What is glomerulosclerosis?
Glomerulosclerosis is scarring in the tiny blood vessels in the kidneys called the
glomeruli. These are the tiny units in the kidneys that filter urine from the blood.
What causes glomerulosclerosis?
Glomerulosclerosis may develop in children or adults. It can result from different
types of kidney problems, and from diabetes.
What are the symptoms of glomerulosclerosis?
Early stages of glomerulosclerosis may not cause any symptoms. The most important
sign of this condition is protein in the urine (proteinuria). This is often found
during a routine exam. The loss of large amounts of protein could cause swelling in
the ankles. It can also cause buildup of fluid in the abdomen, puffy eyes, or wide-spread
fluid buildup. Severe proteinuria could mean end stage renal disease (ESRD) will develop.
How is glomerulosclerosis diagnosed?
Scarring causes problems with the filtering process of the kidneys. This causes protein
to leak from the blood into the urine, where it can be detected.
Glomerulosclerosis is just one of many possible causes of protein in the urine. A
kidney biopsy may be needed to find the cause. About 7% to 15% of people with protein
in the urine have glomerulosclerosis.
What is the treatment for glomerulosclerosis?
Your healthcare provider will figure out the best treatment based on:
- How old you are
- Your overall health and medical history
- How sick you are
- How well you can handle specific medicines, procedures, or therapies
- How long the condition is expected to last
- Your opinion or preference
Scarred glomeruli cannot be repaired. Treatment aims to prevent further damage and
to avoid dialysis. The best treatment for glomerulosclerosis depends on what caused
the scarring. The cause is determined by a kidney biopsy. Treatment may include:
- Immune system medicines. Medicines used to block the body's immune system. This prevents the body from making
antibodies that may attack the glomerulus.
- Dialysis. A treatment to remove wastes and excess fluid from the blood after the kidneys have
- Kidney transplant. This procedure replaces your diseased kidney with a healthy one from a donor.
- Blood pressure lowering medicines
- Diet changes
Complications of glomerulosclerosis
Even with treatment, complications may develop. Your kidney function may decline to
the point of kidney failure. This can require treatment such as dialysis or even a
When should I call my healthcare provider?
If your symptoms get worse or you have new symptoms, let your healthcare provider
Key points about glomerulosclerosis
- Glomerulosclerosis is scarring of the filtering part of the kidneys (glomerulus).
This causes a loss of protein into the urine. These proteins help fluid stay within
the blood vessels. Without them, fluid leaks into the nearby tissue causing swelling.
- Fluids are not properly filtered from the body by the kidneys into the urine. This
causes fluid to build up in the body.
- Medicines to decrease the inflammation and swelling can be used.
- For severe scarring, dialysis or kidney transplant may be needed for long-term survival.
Tips to help you get the most from a visit to your healthcare provider:
- Know the reason for your visit and what you want to happen.
- Before your visit, write down questions you want answered.
- Bring someone with you to help you ask questions and remember what your provider tells
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments,
or tests. Also write down any new instructions your provider gives you.
- Know why a new medicine or treatment is prescribed, and how it will help you. Also
know what the side effects are.
- Ask if your condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if you do not take the medicine or have the test or procedure.
- If you have a follow-up appointment, write down the date, time, and purpose for that
- Know how you can contact your provider if you have questions.