear
as firm, shiny skin lumps that don't hurt. The lumps may be red, pink, or blue. They
tend to grow very quickly.
How is Merkel cell carcinoma diagnosed?
The diagnosis of Merkel cell carcinoma is made with a biopsy. This is a sample of
tissue that’s taken and tested in a lab. Tumor samples are removed with a needle or
scalpel, or during surgery. They are checked with a microscope to see if cancer cells
are present. Diagnosis of Merkel cell carcinoma can be difficult. It can look like
many other types of cancer.
Early diagnosis and treatment of Merkel cell carcinoma is important to prevent the
cancer from spreading. Be aware of any lumps, growths, moles, or other abnormal areas
on your skin. Watch for new spots or areas that are changing. This can include skin
marks that grow larger, bleed, crust, or itch. Your healthcare provider may recommend
you do a skin self-exam once a month or more. See your healthcare provider if you
have any new or changing marks on the skin.
How is Merkel cell carcinoma treated?
Treatment is often done with more than 1 method. Treatment methods include:
Surgery to remove the tumor. This may include a border of healthy tissue. Since Merkel cell carcinoma grows fast
and often spreads (metastasizes), your provider may also remove nearby lymph nodes.
Radiation therapy. This therapy uses X-rays to kill cancer cells and shrink tumors. This may be used
after surgery. Or it may be the main treatment if surgery is not an option.
Chemotherapy. This treatment is done with medicines. It helps destroy cancer cells in cases where
the cancer has spread to other parts of the body.